WO2024135141A1 - 容器保管装置 - Google Patents

容器保管装置 Download PDF

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Publication number
WO2024135141A1
WO2024135141A1 PCT/JP2023/040341 JP2023040341W WO2024135141A1 WO 2024135141 A1 WO2024135141 A1 WO 2024135141A1 JP 2023040341 W JP2023040341 W JP 2023040341W WO 2024135141 A1 WO2024135141 A1 WO 2024135141A1
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WO
WIPO (PCT)
Prior art keywords
container
rack
storage device
containers
container storage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2023/040341
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
康博 小原
俊輔 佐々木
早織 千田
優 七字
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi High Tech Corp
Original Assignee
Hitachi High Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi High Tech Corp filed Critical Hitachi High Tech Corp
Priority to CN202380075456.1A priority Critical patent/CN120129837A/zh
Priority to JP2024565661A priority patent/JPWO2024135141A1/ja
Priority to EP23906512.1A priority patent/EP4641207A1/en
Publication of WO2024135141A1 publication Critical patent/WO2024135141A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/0092—Scheduling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00613—Quality control
    • G01N35/00663—Quality control of consumables
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00435—Refrigerated reagent storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00445—Other cooling arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00613—Quality control
    • G01N35/00663—Quality control of consumables
    • G01N2035/00673—Quality control of consumables of reagents

Definitions

  • the present invention relates to a container storage device.
  • specimens In the field of automated analyzers that perform qualitative and quantitative analysis of samples such as blood and urine (hereinafter referred to as specimens), technology has been disclosed for transferring reagents, specimens, etc. between a storage unit and an analysis processing unit (see Patent Document 1).
  • Patent Document 1 only describes the provision of bottles for storing various solutions such as cleaning solutions, and storage cabinets for storing various reagents, but gives no consideration to the method of storing the containers.
  • the current method of container storage and management for automated analyzers requires the user to retrieve detergent and quality control samples from an external refrigerator each time they are used. Another issue is that the cleaning process and quality control are carried out separately.
  • the object of the present invention is to provide a highly reliable container storage device that simplifies container management.
  • the container storage device of one embodiment of the present invention is connectable to an analysis device that performs sample analysis, and transports containers to and from the analysis device. It includes a container storage section that stores a first container that holds a first liquid used in sample analysis and a second container that holds a second liquid used in the maintenance of the analysis device, and a cooling section that keeps the container storage section cool.
  • the present invention simplifies container management and provides a highly reliable container storage device.
  • FIG. 1 is a diagram showing an example of an automatic analysis system in which a container storage device is connected to an automatic analysis device.
  • FIG. 4 is a diagram showing an example of a main screen displayed on a display unit.
  • FIG. 13 is a diagram showing an example of a container information registration screen.
  • FIG. 13 is a diagram showing an example of a rack range registration screen.
  • FIG. 13 is a diagram showing an example of a screen for registering a group.
  • FIG. 13 is a diagram showing an example of a screen for setting a container removal time.
  • 13 is a flowchart showing a container storage process.
  • 13 is a flowchart showing a container carrying-out process.
  • 13 is a flowchart showing an additional carrying-out process after a container is carried out.
  • This embodiment is an embodiment of a container storage device that can be connected to an analysis device that performs sample analysis and that transports containers between the analysis device and the analysis device, and includes a container storage section that can store multiple first containers that contain a first liquid used in the analysis of the sample and multiple second containers that contain a second liquid used in the maintenance of the analysis device, and a cold storage section that keeps the container storage section cold.
  • “used for the analysis of the sample” in relation to the first liquid also includes the meaning of "used for calibration of the reagent or for quality control of the analysis” or "to perform the analysis correctly.”
  • the first liquid is assumed to be a quality control sample or a standard liquid.
  • the second liquid used for the maintenance of the analysis device is assumed to be a cleaning liquid (including detergent and cleaning water used to clean the analysis device.
  • a cleaning liquid including detergent and cleaning water used to clean the analysis device.
  • this will be mainly referred to as "detergent").
  • the container storage section that can store multiple first and second containers corresponds to a disk 4f including a compartment 4b described later, and the cold storage section corresponds to a cold storage section 4g described later.
  • FIG 1 shows an example of an automatic analysis system in which a container storage device is connected to an automatic analysis device (hereinafter, analysis device).
