YU39499B - Process for the manufacture of optically active substituted azabicyclohexanes - Google Patents
Process for the manufacture of optically active substituted azabicyclohexanesInfo
- Publication number
- YU39499B YU39499B YU2174/77A YU217477A YU39499B YU 39499 B YU39499 B YU 39499B YU 2174/77 A YU2174/77 A YU 2174/77A YU 217477 A YU217477 A YU 217477A YU 39499 B YU39499 B YU 39499B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- manufacture
- optically active
- active substituted
- azabicyclohexanes
- substituted azabicyclohexanes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/40—Unsaturated compounds containing halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/28—Unsaturated compounds polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72340276A | 1976-09-15 | 1976-09-15 | |
| US05/809,340 US4118417A (en) | 1977-06-23 | 1977-06-23 | Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids |
| US05/809,341 US4118393A (en) | 1977-06-23 | 1977-06-23 | Phenyl azabicyclohexanones |
| US05/809,339 US4131611A (en) | 1975-07-31 | 1977-06-23 | Azabicyclohexanes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU217477A YU217477A (en) | 1983-01-21 |
| YU39499B true YU39499B (en) | 1984-12-31 |
Family
ID=27505564
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU2174/77A YU39499B (en) | 1976-09-15 | 1977-09-13 | Process for the manufacture of optically active substituted azabicyclohexanes |
| YU1885/82A YU43523B (en) | 1976-09-15 | 1982-08-23 | Process for obtaining optically active substituted azabicyclohexanes |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU1885/82A YU43523B (en) | 1976-09-15 | 1982-08-23 | Process for obtaining optically active substituted azabicyclohexanes |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5337656A (pt) |
| AR (2) | AR220684A1 (pt) |
| AT (2) | AT367036B (pt) |
| AU (1) | AU519620B2 (pt) |
| BE (1) | BE858683A (pt) |
| CH (2) | CH637929A5 (pt) |
| DD (1) | DD133943A5 (pt) |
| DE (1) | DE2740562A1 (pt) |
| DK (3) | DK146245C (pt) |
| FR (1) | FR2375212A1 (pt) |
| GR (1) | GR72713B (pt) |
| HU (1) | HU177531B (pt) |
| NL (1) | NL189041C (pt) |
| PL (1) | PL115869B1 (pt) |
| SE (2) | SE435384B (pt) |
| YU (2) | YU39499B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4183857A (en) * | 1978-07-06 | 1980-01-15 | Shell Oil Company | 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione |
| IL65843A (en) * | 1977-08-11 | 1986-12-31 | American Cyanamid Co | Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type |
| CA1117127A (en) * | 1978-06-27 | 1982-01-26 | Janet A. Day | Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation |
| US4225499A (en) * | 1978-07-06 | 1980-09-30 | Shell Oil Company | Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile |
| JPS6332100A (ja) * | 1986-07-25 | 1988-02-10 | 東京電力株式会社 | シ−ルド掘進機 |
| JPH0658037B2 (ja) * | 1989-09-01 | 1994-08-03 | 日本鋼管株式会社 | シールド掘進装置 |
| US6372919B1 (en) | 2001-01-11 | 2002-04-16 | Dov Pharmaceutical, Inc. | (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent |
| US6569887B2 (en) | 2001-08-24 | 2003-05-27 | Dov Pharmaceuticals Inc. | (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake |
| US20080081834A1 (en) | 2002-07-31 | 2008-04-03 | Lippa Arnold S | Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders |
| CN101014337A (zh) * | 2004-07-22 | 2007-08-08 | 惠氏公司 | 治疗神经系统障碍和病症的方法 |
| CA2574310A1 (en) * | 2004-07-22 | 2006-02-02 | Wyeth | Method for treating nervous system disorders and conditions |
| US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
| RU2008107336A (ru) | 2005-07-27 | 2009-09-10 | Дов Фармасьютикал, Инк. (Us) | Новые 1-арил-з-азабицикло{3.1.0.} гексаны: получение и применение для лечения психоневрологических расстройств |
| US20080045725A1 (en) | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
| US8138377B2 (en) | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
| US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| US20140206740A1 (en) | 2011-07-30 | 2014-07-24 | Neurovance, Inc. | Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1351754A (en) * | 1970-07-02 | 1974-05-01 | Allen & Hanburys Ltd | Indenopyrrole derivatives |
-
1977
- 1977-08-16 GR GR54169A patent/GR72713B/el unknown
- 1977-08-26 AR AR268968A patent/AR220684A1/es active
- 1977-09-01 AU AU28441/77A patent/AU519620B2/en not_active Ceased
- 1977-09-02 NL NLAANVRAGE7709691,A patent/NL189041C/xx not_active IP Right Cessation
- 1977-09-08 DE DE19772740562 patent/DE2740562A1/de active Granted
- 1977-09-13 CH CH1118977A patent/CH637929A5/de not_active IP Right Cessation
- 1977-09-13 YU YU2174/77A patent/YU39499B/xx unknown
- 1977-09-14 PL PL1977200831A patent/PL115869B1/pl unknown
- 1977-09-14 BE BE180894A patent/BE858683A/xx not_active IP Right Cessation
- 1977-09-14 FR FR7727755A patent/FR2375212A1/fr active Granted
- 1977-09-14 DK DK407577A patent/DK146245C/da not_active IP Right Cessation
- 1977-09-14 AT AT0661577A patent/AT367036B/de not_active IP Right Cessation
- 1977-09-14 HU HU77AE508A patent/HU177531B/hu unknown
- 1977-09-15 DD DD77201039A patent/DD133943A5/xx unknown
- 1977-09-15 SE SE7710367A patent/SE435384B/xx not_active IP Right Cessation
- 1977-09-16 JP JP11064777A patent/JPS5337656A/ja active Granted
-
1978
- 1978-09-19 AR AR273764A patent/AR227507A1/es active
-
1980
- 1980-05-30 AT AT0288280A patent/AT367037B/de not_active IP Right Cessation
- 1980-10-16 DK DK438580A patent/DK438580A/da not_active Application Discontinuation
- 1980-10-16 DK DK438480A patent/DK438480A/da not_active Application Discontinuation
-
1982
- 1982-04-05 CH CH209382A patent/CH637931A5/de not_active IP Right Cessation
- 1982-06-03 SE SE8203437A patent/SE452610B/sv not_active IP Right Cessation
- 1982-08-23 YU YU1885/82A patent/YU43523B/xx unknown
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