CN116173141A - Traditional Chinese medicine composition, arrhythmia treatment application and preparation method thereof - Google Patents
Traditional Chinese medicine composition, arrhythmia treatment application and preparation method thereof Download PDFInfo
- Publication number
- CN116173141A CN116173141A CN202211482727.9A CN202211482727A CN116173141A CN 116173141 A CN116173141 A CN 116173141A CN 202211482727 A CN202211482727 A CN 202211482727A CN 116173141 A CN116173141 A CN 116173141A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- medicine composition
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 81
- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 206010003119 arrhythmia Diseases 0.000 title claims abstract description 25
- 230000006793 arrhythmia Effects 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 29
- 239000002674 ointment Substances 0.000 claims abstract description 23
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 16
- 238000002156 mixing Methods 0.000 claims abstract description 12
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 11
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 9
- 235000008397 ginger Nutrition 0.000 claims abstract description 9
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 241000304531 Allium macrostemon Species 0.000 claims abstract description 8
- 229940116229 borneol Drugs 0.000 claims abstract description 8
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 8
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 8
- 235000012907 honey Nutrition 0.000 claims abstract description 8
- 235000021419 vinegar Nutrition 0.000 claims abstract description 8
- 239000000052 vinegar Substances 0.000 claims abstract description 8
- 239000002023 wood Substances 0.000 claims abstract description 8
- 241000239226 Scorpiones Species 0.000 claims abstract description 7
- 238000000227 grinding Methods 0.000 claims abstract description 7
- 235000019508 mustard seed Nutrition 0.000 claims abstract description 7
- 244000086363 Pterocarpus indicus Species 0.000 claims abstract description 6
- 235000009984 Pterocarpus indicus Nutrition 0.000 claims abstract description 6
- 239000000853 adhesive Substances 0.000 claims abstract description 5
- 230000001070 adhesive effect Effects 0.000 claims abstract description 5
- 239000000843 powder Substances 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 17
- 241000234314 Zingiber Species 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 5
- 241000212322 Levisticum officinale Species 0.000 claims description 4
- 239000001645 levisticum officinale Substances 0.000 claims description 4
- 241000522620 Scorpio Species 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 238000001802 infusion Methods 0.000 claims description 3
- 239000009490 scorpio Substances 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 20
- 241000112528 Ligusticum striatum Species 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 16
- 238000002560 therapeutic procedure Methods 0.000 description 12
- 238000001467 acupuncture Methods 0.000 description 8
- 239000002390 adhesive tape Substances 0.000 description 8
- 210000001186 vagus nerve Anatomy 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 5
- 206010047281 Ventricular arrhythmia Diseases 0.000 description 4
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 210000001835 viscera Anatomy 0.000 description 4
- 206010003658 Atrial Fibrillation Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- 108091006146 Channels Proteins 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 108010025083 TRPV1 receptor Proteins 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 210000000467 autonomic pathway Anatomy 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 229960002504 capsaicin Drugs 0.000 description 2
- 235000017663 capsaicin Nutrition 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 244000138993 panchioli Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 201000003068 rheumatic fever Diseases 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 240000002234 Allium sativum Species 0.000 description 1
- 241000219198 Brassica Species 0.000 description 1
- 235000003351 Brassica cretica Nutrition 0.000 description 1
- 235000003343 Brassica rupestris Nutrition 0.000 description 1
- 206010050337 Cerumen impaction Diseases 0.000 description 1
- 206010008748 Chorea Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 206010067671 Disease complication Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- -1 T lymphocytes Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003416 antiarrhythmic agent Substances 0.000 description 1
- 210000003403 autonomic nervous system Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 210000002939 cerumen Anatomy 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 208000012601 choreatic disease Diseases 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 230000007383 nerve stimulation Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000024121 nodulation Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000003730 sympathetic denervation Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 230000001550 time effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000001515 vagal effect Effects 0.000 description 1
- 230000007384 vagal nerve stimulation Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Insects & Arthropods (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The application relates to a traditional Chinese medicine composition, arrhythmia treatment application and a preparation method thereof. The traditional Chinese medicine composition comprises, by weight, 10-30 parts of ligusticum wallichii, 12-40 parts of allium macrostemon, 5-23 parts of borneol, 3-25 parts of mustard seed, 10-40 parts of rosewood heart wood, 30-40 parts of rhizoma acori graminei and 22-28 parts of scorpion. The preparation method of the application comprises mixing the above components in weight ratio, and grinding into powder to obtain Chinese medicinal composition; mixing 5-12% of fresh ginger juice, 40-60% of honey and 25-55% of vinegar according to weight percentage to obtain a solvent; uniformly mixing the prepared solvent and the prepared traditional Chinese medicine composition according to the weight ratio of (1.5-2): 1 to obtain a therapeutic ointment; and uniformly dispersing the prepared therapeutic ointment on one sticky side of the adhesive paper to obtain the application. The traditional Chinese medicine composition organically combines the efficacy of the medicine and the heat through the synergistic effect of the solvent and the traditional Chinese medicine composition, thereby achieving the purpose of improving the curative effect of treating arrhythmia.
