WO2023202226A1 - 一种烟油基础油、电子烟烟油、电子烟及制备方法 - Google Patents

一种烟油基础油、电子烟烟油、电子烟及制备方法 Download PDF

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WO2023202226A1
WO2023202226A1 PCT/CN2023/079044 CN2023079044W WO2023202226A1 WO 2023202226 A1 WO2023202226 A1 WO 2023202226A1 CN 2023079044 W CN2023079044 W CN 2023079044W WO 2023202226 A1 WO2023202226 A1 WO 2023202226A1
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WIPO (PCT)
Prior art keywords
electronic cigarette
liquid
oil
nicotine
acid
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PCT/CN2023/079044
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English (en)
French (fr)
Inventor
周勇
杜振兴
宁静
邹婷婷
汤建国
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深圳麦克韦尔科技有限公司
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Publication of WO2023202226A1 publication Critical patent/WO2023202226A1/zh

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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor

Definitions

  • This application belongs to the technical field of electronic cigarettes, and specifically relates to a base oil for e-cigarettes, e-cigarette oil, electronic cigarettes and preparation methods.
  • E-cigarettes are electronic products that imitate cigarettes and have the same smoke, taste and feeling after smoking as cigarettes. As an emerging product, e-cigarettes have received great attention and extensive research from major domestic and foreign tobacco companies. The main reason is that on the one hand, e-cigarettes can provide consumption habits and satisfaction similar to traditional cigarettes, on the other hand, the hazard index of e-cigarettes is much lower than that of traditional cigarettes. Compared with traditional cigarettes, what people inhale into the human body is the atomized liquid of e-cigarette oil, rather than the cracking products produced by the combustion of traditional cigarettes. E-cigarettes do not burn and do not produce harmful substances such as tar, carbon monoxide, carbon dioxide, and acrolein. They cause almost no harm from second-hand smoke. Therefore, e-cigarettes are regarded as a pollution-free smoking cessation product or tobacco substitute.
  • the most common additive in e-cigarette oil is tobacco extract.
  • the tobacco extract obtained through extraction is mixed with propylene glycol, glycerin and flavor substances in a certain ratio, so as to simulate the aroma and fragrance of traditional cigarettes as much as possible. and taste.
  • most popular e-cigarette products on the market are e-liquids with a high nicotine content of 30-50mg/mL.
  • the technical problem to be solved by this application is to overcome the shortcomings of poor smoking satisfaction of e-liquids with a nicotine content of no more than 20 mg/mL in the prior art, thereby providing an e-liquid base oil, e-cigarette e-liquid, and e-cigarette. and preparation methods.
  • This application provides an e-liquid base oil, including nicotine and pseudoequisetine in a mass ratio of 20:(8-12).
  • This application also provides a kind of e-liquid, including the above-mentioned e-liquid base oil, with a nicotine content of less than 20 mg/g based on the total mass of the e-liquid.
  • the nicotine content is 18-20 mg/g.
  • the organic solvent is at least one of propylene glycol and glycerol.
  • the propylene glycol and glycerol are food grade or pharmaceutical grade products.
  • the fragrance substances include, but are not limited to, ⁇ -damascenone, pomeloone, ⁇ -damascenone, perillyl alcohol, citronellol, linalool, leaf alcohol, nerolidol, fragrance.
  • This application has no particular limitations on the source or extraction method of the aromatic substances.
  • the above aromatic substances can all be obtained through commercial channels.
  • the electronic cigarette oil includes 2% nicotine, 1% pseudoequisetine, 2% organic acid, 0-20% flavor substances, and 75-95% organic solvents.
  • the organic solvent is a mixture of propylene glycol and glycerol; and the fragrance substance is at least one of ⁇ -damascenone, pomeloone, and ⁇ -dihydrodamascenone.
  • This application provides a method for preparing the above-mentioned e-cigarette oil, which includes the following steps: weigh each raw material in proportion, mix, and dissolve at 50-70°C to obtain electronic cigarette oil.
  • This application also provides an electronic cigarette, including the above-mentioned electronic cigarette oil.
  • the e-liquid base oil provided by this application includes nicotine and pseudoequisetine in a mass ratio of 20:(8-12).
  • Using the e-liquid base oil formulated with nicotine and pseudoequisetine to configure e-cigarette e-liquid can break through the satisfaction bottleneck of the 20mg/g pure nicotine standard e-liquid, greatly improve the smoking power of e-cigarettes, and enhance the vaping experience of e-cigarettes. Suck contentment.
