SI9011710B - 13-alkil-23-imino in 13-halo-23-imino derivati makrolidnih spojin - Google Patents
13-alkil-23-imino in 13-halo-23-imino derivati makrolidnih spojin Download PDFInfo
- Publication number
- SI9011710B SI9011710B SI9011710A SI9011710A SI9011710B SI 9011710 B SI9011710 B SI 9011710B SI 9011710 A SI9011710 A SI 9011710A SI 9011710 A SI9011710 A SI 9011710A SI 9011710 B SI9011710 B SI 9011710B
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- SI
- Slovenia
- Prior art keywords
- alkyl
- hydrogen
- methyl
- isopropyl
- ethyl
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pest Control & Pesticides (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Agronomy & Crop Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Claims (8)
1 American Cynamid Company One Cynamid Plaza Wayne, NJ 07470-8426 USA 13-alkil-23-imino in 13-halo-23-imino derivati spojin LL-F28249 in kot endo in ektoparaziticidna insekticidna, akaricidna in nematocidna sredstva PATENTNI ZAHTEVKI 1. Spojina značilna po tem, da ima formulo: W
kj er: Ri je metil, etil ali izopropil; R7 je vodik in R8 je 0R2, ali kadar sta vzeta skupaj z ogljikovim atomom na katerega sta vezana R7 in Re predstavljata C=0; 2 R2 je vodik, Cx-C4 alkil ali O II C —R4 ; R4 je vodik, Ci-C4 alkil, C1-C4 haloalkil, Ci-C4 alkoksi, fenoksi, Cx-C4 alkoksimetil, fenoksimetil ali fenil, neobvezno substituiran z 1 nitro, 1-3 halogeni, 1-3 Ci~C4 alkilom, ali 1-3 Ci-C4 alkoksi; R3 je vodik metil ali etil; X je fluor, brom, klor ali jod; W je =N-Y; Y je OR5 or NHR6; R5 je Ci-C4 alkil ali Ci-C4 acil; R6 je Ci-C4 acil; in črtkana linija, ki tvori trikotnik s kisikom pri C26—č27 pomeni, da je prisotna ali dvojna vez ali epoksid.
2. Spojina po zahtevku 1, značilna po tem, da je Ri izopropil; R7 je vodik in R8 je 0R2; R2 je vodik, Ci-C4 alkil ali 0 II C R 4 r R4 je vodik, metil, klorometil, diklorometil, triklorometil ali metoksimetil R3 je metil; X je fluor W je Ν-Υ; Y je OR5; in R5 je Ci-C4 alkil. 3
3. Metoda zaščite pridelka, dreves, grmičevja, vskladiščenih zrn in okrasnih rastlin pred insekti, akaridi in nematodi, značilna po tem, da na omenjene pridelke, drevesa, grmičevje, vskladiščena zrna in okrasnihe rastline apliciramo insekticidno, akaricidno ali nematocidno učinkovito količino spojino s formulo po zahtevku 1.
4. Metoda po zahtevku 3, značilna po tem, da ima spojina formulo po spodnjem zahtevku 6 in da: Ri je izopropil; R7 je vodik; R8 je 0R2; R2 je vodik, C1-C4 alkil, ali 0 II C R 4 / R4 je vodik, metil, klorometil, diklorometil, triklorometil ali metoksimetil R3 je metil; X je fluor W je Ν-Υ; Y je 0R5; in R5 je Ci-C4 alkil.
5. Sestavek za nadzor endo- in ektoparazitov, insektov, akaridov in nematodov, značilen po tem, da obsega agronomsko sprejemljiv nosilec, ki vsebuje profilaktično, terapevtsko, farmacevtsko ali insekticidno učinkovito količino spojine s formulo po zahtevku 1. 4 r « • ·
6. Spojina, značilna po tem da ima strukturno formulo: X
kj er: Ri je C1-C4 alkil; R2 je vodik metil ali etil R3 je vodik, C1-C4 alkil, ali 0 tl c—r5 ; Rs je vodik, C1-C4 alkil, C1-C4 haloalkil, C1-C4 alkoksi, fenoksi, C1-C4 alkoksimetil, fenoksimetil ali fenil, neobvezno substituiran z 1 nitro, 1-3 halogeni, 1-3 C1-C4 alkil, ali 1-3 C1-C4 alkoksi; R4 je metil, etil ali izopropil; X je kisik, NOR6 ali N-NHR7; R6 je vodik, C1-C4 alkil, C1-C4 alkoksimetil, C1-C4 alkanoil, benzil ali fenil; in R7 je C1-C4 acil, C1-C4 alkil ali benzoil. 5 r. m · · · r e f, f # 9 i* c * β · • « c · ·. · e r- · • r r * r r r c
7. Spojina po zahtevku 6, značilna po tem, da je Ri metil, etil ali izopropil; R.2 metil; R3 je vodik, C1-C4 alkil, ali 0 II c—r5 ; R5 je vodik, Cx-C4 alkoksimetil, C1-C4 halometil ali formil; R4 je izopropil; X je N0R6,' in R6 je C1-C4 alkil.