Description
Technical Field
The application relates to the field of medical supplies, in particular to a traditional Chinese medicine composition, arrhythmia treatment application and a preparation method thereof.
Background
The autonomic nervous system plays an important role in the occurrence and maintenance of atrial fibrillation and ventricular arrhythmia after myocardial infarction, and intervention of autonomic nerves to improve the efficacy of atrial fibrillation and ventricular arrhythmia is an effective method. Studies show that the low-intensity vagus nerve stimulation can interfere with the cardiac autonomic nerve to achieve the effect of preventing and treating atrial fibrillation and ventricular arrhythmia after myocardial infarction.
In the related art, the intervention of medicines, renal sympathetic denervation or vagal nerve stimulation and the like can effectively reduce the nerve reconstruction of ventricles and reduce the occurrence risk of arrhythmia, especially lethal arrhythmia. However, antiarrhythmic drugs have a certain effect of treating arrhythmia, and non-drug treatment can effectively treat ventricular arrhythmia after MI, but is often an invasive procedure, and has a certain risk of complication occurrence and recurrence rate; whereas low intensity earwax vagal stimulation is time dependent and activity limiting, requiring high patient compliance.
Therefore, several methods for treating arrhythmia, which are common in the related art, have the problems of high requirements on clinicians, complicated treatment methods and strict requirements on treatment sites, and have more requirements on patients, even have side effects such as disease complications, and therefore, there is still room for improvement.
Disclosure of Invention
The embodiment of the application provides a traditional Chinese medicine composition, arrhythmia treatment application and a preparation method thereof, so as to solve the problems of higher requirements on clinic therapists, complicated treatment methods and strict requirements on treatment places in the related technologies.
In a first aspect, a traditional Chinese medicine composition is provided, wherein the traditional Chinese medicine composition comprises the following components in parts by weight:
10 to 30 parts of szechuan lovage rhizome, 12 to 40 parts of allium macrostemon, 5 to 23 parts of borneol, 3 to 25 parts of mustard seed, 10 to 40 parts of rosewood heart wood, 30 to 40 parts of grassleaf sweelflag rhizome and 22 to 28 parts of scorpion.
Preferably, the particle size of the traditional Chinese medicine composition particles is 20-325 meshes.
In a second aspect, there is provided an arrhythmia treatment application comprising a solvent, a decal and a Chinese medicinal composition as hereinbefore described.
Preferably, the solvent comprises the following components in percentage by weight:
5-12% of fresh ginger juice, 40-60% of honey and 25-55% of vinegar;
the traditional Chinese medicine composition is mixed with a solvent to form a treatment ointment, and the treatment ointment is dispersed on the decal.
Preferably, the weight ratio of the solvent to the Chinese medicinal composition in the therapeutic ointment is (1.5-2): 1.
Preferably, the thickness of the therapeutic ointment is 2-4 mm.
Preferably, the sticker is any one of transfusion sticker, medical adhesive tape, PE adhesive tape, non-woven fabric adhesive tape or cloth-based adhesive tape.
Preferably, the therapeutic ointment is uniformly distributed on the adhesive side of the sticker.
