WO2023249158A1 - Composition de polyéthylène et son procédé de sa préparation - Google Patents

Composition de polyéthylène et son procédé de sa préparation Download PDF

Info

Publication number
WO2023249158A1
WO2023249158A1 PCT/KR2022/010367 KR2022010367W WO2023249158A1 WO 2023249158 A1 WO2023249158 A1 WO 2023249158A1 KR 2022010367 W KR2022010367 W KR 2022010367W WO 2023249158 A1 WO2023249158 A1 WO 2023249158A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
microstructure
cosmetic composition
oil
extract
Prior art date
Application number
PCT/KR2022/010367
Other languages
English (en)
Korean (ko)
Inventor
장철
Original Assignee
(주) 디에스테크
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주) 디에스테크 filed Critical (주) 디에스테크
Publication of WO2023249158A1 publication Critical patent/WO2023249158A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to cosmetic compositions and methods for producing the same. More specifically, it relates to a cosmetic composition containing microstructures and a method for producing the same.
  • the active agent can be easily absorbed without hindering absorption by the epidermis layer of the skin.
  • the microstructure contains a biodegradable material, as the microneedles included in the microstructure gradually decompose, the active agent is slowly leaked out, so that it can be continuously absorbed. Accordingly, side effects caused by injecting an excessive amount of the active agent at once can be effectively prevented.
  • Micro structures can be applied, for example, with rollers, patches, stamps, etc.
  • rollers, patches, stamps, etc. there is a problem that skin irritation or pain occurs during the process of directly penetrating and absorbing the microstructure into the skin.
  • the purpose of the present invention is to provide a cosmetic composition containing microstructures.
  • the purpose of the present invention is to provide a method for producing a cosmetic composition containing microstructures.
  • the cosmetic composition according to an exemplary embodiment includes 0.1 to 30% by weight of microstructure, 50 to 90% by weight of hydrocarbon-based oil, 5 to 25% by weight of silicone powder, 0.001 to 0.1% by weight of vegetable oil, and 0.1 to 1% by weight of fragrance, based on the total weight of the composition. It may include weight percent.
  • the cosmetic composition according to an exemplary embodiment includes 0.1 to 30% by weight of microstructure, 70 to 90% by weight of purified water, 5 to 20% by weight of polyhydric alcohol, 0.1 to 1% by weight of high molecular weight polymer, and 0.001 to 1% by weight of functional peptide, based on the total weight of the composition.
  • % vegetable oil 0.1 to 2% by weight, polysaccharide 0.01 to 0.5% by weight, phenoxyethanol 0.05 to 1% by weight, hyaluronic acid 0.1 to 1% by weight, niacinamide 1 to 10% by weight, white-throated mushroom sporangia extract 0.01 to 10%.
  • berry extract 0.1 to 1% by weight adenosine 0.01 to 0.1% by weight, and fragrance 0.005 to 0.1% by weight. % may be included.
  • the microstructure may include a microneedle structure that dissolves within the skin.
  • the microstructure may have an average length of 10 to 1,000 ⁇ m and an average diameter of 10 to 1,000 ⁇ m.
  • the microstructure contains 40 to 70% by weight of sodium hyaluronate, 10 to 30% by weight of lactose, 10 to 30% by weight of glycerin, 0.1 to 5% by weight of madecassoside, and acetyl hexamethylene based on the total weight of the structure.
  • Peptide 0.001 to 0.1% by weight, licorice root extract 0.001 to 0.1% by weight, port marigold flower extract 0.0001 to 0.1% by weight, caprylyl glycol 0.01 to 0.1% by weight, propanediol 1 to 10% by weight, ethylhexylglycerin It may contain 0.1 to 1% by weight and 0.001 to 0.1% by weight of 1,2-hexanediol.
  • the hydrocarbon-based oil is caprylic/capric triglyceride, triethylhexanoin, octyldodecanol, hydrogenated polyisobutene, cetyl ethyl hexanoate, butylene glycol dica.
  • Prilate/Dicaprate Isopropyl Myristate, Polyglyceryl-2 Triisostearate, Glyceryl Ethylhexanoate/Stearate/Adipate, Ethylhexyl Palmitate, Isostearyl Isostearate, Diisopropyl It may include at least one selected from the group consisting of dimer dilinoleate, propylene glycol dibenzoate, isopropyl palmitate, and isohexadecane.
  • the silicone powder is silica, silica dimethyl silylate, polymethylsilsesquioxane, vinyl dimethicone/methicone silsesquioxane crosspolymer, elastomer, dimethicone/dimethicone crosspolymer, dimethicone At least one selected from the group consisting of phenyldimethicone/vinyldiphenyldimethicone/silsesquioxane crosspolymer, dimethicone/vinyldimethicone crosspolymer, polysilicon-1 crosspolymer, polysilicon-11, and polysilicon-22. may include.
