WO2024146467A1 - Ampoule and vial integrated filling system and control method - Google Patents

Abstract

An ampoule and vial integrated filling system and a control method, belonging to the technical field of biomedical apparatuses. The system comprises: successively arranged, a feeding mesh belt assembly, a feeding screw assembly, a feeding star wheel assembly, an inlet plum-blossom star wheel, a needle holder assembly, an outlet plum-blossom assembly, a sampling and rejecting assembly, a discharging screw assembly and a control system. The control system is separately connected to the feeding mesh belt assembly, the feeding screw assembly, a filling system assembly, the needle holder assembly, a fire frame assembly, a wire drawing assembly, a rubber stopper supplying system assembly, a stopper pressing assembly and the discharging screw assembly. The present invention ingeniously integrates two filling systems for ampoules and vials, so that the occupied area of the filling system is remarkably reduced, and the filling system can be installed in workshops of different types, achieving higher applicability.

Description

An ampoule and vial integrated filling system and control method Technical Field

The present invention relates to an ampoule-vial integrated filling system and a control method, belonging to the technical field of biomedical equipment. The present invention defines the direction mentioned in the present invention as a direction perpendicular to a horizontal plane from top to bottom.

Background technique

At present, the existing filling machines in the pharmaceutical equipment market can only meet the filling needs of vials or ampoules separately. As the market demands for diversified product packaging materials, a one-machine multi-purpose filling machine that can simultaneously fill vials and ampoules is particularly important. Therefore, this technical field urgently needs to obtain an ampoule and vial integrated filling system that can simultaneously meet the filling needs of ampoules and vials. Simply by changing the mold specifications and adjusting the filling program, the filling needs of different types of bottles and bottle types can be met, thus realizing the dual-purpose function of one machine.

Summary of the invention

The purpose of the present invention is to solve the technical problem of how to obtain an ampoule and vial integrated filling system that can be compatible with the filling requirements of both ampoules and vials.

In order to achieve the purpose of solving the above-mentioned problems, the technical solution adopted by the present invention is to provide an integrated filling system for ampoules and vials, including a feed mesh belt assembly, a feed screw assembly, a feed star wheel assembly, an inlet plum blossom star wheel, a needle rack assembly, an outlet plum blossom assembly, a sampling and rejection assembly, a discharge screw assembly and a control system which are arranged in sequence; a filling system assembly is arranged adjacent to the needle rack assembly; a bottle feeding assembly and a bottle protection assembly are arranged adjacent to the inlet plum blossom star wheel; a fire rack assembly and a wire drawing assembly are arranged in sequence between the needle rack assembly and the outlet plum blossom assembly; a plug feeding system assembly and a plug pressing assembly are arranged adjacent to the outlet plum blossom assembly; an ampoule discharge assembly and a penlet bottle discharge assembly are respectively arranged at the outlet end of the discharge screw assembly; the control system is respectively connected to the feed mesh belt assembly, the feed screw assembly, the filling system assembly, the needle rack assembly, The fire rack assembly, the wire drawing assembly, the rubber plug feeding system assembly, the plug pressing assembly and the discharging screw assembly are connected.

Furthermore, it includes a working platform and an isolation wall surrounding the working platform, the isolation wall, the working platform and the ceiling form an isolation space, the operating parts of each component in the filling system are above the working platform, and the driving and power supply parts are arranged below the working platform.

Furthermore, the feed mesh belt assembly stores and transports ampoules or vials input from an upstream process to the feed star wheel assembly.

Furthermore, the feed mesh belt assembly includes a first fence, a second fence, a feed mesh belt and an arc-shaped tensioning spring; the first fence, the second fence and the feed screw assembly form a "凵" shape, with their opening direction facing the upstream feed port; a transport mesh belt is also laid flat inside the first fence, the second fence and the feed screw assembly, and its transport direction is perpendicular to the axial direction of the feed screw, and the arc-shaped tensioning spring is vertically arranged on the feed mesh belt, one side is connected to the first fence, and the other side is connected to the second fence.

Furthermore, the needle holder assembly is provided with a servo motor and a transmission screw for up and down movements to cooperate with the filling system assembly to perform nitrogen filling and filling actions on the packaging material.

Furthermore, the filling system component is connected to the fire rack component and the wire drawing component through a control system.

Furthermore, a rotating bottle assembly is provided between the fire rack assembly and the wire drawing assembly, and the rotating bottle assembly includes a rotating bottle base, and a turntable with a rotating shaft protruding above the rotating bottle base; a first driving rod is connected to the bottom of the rotating bottle base, the first driving rod is connected to the first driving wheel, and the first driving wheel is connected to the first servo motor, and the first servo motor can drive the first driving wheel to rotate, thereby driving the turntable to rotate.

Furthermore, the fire rack assembly includes a nozzle rack, a nozzle opening is arranged on the upper side of the nozzle rack, the lower side of the nozzle rack is connected to a second driving rod, the second driving rod is connected to a second driving wheel, the second driving wheel itself rotates to drive the second driving rod to move up and down; the second driving wheel is connected to a second servo motor; the rotating bottle assembly is arranged on the nozzle opening side of the fire rack assembly, the second driving motor drives the nozzle rack to move downward, and can align the nozzle opening with the neck position of the ampoule arranged on the turntable.

Furthermore, a first driving swing arm and a second driving swing arm are provided outside the first driving wheel, one side of the first driving swing arm and the second driving swing arm are hinged to each other, and the other sides of the first driving swing arm and the second driving swing arm are connected to the adjacent sides of the first driving wheel; the lower part of the first driving rod is connected to the first driving swing arm.

Furthermore, the wire drawing assembly includes a wire drawing frame, a rotating assembly is provided on the wire drawing frame, a wire drawing clamp is provided on the rotating assembly, the lower side of the wire drawing frame is connected to a third driving rod, the third driving rod is connected to a third driving wheel, the third driving wheel itself rotates to drive the third driving rod to move up and down; the third driving wheel is connected to a third servo motor; the third servo motor drives the wire drawing frame to move up and down.

Furthermore, a sealed shell is arranged behind the wire drawing frame, and the sealed shell includes a first sealed container and a second sealed container which are fixedly connected up and down; the upper section of the third driving rod is arranged in the first sealed container, and the lower end of the third driving rod is arranged in the second sealed container, and a first through hole for the third driving rod to pass through is provided at the junction of the first sealed container and the second sealed container; a spring member is arranged on the outer sleeve of the upper section of the third driving rod, and the diameter of the spring member and the upper end area of the third driving rod are greater than the diameter of the through hole; the lower edge of the sealed shell is against the top of the working platform; and a second through hole for the third driving rod to pass through is provided on the lower edge, and a sealing O-ring is provided at the junction with the second through hole.

Furthermore, the rotating assembly also includes a main body bracket, and a first rotating shaft, a second rotating shaft and a third rotating shaft rotatably connected in the main body bracket, the first rotating shaft and the second rotating shaft are arranged side by side below the third rotating shaft, the wire drawing pliers clamp is composed of a plurality of single-sided components which are respectively arranged on the first rotating shaft and the second rotating shaft facing each other, the same side of the first rotating shaft and the second rotating shaft are respectively rotatably connected to the main body bracket through mutually meshing first gears, and the wire drawing pliers clamp is opened or closed by rotating the first rotating shaft and the second rotating shaft; the third rotating shaft can flip the rotating assembly as a whole to one side; the end of the main body bracket close to the first gear side has a damping structure embedded therein; the first gear end side of the first rotating shaft is wound around one side of the first steel strand, and the other side of the first steel strand is wound around the top of the third driving rod; the The end side of the third rotating shaft is wound around one side of the second steel strand, and the other side of the second steel strand is wound around the top of the third driving rod; the third steel strand and the fourth steel strand are connected between the bottom of the third driving rod and the third driving wheel.