In a third aspect, a method for preparing an arrhythmia treatment application is provided, which is characterized by comprising the following steps:
mixing rhizoma Ligustici Chuanxiong, bulbus Allii Macrostemi, borneolum Syntheticum, semen Brassicae Junceae, lignum Dalbergiae Odoriferae, rhizoma Acori Graminei and Scorpio, and grinding into powder to obtain Chinese medicinal composition;
mixing 5-12% of fresh ginger juice, 40-60% of honey and 25-55% of vinegar according to weight percentage to obtain a solvent;
uniformly mixing the prepared solvent and the prepared traditional Chinese medicine composition according to the weight ratio of (1.5-2): 1 to obtain a therapeutic ointment;
and uniformly dispersing the prepared therapeutic ointment on one sticky side of the adhesive paper to obtain the application.
The beneficial effects that technical scheme that this application provided brought include:
(1) The embodiment of the application provides a traditional Chinese medicine composition, which has the characteristics of direct action and wide application, and the traditional Chinese medicine composition is applied to directly stimulate acupuncture points through medicines, and the local medicine concentration is obviously separated from other parts through transdermal absorption, so that the action is relatively direct.
(2) The embodiment of the application provides an arrhythmia treatment application, which has the characteristics of simplicity, convenience and easiness in popularization, and the traditional Chinese medicine composition application therapy is simple to operate, does not need special medical equipment and instruments, is not limited by time and place, and is convenient and easy to implement. The preparation formula is composed of a plurality of simpler medicines, is easy to learn and use, and can be used simultaneously with study regardless of doctors, patients or families.
(3) The application embodiment provides an arrhythmia treatment application, which has the characteristics of wide material sources and low cost, and most of the medicines used in the traditional Chinese medicine composition application method are common Chinese herbal medicines, so that the application is low in cost, and even some application is from smart living products such as ginger, garlic, forsteria and the like. The method has small dosage, can reduce the economic burden of patients and can save a large amount of medicinal materials.
(4) The application embodiment provides the arrhythmia treatment application, which has the characteristics of obvious efficacy, no toxicity and no wound, the traditional Chinese medicine composition application therapy is long in acupuncture and drug treatment, the curative effect is obvious, the drug plays a role by stimulating local acupuncture points, the toxic and side effects are less, the acupuncture point application therapy is not administered through stomach and intestine, the defect of damaging stomach is overcome, and the application is easy to accept. The patch therapy is especially suitable for patients who are afraid of needles, are old and young and weak, are not forced to take medicines or are unsuitable for taking medicines.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic view of an auricular vagus nerve branch stimulation area according to an embodiment of the present application.
Detailed Description
For the purposes of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present application based on the embodiments herein.
The embodiment of the application provides a traditional Chinese medicine composition, arrhythmia treatment application and a preparation method thereof, which can solve the problems of higher requirements on clinical therapists, complicated treatment methods and strict requirements on treatment places in the related technologies.
Neuronal cell TRPV1 receptors on the vagus nerve node are highly expressed. TRPV1 receptors are sensitive to thermal stimuli and capsaicin, a non-selective ion channel with high permeability to calcium ions, and can be activated by capsaicin to cause calcium ion influx. The vagus nerve is used as the brain nerve with the longest stroke and the widest distribution range in the human body, the neuron cell body of the vagus nerve is positioned in the vagus nerve node, and the nerve fiber is distributed in the organs of the neck, the chest and the abdominal cavity, even the organs of the pelvic cavity, and plays an important role in the transmission process of the internal organ feeling.
The acupoint application chocolate method is an external-depletion method of ancient Chinese traditional medicine in China, combines the acupuncture, meridian and Chinese medicine theory, directly applies the Chinese medicine to the acupoint, and generates micro-area chemical and thermal stimulation to the acupoint by the Chinese medicine, thereby having the dual functions of medicine and acupoint. The medicine continuously stimulates the acupoints and continuously acts on the whole viscera to dredge the channels and collaterals, harmonize qi and blood, strengthen body resistance and eliminate pathogenic factors, regulate viscera functions, balance yin and yang, and achieve the effects of curing and preventing diseases. Modern pharmacological research proves that the acupoint application therapy has the functions of regulating organism immunity and endocrine, and enhancing reticuloendothelial system phagocytosis, thereby promoting inflammation dissipation and absorption.
