WO2023241182A1 - Transducteur ultrasonore pour aider à la thrombolyse, et appareil de génération d'ultrasons le comprenant - Google Patents

Transducteur ultrasonore pour aider à la thrombolyse, et appareil de génération d'ultrasons le comprenant Download PDF

Info

Publication number
WO2023241182A1
WO2023241182A1 PCT/CN2023/087193 CN2023087193W WO2023241182A1 WO 2023241182 A1 WO2023241182 A1 WO 2023241182A1 CN 2023087193 W CN2023087193 W CN 2023087193W WO 2023241182 A1 WO2023241182 A1 WO 2023241182A1
Authority
WO
WIPO (PCT)
Prior art keywords
ultrasonic
radiating
ultrasonic transducer
thrombolysis
assisting
Prior art date
Application number
PCT/CN2023/087193
Other languages
English (en)
Chinese (zh)
Inventor
姚新科
黄定国
Original Assignee
深圳腾复医疗科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN202210668151.9A external-priority patent/CN115024788A/zh
Priority claimed from CN202221480054.9U external-priority patent/CN217960232U/zh
Application filed by 深圳腾复医疗科技有限公司 filed Critical 深圳腾复医疗科技有限公司
Publication of WO2023241182A1 publication Critical patent/WO2023241182A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for

