WO2024075482A1 - Composition de résine pour simulateur médical et produit moulé associé - Google Patents

Composition de résine pour simulateur médical et produit moulé associé Download PDF

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Publication number
WO2024075482A1
WO2024075482A1 PCT/JP2023/033313 JP2023033313W WO2024075482A1 WO 2024075482 A1 WO2024075482 A1 WO 2024075482A1 JP 2023033313 W JP2023033313 W JP 2023033313W WO 2024075482 A1 WO2024075482 A1 WO 2024075482A1
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resin composition
resin
polyol
composition according
mass
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PCT/JP2023/033313
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English (en)
Japanese (ja)
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英利香 金子
悠太 萩原
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デンカ株式会社
学校法人 聖マリアンナ医科大学
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Publication of WO2024075482A1 publication Critical patent/WO2024075482A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
    • G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B9/00—Simulators for teaching or training purposes

Definitions

  • the present invention relates to a resin composition for medical simulators and molded articles made from the composition.
  • Diagnosis using ultrasound equipment can be performed simply by placing an ultrasound probe outside the body, so it is unlikely to cause damage to tissues or organs and has a wide range of applications, making it an important method of medical diagnosis today.
  • Patent Documents 1 and 2 As a result, there is an increasing demand for technical training models compatible with ultrasound diagnostic equipment, and ultrasound diagnostic phantoms have been proposed to improve skills and the quality of medical procedures (Patent Documents 1 and 2).
  • the objective of the present invention is to provide a resin composition and a molded article thereof that improves the visibility of tissues and blood vessels during ultrasound diagnostic training.
  • the present invention comprises the following: [1] A resin composition for a medical simulator, comprising a curable resin and organic fibers. [2] The resin composition according to [1], wherein the resin composition has a maximum tan ⁇ of 0.4 or less at 25° C. in a viscoelastic measurement at a frequency of 0.01 to 100 Hz, and a maximum storage modulus of 10 6 Pa or less at 25° C. in a frequency of 0.01 to 10,000 Hz. [3] The resin composition according to [1] or [2], wherein the resin composition has an Asker E hardness of 10 or less.
  • the present invention provides a resin composition and a molded article thereof that improves the visibility of tissues and blood vessels during ultrasound diagnostic training.
  • 1 is a diagram showing an ultrasound image of the human neck.
  • 1 is a diagram showing an echo image of a neck ultrasound diagnostic phantom having a simulated blood vessel therein, which was produced using a resin composition according to one embodiment of the present invention.
  • 1 is a diagram showing an echo image of a neck ultrasound diagnostic phantom having a simulated blood vessel therein, which was produced using a resin composition according to a comparative example.
  • the resin composition for a medical simulator of the present invention contains a curable resin and organic fibers.
  • the curable resin is not particularly limited as long as it can obtain the effects of the present invention, and may include one or more selected from polyurethane resins, silicone resins, phenol resins, epoxy resins, melamine resins, urea resins, unsaturated polyester resins, alkyd resins, and thermosetting polyimide resins.
  • a curable resin selected from polyurethane resins or silicone resins may be preferably used.
  • the content of the curable resin is preferably 30 to 75 mass%, more preferably 33 to 75 mass%, and even more preferably 35 to 75 mass%, relative to the total mass of the resin composition.
  • the curable resin may be a polyurethane resin made from a polyol and a polyisocyanate compound.
  • the number average molecular weight of the polyurethane resin is preferably 10 4 to 10 10 , and more preferably 10 4 to 10 9 .
  • the number average molecular weight can be determined based on gel permeation chromatography (GPC) under the following conditions.
  • crosslink density of polyurethane resins can also affect acoustic attenuation.
  • This crosslink density is determined primarily by the molecular weight of the polyol, and as the molecular weight increases, the density of crosslinking points formed by reaction with isocyanate decreases. As a result, the molecules become more mobile, energy loss during ultrasonic propagation is reduced, and the acoustic attenuation coefficient tends to become smaller.
  • the structure of the polyol in the polyurethane resin, its molecular weight, and the amount of isocyanate compound added are important in controlling acoustic attenuation.
  • the crosslinking index (CI) is an index that represents the amount of polyol components that contribute to crosslinking and the amount of polyol components that have only reacted insufficiently in a polyurethane resin.