  • the polyhydric alcohol is dipropylene glycol, glycerin, propylene glycol, butylene glycol, pentylene glycol, 1,2-hexanediol, caprylyl glycol, and ethylhexylglycerin. , and may include at least one selected from the group consisting of sorbitol.
  • the high molecular weight polymer may include at least one selected from the group consisting of sodium polyacrylate, polyglutamic acid, PVM/MA copolymer, and ammonium acrylodimethyl taurate/VP copolymer. there is.
  • the functional peptide is at least selected from the group consisting of hexapeptide-9, hexapeptide-11, acetyl hexapeptide-8, acetyl octapeptide-3, palmitoyl pentapeptide-4, and copper tripeptide-1. It can contain one.
  • the polysaccharide may include at least one selected from the group consisting of carrageenan, agarose, cellulose gum, xanthan gum, arabica gum, and guar gum.
  • the vegetable oil is at least one selected from the group consisting of jojoba seed oil, meadowfoam seed oil, sunflower seed oil, olive oil, argan kernel oil, avocado oil, macadamia seed oil, evening primrose oil, squalane, and castor oil. It can contain one.
  • a method of manufacturing a cosmetic composition includes preparing a microstructure; Preparing a microstructure mixture by mixing the microstructure, silicon powder, and fragrance; Emulsifying the microstructure mixture by mixing it with oil; And it may include cooling and defoaming.
  • a method of manufacturing a cosmetic composition according to an exemplary embodiment includes preparing a microstructure; Preparing an aqueous base solvent; And it may include mixing the base solvent and the aqueous base solvent to prepare a mixed microstructure solution.
  • preparing the microstructure includes forming a preliminary microstructure by putting a composition for forming a microstructure into a mold and compressing it; Drying the preliminary microstructure; Separating the dried preliminary microstructure from the mold; And it may include the step of crushing the dried and separated preliminary microstructure to form a microstructure.
  • the composition for forming microstructures includes 40 to 70% by weight of sodium hyaluronate, 10 to 30% by weight of lactose, 10 to 30% by weight of glycerin, 0.1 to 5% by weight of madecassoside, and acetylhexapeptide.
  • 0.001 to 0.1% by weight licorice root extract 0.001 to 0.1% by weight, port marigold flower extract 0.0001 to 0.1% by weight, caprylyl glycol 0.01 to 0.1% by weight, propanediol 1 to 10% by weight, ethylhexylglycerin 0.1 to 1% by weight and may include 0.001 to 0.1% by weight of 1,2-hexanediol.
  • the micro structure mixture may have a mixing ratio of silicon powder to the micro structures of 1 to 5, and a mixing ratio of the fragrance to the micro structures may be 1/10 to 1/20.
  • the mixing ratio of the oil to the microstructure mixture may be 3 to 5.
  • the aqueous base solvent is 70 to 90% by weight of purified water, 5 to 20% by weight of polyhydric alcohol, 0.1 to 1% by weight of high molecular weight polymer, 0.05 to 1% by weight of phenoxyethanol, and 0.1 to 1% by weight of hyaluronic acid.
  • % functional peptide 0.001 to 1% by weight, niacinamide 1 to 10% by weight, white wood ear mushroom sporangia fruit extract 0.01 to 1% by weight, berry extract 0.1 to 1% by weight, licorice extract 0.001 to 0.1% by weight, port marigold flower It may include 0.0005 to 0.5% by weight of extract, 0.1 to 2% by weight of vegetable oil, 0.1 to 2% by weight of panthenol, 0.01 to 0.1% by weight of adenosine, 0.01 to 0.5% by weight of polysaccharide, and 0.005 to 0.1% by weight of fragrance.
  • the weight ratio of the microstructure to the weight of the aqueous base solvent may be 0.1 to 1.
  • the cosmetic composition containing the microstructure of the present invention can be applied to the skin to quickly inject the active agent into the skin without pain or irritation.
  • the method for producing a cosmetic composition containing the microstructure of the present invention can simplify the process and can be easily mass-produced.
  • Figure 1 is an example of a method for manufacturing a microstructure.
  • Figures 2 and 3 each show examples of a method for manufacturing a cosmetic composition containing microstructures.
  • the present invention provides a cosmetic composition containing microstructures and a method for producing the same.
