WO2023153320A1 - 血管可視化部材、血管可視化装置、血管穿刺システム及び血管可視化システム - Google Patents

血管可視化部材、血管可視化装置、血管穿刺システム及び血管可視化システム Download PDF

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Publication number
WO2023153320A1
WO2023153320A1 PCT/JP2023/003491 JP2023003491W WO2023153320A1 WO 2023153320 A1 WO2023153320 A1 WO 2023153320A1 JP 2023003491 W JP2023003491 W JP 2023003491W WO 2023153320 A1 WO2023153320 A1 WO 2023153320A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood vessel
vessel visualization
sheet body
wavelength conversion
visualization member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2023/003491
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
妻木翔太
横田崇之
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to JP2023580215A priority Critical patent/JPWO2023153320A1/ja
Publication of WO2023153320A1 publication Critical patent/WO2023153320A1/ja
Priority to US18/787,700 priority patent/US12465699B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/427—Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G06T7/0014—Biomedical image inspection using an image reference approach
    • G06T7/0016—Biomedical image inspection using an image reference approach involving temporal comparison
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/20—Cameras or camera modules comprising electronic image sensors; Control thereof for generating image signals from infrared radiation only
    • H04N23/21—Cameras or camera modules comprising electronic image sensors; Control thereof for generating image signals from infrared radiation only from near infrared [NIR] radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A61M2205/3313—Optical measuring means used specific wavelengths
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10048—Infrared image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30101—Blood vessel; Artery; Vein; Vascular

Definitions

  • the present invention relates to a blood vessel visualization member, a blood vessel visualization device, a blood vessel puncture system, and a blood vessel visualization system.
  • Japanese Unexamined Patent Application Publication No. 2017-64094 discloses a vein visualization device.
  • a vein visualization device includes an irradiation unit, an imaging unit, an image processing unit, and a display unit.
  • the irradiation unit irradiates near-infrared light to a puncture target site of a patient.
  • the imaging unit acquires a captured image of the puncture target site by receiving reflected light from the puncture target site, out of the near-infrared light emitted to the puncture target site.
  • the image processing means extracts veins from the captured image.
  • the display unit displays the image processed by the image processing means.
  • the vein visualization device described above requires a member that converts near-infrared light into an image, so there is the problem of a large size and complicated configuration.
  • An object of the present invention is to solve the above-mentioned problems.
  • a first aspect of the present invention is a blood vessel visualization member for visualizing blood vessels in a living body, comprising a sheet body that can be attached to the surface of a visualization target site, wherein the sheet body has a near-infrared
  • a wavelength converting portion including a wavelength converting material that converts light into visible light, and an adhesive portion provided on the wavelength converting portion are provided.
  • the sheet body has flexibility.
  • the blood vessel visualization member according to any one of items (1) to (4), wherein the sheet body is configured to be permeable to liquid or gas in the thickness direction of the sheet body. is preferred.
  • the sheet body preferably has a puncture hole for puncturing the blood vessel with a medical device.
  • the sheet body has a fragile portion extending from the outer circumference of the sheet body to the puncture hole.
  • the wavelength conversion part includes a support layer formed in a sheet shape from a material that does not contain the wavelength conversion material. and a conversion section main body laminated on the support layer and made of a material containing the wavelength conversion material.
  • the conversion portion main body is formed by coating the surface of the support layer.
  • the blood vessel visualization member according to any one of items (1) to (10), wherein the wavelength conversion material converts the near-infrared light having a wavelength greater than 700 nm and 2500 nm or less to 400 nm or more and 700 nm. It is preferable to convert to said visible light of the following wavelengths.
  • a second aspect of the present invention is a blood vessel visualization device, comprising: the blood vessel visualization member according to any one of items (1) to (11); and an irradiation unit including a light source unit for irradiating the near-infrared light onto a surface opposite to the surface to which the is attached.
  • the irradiation unit has an irradiation support unit that supports the light source unit in a displaceable manner.
  • a third aspect of the present invention is a blood vessel puncture system, comprising: the blood vessel visualization device according to item (12) or (13); and a medical device that punctures the blood vessel.