The acupoint application is a method for treating the chorea externally. The acupoint application therapy is based on the concept of human body, and combines viscera, channels and collaterals with medicines, so that the acupoint application therapy and the medicine therapy achieve maximum effect by utilizing traditional Chinese medicine time medicine. The following three aspects are specifically shown; first, the meridian points act; secondly, the drug effect of the traditional Chinese medicine; thirdly, the time effect of traditional Chinese medicine. In addition, modern researches have also confirmed that the effects of the compounds are also related to factors such as serum interferon, T lymphocytes, cytokines, lipid metabolism, free radical level and the like. Thus, exogenously administered traditional Chinese medicine thermal stimulation of the noninvasive auricular vagus nerve branch is helpful for the treatment of tachyarrhythmias.
The embodiment of the invention provides a traditional Chinese medicine composition, which has the advantages of convenient treatment method and good treatment effect, and comprises the traditional Chinese medicine composition, a solvent and a sticker, wherein the traditional Chinese medicine composition comprises the following components in parts by weight:
10 to 30 parts of szechuan lovage rhizome, 12 to 40 parts of allium macrostemon, 5 to 23 parts of borneol, 3 to 25 parts of mustard seed, 10 to 40 parts of rosewood heart wood, 30 to 40 parts of grassleaf sweelflag rhizome and 22 to 28 parts of scorpion;
in some embodiments, the particle size of the traditional Chinese medicine composition is 20-325 mesh.
In a first preferred embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight:
10 parts of szechuan lovage rhizome, 12 parts of allium macrostemon, 8 parts of borneol, 6 parts of mustard seed, 11 parts of rosewood heart wood, 30 parts of grassleaf sweelflag rhizome and 25 parts of scorpion.
In a second preferred embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight:
25 parts of ligusticum wallichii, 30 parts of allium macrostemon, 19 parts of borneol, 22 parts of mustard seed, 31 parts of dalbergia wood, 36 parts of rhizoma acori graminei and 27 parts of scorpion.
In a third preferred embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight:
21 parts of ligusticum wallichii, 27 parts of allium macrostemon, 15 parts of borneol, 16 parts of mustard seed, 26 parts of dalbergia wood, 32 parts of rhizoma acori graminei and 22 parts of scorpion.
In one embodiment, 30g of the traditional Chinese medicine composition is prepared at a time, so that the traditional Chinese medicine composition can be used for one patient at a time, and the whole weight can be increased in equal proportion if mass production is required.
The invention also provides an arrhythmia treatment application, which comprises the traditional Chinese medicine composition, a solvent and a sticker in any embodiment, wherein the solvent comprises the following components in percentage by weight:
5-12% of fresh ginger juice, 40-60% of honey and 25-55% of vinegar;
specifically, the efficacy of the ligusticum wallichii in the traditional Chinese medicine composition is as follows: promoting blood circulation, dispelling blood stasis, dispelling pathogenic wind, relieving pain, and tranquilizing. Allium macrostemon has the efficacy of: activate yang, dissipate nodulation, promote qi circulation and remove stagnation. Borneol efficacy: pain relieving, antiseptic, resuscitation inducing, refreshing, heat clearing away, and granulation promoting. Efficacy of mustard: warming middle-jiao to dispel cold, promoting qi to remove phlegm, dredging collaterals and relieving swelling. The effect of the rosewood heart wood is as follows: remove blood stasis, stop bleeding, regulate qi and alleviate pain. Rhizoma Acori Graminei has effects of: inducing resuscitation, eliminating phlegm, refreshing mind, improving intelligence, eliminating dampness, and regulating stomach. Total worm efficacy: wind-extinguishing and spasm-relieving, vein-relaxing and pain-relieving.
In some embodiments, the weight ratio of the solvent to the Chinese medicinal composition in the therapeutic ointment is (1.5-2): 1.
