WO2024108649A1

WO2024108649A1 - Traditional chinese medicine composition, arrhythmia treatment patch, and preparation method therefor

Info

Publication number: WO2024108649A1
Application number: PCT/CN2022/136997
Authority: WO
Inventors: 薄雅坤; 王立平
Original assignee: 深圳先进技术研究院
Priority date: 2022-11-24
Filing date: 2022-12-06
Publication date: 2024-05-30
Also published as: CN116173141A

Abstract

A traditional Chinese medicine composition, an arrhythmia treatment patch, and a preparation method therefor. The traditional Chinese medicine composition comprises, by weight ratio, 10-30 parts of Chuanxiong rhizome, 12-40 parts of longstamen onion, 5-23 parts of borneol, 3-25 parts of Sinapis semen, 10-40 parts of lignum Dalbergiae odoriferae, 30-40 parts of Acorus tatarinowii, and 22-28 parts of Buthus martensii Karsch. The preparation method for the patch comprises: mixing and grinding the described components according to the weight ratio into powder to obtain a traditional Chinese medicine composition; mixing 5-12% of fresh ginger juice, 40-60% of honey, and 25-55% of vinegar in percentage by weight to obtain a solvent; and evenly mixing the prepared solvent and the prepared traditional Chinese medicine composition according to a weight ratio of (1.5-2):1 to obtain a treatment ointment; and uniformly dispersing the prepared treatment ointment on a sticky side of a backing sticker to obtain the patch. In the traditional Chinese medicine composition, by means of the synergistic effect of the solvent and the traditional Chinese medicine composition, medicinal power and heat are organically combined, such that the purpose of improving the curative effect of treating arrhythmia is achieved. The method for preparing the treatment patch is simple and has low equipment requirements.

Description

A Chinese medicine composition, arrhythmia treatment patch and preparation method thereof

Technical Field

The present application relates to the field of medical supplies, and in particular to a Chinese medicine composition, an arrhythmia treatment patch and a preparation method thereof.

Background technique

The autonomic nervous system plays an important role in the occurrence and maintenance of atrial fibrillation and ventricular arrhythmias after myocardial infarction. Intervention of the autonomic nervous system to improve the efficacy of atrial fibrillation and ventricular arrhythmias is an effective method. Studies have shown that low-intensity vagus nerve stimulation can intervene in the cardiac autonomic nervous system to prevent and treat atrial fibrillation and ventricular arrhythmias after myocardial infarction.

In related technologies, interventions such as drugs, renal sympathetic denervation or vagus nerve stimulation can effectively reduce ventricular neural remodeling and reduce the risk of arrhythmias, especially fatal arrhythmias. However, antiarrhythmic drugs have a certain effect in treating arrhythmias. Although non-drug treatments can effectively treat ventricular arrhythmias after MI, they are mostly invasive operations with certain risks of complications and recurrence rates. Low-intensity ear edge vagus nerve stimulation is time-dependent and activity-restrictive, and requires patients to have high compliance.

technical problem

Therefore, several common methods for treating arrhythmias in related technologies all have the problems of high requirements for clinical physicians, complicated treatment methods and strict requirements for treatment sites. They also have many requirements for patients and even have side effects such as complications. Therefore, there is still room for improvement.

Technical Solutions

The embodiments of the present application provide a Chinese medicine composition, an arrhythmia treatment patch and a preparation method thereof, so as to solve the problems in the related art of high requirements for clinical treatment physicians, complicated treatment methods and strict requirements for treatment sites.

In a first aspect, a Chinese medicine composition is provided, comprising the following components in weight ratio:

Chuanxiong 10~30, Xiebai 12~40, Borneol 5~23, Mustard seeds 3~25, Dalbergia odorifera 10~40, Acorus calamus 30~40, and Saposhnikovia divaricata 22~28.

Preferably, the particle size of the Chinese medicine composition particles is 20 to 325 meshes.

In a second aspect, a patch for treating arrhythmia is provided, which comprises a solvent, a sticker and the Chinese medicine composition as described above.