Definitions

  • the present application relates to the technical field of medical devices, and in particular to an ultrasonic transducer used to assist thrombolysis and an ultrasonic generating device containing the same.
  • thrombotic diseases have become an important disease that threatens the health and life of all centuries. In addition to genetics, the occurrence of most thrombotic diseases is related to people's bad lifestyle and habits. Among thrombotic diseases, including ischemic cerebrovascular disease, myocardial infarction, pulmonary embolism, and various arteriovenous thrombosis caused by surgery or trauma, they have a high incidence rate and high mortality and disability rates. At present, the treatment and prevention of thrombotic diseases are mainly based on anticoagulation and thrombolytic therapy. Thrombolytic therapy mainly includes systemic thrombolytic therapy and catheter contact thrombolysis.
  • systemic thrombolytic treatment has the risk of causing cerebral hemorrhage or systemic hemorrhage; although catheter-contact thrombolysis reduces the dosage of thrombolytic drugs, the thrombolytic efficiency of thrombolytic drugs is still not ideal and the thrombolysis time is long. , and long-term catheter thrombolysis also carries the risk of infection.
  • the purpose of some embodiments of the present application is to provide an ultrasonic transducer for assisting thrombolysis and an ultrasonic generating device containing the same, which can convert electrical energy into ultrasonic energy, thereby accelerating the action of thrombolytic drugs through the combination of ultrasonic waves and thrombolytic drugs. , improve thrombolysis efficiency and shorten thrombolysis time.
  • the embodiment of the present application provides an ultrasonic transducer for assisting thrombolysis.
  • the ultrasonic transducer includes at least one ultrasonic radiating unit; the ultrasonic radiating unit includes:
  • an ultrasonic radiator an ultrasonic radiator; and a power transmission component, which is electrically connected to the ultrasonic radiator and used to transmit electrical energy to the ultrasonic radiator.
  • the ultrasonic radiator is in the form of a hollow cylinder; the outer wall and the inner wall of the hollow cylinder are used for the first electrode and the second electrode respectively.
  • the power transmission member includes a first wire and a second wire electrically connected to the first electrode and the second electrode respectively; there are multiple ultrasonic radiating units, and the multiple ultrasonic radiating units have the same structure; A plurality of the ultrasonic radiating units are connected end-to-end through the first wire and the second wire to form a row-type ultrasonic radiating unit group.
  • the ultrasonic radiator includes: two radiating plate bodies and a common electrode plate; the common electrode plate is disposed between the two radiating plate bodies and is electrically connected to the two radiating plate bodies.
  • the common electrode plate is in the shape of a flat plate, and the two radiating plate bodies are respectively attached and fixed to each other. on both sides of the common electrode plate.
  • the two radiating plate bodies are identical and rectangular, and the thickness of the two radiating plate bodies is greater than the thickness of the common electrode plate.
  • the power transmission component includes two electrode wires electrically connected to the two radiation plate bodies respectively and an electrode connecting plate extending from the common electrode plate; there are multiple ultrasonic radiating units, and the plurality of ultrasonic radiating units are The structures of the ultrasonic radiating units are the same, and a plurality of the ultrasonic radiating units are connected end to end through the electrode wires and electrode connecting plates to form a row-type ultrasonic radiating unit group.
  • the common electrode plate and the electrode connecting plate of the row-type ultrasonic radiation unit group are integrated.
  • the common electrode plate includes: a plate body; two support parts are respectively protruded from both ends of the side of the plate body facing any of the radiation plate bodies, and a vibration groove is formed between the two support parts.
  • the supporting surfaces of the two supporting parts are connected to the radiating panel body.
  • the power transmission component includes: two electrode wires electrically connected to the two radiation plate bodies respectively and a common electrode wire connected to the common electrode plate; there are multiple ultrasonic radiating units, and multiple ultrasonic wave
  • the radiation units have the same structure, and the plurality of ultrasonic radiation units are connected end to end through the electrode wires and the common electrode wires to form a column-type ultrasonic radiation unit group.
  • ultrasonic radiating units there are multiple ultrasonic radiating units, and the plurality of ultrasonic radiating units are connected end to end through the power transmission component to form a row-type ultrasonic radiating unit group.
  • Embodiments of the present application also provide an ultrasonic generating device for assisting thrombolysis, including: an ultrasonic transducer and a catheter for assisting thrombolysis as described above; the catheter is used to load the ultrasonic transducer device.
