WO2024052665A1 - Combinaison herbicide, composition et procédé de lutte contre les mauvaises herbes l'utilisant - Google Patents

Combinaison herbicide, composition et procédé de lutte contre les mauvaises herbes l'utilisant Download PDF

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Publication number
WO2024052665A1
WO2024052665A1 PCT/GB2023/052295 GB2023052295W WO2024052665A1 WO 2024052665 A1 WO2024052665 A1 WO 2024052665A1 GB 2023052295 W GB2023052295 W GB 2023052295W WO 2024052665 A1 WO2024052665 A1 WO 2024052665A1
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Prior art keywords
combinations
napropamide
glufosinate
combination
salts
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PCT/GB2023/052295
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English (en)
Inventor
Giuvan LENZ
Jessica Ferreira Lourenco LEAL
Ganesh Rao
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Upl Mauritius Limited
Upl Europe Ltd.
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Publication of WO2024052665A1 publication Critical patent/WO2024052665A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • A01N57/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds containing nitrogen-to-oxygen bonds
    • A01N33/18—Nitro compounds
    • A01N33/20—Nitro compounds containing oxygen or sulfur attached to the carbon skeleton containing the nitro group
    • A01N33/22—Nitro compounds containing oxygen or sulfur attached to the carbon skeleton containing the nitro group having at least one oxygen or sulfur atom and at least one nitro group directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
    • A01N39/02—Aryloxy-carboxylic acids; Derivatives thereof

Definitions

  • the present invention relates to a combination of herbicides. More specifically, the present invention relates to a herbicidal combination comprising L-glufosinate, salts, esters, or combinations thereof, and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof. The present invention also relates to a herbicidal composition comprising L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide; and a method of controlling weeds using the same.
  • Herbicides are pesticides useful for killing or controlling unwanted plants. Generally, there are two kinds of herbicides - selective and non-selective herbicides. Selective herbicides kill certain target weeds while leaving the desired crop relatively unharmed, while non-selective herbicides kill both the weeds and the crops. Profitable crop production depends on effective weed control. The weeds can reduce crop yields by competing for water, sunlight, and nutrients. In today’s crop production systems, starting off with a good bum-down program is necessary as it helps to achieve maximum initial crop growth and reduce weed interference during early stages of the crop cycle. Since the weed-crop competition is critical during the early stages of crop cycle, the weed interference at an early stage has a direct impact on the yield of the crop.
  • An effective weed control can be achieved by usage of herbicides appropriately.
  • the activity of herbicides can be enhanced in various ways to achieve the maximum benefit.
  • One of the ways is to use combinations of herbicides. However, identifying appropriate combinations, their agrochemical application rates, and ratio of the combinations is essential to achieve efficacious control. Also, the selection of a particular formulation type is more cumbersome for an agrochemical combination. Thus, herbicides play an important role for weed control in maximizing crop yield. Also, applying combinations of herbicidal compounds may enhance the herbicidal effectiveness.
  • agrochemicals have chiral structures. For example, about 30% of currently registered pesticidal active ingredients contain one or more chiral structures. Some chiral herbicides are sold as purified, optically active isomers, but for economic reasons, many others are still used as racemates. Different enantiomers of chiral herbicides can have different enantioselective activities on target weeds and different toxic effects on non-target organisms because of their enantioselective interactions with enzymes and biological receptors in organisms but the herbicidal selectivity of a specific isomer is not predictable.
  • the enantiomers of chiral substances have the same physicochemical properties, their biochemical activities can be different because biochemical processes usually show high stereo or enantioselectivity.
  • the “active” enantiomer of a chiral chemical may have the desired effect on a target species, whereas the other enantiomer may not. It is advisable to use only the biologically active enantiomers, thereby reducing the total amount of chemical pollutants released into the environment.
  • Glufosinate also known as phosphinothricin; DL-homoalanin-4- yl(methyl)phosphinic acid
  • phosphinothricin DL-homoalanin-4- yl(methyl)phosphinic acid
  • ammonium salt glufosinate-ammonium
  • Glufosinate-ammonium is widely used as a non-selective herbicide and is an active ingredient of many commercial herbicide formulations.
  • Glufosinate is a contact herbicide and is taken up by the plant primarily through the leaves. There is no uptake from the soil through the roots, presumably because of the rapid degradation of glufosinate by soil micro-organisms. There is also limited translocation of glufosinate within the plant.
  • Glufosinate has a wide spectrum of activity encompassing monocotyledonous and dicotyledonous species. However, due to its limited systemic action, there is no enduring effect on perennial weeds. Hoechst et al., in 1991, reported examples of weed species which are either not combated, or only weakly combated by glufosinate such as Viola arvensis, Bromus spp., Lolium spp., Agropyron repens and Urtica urens. Moreover, weeds emerging after herbicide application are not affected. Furthermore, L-Glufosinate has herbicidal activity, which is about four times that of glyphosate, about twice that of paraquat, and more than about twice that of racemic glufosinate (DL-glufosinate).
  • Napropamide is a selective systemic herbicide absorbed by roots and translocated acropetally. It inhibits root development and growth. Napropamide is a chiral molecule that exists in the R-and S-forms. Napropamide-M is the biologically active R-isomer and is up to about 8 times more active than the L-isomer (S-form) and about 1.7 to 2 times more active than the racemic mixture.
  • the present invention provides a herbicidal combination comprising L- glufosinate, salts, esters, or combinations thereof, and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof.
  • L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof are combined in a weight ratio ranging from about 1 : 100 to about 100: 1.
  • the present invention provides a herbicidal composition
  • a herbicidal composition comprising L-glufosinate, salts, esters, or combinations thereof, at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof, and at least one agrochemically acceptable excipient.
  • the present invention provides a process of preparing a herbicidal composition comprising L-glufosinate, salts, esters, or combinations thereof, at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof, and at least one agrochemically acceptable excipient.
  • the present invention provides use of a herbicidal combination comprising L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof for controlling or killing weeds.
  • Another aspect of the invention provides a method of controlling weeds, the method comprising applying to a plant or a locus thereof, a synergistic herbicidal combination comprising L-glufosinate, salts, esters, or combinations thereof, and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof.
  • herbicide as used herein means an active ingredient that kills, controls or otherwise adversely modifies the growth of plants.
  • a herbicidally effective or vegetation controlling amount is an amount of active ingredient that causes a “herbicidal effect”, i.e., an adversely modifying effect and includes deviations from natural development, killing, regulation, desiccation, retardation, and methods known to a person skilled in the art.
  • plants and “vegetation” include, but are not limited to, germinant seeds, emerging seedlings, plants emerging from vegetative propagules, and established vegetation.
  • weed refers to unwanted vegetation and includes any plant which grows where it is not wanted, including pesticide resistant plants.
  • the term “weed” refers to plants which grow in locations in which they are not desired.
  • a “weed” is a plant in which in the context of a crop is undesirable due to competition for water, nutrients, sunlight, soil, etc.
  • the term may also refer to crop plants which are undesirable at a location.
  • the terms “undesirable vegetation”, “undesirable species”, “undesirable plants”, “harmful plants”, “undesirable weeds”, “harmful weeds” or “weed” are synonyms.
