CN1401356A - Chinese medicine patch film and method for producing same - Google Patents
Chinese medicine patch film and method for producing same Download PDFInfo
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- CN1401356A CN1401356A CN 02124073 CN02124073A CN1401356A CN 1401356 A CN1401356 A CN 1401356A CN 02124073 CN02124073 CN 02124073 CN 02124073 A CN02124073 A CN 02124073A CN 1401356 A CN1401356 A CN 1401356A
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Abstract
A Chinese medicine in the form of adhesive film for treating coronary heart disease and angine pectoris is prepared through classifying the Chinese-medicinal materials, extracting, refining, concentrating, mixing, adding borneol powder, stirring, mixing with cellulose solution and glycerine, coating, drying, cutting, and attaching it on non-woven fabric.
Description
Technical field
Patent of the present invention is that domestic and international the first Chinese medicine external, Transdermal absorption, inner disease outer treat prevent and treat the membrane of coronary heart disease.The dosage form novelty, determined curative effect, use simple, convenient, safely, have no side effect.
Background technology
The eighties in 20th century, develop the high-tech product nitro-dur abroad, externally applied transdermal absorbs the treatment angina pectoris, and the nineties, the domestic Western medicine paster of also copying out is used for the treatment of patients with coronary heart disease.
1, this formulation characteristic is: (1) is not taken medicine, is not had an injection, and the medicine externally applied transdermal is absorbed into blood circulation, acts on the pathological changes internal organs at last.(2) medicine is without the destruction and the Degradation of gastrointestinal and liver enzyme.(3) peak-paddy phenomenon of blood drug level behind the no oral or injecting drug use, transdermal administration, blood drug level are steadily and lasting.(4) use simple, convenient, safety.
2, this dosage form major technique and defective: (1) needs to add a large amount of glue as adjuvant.(2) hydrophilic medicament is difficult to Transdermal absorption.Facts have proved in a large number (3) no matter nitroglycerin class medicine is external (Transdermal absorption) or oral, all can produce drug resistance and bad anti-
Should be as headache, dizziness, hypotension, nausea and vomiting etc.
3, up to now, do not work out the new drug of pure natural external, Transdermal absorption, inner disease outer treat treatment angina pectoris both at home and abroad as yet.
Reason is: the necessary content of dispersion of (1) externally applied transdermal absorption type is big, and treatment viscera disease blood drug level height just can reach good result, and the Chinese medicine medicine
Property relatively a little less than.(2) domestic existing Chinese medicine exterior-applied formulation content of dispersion is little, and blood drug level is low, does not reach the effect of treatment viscera disease.(3) mostly the Chinese medicine exterior-applied formulation of selling in the market is a spot of medicine and mixing of macromolecule glues in a large number, be attached on the skin after, medicine
Closely stick together (airtight) with glue and skin, influence the eliminating of skin homergy and secretions, it is uncomfortable that patient feels, is difficult to
Stick for a long time.(4) existing Chinese medicine exterior-applied formulation and production line must adopt temperature drying more than 60 ℃, cause the effective ingredient evaporation and destroy, serious shadow
Ringing curative effect, also is to hinder one of the development of Chinese medicine exterior-applied formulation and reason of inner disease outer treat clinical practice.
4, present, lack the prophylactic of angina pectoris both at home and abroad.
Pad pasting external of the present invention, Transdermal absorption, inner disease outer treat control angina pectoris have been broken through the defective of Chinese medicine exterior-applied formulation, and determined curative effect uses simple, safety, convenience, is domestic and international initiative.
Summary of the invention
1, prescription compatibility of medicines has been broken through the thinking of Chinese medicine conventional formulation: discuss angina pectoris pathogeny and Therapeutic Principle according to the Chinese and western medical scientific principle, and the principle that the synergism that utilizes medicine to cooperatively interact can heighten the effect of a treatment, selected medical material, reasonable compatibility forms.
2, the innovation of technology making and membrane: with selected classification of medicinal material, methods such as difference water, alcohol, percolation, extract the main effective ingredient of medical material, concise, be condensed into thick paste, and the thick paste effective ingredient mixed with the solution (68% medicine, 25% cellulose solution, 7% glycerol) of medical cellulose, be coated with fabric film, drying under the room temperature.Guarantee that pad pasting Chinese medicine effective ingredient is not destroyed, and reaches content of dispersion to greatest extent.Be attached on the breast pareordia skin of a human body left side, medicine is very fast to dissociate out from cellulosic mesh, Transdermal absorption, and blood drug level is high and lasting, reaches the effect of inner disease outer treat.Pad pasting does not stick together with skin, does not influence the eliminating of skin homergy and secretions, and it is comfortable that patient feels, acceptant.