  • the microstructure according to one embodiment contains 40 to 70% by weight of sodium hyaluronate, 10 to 30% by weight of lactose, 10 to 30% by weight of glycerin, 0.1 to 5% by weight of madecassoside, and 0.001% by weight of acetyl hexapeptide, based on the total weight of the structure. to 0.1% by weight, licorice root extract 0.001 to 0.1% by weight, port marigold flower extract 0.0001 to 0.1% by weight, caprylyl glycol 0.01 to 0.1% by weight, propanediol 1 to 10% by weight, ethylhexylglycerin 0.1 to 0.1%. It may contain 1% by weight and 0.001 to 0.1% by weight of 1,2-hexanediol. If necessary, additional water may be added.
  • Sodium hyaluronate also called hyaluronic acid, has skin moisturizing and skin conditioning effects when used in cosmetic compositions.
  • sodium hyaluronate may be included in an amount of 40 to 70% by weight, 45 to 65% by weight, or 50 to 60% by weight based on the total weight of the microstructure.
  • the molecular weight of sodium hyaluronate is not limited to this, but is preferably 1,000 to 5,000,000 (kDa) in order to realize various physical properties and biocompatibility.
  • Lactose may be included as a sugar component to increase mechanical strength with sodium hyaluronate. Lactose may be included in an amount of 10 to 30% by weight, 10 to 25% by weight, and 12 to 20% by weight based on the total weight of the microstructure. However, it is not limited thereto, but for example, Dextrin, Malto-dextrin, Xylose, Sucrose, Maltose, Glucose, Glucosamine ( Glucosamine, Glucuronic acid, Rhamnose, Mannose, Fucose, Arabinose, Acetylglucosamine, Inositol, Trehalose, Isomalt, Xylitol, and Erythritol may be used. Additionally, sugar components can be used as excipients.
  • Glycerin is a type of polyhydric alcohol and can be added to control dispersion and viscosity.
  • Ethylhexylglycerin is a glyceryl ether, an organic compound, and a type of glycerin. It provides antibacterial and deodorizing effects, and can also act as a humectant or solvent. It may contain 10 to 30% by weight, 10 to 25% by weight, and 12 to 20% by weight based on the total weight of the microstructure.
  • Ethylhexylglycerin may be included in an amount of 0.1 to 1% by weight, for example, 0.1 to 0.5% by weight.
  • Madecassoside is an ingredient extracted from Centella asiatica extract and is effective in improving inflammation and has a skin regenerative effect. In addition, it is effective in controlling oil and water balance by controlling excessive sebum secretion. It is also effective in improving itchiness caused by dry skin. Madecassoside may be included in an amount of 0.1 to 5% by weight, 0.1 to 3% by weight, for example, 0.1 to 1% by weight, based on the total weight of the microstructure.
  • Acetyl hexapeptide is an active ingredient for improving wrinkles.
  • acetylhexapeptide-8 can be used. It may be included in an amount of 0.001 to 0.1% by weight or 0.001 to 0.05% by weight based on the total weight of the structure.
  • Licorice root extract contains glycyrrhizin, a triterpene saponin, as an active ingredient and has antibacterial, anti-allergic, and antioxidant physiological activities. It may be included in an amount of 0.001 to 0.1% by weight or 0.001 to 0.05% by weight based on the total weight of the structure.
  • the flavonoids in port marigold flower extract the main component of calendula, have strong antioxidant and soothing effects. Therefore, it suppresses inflammation and has excellent skin regeneration effects. It may be included in an amount of 0.0001 to 0.1% by weight or 0.0001 to 0.01% by weight based on the total weight of the structure.
  • Caprylyl Glycol is an ingredient mainly extracted from coconut oil and can be used as a skin moisturizer and skin softener. Additionally, it has an antibacterial effect and can be used as a natural preservative. It may be included in an amount of 0.01 to 0.1% by weight, 0.01 to 0.08% by weight, and 0.001 to 0.05% by weight based on the total weight of the structure.
  • Propanediol is a natural ingredient extracted by fermentation from corn and can be used as a moisturizer, solvent, viscosity regulator, and preservative. It is also effective in preventing skin aging due to its tocopherol content. Based on the total weight of the structure, propanediol may be included in an amount of 1 to 10% by weight and 2 to 9% by weight.
  • 1,2-hexanediol provides excellent moisturizing and nutritional properties and has excellent stability even under wide pH conditions and high temperature processes. It may be included in an amount of 0.001 to 0.1% by weight or 0.002 to 0.05% by weight based on the total weight of the structure.
  • Figure 1 schematically shows a method of manufacturing a microstructure according to an embodiment.