  • the crosslinking index which indicates the crosslinking density of a polyurethane resin, is defined by the following formula. ...Equation (1)
  • WU Total weight of polyurethane resin [g]
  • W0 Weight [g] of the isocyanate compound contained in WU [g] of the polyurethane resin
  • WOH Weight [g] of polyol contained in WU [g] of polyurethane resin
  • MOH Number average molecular weight of polyol [g/mol]
  • EqOH active hydroxyl group equivalent of polyol [g/eq]
  • Eq0 active isocyanate equivalent of the isocyanate compound [g/eq]
  • COH Total number of moles of polyols [mol] contained in WU [g] of polyurethane resin [OH]: Number of moles [mol] of active hydroxyl groups contained in WU [g] of polyurethane resin [NCO]: number of moles [mol] of active isocyanate groups contained in WU [g] of
  • the crosslinking index of the polyurethane resin is designed to be greater than 5000.
  • Polyol Representative examples of the polyol include polyether polyol, polyester polyol, and polycarbonate polyol.
  • the hardness of the urethane resin tends to vary depending on the number average molecular weight of the polyol; when the number average molecular weight is large, the hardness tends to be low, and when the number average molecular weight is small, the hardness tends to be high.
  • the number average molecular weight of the polyol is preferably 1,000 to 8,000 in terms of ease of availability, and more preferably 4,000 to 7,000 in order to produce a solid that is easy to handle.
  • the number average molecular weight can be measured using gel permeation chromatography (GPC).
  • the hydroxyl value of the polyol is preferably 20-160, more preferably 20-80, and even more preferably 25-60.
  • the hydroxyl value of the polyol can be determined by titration in accordance with JIS K 1557-1, where the unit of the hydroxyl value is mgKOH/g.
  • the active hydroxyl group equivalent of the polyol is preferably 350 to 2805 equivalents/kg, more preferably 701 to 2805 equivalents/kg, and even more preferably 935 to 2244 equivalents/kg.
  • the active hydroxyl group equivalent of a polyol can be determined by measuring the amount of hydroxyl groups by a known method. An example of a method for determining the active hydroxyl group equivalent from the hydroxyl value will be described below.
  • the polyol is dissolved in a pyridine solution containing acetic anhydride, and the hydroxyl groups are acetylated. The excess acetylation reagent is then hydrolyzed with water, and the resulting acetic acid is titrated with potassium hydroxide.
  • the end point is the inflection point on the titration curve, and the hydroxyl value of the polyol can be calculated from the amount of potassium hydroxide solution titrated up to the end point.
  • the active hydroxyl equivalent can be calculated from this hydroxyl value.
  • the polyetherol is not particularly limited as long as it has two or more functional groups in the molecule, and any appropriate polyether polyol can be used. These can be used alone or in combination of two or more. Polyether polyols are described below.
  • the polyether polyol components include (oxypropylene) glycol, oxyethylene glycol, oxytetramethylene glycol, ethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,4-butanediol, neopentyl glycol, pentanediol, 1,6-hexanediol, 1,8-octanediol, 1,10-decanediol, 1-methyl-1,3-butylene glycol, 2-methyl-1,3-butylene glycol, 1-methyl-1,4-pentylene glycol, 2-methyl-1,4-pentylene glycol, 1,2-dimethyl-neopentyl glycol, 2,3-dimethyl-neopentyl glycol, and the like.
  • polyether polyols examples include glycol, 1-methyl-1,5-pentylene glycol, 2-methyl-1,5-pentylene glycol, 3-methyl-1,5-pentylene glycol, 1,2-dimethylbutylene glycol, 1,3-dimethylbutylene glycol, 2,3-dimethylbutylene glycol, 1,4-dimethylbutylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, 1,4-cyclohexanedimethanol, 1,4-cyclohexanediol, bisphenol A, bisphenol F, hydrogenated bisphenol A, hydrogenated bisphenol F, and polyoxyethylene polyoxypropylene glycol. These can be polymerized alone or in combination by a known method to obtain a polyether polyol.
  • the isocyanate compound is not particularly limited as long as it is an isocyanate compound having two or more isocyanate groups, and any appropriate one can be adopted. These can be used alone or in combination of two or more.
  • the isocyanate compound will be described below, but is not limited thereto.
