WO2025259983A1

WO2025259983A1 - Skin care compositions

Info

Publication number: WO2025259983A1
Application number: PCT/US2025/033544
Authority: WO
Inventors: Ningwei LI; Ewelina LESNIAK; Jin NAMKOONG; Aaron Cohen; Erika PAMBIANCHI; Junhong MAO; Qiang Wu; Thomas Boyd; Sayantani Goswami CHATTERJEE; Savitha RAJAGOPAL
Original assignee: Colgate Palmolive Co
Current assignee: Colgate Palmolive Co
Priority date: 2024-06-13
Filing date: 2025-06-13
Publication date: 2025-12-18
Anticipated expiration: 2026-12-13
Also published as: WO2025259954A1

Abstract

Skin care compositions are disclosed herein. In accordance with an aspect, provided is a skin care composition including a skin care composition comprising: palmitoyl sh-tripeptide-3 amide; hyaluronic acid and/or a salt thereof; a lipid mimetic; and an amino acid system.

Description

SKIN CARE COMPOSITIONS

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of priority from U.S. Provisional Patent Application No. 63/659,507, filed June 13, 2024, titled SKIN CARE COMPOSITIONS, and from U.S. Provisional Patent Application No. 63/659,589, filed June 13, 2024, titled SKIN CARE COMPOSITIONS, the content from both of which is hereby incorporated herein by reference in its entirety for all purposes.

BACKGROUND

[0002] Skin is the body's first line of defense against infections and environmental stressors. It acts as a major physical and immunological protective barrier, but also plays a critical role in temperature regulation, water holding, vitamin D production, and sensing. Its outermost surface consists of a lipid- and protein-laden cornified layer dotted with hair follicles and eccrine glands that secrete lipids, antimicrobial peptides (AMPs), enzymes, salts, etc. It harbors microbial communities living in a range of physiologically and anatomically distinct niches. Overall, this constitutes a highly heterogeneous and complex system.

[0003] Common skin diseases or disorders include pressure ulcers caused by friction and shearing, diaper or infant rashes, incontinence dermatitis and abraded, excoriated skin, eczema, psoriasis and general dermatitis, including contact dermatitis, atopic dermatitis and seborrheic dermatitis. Other common skin injuries include flame, sun, and radiation induced burns, bites from insects and animals, sports chafing and heat rash injuries, and infections from ingrown hairs or nails in the nailbed, along with dry, cracked feet, hands and extremities due to both disease and environmental factors.

[0004] The wound healing process, depending on the type of injury to the skin, is an intricate process that involves the steps of inflammation, proliferation, and remodeling. During inflammation, bacteria and debris are phagocytized and removed, and factors are released that cause the migration and division of cells involved in the proliferative phase. The proliferative phase is characterized by angiogenesis, deposition of collagen, formation of granular tissue, re- epithelialization, and wound contraction. In angiogenesis, new blood vessels are formed by vascular endothelial cells. In fibroplasia and formation of granular tissue, fibroblasts grow and form a new, provisional extracellular matrix by excreting collagen and fibronectin. Simultaneously, re-epithelialization occurs, providing a new epithelial layer. It is at this stage that oxygenation of the skin is critical to wound healing. In the remodeling phase, collagen is remodeled and realigned along tension lines and cells that are no longer needed are removed by apoptosis.

[0005] The health of wounded skin can be improved by promoting the healing process of such wound skin. In accordance with at least one aspect of the instant invention, provided is skin care compositions that promote and/or increase the healing of skin wounds and/or improve the appearance of skin.

BRIEF SUMMARY

[0006] This summary is intended merely to introduce a simplified summary of some aspects of one or more implementations of the present disclosure. Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview, nor is it intended to identify key or critical elements of the present teachings, nor to delineate the scope of the disclosure. Rather, its purpose is merely to present one or more concepts in simplified form as a prelude to the detailed description below.

[0007] The present disclosure relates skin care compositions adapted to improve the appearance and/or health of skin. For example, the inventors discovered that skin care compositions containing certain combinations of palmitoyl sh-tripeptide-3 amide, a hyaluronic acid and/or a salt thereof, a lipid mimetic, and an amino acid system can achieve enhanced wound healing. Additionally, it was unexpectedly discovered that skin care compositions comprising specific combinations of palmitoyl sh-tripeptide-3 amide; andiroba oil; and a lipid mimetic in certain amounts increase proteins associated with cellular proliferation in wound healing.

[0008] In accordance with an aspect of the invention, provided is a skin care composition comprising palmitoyl sh-tripeptide-3 amide; a hyaluronic acid and/or a salt thereof; a lipid mimetic; and an amino acid system.

[0009] In accordance with another aspect of the invention, provided is a skin care composition including palmitoyl sh-tripeptide-3 amide; an acetylated hyaluronic acid and/or a salt thereof; a lipid mimetic; an amino acid system; and from about 60 to about 90 wt.% of water, wherein all weight percentages are based on the total weight of the skin care composition. [0010] In accordance with a further aspect of the invention, provided is a skin care composition including palmitoyl sh-tripeptide-3 amide; andiroba oil; a lipid mimetic; and from about 60 to about 90 wt.% of water, wherein all weight percentages are based on the total weight of the skin care composition.

[0011] A list of non-limiting embodiments according to aspects of the invention is provided below: [0012] In accordance with an embodiment 1, provided is a skin care composition comprising: palmitoyl sh-tripeptide-3 amide; a hyaluronic acid and/or a salt thereof; a lipid mimetic; and an amino acid system.

[0013] In accordance with an embodiment 2, provided is the skin care composition according to embodiment 1, wherein the palmitoyl sh-tripeptide-3 amide is present in an amount from about 0.005 to about 1 wt.%, based on the total weight of the skin care composition.

[0014] In accordance with an embodiment 3, provided is the skin care composition according to embodiment 1 or embodiment 2, wherein the hyaluronic acid and/or the salt thereof is present in an amount from about 0.1 to about 1.5 wt.%, based on the total weight of the skin care composition. [0015] In accordance with an embodiment 4, provided is the skin care composition according to any foregoing embodiment, wherein the hyaluronic acid and/or the salt thereof is selected from an acetylated hyaluronic acid and/or a salt thereof.

[0016] In accordance with an embodiment 5, provided is the skin care composition according to any foregoing embodiment, wherein the lipid mimetic comprises one or more of jojoba oil/macadamia seed oil ester, squalene, phytosterylmacadamiate, or phytosterol.

[0017] In accordance with an embodiment 6, provided is the skin care composition according to any foregoing embodiment, wherein the lipid mimetic comprises jojoba oil/macadamia seed oil ester, squalene, and phytosterylmacadamiate.

[0018] In accordance with an embodiment 7, provided is the skin care composition according to embodiment 5 or embodiment 6, wherein the jojoba oil/macadamia seed oil esters and squalene are present in the skin care composition in a weight ratio of about 1 :2 to about 1:15.

[0019] In accordance with an embodiment 8, provided is the skin care composition according to any foregoing embodiment, wherein the lipid mimetic is present in an amount from about 1 to about 9 wt.%, based on the total weight of the skin care composition. [0020] In accordance with an embodiment 9, provided is the skin care composition according to any foregoing embodiment, wherein the amino acid system is present in an amount from about 1 to about 5 wt.%, based on the total weight of the skin care composition.

[0021] In accordance with an embodiment 10, provided is the skin care composition according to any foregoing embodiment, wherein the amino acid system comprises two or more amino acids selected from the group consisting of arginine, lysine, serine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, alanine, aminobutyrate, asparagine, cysteine, cystine, glutamine, glycine, hydroxyproline, isoleucine, leucine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, valine, and a combination of two or more thereof.

[0022] In accordance with an embodiment 11, provided is the skin care composition according to any foregoing embodiment, wherein the amino acid system comprises two or more of arginine, lysine, glycine, taurine, or tyrosine.

[0023] In accordance with an embodiment 12, provided is the skin care composition according to any foregoing embodiment, wherein the amino acid system comprises arginine, glycine, and taurine.

[0024] In accordance with an embodiment 13, provided is the skin care composition according to any foregoing embodiment further comprising: a fatty alcohol, optionally, present in an amount from about 1 to about 9 wt.%, based on the total weight of the skin care composition.

[0025] In accordance with an embodiment 14, provided is the skin care composition according to embodiment 13, wherein the fatty alcohol comprises octyl dodecanol.

[0026] In accordance with an embodiment 15, provided is the skin care composition according to any foregoing embodiment further comprising: a polyol, optionally, present in an amount from about 2 to about 15 wt.%, based on the total weight of the skin care composition.