  • the combinations/compositions of the present invention are applied to the targeted weed or to their locus or to the crop/plant.
  • locus shall denote the vicinity of a desired crop in which weed control, typically selective weed control is desired.
  • the locus includes the vicinity of desired crop plants wherein the weed infestation has either emerged or is yet to emerge.
  • crop shall include a multitude of desired crop plants or an individual crop plant growing at a locus.
  • the said locus could be a weed, an area adjacent to the weed, soil adapted to support growth of the weed, a root of the weed and/or foliage of the weed.
  • the phrase comprising may be replaced by the phrases “consisting of’ or “consisting essentially of’ or “consisting substantially of’.
  • the combination or composition described includes or comprises or consists of or consists essentially of or consists substantially of the specific components recited therein, to the exclusion of other fungicides or insecticide or plant growth promoting agents, adjuvants, or excipients not specifically recited therein.
  • g a.i./L denotes the concentration of the respective active ingredient in “grams” present “per litre” of the composition.
  • the terms “g a.i./L”, “g a.i./L” and “g/L” may be used interchangeably.
  • g a.i./ha denotes the concentration of the respective active ingredient in “grams” applied “per hectare” of the crop field.
  • g ai/ha g a.i./ha
  • g/ha g/ha
  • An effective weed control can be achieved by usage of herbicides appropriately.
  • the activity of herbicides can be enhanced in various ways to achieve the maximum benefit.
  • One of the ways is to use herbicides with different herbicidal combinations. However, identifying appropriate combinations, their agrochemical application rates, and ratio of the combinations is essential to achieve efficacious control, which is not straight forward.
  • the present invention provides a method for partially or completely controlling harmful weeds with a combination of two or more herbicides.
  • L-glufosinate or “L-isomer of glufosinate” are synonymous and interchangeable and also includes salts and ester forms of L- glufosinate.
  • the L-isomer of glufosinate is a structural analogue of glutamate and, therefore, is a competitive inhibitor of the enzyme glutamine synthetase (GS) of bacteria and plants.
  • the L-isomer, also called ass L-enantiomer, of glufosinate acts by inhibition of glutamine synthetase thereby causing accumulation of toxic levels of ammonium ion and indirectly stopping photosynthesis.
  • phosphinothricin It is also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid.
  • the term can generically refer to any form of L-glufosinate such as solvates, hydrates, esters, anhydrous form, polymorph forms, pseudo polymorph forms, amorphous form or mixture thereof, and sodium, potassium or ammonium salts.
  • the term may also refer to an isomeric (racemic) mixture of L-glufosinate, D- glufosinate and salts thereof, wherein the content of L-glufosinate in the mixture is about 70% or greater, preferably about 80% or greater and more preferably about 90% or greater.
  • the ratio of L-glufosinate: D-glufosinate can be in the range from about 95:5 to about 99.9:0.1.
  • L-glufosinate, salts, esters, or combinations thereof is a herbicide of the organophosphate herbicide class. According to an embodiment, L-glufosinate, salts, esters, or combinations thereof is a herbicide of the glutamine synthetase inhibitor class.
  • napropamide, napropamide-M, or combinations thereof are herbicides of the amide herbicide class.
  • napropamide, napropamide-M, or combinations thereof are herbicides of the very long chain fatty acid (VLCFA) inhibitor class.
  • the said herbicidal combination comprising L- glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof is a synergistic combination.
  • the herbicidal activity of a combination exceeds the total activities of the individual active compounds.
  • the activity will be greater than the sum of the single active compound alone.
  • Such herbicidal combinations are synergistic for controlling one or more weeds.
  • the use of the herbicidal combinations/compositions according to the present invention provides for excellent herbicidal effectiveness against a broad spectrum of economically important mono-and dicotyledonous annual weeds and perennial weeds.
  • the present invention provides a synergistic herbicidal combination comprising:
  • the salt comprises an inorganic salt of L-glufosinate.
  • the inorganic salt of L-glufosinate is selected from the group comprising L-glufosinate ammonium, L-glufosinate sodium, L-glufosinate potassium, or combinations thereof.
  • the inorganic salts of L-glufosinate can be selected from the group comprising monosodium salt, disodium salt, monopotassium salt, dipotassium salt, calcium salt, ammonium salt, -NH3(CH3) + salt, -NH 2 (CH 3 ) 2+ salt, -NH(CH 3 ) 3+ salt, -NH(CH 3 ) 2 (C 2 H 4 OH) + salt, - NH 2 (CH3)(C 2 H4OH) + salt, or combinations thereof.
  • L-glufosinate-ammonium also called glufosinate-P-ammonium
  • 2S ammonium
  • L-glufosinate-sodium also called glufosinate-P-sodium
  • L-glufosinate-potassium also called glufosinate-P -potassium
  • the L-glufosinate salt is L-glufosinate ammonium.
  • the L-glufosinate salt is L-glufosinate sodium.
  • the L-glufosinate salt is L-glufosinate potassium.
  • the present disclosure provides a synergistic herbicidal combination comprising L-glufosinate ammonium and at least one additional herbicide.
  • the present disclosure provides a synergistic herbicidal combination comprising L-glufosinate ammonium and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof.
  • L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof are combined in a weight ratio from about 1000: 1 to about 1: 1000. Specifically, the two actives are combined in a weight ratio from about 750: 1 to about 1 :750. According to an embodiment, L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof are combined in a weight ratio from about 500: 1 to about 1 :500.
  • L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof are combined in a weight ratio from about 250: 1 to about 1 :250. According to an embodiment, L- glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof are combined in a weight ratio from about 100: 1 to about 1 : 100. According to an embodiment, L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof are combined in a weight ratio from about 75: 1 to about 1 :75.
  • L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof are combined in a weight ratio from about 50: 1 to about 1 :50. According to an embodiment, L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof are combined in a weight ratio from about 25: 1 to about 1 :25. According to an embodiment, L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof are combined in a weight ratio from about 10: 1 to about 1 : 10. According to an embodiment, L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof are combined in a weight ratio from about 5: 1 to about 1:5.
  • the present disclosure provides a method of controlling weeds at a locus thereof, by applying a herbicidal combination comprising L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof, wherein a weight ratio of L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide ranges from about 1:25 to about 25: 1.
  • the present disclosure provides a method of controlling weeds at a locus thereof, by applying a herbicidal combination comprising L-glufosinate ammonium and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof, wherein a weight ratio of L-glufosinate ammonium and at least one additional herbicide ranges from about 1 : 5 to about 5: 1. In a preferred embodiment, the weight ratio of L-glufosinate ammonium to napropamide is about 1 : 1.6.
  • the present disclosure provides a synergistic herbicidal composition comprising L-glufosinate ammonium and at least one additional herbicide.
  • the present disclosure provides a synergistic herbicidal composition
  • a synergistic herbicidal composition comprising L-glufosinate ammonium and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof.
  • the herbicidal combination or the herbicidal composition of the present invention further comprises a second additional herbicide.