  • the isocyanate compounds include, for example, aliphatic diisocyanates such as tetramethylene diisocyanate, dodecamethylene diisocyanate, 1,4-butane diisocyanate, hexamethylene diisocyanate, 2,2,4-trimethylhexamethylene diisocyanate, 2,4,4-trimethylhexamethylene diisocyanate, lysine diisocyanate, 2-methylpentane-1,5-diisocyanate, and 3-methylpentane-1,5-diisocyanate; isophorone diisocyanate, hydrogenated xylylene diisocyanate, 4,4'-cyclohexylmethane diisocyanate, 1,4-cyclohexane diisocyanate, methylcyclohexylene diisocyanate, and 1,3-bis(isocyanate methyl ) cyclohexane and other alicyclic diisocyanates; aromatic diisocyanates
  • the isocyanate compound can also be prepared as a modified product within the scope of the present invention, so long as the effects of the present invention are not impaired.
  • modified polyisocyanates include, but are not limited to, polymers (dimers (e.g., uretdione modified products), trimers (e.g., isocyanurate modified products, iminooxadiazinedione modified products), biuret modified products (e.g., biuret modified products produced by reaction with water), allophanate modified products (e.g., allophanate modified products produced by reaction with monool or low molecular weight polyol), polyol modified products (e.g., polyol modified products produced by reaction with low molecular weight polyol or high molecular weight polyol), oxadiazinetrione modified products (e.g., oxadiazinetrione produced by reaction with carbon dioxide), and carbodiimide modified products (carbodiimide modified products produced by decarboxylation condensation reaction
  • the active isocyanate equivalent of the isocyanate compound is preferably 160-420, and more preferably 160-280.
  • the active isocyanate equivalent of an isocyanate compound can be determined by measuring the amount of hydroxyl groups by a known method. An example of a method for measuring the isocyanate equivalent will be described below.
  • the isocyanate equivalent can be calculated from the titration amount up to the end point.
  • a suitable amount of catalyst that promotes the reaction between the hydroxyl group of the polyol and the isocyanate group of the isocyanate compound may be added to the polyol or polyisocyanate.
  • a known urethane catalyst can be used as the catalyst, and specific examples of the catalyst include organic metal compounds such as dibutyltin dilaurate, dibutyltin diacetate, and dioctyltin dilaurate, and organic amines such as triethylenediamine and triethylamine, and salts thereof. These catalysts can be used alone or in combination of two or more.
  • the content of the urethanization catalyst is preferably 0.01 to 0.05 mass %, and more preferably 0.02 to 0.04 mass %, relative to the total mass of the resin composition.
  • a silicone-based resin can be used as the curable resin.
  • silicone-based resins include those that are cured by addition reaction or radical crosslinking reaction.
  • the addition reaction curable resin include those that contain a diorganosiloxane having an alkenyl group, an MQ resin having R 3 SiO 0.5 and SiO 2 units, an organohydrogenpolysiloxane having a plurality of SiH groups, a platinum catalyst, an addition reaction inhibitor, and an organic solvent, as described in JP 2015-193803 A.
  • radical crosslinking reaction curable resin examples include those that contain a diorganopolysiloxane that may or may not have an alkenyl group, an MQ resin having R 3 SiO 0.5 and SiO 2 units, an organic peroxide, and an organic solvent, as described in JP 2015-193803 A.
  • R is a substituted or unsubstituted monovalent hydrocarbon group having 1 to 10 carbon atoms.
  • MQ resin contains a lot of silanols, so adding this improves adhesive strength, but since it is not crosslinkable, it is not molecularly bonded to the polysiloxane.
  • Modified siloxanes having a group selected from amino groups, oxirane groups, oxetane groups, polyether groups, hydroxyl groups, carboxyl groups, mercapto groups, methacryl groups, acrylic groups, phenol groups, silanol groups, carboxylic anhydride groups, aryl groups, aralkyl groups, amide groups, ester groups, and lactone rings can also be added to the silicone resin.
  • the modified siloxanes may be modified at one end, both ends, or the side chains.
  • the organic fiber is used as an adjustment material for the acoustic performance of the composition.
  • the organic fiber include aramid fiber, cellulose fiber, nylon fiber, vinylon fiber, polyester fiber, acrylic fiber, polyolefin fiber, rayon fiber, polyvinyl chloride fiber, polyvinylidene chloride fiber, polyurethane fiber, polylactic acid fiber, plant fiber such as cotton or hemp, and animal fiber such as wool or silk. These may be used alone or in combination of two or more.
