YU172991A - Sinergizam inhibitora hiv reverzne transkriptaze - Google Patents

Sinergizam inhibitora hiv reverzne transkriptaze

Info

Publication number
YU172991A
YU172991A YU172991A YU172991A YU172991A YU 172991 A YU172991 A YU 172991A YU 172991 A YU172991 A YU 172991A YU 172991 A YU172991 A YU 172991A YU 172991 A YU172991 A YU 172991A
Authority
YU
Yugoslavia
Prior art keywords
reverse transcriptase
synergism
hiv
hiv reverse
combination
Prior art date
Application number
YU172991A
Other languages
English (en)
Serbian (sr)
Inventor
A.P. Friedman
A.E. Emini
J. Hunberg
C.J. Quintero
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of YU172991A publication Critical patent/YU172991A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

SINERGIZAM INHIBITORA HIV REVERZNE TRANSKRIPTAZE, kombinacija izvesnih aminopiridona i analoga anti-HIV nukleozida otkriveno je da sinergično koči HIV reversnu transkriptazu. Ova kombinacija je korisna za sprečavanje ili lečenje infekcije HIV-om i lečenje AIDS, ili kao kombinacija jedinjenja, farmaceutski prihvatljivih soli, farmaceutskih sastojaka sastava, bilo ili ne u daljoj kombinaciji sa drugim antivirusnim sredstvima, anti-infektivnim sredstvima, imunomodulatorima, antibioticima ili vakcinama. Postupci lečenja AIDS i postupci sprečavanja ili lečenja infekcije HIV-om su takodje opisani.
YU172991A 1990-11-01 1991-10-30 Sinergizam inhibitora hiv reverzne transkriptaze YU172991A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60810490A 1990-11-01 1990-11-01
US64585791A 1991-01-25 1991-01-25

Publications (1)

Publication Number Publication Date
YU172991A true YU172991A (sh) 1994-06-24

Family

ID=27085675

Family Applications (1)

Application Number Title Priority Date Filing Date
YU172991A YU172991A (sh) 1990-11-01 1991-10-30 Sinergizam inhibitora hiv reverzne transkriptaze

Country Status (15)

Country Link
EP (1) EP0484071A3 (sh)
JP (1) JPH04300834A (sh)
KR (1) KR920009394A (sh)
CN (1) CN1062138A (sh)
AU (1) AU648121B2 (sh)
CA (1) CA2054529A1 (sh)
CS (1) CS331091A3 (sh)
FI (1) FI915152A (sh)
HU (1) HUT60135A (sh)
IE (1) IE913751A1 (sh)
IL (1) IL99843A0 (sh)
MX (1) MX9101880A (sh)
NZ (1) NZ240407A (sh)
PT (1) PT99394A (sh)
YU (1) YU172991A (sh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
GB9215176D0 (en) * 1992-07-16 1992-08-26 Glaxo Group Ltd Antiviral combinations
IL106507A (en) * 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
EP0684818B1 (en) * 1993-02-22 1999-05-06 Janssen Pharmaceutica N.V. Method of reversing resistance of hiv-1 strains to zidovudine
US5968910A (en) * 1994-11-30 1999-10-19 Jan M. R. Balzarini Compositions containing two or three inhibitors of different HIV reverse transcriptases
WO1997037657A1 (fr) * 1996-04-04 1997-10-16 Shionogi & Co., Ltd. Composition anti-vih contenant un derive d'imidazole
US6469006B1 (en) * 1999-06-15 2002-10-22 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
NL1012825C2 (nl) * 1999-08-13 2001-02-23 Faculteit Geneeskunde Universi Farmaceuticum voor de behandeling van virale infecties in het bijzonder van het humane immunodeficiency virus (HIV).
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
US6573262B2 (en) 2000-07-10 2003-06-03 Bristol-Myers Sqibb Company Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
US20030207910A1 (en) 2001-02-02 2003-11-06 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
GB0720503D0 (en) 2007-10-22 2007-11-28 Angeletti P Ist Richerche Bio New compound
US8450361B2 (en) 2010-08-06 2013-05-28 Bristol-Myers Squibb Company Substituted indole and azaindole oxoacetyl piperazinamide derivatives
US8912195B2 (en) 2010-12-02 2014-12-16 Bristol-Myers Squibb Company Alkyl amides as HIV attachment inhibitors
ES2636312T3 (es) 2011-04-12 2017-10-05 VIIV Healthcare UK (No.5) Limited Derivados de tioamida, amidoxima y amidrazona como inhibidores de la fijación del VIH
US8835454B2 (en) 2011-08-29 2014-09-16 Bristol-Myers Squibb Company Fused bicyclic diamine derivatives as HIV attachment inhibitors
US8664213B2 (en) 2011-08-29 2014-03-04 Bristol-Myers Squibb Company Spiro bicyclic diamine derivatives as HIV attachment inhibitors
WO2013138436A1 (en) 2012-03-14 2013-09-19 Bristol-Myers Squibb Company Cyclolic hydrazine derivatives as hiv attachment inhibitors
CN108299428B (zh) * 2018-04-04 2019-09-27 山东大学 8-胺基-7-甲酸甲酯-吡嗪骈吡啶酮衍生物及其制备方法与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU641769B2 (en) * 1990-06-18 1993-09-30 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase

Also Published As

Publication number Publication date
FI915152A0 (fi) 1991-10-31
HU913435D0 (en) 1992-01-28
NZ240407A (en) 1994-09-27
CA2054529A1 (en) 1992-05-02
CS331091A3 (en) 1992-05-13
IL99843A0 (en) 1992-08-18
KR920009394A (ko) 1992-06-25
PT99394A (pt) 1992-09-30
AU8693491A (en) 1992-05-07
JPH04300834A (ja) 1992-10-23
FI915152A (fi) 1992-05-02
MX9101880A (es) 1992-07-08
EP0484071A2 (en) 1992-05-06
CN1062138A (zh) 1992-06-24
IE913751A1 (en) 1992-05-22
EP0484071A3 (en) 1992-11-25
HUT60135A (en) 1992-08-28
AU648121B2 (en) 1994-04-14

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