  • analysis device an automatic analysis device
  • the rack input unit 1 of the automatic analyzer system is an input unit for inputting a rack 18 capable of mounting a plurality of containers 17 into the analyzer 5 and/or 6, and is configured so that an operator can simultaneously mount a plurality of racks 18 and automatically input them one by one.
  • the rack input unit 1 is provided with a rack ID acquisition unit 11 for reading identification information (ID) given in the form of a barcode or IC tag attached to the rack, and a container ID acquisition unit 3 for reading identification information (ID) given in the form of a barcode or IC tag to each container 17, and the identification information is read for each rack 18 and container 17 inserted by the operator and output to the control unit 12.
  • the racks 18 and containers 17 for which the identification information has been read are sequentially sent to the sending and conveying line 9.
  • the containers 17 may be any containers that meet a predetermined standard, and may be sample containers dedicated to the analyzer, test tubes, blood collection containers, etc.
  • the racks 18 hold one or more containers 17 (five in this embodiment), and are conveyed to the sending and conveying line 9 in rack units.
  • control unit 12 of the container storage device 4 is shown as being shared with the control unit of the entire automatic analysis system. However, the control units may be independent for the container storage device 4, the analyzers 5 and 6, and the conveying lines (the forward conveying line 9 and the return conveying line 10).
  • the forward transport line 9 is a path for sending the rack 18 from the rack input unit 1 via the rack storage unit 2, the container storage device 4, the analyzers 5 and 6, etc. to the rack recovery unit 16.
  • the return transport line 10 is a path for returning the rack 18 to the rack recovery unit 16.
  • the rack storage unit 2 temporarily stores the racks 18, and has a rack moving mechanism 2a that carries out the rack 18 inserted from the rack insertion unit 1 to the feed conveying line 9, takes in the rack 18 from the return conveying line 10, and moves the rack 18 to a plurality of storage positions 2b provided in the rack storage unit 2.
  • Information on the storage positions 2b of each rack 18 and the sample information are managed in association with each other, and are stored in the memory unit 13.
  • Container storage device 4 is a device capable of storing containers 17 such as containers containing detergent, containers containing quality control samples, containers containing standard solutions, and/or empty containers, and is an analytical device that performs sample analysis. 5, 6.
  • a transfer line 4e having a function of taking in the rack 18 from the feed conveying line 9 and sending it out to the feed conveying line 9, and a transfer line 4f adjacent to the transfer line 4e and having a function of identifying the rack 18
  • the identification information reading device 4a for reading information, the container ID acquisition unit 4c for reading the identification information of the container 17, the robot arm (hereinafter, the arm) 4d for grasping the container 17, and the compartment 4b for storing the container 17 are provided.
  • a disk 4f that is concentrically arranged or arranged in parallel and can rotate in a horizontal direction, a cold storage section 4g that cools a container 17 stored in a compartment 4b in the disk 4f, and a lid that is located on the top of the cold storage section 4g and has an opening. (not shown) and includes a shutter 4h having a function of opening and closing a lid to insert and remove the container 17 into and from the cooling section 4g. The shutter 4h covers the lid opening during standby and keeps the temperature of the cold storage section 4g constant. Allows access to 4g.
  • the container storage device 4 is shown as including a feed conveying line 9 and a return conveying line 10, but it may be configured not to include conveying lines, and may be configured to be connectable to conveying lines when connecting to other devices.
  • the analysis devices 5 and 6 are, for example, ISE (Ion Selective Electrode) analysis units, which are detachably provided on the feed conveying line 9 and serve to take in the racks 18 from the feed conveying line 9 and to move them to the sampling positions.
  • Sampling lines 5a and 6a each having a function of moving the rack 18 and sending the rack 18 to a feed conveying line 9 or a return line 10, and a reading device for reading identification information of the rack 18 or the container 17 provided in each sampling line 5a and 6a.
  • the analyzer is provided with tubes 5g and 6g for delivering the mixed test solution, ion selective electrodes 5f and 6f for measuring the electrolyte concentration in the mixed test solution, and a computer for controlling the analyzer.
  • the analyzers 5 and 6 may be an analysis section that mixes and reacts the specimen and reagent in a reaction vessel (not shown) mounted on a reaction disk (incubator) and measures the absorbance of the reaction liquid with a photometer to analyze the biochemical components in the specimen, or may be an immunoanalysis section that mixes and reacts the specimen and reagent in a reaction vessel mounted on a reaction disk (incubator) to perform high-sensitivity analysis of trace components in the blood, such as hormones, in the specimen.