Preferably, the solvent comprises the following components in weight percentage:

Fresh ginger juice 5~12%, honey 40~60%, vinegar 25~55%;

The Chinese medicine composition is mixed with a solvent to form a therapeutic ointment, and the therapeutic ointment is dispersed on the sticker.

Preferably, the weight ratio of the solvent to the traditional Chinese medicine composition in the therapeutic ointment is (1.5-2):1.

Preferably, the thickness of the therapeutic ointment is 2-4 mm.

Preferably, the sticker is any one of an infusion sticker, a medical tape, a PE tape, a non-woven tape or a cloth-based tape.

Preferably, the therapeutic ointment is evenly distributed on the sticky side of the sticker.

In a third aspect, a method for preparing an arrhythmia treatment patch is provided, characterized in that the method comprises the following steps:

Mix chuanxiong, xiabai, borneol, mustard seeds, dalbergia odorifera, calamus and whole insects according to the proportion and grind them into powder to obtain a traditional Chinese medicine composition;

Mix 5-12% fresh ginger juice, 40-60% honey and 25-55% vinegar by weight to obtain a solvent;

The prepared solvent and the prepared traditional Chinese medicine composition are mixed evenly in a weight ratio of (1.5-2):1 to obtain a therapeutic ointment;

The prepared therapeutic ointment is evenly dispersed and arranged on the sticky side of the sticker to obtain an application.

Beneficial Effects

The beneficial effects of the technical solution provided by this application include:

(1) The embodiments of the present application provide a Chinese medicine composition which has the characteristics of direct action and wide indications. The Chinese medicine composition patch therapy directly stimulates acupuncture points through drugs and absorbs through the skin, so that the local drug concentration is significantly higher than other parts, and the effect is relatively direct.

(2) The present application provides a patch for treating arrhythmia, which is simple, convenient and easy to promote. The Chinese medicine composition patch therapy is simple to operate, does not require special medical equipment and instruments, is not limited by time and place, and is convenient and easy to use. The preparation formula is mostly composed of many simpler drugs, which is easy to learn and use. Whether it is a doctor, a patient or a family member, most of them can learn and use it at the same time and use it whenever they learn.

(3) The present application provides a patch for treating arrhythmia, which has the characteristics of wide-ranging materials and low-cost medicine. Most of the drugs used in the Chinese medicine combination patch method are common Chinese herbal medicines with low prices, and some of them even come from daily necessities, such as ginger, garlic, and olives. In addition, the method uses a small amount of medicine, which can not only reduce the economic burden of patients, but also save a large amount of medicine.

(4) The present application provides a patch for treating arrhythmia, which has obvious efficacy, is non-toxic and non-invasive. The Chinese medicine composition patch therapy combines the advantages of acupuncture and drug therapy, has significant efficacy, and the drug works by stimulating local acupuncture points, with fewer toxic and side effects. The acupuncture point patch therapy does not require gastrointestinal administration, does not damage the stomach, and is easy to accept. The patch therapy is particularly suitable for patients who are afraid of needles, the elderly, the weak, and those who refuse to take medicine, or for diseases that are not suitable for taking medicine.

BRIEF DESCRIPTION OF THE DRAWINGS

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

FIG1 is a schematic diagram of the stimulation area of the auricular vagus nerve branch provided in an embodiment of the present application.

Embodiments of the present invention

In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

The embodiments of the present application provide a Chinese medicine composition, an arrhythmia treatment patch and a preparation method thereof, which can solve the problems in the related technology of high requirements for clinical physicians, complicated treatment methods and strict requirements for treatment sites.

The TRPV1 receptor is highly expressed in the neuronal cells of the vagus ganglion. The TRPV1 receptor is sensitive to heat stimulation and capsaicin. It is a non-selective ion channel with high permeability to calcium ions and can be activated by capsaicin to cause calcium ion influx. The vagus nerve is the longest and most widely distributed cranial nerve in the human body. Its neuronal cell bodies are located in the vagus ganglion, and its nerve fibers are distributed in the organs of the neck, chest, abdomen, and even pelvic cavity. It must play an important role in the conduction of visceral sensations.