  • a composition for forming microstructures can be prepared (for example, S-111).
  • a composition for forming microstructures may be prepared with the above-mentioned ingredients and contents. If necessary, extra water may be included.
  • composition for forming the micro structure may be placed in a mold and compressed to form a preliminary micro structure (for example, S-112).
  • compression may be performed by applying 1.5 to 5 tons of pressure for 5 to 300 seconds.
  • the prepared preliminary microstructure can be dried and separated from the mold (e.g., S-113). For example, drying can be done with hot air at 20°C to 70°C for 15 to 90 minutes. During the drying process, solvents, water, etc. contained in the preliminary microstructure may evaporate.
  • drying may be freeze-drying.
  • the prepared preliminary microstructure can be frozen at a temperature of -10°C to -30°C and left under reduced pressure to remove moisture in the sample by sublimation.
  • drying may be hot air drying and freeze drying.
  • moisture may be additionally removed by freezing at a temperature of -10°C to -30°C and leaving under reduced pressure.
  • the dried preliminary microstructure can be crushed or pulverized into an appropriate size or shape to form a microstructure (for example, S-114).
  • the formed microstructure can be used as a raw material for cosmetic compositions.
  • crushing or pulverizing can be done by mechanical milling of microstructures, such as roll-mill, ball-mill, hammer-mill, high energy ball mill, or planetary mill.
  • a planetary mill, stirred ball mill, vibrating mill, or jet-mill can be used.
  • the cosmetic composition according to an exemplary embodiment may be, for example, an oil gel-type cosmetic composition.
  • the oil gel type composition contains 0.1 to 30% by weight of microstructure, 50 to 90% by weight of hydrocarbon oil, 0.001 to 0.1% by weight of vegetable oil, 5 to 25% by weight of silicone powder, and 0.1 to 1% by weight of fragrance based on the total weight of the composition. It can be included.
  • the microstructure may be included in an amount of 0.1 to 30% by weight. Preferably it may be contained in 1 to 25% by weight, more preferably in 5 to 20% by weight.
  • the microstructure When applied to the skin in the above range, the microstructure can be absorbed without skin pain or irritation, and the absorption rate can also be improved. Additionally, the shape of the microstructure can also provide a skin peeling effect.
  • the microstructure may include soluble microneedle structures that dissolve within the skin.
  • dissolvable microneedles can be composed of a support portion and a drug portion. The drug portion dissolves within the skin and may dissolve or disintegrate when the microneedle is applied to the skin.
  • dissolvable microneedles may be cone-shaped, jar-shaped, or horn-shaped polyhedrons with a base of a polygonal structure consisting of three or more sides.
  • soluble microneedles may have an average length of 10 to 1,000 ⁇ m.
  • the average diameter of soluble microneedles may be 10 to 1,000 ⁇ m.
  • the diameter can fulfill all the functions of cosmetics.
  • hydrocarbon-based oil may be included in an amount of 50 to 90% by weight. Preferably it may contain 55 to 85% by weight, more preferably 60 to 85% by weight. Within the above range, it can have an excellent skin moisturizing effect and act as a softener, and can also act as a solvent.
  • the hydrocarbon-based oil includes caprylic/capric triglyceride, triethylhexanoin, octyldodecanol, hydrogenated polyisobutene, cetyl ethyl hexanoate, butylene glycol dicaprylate.
  • Isopropyl Myristate Polyglyceryl-2 Triisostearate, Glyceryl Ethylhexanoate/Stearate/Adipate, Ethylhexyl Palmitate, Isostearyl Isostearate, Diisopropyl Dimerda It may be irisoleate, propylene glycol dibenzoate, isopropyl palmitate, isohexadecane, or mixtures thereof.
  • vegetable oil may be included in an amount of 0.001 to 0.1% by weight. Preferably, it may contain 0.001 to 0.08% by weight, more preferably 0.003 to 0.06% by weight. Within the above range, various unsaturated fat-soluble active ingredients necessary for skin improvement can be provided.
  • the vegetable oil may be jojoba seed oil, meadowfoam seed oil, sunflower seed oil, olive oil, argan kernel oil, avocado oil, macadamia seed oil, evening primrose oil, squalane, castor oil, or mixtures thereof.
  • silicone powder may contain 5 to 25% by weight of silicone powder based on the total weight of the composition. Preferably it may be contained in 5 to 20% by weight, more preferably in 10 to 15% by weight. Within the above range, excellent water absorption and oil absorption can be provided.