  • Control unit 12 controls the necessary parts of each of the analyzers 5 and 6, controls the mechanisms related to the forward conveying line 9 and the return conveying line 10, and executes calculations and controls necessary for various information processing.
  • the control unit 12 is provided with a memory unit 13, and is connected to an operation unit 14 for inputting various data and instructions and a display unit 15 for displaying information on a screen.
  • a built-in hard disk or the like can be used as the memory unit 13.
  • Programs used by the control unit 12 include a program for performing a cleaning process and a control program for performing an analysis process of the sample to be analyzed, as well as a program for performing a process of carrying out detergent, quality control samples, etc. based on a preset time or a container carrying-out rule, and a check process for managing whether or not detergent and quality control samples can be used.
  • Container storage and container removal Container storage is a process of storing a container 17 in advance in the container storage device 4.
  • the container 17, whose sample code has been registered in advance in the storage unit by the user is placed on a rack 18 having a rack ID included in the rack range (range of rack ID) registered in advance by the user, and the rack 18 is placed on the rack input unit 1.
  • the rack 18 placed on the rack input unit 1 is moved to the feed conveying line 9, identified as a rack for the container storage device by the rack ID acquisition unit 11, and transported to the transfer line 4e of the container storage device 4.
  • the container 17 placed on the rack 18 transported to the transfer line 4e is grasped by the arm 4d and moved to the container ID acquisition unit 4c.
  • the identifier attached to the container 17 is read by the container ID acquisition unit 4c, and the container 17 is transferred from the rack 18 to the compartment 4b of the disk 4f using the arm 4d.
  • the transferred container 17 is stored in a cooled state in the cold storage section 4g until an instruction to remove it from the compartment 4b is received.
  • the rack 18 transported to the sampling lines 5a and 6a of the analyzers 5 and 6 is transported to the return transport line 10 and then transported to the rack storage section 2 after the pipettors 5c and 6c access the containers 17.
  • the rack moves from the rack storage section 2 to the transfer line 4e of the container storage device 4, and the arm 4d is used to store the containers 17 in the compartment 4b in the same manner as described above.
  • the container removal is a process of removing the containers 17 stored in the container storage device 4, and is carried out in the reverse order to the container storage process.
  • Container storage and container removal settings are made by displaying registration information screens 200, 300 (see Figures 3 and 4, etc. below) on the display unit 15 under the control of the control unit 12 and operating the operation unit 14.
  • registration and updating of detergent and quality control sample information means setting a removal protocol for the detergent and quality control sample from the container storage device 4, and the container information registration screen 200, rack range setting screen 300, group registration setting screen 500, etc. constitute container removal protocol setting screens.
  • the settings and operations for container removal will be described using an example of removing a quality control sample to be used for quality control after a detergent to be used for device maintenance has been removed from the container storage unit.
  • a transport protocol can be set in a similar manner when it is necessary to remove detergent after removing the quality control sample or standard solution.
  • Main Screen 100 2 is a diagram showing an example of a main screen 100 displayed on the display unit 15.
  • the main screen 100 is provided with an information display area 106 for displaying various information, various instruction buttons 127 to 131 for instructing the operations of the analyzers 5 and 6, and a help button 132 for displaying information to assist the operator in the operation.
  • Information display area 106 is provided with a routine operation tab 101, a reagent tab 102, a calibration tab 103, a quality control tab 104, and a container storage tab 105. By selecting these tabs, the information display area 106 is 2 shows a case where the container storage tab 105 is selected and a container storage setting area 111 for displaying information related to container storage is displayed in the information display area 106.
  • Container storage information display area 106 The container storage information display area 106 is provided with a status tab 107, a setting tab 108, and a carrying-out time tab 109. By selecting these tabs, the desired information can be displayed in the container storage setting area 111. 2 shows a case where the setting tab 108 is selected and information on settings for detergent, quality control samples, and empty containers is displayed in the container storage setting area 111.
