WO2024087868A1 - 一体式取样密封试剂盒 - Google Patents

一体式取样密封试剂盒 Download PDF

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Publication number
WO2024087868A1
WO2024087868A1 PCT/CN2023/115411 CN2023115411W WO2024087868A1 WO 2024087868 A1 WO2024087868 A1 WO 2024087868A1 CN 2023115411 W CN2023115411 W CN 2023115411W WO 2024087868 A1 WO2024087868 A1 WO 2024087868A1
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WO
WIPO (PCT)
Prior art keywords
reagent bottle
piston cap
sealing
kit
bearing cavity
Prior art date
Application number
PCT/CN2023/115411
Other languages
English (en)
French (fr)
Inventor
郝书顺
郝栋
Original Assignee
石家庄禾柏生物技术股份有限公司
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Application filed by 石家庄禾柏生物技术股份有限公司 filed Critical 石家庄禾柏生物技术股份有限公司
Publication of WO2024087868A1 publication Critical patent/WO2024087868A1/zh

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/047—Additional chamber, reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips

Definitions

  • the invention belongs to the technical field of reagent detection, and in particular relates to an integrated sampling and sealing reagent kit.
  • the test kit is a box used to hold chemical reagents for testing chemical components, drug residues, virus types, etc.
  • the sampling needle on the test kit pierces the test kit, it will pierce the aluminum film sewn on the test reagent bottle, but the aluminum film is usually sealed on the bottle mouth of the reagent bottle.
  • the test kit contacts the test reagent bottle, the aluminum film is sandwiched between the contact surfaces of the two, and the sealing of the contact part between the test kit and the test reagent bottle will be poor, which will cause the escaping gas to float randomly.
  • the reagent is easy to leak and pollute the environment.
  • the embodiment of the present invention provides an integrated sampling sealing reagent kit, which aims to solve the problem of poor sealing and easy leakage of reagents.
  • the technical solution adopted by the present invention is: to provide an integrated sampling and sealing reagent kit, including: a detection box, which is provided with a detection test strip inside; a sampling needle, which is arranged at the first end of the reagent kit, including a main body and a guide groove arranged on the main body, and the guide groove is arranged along the length direction of the main body; a piston cap, which has a bearing cavity, and a sealing structure is provided at the opening of the bearing cavity, and the piston cap is sealed and connected to the first end of the detection box through the sealing structure; and a reagent bottle, which is located in the bearing cavity and is used to hold the detection reagent, and an aluminum film is provided at the bottle mouth of the reagent bottle, and the bottle mouth of the reagent bottle is lower than the opening of the piston cap.
  • a fixing structure is provided on the inner wall of the bearing cavity, and the reagent bottle is clamped inside the piston cap through the fixing structure.
  • the fixing structure is a plurality of grooves arranged inside the bearing cavity, and fixing blocks are evenly annularly fixed on the outer wall of the reagent bottle body. After the reagent bottle is installed, the fixing blocks abut against the inside of the grooves.
  • a plurality of auxiliary ribs are further provided on the interior of the bearing cavity, and the auxiliary ribs are all provided along the depth direction of the piston cap.
  • the plurality of auxiliary ribs are annularly provided on the inner wall of the bearing cavity, and are spaced apart from each other between two adjacent auxiliary ribs.
  • the grooves correspond one-to-one to the auxiliary ribs and are all located on the sides of the auxiliary ribs.
  • a guiding slope is provided at one end of the auxiliary rib close to the mouth of the piston cap, and at least three auxiliary ribs are provided.
  • a positioning protrusion is further provided at the other end of the auxiliary rib.
  • the positioning protrusion is located on the side of the auxiliary rib and extends toward the center of the bearing cavity. The plurality of positioning protrusions are used to position the bottom of the reagent bottle.
  • a positioning cylinder cooperating with the positioning protrusion is further provided at the bottom of the reagent bottle.
  • the sealing structure includes a plug pin arranged on the end surface of the detection box, a snap-in groove arranged at the mouth of the piston cap, and a silicone gasket arranged between the detection box and the piston cap, the end of the plug pin is snap-fitted into the snap-in groove, and the plug pin passes through the silicone gasket.
  • a spherical portion is provided at the end of the plug pin, the diameter of the spherical portion is larger than the maximum diameter of the plug pin, and a snap-in protrusion is also provided at the end of the snap-in groove, and the distance between the two snap-in protrusions is smaller than the diameter of the spherical portion.
  • the beneficial effect of the integrated sampling and sealing kit provided by the present invention is that: compared with the prior art, a piston cap is provided, and the piston cap has a bearing cavity, and the reagent bottle is fixed in the bearing cavity.
  • the bottle mouth of the reagent bottle is lower than the opening of the piston cap, and a sealing structure is provided for connecting the detection box and the piston cap, which solves the problem of poor sealing of the contact part between the detection kit and the detection reagent bottle, avoids the problem of gas escape and random dispersion and easy leakage of reagents, protects the experimenters, and avoids environmental damage.