[0027] In accordance with an embodiment 16, provided is the skin care composition according to embodiment 15, wherein the polyol is selected from ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, glycerin, diglycerin, diethylene glycol, dipropylene glycol, sorbitol, pentylene glycol, caprylyl glycol, 1,2-hexanediol, 1,2-pentanediol, and a combination of two or more thereof. [0028] In accordance with an embodiment 17, provided is the skin care composition according to any foregoing embodiment further comprising: from about 60 to about 90 wt.% of water, based on the total weight of the skin care composition.

[0029] In accordance with an embodiment 18, provided is a skin care composition comprising: palmitoyl sh-tripeptide-3 amide; an acetylated hyaluronic acid and/or a salt thereof; a lipid mimetic; an amino acid system; and from about 60 to about 90 wt.% of water, wherein all weight percentages are based on the total weight of the skin care composition.

[0030] In accordance with an embodiment 19, provided is the skin care composition according to any foregoing embodiment further comprising: andiroba oil.

[0031] In accordance with an embodiment 20, provided is the skin care composition according to embodiment 19, wherein the andiroba oil is present in an amount from about 0.1 to about 5 wt.%. [0032] In accordance with an embodiment 21, provided is the skin care composition according to any one of embodiment 18 to embodiment 20, wherein the lipid mimetic comprises one or more of jojoba oil/macadamia seed oil ester, squalene, phytosterylmacadamiate, or phytosterol.

[0033] In accordance with an embodiment 22, provided is the skin care composition according to any one of embodiment 18 to embodiment 21, wherein the lipid mimetic comprises jojoba oil/macadamia seed oil ester, squalene, and phytosterylmacadamiate.

[0034] In accordance with an embodiment 23, provided is the skin care composition according to embodiment 21 or embodiment 22, wherein the jojoba oil/macadamia seed oil esters and squalene are present in the skin care composition in a weight ratio of about 1 :2 to about 1:15.

[0035] In accordance with an embodiment 24, provided is the skin care composition according to one of embodiment 18 to embodiment 23, wherein the lipid mimetic is present in an amount from about 1 to about 9 wt.%.

[0036] In accordance with an embodiment 25, provided is a skin care composition comprising: palmitoyl sh-tripeptide-3 amide; a lipid mimetic; from about 0.1 to about 10 wt.% of a hydrophobic component, the hydrophobic component comprising andiroba oil; and from about 60 to about 90 wt.% of water, wherein all weight percentages are based on the total weight of the skin care composition.

[0037] In accordance with an embodiment 26, provided is the skin care composition according to embodiment 25 further comprising: an amino acid system present in an amount from about 1 to about 5 wt.%. [0038] In accordance with an embodiment 27, provided is the skin care composition according to embodiment 25 or embodiment 26, wherein the amino acid system comprises two or more amino acids selected from the group consisting of arginine, lysine, serine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, alanine, aminobutyrate, asparagine, cysteine, cystine, glutamine, glycine, hydroxyproline, isoleucine, leucine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, valine, and a combination of two or more thereof.

[0039] In accordance with an embodiment 28, provided is the skin care composition according to any one of embodiment 25 to embodiment 27, wherein the amino acid system comprises two or more of arginine, lysine, glycine, taurine, or tyrosine.

[0040] In accordance with an embodiment 29, provided is the skin care composition according to any one of embodiment 25 to embodiment 28, wherein the amino acid system comprises arginine, glycine, and taurine.

[0041 ] In accordance with an embodiment 30, provided is the skin care composition according to any one of embodiment 25 to embodiment 29, wherein the hydrophobic component further comprises octyldodecanol.

BRIEF DESCRIPTION OF THE DRAWINGS

[0042] The features, and advantages of the invention will be apparent from the following more detailed description of certain embodiments of the invention and as illustrated in the accompanying drawings in which:

[0043] FIG. 1 provides images of skin explants after application of water, a comparative composition, or a non-limiting example composition according to aspects of the invention; and [0044] FIG. 2 is a bar graph showing the wound recovery of skin explants after application with water, a comparative composition, or a non-limiting example composition according to aspects of the invention.

[0045] It should be understood that the various aspects are not limited to the compositions, arrangements, and instrumentality shown in the figures. DETAILED DESCRIPTION

[0046] For illustrative purposes, the principles of the present invention are described by referencing various exemplary embodiments thereof. Although certain embodiments of the invention are specifically described herein, one of ordinary skill in the art will readily recognize that the same principles are equally applicable to, and can be employed in other apparatuses and methods. Before explaining the disclosed embodiments of the present invention in detail, it is to be understood that the invention is not limited in its application to the details of any particular embodiment shown. The terminology used herein is for the purpose of description and not of limitation.

[0047] As used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural references unless the context dictates otherwise. The singular form of any class of the ingredients refers not only to one chemical species within that class, but also to a mixture of those chemical species. The terms “a” (or “an”), “one or more” and “at least one” may be used interchangeably herein. The terms “comprising”, “including”, and “having” may be used interchangeably. The term “include” should be interpreted as “include, but are not limited to”. The term “including” should be interpreted as “including, but are not limited to”.

[0048] As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. Thus, a range from 1-5, includes specifically 1, 2, 3, 4 and 5, as well as subranges such as 2-5, 3-5, 2-3, 2-4, 1-4, etc.

[0049] The term “about” when referring to a number means any number within a range of 10% of the number. For example, the phrase “about 2 wt.%” refers to a number between and including 1.8 wt.% and 2.2 wt.%.

[0050] All references cited herein are hereby incorporated by reference in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.

[0051] The abbreviations and symbols as used herein, unless indicated otherwise, take their ordinary meaning. The abbreviation “wt.%” means percent by weight with respect to the skin care composition. The symbol “°” refers to a degree, such as a temperature degree or a degree of an angle. The symbols “h”, “min”, “mb”, “nm”, and “pm” refer to hour, minute, milliliter, nanometer, and micrometer, respectively. The abbreviation “UV-VIS” referring to a spectrometer or spectroscopy, means Ultraviolet- Visible. The abbreviation “rpm” means revolutions per minute.

[0052] When referring to chemical structures, and names, the symbols “C”, “H”, and “O” mean carbon, hydrogen, and oxygen, respectively. The symbols “=” and “= ’ mean single bond, double bond, and triple bond, respectively.

[0053] “Volatile”, as used herein, means having a flash point of less than about 100° C. “Nonvolatile”, as used herein, means having a flash point of greater than about 100° C.

[0054] “Cosmetically acceptable” means that the item in question is compatible with a keratinous substrate, such as skin. For example, a “cosmetically acceptable carrier” means a carrier that is compatible with a keratinous substrate, such as skin.

[0055] Any member in a list of species that are used to exemplify or define a genus, may be mutually different from, or overlapping with, or a subset of, or equivalent to, or nearly the same as, or identical to, any other member of the list of species. Further, unless explicitly stated, such as when reciting a Markush group, the list of species that define or exemplify the genus is open, and it is given that other species may exist that define or exemplify the genus just as well as, or better than, any other species listed.

[0056] The phrases, “a mixture thereof,” “a combination thereof,” or a combination of two or more thereof’ do not require that the mixture include all of A, B, C, D, E, and F (although all of A, B,

C, D, E, and F may be included). Rather, it indicates that a mixture of any two or more of A, B, C,

D, E, and F can be included. In other words, it is equivalent to the phrase “one or more elements selected from the group consisting of A, B, C, D, E, F, and a mixture of any two or more of A, B, C, D, E, and F ” Likewise, the term “a salt thereof’ also relates to “salts thereof.” Thus, where the disclosure refers to “an element selected from the group consisting of A, B, C, D, E, F, a salt thereof, and a mixture thereof,” it indicates that that one or more of A, B, C, D, and F may be included, one or more of a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included, or a mixture of any two of A, B, C, D, E, F, a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included.

[0057] All components and elements positively set forth in this disclosure can be negatively excluded from the claims. In other words, the skin care compositions of the instant disclosure can be free or essentially free of all components and elements positively recited throughout the instant disclosure. In some instances, the skin care compositions of the present disclosure may be substantially free of non-incidental amounts of the ingredient(s) or compound(s) described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound that is added into the skin care composition by itself. For example, a skin care composition may be substantially free of a non-incidental amount of an ingredient or compound, although such ingredient(s) or compound(s) may be present as part of a raw material that is included as a blend of two or more compounds.

