WO2024148339A1 - Utilisation d'un anticorps multimère anti-dr5 pour le traitement du cancer - Google Patents
Utilisation d'un anticorps multimère anti-dr5 pour le traitement du cancer Download PDFInfo
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- QQHMKNYGKVVGCZ-UHFFFAOYSA-N tipiracil Chemical compound N1C(=O)NC(=O)C(Cl)=C1CN1C(=N)CCC1 QQHMKNYGKVVGCZ-UHFFFAOYSA-N 0.000 description 1
- 229960002952 tipiracil Drugs 0.000 description 1
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- 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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- 238000013519 translation Methods 0.000 description 1
- 230000001296 transplacental effect Effects 0.000 description 1
- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 1
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Abstract
L'invention concerne des procédés thérapeutiques pour inhiber, retarder ou réduire la croissance de cellules malignes chez un sujet atteint d'un cancer par administration d'une polythérapie comprenant un anticorps anti-DR5 multimère et le FOLFIRI. L'invention concerne également des procédés d'inhibition, de retardement ou de réduction de la croissance de cellules malignes chez un sujet atteint d'un cancer par l'administration d'un anticorps anti-DR5 multimère, l'administration de l'anticorps anti-DR5 n'entraînant pas une toxicité hépatique significative.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63/478,766 | 2023-01-06 | ||
US63/505,687 | 2023-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2024148339A1 true WO2024148339A1 (fr) | 2024-07-11 |
Family
ID=
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