  • FIG1 is a schematic diagram of the structure of an integrated sampling and sealing kit provided in an embodiment of the present invention.
  • FIG2 is a schematic diagram of a partial enlarged structure of point A in FIG1 ;
  • FIG3 is a schematic diagram of the piston cap structure of the integrated sampling and sealing kit provided in an embodiment of the present invention.
  • FIG4 is a schematic diagram of the structure of a reagent bottle of an integrated sampling and sealing kit provided in an embodiment of the present invention
  • FIG5 is a schematic diagram of the installation structure of the piston cap and the reagent bottle of the integrated sampling and sealing kit provided in an embodiment of the present invention
  • Reagent bottle 41. fixing block; 42. positioning cylinder.
  • the integrated sampling and sealing reagent kit includes a test box 10, a sampling needle 20, a piston cap 30 and a reagent bottle 40.
  • the test box 10 is provided with a test strip inside.
  • the sampling needle 20 is arranged at the first end of the reagent kit, including a main body 21 and a guide groove 22 arranged on the main body 21, and the guide groove 22 is arranged along the length direction of the main body 21.
  • the piston cap 30 has a bearing cavity, and a sealing structure 31 is provided at the opening of the bearing cavity. The piston cap 30 is sealed and connected to the first end of the test box 10 through the sealing structure 31.
  • the reagent bottle 40 is located in the bearing cavity and is used to hold the detection reagent.
  • An aluminum film is provided at the bottle mouth of the reagent bottle 40 for closure, and the bottle mouth of the reagent bottle 40 is lower than the opening of the piston cap 30.
  • the integrated sampling and sealing kit provided in the present embodiment is provided with a piston cap 30, and the piston cap 30 has a bearing cavity, and a reagent bottle 40 is fixed in the bearing cavity.
  • the mouth of the reagent bottle 40 is lower than the opening of the piston cap 30, and a sealing structure 31 is provided for connecting the detection box 10 and the piston cap 30, which solves the problem of poor sealing of the contact part between the detection kit and the detection reagent bottle 40, avoids the problem of gas escaping and drifting randomly and the easy leakage of reagents, protects the experimenters, and avoids environmental damage.
  • the piston cap 30 may adopt a structure as shown in FIG3 and FIG5.
  • a fixing structure 32 is provided on the inner wall of the bearing cavity, and the reagent bottle 40 is clamped inside the piston cap 30 through the fixing structure 32.
  • the fixing structure 32 forms a fixing position inside the piston cap 30, which is used to fix the position of the reagent bottle 40 in the piston cap 30, fix the reagent bottle 40 in the middle position of the piston cap 30, and make the sampling needle 20 accurately enter the reagent bottle 40, strengthen the matching relationship, and have good practicality.
  • the above-mentioned fixing structure 32 can adopt the structure shown in Figures 3 and 5.
  • the fixing structure 32 is a plurality of grooves 321 arranged inside the bearing cavity, and a fixing block 41 is evenly and annularly fixed on the outer wall of the reagent bottle 40. After the reagent bottle 40 is installed, the fixing block 41 abuts against the inside of the groove 321.
  • the groove 321 can also be arranged along the depth direction of the bottle body, corresponding one-to-one with the fixing block 41 on the outer wall of the reagent bottle 40, and is used to locate the position of the reagent bottle 40 in the bearing cavity, with a simple structure and convenient installation.
  • the above-mentioned bearing cavity can adopt the structure shown in Figures 3 and 5.
  • a plurality of auxiliary ribs 322 are also arranged inside the bearing cavity, and the auxiliary ribs 322 are arranged along the depth direction of the piston cap 30.
  • the plurality of auxiliary ribs 322 are arranged in an annular manner on the inner wall of the bearing cavity, and two adjacent auxiliary ribs 322 are arranged at intervals, and the grooves 321 correspond to the auxiliary ribs 322 one by one and are all located on the side of the auxiliary ribs 322.
  • the auxiliary ribs 322 can reduce the wall thickness of the piston cap 30 while completing the positioning, reduce the cost, and reduce the weight of the integrated sampling and sealing reagent kit, which has good practicality.
  • the auxiliary rib 322 may adopt a structure as shown in FIG3 and FIG5.
  • the auxiliary rib 322 is provided with a guide slope at one end close to the mouth of the piston cap 30, and the auxiliary rib 322 is provided with at least three.
  • the guide slope is used to provide guidance for the installation of the reagent bottle 40, facilitating alignment and installation, and the auxiliary rib 322 is provided with at least three to provide positioning for the installation of the reagent bottle 40.
  • the auxiliary rib 322 may adopt a structure as shown in FIG3 and FIG5.