  • the e-liquid base oil provided by this application is used to configure the e-liquid with a nicotine content of 20mg/g.
  • the smoking satisfaction can reach the level of standard e-liquid with 25-30mg/g pure nicotine, and after 100 puffs, the e-liquid base oil provided by this application is used. Maintain the consistency of satisfaction.
  • the e-liquid base oil and e-liquid provided by this application can further enhance the satisfaction of smoking the e-liquid through the adjustment of the ratio of each component and the selection of components.
  • Figure 1 is a heart rate change diagram of test example 1 of this application.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • a kind of e-liquid calculated as 1000g, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • a kind of e-liquid calculated as 1000g, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is as follows: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until completely dissolved, to obtain the electronic cigarette oil.
  • An electronic cigarette liquid calculated on a 1000g basis, including the following components:
  • the preparation method is: weigh the above components in proportion, mix, and stir at 60°C for 1 hour until complete. When completely dissolved, the electronic cigarette oil is obtained.
  • the e-liquids of some examples and comparative examples were smoked by the tester through the "RELX" atomizer, and the tester's heart rate changes during the smoking process were measured. Three testers are selected, and the testers are required to have more than 3 years of experience in smoking traditional cigarettes and/or atomized e-cigarettes, and must have abstained from nicotine for at least 10 hours before the test. The final result is the average calculated value of 3 testers.
  • the smoking method adopts the overall circulation method, that is, when the smoke enters the mouth, it stays for about 3 seconds, then swallows the smoke through the throat, and then slowly exhales from the nasal cavity, that is, inhale, swallow, and exhale.
  • the heart rate measurement lasted for 10 minutes, starting at 1 minute between the start of the puff, 5 minutes during the puff, and continuing to 4 minutes after the end of the puff, with heart rate recorded every 10 seconds. In each condition, subjects were asked to take 10 puffs within 5 minutes of puffing, one puff every 30 seconds (3 seconds between puffs, 27 seconds apart).
  • Basal heart rate is defined as the average heart rate over the 1 minute period between puff onsets
  • normalized heart rate is defined as the ratio between individual heart rate points and basal heart rate.
  • Figure 1 is the heart rate test results from the Examples and Comparative Examples.
  • Example 6 The heart rate fluctuation of Example 6 is between Comparative Example 2 and Comparative Example 3, indicating that the satisfaction of the electronic cigarette oil (20 mg/g) provided by this application can reach the level of pure nicotine standard oil of 25-30 mg/g.
  • the smoking method adopts the overall circulation method, that is, when the smoke enters the mouth, it stays for about 3 seconds, then swallows the smoke through the throat, and then slowly exhales from the nasal cavity, that is, inhale, swallow, and exhale.
  • the e-cigarette device uses a "RELX" atomizer. Testers are required to have more than 3 years of experience in smoking traditional cigarettes and/or atomized e-cigarettes, and to have abstained from nicotine for at least 10 hours before the test.
  • the tester selects the one that he or she feels is more physiologically satisfying by smoking the e-cigarette liquids of the Example and the Comparative Example. Collect the answers of 15 testers, and then evaluate whether there is a significant difference in satisfaction between high-satisfaction e-liquid and various standard e-liquids according to the national standard GB/T 12310-2012.
  • the oil is configured into an e-liquid with a nicotine content of 20mg/g (18mg/g in Example 11), and its smoking satisfaction can also reach the level of standard e-liquid with 25-30mg/g pure nicotine, and after 100 puffs Keep contentment consistent.
  • the e-cigarette oil provided in Comparative Example 4 does not meet the corresponding industry standards due to its high nicotine content; Comparative Examples 5-7 do not use the e-cigarette oil formula provided by this application, and their smoking satisfaction is consistent with the 20mg/g pure nicotine standard.
  • the level of e-cigarette oil is equivalent and cannot improve the satisfaction of smoking; the e-cigarette oil of Comparative Example 8 does not contain nicotine, and the satisfaction of smoking is much lower than that of Comparative Example 1.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)