  • Examples of the cross-sectional shape of the organic fibers include a circle, an ellipse, and a polygon.
  • the ratio L/D of the average length L to the average fiber diameter D of the organic fibers is, for example, more than 10, preferably 50 or more, and more preferably 100 or more.
  • the upper limit of L/D is not particularly specified, but is, for example, 10,000.
  • the average fiber diameter D of the organic fibers is, for example, 10 to 80 ⁇ m, preferably 15 to 70 ⁇ m, and more preferably 20 to 60 ⁇ m.
  • the average length L of the organic fibers is, for example, 0.05 to 10 mm, preferably 0.1 to 8 mm, and more preferably 0.2 to 5 mm.
  • the organic fiber content is preferably 0.5 to 3.0% by mass, and more preferably 1.0 to 3.0% by mass, relative to the total mass of the resin composition.
  • ultrasound inserted into the composition is scattered, and when it is used as a diagnostic phantom, muscle tissue, etc., which appears white in an echo image, can be suitably reproduced.
  • the echo image can be made closer to that of the human body.
  • the echo image can be displayed more clearly, both overall and in fine detail.
  • the resin composition may contain additives such as a plasticizer, a colorant, a flame retardant, a stabilizer, and a release agent.
  • the resin composition contains a plasticizer as necessary.
  • the plasticizer is not particularly limited, but may be, for example, a phthalate ester, a trimellitate ester, a pyromellitate ester, an aliphatic monobasic acid ester, an aliphatic dibasic acid ester, a phosphoric acid ester, or an ester of a polyhydric alcohol. These may be used alone or in combination of two or more kinds.
  • the above phthalate esters include dimethyl phthalate, diethyl phthalate, dipropyl phthalate, diisopropyl phthalate, dibutyl phthalate, diisobutyl phthalate, diamyl phthalate, di-n-hexyl phthalate, dicyclohexyl phthalate, diheptyl phthalate, di-n-octyl phthalate, dinonyl phthalate, diisononyl phthalate, diisodecyl phthalate, diundecyl phthalate, ditridecyl phthalate, diphenyl phthalate, di(2-ethylhexyl) phthalate, di(2-butoxyethyl) phthalate, benzyl 2-ethylhexyl phthalate, benzyl n-butyl phthalate, benzyl isononyl phthalate, and dimethyl isophthalate.
  • trimellitic acid esters examples include tributyl trimellitate, trihexyl trimellitate, tri-n-octyl trimellitate, tri-2-ethylhexyl trimellitate, triisodecyl trimellitate, etc.
  • Examples of the pyromellitic acid ester include tetrabutyl pyromellitic acid, tetrahexyl pyromellitic acid, tetra-n-octyl pyromellitic acid, tetra-2-ethylhexyl pyromellitic acid, and tetradecyl pyromellitic acid.
  • Examples of the aliphatic monobasic acid ester include butyl oleate, methyl oleate, methyl octanoate, butyl octanoate, methyl dodecanoate, butyl dodecanoate, methyl palmitate, butyl palmitate, methyl stearate, butyl stearate, methyl linoleate, butyl linoleate, methyl isostearate, butyl isostearate, methyl acetyl ricinoleate, and butyl acetyl ricinoleate.
  • the above aliphatic dibasic acid esters include dimethyl adipate, diethyl adipate, di-n-propyl adipate, diisopropyl adipate, diisobutyl adipate, di-n-octyl adipate, di(2-ethylhexyl) adipate (bis(2-ethylhexyl) adipate), diisononyl adipate, diisodecyl adipate, di(2-butoxyethyl) adipate, di(butyldiglycol) adipate, and heptyl nonyl adipate.
  • the above phosphate esters include trimethyl phosphate, triethyl phosphate, tributyl phosphate, tri-n-amyl phosphate, triphenyl phosphate, tri-o-cresyl phosphate, trixylenyl phosphate, diphenyl 2-ethylhexyl phosphate, diphenylcresyl phosphate, tris(2-butoxyethyl) phosphate, tris(2-ethylhexyl) phosphate, etc.
  • Esters of the above polyhydric alcohols include diethylene glycol diacetylate, diethylene glycol dibenzoate, glycerol monooleate, glycerol tributyrate, glycerol triacetate, glyceryl tri(acetyl ricinoleate), triethylene glycol diacetate, etc.