Furthermore, the third driving wheel faces the third servo motor and includes a clamping cam, a swing frame cam and a clamp opening cam in sequence; the clamping cam drives the wire drawing frame to move up and down; the swing frame cam drives the clamp to swing back and forth by connecting with the fourth steel strand; the clamp opening cam is connected with the third steel strand to drive the wire drawing clamp to open or close; the third driving rod includes a left driving rod and a right driving rod, the upper side of the left driving rod is connected to the first steel strand, and the lower side is connected to the third steel strand, the upper side of the right driving rod is connected to the second steel strand, and the lower side is connected to the fourth steel strand.

Furthermore, an "L"-shaped guide plate and a guide wheel arranged between the guide plates are provided in the direction of the steel strand leading to the driving wheel. One side of the guide plate is connected to the lower side of the sealing shell, and the other side is connected to the third driving wheel. The third steel strand and the fourth steel strand bypass the guide wheel and are connected to the third driving wheel.

Furthermore, a retraction rod assembly is provided between the clamping cam and the wire drawing frame, and the retraction rod assembly includes a retraction shell, a displacement rod arranged in the retraction shell and movable up and down, a bearing platform is provided at the upper end of the displacement rod, and the rod body of the displacement rod relies on the clamping cam, and utilizes the self-rotation of the clamping cam to drive the displacement rod to move upward or downward.

Furthermore, a slag discharge assembly is arranged opposite to the fire rack assembly; the slag discharge assembly comprises a first slag discharge channel with an opening at the top, a sealed bin is connected to the bottom of the first slag discharge channel, the sealed bin is provided with a movable bottom plate, a bottom plate driving rod is provided on one side of the movable bottom plate, the bottom plate driving rod passes through the side wall of the sealed bin and is connected to an external driving cylinder, and the driving cylinder is fixedly connected to a limit plate; a second slag discharge channel is arranged under the movable bottom plate, a sealed slag box is arranged at the outlet of the second slag discharge channel, an opening is arranged above the slag box which is connected to the outlet of the second slag discharge channel and is airtightly connected to the second slag discharge channel, a track is laid at the bottom of the slag box, a slag trolley with rollers is provided on the track, the slag trolley is used to receive the residue dropped from the second slag discharge channel, a sealed front door is provided on the front side of the slag box, and a sensor is matched with the sealed front door. When the sensor senses that the sealed front door is open, the control system is notified to drive the cylinder to close the movable bottom plate. When the sensor senses that the sealed front door is closed, the movable bottom plate is restored to its original open state.

Furthermore, an exhaust assembly is provided on the slag discharge assembly, and the exhaust assembly includes a wind scoop, a pneumatic butterfly valve and a heat exhaust channel connected in sequence from bottom to top; a heat exhaust fan and a fan housing arranged outside the heat exhaust fan are arranged together on one side of the heat exhaust channel.

Furthermore, the filling system component is connected with the rubber plug feeding system component and the plug pressing component through a control system.

Furthermore, the filling system component is connected to the discharging screw component through a control system; the discharging screw component is respectively connected to the ampoule discharging component or the vial discharging component.

Further, a filling control method for an ampoule and a vial is provided: the control method is based on any one of the above-mentioned filling systems for an ampoule and a vial. When the container bottle to be filled is an ampoule, the ampoule filling mode is opened by the control system, and the screw member of the feed screw assembly, the gear member of the feed star wheel assembly, the guardrail member of the bottle guard assembly, the gear member of the inlet plum blossom star wheel and the gear member of the outlet plum blossom assembly are replaced to be suitable for the operation of the ampoule; in the ampoule filling mode, the control system controls the operation of the feed mesh belt assembly, the feed screw assembly, the feed star wheel assembly, the inlet plum blossom star wheel, the filling system assembly, the needle rack assembly, the fire rack assembly, the wire drawing assembly, the outlet plum blossom assembly, the discharge screw assembly and the ampoule discharge assembly;

When the container bottle to be filled is a vial, the vial filling mode is turned on through the control system, and the screw member of the feed screw assembly, the gear member of the feed star wheel assembly, the guardrail member of the bottle guard assembly, the gear member of the inlet plum blossom star wheel and the gear member of the outlet plum blossom assembly are replaced to be suitable for the operation of the vial; in the ampoule filling mode, the control system controls the operation of the feed mesh belt assembly, the feed screw assembly, the feed star wheel assembly, the inlet plum blossom star wheel, the filling system assembly, the needle holder assembly, the outlet plum blossom assembly, the stopper feeding system assembly, the plug pressing assembly, the discharging screw assembly and the vial discharging assembly;

The feeding mesh belt assembly conveys the container bottles to the feeding screw assembly, and the feeding screw assembly changes the conveying direction of the container bottles, and conveys the container bottles one by one to the feeding star wheel assembly. The feeding star wheel assembly conveys the container bottles to the inlet plum blossom star wheel by rotating, and the inlet plum blossom star wheel The container bottle is transported to the filling system assembly and the needle holder assembly for nitrogen filling and drug filling; the bottle delivery assembly and the bottle protection assembly clamp the container bottle in the groove of the bottle delivery assembly, and the guardrail of the bottle protection assembly is used for protection, and the container bottle is transported to the relevant process assembly for processing; finally, the container bottle is transported to the corresponding outlet by the discharge screw assembly;

The fire rack assembly heats the bottleneck of the ampoule bottle to melt it, and the wire drawing assembly throws the residue of the ampoule bottle to the slag discharge assembly;

The stopper feeding system assembly is a container for storing stopper caps, and the stopper caps are transferred to the upper part of the plugging assembly in a rotating manner in the container. When the vial is conveyed to the bottom of the plugging assembly, the plugging assembly is pressed down as a whole to seal the stopper cap at the upper end of the vial.

The beneficial effects of this program are:

1) The present invention significantly reduces the floor space occupied by the filling system by cleverly combining the two filling systems of the ampoule bottle and the vial, and can be installed in different types of factory buildings, thus having greater applicability.

2) The present invention provides sealing facilities in the wire drawing assembly, the slag removal assembly, and the exhaust assembly, so that the cleanliness requirements of the ampoule filling equipment meet the cleanliness requirements of the vial filling, thereby achieving one system applicable to two different bottle types.

BRIEF DESCRIPTION OF THE DRAWINGS

Other features, objects and advantages of the present invention will become more apparent from the detailed description of non-limiting embodiments made with reference to the following drawings:

FIG1 is a schematic structural diagram of an ampoule and vial integrated filling system in an embodiment of the present invention;

FIG2 is a schematic structural diagram of a feed mesh belt assembly in an embodiment of the present invention;

FIG3 is a schematic structural diagram 1 of a fire rack assembly, a wire drawing assembly and a bottle rotating assembly in an embodiment of the present invention;

FIG4 is a structural schematic diagram 2 of a fire rack assembly, a wire drawing assembly and a bottle rotating assembly in an embodiment of the present invention;

FIG5 is a schematic structural diagram 1 of a wire drawing assembly according to an embodiment of the present invention;

FIG6 is a structural schematic diagram 2 of a wire drawing assembly according to an embodiment of the present invention;

FIG7 is a schematic structural diagram of a sealed housing according to an embodiment of the present invention;

FIG8 is a schematic structural diagram of a rotating assembly according to an embodiment of the present invention;

FIG9 is a schematic diagram of the partial structure of section A in FIG8 ;

FIG10 is a schematic structural diagram 1 of a slag discharge assembly according to an embodiment of the present invention;

FIG11 is a schematic structural diagram 2 of a slag discharge assembly according to an embodiment of the present invention;

FIG12 is a schematic structural diagram 1 of an exhaust assembly according to an embodiment of the present invention;

FIG13 is a schematic structural diagram 2 of an exhaust assembly according to an embodiment of the present invention;