  • a fourth aspect of the present invention is a blood vessel visualization system, comprising: the blood vessel visualization device according to item (12) or (13); and a camera for capturing a blood vessel image displayed on the blood vessel visualization member. and an image processing unit that analyzes an image captured by the camera.
  • the sheet body having the wavelength conversion section is attached to the surface of the visualization target site, near-infrared light transmitted through the visualization target site can be converted into visible light by the wavelength conversion section.
  • a visible blood vessel image can be displayed on the wavelength conversion unit.
  • the blood vessel visualization member can display a blood vessel image on the visualization target site without using a member that converts near-infrared light into an image. Therefore, blood vessels can be visualized with a small and simple configuration.
  • the blood vessel visualization member is attached to the surface of the visualization target site, the near-infrared light transmitted through the visualization target site can be efficiently received by the wavelength conversion section. Therefore, the blood vessel image can be displayed more clearly on the wavelength conversion unit.
  • FIG. 1 is a schematic configuration explanatory diagram of a blood vessel visualization system according to one embodiment of the present invention.
  • 2A is a bottom view of the vessel visualization device of FIG. 1;
  • FIG. 2B is a plan view of the vessel visualization device of FIG. 1;
  • FIG. 3 is a cross-sectional view along line III-III of FIG. 2B.
  • FIG. 4 is a schematic configuration explanatory diagram of a blood vessel puncture system according to one embodiment of the present invention.
  • FIG. 5A is a cross-sectional explanatory diagram of a blood vessel visualization member according to a first modification.
  • FIG. 5B is a cross-sectional explanatory diagram of a blood vessel visualization member according to a second modification.
  • FIG. 5C is a cross-sectional explanatory diagram of a blood vessel visualization member according to a third modification.
  • a blood vessel visualization system 12 includes a blood vessel visualization device 13A, a camera 14 and an information processing device 16.
  • the blood vessel visualization device 13A visualizes the blood vessel 302 (see FIG. 3) of the visualization target region 300 of the living body.
  • the visualization target part 300 is a human hand.
  • the visualization target part 300 may be a part such as a forearm, an upper arm, a leg, a lower leg, and a thigh of a human body.
  • the blood vessel visualization device 13A includes a blood vessel visualization member 10A and an irradiation unit 20.
  • the blood vessel visualization member 10A includes a sheet body 22 that can be adhered to the surface of the visualization target region 300. As shown in FIG. When the visualization target region 300 is a human hand, the sheet body 22 is attached to the back of the hand. The sheet body 22 has flexibility so that it can follow the surface shape of the visualization target region 300 .
  • the sheet body 22 is formed in a square shape when viewed from the thickness direction of the sheet body 22.
  • the length of one side of the sheet body 22 is set to, for example, 20 mm or more and 300 mm or less.
  • the thickness of the sheet body 22 is set to, for example, 0.1 mm or more and 0.5 mm or less.
  • the sheet body 22 is configured to be permeable to both liquid and gas in the thickness direction of the sheet body 22 .
  • the sheet body 22 has a plurality of fine permeation holes (not shown) through which liquid and gas can pass.
  • the sheet body 22 may be configured such that the liquid permeates in the thickness direction of the sheet body 22 and the gas does not permeate the sheet body 22 .
  • the sheet body 22 may be configured such that gas is permeable in the thickness direction of the sheet body 22 and liquid is impermeable. The sheet body 22 only needs to be permeable to liquid or gas in the thickness direction of the sheet body 22, and the permeation holes are not essential.
  • the shape and size of the sheet body 22 can be set as appropriate.
  • the sheet body 22 may be formed, for example, in a shape along the surface shape of the visualization target region 300 when viewed from the thickness direction of the sheet body 22 .
  • the sheet body 22 may be formed in a circular shape or a polygonal shape (other than a square shape) when viewed from the thickness direction of the sheet body 22 .
  • the sheet body 22 has a wavelength converting portion 24 and an adhesive portion 26.
  • the wavelength conversion section 24 may be transparent or opaque.
  • the wavelength conversion section 24 includes a wavelength conversion material 28 (optical up-conversion material) that converts near-infrared light L1 into visible light L2.