  • the ultrasonic generating device further includes an insulating structure
  • the insulating structure is an insulating layer that fills and wraps the ultrasonic transducer, or the conduit doubles as an insulating structure of the ultrasonic transducer.
  • the ultrasonic wave generating device further includes: a power module, the power module is electrically connected to the ultrasonic transducer.
  • the ultrasonic wave generating device further includes: a reinforcing member disposed in the conduit and used to enhance the axial strength of the ultrasonic transducer.
  • the reinforcing member is a reinforcing tube coaxially disposed within the ultrasonic radiator.
  • the ultrasonic transducer and ultrasonic generating device used to assist thrombolysis in the embodiment of the present invention transmit electric energy to the ultrasonic radiator through the power transmission part, and convert the electric energy into ultrasonic energy through the ultrasonic radiator and radiate ultrasonic waves, so that the ultrasonic waves can be used in blood tissue It spreads internally, accelerates the penetration of thrombolytic drugs into the interior of the thrombus, increases the interaction area between the drug and the thrombus, enhances the binding ability of the thrombolytic drugs to fibrin, and assists the thrombolytic drugs in cutting off the molecular connections within the thrombus fibers, thus accelerating the degradation of the fibrin matrix. , shorten the vascular recanalization time and improve the success rate of thrombolysis; at the same time, it can also reduce the dosage of thrombolytic drugs, thereby reducing the risk of bleeding caused by thrombolytic drugs.
  • Figure 1 is a schematic structural diagram of an ultrasonic radiation unit of an ultrasonic transducer for assisting thrombolysis provided in Embodiment 1 of the present invention
  • Figure 2 is a schematic structural diagram of an ultrasonic transducer for assisting thrombolysis provided in Embodiment 1 of the present invention. picture;
  • Figure 3 is a schematic structural diagram of an ultrasonic radiation unit of an ultrasonic transducer for assisting thrombolysis provided in Embodiment 2 of the present invention
  • Figure 4 is a schematic structural diagram of a radiation plate body of an ultrasonic transducer for assisting thrombolysis provided in Embodiment 2 of the present invention
  • Figure 5 is a schematic structural diagram of a common electrode plate of an ultrasonic transducer for assisting thrombolysis provided in Embodiment 2 of the present invention
  • Figure 6 is a schematic structural diagram of an ultrasonic transducer for assisting thrombolysis provided in Embodiment 2 of the present invention.
  • Figure 7 is a schematic structural diagram of an ultrasonic radiation unit of an ultrasonic transducer for assisting thrombolysis provided in Embodiment 3 of the present invention.
  • Figure 8 is a schematic structural diagram of a radiation plate body of an ultrasonic transducer for assisting thrombolysis provided in Embodiment 3 of the present invention.
  • Figure 9 is a schematic structural diagram of a common electrode plate of an ultrasonic transducer for assisting thrombolysis provided in Embodiment 3 of the present invention.
  • Figure 10 is a schematic structural diagram of an ultrasonic transducer for assisting thrombolysis provided in Embodiment 3 of the present invention.
  • Figure 11 is a schematic structural diagram of an ultrasonic generating device for assisting thrombolysis provided in Embodiment 4 of the present invention.
  • Figure 12 is a schematic cross-sectional structural diagram at A-A in Figure 11;
  • Figure 13 is a schematic cross-sectional structural diagram of the ultrasonic transducer and insulation structure
  • Figure 14 is a schematic diagram of another cross-sectional structure at AA in Figure 11.
  • connection and “connected” should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection, It can also be connected indirectly through an intermediary, which can be an internal connection between two components.
  • the proximal end refers to the end closer to the operator, and the distal end refers to the end farther from the operator;
  • the axial direction refers to the end parallel to the natural direction. The direction of the line connecting the distal center and the proximal center of the medical device in the state.
  • an embodiment of the present invention provides an ultrasonic transducer for assisting thrombolysis, which can be used in conjunction with thrombolytic drugs to radiate ultrasonic energy during thrombolysis, and can accelerate ultrasonic waves when they propagate in blood tissues.
  • thrombolytic drugs penetrate into the thrombus, increase the interaction area between the drug and the thrombus, and enhance the thrombolytic drugs.
  • the binding ability of the substance to fibrin and the auxiliary thrombolytic drugs can cut off the molecular connections within the thrombus fibers, thereby accelerating the degradation of the fibrin matrix, shortening the vascular recanalization time, and improving the success rate of thrombolysis; it can also reduce the use of thrombolytic drugs.
  • the ultrasonic transducer used to assist thrombolysis in this embodiment includes at least an ultrasonic radiating unit.
  • the ultrasonic radiating unit includes: an ultrasonic radiator and a power transmission component.
