YU188890A - Derivati hromana - Google Patents

Derivati hromana

Info

Publication number
YU188890A
YU188890A YU188890A YU188890A YU188890A YU 188890 A YU188890 A YU 188890A YU 188890 A YU188890 A YU 188890A YU 188890 A YU188890 A YU 188890A YU 188890 A YU188890 A YU 188890A
Authority
YU
Yugoslavia
Prior art keywords
derivatives
general formula
6alkyl
hromana
ch2oh
Prior art date
Application number
YU188890A
Other languages
English (en)
Inventor
G. Rolf
B. Manfred
L. Ingeborg
P. Jacques
B. Rolf
Original Assignee
Merck Patent Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh. filed Critical Merck Patent Gmbh.
Publication of YU188890A publication Critical patent/YU188890A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)

Abstract

DERIVATI HROMANA, pronalazak se odnosi na derivate hromana opšte formule I i na postupak za njihovo dobivanje: gde X je O ili NR11, Z je CH2, O,S ili CHHal, R1 i R5 su C1-6alkil, R2 je H ili C1-6alkil, R3 je OH ili OAc, gde Ac je C1-8 alkanoil ili C7-11 aroil, R4 je H,R6 i R7 su H,HO, CHO; HOOC, hidroksialkil, NO2, NH2, CN, Cl, CF3 R8 i R9 su H, R10 je H,CHO ili CH2OH i R11 je C1-6alkil, Ac ili CH2OH. Postupak za dobivanje derivata opšte formule I obuhvata reakciju 3,4-epoksihromana opšte formule II sa nekim jedinjenjem opšte formule III gde svi navedeni supstituenti imaju napred data značenja.
YU188890A 1989-10-09 1990-10-05 Derivati hromana YU188890A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3933663A DE3933663A1 (de) 1989-10-09 1989-10-09 Chromanderivate

Publications (1)

Publication Number Publication Date
YU188890A true YU188890A (sh) 1993-10-20

Family

ID=6391105

Family Applications (1)

Application Number Title Priority Date Filing Date
YU188890A YU188890A (sh) 1989-10-09 1990-10-05 Derivati hromana

Country Status (15)

Country Link
EP (1) EP0422450A3 (sh)
JP (1) JPH03133973A (sh)
KR (1) KR910007907A (sh)
AU (1) AU633983B2 (sh)
CA (1) CA2027097A1 (sh)
DE (1) DE3933663A1 (sh)
FI (1) FI904933A0 (sh)
HU (1) HU208126B (sh)
IE (1) IE903591A1 (sh)
IL (1) IL95927A0 (sh)
NO (1) NO904362L (sh)
NZ (1) NZ235597A (sh)
PT (1) PT95530A (sh)
YU (1) YU188890A (sh)
ZA (1) ZA908091B (sh)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH674984A5 (sh) * 1987-05-16 1990-08-15 Sandoz Ag

Also Published As

Publication number Publication date
NO904362D0 (no) 1990-10-08
AU633983B2 (en) 1993-02-11
ZA908091B (en) 1991-08-28
HUT58714A (en) 1992-03-30
PT95530A (pt) 1991-08-14
CA2027097A1 (en) 1991-04-10
HU208126B (en) 1993-08-30
NO904362L (no) 1991-04-10
IE903591A1 (en) 1991-04-10
IL95927A0 (en) 1991-07-18
DE3933663A1 (de) 1991-04-11
KR910007907A (ko) 1991-05-30
EP0422450A3 (en) 1991-09-25
JPH03133973A (ja) 1991-06-07
EP0422450A2 (de) 1991-04-17
FI904933A0 (fi) 1990-10-08
HU906385D0 (en) 1991-04-29
NZ235597A (en) 1992-07-28
AU6391590A (en) 1991-04-11

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