  • the wavelength conversion material 28 converts the near-infrared light L1 with a wavelength greater than 700 nm and 2500 nm or less into visible light L2 with a wavelength of 400 nm or more and 700 nm or less.
  • Wavelength converting material 28 includes, for example, an inorganic-based optical upconversion emitter or an organic-based optical upconversion emitter.
  • Inorganic-based optical upconversion phosphors have, for example, rare earth elements.
  • Organic-based optical upconversion emitters include, for example, organometallic complexes or polycyclic aromatic compounds.
  • the wavelength converting portion 24 is formed in a sheet shape from a material containing the wavelength converting material 28 .
  • the “material containing the wavelength conversion material 28” includes a material consisting only of the wavelength conversion material 28 and a mixed material in which the wavelength conversion material 28 is mixed with another material.
  • the wavelength conversion part 24 is formed into a sheet shape by using only the wavelength conversion material 28, for example.
  • the wavelength conversion part 24 may be formed in a sheet shape from a mixed material.
  • the bonding portion 26 is provided in layers on the surface of the wavelength converting portion 24 facing the thickness direction.
  • the bonding portion 26 is formed by applying an adhesive (adhesive) to the surface of the wavelength converting portion 24 .
  • an adhesive for example, an acrylic, rubber (natural rubber, synthetic rubber), silicone, urethane, or vinyl ether adhesive is used.
  • the adhesive portion 26 may be an adhesive sheet.
  • the adhesive portion 26 may be transparent or opaque.
  • the adhesive portion 26 transmits the near-infrared light L1.
  • the bonding portion 26 is provided over the entire surface of the wavelength converting portion 24 facing the thickness direction. However, the bonding portion 26 may be provided only on part of the surface of the wavelength conversion portion 24 . In this case, the adhesive part 26 may be one continuous member, or may have a plurality of members separated from each other.
  • a bonding surface 30 of the bonding portion 26 facing in the opposite direction to the wavelength converting portion 24 is provided with minute unevenness (not shown). This makes it easier to bring the adhesive surface 30 into close contact with the visualization target site 300 than when the adhesive surface 30 is formed flat.
  • the sheet body 22 is provided with a plurality of notches 32 that are connected to the outer circumference of the sheet body 22 .
  • the plurality of notches 32 are provided at each corner of the sheet body 22 and at the center of two sides facing each other.
  • Each notch 32 is one continuous slit.
  • the length of the notch 32 is set to, for example, 1 mm or more and 30 mm or less. The cut portion 32 penetrates the sheet body 22 in the thickness direction.
  • the notch 32 is not limited to an example extending linearly, and may be triangular, semicircular, quadrangular, or the like. Only one cut portion 32 may be provided in the sheet body 22 . The position, size, and shape of the notch 32 can be set as appropriate. That is, the notch 32 may be provided on each side of the sheet body 22 .
  • the irradiation section 20 has a substrate 34, a plurality of light source sections 36, an irradiation support section 38, a power supply line 40 and a power supply section .
  • the substrate 34 has flexibility.
  • a plurality of light source units 36 are attached to the substrate 34 .
  • Each light source unit 36 emits near-infrared light L1 having a wavelength greater than 700 nm and 2500 nm or less.
  • the light source unit 36 is, for example, a so-called chip-type light emitting diode.
  • the light source unit 36 may be a so-called lamp-type light-emitting diode or an organic light-emitting diode (OLED).
  • the number, arrangement, size and shape of the light source units 36 can be changed as appropriate.
  • the irradiation support part 38 supports the substrate 34 so as to be deformable. In other words, the irradiation support section 38 supports the plurality of light source sections 36 so as to be displaceable.
  • a power supply line 40 supplies power from a power supply unit 42 to each light source unit 36 .
  • the power supply line 40 connects the power supply section 42 and the substrate 34 to each other.
  • the power supply unit 42 is, for example, a primary battery or a secondary battery (battery).
  • the irradiation unit 20 may be configured to wirelessly supply power from the power supply unit 42 to each light source unit 36 . In this case, the power supply line 40 becomes unnecessary.
  • the camera 14 captures a later-described blood vessel image 400 displayed on the wavelength conversion unit 24 .
  • the camera 14 transmits the captured image to the information processing device 16 .
  • the camera 14 is wired to the information processing device 16 .