Abstract

本申请属于电子烟技术领域，具体涉及一种烟油基础油、电子烟烟油、电子烟及制备方法。本申请提供的烟油基础油，包括质量比为20:(8-12)的尼古丁和假木贼碱。使用尼古丁与假木贼碱共同配制的烟油基础油来配置电子烟烟油，可以突破20mg/g尼古丁的满足感瓶颈，大大改善电子烟抽吸的劲头，提升电子烟的抽吸满足感。经测试，采用本申请提供的烟油基础油配置成尼古丁含量为20mg/g的烟油，其抽吸满足感可达到25-30mg/g纯尼古丁标准烟油的水平，并在抽吸100口后保持满足感的一致性。

Description

一种烟油基础油、电子烟烟油、电子烟及制备方法
相关申请的交叉引用
本申请要求在2022年4月18日提交中国专利局、申请号为202210404976.X、发明名称为“一种烟油基础油、电子烟烟油、电子烟及制备方法”的中国专利申请的优先权，其全部内容通过引用的方式并入本文中。
技术领域
本申请属于电子烟技术领域，具体涉及一种烟油基础油、电子烟烟油、电子烟及制备方法。
背景技术
电子烟是一种模仿卷烟的电子产品，有着与卷烟一样的烟雾、味道和吸烟后感受。电子烟作为一种新兴产品，受到国内外各大烟草企业的高度关注和广泛研究。主要原因在于，一方面电子烟能够提供与传统卷烟类似的消费习惯和满足感，另一方面电子烟的危害指数比传统卷烟大大降低。与传统卷烟相比，人们吸入人体的是电子烟烟油的雾化液，而不是传统卷烟燃烧产生的裂解产物。电子烟不燃烧，也不会产生焦油、一氧化碳、二氧化碳及丙烯醛等有害物质，几乎不会带来二手烟的危害，因而电子烟被视为无公害的戒烟产品或烟草替代品。
目前，电子烟烟油最常见的添加物为烟草提取物，通过提取获得的烟草提取物与丙二醇、丙三醇和香味物质等按一定配比混合而成，如此能尽量模拟传统卷烟的香气、香味和口感。为了让电子烟使用者能够获得与传统卷烟一样的尼古丁满足感，使得市场上流行的电子烟产品多为30-50mg/mL的高尼古丁含量的烟油。
但是，近几年各国家各地区都在出台相应政策限制电子烟的尼古丁含量。例如，欧盟烟草产品指令(TPD)早在2014年就要求含有尼古丁的烟油中的尼古丁含量不得超过20mg/mL；加拿大的一项禁止尼古丁含量超过20mg/mL 的电子烟烟液规定已于2021年7月8日生效等。这些指令、规定期望通过降低烟油尼古丁含量来保护消费者免受高浓度尼古丁的成瘾性伤害，但这同时也大大打击了用户在体验电子烟时对抽吸满足感的需求，使得吸烟带来的快感降低。
有鉴于此，亟待开发一种尼古丁含量低，但是抽吸满足感大大提升的电子烟烟油。
发明内容
因此，本申请要解决的技术问题在于克服现有技术中的尼古丁含量不超过20mg/mL的烟油抽吸满足感差的缺陷，从而提供一种烟油基础油、电子烟烟油、电子烟及制备方法。
为此，本申请提供如下技术方案：
本申请提供一种烟油基础油，包括质量比为20:(8-12)的尼古丁和假木贼碱。
可选的，包括质量比为20:(9-11)的尼古丁和假木贼碱。
可选的，包括质量比为20:10的尼古丁和假木贼碱。
本申请还提供一种烟油，包括上述的烟油基础油，以烟油总质量计，尼古丁含量在20mg/g以下。
可选的，所述尼古丁含量在18-20mg/g。
可选的，包括如下质量百分含量的组分：烟油基础油2.5-3.2％，有机酸1.8-2.0％，有机溶剂75-95％，香味物质0-20％。
可选的，所述有机溶剂为丙二醇，丙三醇中的至少一种。例如，所述丙二醇、丙三醇均为食用级或药品级产品。
可选的，所述香味物质包括但不限于β-大马酮，圆柚酮，β-二氢大马酮，紫苏醇，香茅醇，芳樟醇，叶醇，橙花醇，香叶醇，β-苯乙醇，香茅醛，薄荷醇，苯甲醇，茄酮，香叶基丙酮，β-紫罗兰酮，柠檬醛，藏花醛，苯乙醛，己酸甲酯，己酸乙酯，己酸戊酯，己酸异戊酯，庚酸乙酯，苯甲酸甲酯，苯甲酸乙酯，异戊酸乙酯，异戊酸甲酯，水杨酸甲酯，异戊酸，3-甲基戊酸，α-水芹烯，柠檬烯，烟草提取物，可可提取物，咖啡提取物，薰衣草油，柠檬油，橘子油，八角茴香油中的至少一种。
本申请对香味物质的来源或提取方法没有特别限定，上述香味物质均可通过市售渠道获取。
通过采用上述香味物质对电子烟烟油的气味进行修饰，可以得到香气丰富、口感丰富和满足感较好的电子烟烟油。需要说明的是，上述香味物质与中草药提取物可以起到很好的协同复配效果，即两者共同赋予电子烟烟油具有香气丰富、口感丰富和满足感较好的优点。
可选的，所述电子烟烟油包括尼古丁2％，假木贼碱1％，有机酸2％，香味物质0-20％，有机溶剂75-95％。
可选的，所述有机溶剂为丙二醇和丙三醇的混合物；所述香味物质为β-大马酮，圆柚酮，β-二氢大马酮中的至少一种。
本申请提供一种上述的烟油的制备方法，包括如下步骤：按比例称取各原料，混合，在50-70℃下溶解，得到电子烟烟油。
本申请还提供一种电子烟，包括上述的电子烟烟油。
本申请技术方案，具有如下优点：
本申请提供的烟油基础油，包括质量比为20:(8-12)的尼古丁和假木贼碱。使用尼古丁与假木贼碱共同配制的烟油基础油来配置电子烟烟油，可以突破20mg/g纯尼古丁标准烟油的满足感瓶颈，大大改善电子烟抽吸的劲头，提升电子烟的抽吸满足感。经测试，采用本申请提供的烟油基础油配置成尼古丁含量为20mg/g的烟油，其抽吸满足感可达到25-30mg/g纯尼古丁标准烟油的水平，并在抽吸100口后保持满足感的一致性。