  • the container storage setting area 111 displays a disk position column 112, a sample name column 113, a type column 114, a sample code column 115, a lot number column 116, a rack supply method column 117, a remaining amount column 118, an automatic removal column 119, a linked removal column 120, and a usability column 121, which display information (container information) related to each of the registered detergents and quality control samples in a list form, a scroll button 123 for scrolling the display area of this information, a container information registration button 124 for displaying a container information registration screen 200 when registering a new detergent or quality control sample or when checking container information selected with the cursor 122, a container information deletion button 125 for deleting container information selected with the cursor 122, a rack registration button 126 for displaying a rack range setting screen 300, a group registration button 133 for displaying a group registration setting screen 500, and an analysis item registration button 134 for displaying a screen (not shown)
  • the control unit 12 stores in the memory unit 13, etc., as sample status information for registered quality control samples, such as usability indicating whether the sample can be used for measurement, the storage period (OBS) since storage in the container storage device 4, the remaining amount of detergent, the remaining amount of quality control sample, the number of measurements indicating the number of times the sample has been used for measurement, the expiration date, and a container-specific number for identifying different containers in the same lot.
  • the control unit 12 can also display and allow the user to select from a list of alarms to be notified, such as container unregistered, insufficient remaining sample, insufficient empty racks, expired sample expiration date, and expired sample OBS.
  • the main screen 100 is provided with command buttons 127 to 131 for the operator to instruct the operation of the automatic analyzer.
  • the command buttons include a stop button 127 for stopping the automatic analyzer, a sample stop button 128 for stopping sampling, an alarm button 129 for notifying the operator of an abnormality in the apparatus, a print button 130 for instructing printing, and a start button 131 for starting up the automatic analyzer.
  • Container information registration screen 200 Fig. 3 is a diagram showing an example of a container information registration screen, and Fig. 4 is a diagram showing an example of a rack range setting screen, Fig. 3 shows a case where a new container is set, and Fig. 4 shows a case where a rack allocation for temporarily storing containers in the rack storage unit 2 for automatic container removal is set.
  • the container information registration screen 200 has a basic information area 201 for inputting basic information about the container, a container removal information area 202 for inputting information about container removal, a registration/update button 226 for registering a container with the information entered in the information areas 201 and 202, or updating the container information, and returning to the main screen 100, and a cancel button 227 for discarding the information entered in the information areas 202 to 211 and returning to the main screen 100.
  • the basic information area 201 has input fields 202 to 209 for inputting rack supply method 202, sample name 203, type 204, sample code 205, lot number 206, expiration date 207, volume ( ⁇ L) 208, and in-warehouse storage period 209.
  • Input into each input field can be done directly using the input means of the operation unit 14 (e.g., keyboard, pointing device, etc.), or selectively using a pull-down menu, such as type input field 204.
  • the container removal information 202 includes an input field where the user can select whether automatic removal 210 and coordinated removal 211 can be set. Containers selected as "Yes” here can be selected in the group registration described in FIG. 5.
  • the rack range setting screen 300 in FIG. 4 is provided with an area 301 for allocating racks to be manually supplied when transporting from the rack input unit 1 to the analyzers 5 and 6, an area 302 for allocating racks to be automatically supplied by having empty racks waiting in the rack storage unit 2 in advance, a register/update button 326 for registering samples or updating sample information with the content entered in the information areas 301 and 302 and returning to the main screen 100, and a cancel button 327 for discarding the content entered in the information areas 311 to 320 and returning to the main screen 100.
  • the manual supply area 301 is provided with an area 311 for inputting a general sample rack ID start number, an area 312 for inputting a general sample rack ID end number, an area 313 for inputting a standard solution rack ID start number, an area 314 for inputting a standard solution rack ID end number, an area 315 for inputting a quality control sample rack ID start number, an area 316 for inputting a quality control sample rack ID end number, an area 317 for inputting a detergent rack ID start number, and an area 318 for inputting a detergent rack ID end number.
  • the automatic supply area 302 is provided with an area 319 for inputting the container storage device rack ID start number, and an area 320 for inputting the container storage device rack ID end number.
  • FIG. 5 shows an example of a screen for registering a group.
  • Group registration setting screen 500 is a screen for setting the combination of containers to be shipped, and includes an area 501 for selecting a group name, an area 502 for inputting normal shipment conditions, an area 511 for inputting additional shipment conditions 1, an area 512 for inputting additional shipment conditions 2, and an area 503 for inputting linked shipment conditions.
  • the group name can be selected (521), and each area is provided with an input section for specifying the container transfer conditions to the rack according to the number of shipments (522, 528, 534).