  • the camera 14 may be wirelessly connected to the information processing device 16 .
  • the camera 14 may transmit the captured image to the information processing device 16 via the Internet line.
  • the information processing device 16 includes an arithmetic unit 50, a storage unit 52, a display unit 54, and a speaker 56.
  • the calculation unit 50 is configured by a processor (processing circuit) such as a CPU (Central Processing Unit), a GPU (Graphics Processing Unit), or the like.
  • the calculation unit 50 includes a control unit 58 and an image processing unit 60.
  • the calculation unit 50 implements a control unit 58 and an image processing unit 60 by executing programs stored in the storage unit 52 .
  • the calculation unit 50 may realize at least part of the control unit 58 and the image processing unit 60 by an integrated circuit. Examples of integrated circuits include ASICs (Application Specific Integrated Circuits) and FPGAs (Field-Programmable Gate Arrays).
  • the storage unit 52 includes a volatile memory and a nonvolatile memory.
  • Volatile memory includes, for example, RAM (Random Access Memory). This volatile memory is used as a working memory of the processor and temporarily stores data required for processing or calculation. Examples of nonvolatile memory include ROM (Read Only Memory) and flash memory. This non-volatile memory is used as storage memory. Programs, tables, maps, and the like are stored in the nonvolatile memory. At least a portion of memory 52 may be incorporated into a processor or integrated circuit such as those described above.
  • the control unit 58 controls the entire information processing device 16 .
  • the control unit 58 causes the storage unit 52 to store the image received from the camera 14 .
  • the image processing unit 60 analyzes the images stored in the storage unit 52 . Specifically, the image processing unit 60 extracts, for example, changes in images captured before and after a predetermined medical practice.
  • the display unit 54 displays images received from the camera 14, images analyzed by the image processing unit 60, and the like.
  • a speaker 56 generates an alarm sound or the like.
  • the blood vessel visualization system 12 is used, for example, to capture continuous or temporal changes in the same blood vessel 302 in the visualization target region 300 .
  • the blood vessel visualization system 12 compares the blood vessel images 400 of the target blood vessel 302 before and after the medical treatment, for example, and compares the effectiveness of the medical treatment (the efficacy of peripheral vasodilators, etc., the effect of exercise therapy, etc.). ) is used when evaluating the blood vessel visualization system 12 .
  • the blood vessel visualization member 10A when using the blood vessel visualization system 12, the blood vessel visualization member 10A is attached to the visualization target region 300 (the back of the hand in FIG. 1, etc.) before performing medical practice. That is, the adhesive surface 30 of the sheet body 22 is attached to the second surface 306 of the visualization target region 300 . At this time, since the sheet body 22 has flexibility, it deforms so as to follow the shape of the second surface 306 of the visualization target region 300 . In addition, by widening the cut portion 32 of the sheet body 22, formation of wrinkles on the outer peripheral portion of the sheet body 22 can be suppressed.
  • the power supply unit 42 is turned on while the first surface 304 of the visualization target region 300 is brought into contact (close contact) with each light source unit 36 of the irradiation unit 20 .
  • the near-infrared light L1 is emitted from the plurality of light source units 36 toward the first surface 304 of the visualization target region 300 .
  • the near-infrared light L1 passes through portions of the visualization target region 300 other than the blood vessel 302 . In other words, the near-infrared light L1 is absorbed by hemoglobin in the blood inside the blood vessel 302 of the visualization target region 300 .
  • Transmitted light that has passed through the visualization target region 300 in the near-infrared light L1 is converted into visible light L2 by the wavelength conversion material 28 of the wavelength conversion unit 24 . Therefore, a visible blood vessel image 400 is displayed on the wavelength conversion unit 24 (see FIG. 2B).
  • the blood vessel image 400 displayed on the wavelength conversion unit 24 is captured by the camera 14 .
  • Images (still images or moving images) captured by the camera 14 are transmitted to the information processing device 16 and stored in the storage unit 52 .
  • the image captured before the medical practice is performed may be referred to as the "first image".
  • the first image may not be stored in the storage section 52 of the information processing device 16, but may be stored in a storage section of another computer via the Internet.