  • a positioning protrusion 33 is further provided at the other end of the auxiliary rib 322.
  • the positioning protrusion 33 is located on the side of the auxiliary rib 322 and extends toward the center of the bearing cavity.
  • the plurality of positioning protrusions 33 are used to position the bottom of the reagent bottle 40.
  • the number of positioning protrusions 33 is the same as that of the auxiliary rib 322, and they correspond to the auxiliary rib 322 one by one. They are connected at the bottom end of the piston cap 30 to form a positioning group, which is used to connect the reagent bottle 40 so that the reagent bottle 40 cannot rotate in the piston cap 30.
  • the structure is simple and the processing is convenient.
  • the reagent bottle 40 may adopt a structure as shown in Figures 4 and 5.
  • the bottom of the reagent bottle 40 is also provided with a positioning cylinder 42 that cooperates with the positioning protrusion 33.
  • the positioning cylinder 42 is a limiting opening at the bottom of the reagent bottle 40, which is used to be plugged into the positioning protrusion 33 to achieve fixation, and the assembly method is simple and practical.
  • the sealing structure 31 can adopt the structure shown in Figures 1 to 3 and 5.
  • the sealing structure 31 includes a plug pin 311 arranged on the end surface of the detection box 10, a clamping groove 312 arranged at the mouth of the piston cap 30, and a silicone gasket 313 arranged between the detection box 10 and the piston cap 30.
  • the end of the plug pin 311 is clamped in the clamping groove 312, and the plug pin 311 penetrates the silicone gasket.
  • the plug pin 311 is evenly arranged on the end surface of the detection box 10 in an annular manner, and corresponds to the clamping groove 312 evenly arranged at the mouth of the piston cap 30 in an annular manner.
  • the plug pin 311 and the clamping groove 312 can be arranged in multiples, or they can be a plug ring and a clamping groove 312. Two silicone gaskets 313 with different diameters and parallel to each other are sleeved on the plug ring to achieve sealing, with a simple structure and good sealing performance.
  • the sealing structure 31 can adopt the structure shown in Figures 1 to 3 and 5.
  • the end of the plug pin 311 is provided with a spherical portion, the diameter of the spherical portion is larger than the maximum diameter of the plug pin 311, and the end of the clamping groove 312 is also provided with a clamping protrusion, and the distance between the two clamping protrusions is smaller than the diameter of the spherical portion.
  • the plug pin 311 and the clamping groove 312 are both made of plastic, have a certain elasticity, can achieve a certain degree of elastic deformation, are easy to manufacture, and have low cost.
  • the integrated sampling and sealing reagent kit includes a test box 10, a sampling needle 20, a piston cap 30 and a reagent bottle 40.
  • the test box 10 is provided with a test strip inside.
  • the sampling needle 20 is arranged at the first end of the reagent kit, including a main body 21 and a guide groove 22 arranged on the main body 21, and the guide groove 22 is arranged along the length direction of the main body 21.
  • the piston cap 30 has a bearing cavity, and a sealing structure 31 is provided at the opening of the bearing cavity. The piston cap 30 is sealed and connected to the first end of the test box 10 through the sealing structure 31.
  • the reagent bottle 40 is located in the bearing cavity and is used to hold the detection reagent.
  • An aluminum film is provided at the bottle mouth of the reagent bottle 40 for closure, and the bottle mouth of the reagent bottle 40 is lower than the opening of the piston cap 30.
  • the integrated sampling and sealing kit provided in the present embodiment is provided with a piston cap 30, and the piston cap 30 has a bearing cavity, and a reagent bottle 40 is fixed in the bearing cavity.
  • the mouth of the reagent bottle 40 is lower than the opening of the piston cap 30, and a sealing structure 31 is provided for connecting the detection box 10 and the piston cap 30, which solves the problem of poor sealing of the contact part between the detection kit and the detection reagent bottle 40, avoids the problem of gas escaping and drifting randomly and the easy leakage of reagents, protects the experimenters, and avoids environmental damage.
  • the piston cap 30 may adopt a structure as shown in FIG3 and FIG5.
  • a fixing structure 32 is provided on the inner wall of the bearing cavity, and the reagent bottle 40 is clamped inside the piston cap 30 through the fixing structure 32.
  • the fixing structure 32 forms a fixing position inside the piston cap 30, which is used to fix the position of the reagent bottle 40 in the piston cap 30, fix the reagent bottle 40 in the middle position of the piston cap 30, and make the sampling needle 20 accurately enter the reagent bottle 40, strengthen the matching relationship, and have good practicality.
  • the above-mentioned fixing structure 32 can adopt the structure shown in Figures 3 and 5.
  • the fixing structure 32 is a plurality of grooves 321 arranged inside the bearing cavity, and a fixing block 41 is evenly and annularly fixed on the outer wall of the reagent bottle 40. After the reagent bottle 40 is installed, the fixing block 41 abuts against the inside of the groove 321.
