YU46863B - Postupak za dobijanje spiro-azolonskog jedinjenja - Google Patents

Postupak za dobijanje spiro-azolonskog jedinjenja

Info

Publication number
YU46863B
YU46863B YU167788A YU167788A YU46863B YU 46863 B YU46863 B YU 46863B YU 167788 A YU167788 A YU 167788A YU 167788 A YU167788 A YU 167788A YU 46863 B YU46863 B YU 46863B
Authority
YU
Yugoslavia
Prior art keywords
compound
spiro
azolone
hydrogen
structural formula
Prior art date
Application number
YU167788A
Other languages
English (en)
Serbian (sr)
Other versions
YU167788A (en
Inventor
S.W. Goldstein
R. Sarges
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU167788A publication Critical patent/YU167788A/xx
Publication of YU46863B publication Critical patent/YU46863B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE SPIRO-AZOLONSKOG JEDINJENJA, u kojoj je X vodonik, fluor, hlor, brom, nitro, trifluormetil, C1-C4 alkil, C1-C4 alkoksi ili C1-C4alkiltio, Z je imino, Y je kiseonik ili sumpor i R je vodonik ili C1-C4 alkil, a -A=B-D=E- predstavlja -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- ili -CH=CH-CH=N-ili N-oksidni derivat istog, naznačen time, što obihvata kondenzovanje supstituisanog karbonil prstenastog jedinjenja: u kojme X, Y, i R i -A=B-D=E- su svaki kao što je prethodno definisano sa cijanidom alkalnog metala i amonijum karbonatom radi obrazovanja željenog spiro-imidazolidindion finalnog proizvoda strukturne formule (I) u odgovarajuće nesupstituisano prstenasto-dehalo jedinjenje u kome je X vodonik i ako je potrebno, oksidacija jedinjenja strukturne formule (I) radi obrazovanja odgovarajućeg N-oksidnog derivata istog i što se, ako se želi, vrši pretvaranje spiro-azolonskog jedinjenja strukturne formule (I) u njegovu baznu so sa farmakološki prihvatljivim katjonom. Prijava sadrži još 5 zavisnih zahteva.
YU167788A 1987-09-04 1988-09-02 Postupak za dobijanje spiro-azolonskog jedinjenja YU46863B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1987/002196 WO1989001775A1 (en) 1987-09-04 1987-09-04 Azolidinedione derivatives

Publications (2)

Publication Number Publication Date
YU167788A YU167788A (en) 1990-06-30
YU46863B true YU46863B (sh) 1994-06-24

Family

ID=22202540

Family Applications (1)

Application Number Title Priority Date Filing Date
YU167788A YU46863B (sh) 1987-09-04 1988-09-02 Postupak za dobijanje spiro-azolonskog jedinjenja

Country Status (21)

Country Link
EP (1) EP0306251A3 (sh)
JP (1) JPS6471882A (sh)
KR (1) KR900008841B1 (sh)
CN (1) CN1022325C (sh)
AU (1) AU595467B2 (sh)
CS (1) CS273186B2 (sh)
DD (1) DD273381A5 (sh)
DK (1) DK488688A (sh)
EG (1) EG18591A (sh)
FI (1) FI901087A0 (sh)
HU (1) HU204832B (sh)
IL (1) IL87590A (sh)
MX (1) MX12896A (sh)
MY (1) MY103765A (sh)
NO (1) NO901016L (sh)
PH (1) PH24957A (sh)
PL (1) PL156798B1 (sh)
PT (1) PT88407B (sh)
WO (1) WO1989001775A1 (sh)
YU (1) YU46863B (sh)
ZA (1) ZA886507B (sh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5068333A (en) * 1990-03-07 1991-11-26 Pfizer Inc. 6-chloro-3,4-dihydro-pyrano [2,3-b]pyridines having the R configuration
DE10210195B4 (de) 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
PL1873145T3 (pl) 2005-04-21 2013-02-28 Ishihara Sangyo Kaisha Sposób wytwarzania pochodnej kwasu nikotynowego lub jego soli

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4176185A (en) * 1979-01-22 1979-11-27 Pfizer Inc. Spiro-quinolylhydantoins
US4226875A (en) * 1979-04-02 1980-10-07 Pfizer Inc. Novel spiro-oxazolidinediones
FR2455046A1 (fr) * 1979-04-25 1980-11-21 Science Union & Cie Nouvelles hydantoines, leur procede de preparation et leur emploi comme medicament
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
DE3262294D1 (en) * 1981-05-13 1985-03-28 Ici Plc Pharmaceutical compositions containing spiro succinimide derivatives

Also Published As

Publication number Publication date
AU595467B2 (en) 1990-03-29
CS591188A2 (en) 1990-06-13
IL87590A0 (en) 1989-01-31
HU204832B (en) 1992-02-28
DD273381A5 (de) 1989-11-15
YU167788A (en) 1990-06-30
NO901016L (no) 1990-05-02
NO901016D0 (no) 1990-03-02
CS273186B2 (en) 1991-03-12
IL87590A (en) 1992-07-15
MY103765A (en) 1993-09-30
PT88407B (pt) 1992-10-30
PT88407A (pt) 1989-07-31
JPS6471882A (en) 1989-03-16
HUT56106A (en) 1991-07-29
DK488688D0 (da) 1988-09-02
JPH0583554B2 (sh) 1993-11-26
EP0306251A2 (en) 1989-03-08
CN1031702A (zh) 1989-03-15
MX12896A (es) 1993-06-01
EP0306251A3 (en) 1990-08-01
PL156798B1 (pl) 1992-04-30
EG18591A (en) 1993-06-30
FI901087A0 (fi) 1990-03-02
PH24957A (en) 1990-12-26
AU2184188A (en) 1989-03-09
KR900008841B1 (ko) 1990-11-30
ZA886507B (en) 1990-04-25
CN1022325C (zh) 1993-10-06
PL274504A1 (en) 1989-05-02
DK488688A (da) 1989-04-07
WO1989001775A1 (en) 1989-03-09
KR890005112A (ko) 1989-05-11

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