Acupoint application is an ancient traditional Chinese medicine external treatment method. It combines acupuncture, meridians and traditional Chinese medicine theory. It directly applies Chinese medicine to acupoints, which produces micro-area chemical and thermal stimulation on the acupoints through Chinese medicine, and has a dual effect of medicine and acupoints. Through continuous stimulation of acupoints by drugs, it continuously acts on the meridians and internal organs throughout the body to dredge the meridians, harmonize qi and blood, strengthen the body and eliminate evil, regulate the functions of internal organs, balance yin and yang, and achieve the effect of curing and preventing diseases. Modern pharmacological research has proved that acupoint application therapy has the function of regulating the body's immune and endocrine functions, and has the function of enhancing the phagocytic function of the reticuloendothelial system, thereby promoting the dissipation and absorption of inflammation.

Acupoint application is a method of treating diseases externally. Acupoint application therapy is based on the holistic concept of the human body. It combines the viscera and meridians with drugs and uses TCM time medicine to maximize the effectiveness of the two. It is specifically manifested in the following three aspects: one is the role of meridians and acupoints; the second is the efficacy of Chinese medicine; and the third is the time effect of TCM. In addition, modern research has also confirmed that its role is also related to factors such as serum interferon, T lymphocytes, cytokines, lipid metabolism, and free radical levels. Therefore, exogenous non-invasive thermal stimulation of the ear edge vagus nerve branch with Chinese medicine is very helpful for the treatment of rapid arrhythmias.

The embodiment of the present invention provides a traditional Chinese medicine composition, which has a convenient treatment method and good treatment effect. The traditional Chinese medicine composition comprises a traditional Chinese medicine composition, a solvent and a sticker. The traditional Chinese medicine composition comprises the following components in weight ratio:

Chuanxiong 10-30, Xiebai 12-40, Borneolum 5-23, Mustard 3-25, Dalbergia odorifera 10-40, Acorus calamus 30-40, and Scutellaria baicalensis 22-28;

In some embodiments, the particle size of the Chinese medicine composition is 20-325 mesh.

In the first preferred embodiment, the weight ratios of the components of Chuanxiong, Xiebai, Borneolum, Sinapis, Dalbergia odorifera, Acorus calamus, and whole insect contained in the Chinese medicine composition are as follows:

Chuanxiong 10, Xiebai 12, Borneol 8, Mustard seeds 6, Dalbergia odorifera 11, Acorus calamus 30, Whole insect 25.

In the second preferred embodiment, the weight ratios of the components of Chuanxiong, Xiebai, Borneolum, Sinapis, Dalbergia odorifera, Acorus calamus, and whole insect contained in the Chinese medicine composition are as follows:

Chuanxiong 25, Xiebai 30, Borneol 19, Mustard seeds 22, Dalbergia odorifera 31, Acorus calamus 36, and Saposhnikovia divaricata 27.

In the third preferred embodiment, the weight ratios of the components of Chuanxiong, Xiebai, Borneolum, Sinapis, Dalbergia odorifera, Acorus calamus, and whole insect contained in the Chinese medicine composition are as follows:

Chuanxiong 21, Xiebai 27, Borneol 15, Mustard seeds 16, Dalbergia odorifera 26, Acorus calamus 32, and Saposhnikovia divaricata 22.

In one embodiment, 30 g of the Chinese medicine composition is prepared at one time, which is sufficient for a single use by a patient. If batch production is required, the overall weight can be increased in proportion.