  • the groove 321 can also be arranged along the depth direction of the bottle body, corresponding one-to-one with the fixing block 41 on the outer wall of the reagent bottle 40, and is used to locate the position of the reagent bottle 40 in the bearing cavity, with a simple structure and convenient installation.
  • the above-mentioned bearing cavity can adopt the structure shown in Figures 3 and 5.
  • a plurality of auxiliary ribs 322 are also arranged inside the bearing cavity, and the auxiliary ribs 322 are arranged along the depth direction of the piston cap 30.
  • the plurality of auxiliary ribs 322 are arranged in an annular manner on the inner wall of the bearing cavity, and two adjacent auxiliary ribs 322 are arranged at intervals, and the grooves 321 correspond to the auxiliary ribs 322 one by one and are all located on the side of the auxiliary ribs 322.
  • the auxiliary ribs 322 can reduce the wall thickness of the piston cap 30 while completing the positioning, reduce the cost, and reduce the weight of the integrated sampling and sealing reagent kit, which has good practicality.
  • the auxiliary rib 322 may adopt a structure as shown in FIG3 and FIG5.
  • the auxiliary rib 322 is provided with a guide slope at one end close to the mouth of the piston cap 30, and the auxiliary rib 322 is provided with at least three.
  • the guide slope is used to provide guidance for the installation of the reagent bottle 40, facilitating alignment and installation, and the auxiliary rib 322 is provided with at least three to provide positioning for the installation of the reagent bottle 40.
  • the auxiliary rib 322 can adopt the structure shown in Figures 3 and 5.
  • the other end of the auxiliary rib 322 is also provided with a positioning protrusion 33, which is located on the side of the auxiliary rib 322 and extends toward the center of the bearing cavity.
  • the plurality of positioning protrusions 33 are used to position the bottom of the reagent bottle 40.
  • the number of positioning protrusions 33 is the same as that of the auxiliary ribs 322, which correspond to the auxiliary ribs 322 one by one, and are connected at the bottom end of the piston cap 30 to form a positioning group, which is used to connect the reagent bottle 40 so that the reagent bottle 40 cannot rotate in the piston cap 30.
  • the structure is simple and the processing is convenient.
  • the reagent bottle 40 may adopt a structure as shown in Figures 4 and 5.
  • the bottom of the reagent bottle 40 is also provided with a positioning cylinder 42 that cooperates with the positioning protrusion 33.
  • the positioning cylinder 42 is a limiting opening at the bottom of the reagent bottle 40, which is used to be plugged into the positioning protrusion 33 to achieve fixation, and the assembly method is simple and practical.
  • the sealing structure 31 can adopt the structure shown in Figures 1 to 3 and 5.
  • the sealing structure 31 includes a plug pin 311 arranged on the end surface of the detection box 10, a clamping groove 312 arranged at the mouth of the piston cap 30, and a silicone gasket 313 arranged between the detection box 10 and the piston cap 30.
  • the end of the plug pin 311 is clamped in the clamping groove 312, and the plug pin 311 penetrates the silicone gasket.
  • the plug pin 311 is evenly arranged on the end surface of the detection box 10 in an annular manner, and corresponds to the clamping groove 312 evenly arranged at the mouth of the piston cap 30 in an annular manner.
  • the plug pin 311 and the clamping groove 312 can be arranged in multiples, or they can be a plug ring and a clamping groove 312. Two silicone gaskets 313 with different diameters and parallel to each other are sleeved on the plug ring to achieve sealing, with a simple structure and good sealing performance.
  • the sealing structure 31 can adopt the structure shown in Figures 1 to 3 and 5.
  • the end of the plug pin 311 is provided with a spherical portion, the diameter of the spherical portion is larger than the maximum diameter of the plug pin 311, and the end of the clamping groove 312 is also provided with a clamping protrusion, and the distance between the two clamping protrusions is smaller than the diameter of the spherical portion.
  • the plug pin 311 and the clamping groove 312 are both made of plastic, have a certain elasticity, can achieve a certain degree of elastic deformation, are easy to manufacture, and have low cost.
  • a piston cap which has a bearing cavity, and a reagent bottle is fixed in the bearing cavity.