  • Non-limiting examples of the second additional herbicide comprise 2,4-D, anisiflupurin, acetochlor, aclonifen, amicarbazone, halauxifen, halauxifen-methyl, florpyrauxifen, amidosulfuron, aminocyclopyrachlor, aminopyralid, aminotriazole, ammonium thiocyanate, anilofos, asulam, azimsulfnron, atrazine, beflubutamid, benazolin, benfuresate, bensulfuron-methyl, bentazon-sodium, benzofenap, bifenox, bixlozone, benquitrione, bipyrazone, bispyribacsodium, bromobutide, bromacil, bromoxynil, butachlor, butafenacil, butralin, butroxydim, carbetamide, cafenstrole, carfentrazone, carfentrazone-ethyl
  • the second additional herbicide is oxyfluorfen.
  • Oxyfluorfen is a herbicide of the diphenyl ether herbicide class. Oxyfluorfen also belongs to the protoporphyrinogen oxidase inhibitor class.
  • the herbicidal combination or the herbicidal composition of the present invention further comprises a second additional herbicide selected from oxyfluorfen.
  • an embodiment of the present invention presents a herbicidal combination comprising:
  • the present invention presents a herbicidal combination comprising:
  • the present invention presents a herbicidal combination comprising:
  • the present invention presents a herbicidal composition
  • a herbicidal composition comprising:
  • the second additional herbicide is 2,4-D.
  • the present invention presents a herbicidal composition
  • a herbicidal composition comprising:
  • the second additional herbicide is amicarbazone.
  • the present invention presents a herbicidal composition
  • a herbicidal composition comprising:
  • the second additional herbicide is halauxifen.
  • the present invention presents a herbicidal composition
  • a herbicidal composition comprising:
  • the second additional herbicide is halauxifen-m ethyl.
  • the present invention presents a herbicidal composition
  • a herbicidal composition comprising:
  • the total amount of L-glufosinate, salts, esters, or combinations thereof in the composition may typically be in the range of about 0.1% to about 99% by weight of total weight of the composition.
  • the total amount of napropamide-M or napropamide in the composition may be in the range of about 0.1% to about 99% by weight of total weight of the composition.
  • the total amount of the second additional herbicide in the composition may be in the range of about 0.1% to about 99% by weight of total weight of the composition.
  • L-glufosinate, salts, esters, or combinations thereof, at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof, and the second additional herbicide in the combination or composition of the present invention may be admixed in a weight ratio of about 1000: 1 : 1 to about 1: 1000: 1000.
  • the herbicides L-glufosinate, salts, esters, or combinations thereof, at least one additional herbicide selected from napropamide, napropamide- M, or combinations thereof, and the second additional herbicide in the combination or composition of the present invention may be admixed in a weight ratio of about 100: 1 : 1 to about 1 : 100: 100.
  • the herbicides L-glufosinate, salts, esters, or combinations thereof, at least one additional herbicide selected from napropamide, napropamide- M, or combinations thereof, and the second additional herbicide in the combination or composition of the present invention may be admixed in a weight ratio of about 25: 1: 1 to about 1 :25:25.
  • the herbicides L-glufosinate, salts, esters, or combinations thereof, at least one additional herbicide selected from napropamide, napropamide- M, or combinations thereof, and the second additional herbicide in the combination or composition of the present invention may be admixed in a weight ratio of about 10: 1: 1 to about 1 : 10: 10.
  • the herbicides L-glufosinate, salts, esters, or combinations thereof, at least one additional herbicide selected from napropamide, napropamide- M, or combinations thereof, and the second additional herbicide in the combination or composition of the present invention may be admixed in a weight ratio of about 5: 1 : 1 to about 1 :5:5.
  • L-glufosinate ammonium, napropamide and oxyfluorfen are present in a weight ratio of about 1 : 1.6:0.85. According to an embodiment, L-glufosinate is added as its ammonium salt to the composition.
  • the amount of L-glufosinate, salts, esters, or combinations thereof in the combinations or compositions of the present invention may range from about 1 g a.i./L to about 1000 g a.i./L. In an embodiment, the amount of L- glufosinate, salts, esters, or combinations thereof in the combinations or compositions of the present invention may range from about 10 g a.i./L to about 1000 g a.i./L. In an embodiment, the amount of L-glufosinate, salts, esters, or combinations thereof in the combinations or compositions of the present invention may range from about 50 g a.i./L to about 1000 g a.i./L.
  • the amount of L-glufosinate, salts, esters, or combinations thereof in the combinations or compositions of the present invention may range from about 100 g a.i./L to about 1000 g a.i./L. In an embodiment, the amount of L-glufosinate, salts, esters, or combinations thereof in the combinations or compositions of the present invention may range from about 100 g a.i./L to about 400 g a.i./L. In an embodiment, the amount of L-glufosinate, salts, esters, or combinations thereof in the combinations or compositions of the present invention may range from about 180 g a.i./L to about 380 g a.i./L. In an embodiment, the amount of L-glufosinate, salts, esters, or combinations thereof in the combinations or compositions of the present invention may range from about 250 g a.i./L to about 300 g a.i./L.
  • L-glufosinate, salts, esters, or combinations thereof is present in an amount of about 280 g a.i./L.
  • L-glufosinate, salts, esters, or combinations thereof is present in an amount of about 200 g a.i./L. In one preferred embodiment, in combinations or compositions of the present invention, L-glufosinate, salts, esters, or combinations thereof is present in an amount of about 150 g a.i./L.
  • the amount of napropamide or napropamide-M in the combinations or compositions of the present invention may range from about 1 g a.i./L to about 2000 g a.i./L. In an embodiment, the amount of napropamide or napropamide-M in the combinations or compositions of the present invention may range from about 10 g a.i./L to about 2000 g a.i./L. In an embodiment, the amount of napropamide or napropamide-M in the combinations or compositions of the present invention may range from about 50 g a.i./L to about 2000 g a.i./L.
  • the amount of napropamide or napropamide-M in the combinations or compositions of the present invention may range from about 100 g a.i./L to about 2000 g a.i./L. In an embodiment, the amount of napropamide or napropamide-M in the combinations or compositions of the present invention may range from about 100 g a.i./L to about 1000 g a.i./L. In an embodiment, the amount of napropamide or napropamide-M in the combinations or compositions of the present invention may range from about 100 g a.i./L to about 800 g a.i./L.
  • napropamide or napropamide-M is present in an amount of about 450 g a.i./L.
  • the amount of second additional herbicide in the combinations or compositions of the present invention may range from about 100 g a.i./L to about 800 g a.i./L.
  • the amount of second additional herbicide in the combinations or compositions of the present invention may range from about 100 g a.i./L to about 700 g a.i./L. In an embodiment, the amount of second additional herbicide in the combinations or compositions of the present invention may range from about 100 g a.i./L to about 500 g a.i./L.
  • the amount of second additional herbicide in the combinations or compositions of the present invention may range from about 200 g a.i./L to about 400 g a.i./L.
  • oxyfluorfen is present in an amount of about 240 g a.i./L.
  • the herbicidal combination comprises:
  • said composition further comprises at least one agrochemically acceptable excipient.
  • a herbicidal composition comprising:
  • composition further comprises a second additional herbicide selected from oxyfluorfen.