  • input fields 523-527, 529-533, 535-539 are provided for specifying which position on the rack (5 positions in this case) the container will be placed on (selected from the containers registered in FIG. 2).
  • an input field 551 is provided for specifying an additional group that will remove containers after containers are transferred from the container storage device to the rack 18 in the group 521 being set.
  • An input field 550 is provided for specifying how many minutes will elapse after all groups have been removed for this linked group to be executed.
  • FIG. 6 shows an example of a screen for setting the container removal time, that is, a screen for setting the container removal time set in the container information registration screen 200 in FIG. 3 and the group registration setting screen 500 in FIG. 5.
  • the removal time tab 109 is selected and a removal target module is selected in the removal target module selection section 152
  • the container storage setting area 111 is provided with a combination ID column 140, combination name column 141, and day of the week columns 142-148 which display registered sample names and group names in a list, and a planned removal time input column 149 at each intersection of the sample name and day of the week columns.
  • the time the analyzers 5 and 6 are in standby, the time the analyzers 5 and 6 are in operation, and the time when maintenance is performed on the analyzers 5 and 6 can be specified.
  • FIG. 7 is a flow chart showing the container storage process.
  • the control unit 12 reads the identification information attached to the rack 18 or each container 17 (step S20) and records the insertion time (step S30).
  • step S40 it is determined whether there is information about a liquid that corresponds to the read identification information (step S40), and if the determination result is No, an alarm is displayed on the display unit 15 (step S41), the rack 18 is transported to the rack recovery unit 16 (step S42), and the process ends.
  • step S40 it is determined whether there is space available to store containers in the container storage device 4 (step S50), and if the determination result is Yes, the container 17 is transported to the transfer line 4e of the container storage device 4 (step S60), the container 17 is removed from the rack 18 on the transfer line by the arm 4d, and the arm 4d moves the container 17 to the container ID acquisition unit 4c, where the container ID is read.
  • the disk 4f then rotates to move an empty compartment 4b to the position of the shutter 4h.
  • the shutter 4h is opened by a motor, and part of the lid is exposed. After the lid is opened, the arm 4d moves from the barcode reading position to the opening while still holding the container, and once it is above the opening, the arm 4d descends while still holding the container 17, storing the container 17 in the compartment 4b (step S70). After storing the container 17, the arm 4d rises and moves to the barcode reading position to enter standby. The shutter 4h then closes, completing the container storage process. Thereafter, the usability information for the liquid information, such as the quality control sample, is recorded as "usable" (step S80), and the process ends.
  • the usability information for the liquid information such as the quality control sample
  • Figure 8 is a flow chart showing the container removal process, and shows a method for removing and transporting the containers 17 stored in the container storage device 4 in Figure 7 from the compartment 4b to the analysis devices 5 and 6.
  • step S100 it is determined whether grouped containers are to be removed. If Yes, a reservation for removal is made for the grouped containers (step S105). If No, it is determined whether an empty transport rack is in the rack storage section 2 or the transfer line 4e (step S110).
  • step S120 it is determined whether there is a usable detergent container (whether a container containing the detergent to be removed is stored (whether a reservation for removal was made but the user forgot to put in the container), whether a container is available but the detergent in it has not expired, etc.) (step S120). If Yes, it is determined whether there is a sufficient amount of detergent remaining (step S130).
  • step S140 it is determined whether the additional removal conditions are met (step S140), and if No, the transfer of containers from compartment 4b is started (step S170), and it is determined whether the coordinated removal conditions are met (step S180), and if No, the rack 18 on which the containers are placed is transported to the analyzer (step S200).
  • the detergent is consumed in the analyzer (step S210), the rack 18 is transported from the analyzer to the container storage device 4 (step S220), the number of times the containers have been removed is recorded in the memory unit (step S230), the containers are transferred from the rack to compartment 4b of the container storage device 4 (step S240), and the process ends.
  • Step S150 it determines whether the additional removal conditions are met, and if Yes, it determines whether the added detergent can be used. If Yes, it determines whether there is a sufficient amount of the added detergent remaining (Step S160), and if Yes, it starts transferring the container. It determines whether the added container can be used (Step S150), and if No, it issues an alarm and ends the process. It determines whether there is a sufficient amount of the added detergent remaining (Step S160), and if No, it issues an alarm and stops the process. It determines whether the coordinated removal conditions are met (Step S180), and if Yes, it executes the coordinated removal step (Step S190).