14 is a schematic structural diagram of a bottle rotating assembly according to an embodiment of the present invention;

15 is a schematic structural diagram of a needle holder assembly according to an embodiment of the present invention;

FIG16 is a structural schematic diagram 3 of a wire drawing assembly according to an embodiment of the present invention;

17 is a schematic diagram of the structure of the fire rack assembly in an embodiment of the present invention;

Description of reference numerals: 1. Feeding mesh belt assembly; 101 first fence; 102 second fence; 103 transporting mesh belt; 104 arc-shaped tensioning spring; 105 feeding port; 2. feeding screw assembly; 3. feeding star wheel assembly; 4. inlet plum blossom star wheel; 5. bottle delivery assembly; 6. bottle protection assembly; 7. filling system assembly; 8. needle rack assembly; 9. fire rack assembly; 901. nozzle rack; 902. nozzle port; 903. second driving rod; 904. second driving wheel; 905. Second servo motor; 906 First drive swing arm; 907 Second drive swing arm; 10. Wire drawing assembly; 1001. Wire drawing frame; 1002. Rotating assembly; 10021. Main frame; 10022. First rotating axis; 10023. Second rotating axis; 10024. Third rotating axis; 10025. First gear; 10026. Damping structure; 1003. Wire drawing clamp; 1004. Third driving rod; 10041. Left driving rod; 10042. right drive rod; 1005. third drive wheel; 10051. clamping cam; 10052. swing frame cam; 10053. clamp opening cam; 1006. third servo motor; 11. outlet plum blossom assembly; 12. plug feeding system assembly; 13. plug pressing assembly; 14. sampling and rejecting assembly; 15. discharging screw assembly; 16. ampoule discharging assembly; 17. vial discharging assembly; 18. working platform; 19. isolation wall; 2 0. bottle spinner assembly; 201. bottle spinner base; 202. turntable; 203 first drive rod; 204. first drive wheel; 205. first servo motor; 21. sealed housing; 211. first sealed container; 212 second sealed container; 213. first through hole; 216. sealing O-ring; 217. first steel strand; 218. second steel strand; 219. third steel strand; 220. fourth steel strand; 221. guide plate; 222. guide wheel; 223. Retracting rod assembly; 224. Retracting shell; 225. Displacement rod; 226. Carrying platform; 23. Slag discharge assembly; 231. First slag discharge channel; 232. Sealing bin; 233. Movable bottom plate; 234. Bottom plate driving rod; 235. Driving cylinder; 236 Limiting plate; 237 Second slag discharge channel; 238. Sealed slag box; 239. Track; 240. Slag trolley; 241 Sealed front door; 242 Sensor; 25. Exhaust assembly; 251. Wind bucket; 252. Pneumatic butterfly valve; 253. Heat exhaust fan; 254. Fan housing; 255. Heat exhaust channel.

Detailed ways

The present invention is further described in detail below in conjunction with the accompanying drawings.

Those skilled in the art will readily appreciate other embodiments of the present invention after considering the specification and practicing the invention disclosed herein. This application is intended to cover any variations, uses or adaptations of the present invention that follow the general principles of the present invention and include common knowledge or customary techniques in the art that are not disclosed in this disclosure. The specification and examples are intended to be exemplary only, and the true scope and spirit of the present invention are indicated by the claims.

The container bottle described in the present invention includes any one of an ampoule bottle or a vial, or both of them are applicable.

As shown in Figure 1, the present invention provides an integrated filling system for ampoules and vials, comprising a feed mesh belt assembly 1, a feed screw assembly 2, a feed star wheel assembly 3, an inlet plum blossom star wheel 4, a needle rack assembly 8, an outlet plum blossom assembly 11, a sampling and rejection assembly 14, a discharge screw assembly 15 and a control system which are sequentially arranged; a filling system assembly 7 is arranged adjacent to the needle rack assembly 8; a bottle delivery assembly 5 and a bottle protection assembly 6 are arranged adjacent to the inlet plum blossom star wheel 4; a fire rack assembly 9 and a wire drawing assembly 10 are sequentially arranged between the needle rack assembly 8 and the outlet plum blossom assembly 11; a plug feeding system assembly 12 and a plug pressing assembly 13 are arranged adjacent to the outlet plum blossom assembly 11; an ampoule discharge assembly 16 and a vial discharge assembly 17 are respectively arranged at the outlet end of the discharge screw assembly 15. In this embodiment, the ampoule filling system and the vial filling system are cleverly combined into one system through design. The feed mesh belt assembly 1, the feed screw assembly 2, the feed star wheel assembly 3, the inlet plum blossom star wheel 4, the needle holder assembly 8, the outlet plum blossom assembly 11, the sampling and rejecting assembly 14, and the discharge screw assembly 15 are connected adjacently from one side to the other side in sequence, which can not only efficiently realize the feeding, filling, sealing and other operations of various bottle types, but also The order of arranging the devices in this way, with two devices adjacent to each other, further reduces the footprint of the production system, making it suitable for use in workplaces in more scenarios.

Furthermore, it includes a working platform 18, and an isolation wall 19 surrounding the working platform 18, the isolation wall 19, the working platform 18 and the ceiling form an isolation space, the operating parts of each component in the filling system are above the working platform 18, and the drive and power supply parts are arranged below the working platform 18. In this embodiment, since ampoules and vials are to be combined in one system for filling, but the filling of vials has higher requirements for environmental cleanliness than that of ampoules, in order to be compatible with the cleanliness requirements of two different bottle types, it is necessary to improve the cleanliness requirements required for the filling of ampoules. The above is done through the working platform 18 and the isolation wall 19, the isolation wall 19 is usually made of transparent glass, and the ceiling or the top of the house itself, forming a physical isolation, forming an incompletely sealed state, and each component is operated and operated in this isolation space, meeting the cleanliness requirements of component operation, and the operator can make necessary interventions through gloves and opened windows.

The control system is connected to the feed mesh belt assembly 1, the feed screw assembly 2, the filling system assembly 7, the needle rack assembly 8, the fire rack assembly 9, the wire drawing assembly 10, the plug feeding system assembly 12, the plug pressing assembly 13 and the discharge screw assembly 15 respectively. The feed mesh belt assembly 1 stores and transports the ampoules or vials input from the upstream process to the feed star wheel assembly 3. The needle rack assembly 8 is provided with a servo motor and a transmission screw for up and down movements to cooperate with the filling system assembly 7 to perform nitrogen filling and filling actions on the packaging material. The filling system assembly 7 is connected to the fire rack assembly 99 and the wire drawing assembly 10 through the control system. The filling system assembly 7 is connected to the plug feeding system assembly 12 and the plug pressing assembly 13 through the control system. The filling system assembly 7 is connected to the discharge screw assembly 15 through the control system; the discharge screw assembly 15 is connected to the ampoule discharge assembly 16 or the vial discharge assembly 17 respectively.

Example

As shown in Figures 1-5, the purpose of the present invention is to provide an ampoule and vial integrated filling system that can be compatible with the filling needs of ampoules and vials (two bottle types) to achieve a dual-purpose filling function in one machine.

The present invention provides an ampoule and vial integrated filling system, comprising a feed mesh belt assembly 1, a feed screw assembly 2, a feed star wheel assembly 3, an inlet plum blossom star wheel 4, a bottle delivery assembly 5, and a bottle protection assembly. 6. Filling system assembly 7, needle holder assembly 8, fire holder assembly 9, wire drawing assembly 10, outlet plum blossom assembly 11, stopper feeding system assembly 12, plug pressing assembly 13, sampling and rejecting assembly 14, discharging screw assembly 15, ampoule discharging assembly 16 and vial discharging assembly 17.