[0058] Some of the various categories of components identified may overlap. In such cases where overlap may exist and the skin care composition includes both components (or the composition includes more than two components that overlap), an overlapping compound does not represent more than one component. For example, certain compounds may be characterized as both an emollient and a wax. If a particular skin care composition includes both an emollient and a wax, a compound that may be characterized as both an emollient and a wax will serve only as either an emollient or a wax — not both.

[0059] For readability purposes, the chemical functional groups are in their adjective form; for each of the adjectives, the word “group” is assumed. For example, the adjective “alkyl” without a noun thereafter, should be read as “an alkyl group”.

[0060] The present disclosure relates skin care compositions adapted to improve the appearance and/or health of skin. For example, the inventors discovered that skin care compositions containing certain combinations of palmitoyl sh-tripeptide-3 amide, a hyaluronic acid and/or a salt thereof, a lipid mimetic, and an amino acid system can achieve enhanced wound healing. Additionally, it was unexpectedly discovered that skin care compositions comprising specific combinations of palmitoyl sh-tripeptide-3 amide; andiroba oil; and a lipid mimetic in certain amounts increase proteins associated with cellular proliferation in wound healing.

[0061] In accordance with an aspect of the invention, provided is a skin care composition comprising palmitoyl sh-tripeptide-3 amide; a hyaluronic acid and/or a salt thereof; a lipid mimetic; and an amino acid system.

[0062] In accordance with another aspect of the invention, provided is a skin care composition including palmitoyl sh-tripeptide-3 amide; an acetylated hyaluronic acid and/or a salt thereof; a lipid mimetic; an amino acid system; and from about 60 to about 90 wt.% of water, wherein all weight percentages are based on the total weight of the skin care composition. [0063] In accordance with a further aspect of the invention, provided is a skin care composition including palmitoyl sh-tripeptide-3 amide; an andiroba oil; a lipid mimetic; and from about 60 to about 90 wt.% of water, wherein all weight percentages are based on the total weight of the skin care composition.

[0064] The skin care compositions may be formulated to be translucent and/or transparent. Translucent, as used herein, refers to the characteristic of a skin care composition to permit the passage of light but does not necessarily allow for detailed objects to be distinguished through a thickness of 1 cm of the skin care composition. The term “transparent” with respect to skin care compositions of the present disclosure indicates that the skin care composition has transmittance of visible light of at least 65%, for example measured using a Lambda 40 UV-visible or Lambda 25 UV-visible spectrometer. The skin care compositions may have, for example, a transmittance of at least 70%, at least 75%, at least 80%, at least 85%, at least 88%, at least 90%, or at least 95% at a wavelength of 600 nm, measured, for example, using a Lambda 40 UV-visible spectrometer or Lambda 25 UV-visible spectrometer.

[0065] Suitable components, such as those listed below, may be included or excluded from the formulations for the skin care compositions depending on the specific combination of other components, the form of the skin care compositions, and/or the use of the formulation (e.g., a serum, lotion, cream, etc.). The skin care composition may comprise a single phase with all the ingredients and components contained therein. In other embodiments, the skin care composition may include two or more phases, such as a hydrophilic phase and a hydrophobic phase. For example, the skin care composition may include two or more phases and be in the form of an oil- in-water emulsion, a water-in-oil emulsion, or a two-phase composition having a first phase, a second, phase, and a single interphase therebetween. In at least one embodiment, the skin care composition is in the form of a serum. In other embodiments, the skin care composition is in the form of a lotion or a cream.

[0066] The skin care composition typically comprises palmitoyl sh-tripeptide-3 amide. The amount of palmitoyl sh-tripeptide-3 amide present in the skin care composition may be from about 0.005 to about 1 wt.%, based on the total weight of the skin care composition. For example, the amount of palmitoyl sh-tripeptide-3 amide in the skin care composition may be from about 0.005 to about 0.8 wt.%, about 0.005 to about 0.6 wt.%, about 0.005 to about 0.4 wt.%, about 0.005 to about 0.2 wt.%, about 0.005 to about 0.1 wt.%, about 0.005 to about 0.05 wt.%, about 0.005 to about 0.01 wt.%; from about 0.01 to about 1 wt.%, about 0.01 to about 0.8 wt.%, about 0.01 to about 0.6 wt.%, about 0.01 to about 0.4 wt.%, about 0.01 to about 0.2 wt.%, about 0.01 to about 0.1 wt.%, about 0.01 to about 0.05 wt.%; from about 0.05 to about 1 wt.%, about 0.05 to about 0.8 wt.%, about 0.05 to about 0.6 wt.%, about 0.05 to about 0.4 wt.%, about 0.05 to about 0.2 wt.%, about 0.05 to about 0.1 wt.%; from about 0.1 to about 1 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.8 wt.%, about 0.1 to about 0.6 wt.%, about 0.1 to about 0.4 wt.%, about 0.1 to about 0.2 wt.%; from about 0.2 to about 1 wt.%, about 0.2 to about 0.8 wt.%, about 0.2 to about 0.6 wt.%, about 0.2 to about 0.4 wt.%; from about 0.4 to about 1 wt.%, about 0.4 to about 0.8 wt.%, about 0.4 to about 0.6 wt.%, about 0.6 to about 1 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0067] In addition to the palmitoyl sh-tripeptide-3 amide, the skin care compositions may include a hyaluronic acid and/or a salt thereof. The amount of hyaluronic acid and/or a salt thereof present in the skin care composition may be about 0.1 to about 1.7 wt.%, based on the total weight of the skin care composition. In some embodiments, the amount of hyaluronic acid and/or a salt thereof present in the skin care composition is from about 0.1 to about 1.4 wt.%, about 0.1 to about 1.1 wt.%, about 0.1 to about 0.9 wt.%, about 0.1 to about 0.7 wt.%; from about 0.4 to about 1.7 wt.%, about 0.4 to about 1.4 wt.%, about 0.4 to about 1.1 wt.%, about 0.4 to about 0.9 wt.%; from about 0.7 to about 1.7 wt.%, about 0.7 to about 1.4 wt.%, about 0.7 to about 1.1 wt.%; from about 1 to about 1.7 wt.%, about 1 to about 1.4 wt.%, about 1.3 to about 1.7 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0068] The hyaluronic acid and/or a salt thereof may be acetylated. For instance, the skin care composition may have hyaluronic acid(s) and/or salt(s) thereof that are selected from acetylated hyaluronic acids and/or salts thereof.

[0069] The hyaluronic acid and/or a salt thereof may have an average molecular weight of about 10,000 to 400,000 Da. In some embodiments, the hyaluronic acid(s) and/or salt(s) thereof has/have a molecular weight of about 10,000 to about 300,000 Da, about 10,000 to about 200,000 Da, about 10,000 to about 100,000 Da, about 10,000 to about 80,000 Da, about 10,000 to about 60,000 Da, about 10,000 to about 50,000 Da, about 10,000 to about 40,000 Da; from about 50,000 to about 300,000 Da, about 50,000 to about 200,000 Da, about 50,000 to about 100,000 Da, about 50,000 to about 80,000 Da, about 50,000 to about 60,000 Da; from about 100,000 to about 300,000 Da, about 100,000 to about 200,000 Da, about 100,000 to about 150,000 Da; from about 200,000 to about 300,000 Da, about 200,000 to about 250,000 Da, or any range or subrange thereof.