  • a herbicidal composition comprising:
  • the agrochemically acceptable excipients/carriers/additives comprise at least one co-solvent(s), surfactant(s), water, colorant(s), dispersant(s), emulsifier(s), thickener(s), antifreeze agent(s), biocide(s), anti-foam agent(s), stabilize ⁇ s), wetting agent(s), or combinations thereof.
  • the surfactant(s) may be selected from non-ionic, anionic, cationic surfactants, or combinations thereof.
  • non-ionic surfactants comprise polyarylphenol polyethoxy ethers, polyalkylphenol polyethoxy ethers, polyglycol ether derivatives of saturated fatty acids, polyglycol ether derivatives of unsaturated fatty acids, polyglycol ether derivatives of aliphatic alcohols, polyglycol ether derivatives of cycloaliphatic alcohols, fatty acid esters, of polyoxyethylene sorbitan, alkoxylated vegetable oils, alkoxylated acetylenic diols, polyalkoxylated alkylphenols, fatty acid alkoxylates, sorbitan alkoxylates, sorbitol esters, C8-C22 alkyl or alkenyl polyglycosides, polyalkoxy styrylaryl ethers, alkylamine oxides, block copolymer ethers, polyalkoxylated fatty glyceride, polyalkylene glycol ethers, polyalkoxy
  • anionic surfactants comprise alcohol sulfates, alcohol ether sulfates, alkylaryl ether sulfates, alkylaryl sulfonates such as alkylbenzene sulfonates and alkylnaphthalene sulfonates and salts thereof, alkyl sulfonates, mono- or di-phosphate esters of polyalkoxylated alkyl alcohols or alkylphenols, mono- or di-sulfosuccinate esters of C12-C15 alkanols or polyalkoxylated C12-C15 alkanols, alcohol ether carboxylates, phenolic ether carboxylates, polybasic acid esters of ethoxylated polyoxyalkylene glycols consisting of oxybutylene or the residue of tetrahydrofuran, sulfoalkylamides and salts thereof such as N-methyl-N-oleoyltau
  • the cationic surfactants comprise alkanol amides of Cs-Cis fatty acids and Cs-Cis fatty amine polyalkoxylates, Cio-Cis alkyldimethylbenzylammonium chlorides, coconut alkyldimethylaminoacetic acids, and phosphate esters of Cs-Cis fatty amine polyalkoxylates, or combinations thereof.
  • the emulsifier(s) which can be advantageously employed herein can be readily determined by those skilled in the art and comprise various nonionic, anionic, cationic and amphoteric emulsifiers, or a blend of two or more emulsifiers.
  • nonionic emulsifiers useful in preparing emulsifiable concentrates include the polyalkylene glycol ethers and condensation products of alkyl and aryl phenols, aliphatic alcohols, aliphatic amines or fatty acids with ethylene oxide, propylene oxides such as the ethoxylated alkyl phenols and carboxylic esters solubilized with the polyol or polyoxyalkylene.
  • Cationic emulsifiers include quaternary ammonium compounds and fatty amine salts.
  • Anionic emulsifiers include the oil-soluble salts (e.g., calcium) of alkylaryl sulfonic acids, oil-soluble salts or sulfated polyglycol ethers and appropriate salts of phosphated polyglycol ether, or combinations thereof.
  • the colorant(s) comprise iron oxide, titanium oxide and Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestuffs or metal phthalocyanine dyestuffs, and trace elements, such as salts of iron, manganese, boron, copper, cobalt, molybdenum, zinc, or combinations thereof.
  • organic dyestuffs such as alizarin dyestuffs, azo dyestuffs or metal phthalocyanine dyestuffs
  • trace elements such as salts of iron, manganese, boron, copper, cobalt, molybdenum, zinc, or combinations thereof.
  • a thickener or binder which may be selected from the group comprising molasses, granulated sugar, alginates, karaya gum, jaguar gum, tragacanth gum, polysaccharide gum, mucilage, xanthan gum, or combinations thereof.
  • the binder may be selected from the group comprising silicates such as magnesium aluminium silicate, polyvinyl acetates, polyvinyl acetate copolymers, polyvinyl alcohols, polyvinyl alcohol copolymers, celluloses, including ethylcelluloses and methylcelluloses, hydroxymethyl celluloses, hydroxypropylcelluloses, hydroxymethylpropylcelluloses, polyvinylpyrolidones, dextrins, malto-dextrins, polysaccharides, fats, oils, proteins, gum arabics, shellacs, vinylidene chloride, vinylidene chloride copolymers, calcium lignosulfonates, acrylic copolymers, starches, polyvinylacrylates, zeins, gelatin, carboxymethylcellulose, chitosan, polyethylene oxide, acrylimide polymers and copolymers, polyhydroxyethyl acrylate, methylacrylimide monomers, alginate,
  • an antifreeze agent(s) added to the composition may be alcohols selected from the group comprising ethylene glycol, 1,2-propylene glycol, 1,3 -propylene glycol, 1,2-butanediol, 1,3 -butanediol, 1,4-butanediol, 1,4- pentanediol, 3-methyl-l,5-pentanediol, 2,3-dimethyl-2,3-butanediol, trimethylol propane, mannitol, sorbitol, glycerol, pentaerythritol, 1,4-cyclohexanedimethanol, xylenol, bisphenols such as bisphenol A or the like.
  • ether alcohols such as diethylene glycol, triethylene glycol, tetraethylene glycol, polyoxyethylene or polyoxypropylene glycols of molecular weight up to about 4000, diethylene glycol monomethylether, diethylene glycol monoethylether, triethylene glycol monomethylether, butoxy ethanol, butylene glycol monobutylether, dipentaerythritol, tri pentaerythritol, tetrapentaerythritol, diglycerol, triglycerol, tetraglycerol, pentaglycerol, hexaglycerol, heptaglycerol, octaglycerol, or combinations thereof.
  • diethylene glycol monomethylether diethylene glycol monoethylether
  • triethylene glycol monomethylether butoxy ethanol
  • butylene glycol monobutylether dipentaerythritol, tri pentaerythritol, tetrapentaerythri
  • the biocide(s) or preservative(s) comprise benzothiazoles, l,2-benzisothiazolin-3-one, sodium dichloro-s-triazinetrione, sodium benzoate, potassium sorbate, l,2-phenyl-isothiazolin-3-one, inter chloroxylenol paraoxybenzoate butyl, or combinations thereof.
  • the antifoam agent(s) comprise polydimethoxysiloxane, polydimethylsiloxane, alkyl poly acrylates, castor oil, fatty acids, fatty acid esters, fatty acid sulfates, fatty alcohols, fatty alcohol esters, fatty alcohol sulfates, olive oil, mono and di glycerides, paraffin oil, paraffin wax, polypropylene glycol, silicone oil, vegetable and animal fats, sulfates of vegetable and animal fat, vegetable and animal oils, sulfates of vegetable and animal oils, vegetable and animal waxes, sulfates of vegetable and animal waxes, agents based on silicon or magnesium stearate, or combinations thereof.
  • the agrochemical formulation may also comprise one or more antioxidants.