The functions of the above components are:

In the control system of this filling system, there are two preset filling modes, namely, the ampoule filling system and the vial filling system; the staff selects the bottle type to be filled this time and starts the filling system.

The feeding mesh belt assembly 1 is used to store and transport packaging materials (ampoules or vials) cleaned and sterilized by the bottle washing machine and tunnel oven from upstream. The feeding mesh belt assembly stores container bottles and can shrink the distance between two adjacent container bottles until the bottles are close to each other. At the same time, the feeding mesh belt assembly transports the container bottles input from the upstream process to the feeding star wheel assembly.

As shown in Figure 2, further, the feed mesh belt assembly 1 includes a first fence 101, a second fence 102, a feed mesh belt and an arc-shaped tensioning spring 104; the first fence 101, the second fence 102 and the feed screw assembly 2 form a "凵" shape, and its opening direction is toward the upstream feed port 105; the first fence 101, the second fence 102 and the feed screw assembly 2 are also flatly laid with a transport mesh belt 103, and its transport direction is perpendicular to the axial direction of the feed screw, and the arc-shaped tensioning spring 104 is vertically arranged on the feed mesh belt, one side is connected to the first fence 101, and the other side is connected to the second fence 102. In this embodiment, since the integrated machine receives different bottle types from the discharge port, the collision volume and height of the ampoule bottle and the vial are different. If they are too loose or tight, they may fall over. The present invention adopts an arc-shaped tensioning spring 104, which uses its own elasticity to produce a certain low-amplitude vibration. When the bottle is pushed toward the arc-shaped tensioning spring 104, it will not only be dispersed by the vibration, but the arc can also guide the bottle to move more smoothly. Through testing, it can not only effectively disperse the ampoule bottle, but also effectively disperse the vial, so that the bottle moves toward the feeding screw assembly 2. The movement state of each bottle is basically consistent, which is better adapted to the integrated machine provided by the present invention. In this embodiment, the arc-shaped tensioning spring 104 is made of aluminum. Compared with the prior art that uses a vibrator to generate a vibration source to prevent the bottle from falling over, the present invention can be completed with only one spring, which significantly reduces the cost of production.

The feed screw assembly 2 and the feed star wheel assembly 3 are used to convey the packaging materials conveyed by the feed mesh belt assembly 1, so that the ampoules or vials are arranged at equal intervals and conveyed to the feed star wheel assembly 3 at a uniform speed.

Furthermore, the feed screw assembly 2 includes at least a detachable feed screw, and the feed star wheel assembly 3, the inlet plum blossom star wheel 4 and the sampling and rejecting assembly 14 include at least a detachable star wheel. In this embodiment, since the filling system needs to meet the transportation of ampoules and vials, the widths of ampoules and vials are different; therefore, the feed screw and star wheel need to be replaced according to the specific bottle type to be transported, so that the size of the feeding trough on their parts can match the width of the ampoules and vials; only by replacing some parts, the system can take into account the transportation of both types of bottles, greatly reducing production costs and reducing the space occupied by production equipment.

The inlet plum blossom star wheel 4 can transport the three groups of vials from the feed star wheel assembly 3 to the filling stations in an intermittent motion manner.

The bottle delivery assembly 5 and the bottle protection assembly 6 intermittently transfer and convey the packaging materials through the cooperation of the bottle delivery assembly and the bottle protection assembly 6. The bottle protection assembly 6 transports the container bottles to the corresponding process treatment assembly through the inlet plum blossom star wheel 4 assembly.

As shown in FIG15 , the needle holder assembly 8 has the following functions: the needle holder assembly 8 can perform nitrogen filling and filling actions on the packaging material through the up and down movements of the servo motor and the transmission screw rod, in cooperation with the filling system assembly 7. The filling system assembly 7 selects different filling systems (peristaltic pump/plunger pump) according to different characteristics of the drug solution.

Furthermore, the filling system component 7 includes a first nitrogen filling valve, a second nitrogen filling valve and a third nitrogen filling valve. According to the moving direction of the bottle body, the first nitrogen filling valve is a common valve; the second nitrogen filling valve is used for post-nitrogen filling of an ampoule bottle; and the third nitrogen filling valve is used for post-nitrogen filling of a vial. In this embodiment, regardless of whether it is an ampoule bottle or a vial, the first nitrogen filling valve needs to blow out the air in the bottle; due to different processes, the second nitrogen filling valve is only opened when the bottle type is an ampoule bottle; and the third nitrogen filling valve is also only opened when it is a vial.

The filling pump used in this system is a peristaltic pump. The filling volume needs to be calibrated before production. When weighing and testing the container bottle after filling, if there is a large difference between the filling volume and the system set volume, the hose on the peristaltic pump needs to be replaced and the capacity calibration needs to be performed.

After filling, the subsequent processes will be different depending on the type of bottle, especially the sealing part. Ampoules and vials are different: the sealing of ampoules is through heating and drawing. After the filling, vials need to be plugged. After the plugging is completed, it is necessary to judge whether they need to be discarded based on the plugging situation.

As shown in Figure 17, the function of the fire rack assembly 9 is: when filling ampoules, the control system sends an instruction to fill the ampoules through the filling program, and the electrical signal controls the fire rack assembly 9 to operate, and the flame emitted by the fire rack assembly 9 heats the upper end of the ampoule packaging material for a limited time; if filling vials, the fire rack assembly 9 does not operate.

As shown in FIG16 , the function of the wire drawing assembly 10 is as follows: when filling an ampoule bottle, the wire drawing assembly 10 performs a sealing action according to the instruction given by the filling program issued by the control system, and performs wire drawing and sealing on the ampoule bottle heated by the fire rack; when filling a vial, the wire drawing assembly 10 does not act.

As shown in Figures 3, 4, 5, 6, and 14, further, a rotating bottle assembly 20 is provided between the fire rack assembly 9 and the wire drawing assembly 10, and the rotating bottle assembly 20 includes a rotating bottle base 201, a turntable 202 with a rotating shaft passing through the top of the rotating bottle base 201; an opening is provided on the rotating bottle base 201 from which the turntable 202 extends; the rotating shaft is connected to the first servo motor 205; a first driving rod 203 is connected to the bottom of the rotating bottle base 201, the first driving rod 203 is connected to the first driving wheel 204, and the driving wheel is connected to the first servo motor 205, and the first servo motor 205 can drive the first driving wheel 204 to rotate, thereby driving the turntable 202 to approach the wire drawing assembly 10, and after the wire drawing is completed, it leaves the wire drawing assembly and returns to its original position. In this embodiment, when the ampoule bottle needs to be drawn, the rotating bottle base 201 is moved toward the wire drawing assembly 10 under the rotation of the first driving wheel 204, and the wire drawing clamp 1003 of the wire drawing assembly 10 is lowered to the bottleneck for wire drawing. At this time, the turntable 202 is driven by the rotating shaft to rotate the ampoule bottle body 360 degrees, which is evenly heated and has higher wire drawing stability.

As shown in FIG4, further, the first driving wheel 204 is provided with a first driving swing arm 906 and a second driving swing arm 907. One side of the first driving swing arm 906 and the second driving swing arm 907 are hinged to each other, and the other side of the first driving swing arm 906 and the second driving swing arm 907 are connected to the first driving wheel 204; the lower side of the first driving rod 203 is connected to the first driving swing arm 906 connection; in this embodiment, the first driving wheel 204 drives the first driving swing arm 906 and the second driving swing arm 907 to swing back and forth, thereby driving the first driving rod 203 to move up and down, thereby realizing the rise or fall of the fire rack assembly 9.