  • the power transmission component is electrically connected to the ultrasonic radiator and is used to transmit electrical energy to the ultrasonic radiator.
  • the ultrasonic radiator can be made of piezoelectric materials with piezoelectric effect, including but not limited to: lead zirconate titanate (PZT for short), barium titanate, lead titanate , lead metaniobate and other piezoelectric materials.
  • PZT lead zirconate titanate
  • barium titanate barium titanate
  • lead titanate lead titanate
  • lead metaniobate lead metaniobate
  • other piezoelectric materials including but not limited to: lead zirconate titanate (PZT for short), barium titanate, lead titanate , lead metaniobate and other piezoelectric materials.
  • Lead zirconate titanate is a solid solution of PbTiO3 and PbZrO3, which is especially suitable for making piezoelectric devices.
  • the power transmission parts can be wires, metal sheets and other structures suitable for conducting electricity.
  • the power transmission component is connected to an external power supply and applies an alternating current signal with a frequency above 20KHz to the ultrasonic radiator, causing the ultrasonic radiator to generate ultrasonic vibration and emit ultrasonic energy to the surroundings.
  • the ultrasonic transducer may include a plurality of ultrasonic radiating units, and the plurality of ultrasonic radiating units are connected end to end through power transmission parts to form a row-type ultrasonic radiating unit group.
  • the radiation range of a single ultrasonic radiating unit is limited and cannot meet the needs of use in a long thrombolysis section.
  • the length of the ultrasonic transducer can be increased, so that the length of the ultrasonic transducer can be increased according to the thrombolysis length.
  • Ultrasonic transducers of different lengths are required. It can be understood that the structures of the ultrasonic radiators of multiple ultrasonic radiating units may be the same or different, and are not specifically limited here.
  • the ultrasonic radiator 11 is in the form of a hollow cylinder.
  • the outer wall of the hollow cylinder is used for the first electrode 111
  • the inner wall of the hollow cylinder is used for the second electrode 112 .
  • the power transmission member includes a first conductor 12 electrically connected to the first electrode 111 and a second conductor 13 electrically connected to the second electrode 112 .
  • An alternating current signal with a frequency above 20 KHz is applied to the ultrasonic radiator 11 through the first wire 12 and the second wire 13, so that the outer wall (that is, the first electrode 111) as the ultrasonic radiation surface outputs ultrasonic vibrations outward.
  • the ultrasonic radiator 11 with a hollow cylindrical structure can emit ultrasonic waves in a radially outward radiation mode, so that it can act on the thrombus from all directions inside the blood vessel.
  • the ultrasonic transducer 1 for assisting thrombolysis in this embodiment includes multiple ultrasonic radiating units, and the multiple ultrasonic radiating units have the same structure.
  • a plurality of ultrasonic radiating units are connected end to end through the first wire 12 and the second wire 13 to form a row-type ultrasonic radiating unit group.
  • the ultrasonic transducer 1 includes n ultrasonic radiating units.
  • the first electrode 111 of the ultrasonic radiating body 11 of the first ultrasonic radiating unit The first electrodes 111 of the second, third,...n ultrasonic radiators 11 are connected in sequence through the first wires 12.
  • the second electrodes 112 of the first ultrasonic radiator 11 are connected to the second, third,...nth ultrasonic radiators 11.
  • the second electrodes 113 of the n ultrasonic radiators 11 are connected in sequence through the second wires 13 . Referring to FIG.
  • the ultrasonic transducer 1 includes three ultrasonic radiating units connected end to end through a first wire 12 and a second wire 13 to form a row-type ultrasonic radiating unit group. It can be understood that the number of ultrasonic radiating units can be determined according to the thrombolysis length and the length of a single ultrasonic radiating unit, and can be more, such as 9, etc., and is not specifically limited here.
  • the main difference between the ultrasonic transducer for assisting thrombolysis provided in the second embodiment of the present invention and the ultrasonic transducer of the first embodiment is that the specific structures of the ultrasonic radiator and the power transmission component are different. The details will not be repeated here.
  • the radiator includes: two radiating plates 21 and a common electrode plate 231 .
  • the common electrode plate 231 is disposed between the two radiating plate bodies 21 and is electrically connected to the two radiating plate bodies 21 .
  • the two radiating plates 21 are respectively used to convert electrical energy into ultrasonic vibration energy and emit ultrasonic energy.
  • the radiation plate body 21 is made of piezoelectric material.
  • the two radiating plates 21 may have the same structure, for example, the two radiating plates 21 may have the same shape and size.
  • the two radiation plate bodies 21 may both be rectangular.
  • Each radiation plate body 21 includes a first end surface 211 and a second end surface 212 .
  • the first end face 211 and the second end face 212 are both rectangular planes.