本申请提供的烟油基础油和烟油，通过对各组分配比的调整、组分的选择，能够进一步提升烟油的抽吸满足感。
附图说明
为了更清楚地说明本申请具体实施方式或现有技术中的技术方案，下面将对具体实施方式或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图是本申请的一些实施方式，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1是本申请测试例1的心率变化图。
具体实施方式
提供下述实施例是为了更好地进一步理解本申请，并不局限于所述最佳实施方式，不对本申请的内容和保护范围构成限制，任何人在本申请的启示下或是将本申请与其他现有技术的特征进行组合而得出的任何与本申请相同或相近似的产品，均落在本申请的保护范围之内。
实施例中未注明具体实验步骤或条件者，按照本领域内的文献所描述的常规实验步骤的操作或条件即可进行。所用试剂或仪器未注明生产厂商者，均为可以通过市购获得的常规试剂产品。
实施例1
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱12g，苯甲酸20g，薄荷醇5g，余量为丙二醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
实施例2
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱8g，苯甲酸20g，薄荷醇5g，余量为丙二醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
实施例3
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱11g，薄荷醇5g，苯甲酸20g，余量为丙二醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
实施例4
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱9g，薄荷醇5g，苯甲酸20g，余量为丙二醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
实施例5
一种烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱10g，薄荷醇5g，苯甲酸20g，余量为丙二醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
实施例6
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱10g，薄荷醇5g，苯甲酸20g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
实施例7
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱10g，薄荷醇5g，苯甲酸20g，余量为丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
实施例8
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱10g，香茅醛8g，苯甲酸20g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
实施例9
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱10g，薄荷醇8g，苯甲酸20g，余量为质量比为3：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
实施例10
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱10g，己酸异戊酯8g，苯甲酸20g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
实施例11
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁18g，假木贼碱10g，薄荷醇8g，苯甲酸18g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
对比例1
一种烟油，以1000g计，包括如下组分：
尼古丁20g，薄荷醇5g，苯甲酸20g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
对比例2
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁25g，薄荷醇5g，苯甲酸25g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