  • the agrochemical formulation comprises an antioxidant.
  • Antioxidants are, for example, amino acids (e.g., glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazole and imidazole derivatives (e.g., urocanic acid), peptides, such as, for example, D,L-camosine, D-carnosine, L-camosine and derivatives thereof (e.g., anserine), carotenoids, carotenes (e.g., a- carotene, P-carotene, lycopene) and derivatives thereof, lipoic acid and derivatives thereof (e.g., dihydrolipoic acid), aurothioglucose, propylthiouracil and further thio compounds (e.g., thioglycerol, thiosorbitol, thiog
  • amino acids
  • the examples of solvents are water, aromatic solvents (for example xylene), paraffins (for example mineral oil fractions such as kerosene or diesel oil), coal tar oils and oils of vegetable or animal origin, aliphatic, cyclic and aromatic hydrocarbons, for example toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalenes or their derivatives, alcohols (for example methanol, butanol, pentanol, benzyl alcohol, cyclohexanol), ketones (for example cyclohexanone, gamma-butyrolactone), pyrrolidones, N-Methyl-2- pyrrolidone (NMP), N-Ethyl-2 pyrrolidone (NEP), N-Octyl-2-pyrrolidone (NOP), acetates (glycol diacetate), glycols, fatty acid dimethyl
  • solvent mixtures may also be used.
  • exemplary surfactants comprise alkali metal, alkaline earth metal and ammonium salts of lignosulfonic acid, naphthalene sulfonates, phenolsulfonic acid, dibutylnaphthalenesulfonic acid, alkylarylsulfonates, alkyl sulfates, alkyl sulfonates, fatty alcohol sulfates, fatty acids and sulfated fatty alcohol glycol ethers, furthermore condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensates of naphthalene or of naphthalene sulfonic acid with phenol and formaldehyde, polyoxyethylene octyl phenol ethers, ethoxylated isooctylphenol, octyl phenol, nonylphenol, alkylphenol polyglycol ethers,
  • examples of carriers comprise mineral earths such as silica gels, silicates, talc, kaolin, attaclay, attapulgite, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, fertilizers, such as, for example, ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, and products of vegetable origin, such as cereal meal, tree bark meal, wood meal and nutshell meal, cellulose powders, polyvinylpyrrolidone and other solid carriers, or combinations thereof.
  • mineral earths such as silica gels, silicates, talc, kaolin, attaclay, attapulgite, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials
  • present compositions may further comprise at least safener.
  • the safener can be selected from the group comprising isoxadifen-ethyl, cloquintocet-mexyl, mefenpyr-diethyl, naphthalic anhydride, oxabetrinil, benzenesulfonamide, N-(aminocarbonyl)-2-chlorobenzene sulfonamide (2-CBSU), daimuron, di chloroacetamide, dicyclonon, fenchlorazole- ethyl, fenclorim, fluxofenim, Dichloroacetamide safeners (e.g., AD-67, benoxacor, dichlormid, and furilazole), naphthopyranone, naphthalic anhydride (NA), oxime, phenylpyrimidine, phenylurea, phenyl pyrazoles compounds, naphthalic anhydride, cyometrinil, flurazole, dime
  • the composition may be present in any agrochemically suitable form for storage and application to the ground.
  • the compositions may be produced by mixing the actives in the composition with an inert carrier and adding surfactants and other adjuvants and carriers as needed and formulated into solid or liquid formulations, comprising wettable powders (WP), granules (GR), dusts, soluble (liquid) concentrates (SL), suspension concentrates (SC), oil in water emulsion (EW), water in oil emulsion (EO), emulsifiable concentrates (EC), capsule suspensions (CS), mixed formulation of CS and SC (ZC) formulations, oil dispersions (OD), other known formulation types, or combinations thereof.
  • WP wettable powders
  • GR granules
  • dusts dusts
  • SL soluble (liquid) concentrates
  • SC suspension concentrates
  • EW oil in water emulsion
  • EO oil in oil emulsion
  • EC emulsifiable concentrates
  • herbicidal combinations and compositions of the present invention can be in any conventional agriculturally useful form, for example, in the form of a ready-to- use formulation, or in the form of a tank mix.
  • the herbicidal actives may be formulated as a premix product or a ready-to-use product.
  • the herbicidal actives may be tank-mixed at the time of application.
  • the method comprises applying the present combinations or compositions simultaneously, that is jointly or separately, or in succession.
  • constituents of the combination of the present invention may be tank mixed and applied or sprayed at the locus of the infection or may be alternatively mixed with surfactants and/or any other agrochemically acceptable excipients and then applied.
  • the constituents of the combination of the present invention may be applied in such quick succession in any order to form the desired mix at the locus of application.
  • the constituents of the composition of the present invention may be used for foliar application, ground or applications to plant propagation materials.
  • Each individual composition may comprise one or more agrochemically acceptable excipient/ingredients.
  • the resulting combination or tank-mix of the composition comprising L-glufosinate, salts, esters, or combinations thereof and the composition comprising napropamide or napropamide-M provides a synergistic effect in controlling the weeds.
  • the tank-mix combination may further comprise a composition comprising a second additional herbicide.
  • compositions of the present invention further comprise at least one additional agrochemical/pesticide.
  • pesticides include, but are not limited to, herbicides, fungicides, miticides, larvicides, avicides, insecticides, nematicides and rodenticides.
  • compositions may further comprise at least one safener.
  • the safener can be selected from the group comprising isoxadifen-ethyl, cloquintocet-mexyl, mefenpyr-diethyl, naphthalic anhydride, oxabetrinil, benzenesulfonamide, N-(aminocarbonyl)-2-chlorobenzene sulfonamide (2-CBSU), daimuron, di chloroacetamide, dicyclonon, fenchlorazole- ethyl, fenclorim, fluxofenim, Dichloroacetamide safeners (e.g., AD-67, benoxacor, dichlormid, and furilazole), naphthopyranone, naphthalic anhydride (NA), oxime, phenylpyrimidine, phenylurea, phenyl pyrazoles compounds, naphthalic anhydride (NA), oxi
  • a process for preparing a composition comprising L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof.
  • the said process further involves addition of an agrochemically suitable excipient to the herbicidal actives.
  • it includes a second additional herbicide to the mixture.
  • the resulting composition is storage stable with improved shelf-life.
  • a herbicidal combination for controlling weeds comprising:
  • the use of the herbicidal combination further comprising a second additional herbicide selected from oxyfluorfen.
  • a herbicidal combination for controlling weeds comprising:
  • composition comprising L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof to control, eradicate or prevent weed growth.
  • the composition further comprises a second additional herbicide.
  • the combinations and compositions of the present invention can be used in agricultural lands such as fields, paddy fields, lawns and orchards or in non- agricultural lands.
  • the present invention may be used to control weeds in agricultural lands for cultivating the crops without any phytotoxicity to the crops.