  • the first end face 211 or the second end face 212 is closely connected to the common electrode plate 231, and the free first end face or the second end face is used to output ultrasonic vibration energy.
  • the two radiating plate bodies 21 are arranged symmetrically with respect to the common electrode plate 231. Therefore, the ultrasonic radiator of this embodiment emits ultrasonic waves outward through the two symmetrical radiating surfaces during operation.
  • the common electrode plate 231 is in the shape of a flat plate.
  • the common electrode plate 231 is a metal electrode, which can be made of a metal material with good conductivity.
  • the common electrode plate 231 serves as the ground electrode of the two radiating plate bodies 21 .
  • the two radiation plate bodies 21 are respectively attached and fixed on both sides of the common electrode plate 231 .
  • the common electrode plate 231 and the radiation plate body 21 can be connected using conductive glue, which is not specifically limited here.
  • the power transmission component may include two electrode wires 22 electrically connected to the two radiation plate bodies 21 respectively and an electrode connection plate 232 formed by extending from the common electrode plate 231 .
  • the radiating surface of the radiating plate body 21 serves as its other electrode and is connected to the electrode wire 22 .
  • the electrode wire 22 extends in a direction parallel to the radiating plate body 21 .
  • the electrode connection plate 232 is used to connect to an external power supply or to the common electrode plates 231 of other ultrasonic radiation units.
  • the common electrode plate 231 and the electrode connection plate 232 are one piece and are used for the common electrode 230 of the ultrasonic radiation unit. It can be understood that the electrode connecting plate 232 can also be replaced by wires.
  • the thickness of the two radiation plate bodies 21 is greater than the thickness of the common electrode plate 231, so that the ultrasonic radiator has better radiation performance.
  • the ultrasonic transducer 2 of this embodiment may also include multiple ultrasonic radiating units.
  • the structures of the multiple ultrasonic radiating units may be the same, and the multiple ultrasonic radiating units are connected end to end through the electrode wires 22 and the electrode connecting plates to form a column-type ultrasonic radiating unit group.
  • the common electrode plate 231 and the electrode connecting plate 232 of the column-type ultrasonic radiating unit group can be an integrated piece, that is, the common electrodes 230 of multiple ultrasonic radiating units are integrated and used for one electrode 23 of the ultrasonic transducer 2 .
  • the ultrasonic transducer 2 includes n ultrasonic radiating units.
  • the ultrasonic radiator of the first ultrasonic radiating unit is connected to the second, third, ...
  • the common electrode of the ultrasonic radiation unit Please refer to Figure 6.
  • the ultrasonic transducer 2 includes a column-type ultrasonic radiating unit group consisting of three ultrasonic radiating units connected end to end.
  • the main difference between the ultrasonic transducer for assisting thrombolysis provided in the third embodiment of the present invention and the ultrasonic transducer of the second embodiment is that the structure of the common electrode plate of the ultrasonic radiator is different. The details will not be repeated here.
  • the ultrasonic radiator of the ultrasonic transducer includes: two radiating plates 31 and a common electrode plate 32 .
  • the common electrode plate 32 is disposed between the two radiating plate bodies 31 and is electrically connected to the two radiating plate bodies 31 .
  • the two radiating plates 31 are respectively used to convert electrical energy into ultrasonic vibration energy and emit ultrasonic energy.
  • the radiation plate body 31 is made of piezoelectric material.
  • the two radiating plate bodies 31 may have the same shape and size.
  • the two radiation plate bodies 31 may both be rectangular.
  • Each radiating plate body 31 includes a first end surface 311 and a second end surface 312 .
  • the first end surface 311 and the second end surface 312 are both rectangular planes, and the first end surface 311 or the second end surface 312 is connected to the common electrode plate 32 .
  • the common electrode plate 32 includes: a plate body 321 .
  • the side of the plate body 321 facing any radiation plate body 31 Two supporting portions 322 are respectively protruded from both ends.
  • a vibration groove 323 is formed between the two supporting portions 322 .
  • the supporting surfaces of the two supporting portions 322 are connected to the radiation plate body 31 .
  • the radiating plate body 31 is supported by the two supporting parts 322 and the vibration groove 323 serves as a gap between the radiating plate body 31 and the common electrode plate 32, so that each radiating plate body 31 can vibrate as a whole and output ultrasonic vibration, thereby being able to emit stronger of ultrasound.
  • the power transmission component includes: two electrode wires 33 electrically connected to the two radiation plate bodies 31 respectively, and a common electrode wire 34 connected to the common electrode plate 32 .
