WO2023147789A1 - Procédé de synthèse chimique d'oligosaccharide de chitosane à degré de polymérisation contrôlable - Google Patents

Procédé de synthèse chimique d'oligosaccharide de chitosane à degré de polymérisation contrôlable Download PDF

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Publication number
WO2023147789A1
WO2023147789A1 PCT/CN2023/079441 CN2023079441W WO2023147789A1 WO 2023147789 A1 WO2023147789 A1 WO 2023147789A1 CN 2023079441 W CN2023079441 W CN 2023079441W WO 2023147789 A1 WO2023147789 A1 WO 2023147789A1
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WO
WIPO (PCT)
Prior art keywords
chemical synthesis
synthesis method
self
glycosylation reaction
reaction
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PCT/CN2023/079441
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English (en)
Chinese (zh)
Inventor
尹健
成道泉
邹小鹏
王祥传
胡静
刘海玉
朋小军
王成
田光宗
王殿海
Original Assignee
山东京博农化科技股份有限公司
江南大学
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Application filed by 山东京博农化科技股份有限公司, 江南大学 filed Critical 山东京博农化科技股份有限公司
Publication of WO2023147789A1 publication Critical patent/WO2023147789A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

La présente invention divulgue un procédé de synthèse chimique d'oligosaccharide de chitosane ayant un degré de polymérisation contrôlable, qui se rapporte au domaine de la chimie du sucre. Le procédé selon la présente invention consiste : (1) à utiliser un bloc de construction de monosaccharide qui est relié à un groupe partant activable sur un carbone anomère et contient un hydroxyle exposé à C-4 en tant que substrat, de sorte que le bloc de construction de monosaccharide est utilisé à la fois en tant que donneur et récepteur ; à ajouter un accélérateur pour effectuer une réaction de glycosylation, de façon à générer des dérivés d'oligosaccharide de chitosane ayant différents degrés de polymérisation ; et à changer les groupes de protection du bloc de construction de saccharide et les conditions de réaction de glycosylation pour générer des dérivés d'oligosaccharide de chitosane entièrement protégés avec différents degrés de polymérisation ; et (2) à effectuer une déprotection pour obtenir des oligosaccharides de chitosane correspondants. Le procédé selon la présente invention présente les avantages suivants : un degré de polymérisation contrôlable, des étapes simples et pratiques et un taux de conversion élevé.
PCT/CN2023/079441 2022-03-15 2023-03-03 Procédé de synthèse chimique d'oligosaccharide de chitosane à degré de polymérisation contrôlable WO2023147789A1 (fr)

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CN202210252687.2A CN115215910A (zh) 2022-03-15 2022-03-15 一种聚合度可控的壳寡糖化学合成方法
CN202210252687.2 2022-03-15

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WO2023147789A1 true WO2023147789A1 (fr) 2023-08-10

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115215910A (zh) * 2022-03-15 2022-10-21 京博农化科技有限公司 一种聚合度可控的壳寡糖化学合成方法

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CN101421287A (zh) * 2006-04-07 2009-04-29 纳幕尔杜邦公司 脂壳寡糖的化学合成方法
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CN113004348A (zh) * 2021-03-26 2021-06-22 南京工业大学 一种机械自组装制备低聚糖的方法
CN113402569A (zh) * 2021-03-26 2021-09-17 南京工业大学 一种机械自组装制备低聚糖的方法
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