  • crops on which the combinations and compositions of the present invention may be used include but are not limited to corn, rice, wheat, barley, rye, oat, sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower, sugar cane, tobacco, etc.; vegetables: solanaceous vegetables such as eggplant, tomato, pimento, pepper, potato, etc., cucurbit vegetables such as cucumber, pumpkin, zucchini, water melon, melon, squash, etc., cruciferous vegetables such as radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc., asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc, liliaceous vegetables such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, parsley, celery, parsnip, etc., chenopodiaceous vegetables such as spinach, Swiss chard, etc., la
  • berries such as blueberry, cranberry, blackberry, raspberry, etc., grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc. , trees other than fruit trees; tea, mulberry, flowering plant, trees such as ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus, poplar, Judas tree, Liquidambar formosana, plane tree, zelkova, Japanese arborvitae, fir wood, hemlockjuniper, Pinus, Picea, and Taxus cuspidate, etc.
  • the combinations and/or compositions of the present invention are used to control weeds in crops selected from the group of drybeans, sunflower, sorghum, rice, canola, cereals, peanuts, pulses, and sugarcane.
  • the combinations and/or compositions of the present invention are used to control weeds in pasture, plantations, trees, vines, and nuts.
  • the present invention provides a method for controlling weeds by applying a herbicidal combination comprising: (a) L-glufosinate, salts, esters, or combinations thereof; and
  • a method for controlling weeds at a locus comprising applying to the said locus, a combination comprising L- glufosinate, salts, esters, or combinations thereof, and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof.
  • said combination is synergistic.
  • a method of controlling weeds at a locus comprising applying to the said locus, a composition comprising L- glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof.
  • a method of controlling weeds at a locus comprising applying to the said locus, a combination or a composition comprising L-glufosinate, salts, esters, or combinations thereof, at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof, and a second additional herbicide.
  • the herbicidal combination is applied jointly, or separately, or sequentially, or simultaneously to a plant or a locus thereof to control from about 70% to about 100% of the weeds.
  • the present invention provides L-glufosinate, salts, esters, or combinations thereof in combination with at least one additional herbicide, wherein the combination controls from about 70% to about 100% of the weeds.
  • the present invention provides L-glufosinate, salts, esters, or combinations thereof applied at a rate of about 150 g a.i./ha, in combination with at least one additional herbicide applied at a rate of about 675 g a.i./ha, wherein the combination controls from about 70% to about 100% of the weeds.
  • the present invention provides L-glufosinate applied at a rate of about 150 g a.i./ha, in combination with Napropamide applied at a rate of about 675 g a.i./ha for controlling Eleusine indica. wherein the combination controls from about 75% to about 85% of the weed at or within 7, 14, 21 to 28 days after application (DA A).
  • the present invention provides L-glufosinate applied at a rate of about 150 g a.i./ha, in combination with Napropamide applied at a rate of about 675 g a.i./ha for controlling Brachiaria decumbens. wherein the combination controls from about 90% to about 100% of the weed at or within 7, 14 to 21 days after application (DA A).
  • the present invention provides L-glufosinate ammonium applied at a rate of about 150 g a.i./ha, in combination with Napropamide applied at a rate of about 675 g a.i./ha for controlling Euphorbia heterophy I la. wherein the combination controls about 97% of the weed at or within 7, 14, 21 to 28 days after application (DAA).
  • the present invention provides L-glufosinate ammonium applied at a rate of about 150 g a.i./ha, in combination with Napropamide applied at a rate of about 675 g a.i./ha and Oxyfluorfen applied at a rate of about 430 g a.i./ha for controlling Euphorbia helerophylla, wherein the combination controls about 100% of the weed at or within 7, 14, 21 to 28 days after application (DAA).
  • DAA days after application
  • the present invention provides L-glufosinate ammonium applied at a rate of about 150 g a.i./ha, in combination with Napropamide applied at a rate of about 675 g a.i./ha and Oxyfluorfen applied at a rate of about 430 g a.i./ha for controlling Eleusine indica. wherein the combination controls from about 70.6 to about 80% of the weed at or within 7, 21 to 28 days after application (DAA).
  • DAA days after application
  • the present invention provides L-glufosinate ammonium applied at a rate of about 150 g a.i./ha, in combination with Napropamide applied at a rate of about 675 g a.i./ha and Oxyfluorfen applied at a rate of about 430 g a.i./ha for controlling Borreria verticilata, wherein the combination controls about 100% of the weed at or within 7 to 14 days after application (DAA).
  • DAA days after application
  • the present invention provides L-glufosinate ammonium applied at a rate of about 150 g a.i./ha, in combination with Napropamide applied at a rate of about 675 g a.i./ha and Oxyfluorfen applied at a rate of about 430 g a.i./ha for controlling Lolium species (ryegrass), wherein the combination controls about 80% of the weed at or within 28 days after application (DAA).
  • compositions of the present invention are used to control weeds in various agricultural crops.
  • weeds controlled by the compositions of the present invention include: Urticaceae weeds: Urtica urens
  • Polygonaceae weeds Polygonum convolvulus, Polygonum lapathifolium, Polygonum pensylvanicum, Polygonum persicaria, Polygonum longisetum, Polygonum aviculare, Polygonum arenastrum, Polygonum cuspidatum, Rumex japonicus, Rumex crispus, Rumex obtusifolius, Rumex acetosa; Portulacaceae weeds: Portulaca oleracea; Caryophyllaceae weeds: Stellaria media, Cerastium holosteoides, Cerastium glomeratum, Spergula arvensis, Silene gallica.
  • Molluginaceae weeds Mollugo verticillata; Chenopodiaceae weeds: Chenopodium album, Chenopodium ambrosioides, Kochia scoparia, Salsola kali, Atriplex spp.; Amaranthaceae weeds: Amaranthus retroflexus, Amaranthus viridis, Amaranthus lividus, Amaranthus spinosus, Amaranthus hybridus, Amaranthus palmeri, Amaranthus rudis, Amaranthus patulus, Amaranthus tuberculatos, Amaranthus blitoides, Amaranthus deflexus, Amaranthus quitensis, Alternanthera philoxeroides, Alternanthera sessilis, Alternanthera tenella; Papaveraceae weeds: Papaver rhoeas, Argemone Mexicana; Brassicaceae weeds:
  • Raphanus raphanistrum Raphanus sativus, Sinapis arvensis, Capsella bursa- pastoris, Brassica juncea, Brassica campestris, Descurainia pinnata, Rorippa islandica, Rorippa sylvestris, Thlaspi arvense, Myagrum rugosum, Lepidium virginicum, Coronopus didymus; Dinebra weeds: Dinebra Americana, Dinebra aquatic, Dinebra aristidoides, Dinebra bromoides, Dinebra calycina, Dinebra caudata, Dinebra chinensis, Dinebra chloride, Dinebra chondrosioides, Dinebra coerulescens, Dinebra cristata, Dinebra curtipendula, Dinebra decipiens, Dinebra divaricate, Dinebra divaricatissima, Dinebra dura, Dinebra guineensis, Dinebra hirs
  • Sterculiaceae weeds Waltheria indica; Violaceae weeds: Viola arvensis, Viola tricolor; Cucurbitaceae weeds: Sicyos angulatus, Echinocystis lobata, Momordica charantia; Lythraceae weeds: Lythrum salicaria; Apiaceae weeds: Hydrocotyle sibthorpioides; Sapindaceae weeds: Cardiospermum halicacabum; Primulaceae weeds: Anagallis arvensis; Asclepiadaceae weeds: Asclepias syriaca, Ampelamus albidus; Rubiaceae weeds: Galium aparine, Galium spurium var.