8. Sestavek za nadzor endo- in ektoparazitov, insektov, akaridov in nematodov, značilen po tem, da obsega agronomsko sprejemljiv nosilec, ki vsebuje profilaktično, terapevtsko, farmacevtsko ali insekticidno učinkovito količino spojine po zahtevku 6. American Cynamid Company One Cynamid Plaza Wayne, NJ 07470-8426
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/405,808 US5030650A (en) | 1989-09-11 | 1989-09-11 | 13-halo-23-imino derivatives of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents |
| US07/455,686 US5055486A (en) | 1989-12-22 | 1989-12-22 | 13-alkyl-23-imino derivative of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents |
| YU171090A YU47592B (sh) | 1989-09-11 | 1990-09-10 | 13-alkil-23-imino i 13-halo-23-imino derivati makrolidnih jedinjenja |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9011710A SI9011710A (sl) | 1998-02-28 |
| SI9011710B true SI9011710B (sl) | 2000-12-31 |
Family
ID=27019245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9011710A SI9011710B (sl) | 1989-09-11 | 1990-09-10 | 13-alkil-23-imino in 13-halo-23-imino derivati makrolidnih spojin |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0423445B1 (sl) |
| JP (1) | JP3026827B2 (sl) |
| KR (2) | KR0160972B1 (sl) |
| CN (2) | CN1032004C (sl) |
| AT (1) | ATE130006T1 (sl) |
| AU (1) | AU631454B2 (sl) |
| BG (1) | BG60271B1 (sl) |
| BR (1) | BR9004494A (sl) |
| DE (1) | DE69023454T2 (sl) |
| DK (1) | DK0423445T3 (sl) |
| ES (1) | ES2081880T3 (sl) |
| GR (1) | GR3018033T3 (sl) |
| HU (1) | HU217357B (sl) |
| IE (1) | IE71210B1 (sl) |
| IL (1) | IL109791A (sl) |
| PL (1) | PL164168B1 (sl) |
| PT (1) | PT95241B (sl) |
| RU (1) | RU2070885C1 (sl) |
| SI (1) | SI9011710B (sl) |
| UA (1) | UA41246C2 (sl) |
| YU (1) | YU47592B (sl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4988824A (en) * | 1989-09-11 | 1991-01-29 | Maulding Donald R | Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds |
| US5229416A (en) * | 1992-04-29 | 1993-07-20 | Merck & Co., Inc. | Avermectin difluoro derivatives |
| DE19654079A1 (de) | 1996-12-23 | 1998-06-25 | Bayer Ag | Endo-ekto-parasitizide Mittel |
| DE102004053964A1 (de) | 2004-11-09 | 2006-05-11 | Bayer Healthcare Ag | Mittel gegen Demodikose |
| CN106831811B (zh) * | 2015-08-12 | 2018-10-26 | 内蒙古佳瑞米精细化工有限公司 | 一种制备高含量尼莫克汀的方法 |
| US20210137960A1 (en) | 2018-02-01 | 2021-05-13 | Yale University | Compositions and methods for inhibition of nuclear-penetrating antibodies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0253378A3 (de) * | 1986-07-18 | 1988-03-23 | Ciba-Geigy Ag | 13Beta-Alkyl-derivate von S541-Antibiotika zur Bekämpfung von Parasiten an Nutztieren und Pflanzen |
| ES2058082T3 (es) * | 1986-09-12 | 1994-11-01 | American Cyanamid Co | Derivados 23-oxo (ceto) y 23-imino de compuestos ll-f28249. |
| US4831016A (en) * | 1986-10-31 | 1989-05-16 | Merck & Co., Inc. | Reduced avermectin derivatives |
| US4886829A (en) * | 1987-03-06 | 1989-12-12 | American Cyanamid Company | 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds |
| US4806527A (en) * | 1987-03-16 | 1989-02-21 | Merck & Co., Inc. | Avermectin derivatives |
| US5830875A (en) * | 1989-10-30 | 1998-11-03 | Merck & Co., Inc. | 24-and 25-substituted avermectin and milbemycin derivatives |
-
1990
- 1990-08-03 AT AT90114920T patent/ATE130006T1/de not_active IP Right Cessation
- 1990-08-03 EP EP90114920A patent/EP0423445B1/en not_active Expired - Lifetime
- 1990-08-03 ES ES90114920T patent/ES2081880T3/es not_active Expired - Lifetime
- 1990-08-03 DK DK90114920.3T patent/DK0423445T3/da active
- 1990-08-03 DE DE69023454T patent/DE69023454T2/de not_active Expired - Lifetime
- 1990-08-06 IL IL10979190A patent/IL109791A/en not_active IP Right Cessation
- 1990-08-30 CN CN90107011A patent/CN1032004C/zh not_active Expired - Fee Related
- 1990-09-07 PT PT95241A patent/PT95241B/pt not_active IP Right Cessation
- 1990-09-07 JP JP2235957A patent/JP3026827B2/ja not_active Expired - Lifetime
- 1990-09-10 IE IE327490A patent/IE71210B1/en not_active IP Right Cessation
- 1990-09-10 RU SU904831124A patent/RU2070885C1/ru not_active IP Right Cessation
- 1990-09-10 YU YU171090A patent/YU47592B/sh unknown
- 1990-09-10 AU AU62357/90A patent/AU631454B2/en not_active Expired
- 1990-09-10 PL PL90286823A patent/PL164168B1/pl unknown
- 1990-09-10 KR KR1019900014282A patent/KR0160972B1/ko not_active IP Right Cessation
- 1990-09-10 BR BR909004494A patent/BR9004494A/pt not_active IP Right Cessation
- 1990-09-10 BG BG092811A patent/BG60271B1/bg unknown
- 1990-09-10 UA UA4831124A patent/UA41246C2/uk unknown
- 1990-09-10 HU HU844/90A patent/HU217357B/hu not_active IP Right Cessation
- 1990-09-10 SI SI9011710A patent/SI9011710B/sl not_active IP Right Cessation
-
1994
- 1994-11-24 CN CN94118512A patent/CN1053556C/zh not_active Expired - Fee Related
-
1995
- 1995-11-09 GR GR940403514T patent/GR3018033T3/el unknown
-
1998
- 1998-06-23 KR KR1019980023560A patent/KR0168751B1/ko not_active IP Right Cessation
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| IF | Valid on the event date | ||
| KO00 | Lapse of patent |
Effective date: 20050610 |