Furthermore, the fire rack assembly 9 includes a nozzle rack 901, a nozzle opening 902 is arranged on the upper side of the nozzle rack 901, a second driving rod 903 is connected to the lower side of the nozzle rack 901, the second driving rod 903 is connected to a second driving wheel 904, the second driving wheel 904 rotates itself to drive the second driving rod 903 to move up and down; the second driving wheel 904 is connected to a second servo motor 905; the rotating bottle assembly 20 is arranged on one side of the nozzle opening 902 of the fire rack assembly 9, the second driving motor drives the nozzle rack 901 to move downward, and can make the nozzle opening 902 align with the neck position of the ampoule bottle arranged on the turntable 202. In this example, two types of nozzle openings 902 with different powers are adopted on the nozzle rack 901, the front nozzle opening 902 is used for preheating, and the rear nozzle opening 902 is used for high-temperature melting, so that the wire drawing assembly 10 can be more efficient in wire drawing.

As shown in Figs. 8 and 9, further, the wire drawing assembly 10 includes a wire drawing frame 1001, the wire drawing frame 1001 is provided with a rotating assembly 1002, the rotating assembly 1002 is provided with a wire drawing clamp 1003, the lower side of the wire drawing frame 1001 is connected to a third driving rod 1004, the third driving rod 1004 is connected to a third driving wheel 1005, the third driving wheel 1005 itself rotates to drive the third driving rod 1004 to rise and fall; the third driving wheel 1005 is connected to a third servo motor 1006; the third servo motor 1006 drives the wire drawing frame 1001 to move up and down. In this embodiment, the wire drawing clamp 1003 is lowered from the open state to the neck of the ampoule and clamps it, and then the melted neck is grabbed upward, and the angle of the wire drawing clamp 1003 is changed by the third rotating rod to turn it to the slag discharge device, and the bottle slag is discharged after the wire drawing clamp 1003 is opened. The rotating bottle assembly 20 rotates the ampoule bottle body moved thereto by 360 degrees through the rotating bottle shaft platforms which are arranged at equal intervals, so that the neck of the ampoule bottle can be heated evenly.

As shown in FIG7 , further, a sealed housing 21 is arranged behind the wire drawing frame 1001, and the sealed housing 21 includes a first sealed container 211 and a second sealed container 212 fixedly connected up and down; the upper section of the third driving rod 1004 is arranged in the first sealed container 211, and the lower section of the third driving rod 1004 is arranged in the second sealed container 212. A first through hole 213 is provided at the junction with the second sealed container 212 for the third driving rod 1004 to pass through; a spring member is provided on the upper sleeve of the third driving rod 1004, and the diameter of the spring member and the cross-sectional area of the upper end of the third driving rod 1004 are greater than the diameter of the through hole; to ensure that after the third driving rod 1004 is pulled downward by force, the third driving rod 1004 can resist the spring member, and the spring member can resist the first through hole 213; the lower edge of the sealed shell 21 resists the top of the working platform 18; and a second through hole is provided on the lower edge for the third driving rod 1004 to pass through, and a sealing O-ring 216 is provided on the second through hole. In this embodiment, since the driving device that drives the wire drawing clamp 1003 to swing and open and close is under the working platform 18, the middle driving rod part will pass through the working platform 18 to connect the clamp and the driving device, and a certain amount of space is required for movement; this will result in the need to open a larger opening at the working platform 18 for the driving rod to pass through; when the traditional ampoule bottle adopts the wire drawing process, it is not necessary to isolate the space of the wire drawing part. In short, the cleanliness requirements for the wire drawing of the ampoule bottle are not high, but the current system also needs to be compatible with the working cleanliness requirements of the syringe bottle (the sterile core area is Class A under a Class B environment); a larger opening in this area cannot meet the cleanliness requirements. This application adds a sealed shell to the driving rod, and uses a sealing O-ring 216 at the junction of the isolation space to further better seal and isolate the running part of the wire drawing component 10 to achieve higher cleanliness requirements.

Furthermore, the rotating assembly 1002 also includes a main support 10021, and a first rotating shaft 10022, a second rotating shaft 10023 and a third rotating shaft 10024 rotatably connected to the main support 10021, the first rotating shaft 10022 and the second rotating shaft 10023 are arranged side by side under the third rotating shaft 10024, and the wire drawing clamp 1003 is composed of a plurality of single-sided components respectively arranged on the first rotating shaft 10022 and the second rotating shaft 10023 facing each other, and the first rotating shaft 10022 and the second rotating shaft 10023 are divided on the same side. The first gear 10025 is meshed with each other and is rotatably connected to the main support 10021. The first rotating shaft 10022 and the second rotating shaft 10023 are rotated to open or close the wire drawing clamp 1003. The third rotating shaft 10024 can flip the rotating assembly 1002 to one side as a whole. The end of the main support 10021 close to the first gear 10025 is embedded with a damping structure. The first gear 10025 end side of the first rotating shaft 10022 is wound with one side of the first steel strand 217, and the other side of the first steel strand is wound with the third driving shaft 10024. The upper part of the moving rod 1004; the end side of the third rotating shaft 10024 is wound with the side of the second steel strand 218, and the end side is the first gear side of the first rotating shaft 10022; the other side of the second steel strand 218 is wound with the upper part of the third driving rod 1004; the lower part of the third driving rod 1004 is connected with the third steel strand 219 and the fourth steel strand 220 between the third driving wheel 1005. In this embodiment, the wire drawing assembly 10 needs to complete three actions. First, it can move up and down in the longitudinal direction, descending from the initial position to the bottle body position; secondly, the clamp needs to be opened and closed so that the clamp can clamp the bottleneck after melting; finally, the entire clamp assembly swings outward and opens the clamp, throws the clamped residual glass into the slag discharge assembly 23, and returns to the initial position, and repeats the above actions. The first rotating shaft 10022 and the second rotating shaft 10023 are used to drive the jaws to open or close, and the meshing first gear structure can make the two rotating shafts move highly synchronously, so that the jaws can open or close more smoothly and are less likely to have problems such as jamming. The third rotating shaft 10024 is arranged above the first rotating shaft 10022 and the second rotating shaft 10023, and is used to drive the entire jaw device to swing outward, so it has a larger diameter than the first rotating shaft 10022 and the second rotating shaft 10023, and can better drive the entire jaw device to swing.

Furthermore, the third driving wheel 1005 faces the third servo motor 1006 and includes a clamping cam 10051, a swing frame cam 10052 and a clamp opening cam 10053 in sequence; the clamping cam 10051 drives the wire drawing frame 1001 to move up and down; the swing frame cam 10052 drives the clamp to swing back and forth by connecting with the fourth steel strand; the clamp opening cam 10053 is connected with the third steel strand 219 to drive the wire drawing clamp 1003 to open or close; the third driving rod 1004 includes a left driving rod 10041 and a right driving rod 10042, the upper side of the left driving rod 10041 is connected to the first steel strand, and the lower side is connected to the third steel strand 219, the upper side of the right driving rod 10042 is connected to the second steel strand, and the lower side is connected to the fourth steel strand 220. In this embodiment, steel wire ropes are respectively connected to the upper and lower sides of the driving rod, and the clamping device and the driving device are respectively linked through the steel wire ropes. Due to their strong flexibility and high hardness, they can be better designed in space, saving space while ensuring the stress requirements of the driving wire drawing assembly 10.

In addition, as mentioned above, the first rotation axis 10022, the second rotation axis 10023 and the third rotation axis The movement mode of the rotating shaft 10024 is different, so the driving wheels and driving rods connected to them are also different. The first steel strand 217, the third steel strand 219, the left driving rod 10041, the first rotating shaft 10022, the second rotating shaft 10023 and the clamp opening cam 10053 are a group of interlocking components; the second steel strand 218, the fourth steel strand 220, the right driving rod 10042, the third rotating shaft 10024 and the swing frame cam 10052 are a group of interlocking components; the wire drawing frame 1001 and the clamping cam 10051 are a group of interlocking components to complete the up and down movement of the upper and lower wire drawing frames 1001.