  • step S300 it is determined whether the coordinated transport is a grouped container removal. If the answer is Yes, a reservation for removal of the grouped containers is made (step S305). If the answer is No, it is determined whether there is an empty rack for transporting the containers (step S310). If the answer is Yes in step S310, it is determined whether there is a usable quality control sample container (whether a container containing the quality control sample to be removed is stored (whether the user has reserved the container but forgotten to put it in), whether there is a container but the quality control sample in it has not expired, etc.) (step S320). If the answer is Yes in step S330, it is determined whether the remaining amount is sufficient (step S330).
  • step S340 it is determined whether the additional transport condition is met. If the answer is No in step S340, a predetermined time is waited for the transfer of the quality control sample container, that is, waiting for the sample removal is performed (step S350). After that, the quality control sample containers are transferred to a rack (step S360), the rack with the containers placed on it is transported to the analyzer (step S370), the quality control samples are consumed in the analyzer (step S380), the rack 18 is transported from the analyzer to the container storage device 4 (step S390), the number of transports is recorded in the memory unit 13 (step S400), and the containers are transferred to the disk 4f (step S410), completing the process.
  • step S305 If the request for coordinated export is for group export, the export reservation for the containers registered in the group is confirmed (step S305). If the answer is No in steps S310, S320, and S330, an alarm is issued and the process ends (step S311).
  • step S340 it is determined whether the additional export conditions are met (step S340), and if the result is Yes, it is determined whether there is a standard solution container registered under the additional export conditions (whether a container containing the standard solution to be removed is stored (whether the user has reserved the container for removal but forgotten to put it in), whether a container is present but the standard solution in it has not expired, etc.) (step S341). If the answer is Yes, it is determined whether the remaining amount of standard solution in the additional container is sufficient (step S342). If the answer is Yes, wait for standard solution to be carried out (step S350). It is determined whether there is a container registered under the additional carrying-out conditions (step S341), and if the answer is No, an alarm is issued and the process is terminated (step S311). It is determined whether the sample in the additional container is sufficient (step S342), and if the answer is No, an alarm is issued and the process is terminated (step S311).
  • the operator registers container information relating to samples to be analyzed, such as detergent, standard solution, and quality control samples, using the operation unit 14 or the like, based on the respective setting screens displayed on the display unit 15 .
  • container information relating to samples to be analyzed, such as detergent, standard solution, and quality control samples, using the operation unit 14 or the like, based on the respective setting screens displayed on the display unit 15 .
  • the container information is registered based on the container information registration screen 200 displayed on the display unit 15.
  • the rack 18 on which the container 17 containing the detergent is placed is placed in the rack insertion unit 1.
  • the rack ID acquisition unit 11 checks the rack ID (verifies that the ID number is 319, 320 for the container storage device in the rack range setting 300) (step S20 in FIG. 7).
  • the container ID acquisition unit 3 reads the specimen identification information (ID) and records the insertion time, and compares it with the specimen information (specimen code) stored in the memory unit 13 (step S30 in FIG. 7).
  • Container information is acquired by the container ID acquisition unit 3, and if the container set on the container information registration screen 200 is in the rack 18 (step S40 in FIG. 7) and the corresponding disk 4f has an empty compartment 4b for storing the container 17 (step S50 in FIG. 7), it is transported to the transfer line 4e of the container storage device 4 (step S60 in FIG. 7). If there is no specimen information that matches the acquired identification information, an alarm is displayed on the display unit 15 (step S41 in FIG. 7), the rack 18 is transported to the rack recovery unit 16 (step S42 in FIG. 7), and the process ends.
  • the arm 4d grasps the container 17 placed on the rack 18 on the transfer line 4e, transports the container 17 from the transfer line to the container ID acquisition unit 4c, reads the sample ID, and compares it with the information 200 in Figure 3.
  • the shutter 4h operates, making it possible to access the compartment 4b from outside.
  • the arm 4d moves from the container ID acquisition unit 4c to the shutter 4h, the container 17 is stored in the compartment 4b, the arm 4d retreats to the barcode reading position, and the shutter 4h closes (step 70 in FIG. 7). Then, the usability information of the specimen information is recorded as "usable" (step S80 in FIG. 7), and the container storage process ends.