  • the mouth of the reagent bottle is lower than the opening of the piston cap, and a sealing structure is provided to connect the detection box and the piston cap, thereby solving the problem of poor sealing of the contact part between the detection kit and the detection reagent bottle, avoiding the problem of gas escaping and drifting randomly and easy leakage of reagents, protecting the experimenters and avoiding environmental damage.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Dispersion Chemistry (AREA)
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Abstract

本发明提供了一种一体式取样密封试剂盒，包括检测盒、采样针、活塞帽以及试剂瓶。检测盒内部设置有检测试纸。采样针设置在试剂盒的第一端，包括主体部以及设置在主体部上的导流槽。活塞帽具有承载空腔，在承载空腔开口处设有密封结构，活塞帽通过密封结构与检测盒的第一端相互密封连接。试剂瓶位于承载空腔内，用于盛放检测试剂，在试剂瓶的瓶口处设有铝膜封闭，试剂瓶的瓶口低于活塞帽的开口。本发明提供的一体式取样密封试剂盒，将试剂瓶固定在承载空腔内，试剂瓶的瓶口低于所述活塞帽的开口，并且设置了密封结构，解决了检测试剂盒与检测试剂瓶接触部密封性不好的问题，避免了气体逸出和试剂容易泄露造成的环境破坏。

Description

一体式取样密封试剂盒 技术领域
本发明属于试剂检测技术领域，具体涉及一种一体式取样密封试剂盒。
 背景技术
试剂盒时用于盛放检测化学成分、药物残留、病毒种类等化学试剂的盒子。现有技术中，在试剂检测的过程中，在检测试剂盒上的采样针穿刺进入试剂盒时，会刺破缝在检测试剂瓶上的铝膜，但铝膜通常封在试剂瓶的瓶口上。在检测试剂盒与检测试剂瓶接触时铝膜夹在两者的接触面之间，会出现检测试剂盒与检测试剂瓶接触部密封性不好的问，会使逸出的气体随意飘散。并且在摇晃混合试剂瓶的过程中，导致试剂容易泄露，污染环境。
 技术问题
本发明实施例提供一种一体式取样密封试剂盒，旨在能够解决密封性不好，试剂容易泄露的问题。
 技术解决方案
本发明采用的技术方案是：提供一种一体式取样密封试剂盒，包括：检测盒，内部设置有检测试纸；采样针，设置在所述试剂盒的第一端，包括主体部以及设置在所述主体部上的导流槽，所述导流槽沿所述主体部的长度方向设置；活塞帽，具有承载空腔，在所述承载空腔开口处设有密封结构，所述活塞帽通过所述密封结构与所述检测盒的第一端相互密封连接；以及试剂瓶，位于所述承载空腔内，用于盛放检测试剂，在所述试剂瓶的瓶口处设有铝膜封闭，所述试剂瓶的瓶口低于所述活塞帽的开口。
在一种可能的实现方式中，所述承载空腔的内壁上设置有固定结构，所述试剂瓶通过固定结构卡装在活塞帽内部。
在一种可能的实现方式中，所述固定结构为多个设置在所述承载空腔内部上的凹槽，所述试剂瓶体外壁上均匀环形固设有固定块，所述试剂瓶安装后所述固定块抵靠在所述凹槽内部。
在一种可能的实现方式中，所述承载空腔的内部上还设置有多个辅助肋，所述辅助肋均沿所述活塞帽的深度方向设置，多个所述辅助肋环形设置在所述承载空腔的内壁上，且两相邻所述辅助肋之间间隔设置，所述凹槽与所述辅助肋一一对应且均位于所述辅助肋的侧面上。
在一种可能的实现方式中，所述辅助肋靠近所述活塞帽口部的一端均设置有导向斜面，所述辅助肋至少设有三条。
在一种可能的实现方式中，辅助肋的另一端还设置有定位凸块，所述定位凸块位于所述辅助肋的侧面且均向所述承载空腔的中心延伸，多个所述定位凸块用于定位所述试剂瓶的底部。
在一种可能的实现方式中，所述试剂瓶的底部还设置有与所述定位凸块配合的定位筒体。
在一种可能的实现方式中，所述密封结构包括设置在所述检测盒端面上的插接销、设置在所述活塞帽口部处的卡接槽、以及设置在所述检测盒与所述活塞帽之间的硅胶垫圈，所述插接销的端部卡接在所述卡接槽内，且所述插接销贯穿所述硅胶垫设置。
在一种可能的实现方式中，所述插接销的端部设置有球型部，所述球型部的直径大于所述插接销的最大直径，所述卡接槽的端部也设置有卡接凸起，两个所述卡接凸起之间的距离小于所述球型部的直径。