  • echinospermon Spermacoce latifolia, Richardia brasiliensis, Borreria alata, Borreria verticilata; Convolvulaceae weeds: Ipomoea alba, Ipomoea nil, Ipomoea hederacea, Ipomoea purpurea, Ipomoea hederacea var.
  • the weeds targeted by the combinations and compositions of the present invention are grassy weeds and broad-leaved weeds.
  • the combinations or the compositions according to the present invention may be used for bumdown application or fallow application.
  • the weed removal is not restricted to crop land or agricultural land only.
  • the weeds are targeted in non-agricultural areas such as, but not limited to, forestry, railways, infrastructure, amenities, companies, factories, roads and runways, sidewalks, highways, dividers, medians, pipelines, public utility lines, pumping stations, transformer stations, substations, around airports, electric utilities, commercial buildings, manufacturing plants, storage yards, rail yards, hangars, fence lines, parking lots, parkways, sedges, post-harvest crop lands, beneath greenhouse benches and around golf courses.
  • a method of application of a combination or a composition comprising L-glufosinate, salts, esters, or combinations thereof and at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof for control, eradication or prevention of weed growth.
  • the combination of the present invention maybe applied simultaneously as a tank mix or a premix formulation or may be applied sequentially.
  • the application may be made to the soil before emergence of the plants, either pre-planting or post planting.
  • the application may be made to the soil after emergence of the plants.
  • the application may be made as a foliar spray at different timings during crop development, with either one or more applications early or late post-emergence.
  • Herbicidal compositions according to the invention can also be incorporated into the soil before, during or after sowing seeds of a crop. These combinations as described above may be applied to the locus of the weeds, in an herbicidally effective amount.
  • L-glufosinate, salts, esters, or combinations thereof is applied to a target locus at a rate of about 1 to 3000 g a.i./ha. In an embodiment, L-glufosinate, salts, esters, or combinations thereof is applied to a target locus at a rate of about 1 to 2000 g a.i./ha. In an embodiment, L-glufosinate, salts, esters, or combinations thereof is applied to a target locus at a rate of about 1 to 1000 g a.i./ha.
  • L-glufosinate, salts, esters, or combinations thereof is applied to a target locus at a rate of about 1 to 500 g a.i./ha. In an embodiment, L-glufosinate, salts, esters, or combinations thereof is applied to a target locus at a rate of about 100 to 500 g a.i./ha. In an embodiment, L-glufosinate, salts, esters, or combinations thereof is applied to a target locus at a rate of about 100 to 300 g a.i./ha.
  • L-glufosinate ammonium is applied to a target locus at a rate of about 200 g a.i./ha. In an embodiment, L-glufosinate ammonium is applied to a target locus at a rate of about 150 g a.i./ha.
  • napropamide or napropamide-M is applied to a target locus at a rate of about 1 to 3000 g a.i./ha. In an embodiment, napropamide or napropamide- M is applied to a target locus at a rate of about 1 to 2000 g a.i./ha. In an embodiment napropamide or napropamide-M is applied to a target locus at a rate of about 1 to 1000 g a.i./ha. In an embodiment napropamide or napropamide-M is applied to a target locus at a rate of about 200 g a.i./ha to about 800 g a.i./ha.
  • napropamide or napropamide-M is applied to a target locus at a rate of about 400 g a.i./ha to about 800 g a.i./ha. In an embodiment, napropamide or napropamide-M is applied to a target locus at a rate of about 675 g a.i./ha.
  • second additional herbicide is applied to a target locus at a rate of about 1 to 3000 g a.i./ha. In an embodiment, second additional herbicide is applied to a target locus at a rate of about 1 to 2000 g a.i./ha. In an embodiment, second additional herbicide is applied to a target locus at a rate of about 1 to 1000 g a.i./ha. In an embodiment, second additional herbicide is applied to a target locus at a rate of about 100 g a.i./ha to about 600 g a.i./ha.
  • oxyfluorfen is applied to a target locus at a rate of about 430 g a.i./ha.
  • the herbicidal combination comprises:
  • compositions of the present invention may be applied in any known ways or conventional methods known to a person skilled in art.
  • Non limiting examples of such methods are foliar spray, basal barking, stem injection, drill and fill method, axe cut method, cut stump, cut and swab, stem scraper, wick application and so forth.
  • the compositions of the present invention are used in the customary manner, for example by watering, spraying, atomizing, dusting or scattering.
  • compositions of the present invention can be applied to a locus by the use of conventional ground sprayers, granule applicators, watering (drenching), drip irrigation, spraying, atomizing, broadcasting, dusting, foaming, spreading-on, aerial methods of spraying, aerial methods of application, methods utilizing application using modem technologies such as, but not limited to, drones, robots and by other conventional means known to those skilled in the art.
  • the composition is applied at a rate that is ranging from 1 to 1000 kg/ha. Yet, the weight ratios of individual components can be varied within relatively wide ranges. Typically, there are 1 : 1000 to 1000: 1 part by weight of the active compounds.
  • the combinations of the present invention may be developed as a pre-mix composition or a kit of parts such that individual actives may be mixed before applying.
  • an embodiment of the present invention provides a kit-of-parts comprising a component of L-glufosinate, salts, esters, or combinations thereof and a second component of an herbicide selected from napropamide and napropamide-M.
  • one of the two components or both may be admixed with at least one or more agrochemically suitable excipients.
  • the kit-of-parts may comprise an additional herbicide as a third component or in a pre-mix with either of the two herbicidal components of the composition of the present invention.
  • the kit-of-parts may further comprise a component comprising an agrochemically suitable excipient.
  • the kit of parts may contain either of the L-glufosinate herbicide or a salt thereof and napropamide or napropamide-M previously admixed, individually or together, with an adjuvant or an agrochemically suitable excipient such that the two components may be tank mixed before applying.
  • the kit-of-parts may be further accompanied by a set of instructions in form of a manual, guide, booklet, pamphlet, and so forth.
  • the kit of parts comprises: (a) L-glufosinate, salts, esters, or combinations thereof; (b) at least one additional herbicide selected from napropamide, napropamide-M, or combinations thereof; and
  • the kit of parts comprises:
  • At least one agrochemically acceptable excipient at least one agrochemically acceptable excipient; and optionally further comprises:
  • the expected (or predicted) response of a combination of herbicides is calculated by taking the product of the observed response for each individual component of the combination when applied alone, divided by 100, and subtracting this value from the sum of the observed response for each component when applied alone.
  • An unexpected enhancement in efficacy of the combination is then determined by comparing the observed response of the combination to the expected (or predicted) response as calculated from the observed response of each individual component alone. If the observed response of the combination is greater than the expected (or predicted) response, or stated conversely, if the difference between the observed and expected response is greater than zero, then the combination is said to be synergistic or unexpectedly effective (Colby, S. R, Weeds, 1967(15), p. 20-22).