In some embodiments, the sticker is any one of an infusion sticker, a medical adhesive tape, a PE adhesive tape, a non-woven adhesive tape, or a cloth-based adhesive tape.
In this embodiment, the application method of the arrhythmia treatment application is as follows: the traditional Chinese medicine composition and the solvent are mixed according to the following ratio of 2:1 are mixed into paste ointment, a proper amount of ointment is taken and applied to the acupuncture points by using infusion plaster, each time lasts for 4-6 hours, 1 time per day lasts for 7 days, and a treatment course is formed.
The solvents used in the above-described therapeutic applications may also be selected directly from solvent formulations conventional in the art. However, in order to make the curative effect of the therapeutic application for treating arrhythmia more remarkable, that is, to make the solvent and the above-mentioned Chinese medicinal composition exert better synergistic effect, as a preferred embodiment of the present invention, the solvent comprises the following components in percentage by weight:
10% of fresh ginger juice, 55% of honey and 35% of vinegar.
The heating composition in the treatment application automatically heats in use, and the generated heat accelerates the tissue regeneration function of the rheumatic arthritis part and simultaneously improves the transdermal permeability of the medicinal components of the traditional Chinese medicine composition through the applied heat, namely the heating composition can be synergistic with the traditional Chinese medicine composition, and the efficacy and the heat are organically combined together so as to achieve the aim of improving the curative effect of treating the rheumatic arthritis.
In order to make the synergistic effect of the solvent and the traditional Chinese medicine composition better, the preferred embodiment of the invention comprises the solvent and the traditional Chinese medicine composition with the weight ratio of (20-40) to (40-80).
As shown in fig. 1, the arrhythmia treatment application is used by the following method: the traditional Chinese medicine composition is applied to acupoints in the figure for 4-6 hours each time, 1 time a day for 7 days to form a treatment course. The application therapy directly stimulates the acupoints by the medicine, and the local medicine concentration is obviously separated from other parts by transdermal absorption, so that the effect is relatively direct. The indications relate to clinical departments, can be used together with internal treatment, can supplement the deficiency of internal treatment and can obtain unexpected obvious effects on a plurality of chronic diseases. Meanwhile, the traditional Chinese medicine composition is simple in treatment operation, does not need special medical equipment and instruments, is not limited by time and place, and is convenient and easy to implement. The preparation formula is composed of a plurality of simpler medicines, is easy to learn and use, and can be used simultaneously with study regardless of doctors, patients or families.
Correspondingly, the embodiment of the invention also provides a preparation method of the arrhythmia treatment application, which comprises the following steps:
s01, preparing a traditional Chinese medicine composition: mixing rhizoma Ligustici Chuanxiong, bulbus Allii Macrostemi, borneolum Syntheticum, semen Brassicae Junceae, lignum Dalbergiae Odoriferae, rhizoma Acori Graminei and Scorpio, and grinding into powder to obtain Chinese medicinal composition;
s02, preparing a solvent: mixing 5-12% of fresh ginger juice, 40-60% of honey and 25-55% of vinegar according to weight percentage to obtain a solvent;
s03, preparing ointment: mixing the prepared solvent with the prepared Chinese medicinal composition (1.5-2) at weight ratio of 1 to obtain therapeutic ointment.
S04, preparing a treatment application: the prepared ointment is dispersed and arranged on the sticky surface of the transfusion patch.
Specifically, the grinding of the traditional Chinese medicine materials in step S01 may be performed according to the existing grinding method of traditional Chinese medicine materials. After the grinding treatment, the particle size of the Chinese medicinal composition is preferably 200 mesh as described above.
In addition, the step S01 and the step S02 are not sequential, for example, the step S01 may be performed first, and then the step S02 may be performed; step S02 may be performed first, and then step S01 may be performed. And the contents of the above components in the preparation of the Chinese medicinal composition can be selected from the specific proportions in the above examples.