 有益效果
本实现方式中，本发明提供的一体式取样密封试剂盒的有益效果在于：与现有技术相比，设置了活塞帽，活塞帽具有承载空腔，将试剂瓶固定在承载空腔内，试剂瓶的瓶口低于所述活塞帽的开口，并且设置了密封结构，用于连接检测盒与活塞帽，解决了检测试剂盒与检测试剂瓶接触部密封性不好的问题，避免了气体逸出随意飘散和试剂容易泄露的问题，保护了实验人员，避免了环境破坏。
 附图说明
图1为本发明实施例提供的一体式取样密封试剂盒的结构构示意图；
图2为图1的A处局部放大结构示意图；
图3为本发明实施例提供的一体式取样密封试剂盒的活塞帽结构示意图；
图4为本发明实施例提供的一体式取样密封试剂盒的试剂瓶结构示意图；
图5为本发明实施例提供的一体式取样密封试剂盒的活塞帽与试剂瓶的安装结构示意图；
附图标记说明：
10、检测盒；20、采样针；21、主体部；22、导流槽；30、活塞帽；31、密封结构；311、插
接销；312、卡接槽；313、硅胶垫圈；32、固定结构；321、凹槽；322、辅助肋；33、定位凸块；40、
试剂瓶；41、固定块；42、定位筒体。
 本发明的最佳实施方式
为了使本发明所要解决的技术问题、技术方案及有益效果更加清楚明白，以下结合附图及实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
请一并参阅图1及图2，现对本发明提供的一体式取样密封试剂盒进行说明。一体式取样密封试剂盒，包括检测盒10、采样针20、活塞帽30以及试剂瓶40。检测盒10，内部设置有检测试纸。采样针20，设置在试剂盒的第一端，包括主体部21以及设置在主体部21上的导流槽22，导流槽22沿主体部21的长度方向设置。活塞帽30，具有承载空腔，在承载空腔开口处设有密封结构31，活塞帽30通过密封结构31与检测盒10的第一端相互密封连接。以及试剂瓶40，位于承载空腔内，用于盛放检测试剂，在试剂瓶40的瓶口处设有铝膜封闭，试剂瓶40的瓶口低于活塞帽30的开口。
本实施例提供的一体式取样密封试剂盒，与现有技术相比，设置了活塞帽30，活塞帽30具有承载空腔，将试剂瓶40固定在承载空腔内，试剂瓶40的瓶口低于活塞帽30的开口，并且设置了密封结构31，用于连接检测盒10与活塞帽30，解决了检测试剂盒与检测试剂瓶40接触部密封性不好的问题，避免了气体逸出随意飘散和试剂容易泄露的问题，保护了实验人员，避免了环境破坏。
在一些实施例中，上述活塞帽30可以采用如图3、图5所示结构。参见图3、图5，承载空腔的内壁上设置有固定结构32，试剂瓶40通过固定结构32卡装在活塞帽30内部。固定结构32在活塞帽30内部形成固定位，用于固定试剂瓶40在活塞帽30内的位置，将试剂瓶40固定在活塞帽30的中间位置，使采样针20准确进入试剂瓶40，加强配合关系，实用性好。
在一些实施例中，上述固定结构32可以采用如图3、图5所示结构。参见图3、图5，固定结构32为多个设置在承载空腔内部上的凹槽321，试剂瓶40体外壁上均匀环形固设有固定块41，试剂瓶40安装后固定块41抵靠在凹槽321内部。凹槽321还可以沿瓶体深度方向设置，与试剂瓶40体外壁上的固定块41一一对应，用于定位试剂瓶40在承载空腔内的位，结构简单，安装方便。
在一些实施例中，上述承载空腔可以采用如图3、图5所示结构。参见图3、图5，承载空腔的内部上还设置有多个辅助肋322，辅助肋322均沿活塞帽30的深度方向设置，多个辅助肋322环形设置在承载空腔的内壁上，且两相邻辅助肋322之间间隔设置，凹槽321与辅助肋322一一对应且均位于辅助肋322的侧面上。辅助肋322可以在完成定位的同时，减少活塞帽30的壁厚，降低成本，减轻一体式取样密封试剂盒的重量，实用性好。
在一些实施例中，上述辅助肋322可以采用如图3、图5所示结构。参见图3、图5，辅助肋322靠近活塞帽30口部的一端均设置有导向斜面，辅助肋322至少设有三条。导向斜面用于为试剂瓶40的安装提供导向，方便对齐安装，辅助肋322至少设有三条，为试剂瓶40的安装提供定位。
在一些实施例中，上述辅助肋322可以采用如图3、图5所示结构。参见图3、图5，辅助肋322的另一端还设置有定位凸块33，定位凸块33位于辅助肋322的侧面且均向承载空腔的中心延伸，多个定位凸块33用于定位试剂瓶40的底部。定位凸块33与辅助肋322数量相同，与辅助肋322一一对应，在活塞帽30底端相连，构成定位组，用于连接试剂瓶40，使试剂瓶40无法在活塞帽30内转动，结构简单，加工方便。
