WO2023199586A1 - Peau artificielle à effet antimicrobien - Google Patents

Peau artificielle à effet antimicrobien Download PDF

Info

Publication number
WO2023199586A1
WO2023199586A1 PCT/JP2023/004214 JP2023004214W WO2023199586A1 WO 2023199586 A1 WO2023199586 A1 WO 2023199586A1 JP 2023004214 W JP2023004214 W JP 2023004214W WO 2023199586 A1 WO2023199586 A1 WO 2023199586A1
Authority
WO
WIPO (PCT)
Prior art keywords
layer
collagen
silicone
artificial skin
silver
Prior art date
Application number
PCT/JP2023/004214
Other languages
English (en)
Japanese (ja)
Inventor
一 松村
綾子 高見
綾乃 倉田
博 寺井
真理子 征矢
Original Assignee
株式会社ジーシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社ジーシー filed Critical 株式会社ジーシー
Publication of WO2023199586A1 publication Critical patent/WO2023199586A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin

Definitions

  • the present invention relates to artificial skin that has an antibacterial effect.
  • the present invention was made in view of the above-mentioned circumstances, and an object of the present invention is to provide an artificial skin that can prevent the growth of bacteria.
  • One aspect of the present invention includes a collagen layer containing collagen as a main component, and a silicone layer containing silicone as a main component and covering one surface of the collagen layer, wherein between the collagen layer and the silicone layer, the silicone It is an artificial skin in which only the layer contains antibacterial agents.
  • FIG. 1 is a perspective view of an artificial skin according to an embodiment of the present invention.
  • FIG. 2 is a cross-sectional view of a defective part of the skin or mucous membrane, illustrating how to use the artificial skin of FIG. 1, and shows the state before the artificial skin is transplanted.
  • FIG. 2 is a cross-sectional view of a defective part of the skin or mucous membrane, illustrating how to use the artificial skin of FIG. 1, and shows the state after the artificial skin is transplanted.
  • FIG. 2 is a cross-sectional view of a defective part of the skin or mucous membrane, illustrating a method of using the artificial skin of FIG. 1, and shows the state after the formation of a dermis-like tissue.
  • FIG. 2 is a cross-sectional view of a defective part of the skin or mucous membrane, illustrating a method of using the artificial skin of FIG. 1, after the silicone layer is removed.
  • the artificial skin 1 is a sheet-like member, and includes a collagen layer 2 containing collagen as a main component and a silicone layer 3 containing silicone as a main component.
  • the artificial skin 1 has a two-layer structure consisting of a collagen layer 2 and a silicone layer 3 laminated in the thickness direction of the artificial skin 1, and the silicone layer 3 covers one surface of the collagen layer 2.
  • the artificial skin 1 is applied to the defect A in the skin or mucous membrane where the dermis B is missing (see FIG. 2A).
  • the size of the artificial skin 1 is designed according to the defect A to which it is applied.
  • Collagen layer 2 is a sponge made of crosslinked collagen and does not contain glycosaminoglycan. Collagen is crosslinked only by thermal crosslinking.
  • the collagen constituting the collagen layer 2 is a mixture of fibrotic atelocollagen and heat-denatured atelocollagen.
  • the silicone layer 3 has two first layers 4 made of silicone rubber and a second layer 5 arranged between the two first layers 4 and having a mesh structure.
  • the first layer 4 contains silver as an antibacterial agent 6, preferably 0.01% to 10% by weight of silver sulfate. Silver is supported in the first layer 4 in the form of particles and dispersed within the silicone.
  • the second layer 5 is made of a mesh sheet made of plastic such as PET (polyethylene terephthalate).
  • the tensile strength of the second layer 5 is higher than that of the first layer 4.
  • the artificial skin 1 has one or more drain holes 7 that penetrate the collagen layer 2 and the silicone layer 3 in the thickness direction.
  • the drain hole 7 is a passage through which exudate and hematoma accumulated in the defect A are drained from the body.
  • the drain hole 7 may have a shape other than a slit.
  • a base agent made of liquid silicone, a hardening agent, and silver as an antibacterial agent 6 (for example, 0.01 wt% to 10 wt% silver sulfate based on the total weight of the base agent, hardening agent, and silver sulfate) are added.
  • the resulting silicone mixture is formed into a sheet with a thickness of about 200 ⁇ m.
  • the mesh sheet 5 is embedded in a sheet-shaped silicone mixture, and then the silicone mixture is composited with an uncrosslinked collagen sponge. This yields a composite of silicone mixture and collagen sponge.
  • a drain hole 7 is drilled in the composite using a knife.
  • the artificial skin 1 is obtained by heat-treating the composite at about 110° C. in a vacuum to thermally crosslink the atelocollagen.