[0070] In certain preferred embodiments, the hyaluronic acid(s) and/or salt(s) thereof have an average molecular weight of about 10,000 to about 50,000 Da, about 10,000 to about 40,000 Da, about 10,000 to about 30,000 Da; from about 15,000 to about 50,000 Da, about 15,000 to about 40,000 Da, about 15,000 to about 30,000 Da; from about 20,000 to about 50,000 Da, about 20,000 to about 40,000 Da, about 20,000 to about 30,000 Da; from about 25,000 to about 50,000 Da, about 25,000 to about 40,000 Da, or any range or subrange thereof. Without being limited to any particular theory, it may be particularly preferable to include acetylated hyaluronic acid(s) and/or salt(s) thereof having an average molecular weight of about 10,000 to about 50,000 Da, about 10,000 to about 40,000 Da, about 10,000 to about 30,000 Da; from about 15,000 to about 50,000 Da, about 15,000 to about 40,000 Da, about 15,000 to about 30,000 Da; from about 20,000 to about 50,000 Da, about 20,000 to about 40,000 Da, about 20,000 to about 30,000 Da; from about 25,000 to about 50,000 Da, about 25,000 to about 40,000 Da, or any range or subrange thereof. [0071] The skin care composition typically comprises a lipid mimetic (also referred to as a lipid mimetic component). The lipid mimetic may comprise one or more of jojoba oil/macadamia seed oil esters, squalene, phytosterylmacadamiate, and/or phytosterols. In some embodiments, the lipid mimetic may comprise jojoba oil/macadamia seed oil esters and squalene. In further embodiments, the lipid mimetic may comprise jojoba oil/macadamia seed oil esters, squalene, phytosterylmacadamiate, and phytosterols (e.g., phytosteryl macadamiate). The lipid mimetic may consist of jojoba oil/macadamia seed oil esters, squalene, phytosterylmacadamiate, a phytosterol, and combinations of two or more thereof in certain instances. The jojoba oil/macadamia seed oil esters and squalene may be present in the skin care composition in a weight ratio of the jojoba oil/macadamia seed oil esters to the squalene of about 1 : 1 to about 1 to 15. In some embodiments, the jojoba oil/macadamia seed oil esters and squalene may be present in the skin care composition in a weight ratio of the jojoba oil/macadamia seed oil esters to the squalene of about 1 :2 to about 1 : 15, about 1:4 to about 1 : 15, about 1 :6 to about 1 :15, about l :8 to about 1 : 15, about l : 10 to about 1 : 15; from about 1:2 to about 1 : 12, about 1:4 to about 1 :12, about 1 :6 to about 1 : 12, about 1 :8 to about 1 : 12; from about 1 :2 to about 1 : 10, about 1:4 to about 1: 10, about 1 :6 to about 1 :10, about 1 :8 to about 1 : 10, or any range or subrange thereof. In at least one embodiment, the jojoba oil/macadamia seed oil esters and squalene are present in the skin care composition in a weight ratio of the jojoba oil/macadamia seed oil esters to the squalene of about 1 :7.

[0072] The lipid mimetic (also referred to as a lipid mimetic component) may be present in an amount from about 1 to about 9 wt.%, based on the total weight of the skin care composition. For instance, the total amount of the lipid mimetic may be from about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 9 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 4 to about 9 wt.%, about 4 to about 8 wt.%, about 4 to about 6 wt.%; from about 6 to about 9 wt.%, about 6 to about 8 wt.%, or any range or subrange thereof, based on the total weight skin care composition.

[0073] The skin care compositions include an amino acid system in an amount that may vary, but typically is in a range from about 0.1 to about 8 wt.%, based on the total weight of the skin care composition. For instance, the total amount of the amino acid system in the skin care composition may be from about 0.1 to about 6 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.5 to about 8 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 1.4 to about 8 wt.%, about 1.4 to about 6 wt.%, about 1.4 to about 4 wt.%, about 1.4 to about 3 wt.%, about 1.4 to about 2.3 wt.%; from about 1.8 to about 8 wt.%, about 1.8 to about 6 wt.%, about 1.8 to about 4 wt.%, about 1.8 to about 3 wt.%, about 1.8 to about 2.6 wt.%; from about 2.1 to about 8 wt.%, about 2.1 to about 6 wt.%, about 2.1 to about 4 wt.%, about 2.1 to about 3 wt.%; from about 2.4 to about 8 wt.%, about 2.4 to about 6 wt.%, about 2.4 to about 4 wt.%, about 2.4 to about 3 wt.%; from about 2.7 to about 8 wt.%, about 2.7 to about 6 wt.%, about 2.7 to about 4 wt.%, about 2.7 to about 3.5 wt.%; from about 3 to about 8 wt.%, about 3 to about 6 wt.%, about 3 to about 4 wt.%; from about 3.3 to about 8 wt.%, about 3.3 to about 6 wt.%, about 3.3 to about 4 wt.%; from about 3.6 to about 8 wt.%, about 3.6 to about 6 wt.%, about 3.6 to about 5 wt.%, about 3.6 to about 4.5 wt.%; from about 4 to about 8 wt.%, about 4 to about 6 wt.%, about 4 to about 5 wt.%; from about 4.5 to about 8 wt.%, about 4.5 to about 6 wt.%, about 4.5 to about 5.5 wt.%; from about 5 to about 8 wt.%, about 5 to about 7 wt.%, about 5 to about 6 wt.%; from about 5.5 to about 8 wt.%, about 5.5 to about 7 wt.%, about 5.5 to about 6.5 wt.%; from about 6 to about 8 wt.%, about 6 to about 7 wt.%, about 5 to about 6 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0074] The amino acid system may comprise two or more, three or more, four or more, five or more, six or more, seven or more, or eight or more amino acids. In at least one embodiment, the amino acid system is formed of two, three, four, five, six, or any range or subrange therebetween, of amino acids. The amino acid system may comprise an amino acid chosen from arginine, lysine, serine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, alanine, aminobutyrate, asparagine, cysteine, cystine, glutamine, glycine, hydroxyproline, isoleucine, leucine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, valine, or a combination of two or more thereof. In some cases, the amino acid system includes one or more amino acid selected from taurine, arginine, glycine, serine, lysine, and/or a combination of two or more thereof. For instance, the amino acid system may comprise two or more of arginine, lysine, glycine, taurine, or tyrosine. The amino acid system may have amino acids selected form the group consisting of arginine, lysine, serine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, alanine, aminobutyrate, asparagine, cysteine, cystine, glutamine, glycine, hydroxyproline, isoleucine, leucine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, valine, and a combination of two or more thereof

[0075] Preferably, the amino acid system comprises one or more amino acid chosen from taurine, arginine, and glycine. The amino acid system may comprise taurine, arginine, and glycine. In at least one embodiment, the amino acid system consists of taurine, arginine, and glycine.

[0076] The amino acid system may be specifically formulated to have a weight ratio of arginine to taurine of about 2: 1 to about 1:6. For instance, the amino acid system may have a weight ratio of the arginine to the taurine of about 2: 1 to about 1 :5, about 2: 1 to about 1 :4, about 2: 1 to about 1 :3, about 2: 1 to about 1 :2; from about 1 : 1 to about 1 :6, about 1 : 1 to about 1 :5, about 1 : 1 to about 1 :4, about 1 : 1 to about 1:3, about 1 : 1 to about 1 :2; from about 1 :1.5 to about 1:6, about 1 :1.5 to about 1 :5, about 1 : 1.5 to about 1:4, about 1 : 1.5 to about 1 :3, about 1 : 1.5 to about 1:2; from about 1 :2 to about 1 :6, about 1 :2 to about 1 :5, about 1 :2 to about 1 :4, about 1:2 to about 1 :3, about 1 :2 to about 1 :2.5; from about 1 :2.5 to about 1 :6, about 1 :2.5 to about 1 :5, about 1 :2.5 to about 1 :4, about 1 :2.5 to about 1 :3, or any range or subrange thereof. [0077] Additionally or alternatively, the skin care composition may have an amino acid system comprising arginine and glycine in a weight ratio of the arginine to the glycine of about 22:1 to about 48: 1. For example, the amino acid system may have a weight ratio of the arginine to the glycine of about 22: 1 to about 48: 1, about 22: 1 to about 44: 1, about 22: 1 to about 40: 1, about 22: 1 to about 37: 1, about 22: 1 to about 34: 1; from about 26: 1 to about 48: 1, about 26: 1 to about 44: 1, about 26: 1 to about 40: 1, about 26: 1 to about 37:1, about 26: 1 to about 34: 1; from about 30:1 to about 48:1, about 30: 1 to about 44: 1, about 30: 1 to about 40: 1, about 30: 1 to about 37: 1, about 30: 1 to about 34: 1; from about 33: 1 to about 48: 1, about 33: 1 to about 44: 1, about 33: 1 to about 40: 1, about 33:1 to about 37: 1, about 33: 1 to about 35: 1; from about 37: 1 to about 48:1, about 37: 1 to about 44: 1, about 37: 1 to about 40: 1, or any range or subrange thereof.