在一些实施例中，上述试剂瓶40可以采用如图4、图5所示结构。参见图4、图5，试剂瓶40的底部还设置有与定位凸块33配合的定位筒体42。定位筒体42为试剂瓶40的底部的限位口，用于插接在定位凸块33上，实现固定，装配方式简单，实用性高。
在一些实施例中，上述密封结构31可以采用如图1至图3、图5所示结构。参见图1至图3、图5，密封结构31包括设置在检测盒10端面上的插接销311、设置在活塞帽30口部处的卡接槽312、以及设置在检测盒10与活塞帽30之间的硅胶垫圈313，插接销311的端部卡接在卡接槽312内，且插接销311贯穿硅胶垫设置。插接销311环形均匀设置在检测盒10端面上，与环形均匀设置在活塞帽30口部处的卡接槽312一一对应，插接销311和卡接槽312可以设置多个，也可以为插接环和卡接槽312的，在插接环上套设有两个直径不同且平行的硅胶垫圈313，实现密封，结构简单，密封性好。
在一些实施例中，上述密封结构31可以采用如图1至图3、图5所示结构。参见图1至图3、图5，插接销311的端部设置有球型部，球型部的直径大于插接销311的最大直径，卡接槽312的端部也设置有卡接凸起，两个卡接凸起之间的距离小于球型部的直径。插接销311和卡接槽312均为塑料材质，具有一定弹性，可以实现一定程度的弹性形变，制作简便，成本低廉。
以上仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。
本发明的实施方式
为了使本发明所要解决的技术问题、技术方案及有益效果更加清楚明白，以下结合附图及实施例，对本发明进行进一步详细说明。应当理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限定本发明。
请一并参阅图1及图2，现对本发明提供的一体式取样密封试剂盒进行说明。一体式取样密封试剂盒，包括检测盒10、采样针20、活塞帽30以及试剂瓶40。检测盒10，内部设置有检测试纸。采样针20，设置在试剂盒的第一端，包括主体部21以及设置在主体部21上的导流槽22，导流槽22沿主体部21的长度方向设置。活塞帽30，具有承载空腔，在承载空腔开口处设有密封结构31，活塞帽30通过密封结构31与检测盒10的第一端相互密封连接。以及试剂瓶40，位于承载空腔内，用于盛放检测试剂，在试剂瓶40的瓶口处设有铝膜封闭，试剂瓶40的瓶口低于活塞帽30的开口。
本实施例提供的一体式取样密封试剂盒，与现有技术相比，设置了活塞帽30，活塞帽30具有承载空腔，将试剂瓶40固定在承载空腔内，试剂瓶40的瓶口低于活塞帽30的开口，并且设置了密封结构31，用于连接检测盒10与活塞帽30，解决了检测试剂盒与检测试剂瓶40接触部密封性不好的问题，避免了气体逸出随意飘散和试剂容易泄露的问题，保护了实验人员，避免了环境破坏。
在一些实施例中，上述活塞帽30可以采用如图3、图5所示结构。参见图3、图5，承载空腔的内壁上设置有固定结构32，试剂瓶40通过固定结构32卡装在活塞帽30内部。固定结构32在活塞帽30内部形成固定位，用于固定试剂瓶40在活塞帽30内的位置，将试剂瓶40固定在活塞帽30的中间位置，使采样针20准确进入试剂瓶40，加强配合关系，实用性好。
在一些实施例中，上述固定结构32可以采用如图3、图5所示结构。参见图3、图5，固定结构32为多个设置在承载空腔内部上的凹槽321，试剂瓶40体外壁上均匀环形固设有固定块41，试剂瓶40安装后固定块41抵靠在凹槽321内部。凹槽321还可以沿瓶体深度方向设置，与试剂瓶40体外壁上的固定块41一一对应，用于定位试剂瓶40在承载空腔内的位，结构简单，安装方便。
在一些实施例中，上述承载空腔可以采用如图3、图5所示结构。参见图3、图5，承载空腔的内部上还设置有多个辅助肋322，辅助肋322均沿活塞帽30的深度方向设置，多个辅助肋322环形设置在承载空腔的内壁上，且两相邻辅助肋322之间间隔设置，凹槽321与辅助肋322一一对应且均位于辅助肋322的侧面上。辅助肋322可以在完成定位的同时，减少活塞帽30的壁厚，降低成本，减轻一体式取样密封试剂盒的重量，实用性好。
在一些实施例中，上述辅助肋322可以采用如图3、图5所示结构。参见图3、图5，辅助肋322靠近活塞帽30口部的一端均设置有导向斜面，辅助肋322至少设有三条。导向斜面用于为试剂瓶40的安装提供导向，方便对齐安装，辅助肋322至少设有三条，为试剂瓶40的安装提供定位。
在一些实施例中，上述辅助肋322可以采用如图3、图5所示结构。参见图3、图5，辅助肋322的另一端还设置有定位凸块33，定位凸块33位于辅助肋322的侧面且均向承载空腔的中心延伸，多个定位凸块33用于定位试剂瓶40的底部。定位凸块33与辅助肋322数量相同，与辅助肋322一一对应，在活塞帽30底端相连，构成定位组，用于连接试剂瓶40，使试剂瓶40无法在活塞帽30内转动，结构简单，加工方便。