  • the check process checks whether the expiration date set in the container management specimen information has been exceeded, whether the remaining amount is below a set value, and the stabilization time after storage, and if all of these determination results are NO, nothing is done. Furthermore, if at least one of the conditions is met, the usability information is changed to "unusable,” an alarm is displayed on the display unit 15 (step S311 in FIG. 9), and the process ends.
  • the process When grouped containers are being removed, the process performs S110 to S130 for each of the corresponding containers (ISE cleaning solution and conditioner in the case of 500 in Figure 5), but if the containers are not grouped, the process checks whether the rack is in the rack storage section 2 or the transfer line 4e (S110 in Figure 9), whether there is a usable detergent container (S120), and whether there is a sufficient amount remaining (excluding the case where an empty container is stored) (S130), and if any of the conditions are not met, an alarm is displayed on the display section 15 and the container removal process is terminated.
  • ISE cleaning solution and conditioner in the case of 500 in Figure 5
  • step S140 If there is a usable sample rack and a container containing detergent, the additional transfer conditions are then checked (step S140). If the additional transfer conditions (511, 512 in FIG. 5) are set and the number of transfers (528, 534 in FIG. 5) is met, it is confirmed that an additional container (529 in FIG. 5) has been registered (step S150) and that there is a remaining amount of additional containers (step S160), the container to be transferred to the rack and the transfer position on the rack (Pos. 1, etc.) are determined, and transfer of the container to the rack is started (step S170).
  • step S180 If the case does not correspond to the coordinated transport (step S180), after all the containers have been transferred, the rack carrying the containers is transported to the analyzer via the transport unit (steps S200 to S240 in FIG. 8). Then, the rack 18 carrying the containers 17 is moved to the sampling lines 5a and 6a of the analyzers 5 and 6 (step S200), and the pipetters 5c and 6c move from the standby position to above the containers 17 and descend to come into contact with the detergent in the containers 17. After coming into contact with the detergent, the pipetters suck up the detergent, rise while holding it in the nozzle, move above the dilution tanks 5d and 6d, and dispense the detergent in the pipetters into the dilution tanks 5d and 6d (step S210).
  • the detergent discharged into the dilution tanks 5d, 6d reaches the electrodes 5f, 6f via the tubes 5g, 6g, and is discarded outside the analyzer via a waste liquid tube (not shown).
  • the rack 18 carrying the containers 17 is transported back to the transfer line 4e via the return transport line 10, where the containers 17 are stored again in the compartment 4b of the disk 4f, the number of times each container has been transported and the number of times each container has been transported in a grouped state are recorded in the memory unit 13, and the unit waits for the next instruction (steps S210 to S240 in FIG. 8).
  • step S180 If it corresponds to coordinated export (step S180), it is determined whether it is grouped container export (step S300), and it is confirmed whether the rack 18 is in the rack storage section 2 or the transfer line 4e (step S310). If there is no available rack, an alarm is displayed and the coordinated export is canceled (step S311). If there is an available rack, it is determined whether the coordinated export request is for only one container or multiple grouped containers, and if there is only one container, the subsequent processing is carried out for that single container, and if there are multiple grouped containers, the subsequent processing (steps S320 to S340) is carried out for multiple containers.
  • step S320 checks whether there are any usable quality control samples (step S320) and whether there is a sufficient amount of them remaining (except when an empty container is stored) (step S330). If any of the conditions are not met, an alarm is displayed on the display unit 15 (step S311) and the container removal process is terminated.
  • step S340 If there is a usable rack 18 and a container containing a quality control sample, the additional transfer conditions are then checked (step S340). If the additional transfer conditions are set and the number of transfers is appropriate, it is confirmed that additional containers have been registered and that there is a remaining amount of additional containers (except when an empty container has been stored), and the container to be transferred to the rack and the transfer position on the rack (Pos. 1, etc.) are determined.
  • the system waits for a preset time to elapse (30 minutes in the example of 550 in FIG. 5). Then, container transfer begins, and steps S360 to S410 are executed, which are the same as steps S170 and S200 to S240 in FIG. 8. Note that when an empty container is transported to the analyzer, the sample is not aspirated from the container 17, and after the sample nozzle is lowered into the empty container 17, water is discharged from the sample nozzle, filling the container 17 with water and immersing the sample nozzle.