  • the artificial skin 1 is transplanted into the defect A of the skin or mucous membrane. Specifically, the artificial skin 1 is attached to the defect A so that the collagen layer 2 contacts the wound surface C, and the edges of the artificial skin 1 are attached to the defect A using sutures, staplers, etc. sutured to the surrounding skin. Since the artificial skin 1 has sufficient tensile strength due to the mesh sheet 5 within the silicone layer 3, the artificial skin 1 is prevented from tearing during suturing.
  • the collagen layer 2 within the defect A is maintained in a moist state by the silicone layer 3 covering the outside of the collagen layer 2.
  • the silicone layer 3 covering the outside of the collagen layer 2.
  • cells and capillaries invade the collagen layer 2 from around the defect A, and the cells construct a dermis-like tissue D in the defect A, while the collagen layer 2 is gradually absorbed by the living body.
  • the collagen layer 2 is gradually replaced with dermis-like tissue D.
  • exudate and hematoma accumulated in the defect A are discharged to the outside of the silicone layer 3 via the drain hole 7.
  • the silver contained in the silicone layer 3 comes into contact with the exudate, it releases silver ions, and the silver ions exert an antibacterial effect on the collagen layer 2 and/or the silicone layer 3.
  • the silicone layer 3 is removed by peeling from the surface of the dermis-like tissue D, and if necessary, a split-thickness skin graft is placed on the surface of the dermis-like tissue D. will be held.
  • the defect A where the artificial skin 1 has been transplanted is shielded from the outside by the silicone layer 3, and the silicone layer 3 prevents bacteria from entering the defect A from the outside.
  • the silicone layer 3 contains silver as the antibacterial agent 6, and silver ions released from the silver exhibit an antibacterial effect. Thereby, infection of the defective part A from the outside can be effectively prevented. Furthermore, the antibacterial action of silver ions released from silver can prevent the growth of bacteria on the collagen layer 2 and/or the silicone layer 3.
  • the antibacterial agent 6 contained in the silicone layer 3 can effectively suppress the growth of bacteria near the interface between the collagen layer 2 and the silicone layer 3.
  • the silicone layer 3 and the antibacterial agent 6 contained therein continue to stably exist outside the defect A throughout the period until the silicone layer 3 is removed. . Therefore, the antibacterial effect can continue to be stably exhibited throughout the period until the dermis-like tissue D is formed.
  • antibacterial agents such as silver can generally affect cells and tissues.
  • the antibacterial agent 6 is not contained in the collagen layer 2 but only in the outer silicone layer 3. Thereby, the antibacterial agent 6 can be prevented from affecting the formation of the dermis-like tissue D. Furthermore, after the dermis-like tissue D is formed, the antibacterial agent 6 is removed from the repaired defect A along with the silicone layer 3 and does not remain in the living body. Therefore, the influence of the antibacterial agent 6 on cells and tissues can be further suppressed.
  • the silicone layer 3 contains silver sulfate as the antibacterial agent 6, but instead may contain other types of silver commonly used as an antibacterial agent.
  • the silicone layer 3 may contain silver nitrate or silver sulfadiazine (SSD).
  • the silicone layer 3 may contain other types of antibacterial agents instead of or in addition to silver.
  • the second layer 5 is made of a mesh sheet made of plastic such as PET, but the second layer 5 is made of a mesh sheet made of another material having biocompatibility, flexibility, and high tensile strength. It may be a sheet.
  • the collagen layer 2 is made of fibrotic atelocollagen and heat-denatured atelocollagen, but the collagen constituting the collagen layer 2 may be other types of collagen commonly used in artificial skin.
  • the collagen may be atelocollagen that has not undergone either fibrosis or heat denaturation, or may be collagen from which telopeptide has not been removed.
  • the collagen of the collagen layer 2 is crosslinked only by thermal crosslinking, but the collagen may be crosslinked by other methods.
  • collagen may be crosslinked by chemical crosslinking with a crosslinking agent instead of or in addition to thermal crosslinking.
  • the artificial skin 1 has the drain hole 7, but the artificial skin 1 does not need to have the drain hole 7.
  • a user such as a doctor may make a drain hole in the artificial skin 1 using an instrument such as a scalpel.
  • the silicone layer 3 has the second layer 5 having a mesh structure, but it does not need to have the second layer 5.
  • the silicone layer 3 may be composed of only a single first layer 4.
  • the collagen layer 2 may appropriately contain additives such as glycosaminoglycan in addition to collagen as a main component.
  • the silicone layer 3 may contain arbitrary additives in addition to silicone and an antibacterial agent as main components.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