在一些实施例中，上述试剂瓶40可以采用如图4、图5所示结构。参见图4、图5，试剂瓶40的底部还设置有与定位凸块33配合的定位筒体42。定位筒体42为试剂瓶40的底部的限位口，用于插接在定位凸块33上，实现固定，装配方式简单，实用性高。
在一些实施例中，上述密封结构31可以采用如图1至图3、图5所示结构。参见图1至图3、图5，密封结构31包括设置在检测盒10端面上的插接销311、设置在活塞帽30口部处的卡接槽312、以及设置在检测盒10与活塞帽30之间的硅胶垫圈313，插接销311的端部卡接在卡接槽312内，且插接销311贯穿硅胶垫设置。插接销311环形均匀设置在检测盒10端面上，与环形均匀设置在活塞帽30口部处的卡接槽312一一对应，插接销311和卡接槽312可以设置多个，也可以为插接环和卡接槽312的，在插接环上套设有两个直径不同且平行的硅胶垫圈313，实现密封，结构简单，密封性好。
在一些实施例中，上述密封结构31可以采用如图1至图3、图5所示结构。参见图1至图3、图5，插接销311的端部设置有球型部，球型部的直径大于插接销311的最大直径，卡接槽312的端部也设置有卡接凸起，两个卡接凸起之间的距离小于球型部的直径。插接销311和卡接槽312均为塑料材质，具有一定弹性，可以实现一定程度的弹性形变，制作简便，成本低廉。
以上仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内所作的任何修改、等同替换和改进等，均应包含在本发明的保护范围之内。
 工业实用性
与现有技术相比，设置了活塞帽，活塞帽具有承载空腔，将试剂瓶固定在承载空腔内，试剂瓶的瓶口低于所述活塞帽的开口，并且设置了密封结构，用于连接检测盒与活塞帽，解决了检测试剂盒与检测试剂瓶接触部密封性不好的问题，避免了气体逸出随意飘散和试剂容易泄露的问题，保护了实验人员，避免了环境破坏。

Claims (9)

  1. .一体式取样密封试剂盒，其特征在于，包括：检测盒，内部设置有检测试纸；采样针，设置在所述试剂盒的第一端，包括主体部以及设置在所述主体部上的导流槽，所述导流槽沿所述主体部的长度方向设置；活塞帽，具有承载空腔，在所述承载空腔开口处设有密封结构，所述活塞帽通过所述密封结构与所述检测盒的第一端相互密封连接；以及试剂瓶，位于所述承载空腔内，用于盛放检测试剂，在所述试剂瓶的瓶口处设有铝膜封闭，所述试剂瓶的瓶口低于所述活塞帽的开口。
  2. .如权利要求1所述的一体式取样密封试剂盒，其特征在于，所述承载空腔的内壁上设置有固定结构，所述试剂瓶通过固定结构卡装在活塞帽内部。
  3. .如权利要求2所述的一体式取样密封试剂盒，其特征在于，所述固定结构为多个设置在所述承载空腔内部上的凹槽，所述试剂瓶体外壁上均匀环形固设有固定块，所述试剂瓶安装后所述固定块抵靠在所述凹槽内部。
  4. .如权利要求3所述的一体式取样密封试剂盒，其特征在于，所述承载空腔的内部上还设置有多个辅助肋，所述辅助肋均沿所述活塞帽的深度方向设置，多个所述辅助肋环形设置在所述承载空腔的内壁上，且两相邻所述辅助肋之间间隔设置，所述凹槽与所述辅助肋一一对应且均位于所述辅助肋的侧面上。
  5. .如权利要求4所述的一体式取样密封试剂盒，其特征在于，所述辅助肋靠近所述活塞帽口部的一端均设置有导向斜面，所述辅助肋至少设有三条。
  6. .如权利要求5所述的一体式取样密封试剂盒，其特征在于，所述辅助肋的另一端还设置有定位凸块，所述定位凸块位于所述辅助肋的侧面且均向所述承载空腔的中心延伸，多个所述定位凸块用于定位所述试剂瓶的底部。
  7. .如权利要求6所述的一体式取样密封试剂盒，其特征在于，所述试剂瓶的底部还设置有与所述定位凸块配合的定位筒体。
  8. .如权利要求1所述的一体式取样密封试剂盒，其特征在于，所述密封结构包括设置在所述检测盒端面上的插接销、设置在所述活塞帽口部处的卡接槽、以及设置在所述检测盒与所述活塞帽之间的硅胶垫圈，所述插接销的端部卡接在所述卡接槽内，且所述插接销贯穿所述硅胶垫设置。
  9. .如权利要求8所述的一体式取样密封试剂盒，其特征在于，所述插接销的端部设置有球型部，所述球型部的直径大于所述插接销的最大直径，所述卡接槽的端部也设置有卡接凸起，两个所述卡接凸起之间的距离小于所述球型部的直径。
PCT/CN2023/115411 2022-10-26 2023-08-29 一体式取样密封试剂盒 WO2024087868A1 (zh)

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