对比例3
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁30g，薄荷醇5g，苯甲酸30g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
对比例4
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁25g，假木贼碱5g，苯甲酸25g，薄荷醇5g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
对比例5
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，假木贼碱15g，苯甲酸20g，薄荷醇5g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
对比例6
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，异烟碱12g，苯甲酸20g，薄荷醇5g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
对比例7
一种电子烟烟油，以1000g计，包括如下组分：
尼古丁20g，可替宁12g，苯甲酸20g，薄荷醇5g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完全溶解，即得所述电子烟烟油。
对比例8
一种电子烟烟油，以1000g计，包括如下组分：
假木贼碱20g，薄荷醇5g，苯甲酸20g，余量为质量比为1：1的丙二醇和丙三醇。
其制备方法为：按比例称取上述各组分，混合，在60℃下搅拌1h至完 全溶解，即得所述电子烟烟油。
测试例
1、抽吸电子烟的心率研究
部分实施例与对比例的烟油通过“RELX”雾化器供测试者抽吸，对测试者在抽吸过程中的心率变化进行测定。选取3名测试者，要求测试者具有3年以上的传统卷烟与/或雾化电子烟抽吸经验，并在测试前戒断尼古丁至少10小时。最终结果为3名测试者的平均计算值。抽吸方式采用整体循环法，也就是当烟气进入口腔后停留3秒左右，再通过喉部将烟气吞咽下去，而后再从鼻腔徐徐呼出，即吸、吞、呼。心率测定的时间持续10分钟，从在抽吸开始之间的1分钟，在抽吸期间的5分钟，以及继续到抽吸结束后的4分钟，每隔10秒记录一次心率。在每种条件下，测试者被要求在抽吸的5分钟内进行10次抽吸，每30秒抽吸一次(抽吸3秒，间隔27秒)。基础心率被定义抽吸开始之间1分钟内的平均心率，归一化心率被定义为单独的心率点和基础心率间的比例。图1是来自实施例和对比例的心率测试结果，从图中可以看出，烟气在由肺部吸收进入血液后，烟气中物质(尼古丁/假木贼碱)能引起血液释放肾上腺素，而肾上腺素能使心跳加快、神经兴奋(这种神经兴奋就是“满足感”的一种表现)。实施例6的心率波动介于对比例2与对比例3之间，说明本申请提供的电子烟烟油(20mg/g)的满足感可达到25-30mg/g纯尼古丁标准烟油的水平。
2、抽吸电子烟的满足感研究
除了心率研究之外，还使用15名测试者对本申请实施例和对比例的烟油配方进行满足感品测。抽吸方式采用整体循环法，也就是当烟气进入口腔后停留3秒左右，再通过喉部将烟气吞咽下去，而后再从鼻腔徐徐呼出，即吸、吞、呼。电子烟的器具采用“RELX”雾化器。要求测试者具有3年以上的传统卷烟与/或雾化电子烟抽吸经验，并在测试前戒断尼古丁至少10小时。测试者通过抽吸实施例与对比例的电子烟烟油，选择他或她觉得的生理满足感更强的一项。收集15位测试者的答案，然后根据国家标准GB/T 12310-2012来评价高满足感烟油与各标准烟油之间是否存在满足感显著性差异。
经统计发现：如图1所示，抽吸本申请实施例6提供的电子烟烟油的满足感显著强于对比例1，而与对比例2和对比例3均无显著性差异，说明采 用本申请提供的烟油基础油配置成尼古丁含量为20mg/g的烟油，其抽吸满足感可达到25-30mg/g纯尼古丁标准烟油的水平，并在抽吸100口后保持满足感的一致性。另外，抽吸本申请其它实施例提供的电子烟烟油的满足感也显著强于对比例1，且与对比例2和对比例3均无显著性差异，说明采用本申请提供的烟油基础油配置成尼古丁含量为20mg/g(实施例11为18mg/g)的烟油，其抽吸满足感也可达到25-30mg/g纯尼古丁标准烟油的水平，并在抽吸100口后保持满足感的一致性。对比例4提供的电子烟烟油由于尼古丁含量高，不满足相应的行业标准；对比例5-7不采用本申请提供的电子烟烟油配方，其抽吸满足感与20mg/g纯尼古丁标准烟油的水平相当，不能提升抽吸满足感；对比例8的电子烟烟油中不含尼古丁，其抽吸满足感远低于对比例1。
显然，上述实施例仅仅是为清楚地说明所作的举例，而并非对实施方式的限定。对于所属领域的普通技术人员来说，在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引申出的显而易见的变化或变动仍处于本发明创造的保护范围之中。