  • the control unit 58 determines whether the blood vessel image 400 is normal based on the first image, and if it is abnormal (for example, if there is a possibility that blood flow is obstructed by stenosis) An alarm sound is generated from the speaker 56. - ⁇
  • the blood vessel image 400 displayed on the wavelength conversion unit 24 is captured by the camera 14 by the same method as described above.
  • the image of the blood vessel image 400 after the medical treatment taken by the camera 14 is transmitted to the information processing device 16 and stored in the storage unit 52 .
  • an image captured after a medical procedure is performed may be referred to as a "second image".
  • the second image may not be stored in the storage unit 52 of the information processing device 16, but may be stored in a storage unit of another computer via the Internet.
  • control unit 58 determines whether the blood vessel image 400 is normal based on the second image, and if it is abnormal (for example, if there is a possibility that blood flow is obstructed by stenosis) An alarm sound is generated from the speaker 56. - ⁇
  • the image processing unit 60 analyzes the first image and the second image, thereby extracting portions that change between the first image and the second image.
  • the control unit 58 causes the display unit 54 to display the analysis result of the image processing unit 60 . This allows users (including patients) to easily and accurately know the effects of medical practice.
  • the present embodiment has the following effects.
  • the sheet body 22 having the wavelength conversion section 24 is attached to the surface of the visualization target section 300, and the near-infrared light L1 transmitted through the visualization target section 300 is transformed into the visible light L2 by the wavelength conversion section 24. can be converted to Thereby, the visible blood vessel image 400 can be displayed on the wavelength conversion unit 24 . That is, the blood vessel visualization member 10A can display the blood vessel image 400 on the wavelength conversion section 24 positioned above the visualization target region 300 without using a member that converts the near-infrared light L1 into an image. Therefore, the blood vessel 302 can be visualized with a small and simple configuration.
  • the blood vessel visualization member 10A is attached to the second surface 306 of the visualization target region 300, the near-infrared light L1 transmitted through the visualization target region 300 can be efficiently received by the wavelength conversion unit 24. Therefore, the blood vessel image 400 can be displayed more clearly on the wavelength conversion unit 24 .
  • the wavelength converting portion 24 is formed in a sheet shape, and the bonding portion 26 is provided on the surface of the wavelength converting portion 24 facing the thickness direction.
  • the sheet body 22 has flexibility.
  • the sheet body 22 can be deformed according to the shape of the second surface 306 of the visualization target region 300 .
  • the sheet body 22 is provided with one or more notches 32 connected to the outer circumference of the sheet body 22 .
  • the sheet body 22 is configured to be permeable to liquid or gas in the thickness direction of the sheet body 22 .
  • the blood vessel visualization device 13A includes an irradiation section 20 including a light source section 36 for irradiating the second surface 306 of the visualization target region 300 with the near-infrared light L1.
  • the blood vessel image 400 can be displayed on the wavelength conversion section 24 by the blood vessel visualization device 13A.
  • the irradiation section 20 has an irradiation support section 38 that supports the light source section 36 so as to be displaceable.
  • the blood vessel visualization system 12 includes a camera 14 that captures the blood vessel image 400 displayed on the blood vessel visualization member 10A, and an image processing unit 60 that analyzes the image captured by the camera 14.
  • the blood vessel visualization system 12 can capture changes in the blood vessel image 400 of the wavelength conversion section 24 .
  • the blood vessel puncture system 100 includes a blood vessel visualization device 13B and a medical device 200. As shown in FIG. 4, the blood vessel puncture system 100 includes a blood vessel visualization device 13B and a medical device 200. As shown in FIG. 4, the blood vessel puncture system 100 includes a blood vessel visualization device 13B and a medical device 200. As shown in FIG.
  • the blood vessel visualization device 13B includes the blood vessel visualization member 10B and the above-described irradiation unit 20 (see FIG. 1).
  • the sheet body 22a of the blood vessel visualization member 10B further has a puncture hole 70 and a fragile portion 72 compared to the sheet body 22 of the blood vessel visualization member 10A described above.
  • the puncture hole 70 is a hole for puncturing the blood vessel 302 with the medical device 200 .