  • the silicone powder may include silica, silica dimethyl silylate, polymethyl silsesquioxane, vinyl dimethicone/methicone silsesquioxane crosspolymer, elastomer, dimethicone/dimethicone crosspolymer, and diphenyl dimethicone. It may be chicone/vinyl diphenyl dimethicone/silsesquioxane crosspolymer, dimethicone/vinyl dimethicone crosspolymer, polysilicon-1 crosspolymer, polysilicon-11, polysilicon-22, or a mixture thereof.
  • fragrance may contain 0.1 to 1% by weight of fragrance, preferably 0.1 to 0.8% by weight, based on the total weight of the composition.
  • fragrance there is no particular limitation as long as the fragrance within the above range is commonly used in cosmetic compositions.
  • the cosmetic composition according to an exemplary embodiment may be, for example, an aqueous type cosmetic composition.
  • the aqueous type composition contains 0.1 to 30% by weight of microstructure, 70 to 90% by weight of purified water, 5 to 20% by weight of polyhydric alcohol, 0.1 to 1% by weight of high molecular weight polymer, and 0.001 to 1% by weight of functional peptide based on the total weight of the composition.
  • % vegetable oil 0.1 to 2% by weight, polysaccharide 0.01 to 0.5% by weight, phenoxyethanol 0.05 to 1% by weight, hyaluronic acid 0.1 to 1% by weight, niacinamide 1 to 10% by weight, white-throated mushroom sporangia extract 0.01 to 10%.
  • berry extract 0.1 to 1% by weight adenosine 0.01 to 0.1% by weight, and fragrance 0.005 to 0.1% by weight. % may be included.
  • purified water may be included in an amount of 70 to 90% by weight, preferably 80 to 90% by weight.
  • Purified water may be, for example, general purified water or ultrapure purified water.
  • General purified water is water commonly used in pharmaceuticals, cosmetics, etc., and has a dissolved solids content of 1.0 to 0.5 ppm, indicating purity, a filter size of 0.2 to 0.45 ⁇ m used to remove particulates and microorganisms when producing purified water, and a pH of 0.2 to 0.45 ⁇ m. It may be a weak acid or a weak alkali.
  • Ultrapure purified water has a very high purity with a dissolved solid content of 0.03ppm, and the size of the filter used to produce ultrapure purified water is 0.001 ⁇ m, which removes 99.99% of microorganisms.
  • ultrapure purified water not only prevents the auto-oxidation reaction of the composition by removing metal ions, but also prevents polymer agglomeration caused by metal ions, allowing the formulation to be applied evenly while being mild.
  • the polyhydric alcohol may be included in an amount of 5 to 20% by weight, preferably 10 to 20% by weight.
  • Polyhydric alcohol is a solvent containing two or more hydroxy groups, for example, dipropylene glycol, glycerin, propylene glycol, butylene glycol, pentylene glycol, 1,2-hexanediol, capryl. It may be lyl glycol, ethylhexylglycerin, or sorbitol or a mixture thereof.
  • the polymer may be included in an amount of 0.1 to 1% by weight, preferably 0.2 to 0.8% by weight. This can increase the viscosity of the composition and help stabilize the formulation.
  • the high molecular weight polymer may be, for example, sodium polyacrylate, polyglutamic acid, PVM/MA copolymer, ammonium acrylodimethyltaurate/VP copolymer.
  • the functional peptide may be 0.001 to 1% by weight, preferably 0.001 to 0.01% by weight. As a result, it can provide antioxidant and skin anti-aging effects.
  • the functional peptide may be, for example, hexapeptide-9, hexapeptide-11, acetyl hexapeptide-8, acetyl octapeptide-3, palmitoyl pentapeptide-4 or copper tripeptide-1.
  • polysaccharides may be included in an amount of 0.01 to 0.5% by weight, preferably 0.01 to 0.1% by weight. Accordingly, it is possible to provide a cosmetic composition with excellent spreadability and excellent absorption.
  • Polysaccharides may be, for example, carrageenan, agar and agarose, cellulose gum, xanthan gum, gum arabica, guar gum.
  • phenoxyethanol may be included in an amount of 0.05 to 1% by weight, preferably 0.1 to 0.5% by weight
  • hyaluronic acid may be included in an amount of 0.1 to 1% by weight, preferably 0.1 to 0.5% by weight.
  • niacinamide may be included in an amount of 1 to 10% by weight, preferably 1 to 5% by weight
  • panthenol may be included in an amount of 0.1 to 2% by weight, preferably 0.1 to 1% by weight
  • adenosine may be included in an amount of 0.01 to 1% by weight. It may be included at 0.1% by weight, preferably at 0.01 to 0.05% by weight.