  • detergents used in the maintenance of automated analyzers are procured from the equipment manufacturer and stored in a manner specified by the manufacturer (e.g., at room temperature, in a refrigerator, or in a dark room). These detergents are necessary to remove contamination from equipment parts (e.g., pipettes for dispensing, dilution tanks, and flow paths through which samples pass) and to keep the equipment in good condition.
  • equipment parts e.g., pipettes for dispensing, dilution tanks, and flow paths through which samples pass
  • quality control samples to check whether the same analytical results are obtained as before cleaning. If the same analytical results are not obtained, the electrodes and reagents must be recalibrated using standard solutions and managed so that the same analytical results are obtained.
  • the cleaning process takes time (for example, one hour)
  • the quality control sample is consumed only after the cleaning process is completed, which can lead to problems such as the quality control sample becoming concentrated and the enzyme activity in the quality control sample becoming inactive while waiting for the cleaning process to be completed, resulting in inaccurate measurement results.
  • a container containing detergent is stored in a container storage device with a cooling function and connected to an analytical device.
  • the detergent container is removed at a time specified by the user and transported to the analytical device, where the cleaning process is carried out.
  • different cleaning processes can be carried out depending on the number of times the cleaning process is performed.
  • quality control samples can be removed and transported to the analytical device after the cleaning process, making it possible to carry out quality control without causing a decrease in the quality of the quality control samples. This reduces the burden on users for maintenance and quality control, and allows the analytical device to be properly maintained and managed.
  • Container ID acquisition unit for rack insertion unit 1
  • Container storage equipment 4a Identification information reader 4b Compartment 4c (of container management device 4)
  • container ID acquisition unit 4d Arm 4e Transfer line 4f Disc 4g Cooling section 4h Shutter 5,6 Analytical equipment 5c Pipettor 5d Dilution tank 5f Electrode 5g tube 9.
  • Feed conveying line 10 Return conveying line 11 Rack ID Acquisition Section 12 Control section 13 Memory section 14 Operation section 15 Display unit 16 Rack Collection Section 17 Containers 18 LACK.

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PCT/JP2023/040341 2022-12-20 2023-11-09 容器保管装置 Ceased WO2024135141A1 (ja)

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JP2024565661A JPWO2024135141A1 (https=) 2022-12-20 2023-11-09
EP23906512.1A EP4641207A1 (en) 2022-12-20 2023-11-09 Container storage device

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4147596B2 (ja) 1997-06-20 2008-09-10 東洋紡績株式会社 インキュベータおよびそれを備えた分析装置
JP2010107464A (ja) * 2008-10-31 2010-05-13 Sysmex Corp 検体処理システム及び検体保管庫
JP5648116B2 (ja) * 2013-11-15 2015-01-07 株式会社日立ハイテクノロジーズ 検体処理システム
US20180209999A1 (en) * 2015-07-31 2018-07-26 The Catholic University Of Korea Industry-Academic Cooperation Foundation Automatic quality control device of blood cell analyzer
WO2022091790A1 (ja) * 2020-10-30 2022-05-05 株式会社日立ハイテク 自動分析装置および試料保管装置
JP2022135203A (ja) * 2021-03-04 2022-09-15 シスメックス株式会社 検体分析システムの精度管理方法および検体分析システム
WO2022201637A1 (ja) * 2021-03-24 2022-09-29 株式会社日立ハイテク 自動分析装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4147596B2 (ja) 1997-06-20 2008-09-10 東洋紡績株式会社 インキュベータおよびそれを備えた分析装置
JP2010107464A (ja) * 2008-10-31 2010-05-13 Sysmex Corp 検体処理システム及び検体保管庫
JP5648116B2 (ja) * 2013-11-15 2015-01-07 株式会社日立ハイテクノロジーズ 検体処理システム
US20180209999A1 (en) * 2015-07-31 2018-07-26 The Catholic University Of Korea Industry-Academic Cooperation Foundation Automatic quality control device of blood cell analyzer
WO2022091790A1 (ja) * 2020-10-30 2022-05-05 株式会社日立ハイテク 自動分析装置および試料保管装置
JP2022135203A (ja) * 2021-03-04 2022-09-15 シスメックス株式会社 検体分析システムの精度管理方法および検体分析システム
WO2022201637A1 (ja) * 2021-03-24 2022-09-29 株式会社日立ハイテク 自動分析装置

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Title
See also references of EP4641207A1

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