Furthermore, an "L"-shaped guide plate 221 and a guide wheel 222 arranged between the guide plates 221 are provided in the direction of the steel strands leading to the driving wheel. One side of the guide plate 221 is connected to the lower side of the sealing housing 21, and the other side is connected to the third driving wheel 1005. The third steel strand 219 and the fourth steel strand 220 bypass the guide wheel 222 and are connected to the third driving wheel 1005. Such a configuration can smoothly change the direction of the force and better transmit the driving force.

Furthermore, a retracting rod assembly 223 is provided between the clamping cam 10051 and the wire drawing frame 1001. The retracting rod assembly 223 includes a retracting shell 224, a displacement rod 225 disposed in the retracting shell 224 and movable up and down, and a bearing platform 226 is provided at the upper end of the displacement rod 225. The rod body of the displacement rod 225 relies on the clamping cam 10051, and utilizes the self-rotation of the clamping cam 10051 to drive the displacement rod 225 to move up or down. Thus, three different cams are used through a set of driving wheels to achieve three different motions, complete wire drawing and slag removal, and are multi-purpose, non-interfering, and highly efficient and stable.

As shown in Figures 10 and 11, further, a slag discharge assembly 23 is arranged opposite to the fire rack assembly 9; the slag discharge assembly 23 includes a ground slag discharge channel 231 with an opening on the top, and a sealed bin 232 is connected to the bottom of the ground slag discharge channel 231, and the sealed bin 232 is provided with a movable bottom plate 233, and the default state of the movable bottom plate 233 is tilted open; a bottom plate driving rod 234 is provided on one side of the movable bottom plate 233, and the bottom plate driving rod 234 passes through the side wall of the sealed bin 232 and is connected to the driving cylinder 235, and the driving cylinder 235 is fixedly connected to the limit plate 236; an upright limit plate 236 is welded above the sealed slag box 238; a second slag discharge channel 237 is provided under the movable bottom plate 233, and a sealed slag box 238 is provided at the outlet of the second slag discharge channel 237, and a There is an opening connected to the outlet of the second slag discharge channel 237, and is sealed and connected to the second slag discharge channel 237. A track 239 is laid at the bottom of the slag box, and a slag trolley 240 with rollers is provided on the track 239. The slag trolley 240 is used to receive the residue dropped from the second slag discharge channel 237. A sealed front door 241 is provided at the front side of the slag box, and the sealed front door 241 is matched with a sensor 242. In this embodiment, an optical fiber sensor 242 is used. When the sensor 242 senses that the sealed front door 241 is open, it notifies the control system to drive the cylinder 235 to close the movable bottom plate 233. When the sensor 242 senses that the sealed front door 241 is closed, it restores the movable bottom plate 233 to its original open state. In this embodiment, in order to ensure the cleanliness requirements of the isolation area, the slag discharge system of the ampoule bottle also needs to be improved to improve the cleanliness so that it can adapt to the cleanliness requirements required when the vial passes through the area in the integrated system. Although the working area will not work when the vials pass through, if the slag discharge system is in an open state, it will reduce the dust or residue in this area from entering the isolated working area, thereby reducing the cleanliness of the isolated working area. Therefore, in this embodiment, a slag discharge system is proposed that is in an isolated and sealed state regardless of whether it is working or not. First, when the system is working, the movable bottom plate 233 of the sealed bin 232 is open for the discharge of the calcined residue; when the residue in the slag trolley 240 needs to be emptied, the front door of the slag box is opened, and the movable bottom plate 233 is closed through the sensor, so that the isolated space is always kept in a sealed state to meet the cleanliness requirements of the vials.

As shown in Figs. 12 and 13, further, the slag discharge component 23 is provided with an exhaust component 25, and the exhaust component 25 includes a wind bucket 251, a pneumatic butterfly valve 252 and a heat exhaust channel 255 connected in sequence from bottom to top; the heat exhaust fan 253 and the fan housing 254 arranged outside the heat exhaust fan 253 are arranged on one side of the start butterfly valve. In this embodiment, the exhaust component 25 is arranged on the slag discharge component 23, which can quickly and efficiently dissipate the heat generated by the fire rack component 9 when heating the ampoule bottle, and the heat is absorbed by the heat exhaust fan 253, which effectively ensures that the temperature inside the isolator is within a reasonable range and will not affect the operation of the filling system and the product.

Furthermore, the wind scoop 251 adopts a funnel-shaped structure, and the outlet direction is toward the fire rack assembly 9. The wind scoop 251 concentrates the airflow and increases the flow rate, so that the incoming airflow rotates and passes through the built-in wind ball to enter the heat exhaust channel 255, thereby realizing automatic air intake. The valve body in the pneumatic butterfly valve 252 is constructed to be full The short-distance clamping structure formed by the narrow pipeline space improves the sealing performance of the exhaust component 25, further enhances the sealing performance of the ampoule bottle related process equipment, and has achieved a higher cleanliness requirement.

After the user inputs the bottle type, the sealing process of ampoule bottles and vials is different here. The above-mentioned fire rack assembly 9, bottle rotating assembly 20 and wire drawing assembly 10 are only turned on when the ampoule bottle is filled, and the system will turn on the bottle rotating motor so that when the flame is heated, the bottle body can be heated evenly at 360 degrees. The control system controls the sealing lifting motor and the wire drawing clamp 1003 motor through electrical signals to complete the corresponding actions to seal the ampoule bottle. When the bottle type is a vial, the above will be closed. After the filling is completed, the vial needs to be plugged. After the plugging is completed, the signal collected by the sensor 242 is used to judge the plugging situation through the control system and then judge whether it needs to be discarded.

The function of the stopper feeding system component 12 is as follows: when filling vials, the stopper feeding system component 12 is activated by the instruction given by the filling program issued by the control system, and the filled vials are stoppered by oscillating stoppering; when filling ampoules, the stopper feeding system component 12 does not activate.

The function of the plugging assembly 13 is as follows: when filling a vial, according to the instruction given by the filling program issued by the control system, the plugging assembly 13 absorbs the rubber stopper through vacuum, lifts the bottle through the lifting block on the lifting rod, and presses the rubber stopper into the vial; if an ampoule is filled, the plugging assembly 13 does not operate.

The function of the sampling and rejecting component 14 is to control the rotation of the star wheel with the vacuum suction cup through the command issued by the control system, sample and reject the defective products and samples, and put them into the sampling and rejecting box for subsequent material transfer.

The function of the discharge screw assembly 15 is to arrange the filled cillin/ampoules at equal intervals through the discharge screw and transport them to the ampoule discharge/cillin discharge assembly at a uniform speed.

The functions of the ampoule discharge assembly 16 and the vial discharge assembly 17 are as follows: after filling is completed, the filled ampoule bottles are directly discharged from the ampoule discharge assembly 16 through the action of the discharge star wheel; the filled vials are transported to the downstream through the vial discharge assembly 17 and the mesh belt for capping (water injection) or capping after freeze-drying (powder injection).