3, be unique angina pectoris prophylactic both at home and abroad so far: the external of this Chinese medicine pad pasting, Transdermal absorption, inner disease outer treat, middle and advanced stage coronary heart disease crowd not only there is therapeutical effect, simultaneously can do prophylactic again, at any time the outbreak of prevention angina pectoris, crowd to latent coronary heart disease people and sub-health state, can prevent, postpone the outbreak and the development of coronary heart disease, bring convenience to the patient in the use.
Coronary heart disease is the human particularly commonly encountered diseases and the frequently-occurring disease of middle-aged and elderly people, is first disease that causes global human death.Along with the senescence of human society, development of global economy and human living standard's raising, sickness rate increases day by day and becomes younger gradually.Mostly be the middle and advanced stage patient to what hospital sought medical advice in the society, have tangible symptom and heart ischemia to sexually revise.This a collection of crowd needs active treatment.In addition some crowd suffers from latent coronary heart disease, non-evident sympton, but in case be subjected to the stimulation of extraneous different reasons, bring out the outbreak of angina pectoris at any time.Also have large quantities of crowds, since highly psychentonia, big, the work fatigue of pressure, dog-eat-dog, add that higher fatty acid in the diet, high protein, high-carbohydrate material increase, and lack physical exertion, be in sub-health state, with advancing age, develop to coronary heart disease day by day.At present, numerous to the medication of middle and advanced stage coronary heart disease human therapy both at home and abroad, but lack effective prophylactic.To the crowd of latent coronary heart disease people and subhealth state, do not pay attention to as yet, more there is not preventive measure.Pad pasting of the present invention has been filled up the blank that domestic and international this class crowd prevents the coronary heart disease medication.
Description of drawings
Fig. 1 is a pad pasting sketch map of the present invention, wherein 1---be meant adhesive-bonded fabric dressing; 2---be meant the medicine film of 0.3 centimetre of 6 cm x, 5 cm x.
The specific embodiment
One, pad pasting prescription of the present invention
1, the design: according to the Chinese and western medical theory to angina pectoris pathogeny and Therapeutic Principle, compatibility has the characteristics that synergism can heighten the effect of a treatment between bound drug, this prescription drug form both had causing resuscitation with aromatic drugs, blood circulation promoting and blood stasis dispelling, arthralgia aggravated by cold pain relieving, the effect that fills blood, have dilating coronary blood vessel, coronary blood flow increasing again, improve the myocardial ischemia-anoxemia equilibrium of supply and demand, reduce the kinds of traditional Chinese medicines of the effect of myocardial oxygen consumption, cardiac function enhancing, mutual compatibility, utilize the synergism between medicine, heighten the effect of a treatment.Therefore, this invention pad pasting inner disease outer treat, determined curative effect, side reaction is few, uses simple, convenient, safety.
2, prescription:
Lignum Santali Albi, the Radix Astragali, Bulbus Allii Macrostemonis, Radix Paeoniae Rubra,
Rhizoma Cyperi, the Radix Angelicae Dahuricae, Lignum Dalbergiae Odoriferae, Rhizoma Acori Graminei,
Radix Puerariae, Flos Chrysanthemi, Borneolum Syntheticum, Caulis Polygoni Multiflori, etc.
Two, film coating process manufacture method of the present invention and pad pasting dosage form are made
Item 1: water is carried: all adopt all medicines such as Rhizoma Acori Graminei, Rhizoma Cyperi, Bulbus Allii Macrostemonis, the Radix Angelicae Dahuricae, Lignum Dalbergiae Odoriferae, Lignum Santali Albis water to put forward the way of distillation.The aqueous solution that adds after the thermal distillation filters, and filtrate adds ethanol after concentrating again, stir well even, leave standstill.Filtrate recycling ethanol also is condensed into thick paste.
Item 2: all medicinal alcohol circumfluence method such as the Radix Astragali, Radix Paeoniae Rubra, Radix Puerariae are extracted each 1 hour 2 times.Merge extractive liquid, filters.Reconcentration becomes thick paste behind the filtrate recycling ethanol.
Item 3: Caulis Polygoni Multiflori etc. are made solution impregnation with ethanol and are carried out percolation after 24 hours according to the percolation under fluid extract and the extractum item.Collect percolate, reconcentration becomes thick paste behind the recovery ethanol.
Item 4: it is standby that Borneolum Syntheticum is milled to attritive powder.
Item 5: mix unguentum and make: item 1 thick paste, 2 thick paste, 3 thick paste and item 4 fine borneol powder are all mixed, stir.