  • the content of the plasticizer is preferably 20 to 80 mass %, more preferably 25 to 75 mass %, and even more preferably 30 to 70 mass %, relative to the total mass of the resin composition.
  • Examples of the colorant include master batches, colored pellets, dry colors, paste colors, liquid colors, and inks. The colorant may be kneaded with a resin in an extruder and colored, and a method of kneading a master batch with a resin in an extruder and coloring the resin is preferred.
  • Examples of the colorant used in the colorant include carbon black, inorganic pigments, organic pigments, basic dyes, and acid dyes.
  • the amount of the colorant added is preferably 0.01% by mass to 5% by mass, more preferably 0.02% by mass to 3% by mass, and even more preferably 0.05% by mass to 2% by mass, based on the total mass of the resin composition, as the final colorant content.
  • flame retardants examples include bromine-based flame retardants, phosphorus-based flame retardants, nitrogen-based flame retardants, hydrated metal compounds, etc.
  • the content of the flame retardant is preferably 0.01 to 1.0 mass%, more preferably 0.01 to 0.5 mass%, and even more preferably 0.01 to 0.3 mass%, relative to the total mass of the resin composition.
  • phenol-based antioxidants such as 2,6-di-t-butyl-4-methylphenol, 2-t-butyl-6-(3-t-butyl-2-hydroxy-5-methylbenzyl)-4-methylphenyl acrylate, 2-[1-(2-hydroxy-3,5-di-t-pentylphenyl)-ethyl]-4,6-di-pentylphenyl acrylate, n-octadecyl-3-(4'-hydroxy-3',5'-di-t-butylphenyl)propionate, phosphorus-based antioxidants such as 2,2-methylenebyl(4,6-di-t-butylphenyl)octylphosphite, trisnonylphenylphosphite, etc.
  • the content of the stabilizer is preferably 0.1 to 3.0% by mass, more preferably 0.1 to 2.5% by mass, and even more preferably 0.1 to 2.0% by mass, based on the total mass of the resin composition.
  • release agent natural wax such as carnauba wax, synthetic wax, higher fatty acid such as zinc stearate and its metal salt, and paraffin can be used.
  • the content of the release agent is preferably 0.1 to 2.0 mass%, more preferably 0.1 to 1.5 mass%, and further preferably 0.1 to 1.0 mass%, based on the total mass of the resin composition.
  • the resin composition contains a curable resin and organic fibers, and is suitable for producing a medical simulator, in particular, an ultrasound diagnostic phantom.
  • the maximum value of tan ⁇ at 25°C at frequencies of 0.01 to 100 Hz is preferably 0.4 or less, more preferably 0.01 to 0.35, and even more preferably 0.01 to 0.3.
  • the ultrasonic attenuation effect of the resin composition becomes appropriate, and ultrasonic echo visibility close to that of the human body and the inside can be clearly observed.
  • the maximum storage modulus of the resin composition at 25° C. in a frequency range of 0.01 to 10,000 Hz is preferably 10 6 Pa or less, more preferably 10 3 to 10 6 Pa, and even more preferably 10 4 to 10 6 Pa.
  • the maximum storage modulus is 10 6 Pa or less, the shape retention of the resin composition is good, and the resin composition can be easily handled as a simulator model.
  • More detailed conditions for measuring the viscoelasticity of the resin composition are as follows.
  • the resin composition is punched out to produce a molded product having a thickness of 5 mm and a diameter of 20 mm.
  • the samples are stored in a room at 23° C. and 50% RH for 24 hours for aging treatment.
  • RSA-III dynamic viscoelasticity measuring device
  • E' storage modulus
  • E loss modulus
  • the Asker E hardness of the resin composition is preferably 10 or less, more preferably 0 to 8, and even more preferably 0 to 4. Having an Asker E hardness of 10 or less gives the resin composition a feel similar to that of the human body, and the feel of pressing an ultrasonic probe against the resin composition during ultrasonic diagnosis also feels similar to that of the human body, which is expected to improve medical techniques in ultrasonic diagnosis. Furthermore, having an Asker E hardness of 10 or less makes it easier for the ultrasonic probe to follow the area to be diagnosed, improving the visibility of ultrasonic echo images.
  • the Asker E hardness can be measured in accordance with JIS K 6253-3:2012.
  • the resin composition has an acoustic attenuation rate of preferably 0.3 to 1.5 dB/cm/MHz, more preferably 0.3 to 1.2 dB/cm/MHz, and even more preferably 0.3 to 1.0 dB/cm/MHz.