Further, a filling control method for an ampoule and a vial: This control method is based on the above Any of the above-mentioned ampoule and vial integrated filling systems, when the container bottle to be filled is an ampoule, the ampoule filling mode is opened through the control system, and the screw parts of the feed screw assembly 2, the gear parts of the feed star wheel assembly 3, the guardrail parts of the bottle protection assembly 6, the gear parts of the inlet plum blossom star wheel 4 and the gear parts of the outlet plum blossom assembly 11 are replaced to be suitable for the operation of the ampoule; in the ampoule filling mode, the control system controls the feed mesh belt assembly 1, the feed screw assembly 2, the feed star wheel assembly 3, the inlet plum blossom star wheel 4, the filling system assembly 7, the needle rack assembly 8, the fire rack assembly 9, the wire drawing assembly 10, the outlet plum blossom assembly 11, the discharge screw assembly 15 and the ampoule outlet The feeding assembly operates; when the container bottle to be filled is a vial, the vial filling mode is turned on by the control system, and the screw parts of the feed screw assembly 2, the gear parts of the feed star wheel assembly 3, the guardrail parts of the bottle protection assembly 6, the gear parts of the inlet plum blossom star wheel 4 and the gear parts of the outlet plum blossom assembly 11 are replaced to be suitable for the operation of the vial; in the ampoule filling mode, the control system controls the feed mesh belt assembly 1, the feed screw assembly 2, the feed star wheel assembly 3, the inlet plum blossom star wheel 4, the filling system assembly 7, the needle holder assembly 8, the outlet plum blossom assembly 11, the stopper feeding system assembly 12, the plug pressing assembly 13, the discharging screw assembly 15 and the vial discharging assembly 17 to operate.

The feeding mesh belt assembly 1 conveys the container bottles to the feeding screw assembly 2, and the conveying direction of the container bottles is changed by the feeding screw assembly 2, and the container bottles are conveyed to the feeding star material assembly one by one. The feeding star wheel assembly 3 conveys the container bottles to the inlet plum blossom star wheel 4 by rotation, and the inlet plum blossom star wheel 4 conveys the container bottles to the filling system assembly 7 and the needle rack assembly 8 for nitrogen filling and medicine filling; the bottle delivery assembly 5 and the bottle protection assembly 6 clamp the container bottles in the groove of the bottle delivery assembly 5, and are protected by the guardrail of the bottle protection assembly 6, and the container bottles are delivered to the relevant process components for processing; finally, the container bottles are conveyed to the corresponding outlets by the discharging screw assembly 15.

The fire rack assembly 9 heats the bottleneck of the ampoule bottle to make it melt, and the wire drawing assembly 10 throws the residue of the ampoule bottle to the slag discharge assembly 23.

The stopper feeding system assembly 12 is a container for storing stopper caps, and the stopper caps are transferred to the upper part of the plug pressing assembly 13 in a rotating manner in the container. When the vial is conveyed to the bottom of the plug pressing assembly 13, the plug pressing assembly 13 is pressed down as a whole to seal the stopper cap at the upper end of the vial.

The above-mentioned ampoule or vial filling process and the equipment involved are similar to the existing ampoule or vial independent filling process and the equipment involved. Therefore, the specific details of the equipment will not be described in detail.

It will be appreciated that the present invention is not limited to the exact construction that has been described above and shown in the drawings, and that various modifications and changes may be made without departing from the scope thereof.

Claims (20)