[0078] In certain embodiments, the amino acid system may comprise or consist of a glycine in an amount from about 0.01 to about 0.8 wt.%; an arginine from about 0.2 to about 3 wt.%; and a taurine in an amount from about 1 to about 4 wt.%, wherein the weight percentages are based on the total weight of the skin care composition. The glycine may be present in certain cases in an amount from about 0.01 to about 0.8 wt.%, about 0.01 to about 0.6 wt.%, about 0.01 to about 0.4 wt.%, about 0.01 to about 0.2 wt.%, about 0.01 to about 0.1 wt.%, about 0.01 to about 0.05 wt.%; from about 0.1 to about 0.8 wt.%, about 0.1 to about 0.6 wt.%, about 0.1 to about 0.4 wt.%, about 0.1 to about 0.2 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition. Additionally or alternatively, the amount arginine in the skin care composition may be from about 0.2 to about 2.5 wt.%, about 0.2 to about 2 wt.%, about 0.2 to about 1.7 wt.%, about 0.2 to about 1.2 wt.%, about 0.2 to about 1 wt.%; from about 0.5 to about 3 wt.%; about 0.5 to about 2.5 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1.7 wt.%, about 0.5 to about 1.2 wt.%, about 0.5 to about 1 wt.%; from about 0.8 to about 3 wt.%; about 0.8 to about 2.5 wt.%, about 0.8 to about 2 wt.%, about 0.8 to about 1.7 wt.%, about 0.8 to about 1.2 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition. The amount of taurine in the skin care composition may, also or alternatively, be from about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2.5 wt.%, about 1 to about 2.2 wt.%; from about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2.5 wt.%, about 1.5 to about 2.2 wt.%; from about 1.9 to about 4 wt.%, about 1.9 to about 3 wt.%, about 1.9 to about 2.5 wt.%, about 1.9 to about 2.2 wt.%; or any range or subrange thereof, based on the total weight of the skin care composition. In at least one embodiment, the amino acid system may comprise or consist of a glycine in an amount from about 0.01 to about 0.05 wt.%; an arginine from about 0.8 to about 1.2 wt.%; and a taurine in an amount from about 1.9 to about 2.2 wt.%, wherein the weight percentages are based on the total weight of the skin care composition.

[0079] In certain preferred embodiments, the skin care composition includes an andiroba oil. The amount of andiroba oil present in the skin care composition may from about 0. 1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%, about 0.1 to about 0.1 wt.%; about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; about 0.75 to about 5 wt.%, about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%, about 0.75 to about 1 wt.%; about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; about 3 to about 5 wt.%, about 3 to about 4 wt.%, including any range or subrange therebetween, based on the total weight of the skin care composition.

[0080] The skin care composition may include one or more polyol(s) in an amount that may vary depending on the form of the skin care composition and/or other components therein. The amount of polyols in the skin care composition may be from about 1 to about 20%, based on the total weight of the skin care composition. For example, the amount of polyol present in the skin care compositions may be from about 1 to about 20 wt.%, about 1 to about 15 wt.%, about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%; from about 2 to about 20 wt.%, about 2 to about 15 wt.%, about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 4 wt.%; from about 4 to about 20 wt.%, about 4 to about 15 wt.%, about 4 to about 10 wt.%, about 4 to about 8 wt.%; from about 6 to about 20 wt.%, about 6 to about 15 wt.%, about 6 to about 10 wt.%, about 6 to about 8 wt.%; from about 9 to about 20 wt.%, about 9 to about 15 wt.%, about 9 to about 12 wt.%, from about 12 to about 20 wt.%, about 18 to about 15 wt.%, about 12 to about 15 wt.%, including ranges and subranges thereof, based on the total weight of the skin care composition.

[0081] The polyol(s) may be chosen from glycols or compounds with numerous hydroxyl groups. The term “polyol” should be understood as meaning, within the meaning of the present disclosure, an organic molecule comprising at least two free hydroxyl groups. The polyols of the skin care composition may be glycols or compounds with numerous hydroxyl groups. In some cases, the one or more polyols is/are selected from the group consisting of C2-C32 polyols. The one or more polyols may have from 2 to 32 carbon atoms, from 3 to 16 carbon atoms, or from 3 to 12 carbon atoms.

[0082] Polyols that may be included in the skin care composition, in certain instances, include ethylene glycol, propylene glycol, butylene glycol, caprylyl glycol hexylene glycol, glycerin, diglycerin, diethylene glycol, and dipropylene glycol, and mixtures thereof. In some cases, the polyol is propylene glycol and/or caprylyl glycol. In some further cases, the skin care composition comprises at least propylene glycol, and optionally one or more polyols other than propylene glycol.

[0083] Non-limiting examples of polyols that may, optionally, be included in the skin care composition include and/or may be chosen from alkanediols such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2 -butene- 1,4-diol, 2-ethyl-l,3-hexanediol, 2-methyl-2,4-pentanediol, caprylyl glycol, 1,2-hexanediol, 1,2-pentanediol, and 4-methyl-l ,2-pentanediol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol mono-iso-propyl ether, diethylene glycol mono-iso-propyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-t-butyl ether, diethylene glycol mono-t-butyl ether, 1-methyl-l-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-t- butyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-iso-propyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether, dipropylene glycol mono-iso-propyl ether, sorbitol, sorbitan, triacetin, and a combination of two or more thereof.

[0084] The one or more polyols may, optionally, be glycols or glycol ethers such as, e.g., monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or ethers thereof such as, e.g., monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol as well as alkyl ethers of diethylene glycol, e.g., monoethyl ether or monobutyl ether of diethylene glycol. In some cases, the one or more polyols may include or are chosen from ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, pentylene glycol, 1,3- propanediol, diethylene glycol, dipropylene glycol, 1,4-butanediol, 1,5-pentanediol, hexane-1,6- diol, glycerin, diglycerin, caprylyl glycol, and a mixture thereof. Non-limiting examples of polyols that may be included in the skin care composition, in certain instances, include ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, diglycerin, diethylene glycol, and dipropylene glycol, and a combination of two or more thereof.

[0085] The skin care composition may include one or more polyol(s) that are humectants. Examples of humectants that may be incorporated in certain embodiments include triethylene glycol, tripropylene glycol, propylene glycol, caprylyl glycol, glycerin, polyethylene glycols, polypropylene glycol, glycerin, sorbitol, hexylene glycol, butylene glycol, hyaluronic acid, 1,2 hexanediol, saccharide isomerate and a combination of two or more thereof. In some cases, the one or more humectants comprise at least one of glycerin, caprylyl glycol, propylene glycol, or polyethylene glycol and, optionally, one or more additional humectants.

[0086] The skin care composition typically includes one or more thickening agent(s). The total amount of thickening agent(s) in the skin care composition may be from about 0.1 to about 7 wt.%, based on the total weight of the skin care composition. In some instances, the total amount of thickening agent(s) present in skin care composition is about 0.1 to about 6 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.4 to about 7 wt.%, about 0.4 to about 6 wt.%, about 0.4 to about 5 wt.%, about 0.4 to about 4 wt.%, about 0.4 to about 3 wt.%, about 0.4 to about 2 wt.%, about 0.4 to about 1 wt.%; from about 0.8 to about 7 wt.%, about 0.8 to about 6 wt.%, about 0.8 to about 5 wt.%, about 0.8 to about 4 wt.%, about 0.8 to about 3 wt.%, about 0.8 to about 2 wt.%; from about 1.4 to about 7 wt.%, about 1.4 to about 6 wt.%, about 1.4 to about 5 wt.%, about 1.4 to about 4 wt.%, about 1.4 to about 3 wt.%; from about 2 to about 7 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 3 to about 7 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%; from about 4 to about 7 wt.%, about 4 to about 6 wt.%, about 5 to about 7 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0087] Thickening agents are typically included to increase the viscosity of the skin care compositions. Nonetheless, in some instances, certain thickening agents provide additional, surprising benefits to the skin care compositions.

[0088] The one or more thickening agent(s) may be selected from natural gums, polyacrylate crosspolymers or crosslinked polyacrylate polymers, cationic acrylate copolymers, anionic acrylic or carboxylic acid polymers, polyacrylamide polymers, polysaccharides such as cellulose derivatives, cationic gums, and a combination of two or more thereof. Examples of polysaccharides include cellulose, carboxymethyl hydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof.

[0089] Non-limiting examples of these natural gums include acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof. Examples of polyacrylates include methyl acrylate, ethyl acrylate, and butyl acrylate as well as C10-30 alkyl acrylate crosspolymer.

[0090] The thickening agents may comprise 1 -propanesulfonic acid, 2-methyl-2-[(l-oxo-2- propenyl)amino]-, monosodium salt, homopolymer. In some preferred embodiments, the thickening agents may comprise cellulose and 1 -propanesulfonic acid, 2-methyl-2-[(l-oxo-2- propenyl)amino]-, monosodium salt, homopolymer.

