YU39593A - Derivati hidroksamne kiseline - Google Patents
Derivati hidroksamne kiselineInfo
- Publication number
- YU39593A YU39593A YU39593A YU39593A YU39593A YU 39593 A YU39593 A YU 39593A YU 39593 A YU39593 A YU 39593A YU 39593 A YU39593 A YU 39593A YU 39593 A YU39593 A YU 39593A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- lower alkyl
- carbamoyl
- oxo
- group
- atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/43—Indoles; Hydrogenated indoles with an —OCH2CH(OH)CH2NH2 radical, which may be further substituted, attached in positions 4, 5, 6 or 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
DERIVATI HIDROKSAMNE KISELINE sa formulom u kojoj R1 predstavlja 5- ili 6-točlani N-heterociklični prsten koji je (a) vezan preko N atoma, (b) po potrebi sadrži N, O i/ili S kao dodatne hetero atome u položaju koji nije susedan veznom N atomu, (c) je zamenjen sa okso ili jednim oli oba C atoma susednih veznom N atomu i (d) je po potrebi vezan benz-vezom ili po potrebi zamenjen na jednom ili vise C atoma sa nižom alkil ili okso i/ili sa bilo kojim dodatnim N atomom (ima) sa nižom alkil ili aril grupom; R2 predstavlja nižu alkil a R3 predstavlja nižu alkil ili aril grupu, ili NR2R3 predstavlja zasićeni 5-, 6- ili 7-močlani heterociklični prsten, koji po potrebi sadrži -NRa-, -0-, -S-, -SO- ili -S02- kao člana prstena i/ili koji je po potrebi zamenjen sa hidroksi, nižom alkok-si.okso, ketalizovanom okso, amino, mono (niži alkil) amino, di(niži alkil) amino, karboksi, nižom alkoksikarbonil, hidrok-simeul, nižom alkoksimetil, karbamojl. mono (niži alkil) kar-bamojl, di(niži alkil)karbamojl ili todroksiimino grupom; Ra predstavlja vodonik, nižu alkil, nižualkanojl, aril-nižu alkanojl, nižu alkoksikarbonil, aril-nižu alkoksikarbonil ili mono(niži alkil)karbamojl grupu; R4, R5, R6 i R7 svaki predstavljaju vodonik ili metil, pod uslovom da su bar dva od ovih simbol vodonik; a n znači 1 - 4; i farmaceutske njihove soli, koji su inhibitori kolageneze i korisni ža kontrolu ili sprečavanje degenerativnih oboljenja zglobova kao što je reumatski artritis i osteoartritis ili za tretman invazionih tumora, ateroskleroze ili multiple skleroze. Oni mogu biti proizvođeni bilo hidroksamidovanjem odgovarajuće nove karboksilne kiseline ili skidanjem zaštite sa odgovarajućeg novog benziloksi-karbamojl jedinjenja.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929212421A GB9212421D0 (en) | 1992-06-11 | 1992-06-11 | Hydroxamic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU39593A true YU39593A (sh) | 1997-08-22 |
Family
ID=10716942
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU39593A YU39593A (sh) | 1992-06-11 | 1993-06-04 | Derivati hidroksamne kiseline |
Country Status (11)
| Country | Link |
|---|---|
| KR (1) | KR940005571A (xx) |
| GB (2) | GB9212421D0 (xx) |
| HR (1) | HRP930978A2 (xx) |
| MX (1) | MX9303391A (xx) |
| PL (1) | PL299261A1 (xx) |
| RO (1) | RO112613B1 (xx) |
| SI (1) | SI9300289A (xx) |
| TW (1) | TW237444B (xx) |
| UY (1) | UY23599A1 (xx) |
| YU (1) | YU39593A (xx) |
| ZA (1) | ZA933957B (xx) |
-
1992
- 1992-06-11 GB GB929212421A patent/GB9212421D0/en active Pending
-
1993
- 1993-03-19 GB GB939305720A patent/GB9305720D0/en active Pending
- 1993-05-15 TW TW082103831A patent/TW237444B/zh active
- 1993-05-28 SI SI9300289A patent/SI9300289A/sl unknown
- 1993-06-04 RO RO93-00777A patent/RO112613B1/ro unknown
- 1993-06-04 YU YU39593A patent/YU39593A/sh unknown
- 1993-06-04 ZA ZA933957A patent/ZA933957B/xx unknown
- 1993-06-07 MX MX9303391A patent/MX9303391A/es unknown
- 1993-06-09 PL PL29926193A patent/PL299261A1/xx unknown
- 1993-06-10 KR KR1019930010559A patent/KR940005571A/ko not_active Application Discontinuation
- 1993-06-10 HR HR9212421.3A patent/HRP930978A2/hr not_active Application Discontinuation
- 1993-06-10 UY UY23599A patent/UY23599A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO112613B1 (ro) | 1997-11-28 |
| UY23599A1 (es) | 1993-12-01 |
| TW237444B (xx) | 1995-01-01 |
| SI9300289A (sl) | 1993-12-31 |
| HRP930978A2 (en) | 1997-04-30 |
| MX9303391A (es) | 1994-06-30 |
| GB9212421D0 (en) | 1992-07-22 |
| GB9305720D0 (en) | 1993-05-05 |
| PL299261A1 (en) | 1994-01-10 |
| KR940005571A (ko) | 1994-03-21 |
| ZA933957B (en) | 1993-12-13 |
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