1. A filling system integrating ampoules and vials, characterized in that it comprises a feed mesh belt assembly, a feed screw assembly, a feed star wheel assembly, an inlet plum blossom star wheel, a needle rack assembly, an outlet plum blossom assembly, a sampling and rejecting assembly, a discharging screw assembly and a control system which are arranged in sequence; a filling system assembly is arranged adjacent to the needle rack assembly; a bottle feeding assembly and a bottle protecting assembly are arranged adjacent to the inlet plum blossom star wheel; a fire rack assembly and a wire drawing assembly are arranged in sequence between the needle rack assembly and the outlet plum blossom assembly; a plug feeding system assembly and a plug pressing assembly are arranged adjacent to the outlet plum blossom assembly; an ampoule discharging assembly and a pen bottle discharging assembly are respectively arranged at the outlet end of the discharging screw assembly; the control system is respectively connected to the feed mesh belt assembly, the feed screw assembly, the filling system assembly, the needle rack assembly, the fire rack assembly, the wire drawing assembly, the plug feeding system assembly, the plug pressing assembly and the discharging screw assembly.
2. According to claim 1, an integrated ampoule and vial filling system is characterized in that it includes a working platform and an isolation wall surrounding the working platform, the isolation wall, the working platform and the ceiling form an isolation space, the operating parts of each component in the filling system are above the working platform, and the drive and power supply parts are arranged below the working platform.
3. According to claim 1, the integrated ampoule and vial filling system is characterized in that the feed mesh belt assembly stores container bottles, the feed mesh belt assembly shrinks the distance between two adjacent container bottles until the bottle bodies are adjacent to each other, and at the same time, the feed mesh belt assembly transports the container bottles input from the upstream process to the feed star wheel assembly.
4. According to claim 3, an integrated ampoule and vial filling system is characterized in that the feed mesh belt assembly includes a first fence, a second fence, a feed mesh belt and an arc-shaped tensioning spring; the first fence, the second fence and the feed screw assembly form a "凵" shape, with their opening direction facing the upstream feed port; a transport mesh belt is also laid flat inside the first fence, the second fence and the feed screw assembly, and its transport direction is perpendicular to the axial direction of the feed screw, and the arc-shaped tensioning spring is vertically arranged on the feed mesh belt, one side is connected to the first fence, and the other side is connected to the second fence.
5. The ampoule and vial integrated filling system according to claim 1 is characterized in that: The needle holder assembly is provided with a servo motor and a transmission screw rod for up and down movements to cooperate with the filling system assembly to perform nitrogen filling and filling actions on the packaging material.
6. The integrated ampoule and vial filling system according to claim 1 is characterized in that the filling system components are connected to the fire rack component and the wire drawing component through a control system.
7. According to claim 6, an integrated ampoule and vial filling system is characterized in that a rotating bottle assembly is further provided between the fire rack assembly and the wire drawing assembly, the rotating bottle assembly comprising a rotating bottle base, a turntable with a rotating shaft passing through the top of the rotating bottle base; an opening is provided on the rotating bottle base from which the turntable extends; the rotating shaft is connected to the first servo motor; a first driving rod is connected to the bottom of the rotating bottle base, the first driving rod is connected to the first driving wheel, the driving wheel is connected to the first servo motor, the first servo motor can drive the first driving wheel to rotate, drive the turntable to approach the wire drawing assembly, and after the wire drawing is completed, it leaves the wire drawing assembly and returns to its original position.
8. According to claim 7, an integrated ampoule and vial filling system is characterized in that the fire rack assembly includes a nozzle rack, a nozzle opening is arranged on the upper side of the nozzle rack, a second driving rod is connected to the lower side of the nozzle rack, the second driving rod is connected to a second driving wheel, and the second driving wheel itself rotates to drive the second driving rod to move up and down; the second driving wheel is connected to a second servo motor; the bottle rotating assembly is arranged on one side of the nozzle opening of the fire rack assembly, and the second driving motor drives the nozzle rack to move downward, and can align the nozzle opening with the neck position of the ampoule arranged on the turntable.
9. According to claim 8, an integrated ampoule and vial filling system is characterized in that a first driving swing arm and a second driving swing arm are provided outside the first driving wheel, one side of the first driving swing arm and the second driving swing arm are hinged to each other, and the other side of the first driving swing arm and the second driving swing arm are connected to the first driving wheel; the lower part of the first driving rod is connected to the first driving swing arm.
10. According to claim 8, the filling system of an ampoule and a vial is characterized in that the wire drawing assembly includes a wire drawing frame, a rotating assembly is provided on the wire drawing frame, a wire drawing clamp is provided on the rotating assembly, the lower side of the wire drawing frame is connected to a third driving rod, and the third driving rod is connected to a third wire drawing clamp. The third driving wheel can drive the third driving rod to move up and down by rotating itself; the third driving wheel is connected to a third servo motor; the third servo motor drives the wire drawing frame to move up and down.
11. According to claim 10, an integrated ampoule and vial filling system is characterized in that a sealed shell is arranged behind the wire drawing frame, and the sealed shell includes a first sealed container and a second sealed container fixedly connected up and down; the upper section of the third drive rod is arranged in the first sealed container, and the lower end of the third drive rod is arranged in the second sealed container, and a first through hole for the third drive rod to pass through is provided at the junction of the first sealed container and the second sealed container; a spring member is provided on the outer sleeve of the upper section of the third drive rod, and the diameter of the spring member and the upper end area of the third drive rod are greater than the diameter of the through hole; the lower edge of the sealed shell is against the top of the working platform; and a second through hole for the third drive rod to pass through is provided on the lower edge, and a sealing O-ring is provided at the junction with the second through hole.
12. According to claim 11, an ampoule and vial integrated filling system is characterized in that the rotating assembly further includes a main support, and a first rotating shaft, a second rotating shaft and a third rotating shaft rotatably connected in the main support, the first rotating shaft and the second rotating shaft are arranged side by side below the third rotating shaft, the wire drawing clamp is composed of a plurality of single-sided components arranged on the first rotating shaft and the second rotating shaft facing each other, the same side of the first rotating shaft and the second rotating shaft are respectively rotatably connected to the main support through mutually meshing first gears, and the wire drawing clamp is opened or closed by rotating the first rotating shaft and the second rotating shaft; the third rotating shaft can flip the rotating assembly as a whole to one side; the end of the main support close to the first gear side is embedded with a damping structure; the first gear end side of the first rotating shaft is wound with one side of the first steel strand, and the other side of the first steel strand is wound above the third driving rod; the end side of the third rotating shaft is wound with one side of the second steel strand, and the other side of the second steel strand is wound with the top of the third driving rod; the third steel strand and the fourth steel strand are connected between the bottom of the third driving rod and the third driving wheel.
13. According to the filling system of an ampoule and a vial as claimed in claim 12, it is characterized in that the third driving wheel is oriented toward the third servo motor and includes a clamping cam, a swing frame cam and a clamp opening cam in sequence. Cam; the clamp cam drives the wire drawing frame to move up and down; the swing frame cam is connected to the fourth steel strand to drive the clamp to swing back and forth; the opening clamp cam is connected to the third steel strand to drive the wire drawing clamp to open or close; the third driving rod includes a left driving rod and a right driving rod, the upper side of the left driving rod is connected to the first steel strand, and the lower side is connected to the third steel strand, the upper side of the right driving rod is connected to the second steel strand, and the lower side is connected to the fourth steel strand.
14. According to claim 13, an integrated ampoule and vial filling system is characterized in that an "L"-shaped guide plate and a guide wheel arranged between the guide plates are provided in the direction of the steel strand leading to the drive wheel, one side of the guide plate is connected to the lower side of the sealing shell, and the other side is connected to the third drive wheel, and the third steel strand and the fourth steel strand bypass the guide wheel and are connected to the third drive wheel.
15. According to the ampoule and vial integrated filling system of claim 14, it is characterized in that a retractable rod assembly is also provided between the clamping cam and the drawing frame, the retractable rod assembly includes a retractable shell, a displacement rod arranged in the retractable shell and movable up and down, a bearing platform is provided at the upper end of the displacement rod, the rod body of the displacement rod relies on the clamping cam, and utilizes the self-rotation of the clamping cam to drive the displacement rod to move upward or downward.
16. A filling system for ampoule and vial as described in claim 15, characterized in that a slag discharge assembly is arranged opposite to the fire rack assembly; the slag discharge assembly comprises a first slag discharge channel with an opening at the top, a sealed bin is connected below the first slag discharge channel, the sealed bin is provided with a movable bottom plate, a bottom plate driving rod is arranged on one side of the movable bottom plate, the bottom plate driving rod passes through the side wall of the sealed bin and is connected to an external driving cylinder, the driving cylinder is fixedly connected to a limit plate; a second slag discharge channel is arranged under the movable bottom plate, a sealed slag box is arranged at the outlet of the second slag discharge channel, an opening communicating with the outlet of the second slag discharge channel is arranged above the slag box, and the opening is airtightly connected to the second slag discharge channel, a track is laid at the bottom of the slag box, a slag trolley with rollers is arranged on the track, the slag trolley is used to receive the residue dropped from the second slag discharge channel, a sealed front door is arranged on the front side of the slag box, and a sensor is matched with the sealed front door. When the sensor senses that the sealed front door is opened, the control system is notified to drive the cylinder to close the movable bottom plate, and when the sensor senses that the sealed front door is opened, the control system is notified to drive the cylinder to close the movable bottom plate. When the sealed front door is closed, the movable bottom plate is restored to its original open state.
17. According to the ampoule and vial integrated filling system of claim 15, it is characterized in that an exhaust assembly is provided on the slag discharge assembly, and the exhaust assembly includes a wind scoop, a pneumatic butterfly valve and a heat exhaust channel connected in sequence from bottom to top; a heat exhaust fan and a fan housing arranged outside the heat exhaust fan are arranged together on one side of the heat exhaust channel.
18. An integrated ampoule and vial filling system according to claim 1, characterized in that the filling system component is connected to the stopper feeding system component and the plug pressing component through a control system.
19. According to the ampoule and vial integrated filling system of claim 1, it is characterized in that the filling system component is connected to the discharge screw assembly through a control system; the discharge screw assembly is respectively connected to the ampoule discharge assembly or the vial discharge assembly.
20. A filling control method for an ampoule and a vial: This control method is based on any one of claims 1 to 19 of the filling system for an ampoule and a vial, and is characterized in that when the container bottle to be filled is an ampoule, the ampoule filling mode is opened by the control system, and the screw member of the feed screw assembly, the gear member of the feed star wheel assembly, the guardrail member of the bottle guard assembly, the gear member of the inlet plum blossom star wheel and the gear member of the outlet plum blossom assembly are replaced to be suitable for the operation of the ampoule; in the ampoule filling mode, the control system controls the operation of the feed mesh belt assembly, the feed screw assembly, the feed star wheel assembly, the inlet plum blossom star wheel, the filling system assembly, the needle rack assembly, the fire rack assembly, the wire drawing assembly, the outlet plum blossom assembly, the discharge screw assembly and the ampoule discharge assembly;

    When the container bottle to be filled is a vial, the vial filling mode is turned on through the control system, and the screw member of the feed screw assembly, the gear member of the feed star wheel assembly, the guardrail member of the bottle guard assembly, the gear member of the inlet plum blossom star wheel and the gear member of the outlet plum blossom assembly are replaced to be suitable for the operation of the vial; in the ampoule filling mode, the control system controls the operation of the feed mesh belt assembly, the feed screw assembly, the feed star wheel assembly, the inlet plum blossom star wheel, the filling system assembly, the needle holder assembly, the outlet plum blossom assembly, the stopper feeding system assembly, the plug pressing assembly, the discharging screw assembly and the vial discharging assembly;

    The feeding mesh belt assembly conveys the container bottles to the feeding screw assembly, changes the conveying direction of the container bottles through the feeding screw assembly, and conveys the container bottles one by one to the feeding star material assembly. The feed star wheel assembly rotates to transport the container bottle to the inlet plum blossom star wheel, and the inlet plum blossom star wheel transports the container bottle to the filling system assembly and the needle rack assembly for nitrogen filling and medicine filling; the bottle delivery assembly and the bottle protection assembly clamp the container bottle in the groove of the bottle delivery assembly, and the guardrail of the bottle protection assembly is used for protection, and the container bottle is delivered to the relevant process assembly for processing; finally, the container bottle is transported to the corresponding outlet by the discharge screw assembly;

    The fire rack assembly heats the bottleneck of the ampoule bottle to melt it, and the wire drawing assembly throws the residue of the ampoule bottle to the slag discharge assembly;

    The stopper feeding system assembly is a container for storing stopper caps, and the stopper caps are transferred to the upper part of the plugging assembly in a rotating manner in the container. When the vial is conveyed to the bottom of the plugging assembly, the plugging assembly is pressed down as a whole to seal the stopper cap at the upper end of the vial.