  • the extract based on the total weight of the composition, it may include 0.01 to 1% by weight of White-eared mushroom sporangia fruit extract, 0.1 to 1% by weight of berry extract, 0.001 to 0.1% by weight of licorice extract, and 0.0005 to 0.5% by weight of port marigold flower extract. and is not limited thereto.
  • Cosmetic compositions according to some embodiments may further include other active ingredients known in the art for use in cosmetics in addition to the ingredients listed above.
  • kazinol, arbutin, ethyl ascorbyl ether, ascorbyl glucoside, Magnesium Ascorbyl Phosphate, ascorbyl tetraisopalmitate It may be ascorbyl tetraisopalmitate, alpha-bisabolol, retinol, retinyl palmitate, polyethoxylated retinamide and derivatives thereof, but in addition to this, sugar
  • active ingredients can be used in the field to improve efficacy such as improving skin condition, improving wrinkles, improving inflammation, moisturizing, whitening, blocking ultraviolet rays, and improving skin barrier function.
  • the other active ingredients may be included, for example, at 0.1 to 10% by weight, 0.1 to 8% by weight, 0.1 to 5% by weight, 0.1 to 3% by weight, and 0.1 to 1% by weight based on the total weight of the composition, but are limited thereto. no.
  • Figure 2 schematically shows an example of a method for manufacturing a cosmetic composition containing microstructures.
  • a microstructure e.g., S-100
  • the raw materials included in each step may be, for example, raw materials for an oil gel-type cosmetic composition. Specific details of the microstructure, silicone powder, fragrance, and oil are the same as described above.
  • the microstructure may be mixed with silicon powder and fragrance to form a microstructure mixture (for example, S-200). Mixing can be performed for example.
  • the mixing ratio of silicon powder to microstructure may be 1 to 5, preferably 1 to 3.
  • the mixing ratio of the fragrance to the micro structure may be 1/10 to 1/20, and preferably 1/10 to 1/15.
  • the microstructure mixture can be emulsified by mixing it with oil (e.g., S-300).
  • oil e.g., S-300
  • the mixing ratio of oil to the microstructure mixture may be 3 to 5.
  • the oil may include vegetable oil and hydrocarbon-based oil, and the hydrocarbon-based oil may preferably be caprylic/capric triglyceride, triethylhexanoin, octyldodecanol, or mixtures thereof.
  • the vegetable oil may preferably be jojoba seed oil, meadowfoam seed oil, sunflower seed oil, olive oil, argan kernel oil, or a mixture thereof.
  • the mixture can be mixed by raising the temperature to 60 to 80°C and passing it through a high-pressure homogenizer.
  • a cosmetic composition containing microstructures can be obtained through a cooling and defoaming process (for example, S-400). Cooling is carried out at 30 to 45°C and then defoamed to finally obtain a cosmetic composition.
  • a cooling and defoaming process for example, S-400. Cooling is carried out at 30 to 45°C and then defoamed to finally obtain a cosmetic composition.
  • Figure 3 schematically shows another example of a method for manufacturing a cosmetic composition containing microstructures.
  • the raw materials included in each step may be, for example, raw materials for an aqueous type cosmetic composition.
  • microstructure e.g., S-110.
  • S-110 a microstructure
  • the specific details of the micro structure are the same as described above.
  • an aqueous base solvent (e.g., S-120).
  • the aqueous base solvent is 70 to 90% by weight of purified water, 5 to 20% by weight of polyhydric alcohol, 0.1 to 1% by weight of high molecular weight polymer, 0.05 to 1% by weight of phenoxyethanol, 0.1 to 1% by weight of hyaluronic acid, and 0.001 to 1% by weight of functional peptide.
  • niacinamide 1 to 10% by weight white-throated mushroom sporangia extract 0.01 to 1% by weight, berry extract 0.1 to 1% by weight, licorice extract 0.001 to 0.1% by weight, port marigold flower extract 0.0005 to 0.5% by weight, vegetable It may include 0.1 to 2% by weight of oil, 0.1 to 2% by weight of panthenol, 0.01 to 0.1% by weight of adenosine, 0.01 to 0.1% by weight of polysaccharide, and 0.005 to 0.1% by weight of fragrance.
  • the base solvent and the water-based base solvent can be mixed to prepare a microstructure mixed solution (for example, S-130).
  • a microstructure mixed solution for example, S-130.
  • Mixing can be carried out at room temperature.
  • the weight ratio of the microstructure to the weight of the aqueous base solvent may be 0.1 to 1, preferably 0.1 to 0.5, and more preferably 0.1 to 0.3.