  • the puncture hole 70 is positioned so as to include a portion where the blood vessel 302 to be punctured (for example, the radial artery) is assumed to be located when the blood vessel visualization member 10B is adhered to the visualization target region 300.
  • the puncture hole 70 is located, for example, in the central portion of the sheet body 22a.
  • the puncture hole 70 is a circular hole.
  • the diameter of the puncture hole 70 is set to, for example, 1 mm or more and 10 mm or less.
  • the shape, position and size of the puncture hole 70 can be set as appropriate.
  • the fragile portion 72 extends from the outer circumference of the sheet body 22a to the puncture hole 70.
  • the fragile portion 72 has a shape that is easier to break than the portion other than the fragile portion 72 of the sheet body 22a.
  • the fragile portion 72 is, for example, a perforation.
  • the fragile portion 72 may be a groove that does not penetrate the sheet body 22a in the thickness direction. In this case, since the fragile portion 72 is thinner than the portion other than the fragile portion 72 of the sheet body 22a, it is easily broken (easily torn).
  • the weakened portion 72 has a first weakened line 74 and a second weakened line 76 .
  • the first line of weakness 74 extends linearly from the center of the first side 78 of the sheet body 22 a to the puncture hole 70 .
  • the cut portion 32 is not provided on the first side 78 .
  • the cut portion 32 may be provided on the first side 78 at a position avoiding the first line of weakness 74 .
  • the second line of weakness 76 extends linearly from the center of the second side 80 of the sheet body 22a to the puncture hole 70.
  • the puncture hole 70 is located between the first side 78 and the second side 80 of the sheet body 22a.
  • the second line of weakness 76 is located on an extension of the first line of weakness 74 .
  • the second side 80 is not provided with the notch 32 .
  • the second side 80 may be provided with the notch 32 at a position avoiding the second line of weakness 76 .
  • the medical device 200 is, for example, a catheter assembly 201.
  • Catheter assembly 201 has needle body 202 , needle hub 204 , catheter shaft 206 and catheter hub 208 .
  • Needle body 202 is configured to be able to puncture blood vessel 302 .
  • Needle hub 204 is provided at the proximal end of needle body 202 .
  • Catheter shaft 206 extends tubularly. In the initial state, the needle body 202 is inserted through the lumen of the catheter shaft 206 .
  • a catheter hub 208 is provided at the proximal end of the catheter shaft 206 .
  • the medical device 200 is not limited to the catheter assembly 201, and may be a puncture needle or the like for collecting blood.
  • the medical device 200 eg, the catheter hub 208 directly hits the second surface 306 of the visualization target region 300 when the medical device 200 punctures the blood vessel 302 or when the medical device 200 is left in the visualization target region 300. This can be prevented by the sheet body 22a.
  • the sheet body 22a may have a plurality of puncture holes 70.
  • the number and positions of puncture holes 70 can be set as appropriate.
  • the blood vessel puncture system 100 has the following effects.
  • the blood vessel 302 of the medical device 200 can be punctured by the medical device 200 (catheter assembly 201) while the blood vessel image 400 displayed on the wavelength conversion unit 24 is visually recognized. Puncture can be performed smoothly.
  • the wavelength conversion section 24 has a puncture hole 70 for puncturing the blood vessel 302 with the medical device 200 .
  • the medical device 200 can be punctured from the puncture hole 70 into the blood vessel 302 .
  • the puncture resistance can be reduced compared to the case where the medical device 200 penetrates the sheet body 22a.
  • the possibility of the sheet body 22a entering the visualization target region 300 as a foreign substance can be reduced.
  • the sheet body 22a has a fragile portion 72 extending from the outer circumference of the sheet body 22a to the puncture hole 70.
  • the fragile portion 72 can be broken and the sheet body 22a can be easily removed from the visualization target region 300.
  • the blood vessel puncture system 100 may include a blood vessel visualization member 10A instead of the blood vessel visualization member 10B. Further, the blood vessel puncture system 100 may include the camera 14 and the information processing device 16 described above.
  • the sheet bodies 22, 22a of the blood vessel visualization members 10A, 10B may be provided with adhesive portions 26a instead of the adhesive portions 26.
  • FIG. The adhesive portion 26 a is provided on the side surface of the wavelength conversion portion 24 .