[0091] The skin care composition may comprise a hydrophobic component in an amount that may, e.g., be from about 0.1 to about 10 wt.%, based on the total weight of the skin care composition. The total amount of the hydrophobic component present in the skin care composition may from about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; about 0.5 to about 10 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 4 wt.%; about 4 to about 10 wt.%, about 4 to about 8 wt.%, about 4 to about 6 wt.%; about 6 to about 10 wt.%, about 6 to about 8 wt.%, about 8 to about 10 wt.%, including ranges and subranges thereof, based on the total weight of the skin care composition. [0092] The hydrophobic component may comprise one or more fatty compound, such as those selected from fatty alcohols, fatty ethers, waxes, and/or oils (e g., silicone and hydrocarbon based oils). In some embodiments, the fatty compound(s) of the skin care composition consist of those selected from fatty alcohols, waxes, and oils. The hydrophobic component may be specifically adapted to consist of one or more of fatty alcohols, fatty ethers, waxes, and/or oils. For example, the hydrophobic component may consist of one or more fatty compounds selected from fatty alcohols, oils, waxes, and a combination of two or more thereof. In at least one embodiment, the hydrophobic component consists of one or more fatty compound selected from fatty alcohols, oils (e.g., hydrocarbon based oils), and a combination of two or more thereof.

[0093] Examples of additional fatty alcohols that are worth noting include certain saturated or an unsaturated fatty alcohols. The saturated liquid fatty alcohols may be branched and optionally contain in their structure at least one aromatic or non-aromatic ring. In some instances, however, the fatty alcohols are acyclic. Non-limiting examples of liquid saturated fatty alcohols include octyl dodecanol, isostearyl alcohol, and 2 -hexyl decanol.

[0094] Exemplary unsaturated liquid fatty alcohols generally include in their structure at least one double or triple bond. For example, the unsaturated fatty alcohol may include several double bonds (such as 2 or 3 double bonds), which may be conjugated or non-conjugated. The unsaturated fatty alcohols can be linear or branched and may be acyclic or include in their structure at least one aromatic or non-aromatic ring. Liquid unsaturated fatty alcohols may include or be selected from oleyl alcohol, linoleyl alcohol, linolenyl alcohol, and/or undecylenyl alcohol.

[0095] The oil may be a linear or branched hydrocarbon selected from volatile or non-volatile liquid paraffins and derivatives thereof, polydecenes, isohexadecane, isododecane, hydrogenated polyisobutene, a mixture of n-undecane (Cn) and of n-tridecane (C13), and a combination of two or more thereof. The oil may be selected from hydrocarbon oils and/or plant-based oils. For example, the oil may be selected from hydrocarbon oils, preferably squalene and/or a squalene. In some cases, the hydrocarbon oils consists of a squalene, a squalene, or a combination thereof.

[0096] In some cases, the oil is a plant-based oil. For example, the oil may be a plant-based oil selected from sunflower oil, corn oil, soybean oil, marrow oil, grapeseed oil, sesame seed oil, hazelnut oil, apricot oil, macadamia oil, araba oil, coriander oil, castor oil, avocado oil, jojoba oil, shea butter oil, or a combination of two or more thereof. In at least one preferred embodiment, the oil comprises or consists of squalene, a squalene, and/or andiroba oil. For example, the skin care composition may comprise squalene, a squalene, and andiroba oil.

[0097] The wax(es) may be selected from those having one or more alkyl chain comprising 6 to 17 carbons, e.g., from 8 to 17, 10 to 17, 12 to 17, 13 to 17; from 8 to 15, 10 to 15, 12 to 15, 13 to 15; from 8 to 13, 10 to 13, or any range or subrange thereof. Examples of waxes that may be included in the skin care composition include tridodecanoyl glycerol, myristyl myristate, stearyl heptanoate, stearyl caprylate, tricaprin, cetearyl nonanoate, or a combination of two or more thereof. Preferably, the wax comprises or, in some cases, consists of tridodecanoyl glycerol. The wax may be selected from waxes having a melting point of about 30 to about 40 °C, e.g., from about 30 to about 38 °C, about 30 to about 35 °C, about 32 to about 40 °C, about 32 to about 38 °C, about 32 to about 35 °C, about 35 to about 40 °C, or about 35 to about 38 °C.

[0098] The skin care composition, in some embodiments, may have a hydrophobic component that is about 3 wt.% or less, based on the total weight of the skin care composition. In some embodiments, the skin care composition has about 2.5 wt.% or less, about 2 wt.% or less, 1 wt.% or less, 0.5 wt.% or less, 0.1 wt.% or less of fatty compounds and/or a hydrophobic component. In at least one embodiment, the skin care composition is substantially free of or free of fatty compounds and/or a hydrophobic component.

[0099] One or more emollient may be included in the skin care composition. Examples of emollients that may be included in the skin care composition include tridodecanoyl glycerol, squalane, cetearyl alcohol, dicetyl phosphate, ceteth-10 phosphate, ocytldodecanol, sunflower seed oil, a triglycieride (e.g., caprylic/capric triglyceride), or combinations thereof. For example, the skin care composition may include one or more emollient selected from tridodecanoyl glycerol, squalane, cetearyl alcohol, dicetyl phosphate, ceteth-10 phosphate, ocytldodecanol, and a combination of two or more thereof.

[0100] The amount of emollient present in the skin care composition may be from about 0.1 to about 7 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0. 1 to about 3 wt.%, about 0. 1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.4 to about 7 wt.%, about 0.4 to about 6 wt.%, about 0.4 to about 5 wt.%, about 0.4 to about 4 wt.%, about 0.4 to about 3 wt.%, about 0.4 to about 2 wt.%, about 0.4 to about 1 wt.%; from about 0.8 to about 7 wt.%, about 0.8 to about 6 wt.%, about 0.8 to about 5 wt.%, about 0.8 to about 4 wt.%, about 0.8 to about 3 wt.%, about 0.8 to about 2 wt.%; from about 1.4 to about 7 wt.%, about 1.4 to about 6 wt.%, about 1.4 to about 5 wt.%, about 1.4 to about 4 wt.%, about 1.4 to about 3 wt.%; from about 2 to about 7 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 3 to about 7 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%; from about 4 to about 7 wt.%, about 4 to about 6 wt.%, about 5 to about 7 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0101] The skin care composition may include one or more skin soothing agent(s), such as aloe vera extract, allantoin, licorice extract, glycyrrhizin, or combinations thereof. In some embodiments, the soothing agents may be selected from natural extracts comprising: centella asiatica extract, polygonum cuspidatum root extract, Scutellaria baicalensis root extract, camellia sinensis leaf extract, glycyrrhiza glabra (licorice) root extract, chamomilla recutita (matricaria) flower extract, rosmarinus officinalis (rosemary) leaf extract, tea (camellia sinensis) leaf extract, poria cocos extract, phragmites karka extract, lidocaine, chia seed extract, Rosa centifolia flower extract, aloe vera, allantoin, D-panthenol, turmeric, avocado oil, and lichen extract, or a combination of two or more thereof. One or more of the foregoing soothing agents may be excluded from the skin care composition in certain embodiments. In at least one embodiment, the skin care composition is free of allantoin and, optionally, one or more or all of the foregoing skin soothing agents.

[0102] The amount of the one or more skin soothing agent(s) in the skin care composition may be about 0.01 to about 7 wt.%, based on the total weight of the skin care composition. In some instances, the skin care composition may be formulated to have skin soothing agents(s) present in a total amount of about 0.01 to about 5 wt.%, about 0.01 to about 3 wt.%, about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.75 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.25 wt.%, about 0.01 to about 0.1 wt.%; from about 0.05 to about 7 wt.%, about 0.05 to about 5 wt.%, about 0.05 to about 3 wt.%, about 0.05 to about 2 wt.%, about 0.05 to about 1 wt.%, about 0.05 to about 0.75 wt.%, about 0.05 to about 0.5 wt.%, about 0.05 to about 0.25 wt.%, about 0.05 to about 0.1 wt.%; from about 0.1 to about 7 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.75 wt.%, about 0.1 to about 0.5 wt.%, about 0.1 to about 0.25 wt.%; from about 0.15 to about 7 wt.%, about 0.15 to about 5 wt.%, about 0.15 to about 3 wt.%, about 0.15 to about 2 wt.%, about 0.15 to about 1 wt.%, about 0.15 to about 0.75 wt.%, about 0.15 to about 0.5 wt.%, about 0.15 to about 0.25 wt.%; from about 0.4 to about 7 wt.%, about 0.4 to about 5 wt.%, about 0.4 to about 3 wt.%, about 0.4 to about 2 wt.%, about 0.4 to about 1 wt.%, about 0.4 to about 0.75 wt.%; from about 0.8 to about 7 wt.%, about 0.8 to about 5 wt.%, about 0.8 to about 3 wt.%, about 0.8 to about 2 wt.%, about 0.8 to about 1 wt.%; from about 1.2 to about 7 wt.%, about 1.2 to about 5 wt.%, about 1.2 to about 3 wt.%, about 1.2 to about 2 wt.%; from about 1.6 to about 7 wt.%, about 1.6 to about 5 wt.%, about 1.6 to about 3 wt.%, about 1.6 to about 2 wt.%; from about 2 to about 7 wt.%, about 2 to about 5 wt.%, about 2 to about 3 wt .%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0103] The skin care composition may comprise water in an amount from about 50 wt.% to about 90 wt.%, based on the total weight of the skin care composition. In some embodiments, the skin care composition has about 50 wt.% to about 90 wt.%, about 60 wt.% to about 90 wt.%, about 70 wt.% to about 90 wt.%, about 75 wt.% to about 90 wt.%, about 80 wt.% to about 90 wt.%, about 82 wt.% to about 90 wt.%, about 84 wt.% to about 90 wt.%; from about 50 wt.% to about 86 wt.%, about 60 wt.% to about 86 wt.%, about 70 wt.% to about 86 wt.%, about 75 wt.% to about 86 wt.%, about 80 wt.% to about 86 wt.%, about 82 wt.% to about 86 wt.%; from about 50 wt.% to about 83 wt.%, about 60 wt.% to about 83 wt.%, about 70 wt.% to about 83 wt.%, about 75 wt.% to about 83 wt.%, about 80 wt.% to about 83 wt.%; from about 50 wt.% to about 80 wt.%, about 60 wt.% to about 80 wt.%, about 70 wt.% to about 80 wt.%, about 75 wt.% to about 80 wt.%; from about 50 wt.% to about 75 wt.%, about 60 wt.% to about 75 wt.%, about 70 wt.% to about 75 wt.%; from about 50 wt.% to about 65 wt.%, about 60 wt.% to about 65 wt.%, or any range or subrange thereof, based on the total weight of the skin care composition.