  • the radiation surface of the radiation plate body 31 away from the common electrode plate 32 serves as its other electrode and is connected to the electrode wire 33 .
  • the electrode wire 33 extends in a direction parallel to the radiation plate body 31 .
  • the ultrasonic transducer 3 of this embodiment may also include multiple ultrasonic radiating units.
  • the structures of multiple ultrasonic radiating units may be the same, and the multiple ultrasonic radiating units are connected end to end through electrode wires 33 and common electrode wires 34 to form a row-type ultrasonic radiating unit group.
  • the ultrasonic transducer 3 includes n ultrasonic radiating units, the ultrasonic radiator of the first ultrasonic radiating unit and the second, third,...n ultrasonic radiators are connected in sequence through the electrode wire 33 and the common electrode wire 34 .
  • the ultrasonic transducer 3 includes a column-type ultrasonic radiating unit group consisting of three ultrasonic radiating units connected end to end.
  • Embodiment 4 of the present invention provides an ultrasonic generating device for assisting thrombolysis.
  • the ultrasonic generating device of this embodiment includes an ultrasonic transducer 42 for assisting thrombolysis, a catheter 41 and a power module as described in any one of the first, second or third embodiments.
  • the ultrasonic transducer 42 used to assist thrombolysis is explained by taking the ultrasonic transducer described in Embodiment 1 as an example. It can be understood that the ultrasonic transducers mentioned in other embodiments herein are also applicable to the ultrasonic generating device of this embodiment.
  • the catheter 41 is used to load the ultrasonic transducer 42 so as to transport the loaded ultrasonic transducer 42 to the thrombolysis site.
  • the material of the conduit 41 includes but is not limited to polyvinyl chloride, polyimide, polyethylene, polytetrafluoroethylene, etc.
  • the ultrasonic generating device also includes an insulating structure, which is used to insulate the ultrasonic transducer 42 from the outside world, thereby ensuring the safety of use of the ultrasonic generating device 4 .
  • the insulating structure may adopt an insulating layer 43 that fills and wraps the ultrasonic transducer 42 .
  • the conduit 41 doubles as an insulating structure for the ultrasonic transducer 42 . It can be understood that other methods can also be used to achieve the insulation purpose of the ultrasonic transducer, and there is no specific limitation here.
  • the power module is electrically connected to the ultrasonic transducer 42 and is used to power the ultrasonic transducer 42 .
  • the power module may include: an energy source 45 and a cable 44 .
  • the energy source 45 and the ultrasonic transducer 42 are electrically connected through a cable 44 .
  • the cable 44 can be connected to the first conductor 12 and the second conductor 13 to provide electric energy.
  • the cable 44 can be connected correspondingly to its power transmission component, which will not be described again here.
  • the ultrasonic wave generating device 4 may further include: a reinforcing member 46 disposed in the conduit 41 and used to enhance the axial strength of the ultrasonic transducer 42 .
  • the reinforcing member 46 can be a reinforcing tube coaxially disposed within the ultrasonic radiator.
  • Reinforcement tubes can be made of metal or plastic. The reinforcing tube can be tightly matched with the ultrasonic radiator or there can be a radial gap between the two.
  • the shape of the enhancement tube may be circular, rectangular, triangular or other suitable shapes, and the length of the enhancement tube may be slightly greater than or equal to the length of the ultrasonic transducer 42 .
  • the shape of the reinforcing member 46 only needs to match the shape of the ultrasonic transducer 42 .
  • This embodiment places no specific restrictions on the structure, material and installation method of the reinforcement.
  • the axial stiffness of the ultrasonic transducer 42 is enhanced by the reinforcing member 46 to facilitate pushing the ultrasonic wave generating device 4 in the blood vessel.
  • the ultrasonic generating device 4 serves as an ultrasonic energy radiation component and can be placed at the intravascular treatment site to assist in dissolving thrombi.
  • the present invention has at least the following advantages and positive effects:
  • the ultrasonic transducer and ultrasonic generating device used to assist thrombolysis in the embodiment of the present invention transmit electric energy to the ultrasonic radiator through the power transmission part, and convert the electric energy into ultrasonic energy through the ultrasonic radiator and radiate ultrasonic waves, so that the ultrasonic waves can be used in blood tissue It spreads internally, accelerates the penetration of thrombolytic drugs into the interior of the thrombus, increases the interaction area between the drug and the thrombus, enhances the binding ability of the thrombolytic drugs to fibrin, and assists the thrombolytic drugs in cutting off the molecular connections within the thrombus fibers, thus accelerating the degradation of the fibrin matrix. , shorten the vascular recanalization time and improve the success rate of thrombolysis; at the same time, it can also reduce the dosage of thrombolytic drugs, thereby reducing the risk of bleeding caused by thrombolytic drugs.