Une peau artificielle (1) comprend une couche de collagène (2), qui est principalement composée de collagène, et une couche de silicone (3), qui est principalement composée de silicone et recouvre une surface de la couche de collagène (2). Parmi la couche de collagène (2) et la couche de silicone (3), seule la couche de silicone (3) contient un agent antimicrobien (6).
PCT/JP2023/004214 2022-04-14 2023-02-08 Peau artificielle à effet antimicrobien WO2023199586A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2022066810A JP2023157117A (ja) 2022-04-14 2022-04-14 抗菌効果を有する人工皮膚
JP2022-066810 2022-04-14

Publications (1)

Publication Number Publication Date
WO2023199586A1 true WO2023199586A1 (fr) 2023-10-19

Family

ID=88329230

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2023/004214 WO2023199586A1 (fr) 2022-04-14 2023-02-08 Peau artificielle à effet antimicrobien

Country Status (3)

Country Link
JP (1) JP2023157117A (fr)
TW (1) TW202345919A (fr)
WO (1) WO2023199586A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989008465A1 (fr) * 1988-03-09 1989-09-21 Terumo Kabushiki Kaisha Substance medicale dans laquelle les cellules peuvent penetrer et peau artificielle
JPH05192363A (ja) * 1991-11-07 1993-08-03 Terumo Corp 創傷被覆材
CN106853263A (zh) * 2017-02-16 2017-06-16 深圳齐康医疗器械有限公司 一种人工皮肤及其制备方法
US20220031446A1 (en) * 2018-09-19 2022-02-03 Shenzhen Tsingcare Medical Instruments Co., Ltd. Artificial dermis repair material and preparation method therefor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989008465A1 (fr) * 1988-03-09 1989-09-21 Terumo Kabushiki Kaisha Substance medicale dans laquelle les cellules peuvent penetrer et peau artificielle
JPH05192363A (ja) * 1991-11-07 1993-08-03 Terumo Corp 創傷被覆材
CN106853263A (zh) * 2017-02-16 2017-06-16 深圳齐康医疗器械有限公司 一种人工皮肤及其制备方法
US20220031446A1 (en) * 2018-09-19 2022-02-03 Shenzhen Tsingcare Medical Instruments Co., Ltd. Artificial dermis repair material and preparation method therefor

Also Published As

Publication number Publication date
TW202345919A (zh) 2023-12-01
JP2023157117A (ja) 2023-10-26

Similar Documents

Publication Publication Date Title
ES2246200T3 (es) Implante protesico.
US3903882A (en) Composite dressing
AU643058B2 (en) Wound-covering materials
WO1996003091A1 (fr) Produit chirurgical et son utilisation
EP3424541A1 (fr) Matériau composite de réparation de tissu mou destiné à stabiliser une région de réparation
JPH07116242A (ja) 医用材料及びその製造方法
EP2648774A1 (fr) Greffe implantable piquée
CN102170920A (zh) 制造脱细胞基质胶的方法
KR20140146034A (ko) 이어 드럼 복원용 장치
JP2003513749A (ja) 外科的処置後に神経を保護するための装置
JPH10503099A (ja) 腹壁のための人工器官
KR20130101872A (ko) 골조직 재생유도용 차폐막
JP3726280B2 (ja) 医療用コラーゲン膜
Silveira et al. Bioprosthetic mesh of bacterial cellulose for treatment of abdominal muscle aponeurotic defect in rat model
JP2000511446A (ja) 創傷用包帯
WO2023199586A1 (fr) Peau artificielle à effet antimicrobien
DE102007063214A1 (de) Flächiges Implantat, insbesondere zur Hernienversorgung
JP7429996B2 (ja) 微小構造を含む組織処置デバイス
WO1989008466A1 (fr) Substance medicale dans laquelle les cellules peuvent penetrer et peau artificielle
Schachern et al. Experimental grafting of the round window membrane: Part I
Sanjana et al. Healing and hearing results of temporalis fascia graft Vs cartilage graft (Full thickness and half thickness) in type I tympanoplasty
US20090234305A1 (en) Temporary skin substitute comprised of biological compounds of plant and animal origins
RU220031U1 (ru) Биологический чехол для имплантируемых электронных устройств
JP2003245341A (ja) 癒着防止膜
US20230056628A1 (en) Healing tape

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23788009

Country of ref document: EP

Kind code of ref document: A1