  • Micro structures according to some embodiments do not require additional processes for application to patches, rollers, stamps, etc., and can be manufactured by simply adding the micro structures to a cosmetic composition. Therefore, the process can be simplified and mass production is easy.
  • the formulation of the cosmetic composition may be in the form of a general emulsified formulation or solubilized formulation.
  • lotion such as flexible lotion or nourishing lotion, emulsion such as facial lotion and oil, cream such as nutritional cream, moisture cream, eye cream, essence, cosmetic ointment, spray, oil gel, pack, sunscreen, makeup base, liquid
  • cream such as nutritional cream, moisture cream, eye cream, essence, cosmetic ointment, spray, oil gel, pack, sunscreen, makeup base, liquid
  • It can have formulations such as foundation type, solid type or spray type, makeup remover such as powder, cleansing cream, cleansing lotion, cleansing oil, cleansing foam, soap, body wash, etc.
  • the content of active ingredients in cosmetic compositions may vary depending on formulation and purpose. For example, a relatively high concentration is desirable for wash-off type cosmetics such as makeup removers and detergents, in which the active ingredients stay on the skin for a short period of time.
  • wash-off type cosmetics such as makeup removers and detergents
  • leave-on type cosmetics such as lotion, emulsion, oil gel, cream, and essence, whose active ingredients stay on the skin for a long period of time, preferably have a relatively low concentration compared to wash-off type cosmetics.
  • a microstructure composition was prepared by mixing and stirring the ingredients in Table 1 below according to their contents.
  • the composition was poured into a mold and pressed with 1.5 to 5 tons for 5 to 300 seconds.
  • the compressed preliminary microstructure was dried with hot air at 20°C to 70°C for 15 to 90 minutes. At this time, the solvent is removed during drying.
  • the dried preliminary microstructure was separated from the mold and pulverized with a hammer mill to obtain microstructures satisfying an average length of 100 to 500 ⁇ m and an average diameter of 100 to 500 ⁇ m.
  • caprylic glycol 0.0465 Acetylhexapeptide-8 0.00465 Sodium Hyaluronate 57.10779 lactose 16.27665 glycerin 16.27665 Port marigold flower extract 0.00093 1,2-hexanediol 0.0372 Licorice root extract 0.0186 Propanediol 7.44075 caprylyl glycol 1.39514 Ethylhexylglycerin 0.46505 Madecassoside 0.93009
  • Preparation Example 1 The microstructure of Preparation Example 1 was mixed with the ingredients shown in Table 2 below according to their contents, heated to 60 to 80°C, and then passed through a high-pressure homogenizer to sufficiently mix. Cooling was performed at 30 to 45°C and then defoamed to prepare an oil gel-type cosmetic composition.
  • Preparation Example 1 The microstructure of Preparation Example 1 was mixed with an aqueous base solvent containing the ingredients shown in Table 3 below.
  • a water-based cosmetic composition was prepared at a mixing ratio of 30 parts by weight based on 100 parts by weight of the water-based base.
  • composition content Purified water 48.9200 Purified water 100.0000 1.0% Sodium Hyaluronate Solution 25.0000 Purified water 98.2500 Sodium Hyaluronate 1.0000 Phenoxyethanol 0.17500 Ethylhexylglycerin 0.0500 glycerin 5.0000 glycerin 100.0000 Zilgel Oil 4.0000 Purified water 55.0000 glycerin 43.0000 Sodium polyacrylate 1.0000 PVM/MA copolymer 1.0000 Niacinamide 2.0000 Niacinamide 100.0000 MS ⁇ -PGA 0.5% 2.0000 Purified water 62.5000 Butylene glycol 35.0000 1,2-hexanediol 2.0000 polyglutamic acid 0.5000 Phyto HA 2.0000 Purified water 88.0000 Butylene glycol 10.0000 Phenoxyethanol 1.0000 White-throated mushroom sporangia extract 1.0000 Butylene glycol 2.0000 Butylene glycol 100.0000 1,2-hexanediol 1.5000 1,2-hex
  • a microneedle patch was manufactured by attaching the microstructure of Preparation Example 1 to an adhesive sheet.
  • the degree of skin irritation of the cosmetic compositions according to Examples and Comparative Examples was confirmed.
  • the degree of skin irritation over time was observed in 50 healthy men and women using the example on one cheek and the comparative example on the other cheek.
  • the judgment criteria and results are shown in Table 4.
  • the Examples can provide similar absorption speed and shine as the Comparative Example.
  • Excellent absorption rate and absorption speed which are advantages of using existing needle-type microstructures, can be provided at a similar level.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Physics & Mathematics (AREA)
  • Geometry (AREA)