  • the acoustic attenuation rate of the resin composition can be measured, for example, by the method described in the Examples below.
  • the sound velocity in the resin composition is preferably 1200 to 1700 m/s, and more preferably 1200 to 1600 m/s. This range is equivalent to that of fatty tissue in a living body.
  • the sound speed of the resin composition can be measured using the same measuring instrument as for the acoustic attenuation rate by calculating the difference in the arrival time of the received wave when a test piece is placed on the measuring instrument and when it is not placed on the measuring instrument, and taking the tolerance function of the waveform obtained with an oscilloscope. The difference in the arrival time of the received wave can then be calculated using the following formula (2).
  • C1 The speed of sound in water at the water temperature at the time of measurement (m/s).
  • C2 Sound velocity of the test piece (m/s).
  • t thickness of test piece (m).
  • ⁇ delay time ⁇ (s) of the arrival of the received wave when the test piece is installed.
  • the density of the resin composition is preferably 900 to 1300 kg/m 3 , and more preferably 950 to 1200 kg/m 3.
  • the sound speed and density are correlated with acoustic impedance, and by adjusting the density and sound speed within a specified range, visibility in ultrasonic echoes becomes close to that of the human body and is good.
  • the density of the resin composition can be measured using an electronic specific gravity meter based on JIS K7112:1999.
  • the molded article of the present invention is produced by molding the resin composition of the present invention.
  • the molded article can be used as a medical simulator, for example, for the head, neck, chest, abdomen, pelvis, upper limbs, and lower limbs.
  • additives such as colorants such as pigments and dyes, fragrances, antioxidants, antibacterial agents, etc. may be used within the scope that does not impede the purpose.
  • colorants such as pigments and dyes, fragrances, antioxidants, antibacterial agents, etc.
  • the molded product can be molded by known molding methods.
  • the curable composition is injected into a mold of your choice, heated, cooled, and solidified.
  • multiple parts can be molded separately using injection molding or other methods, and then bonded together to complete the medical simulator.
  • the molded product can be used as an ultrasound diagnostic phantom.
  • the molded product can be used as an ultrasound diagnostic phantom having simulated blood vessels made of resin such as epoxy resin inside.
  • the molded product can be used as an ultrasound diagnostic phantom of the neck including the carotid artery where ultrasound diagnosis is actually performed.
  • the methods for evaluating various properties of the resin compositions prepared in the examples and comparative examples are as follows.
  • Two Shodex KD-806M columns (manufactured by Showa Denko K.K.) and one Shodex KD-802 column (manufactured by Showa Denko K.K.) were arranged in series in a gel permeation chromatography (GPC) apparatus (manufactured by WATERS Corporation), and the measurement was performed with an RI (Refractive Index) detector at 40° C. using N,N′-dimethylformamide as a developing solvent.
  • the number average molecular weight obtained is a polyethylene glycol equivalent value.
  • the density of the resin composition was measured using an electronic specific gravity meter (MD-300S, manufactured by Alpha Mirage Co., Ltd.) based on the method for measuring density and specific gravity of plastics - non-foamed plastics (JIS K7112:1999).
  • the probe used for measuring the acoustic attenuation coefficient was an ultrasonic transducer (transmitter) (V303 (center frequency 1 MHz) manufactured by Olympus NDT Inc.) and a hydrophone (receiver) (needle-type hydrophone manufactured by Toray Engineering Co., Ltd.).
  • the transducer and hydrophone were fixed in the tank using a jig so that the centers of the sound axes were aligned.
  • the distance between the transducer and hydrophone was 40 mm.
  • the cured resin composition was poured into a mold measuring 50 mm x 50 mm and 50 mm thick, and the resin was cured by heating at 90°C for 2 hours. The mold was then demolded to obtain a plate-shaped test specimen measuring 50 mm x 50 mm and 20 mm thick. The test specimen was fixed using a jig between the transducer and hydrophone of the above experimental system so that the incident angle of the ultrasonic signal to the plate-shaped test specimen was 0°.
  • an 8-cycle sine wave (transmitting voltage 100V) was transmitted from the transducer using a function generator (NF Circuit Design Co., Ltd., WF1946).
  • the maximum amplitude of the received voltage of the hydrophone when each test piece was installed and when no test piece was installed was then determined using an oscilloscope (LeCroy Japan Co., Ltd., WaveRunner 64Xi).