[0104] The skin care composition of the invention may optionally include cooling agents (e.g., non-wax cooling agents). Examples of non-wax cooling agents include, but are not limited to, mint oil, cyclic a-keto enamines, aloe vera, chamomile, green tea, peppermint, lemon, eucalyptus and/or rose. In some embodiments, the skin care compositions excludes one or more of the cooling agents selected from mint oil, cyclic a-keto enamines, aloe vera, chamomile, green tea, peppermint, lemon, eucalyptus and/or rose.

[0105] Cooling agents (e.g., non-wax cooling agents), if present, may be included in the skin care composition in an amount from about 0.01 to about 4 wt.%, about 0.01 to about 3 wt.%, about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.1 wt.%; about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%, about 0.1 to about 0.1 wt.%; about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; about 0.75 to about 5 wt.%, about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%, about 0.75 to about 1 wt.%; about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; about 3 to about 5 wt.%, about 3 to about 4 wt.%, including any range or subrange therebetween, based on the total weight of the skin care composition.

[0106] The skin care composition may include one or more pH adjusters to increase or decrease the overall pH of the skin care composition. For example, one or more acids may be included to decrease the pH of the skin care composition. Examples of suitable acids for decreasing the pH of the skin care composition include, but are not limited to, citric acid, acetic acid, and the like. The skin care composition may include one or more bases, such as sodium hydroxide, potassium hydroxide and the like, to increase the pH of the skin care composition. Additional or alternative acids and bases that are suitable for adjusting the pH of the skin care composition are readily known to one of ordinary skill in the art.

[0107] The skin care composition may have a pH of about 3 to about 8. For example, in some embodiments, the skin care composition has a pH of about 3.5 to about 8, about 4 to about 8, about

4.5 to about 8, about 5 to about 8; from about 3 to about 7, about 3.5 to about 7, about 4 to about 7, about 4.5 to about 7, about 5 to about 7; from about 3 to about 6.5, about 3.5 to about 6.5, about 4 to about 6.5, about 4.5 to about 6.5, about 5 to about 6.5; from about 3 to about 6, about 3.5 to about 6, about 4 to about 6, about 4.5 to about 6, about 5 to about 6; from about 3 to about 5.5, about 3.5 to about 5.5, about 4 to about 5.5, about 4.5 to about 5.5; from about 3 to about 5, about

3.5 to about 5, about 4 to about 5, or any range or subrange thereof.

[0108] The amount of the pH adjuster in the skin care composition may be based on the desired pH of the final skin care composition and/or product. For example, the total amount of the pH adjuster may range from about 0.05 to about 20 wt.%, based on the total weight of the skin care composition. In some instances, the total amount of pH adjuster is from about 0.05 to about 15 wt.%, about 0.1 to about 10 wt.%, or about 0.12 to about 5 wt.%, including ranges and sub-ranges therebetween, based on the total weight of the skin care composition.

[0109] Additional ingredients may be present in the skin care composition. These include water and ingredients to thicken, preserve, emulsify, add fragrance, adjust the pH, and color. The skin care compositions may include any of the following additional ingredients in an amount of from about 0.01 to about 5 wt.%. In some instances, the amount of additional ingredients present in the skin care composition is from about 0.01 to about 4 wt.%, about 0.01 to about 3 wt.%, about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.1 wt.%; about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%, about 0.1 to about 0.1 wt.%; about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; about 0.75 to about 5 wt.%, about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%, about 0.75 to about 1 wt.%; about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; about 3 to about 5 wt.%, about 3 to about 4 wt.%, including any range or subrange therebetween, based on the total weight of the skin care composition.

[0110] The skin care composition can comprise additional ingredients, such as proteins (e.g., hydrolyzed vegetable protein, hydrolyzed wheat protein, hydrolyzed milk protein, hydrolyzed silk and hydrolyzed collagen), vitamins (e.g., panthenol, biotin, vitamin E acetate, vitamin A and D palmitate), moisturizers/humectants (e.g., glycerin, propylene glycol, sodium pyroglutamic acid (also known as PCA), amino acid-based surfactants, and HLA), emollients (e.g., esters, isopropyl myristate, decyl oleate, C12-15 alkyl benzoate), botanicals (e.g., chamomile, aloe, rosemary), as well as preservatives, dyes, pH adjusters and chelating agents. Additional examples of vitamins that may be included in some skin care compositions include tocopherol, retinol, and ascorbic acid. Vitamin derivatives, such as ascorbyl monopalmitate, tocopheryl acetate, and Vitamin E palmitate, may also be included in certain embodiments of the invention.

[0111] Non-limiting examples of fragrances and perfumes include odor compounds selected from: 7-acetyl-l,2,3,4,5,6,7,8-octahydro-l,l,6,7-tetramethylnaphthalene, a-ionone, [3-ionone, y-ionone a-isomethylionone, methylcedrylone, methyl dihydroj asm onate, methyl l,6,10-trimethyl-2,5,9- cyclododecatrien-l-yl ketone, 7-acetyl-l,l,3,4,4,6-hexamethyltetralin, 4-acetyl-6-tert-butyl-l,l- dimethylindane, hydroxyphenylbutanone, benzophenone, methyl [3-naphthyl ketone, 6-acetyl- 1 , 1 ,2, 3 , 3 , 5 -hexamethylindane, 5 -acetyl -3 -i sopropyl- 1 , 1 ,2, 6-tetram ethylindane, 1 -dodecanal, 4-(4- hydroxy-4-methylpentyl)-3-cyclohexene-l-carboxaldehyde, 7-hydroxy-3,7-dimethyloctanal, 10- undecen-l-al, isohexenylcyclohexylcarboxaldehyde, formyltricyclodecane, condensation products of hydroxycitronellal and methyl anthranilate, condensation products of hydroxy citronellal and indole, condensation products of phenylacetaldehyde and indole, 2-methyl- 3-(para-tert-butylphenyl)propionaldehyde, ethylvanillin, heliotropin, hexylcinnamaldehyde, amylcinnamaldehyde, 2-methyl-2-(isopropylphenyl)propionaldehyde, coumarin, y-decalactone, cyclopentadecanolide, 16-hydroxy-9-hexadecenoic acid lactone, 1,3,4,6,7,8-hexahydro- 4,6,6,7,8,8-hexamethylcyclopenta-y-2-benzopyran, [3-naphthol methyl ether, ambroxane, dodecahydro-3a,6,6,9a-tetramethylnaphtho[2, lb]furan, cedrol, 5-(2,2,3-trimethylcyclopent-3- enyl)-3-methylpentan-2-ol, 2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-l-yl)-2-buten-l-ol, caryophyllene alcohol, tricyclodecenyl propionate, tricyclodecenyl acetate, benzyl salicylate, cedryl acetate, and tert-butylcyclohexyl acetate.