The present invention also provides an arrhythmia treatment patch, which comprises the Chinese medicine composition in any of the above embodiments, a solvent and a sticker, wherein the solvent comprises the following components in weight percentage:

Fresh ginger juice 5~12%, honey 40~60%, vinegar 25~55%;

Specifically, the effects of Chuanxiong in the above-mentioned Chinese medicine composition are: promoting blood circulation and removing blood stasis, dispelling wind and relieving pain, and calming. The effects of Xiebai are: promoting yang and dispersing stagnation, promoting qi and removing stagnation. The effects of Borneol are: analgesic and antiseptic, invigorating the mind and refreshing the spirit, clearing away heat and promoting tissue regeneration. The effects of Mustard are: warming the middle and dispersing cold, promoting qi and removing phlegm, and unblocking the meridians and reducing swelling. The effects of Dalbergia odorifera are: removing blood stasis and stopping bleeding, regulating qi and relieving pain. The effects of Acorus calamus are: invigorating the mind and removing phlegm, refreshing the mind and improving intelligence, removing dampness and harmonizing the stomach. The effects of the whole insect are: calming the wind and calming spasms, unblocking the meridians and relieving pain.

In some embodiments, the weight ratio of the solvent to the traditional Chinese medicine composition in the therapeutic ointment is (1.5-2):1.

In some embodiments, the sticker is any one of an infusion sticker, a medical tape, a PE tape, a non-woven tape or a cloth-based tape.

In this embodiment, the method of using the arrhythmia treatment patch is: mix the Chinese medicine composition and the solvent in a ratio of 2:1 to form a paste ointment, take an appropriate amount of the ointment and apply it on the acupuncture points with an infusion patch, each time lasting 4 to 6 hours, once a day, and continuing for 7 days to form a course of treatment.

The solvent in the above-mentioned therapeutic patch can also be directly selected from conventional solvent formulas in the art. However, in order to make the therapeutic patch more effective in treating arrhythmias, that is, to achieve a better synergistic effect between the solvent and the above-mentioned Chinese medicine composition, therefore, as a preferred embodiment of the present invention, the solvent includes the following weight percentage components:

10% fresh ginger juice, 55% honey, 35% vinegar.

The heating composition in the above-mentioned therapeutic patch automatically generates heat during use. The heat generated by it accelerates the tissue regeneration function of the rheumatoid arthritis site. At the same time, the heat of the patch can improve the transdermal permeability of the medicinal ingredients of the traditional Chinese medicine composition. That is, the heating composition can synergistically act with the traditional Chinese medicine composition, organically combining the medicinal power and heat to achieve the purpose of improving the therapeutic effect of rheumatoid arthritis.

In order to make the solvent have a better synergistic effect with the traditional Chinese medicine composition, as a preferred embodiment of the present invention, the weight ratio of the above-mentioned solvent to the traditional Chinese medicine composition is (20-40): (40-80).

As shown in Figure 1, the method of using the arrhythmia treatment patch is: apply the Chinese medicine composition to the acupuncture points in the figure, each time for 4 to 6 hours, once a day, and for 7 days to form a course of treatment. The patch therapy directly stimulates the acupuncture points through drugs, and through transdermal absorption, the local drug concentration is significantly separated from other parts, and the effect is relatively direct. Its indications involve various clinical departments. It can be used simultaneously with internal treatment, and it can also supplement the shortcomings of internal treatment. It can often achieve unexpected and significant effects on many stubborn diseases. At the same time, the Chinese medicine composition therapy is simple to operate, does not require special medical equipment and instruments, is not restricted by time and place, and is convenient and easy to use. The production formula is mostly composed of many simpler drugs, easy to learn and easy to use. Whether it is a doctor, a patient or a family member, most of them can be learned and used at the same time, and can be used as needed.

Accordingly, an embodiment of the present invention further provides a method for preparing an arrhythmia treatment patch, and the process flow of the preparation method comprises the following steps:

S01. Preparation of a Chinese medicine composition: According to the ratio of Chuanxiong, Xiebai, borneol, mustard, dalbergia, Acorus calamus and the whole insects were mixed and ground into powder to obtain a Chinese medicine composition;

S02. Preparation of solvent: Mix 5 to 12% fresh ginger juice, 40 to 60% honey and 25 to 55% vinegar by weight to obtain a solvent;

S03. Prepare the ointment: Mix the prepared solvent and the prepared traditional Chinese medicine composition in a weight ratio of (1.5-2):1 to obtain a therapeutic ointment.