Abstract

La présente invention concerne une composition cosmétique et un procédé de préparation de celle-ci. Le produit cosmétique microstructuré peut injecter plus efficacement un agent actif dans la peau sans douleur ni irritation de la peau.
PCT/KR2022/010367 2022-06-24 2022-07-15 Composition de polyéthylène et son procédé de sa préparation WO2023249158A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2022-0077651 2022-06-24
KR1020220077651A KR102585994B1 (ko) 2022-06-24 2022-06-24 화장료 조성물 및 이의 제조 방법

Publications (1)

Publication Number Publication Date
WO2023249158A1 true WO2023249158A1 (fr) 2023-12-28

Family

ID=88296003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2022/010367 WO2023249158A1 (fr) 2022-06-24 2022-07-15 Composition de polyéthylène et son procédé de sa préparation

Country Status (2)

Country Link
KR (1) KR102585994B1 (fr)
WO (1) WO2023249158A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102640649B1 (ko) * 2023-11-28 2024-02-28 주식회사 쌤시크코스메틱 판테놀이 함유된 기능성 화장료 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100834484B1 (ko) * 2006-12-28 2008-06-09 주식회사 엘지생활건강 식물 혼합 추출물인 셀리언스를 함유하는 오일형 화장료조성물
KR101873337B1 (ko) * 2017-01-02 2018-07-02 오한선 미세 타공이 형성된 하이드로겔 패치의 제조방법 및 이에 의해 제조된 하이드로겔 패치
KR20220038822A (ko) * 2016-03-01 2022-03-29 조지아 테크 리서치 코오포레이션 마이크로니들 입자, 조성물, 및 치료방법 및 관심 물질 전달방법
KR20220085373A (ko) * 2020-12-15 2022-06-22 (주) 디에스테크 마이크로 구조체 및 이의 제조 방법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102409490B1 (ko) 2020-07-03 2022-06-16 한남대학교 산학협력단 국소피부용 마이크로니들 및 이의 제조방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100834484B1 (ko) * 2006-12-28 2008-06-09 주식회사 엘지생활건강 식물 혼합 추출물인 셀리언스를 함유하는 오일형 화장료조성물
KR20220038822A (ko) * 2016-03-01 2022-03-29 조지아 테크 리서치 코오포레이션 마이크로니들 입자, 조성물, 및 치료방법 및 관심 물질 전달방법
KR101873337B1 (ko) * 2017-01-02 2018-07-02 오한선 미세 타공이 형성된 하이드로겔 패치의 제조방법 및 이에 의해 제조된 하이드로겔 패치
KR20220085373A (ko) * 2020-12-15 2022-06-22 (주) 디에스테크 마이크로 구조체 및 이의 제조 방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Recommendation PW Solution Celeb Ampoule-It's Mild and Moisturizing Without Irritation", 19 September 2018 (2018-09-19), Retrieved from the Internet <URL:https://blog.naver.com/grb5735/221362173663> *

Also Published As

Publication number Publication date
KR102585994B1 (ko) 2023-10-06

Similar Documents

Publication Publication Date Title
CN108904302B (zh) 水溶性富勒烯外用组合物
WO2017052267A1 (fr) Composition comprenant des vésicules extracellulaires dérivées d&#39;extrait de plante destinée à l&#39;état de la peau et à prévenir la perte de cheveux
JP3926711B2 (ja) 表皮の偏平化を予防、防止、改善する皮膚老化防止用組成物
JP2005220084A (ja) アセロラ種子抽出物含有組成物
KR101763373B1 (ko) 식물 추출물을 유효성분으로 함유하는 화장료 조성물
WO2018164309A1 (fr) Composition cosmétique comprenant un extrait d&#39;onagre
US20090061030A1 (en) Cosmetic material containing swee pea extract
KR102310170B1 (ko) 피부 상태 개선용 화장료 조성물 및 이의 제조방법
WO2023249158A1 (fr) Composition de polyéthylène et son procédé de sa préparation
JP2003201229A (ja) マトリックスメタロプロテアーゼ活性阻害剤および抗老化用化粧料
JP2006028148A (ja) 外用組成物
JP3791775B2 (ja) 皮膚外用剤
EP3777825A1 (fr) Composition de formulation lyophilisée, kit cosmétique pour usage externe sur la peau la comprenant et son utilisation
KR101419588B1 (ko) 홍삼 오일을 유효성분으로 함유하는 피부 보습용 조성물
KR102283326B1 (ko) 락토바실러스발효물, 락토코쿠스발효물, 효모폴리펩타이드, 락토바실러스 아시도필루스 포도발효물을 유효성분으로 하는 화장료 조성물
KR102022230B1 (ko) 피부 흡수 증진을 위한 에멀젼 구조 및 이의 제조방법
JP2007045733A (ja) ヒアルロニダーゼ阻害剤
KR101953676B1 (ko) 악마의 발톱 초음파 추출물을 함유하는 피부 보습용 화장료 조성물
JP3660833B2 (ja) 血行促進剤
KR102247589B1 (ko) 모루셀라 추출물 및 께묵 추출물을 유효 성분으로 포함하는 피부 개선용 화장료 조성물
WO2024135943A1 (fr) Procédé de fabrication d&#39;une microstructure et microstructure ainsi fabriquée
WO2018194359A1 (fr) Composition améliorant la peau
WO2016171482A1 (fr) Composition cosmétique comprenant un extrait d&#39;apitoxine, et son procédé de fabrication
JP4716497B2 (ja) 皮膚外用剤およびヒアルロニダーゼ阻害剤
KR101436819B1 (ko) 피부 보습, 진정 및 여드름 개선용 화장료 조성물

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22948092

Country of ref document: EP

Kind code of ref document: A1