  • the bonding portion 26 a surrounds the wavelength converting portion 24 .
  • the bonding portion 26a can be made of a material that does not transmit the near-infrared light L1.
  • the sheet members 22 and 22a may have an adhesive portion 26a in addition to the adhesive portion 26. As shown in FIG.
  • the sheet members 22, 22a of the blood vessel visualization members 10A, 10B may have a wavelength conversion section 24a instead of the wavelength conversion section 24.
  • the wavelength conversion section 24 a has a support layer 82 and a conversion section main body 84 .
  • the support layer 82 is formed into a sheet from a material that does not contain the wavelength conversion material 28 .
  • the support layer 82 has flexibility.
  • the support layer 82 is made of a resin material that can transmit the visible light L2.
  • the conversion section main body 84 is laminated on the support layer 82 .
  • the converter main body 84 is made of a material including the wavelength conversion material 28 .
  • the conversion body 84 is formed by coating the surface of the support layer 82 .
  • the bonding portion 26 is provided on the conversion portion main body 84 . That is, the conversion section main body 84 is located between the support layer 82 and the bonding section 26 .
  • the sheet bodies 22 and 22a may be provided with the adhesive portion 26a described above instead of the adhesive portion 26 on the side surface of the wavelength converting portion 24a, or may be provided with the adhesive portion 26a on the side surface of the wavelength converting portion 24a in addition to the adhesive portion 26. may
  • the wavelength conversion section 24a may be configured by exchanging the positions of the support layer 82 and the conversion section main body 84 shown in FIG. 5B.
  • the support layer 82 may be positioned between the conversion section main body 84 and the adhesive section 26 .
  • the sheet members 22, 22a of the blood vessel visualization members 10A, 10B may have a wavelength conversion section 24b instead of the wavelength conversion section 24.
  • the wavelength conversion section 24 b has a support layer 82 , a conversion section main body 84 and a reinforcement layer 86 .
  • the reinforcing layer 86 is constructed similarly to the support layer 82 .
  • the reinforcing layer 86 is laminated on the surface of the converting portion main body 84 opposite to the support layer 82 . That is, the conversion body 84 is positioned between the support layer 82 and the reinforcement layer 86 .
  • the reinforcing layer 86 can function as a cushion when the medical device 200 hits the sheet body 22a.
  • the wavelength converting portion 24b may be configured by exchanging the positions of the support layer 82 and the reinforcing layer 86.
  • the support layer 82 may be positioned between the conversion section main body 84 and the adhesive section 26 .

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PCT/JP2023/003491 2022-02-09 2023-02-03 血管可視化部材、血管可視化装置、血管穿刺システム及び血管可視化システム Ceased WO2023153320A1 (ja)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004237051A (ja) * 2003-02-06 2004-08-26 Ogawa Hiroteru 血管可視化方法ならびに装置
JP2008167792A (ja) * 2007-01-09 2008-07-24 Hitachi Maxell Ltd 生体情報取得デバイス
JP2015033585A (ja) * 2012-05-29 2015-02-19 国立大学法人高知大学 動脈可視化方法、動脈可視化装置、および動脈撮像装置
WO2016182075A1 (ja) * 2015-05-13 2016-11-17 株式会社プラス・メッド 動脈可視化装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160287814A1 (en) * 2015-04-06 2016-10-06 Jennus Innovation Corporation Medical illumination device
JP6700703B2 (ja) 2015-09-30 2020-05-27 コ−ケンメディカル株式会社 静脈可視化装置
WO2019232454A1 (en) * 2018-05-31 2019-12-05 Matt Mcgrath Design & Co, Llc Anatomical attachment device and associated method of use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004237051A (ja) * 2003-02-06 2004-08-26 Ogawa Hiroteru 血管可視化方法ならびに装置
JP2008167792A (ja) * 2007-01-09 2008-07-24 Hitachi Maxell Ltd 生体情報取得デバイス
JP2015033585A (ja) * 2012-05-29 2015-02-19 国立大学法人高知大学 動脈可視化方法、動脈可視化装置、および動脈撮像装置
WO2016182075A1 (ja) * 2015-05-13 2016-11-17 株式会社プラス・メッド 動脈可視化装置

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