  • the acoustic attenuation rate was calculated using the following formula (3) from the maximum amplitude of the voltage when the test piece was installed and when it was not installed in the measurement system.
  • ⁇ attenuation coefficient (dB/cm/MHz)
  • t thickness of the test piece (cm).
  • A' maximum amplitude value (mV) of the received voltage when the test piece is installed.
  • A0 Maximum amplitude value (mV) of the received voltage when no test piece is installed.
  • Z 1 Acoustic impedance of water (MRayls).
  • Z2 Acoustic impedance of the test specimen (MRayls).
  • the acoustic impedance used in the above formula (3) is calculated as the product of density and sound speed.
  • the sound speed and density required for the calculation were calculated by actual measurement.
  • the sound speed was calculated by taking the cross-correlation of the waveforms obtained with an oscilloscope to find the difference in the arrival time of the received wave when a test piece was installed and when it was not installed in the measurement system, using a similar measurement system for the acoustic attenuation rate, and the sound speed was calculated from this difference in the arrival time of the received wave using the following formula (2).
  • C 1 The speed of sound in water (m/s) at the water temperature at the time of measurement.
  • C2 Sound velocity of the test piece (m/s).
  • t thickness of test piece (m).
  • ⁇ delay time ⁇ (s) of the arrival of the received wave when the test piece is installed.
  • Examples 2 to 9 and Comparative Example 2 Except for the raw materials and compositions of the resin compositions shown in Tables 1 and 2, resin compositions were prepared in the same manner as in Example 1, and physical properties were measured in the same manner as in Example 1. The results are shown in Tables 1 and 2. The crosslinking index of the resin compositions in the above examples was all over 5,000.
  • a neck ultrasound diagnostic phantom was produced using the resin compositions of the above examples and comparative examples as the outer shell and having a simulated blood vessel made of an epoxy resin inside, and an echo image was taken.
  • Fig. 1 shows an actual echo image of the neck of a human body.
  • FIG. 2 is an echo image taken of a neck ultrasound diagnostic phantom prepared using the resin composition of Example 1, in which, similar to FIG. 1, the blood vessels appear black and the outer periphery appears white.
  • FIG. 3 is an echo image taken of a neck ultrasound diagnostic phantom made using the resin composition of Comparative Example 1. There is little difference in brightness between the blood vessels and the outer shell, and both appear black, indicating that the visibility of the blood vessels was not adequately reproduced.
  • the resin composition for medical simulators of the present invention can be used to manufacture medical simulators.

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Abstract

L'invention concerne une composition de résine pour simulateur médical ainsi qu'un produit moulé associé offrant une visibilité améliorée d'un vaisseau sanguin lors de la formation au diagnostic par ultrasons.　Cette composition de résine pour simulateur médical comprend une résine durcissable et une fibre organique.
PCT/JP2023/033313 2022-10-07 2023-09-13 Composition de résine pour simulateur médical et produit moulé associé WO2024075482A1 (fr)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011209691A (ja) * 2010-03-09 2011-10-20 Canon Inc 光音響整合材及び人体組織模擬材料
JP2018011772A (ja) * 2016-07-21 2018-01-25 キヤノン株式会社 ファントムおよび評価方法
JP2020166187A (ja) * 2019-03-29 2020-10-08 国立大学法人東北大学 医療処置の訓練用皮膚モデル、医療処置の訓練用皮膚モデルのエコー画像の視認性調整方法および超音波ガイド法の穿刺手技訓練方法
US20220304922A1 (en) * 2019-09-10 2022-09-29 Norwegian University Of Science And Technology (Ntnu) Ultrasound phantom

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011209691A (ja) * 2010-03-09 2011-10-20 Canon Inc 光音響整合材及び人体組織模擬材料
JP2018011772A (ja) * 2016-07-21 2018-01-25 キヤノン株式会社 ファントムおよび評価方法
JP2020166187A (ja) * 2019-03-29 2020-10-08 国立大学法人東北大学 医療処置の訓練用皮膚モデル、医療処置の訓練用皮膚モデルのエコー画像の視認性調整方法および超音波ガイド法の穿刺手技訓練方法
US20220304922A1 (en) * 2019-09-10 2022-09-29 Norwegian University Of Science And Technology (Ntnu) Ultrasound phantom

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