Claims (11)

  1. 一种烟油基础油，其特征在于，包括质量比为20:(8-12)的尼古丁和假木贼碱。
  2. 根据权利要求1所述的烟油基础油，其特征在于，包括质量比为20:(9-11)的尼古丁和假木贼碱。
  3. 根据权利要求1所述的烟油基础油，其特征在于，包括质量比为20:10的尼古丁和假木贼碱。
  4. 一种电子烟烟油，其特征在于，包括权利要求1-3任一项所述的烟油基础油，以烟油总质量计，尼古丁含量在20mg/g以下。
  5. 根据权利要求4所述的电子烟烟油，其特征在于，以烟油总质量计，所述尼古丁含量在18-20mg/g。
  6. 根据权利要求4所述的电子烟烟油，其特征在于，包括如下质量百分含量的组分：烟油基础油2.5-3.2％，有机酸1.8-2.0％，有机溶剂75-95％，香味物质0-20％。
  7. 根据权利要求6所述的电子烟烟油，其特征在于，包括尼古丁2％，假木贼碱1％，有机酸2％，香味物质0-20％，有机溶剂75-95％。
  8. 根据权利要求6或7所述的电子烟烟油，其特征在于，所述有机溶剂为丙二醇，丙三醇中的至少一种；
    和/或，所述有机酸为苯甲酸，乙酰丙酸，乳酸中的至少一种。
  9. 根据权利要求6-8任一项所述的电子烟烟油，其特征在于，所述香味物质为β-大马酮，圆柚酮，β-二氢大马酮，紫苏醇，香茅醇，芳樟醇，叶醇， 橙花醇，香叶醇，β-苯乙醇，香茅醛，薄荷醇，苯甲醇，茄酮，香叶基丙酮，β-紫罗兰酮，柠檬醛，藏花醛，苯乙醛，己酸甲酯，己酸乙酯，己酸戊酯，己酸异戊酯，庚酸乙酯，苯甲酸甲酯，苯甲酸乙酯，异戊酸乙酯，异戊酸甲酯，水杨酸甲酯，异戊酸，3-甲基戊酸，α-水芹烯，柠檬烯，烟草提取物，可可提取物，咖啡提取物，薰衣草油，柠檬油，橘子油，八角茴香油中的至少一种。
  10. 一种权利要求4-9任一项所述的烟油的制备方法，其特征在于，包括如下步骤：按比例称取各原料，混合，在50-70℃下溶解，得到电子烟烟油。
  11. 一种电子烟，其特征在于，包括权利要求4-9任一项所述的电子烟烟油。
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