  • the Colby method requires only a single dose of each herbicide applied alone and the mixture of both doses.
  • the formula used to calculate the expected efficacy (EE) which was compared with the observed efficacy (OE) to determine the efficacy of the present disclosure is explained hereinbelow:
  • the invention includes embodiments in which particular subject matter is excluded, in full or in part, such as substances or materials, method steps and conditions, protocols, procedures, assays or analysis.
  • particular subject matter such as substances or materials, method steps and conditions, protocols, procedures, assays or analysis.
  • the invention includes embodiments in which particular subject matter is excluded, in full or in part, such as substances or materials, method steps and conditions, protocols, procedures, assays or analysis.
  • particular subject matter such as substances or materials, method steps and conditions, protocols, procedures, assays or analysis.
  • Trials were conducted to evaluate the efficacy of the combination comprising L-glufosinate and napropamide/napropamide-M on weeds Eleusine indica, Brachiaria decumbens, Euphorbia heterophylla, Borreria verticilata and Lolium species (ryegrass). Also, trials were carried out to evaluate the efficacy of the combination comprising L-glufosinate, napropamide/napropamide-M, and oxyfluorfen on weeds.
  • the soil used was sandy clay loam - sand: 68.0%; silt: 8.0%; clay: 24.0%.
  • Example 1 Efficacy of combination L-glufosinate and Napropamide on Eleusine indica
  • Table 1 demonstrates synergy on weeds using the combination comprising L- glufosinate and napropamide.
  • the percentage efficacy was calculated after 7, 14, 21 and 28 days of application (DAA).
  • the target weed was weedy Eleusine indica, and the concentration of the herbicide and the results are recorded in Table 1.
  • Table 2 demonstrates synergy on weeds using the combination comprising L- glufosinate and napropamide. The percentage efficacy was calculated after 7, 14 and 21 days of application (DAA). The target weed was weedy Brachiaria decumbens, and the concentration of the herbicide and the results are recorded in Table 2.
  • Example 3 Efficacy of combination L-glufosinate ammonium and Napropamide on Euphorbia heterophylla Experiment was conducted to assess the efficacy herbicidal combination comprising L-glufosinate ammonium (glufosinate-P-ammonium) and napropamide to control the weed, Euphorbia heterophylla.
  • Table 3 demonstrates synergy on the weed using the combination comprising L- glufosinate ammonium and Napropamide. The percentage efficacy was calculated after 7, 14, 21 and 28 days of applications (DAA). The target weed was Euphorbia heterophylla, and the concentration of the herbicide and the results are recorded in Table 3.
  • Table 4 demonstrates synergy on the weed using the combination comprising L- glufosinate ammonium, oxyfluorfen and napropamide.
  • the percentage efficacy was calculated after 7, 14, 21 and 28 days of applications (DAA).
  • the target weed was Euphorbia heterophylla, and the concentration of the herbicide and the results are recorded in Table 4. Therefore, synergy was observed in the control of weed Euphorbia heterophylla by application of herbicidal combination comprising L-glufosinate ammonium, napropamide and oxyfluorfen.
  • Example 5 Efficacy of combination L-glufosinate ammonium, Napropamide and Oxyfluorfen on Eleusine indica
  • Table 5 demonstrates synergy on the weed using the combination comprising L- glufosinate ammonium, oxyfluorfen and napropamide.
  • the percentage efficacy was calculated after 7, 21 and 28 days of applications (DAA).
  • the target weed was Eleusine indica, and the concentration of the herbicide and the results are recorded in Table 5.
  • Example 6 Efficacy of combination L-glufosinate ammonium, Napropamide and Oxyfluorfen on Borreria verticilata
  • Table 6 demonstrates synergy on the weed using the combination comprising L- glufosinate ammonium, oxyfluorfen and napropamide.
  • the percentage efficacy was calculated after 7 and 14 days of applications (DAA).
  • the target weed was Borreria verticilata, and the concentration of the herbicide and the results are recorded in Table 6.
  • Example 7 Efficacy of combination L-glufosinate ammonium, Napropamide and Oxyfluorfen on Lolium species
  • Table 7 demonstrates synergy on the weed using the combination comprising L- glufosinate ammonium, oxyfluorfen and Napropamide.
  • the percentage efficacy was calculated after 28 days of applications (DAA).
  • the target weed was Lolium species (ryegrass), and the concentration of the herbicide and the results are recorded in Table 7.

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Abstract

La présente invention concerne une combinaison herbicide comprenant du L-glufosinate, des sels, des esters ou des combinaisons de ceux-ci et au moins un herbicide supplémentaire choisi parmi le napropamide, le napropamide-M, ou des combinaisons de ceux-ci. Plus particulièrement, la présente invention concerne un procédé de lutte contre les mauvaises herbes avec des combinaisons herbicides synergiques comprenant du L-glufosinate, des sels, des esters, ou des combinaisons de ceux-ci et au moins un herbicide supplémentaire choisi parmi le napropamide, le napropamide-M, ou des combinaisons de ceux-ci.
PCT/GB2023/052295 2022-09-07 2023-09-06 Combinaison herbicide, composition et procédé de lutte contre les mauvaises herbes l'utilisant WO2024052665A1 (fr)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2777397A1 (fr) * 2013-03-15 2014-09-17 UPL Limited Lutte sélective contre les mauvaises herbes à l'aide de D-Napropamide
WO2019030104A1 (fr) * 2017-08-09 2019-02-14 Basf Se Mélanges herbicides comprenant du l-glufosinate ou son sel et au moins un inhibiteur de vlcfa
WO2019030086A2 (fr) * 2017-08-09 2019-02-14 Basf Se Mélanges herbicides comprenant du l-glufosinate et leur utilisation dans les cultures de colza
WO2021151744A1 (fr) * 2020-01-31 2021-08-05 Basf Se Combinaisons herbicides comprenant du glufosinate et de l'oxyfluorène

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2777397A1 (fr) * 2013-03-15 2014-09-17 UPL Limited Lutte sélective contre les mauvaises herbes à l'aide de D-Napropamide
WO2019030104A1 (fr) * 2017-08-09 2019-02-14 Basf Se Mélanges herbicides comprenant du l-glufosinate ou son sel et au moins un inhibiteur de vlcfa
WO2019030086A2 (fr) * 2017-08-09 2019-02-14 Basf Se Mélanges herbicides comprenant du l-glufosinate et leur utilisation dans les cultures de colza
WO2021151744A1 (fr) * 2020-01-31 2021-08-05 Basf Se Combinaisons herbicides comprenant du glufosinate et de l'oxyfluorène

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "BASF acquires proprietary technology for L-glufosinate ammonium from AgriMetis(TM)", 14 September 2020 (2020-09-14), XP093098739, Retrieved from the Internet <URL:https://www.basf.com/global/en/media/news-releases/2020/09/p-20-297.html> [retrieved on 20231107] *
CAS , no. 70033-13-5
COLBY, S. R, WEEDS, no. 15, 1967, pages 20 - 22
SHROFF ET AL: "Weed control using D-napropramide composition", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, 1 January 2013 (2013-01-01), XP002780609 *

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