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

L'invention concerne un transducteur ultrasonore (1, 2, 3, 42) pour aider à la thrombolyse, et un appareil de génération d'ultrasons (4) le comprenant. Le transducteur ultrasonore (1, 2, 3, 42) comprend au moins une unité de rayonnement ultrasonore. L'unité de rayonnement ultrasonore comprend : un corps de rayonnement ultrasonore (11) et une pièce de transmission de puissance. La pièce de transmission de puissance est électriquement connectée au corps de rayonnement ultrasonore (11) et est utilisée pour transmettre de l'énergie électrique au corps de rayonnement ultrasonore (11). Le transducteur ultrasonore (1, 2, 3, 42) comprend une pluralité d'unités de rayonnement ultrasonore. La pluralité d'unités de rayonnement ultrasonore sont reliées bout à bout au moyen des pièces de transmission de puissance de celles-ci pour former un groupe d'unités de rayonnement ultrasonore en colonne. L'invention concerne en outre un appareil de génération d'ultrasons (4), comprenant : un transducteur ultrasonore (1, 2, 3, 42) et un cathéter (41). Le cathéter (41) est utilisé pour porter le transducteur ultrasonore (1, 2, 3, 42). Le transducteur ultrasonore (1, 2, 3, 42) et l'appareil de génération d'ultrasons (4) le comprenant peuvent convertir l'énergie électrique en énergie ultrasonore, ce qui permet d'accélérer l'action d'un médicament thrombolytique par combinaison d'ultrasons et du médicament thrombolytique, d'améliorer l'efficacité de thrombolyse, de réduire le temps de thrombolyse et d'abaisser le risque de saignement provoqué par le médicament thrombolytique.
PCT/CN2023/087193 2022-06-14 2023-04-10 Transducteur ultrasonore pour aider à la thrombolyse, et appareil de génération d'ultrasons le comprenant WO2023241182A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN202210668151.9 2022-06-14
CN202210668151.9A CN115024788A (zh) 2022-06-14 2022-06-14 用于辅助溶栓的超声波换能器及包含其的超声波发生装置
CN202221480054.9 2022-06-14
CN202221480054.9U CN217960232U (zh) 2022-06-14 2022-06-14 用于辅助溶栓的超声波换能器及包含其的超声波发生装置

Publications (1)

Publication Number Publication Date
WO2023241182A1 true WO2023241182A1 (fr) 2023-12-21

Family

ID=89192135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2023/087193 WO2023241182A1 (fr) 2022-06-14 2023-04-10 Transducteur ultrasonore pour aider à la thrombolyse, et appareil de génération d'ultrasons le comprenant

Country Status (1)

Country Link
WO (1) WO2023241182A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040019318A1 (en) * 2001-11-07 2004-01-29 Wilson Richard R. Ultrasound assembly for use with a catheter
CN101869499A (zh) * 2009-04-27 2010-10-27 宋源 扰动型单导管外科器械
CN102238918A (zh) * 2008-09-03 2011-11-09 南洋理工大学 用于动脉血栓移除的微型乳化器
CN103330578A (zh) * 2013-07-19 2013-10-02 乐普（北京）医疗器械股份有限公司 一种次圆周式超声消融导管
CN105797286A (zh) * 2014-12-31 2016-07-27 上海形状记忆合金材料有限公司 一种互背向发射多声束超声组件
CN106037803A (zh) * 2016-06-27 2016-10-26 中国科学院苏州生物医学工程技术研究所 超声换能器阵列、超声介入治疗系统及超声消融导管
CN115024788A (zh) * 2022-06-14 2022-09-09 深圳腾复医疗科技有限公司 用于辅助溶栓的超声波换能器及包含其的超声波发生装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040019318A1 (en) * 2001-11-07 2004-01-29 Wilson Richard R. Ultrasound assembly for use with a catheter
CN102238918A (zh) * 2008-09-03 2011-11-09 南洋理工大学 用于动脉血栓移除的微型乳化器
CN101869499A (zh) * 2009-04-27 2010-10-27 宋源 扰动型单导管外科器械
CN103330578A (zh) * 2013-07-19 2013-10-02 乐普（北京）医疗器械股份有限公司 一种次圆周式超声消融导管
CN105797286A (zh) * 2014-12-31 2016-07-27 上海形状记忆合金材料有限公司 一种互背向发射多声束超声组件
CN106037803A (zh) * 2016-06-27 2016-10-26 中国科学院苏州生物医学工程技术研究所 超声换能器阵列、超声介入治疗系统及超声消融导管
CN115024788A (zh) * 2022-06-14 2022-09-09 深圳腾复医疗科技有限公司 用于辅助溶栓的超声波换能器及包含其的超声波发生装置

Similar Documents

Publication Publication Date Title
CN115024788A (zh) 用于辅助溶栓的超声波换能器及包含其的超声波发生装置
US20240165666A1 (en) Ultrasound transducer and method for making the same
JP2015503283A (ja) バッキング部材、超音波プローブおよび超音波画像表示装置
CN105728306B (zh) 十字形正交复合驱动压电管形换能器
JP2008022077A (ja) 超音波探触子
US11383271B2 (en) Ultrasound transducer
US20140167561A1 (en) Ultrasonic vibration apparatus
WO2023241182A1 (fr) Transducteur ultrasonore pour aider à la thrombolyse, et appareil de génération d'ultrasons le comprenant
JP2013119074A (ja) 超音波振動デバイスおよび超音波医療装置
JP2014011737A (ja) 超音波振動デバイス、超音波振動デバイスの製造方法および超音波医療装置
CN217960232U (zh) 用于辅助溶栓的超声波换能器及包含其的超声波发生装置
JP2606249Y2 (ja) 超音波探触子
JP6086742B2 (ja) 超音波振動デバイスおよび超音波医療装置
CN213312918U (zh) 超声波电导治疗仪的治疗头
JP7119099B2 (ja) 超音波振動子、超音波処置具、及び超音波振動子の製造方法
JPH06261908A (ja) 超音波送波器およびこの送波器を備えた結石破砕装置
CN110870781A (zh) 柔性超声波换能器阵列、聚焦换能器
CN219594730U (zh) 一种超声波器件及超声波装置
US10327736B1 (en) Ultrasound transducer arrays and associated systems and methods
Hynynen 5J-2 A Method to Control the Electrical Impedance of Phased Array Elements
JP7190028B2 (ja) 超音波放射器具及び超音波装置
JP2702990B2 (ja) 超音波振動子
WO2017005958A1 (fr) Construction de transducteur d'onde acoustique et procédé pour obtenir des ondes mécaniques
JP3494696B2 (ja) 電磁音響変換器
JP2012115585A (ja) アレイ型超音波送波器

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23822753

Country of ref document: EP

Kind code of ref document: A1