[0112] Other fragrances may include odor compounds selected from essential oils, resinoids and resins from a large number of sources, such as, for example, Peru balsam, olibanum resinoid, styrax, labdanum resin, nutmeg, cassia oil, benzoin resin, coriander, and lavandin.

[0113] Further suitable fragrances include odor compounds selected from phenylethyl alcohol, terpineol, linalool, linalyl acetate, geraniol, nerol, 2-(l,l-dimethylethyl)cyclo-hexanol acetate, benzyl acetate, and eugenol. The fragrances or perfumes can be used as single substances or in a mixture with one another.

[0114] The skin care composition may further comprise one or more colorants. The colorants may be a pigment, a dye, or mixtures thereof. Non-limiting examples of pigments include titanium dioxide, zinc oxide, kaolin, mica etc. Non-limiting examples of dyes include food dyes suitable for food, drug and cosmetic applications, and mixtures thereof. Some color agents (colorants) are known as FD&C dyes.

[0115] The colorants may be present in an amount ranging from about 0.0001 to about 0.4 wt.%, including all percentages and subranges therebetween, based on the total weight of the skin care composition. In some embodiments, the colorants may be present in an amount ranging from about 0.0001 to about 4 wt.%, including all percentages and subranges therebetween, based on the total weight of the skin care composition.

[0116] In certain embodiments, in order to prevent ingredients from separating, emulsifiers may be added. In certain embodiments, additional ingredients may include conditioning agents that moisturize the skin during and after use of the skin care composition. [0117] In other embodiments, the composition may include any of following materials in any desired amount to achieve a desired effect in the composition (amounts that can be used in some embodiments are provided): one or more alkaline salts, for example, sodium chloride, sodium sulfate, sodium carbonate, sodium bicarbonate and/or their equivalents (0 to 5% by weight); sequestrants, for example, tetrasodium EDTA, and/or their equivalents (0 to 2% by weight); biocides, for example, Triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether), DMDM hydantoin, formaldehyde and/or imidazolidinyl urea, and/or their equivalents (0 to 2% by weight); organic acids, for example, citric acid and/or formic acid and/or their equivalents (0 to 2% by weight); viscosity modifiers (0 to 2% by weight); fragrances and/or perfumes (0 to 5% by weight); preservatives, for example, phenoxyethanol, formaldehyde solution, parabens, pentanediol or sorbic acid (0 to 2% by weight); pearlizing agents, for example, glycol distearic esters, such as ethylene glycol distearate, but also fatty acid monoglycol esters (0 to 3% by weight); stabilizers, for example, metal salts of fatty acids, such as e.g. magnesium stearate, aluminum stearate and/or zinc stearate (0 to 2% by a weight); and dyes and pigments that are approved and suitable for cosmetic purposes.

EXAMPLES

Example 1

[0118] A non-limiting example composition (Example Composition A) was prepared in the form of a serum in accordance with aspects of the invention. The formulation for Example Composition A is shown in Table 1.

Table 1

Example 2

[0119] In vivo evaluations were performed to assess Example Composition A on wounded skin. Specifically, human skin explants were wounded using an ablative laser. The ablative laser treatments produced 200 pm wounds covering a 14x14 mm² area with 10% coverage. After laser wounding, 20pL samples of either water, Example Composition A, or a Placebo Composition were applied and spread with an inoculation loop. The Placebo Composition was similar to Example Composition A, but did not include the inventive combination of ingredients included in Example Composition A. Tissues were harvested at different time-points over 48 hours and processed for the hematoxylin and eosin staining to visualize the wound healing. FIG. 1 provides images of the skin explants after receiving the application of water (a control), the Placebo Composition, or Example Composition A.

Example 3 [0120] Example Composition A was further evaluated to assess its effect on wounded skin. Specifically, human skin explants were washed, dried, and the epidermis was carefully and partially removed using a diamond burr tip to wound the skin samples. From the de-epidermized skin explant, samples having a size of 8x3 mm (0 x thickness) were collected, in order to maintain the cut in the middle, with an electronic puncher and cultured up to the planned endpoints. The skin samples were cultured in an air-liquid interface in a perforated ring of stainless steel in contact with culture medium (modified Williams’ E medium) up to planned time-points.

[0121] A 6 pl sample of water, Example Composition A, or Placebo Composition was applied to the skin samples. The skin samples were then stained using hematoxylin eosin staining and then statistically analyzed. The measures of variation as standard deviation and standard error of mean (sem) were applied to the original scores. Differences between groups were evaluated by one-way ANOVA with a permutation test followed by Tukey's and t-test with permutation when allowed. The reduction of the wound width for the skin samples after receiving Example Composition A, Placebo Composition, or water is summarized and shown in FIG. 2.

Claims

CLAIMS What is Claimed is:

1. A skin care composition comprising: palmitoyl sh-tripeptide-3 amide; a hyaluronic acid and/or a salt thereof; a lipid mimetic; and an amino acid system.

2. The skin care composition according to claim 1, wherein the palmitoyl sh-tripeptide-3 amide is present in an amount from about 0.005 to about 1 wt.%, the hyaluronic acid and/or the salt thereof is present in an amount from about 0.1 to about 1.5 wt.%, the lipid mimetic is present in an amount from about 1 to about 9 wt.%, and the amino acid system is present in an amount from about 1 to about 5 wt.%, wherein all weight percentages are based on the total weight of the skin care composition.

3. The skin care composition according to claim 1 or claim 2, wherein the hyaluronic acid and/or the salt thereof is selected from an acetylated hyaluronic acid and/or a salt thereof.

4. The skin care composition according to any foregoing claim, wherein the lipid mimetic comprises one or more of jojoba oil/macadamia seed oil ester, squalene, phytosterylmacadamiate, or phytosterol.

5. The skin care composition according to any foregoing claim, wherein the lipid mimetic comprises jojoba oil/macadamia seed oil ester, squalene, and phytosterylmacadamiate.

6. The skin care composition according to claim 4 or claim 5, wherein the jojoba oil/macadamia seed oil esters and squalene are present in the skin care composition in a weight ratio of the jojoba oil/macadamia seed oil esters to the squalene of about 1 :2 to about 1 : 15.

7. The skin care composition according to any foregoing claim, wherein the amino acid system comprises two or more amino acids selected from the group consisting of arginine, lysine, serine, citrulline, ornithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, alanine, aminobutyrate, asparagine, cysteine, cystine, glutamine, glycine, hydroxyproline, isoleucine, leucine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, valine, and a combination of two or more thereof.

8. The skin care composition according to any foregoing claim, wherein the amino acid system comprises two or more of arginine, lysine, glycine, taurine, or tyrosine.

9. The skin care composition according to any foregoing claim, wherein the amino acid system comprises arginine, glycine, and taurine.

10. The skin care composition according to any foregoing claim further comprising: a fatty alcohol, optionally, present in an amount from about 1 to about 9 wt.%, based on the total weight of the skin care composition.

11. The skin care composition according to claim 10, wherein the fatty alcohol comprises octyldodecanol.

12. The skin care composition according to any foregoing claim further comprising: a polyol, optionally, present in an amount from about 2 to about 15 wt.%, based on the total weight of the skin care composition.

13. The skin care composition according to claim 12, wherein the polyol is selected from ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, glycerin, diglycerin, diethylene glycol, dipropylene glycol, sorbitol, pentylene glycol, caprylyl glycol, 1,2-hexanediol, 1,2-pentanediol, and a combination of two or more thereof.

14. The skin care composition according to any foregoing claim further comprising: from about 60 to about 90 wt.% of water, based on the total weight of the skin care composition.

15. A skin care composition comprising: palmitoyl sh-tripeptide-3 amide; an acetylated hyaluronic acid and/or a salt thereof; a lipid mimetic; an amino acid system; and from about 60 to about 90 wt.% of water, wherein all weight percentages are based on the total weight of the skin care composition.

16. The skin care composition according to any foregoing claim further comprising: an andiroba oil, optionally, present in an amount from about 0.1 to about 5 wt.%.

17. A skin care composition comprising: palmitoyl sh-tripeptide-3 amide; a lipid mimetic; from about 0.1 to about 10 wt.% of a hydrophobic component, the hydrophobic component comprising andiroba oil; and from about 60 to about 90 wt.% of water, wherein all weight percentages are based on the total weight of the skin care composition.

18. The skin care composition according to claim 17 further comprising: an amino acid system, optionally, present in an amount from about 1 to about 5 wt.%.

19. The skin care composition according to claim 17 or claim 18, wherein the amino acid system comprises arginine, glycine, and taurine.

20. The skin care composition according to any one of claims 17 to 19, wherein the hydrophobic component further comprises octyldodecanol.