The application therapy is long in acupuncture and drug treatment, the compatibility of the used medicines is mostly from clinical experience, long years and history verification prove that the curative effect is remarkable, the drugs exert effect by stimulating local acupuncture points, the toxic and side effects are less, the traditional Chinese medicine composition therapy is not administered through stomach and intestine, the defect of damaging stomach is avoided, and the traditional Chinese medicine composition is easy to accept. The patch therapy is especially suitable for patients who are afraid of needles, are old and young and weak, are not forced to take medicines or are unsuitable for taking medicines.
In some embodiments, the Chinese medicinal composition comprises therapeutic ointment and patch, and in practical use, the patch can be applied to acupoints such as SHANZHONG, FEISHU, XINSHU, and TIONO.
The above embodiments are only examples of the present invention, and the present invention is not limited to the above embodiments, but is intended to be limited to the following modifications, equivalents, and improvements made within the spirit and principles of the present invention.
The foregoing is merely a specific embodiment of the application to enable one skilled in the art to understand or practice the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. The traditional Chinese medicine composition is characterized by comprising the following components in parts by weight:
10 to 30 parts of szechuan lovage rhizome, 12 to 40 parts of allium macrostemon, 5 to 23 parts of borneol, 3 to 25 parts of mustard seed, 10 to 40 parts of rosewood heart wood, 30 to 40 parts of grassleaf sweelflag rhizome and 22 to 28 parts of scorpion.
2. The traditional Chinese medicine composition according to claim 1, wherein the particle size of the traditional Chinese medicine composition is 20-325 meshes.
3. An arrhythmia treatment application comprising a solvent, a sticker and the traditional Chinese medicine composition of claim 1 or 2.
4. The arrhythmia treatment application of claim 3, wherein,
the solvent comprises the following components in percentage by weight:
5-12% of fresh ginger juice, 40-60% of honey and 25-55% of vinegar;
the traditional Chinese medicine composition is mixed with a solvent to form a treatment ointment, and the treatment ointment is dispersed on the decal.
5. The application according to claim 4, wherein the weight ratio of the solvent to the Chinese medicinal composition in the therapeutic ointment is (1.5-2): 1.
6. The application of claim 4, wherein the therapeutic ointment has a thickness of 2-4 mm.
7. The application according to claim 4, wherein the patch is any one of an infusion patch, a medical tape, a PE tape, a nonwoven tape, or a cloth-based tape.
8. The arrhythmia treatment applicator of claim 4 wherein said treatment ointment is evenly distributed on the adhesive side of said decal.
9. A method for preparing an arrhythmia treatment application, which is characterized by comprising the following steps:
mixing rhizoma Ligustici Chuanxiong, bulbus Allii Macrostemi, borneolum Syntheticum, semen Brassicae Junceae, lignum Dalbergiae Odoriferae, rhizoma Acori Graminei and Scorpio, and grinding into powder to obtain Chinese medicinal composition;
mixing 5-12% of fresh ginger juice, 40-60% of honey and 25-55% of vinegar according to weight percentage to obtain a solvent;
uniformly mixing the prepared solvent and the prepared traditional Chinese medicine composition according to the weight ratio of (1.5-2): 1 to obtain a therapeutic ointment;
and uniformly dispersing the prepared therapeutic ointment on one sticky side of the adhesive paper to obtain the application.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211482727.9A CN116173141A (en) | 2022-11-24 | 2022-11-24 | Traditional Chinese medicine composition, arrhythmia treatment application and preparation method thereof |
| PCT/CN2022/136997 WO2024108649A1 (en) | 2022-11-24 | 2022-12-06 | Traditional chinese medicine composition, arrhythmia treatment patch, and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211482727.9A CN116173141A (en) | 2022-11-24 | 2022-11-24 | Traditional Chinese medicine composition, arrhythmia treatment application and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116173141A true CN116173141A (en) | 2023-05-30 |
Family