S04. Prepare therapeutic patch: Disperse the prepared ointment on the sticky surface of the infusion patch.

Specifically, the method of grinding each Chinese medicinal material into powder in the above step S01 can be carried out according to the existing method of grinding Chinese medicine. After grinding, the particle size of the Chinese medicine composition is as described above, preferably 200 meshes.

In addition, there is no order between step S01 and step S02, for example, step S01 can be performed first, and then step S02; or step S02 can be performed first, and then step S01. Moreover, when preparing the Chinese medicine composition, the content of each component can be selected from the specific proportions in the above multiple embodiments.

Patching therapy combines the advantages of acupuncture and drug therapy. The prescriptions used are mostly based on clinical experience. After a long period of time and historical verification, the efficacy is remarkable. The drugs work by stimulating local acupuncture points, with fewer toxic and side effects. The combination of Chinese medicines is not administered through the gastrointestinal tract, without the disadvantage of damaging the stomach, and is easy to accept. Patching therapy is particularly suitable for patients who are afraid of needles, the elderly, the weak, and those who refuse to take medicine, or for diseases that are not suitable for taking medicine.

In some embodiments, the Chinese medicine composition is composed of a therapeutic ointment and a sticker. In actual use, the patch may not be limited to the area shown in the accompanying drawings, but may also be applied to acupoints such as Tanzhong, Feishu, Xinshu, and Fengmen.

The above description is only one embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

The above description is only a specific implementation of the present application, so that those skilled in the art can understand or implement the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest range consistent with the principles and novel features applied for herein.

Claims

A Chinese medicine composition, characterized in that the Chinese medicine composition comprises the following components in weight ratio:

Chuanxiong 10~30, Xiebai 12~40, Borneol 5~23, Mustard seeds 3~25, Dalbergia odorifera 10~40, Acorus calamus 30~40, and Saposhnikovia divaricata 22~28.
The Chinese medicine composition according to claim 1 is characterized in that the particle size of the Chinese medicine composition is 20 to 325 meshes.
A patch for treating arrhythmia, characterized by comprising a solvent, a sticker and the traditional Chinese medicine composition according to claim 1 or 2.
The arrhythmia treatment patch according to claim 3, characterized in that:

The solvent includes the following components in weight percentage:

Fresh ginger juice 5~12%, honey 40~60%, vinegar 25~55%;

The Chinese medicine composition is mixed with a solvent to form a therapeutic ointment, and the therapeutic ointment is dispersed on the sticker.
The arrhythmia therapeutic patch according to claim 4 is characterized in that the weight ratio of the solvent to the traditional Chinese medicine composition in the therapeutic ointment is (1.5-2):1.
The arrhythmia treatment patch according to claim 4 is characterized in that the thickness of the therapeutic ointment is 2~4mm.
The arrhythmia treatment patch according to claim 4 is characterized in that the sticker is any one of an infusion patch, a medical tape, a PE tape, a non-woven tape or a cloth-based tape.
The arrhythmia treatment patch according to claim 4 is characterized in that the therapeutic ointment is evenly distributed on the sticky side of the sticker.
A method for preparing an arrhythmia treatment patch, characterized in that it comprises the following steps:

Mix chuanxiong, xibai, borneol, mustard seeds, dalbergia odorifera, calamus and whole insects according to the proportion and grind them into powder to obtain a traditional Chinese medicine composition;

Mix 5-12% fresh ginger juice, 40-60% honey and 25-55% vinegar by weight to obtain a solvent;

The prepared solvent and the prepared traditional Chinese medicine composition are mixed evenly in a weight ratio of (1.5-2):1 to obtain a therapeutic ointment;

The prepared therapeutic ointment is evenly dispersed and arranged on the sticky side of the sticker to obtain an application.