YU38695A - Novi derivati 1,1-bis(heteroazolil)alkana postupci njihovog dobijanja i farmaceutski preparati koji sadrže ova jedinjenja kao sredstva za neurološku zaštitu - Google Patents
Novi derivati 1,1-bis(heteroazolil)alkana postupci njihovog dobijanja i farmaceutski preparati koji sadrže ova jedinjenja kao sredstva za neurološku zaštituInfo
- Publication number
- YU38695A YU38695A YU38695A YU38695A YU38695A YU 38695 A YU38695 A YU 38695A YU 38695 A YU38695 A YU 38695A YU 38695 A YU38695 A YU 38695A YU 38695 A YU38695 A YU 38695A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- lower alkyl
- independently
- compounds
- novel
- heteroazolyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Sadašnji pronalazak se odnosi na nova heterociklična jedinjenja opšte formule (1) u kojoj su: X1 i X2, nezavisno, O, S ili Se; Y1 i Y2, nezavisno, C ili N, pod uslovom da je bar jedan od Y1, ili Y2 N; Y3 i Y4, nezavisno, C ili N, pod uslovom da je bar jedan od Y3 ili Y4 N; R1 i R2 predstavljaju jednu ili više grupa koje se nezavisno izabiru između H, niži alkil, nižialkoksi-niži alkil, hidroksi-niži alciloksi-niži alkil, ili CF3; WR3 R a A je C ili C = C R4 R6 gde su W O. S. NH ili N-niži alkil, R3 je H, niži alkil ili niži acil, ili je WR3 H, R4 je niži alkil ili niži perfluoroalkil, ili R3 i R4 zajedno formiraju prsten gde je n 2, 3 ili 4, R5 i R6, nezavisno, su H ili niži alkil, geometrijski i optički izomeri i njihovi racemati, ukoliko takvi izomeri postoje, kao i njihove farmaceutski prihvatljive kisele adicione soli i njihovi solvati; koja imaju lekovito dejstvo, zatim postupci i intermedijari za njihovo dobijanje, farmaceutske fomulacije koje sadrže pomenuta jedinjenja i upotreba u medicini pomenutih jedinjenja.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9401965A SE9401965D0 (sv) | 1994-06-07 | 1994-06-07 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU38695A true YU38695A (sh) | 1998-12-23 |
Family
ID=20394274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU38695A YU38695A (sh) | 1994-06-07 | 1995-06-07 | Novi derivati 1,1-bis(heteroazolil)alkana postupci njihovog dobijanja i farmaceutski preparati koji sadrže ova jedinjenja kao sredstva za neurološku zaštitu |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US5843971A (sh) |
| EP (1) | EP0765325A1 (sh) |
| JP (1) | JPH10503172A (sh) |
| CN (1) | CN1051546C (sh) |
| AU (1) | AU691303B2 (sh) |
| BR (1) | BR9507923A (sh) |
| CA (1) | CA2190128A1 (sh) |
| CZ (1) | CZ357796A3 (sh) |
| DZ (1) | DZ1895A1 (sh) |
| EE (1) | EE9600197A (sh) |
| FI (1) | FI964879A (sh) |
| HR (1) | HRP950302A2 (sh) |
| HU (1) | HUT76050A (sh) |
| IL (1) | IL113773A (sh) |
| IS (1) | IS4383A (sh) |
| MA (1) | MA23574A1 (sh) |
| NO (1) | NO307421B1 (sh) |
| NZ (1) | NZ287973A (sh) |
| PL (1) | PL318470A1 (sh) |
| RU (1) | RU2155763C2 (sh) |
| SE (1) | SE9401965D0 (sh) |
| SK (1) | SK155696A3 (sh) |
| TN (1) | TNSN95065A1 (sh) |
| WO (1) | WO1995033747A1 (sh) |
| YU (1) | YU38695A (sh) |
| ZA (1) | ZA954145B (sh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9401965D0 (sv) * | 1994-06-07 | 1994-06-07 | Astra Ab | New compounds |
| US6921538B2 (en) * | 2002-05-10 | 2005-07-26 | Allergan, Inc. | Therapeutic treatments for neuropsychiatric disorders |
| US7649098B2 (en) * | 2006-02-24 | 2010-01-19 | Lexicon Pharmaceuticals, Inc. | Imidazole-based compounds, compositions comprising them and methods of their use |
| TW200920355A (en) * | 2007-09-06 | 2009-05-16 | Lexicon Pharmaceuticals Inc | Compositions and methods for treating immunological and inflammatory diseases and disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2801794A1 (de) * | 1978-01-17 | 1979-07-19 | Basf Ag | Verfahren zur herstellung von thiazolderivaten und neue thiazole |
| US5554620A (en) * | 1993-09-14 | 1996-09-10 | Sterling Winthrop Inc. | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof |
| SE9401965D0 (sv) * | 1994-06-07 | 1994-06-07 | Astra Ab | New compounds |
-
1994
- 1994-06-07 SE SE9401965A patent/SE9401965D0/xx unknown
-
1995
- 1995-05-18 IL IL11377395A patent/IL113773A/xx not_active IP Right Cessation
- 1995-05-22 ZA ZA954145A patent/ZA954145B/xx unknown
- 1995-05-22 HR HR9401965-0A patent/HRP950302A2/xx not_active Application Discontinuation
- 1995-05-29 AU AU26859/95A patent/AU691303B2/en not_active Ceased
- 1995-05-29 RU RU97100178/04A patent/RU2155763C2/ru active
- 1995-05-29 CA CA002190128A patent/CA2190128A1/en not_active Abandoned
- 1995-05-29 NZ NZ287973A patent/NZ287973A/en unknown
- 1995-05-29 CN CN95193504A patent/CN1051546C/zh not_active Expired - Fee Related
- 1995-05-29 JP JP8500744A patent/JPH10503172A/ja active Pending
- 1995-05-29 EE EE9600197A patent/EE9600197A/xx unknown
- 1995-05-29 WO PCT/SE1995/000604 patent/WO1995033747A1/en not_active Application Discontinuation
- 1995-05-29 HU HU9603386A patent/HUT76050A/hu unknown
- 1995-05-29 SK SK1556-96A patent/SK155696A3/sk unknown
- 1995-05-29 PL PL95318470A patent/PL318470A1/xx unknown
- 1995-05-29 CZ CZ963577A patent/CZ357796A3/cs unknown
- 1995-05-29 US US08/448,411 patent/US5843971A/en not_active Expired - Fee Related
- 1995-05-29 EP EP95922031A patent/EP0765325A1/en not_active Ceased
- 1995-05-29 BR BR9507923A patent/BR9507923A/pt not_active Application Discontinuation
- 1995-06-01 MA MA23913A patent/MA23574A1/fr unknown
- 1995-06-06 TN TNTNSN95065A patent/TNSN95065A1/fr unknown
- 1995-06-07 US US08/485,719 patent/US5665747A/en not_active Expired - Fee Related
- 1995-06-07 YU YU38695A patent/YU38695A/sh unknown
- 1995-07-03 DZ DZ950069A patent/DZ1895A1/fr active
-
1996
- 1996-11-12 IS IS4383A patent/IS4383A/is unknown
- 1996-12-04 NO NO965182A patent/NO307421B1/no not_active IP Right Cessation
- 1996-12-05 FI FI964879A patent/FI964879A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA23574A1 (fr) | 1995-12-31 |
| CN1150426A (zh) | 1997-05-21 |
| HRP950302A2 (en) | 1997-08-31 |
| SE9401965D0 (sv) | 1994-06-07 |
| FI964879A0 (fi) | 1996-12-05 |
| NZ287973A (en) | 1998-04-27 |
| US5843971A (en) | 1998-12-01 |
| EE9600197A (et) | 1997-06-16 |
| IL113773A (en) | 2000-02-29 |
| NO965182D0 (no) | 1996-12-04 |
| CZ357796A3 (en) | 1997-06-11 |
| CN1051546C (zh) | 2000-04-19 |
| HUT76050A (en) | 1997-06-30 |
| HU9603386D0 (en) | 1997-01-28 |
| BR9507923A (pt) | 1997-09-23 |
| TNSN95065A1 (fr) | 1996-02-06 |
| SK155696A3 (en) | 1997-05-07 |
| DZ1895A1 (fr) | 2002-02-17 |
| WO1995033747A1 (en) | 1995-12-14 |
| JPH10503172A (ja) | 1998-03-24 |
| IL113773A0 (en) | 1995-08-31 |
| FI964879A (fi) | 1996-12-05 |
| PL318470A1 (en) | 1997-06-23 |
| EP0765325A1 (en) | 1997-04-02 |
| NO965182L (no) | 1996-12-04 |
| ZA954145B (en) | 1995-12-07 |
| AU2685995A (en) | 1996-01-04 |
| NO307421B1 (no) | 2000-04-03 |
| CA2190128A1 (en) | 1995-12-14 |
| AU691303B2 (en) | 1998-05-14 |
| IS4383A (is) | 1996-11-12 |
| RU2155763C2 (ru) | 2000-09-10 |
| US5665747A (en) | 1997-09-09 |
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