ID=86443081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211482727.9A Pending CN116173141A (en) | 2022-11-24 | 2022-11-24 | Traditional Chinese medicine composition, arrhythmia treatment application and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN116173141A (en) |
| WO (1) | WO2024108649A1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1517122A (en) * | 2003-10-28 | 2004-08-04 | 温先敏 | Medicine for treating coronary heart disease and its preparation method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1401356A (en) * | 2002-06-18 | 2003-03-12 | 马德林 | Chinese medicine patch film and method for producing same |
| CN1262299C (en) * | 2002-10-21 | 2006-07-05 | 马德林 | Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris and its preparing method |
| CN103251891A (en) * | 2013-05-24 | 2013-08-21 | 王海燕 | Chinese medicinal external-application ointment for treating qi-stagnation and blood stasis type unstable angina |
| CN104906355A (en) * | 2015-07-09 | 2015-09-16 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine combination for arrhythmia treatment and production method thereof |
-
2022
- 2022-11-24 CN CN202211482727.9A patent/CN116173141A/en active Pending
- 2022-12-06 WO PCT/CN2022/136997 patent/WO2024108649A1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1517122A (en) * | 2003-10-28 | 2004-08-04 | 温先敏 | Medicine for treating coronary heart disease and its preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 王忠良;刘敏;梁田;张寒梅;陈立侠;梅发光;张庆;卢磊;周丽;黄秀;王如侠;: "心脉通贴散穴位贴敷联合西药治疗冠心病不稳定型心绞痛40例临床观察", 中医杂志, no. 11, pages 952 - 955 * |
| 郭盈盈;常丽;: "穴位贴敷配合中医护理方案对心衰患者症状改善的效果观察", 湖南中医杂志, no. 04, pages 125 - 127 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024108649A1 (en) | 2024-05-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100982716B1 (en) | Aromatherapy patch | |
| CN107050118B (en) | Traditional Chinese medicine plaster for treating wind-cold-dampness arthralgia and preparation method thereof | |
| CN108175795A (en) | A kind of plaster | |
| CN115737704B (en) | She mud moxibustion composition for relaxing tendons and activating collaterals | |
| CN109700856A (en) | A kind of Chinese medicine external prescription relieved pain with promoting blood circulation and removing obstruction in channels, relaxing muscles and tendons | |
| CN115381912A (en) | External traditional Chinese medicine compound preparation for reducing cancer pain and preparation method thereof | |
| CN116173141A (en) | Traditional Chinese medicine composition, arrhythmia treatment application and preparation method thereof | |
| CN111773262A (en) | Acupuncture point combination method for treating cold and acupuncture point patch used cooperatively | |
| CN1076628A (en) | " Yu ' er " plaster for multiple purposes | |
| CN100998660B (en) | Traditional Chinese medicine plaster for treating vertebral artery type cervical spondylosis and its preparing method | |
| CN107929368A (en) | A kind of Chinese medicine composition and its preparation for treating myoneural pain, pain caused by cancer | |
| CN219835854U (en) | Pressing needle for medical plaster | |
| CN109010549A (en) | Synthetism expelling wind and activating blood flow pain relieving ointment and preparation method thereof | |
| CN1049829C (en) | Magnetic medicinal plaster for assuaging pain of person suffering from cancer | |
| CN102579978B (en) | External traditional Chinese medicine composition for treating scapulohumeral periarthritis | |
| CN115040574B (en) | Traditional Chinese medicine composition and traditional Chinese medicine preparation for treating thyroid nodule and preparation method thereof | |
| CN105920164A (en) | Postoperative wound pain relieving medicine patch | |
| CN102343081A (en) | Moxibustion tool of pure Chinese medicinal preparation for treating bone aching and pure Chinese medicinal preparation for treating bone aching | |
| CN112263622A (en) | Yao medicine and lycopodium clavatum foot bath agent and preparation method thereof | |
| CN112190648A (en) | Yao medicine dampness-clearing foot bath agent and preparation method thereof | |
| CN111035749A (en) | Traditional Chinese medicine mud film for mud moxibustion and preparation method thereof | |
| CN105168973A (en) | Traditional Chinese medicine for treating cervical spondylosis and lumbar spondylosis | |
| CN114984170A (en) | Traditional Chinese medicine composition for treating lumbocrural pain and preparation method and application thereof | |
| CN116327741A (en) | Traditional Chinese medicine harmonizing cold compress patch | |
| CN112316074A (en) | Yao medicine Shujing foot bath agent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |