WO2023217170A1 - Utilisation d'un inhibiteur de btk pour le traitement d'une maladie - Google Patents
Utilisation d'un inhibiteur de btk pour le traitement d'une maladie Download PDFInfo
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- WO2023217170A1 WO2023217170A1 PCT/CN2023/093180 CN2023093180W WO2023217170A1 WO 2023217170 A1 WO2023217170 A1 WO 2023217170A1 CN 2023093180 W CN2023093180 W CN 2023093180W WO 2023217170 A1 WO2023217170 A1 WO 2023217170A1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Definitions
- the JAK inhibitor and the BTK inhibitor are administered simultaneously or sequentially, and the time interval of administration is limited to the extent that a synergistic effect can be achieved, and the time interval of administration can be determined by a skilled person.
- a subject is an individual diagnosed with, suspected of having, or susceptible to the disease or condition.
- the frequency of administration of the BTK inhibitor of the present disclosure can be once a day, twice a day, three times a day, once every two days, once every three days, once a week, etc.
- This experiment uses a urea nitrogen (BUN) test kit to detect the content of urea nitrogen in mouse serum.
- the experimental steps are as follows: (1) Take 10 ⁇ L double-distilled water as the blank control, 10 mmol/L BUN standard application solution as the standard sample, and add 10 ⁇ L serum of each group of mice into a 1.5 mL EP tube, and then add 125 ⁇ L buffer enzyme solution ; (2) After mixing, take a 37°C water bath for 10 minutes; (3) Add 500 ⁇ L of phenol chromogen and 500 ⁇ L of alkaline sodium hypochlorite to each sample in turn, mix thoroughly, and keep in a 37°C water bath for 10 minutes.
- BUN urea nitrogen
- the anti-dsDNA IgG content in the kidneys of mice in the 2.5 mg/kg Compound B (BID) + 1.5 mg/kg Compound A (QD) combination group was significantly lower than that in the blank group (P ⁇ 0.001); and the corresponding doses of Compound B or Compared with the compound A single drug group, the anti-dsDNA IgG content in the kidneys of mice in the combination group was significantly reduced (P ⁇ 0.05), indicating that 2.5 mg/kg compound B (BID) and 1.5 mg/kg compound A (QD) were used in combination , has a significant synergistic improvement effect on the deposition of anti-dsDNA IgG in the kidney.
- the estimated eGFR during screening (calculated using the CKD-EPI formula) is ⁇ 60mL/min/1.73m 2 .
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne l'utilisation d'un inhibiteur de BTK pour le traitement d'une maladie. Spécifiquement, la présente invention concerne l'utilisation de l'inhibiteur de BTK dans la préparation d'un médicament pour prévenir ou traiter une néphropathie membraneuse, une protéinurie, une néphropathie lupique ou une lésion rénale lupique.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210532478 | 2022-05-10 | ||
| CN202210532478.3 | 2022-05-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2023217170A1 true WO2023217170A1 (fr) | 2023-11-16 |
Family
ID=88729722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2023/093180 WO2023217170A1 (fr) | 2022-05-10 | 2023-05-10 | Utilisation d'un inhibiteur de btk pour le traitement d'une maladie |
Country Status (2)
| Country | Link |
|---|---|
| TW (1) | TW202408524A (fr) |
| WO (1) | WO2023217170A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024088315A1 (fr) * | 2022-10-26 | 2024-05-02 | Beigene, Ltd. | Méthodes de traitement d'une néphropathie membraneuse primaire |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016128912A1 (fr) * | 2015-02-12 | 2016-08-18 | Acerta Pharma B.V. | Combinaisons thérapeutiques d'un inhibiteur de btk, d'un inhibiteur de pi3k, d'un inhibiteur de jak-2, d'un inhibiteur de pd-1, et/ou d'un inhibiteur de pd-l1 |
| WO2021141919A1 (fr) * | 2020-01-06 | 2021-07-15 | Principia Biopharma Inc. | Traitement d'une néphropathie membraneuse, d'une maladie liée à igg4 et d'un syndrome d'antiphospholipides à l'aide d'un inhibiteur de btk 2-[(3r)-3-[4-amino-3-(2-fluoro-4-phénoxy-phényl)pyrazolo[3,4-d]pyrimidin-1-yl]pipéridine-1-carbonyl]-4-méthyl-4-[4-(oxétan-3-yl)pipérazin-1-yl]pent-2-ènenitrile |
| WO2022033460A1 (fr) * | 2020-08-10 | 2022-02-17 | 江苏恒瑞医药股份有限公司 | Utilisation d'inhibiteurs de btk dans le traitement de maladies |
-
2023
- 2023-05-10 WO PCT/CN2023/093180 patent/WO2023217170A1/fr unknown
- 2023-05-10 TW TW112117379A patent/TW202408524A/zh unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016128912A1 (fr) * | 2015-02-12 | 2016-08-18 | Acerta Pharma B.V. | Combinaisons thérapeutiques d'un inhibiteur de btk, d'un inhibiteur de pi3k, d'un inhibiteur de jak-2, d'un inhibiteur de pd-1, et/ou d'un inhibiteur de pd-l1 |
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| TW202408524A (zh) | 2024-03-01 |
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