Item 6: Chinese medicine patch film production:
1. get 5 compound, medical cellulose solution, glycerol (the contained ratio of three is respectively 68%, 25%, 7%).Will
The three fully mixes to the bubble complete obiteration.
2. get 6 and mix magmas, be coated with fabric film, under the room temperature behind the dry forming, cut into the small pieces bulk (6cm * 5cm * 0.3cm),
Place on the adhesive-bonded fabric dressing promptly.External application left side breast pareordia.
Claims (3)
1, a kind of Chinese medicine pad pasting of preventing and treating angina pectoris, it is made up of non-woven fabrics adjuvant, medicine film, it is characterized in that described medicine film is made up of extract drugs thick paste, medical fibre cellulose solution and the glycerol of causing resuscitation with aromatic drugs, blood circulation promoting and blood stasis dispelling, arthralgia aggravated by cold pain relieving, the effect that fills blood.
2, the described Chinese medicine pad pasting of claim 1, the medicine of wherein said causing resuscitation with aromatic drugs, blood circulation promoting and blood stasis dispelling, arthralgia aggravated by cold pain relieving, the effect that fills blood is:
Lignum Santali Albi, Rhizoma Cyperi, Lignum Dalbergiae Odoriferae, Bulbus Allii Macrostemonis, the Radix Angelicae Dahuricae, Rhizoma Acori Graminei, the Radix Astragali, Radix Paeoniae Rubra, Borneolum Syntheticum, Radix Puerariae, Flos Chrysanthemi fleece-flower root rattan.
3, the preparation method of claim 1 or 2 described Chinese medicine pad pastings, it comprises:
(1) water is carried: Rhizoma Acori Graminei, Rhizoma Cyperi, Bulbus Allii Macrostemonis, the Radix Angelicae Dahuricae, Lignum Dalbergiae Odoriferae, Flos Chrysanthemi, all medicines of Lignum Santali Albi all adopt water to put forward the way of distillation, and heating is heated up in a steamer
After aqueous solution filter, filtrate adds ethanol after concentrating again, stirs, leaves standstill, filtrate recycling ethanol also is condensed into thick
Cream;
(2) Radix Astragali, Radix Paeoniae Rubra, Radix Puerariae extract 2 times with ethanol refluxing process, and each 1 hour, merge extractive liquid.Filter, filtrate is reclaimed
Reconcentration becomes thick paste behind the ethanol;
(3) Caulis Polygoni Multiflori carries out percolation with alcohol dipping after 24 hours, collects percolation solution, and reconcentration becomes thick paste behind the recovery ethanol;
(4) it is standby Borneolum Syntheticum to be milled to attritive powder;
(5) above-mentioned thick paste and fine borneol powder are all mixed, stir;
(6) get 68% compound, 25% medical fibre cellulose solution, 7% glycerol, the three is mixed to the bubble complete obiteration;
(7) get the mixing thick paste liquid of step (6), coating pharmacy film behind the dry forming, cuts into 5 centimetres of 6 cm x under the room temperature
* 0.3 centimetre small pieces bulk places on the non-woven fabrics adjuvant, promptly.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 02124073 CN1401356A (en) | 2002-06-18 | 2002-06-18 | Chinese medicine patch film and method for producing same |
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CN 02124073 CN1401356A (en) | 2002-06-18 | 2002-06-18 | Chinese medicine patch film and method for producing same |
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CN1401356A true CN1401356A (en) | 2003-03-12 |
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CN 02124073 Pending CN1401356A (en) | 2002-06-18 | 2002-06-18 | Chinese medicine patch film and method for producing same |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103041270A (en) * | 2013-01-25 | 2013-04-17 | 周建华 | Externally used traditional Chinese medicine capable of relieving angina |
CN104784627A (en) * | 2015-02-06 | 2015-07-22 | 肖琼 | Traditional Chinese medicine externally used film agent used for treatment surgical open or closed injury and preparation method thereof |
-
2002
- 2002-06-18 CN CN 02124073 patent/CN1401356A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103041270A (en) * | 2013-01-25 | 2013-04-17 | 周建华 | Externally used traditional Chinese medicine capable of relieving angina |
CN104784627A (en) * | 2015-02-06 | 2015-07-22 | 肖琼 | Traditional Chinese medicine externally used film agent used for treatment surgical open or closed injury and preparation method thereof |
CN104784627B (en) * | 2015-02-06 | 2018-05-22 | 肖琼 | It is a kind of to be used to treat Chinese medicine external film of surgery opening or closed injury and preparation method thereof |
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