WO2023123421A1 - 一种长效抗菌消毒剂及制备方法和应用 - Google Patents
一种长效抗菌消毒剂及制备方法和应用 Download PDFInfo
- Publication number
- WO2023123421A1 WO2023123421A1 PCT/CN2021/143836 CN2021143836W WO2023123421A1 WO 2023123421 A1 WO2023123421 A1 WO 2023123421A1 CN 2021143836 W CN2021143836 W CN 2021143836W WO 2023123421 A1 WO2023123421 A1 WO 2023123421A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- long
- disinfectant
- acting antibacterial
- antibacterial disinfectant
- acting
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 58
- 239000000645 desinfectant Substances 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims description 16
- DBHODFSFBXJZNY-UHFFFAOYSA-N 2,4-dichlorobenzyl alcohol Chemical compound OCC1=CC=C(Cl)C=C1Cl DBHODFSFBXJZNY-UHFFFAOYSA-N 0.000 claims description 15
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 15
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 15
- 229960004698 dichlorobenzyl alcohol Drugs 0.000 claims description 15
- 238000004659 sterilization and disinfection Methods 0.000 claims description 15
- 239000004744 fabric Substances 0.000 claims description 14
- 239000004480 active ingredient Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- -1 polyethylene copolymer Polymers 0.000 claims description 8
- 239000004575 stone Substances 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 230000000149 penetrating effect Effects 0.000 claims description 6
- 229920000178 Acrylic resin Polymers 0.000 claims description 5
- 239000004925 Acrylic resin Substances 0.000 claims description 5
- 239000004593 Epoxy Substances 0.000 claims description 5
- 150000002191 fatty alcohols Chemical class 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 5
- JMGZBMRVDHKMKB-UHFFFAOYSA-L disodium;2-sulfobutanedioate Chemical compound [Na+].[Na+].OS(=O)(=O)C(C([O-])=O)CC([O-])=O JMGZBMRVDHKMKB-UHFFFAOYSA-L 0.000 claims description 4
- CBFCDTFDPHXCNY-UHFFFAOYSA-N octyldodecane Natural products CCCCCCCCCCCCCCCCCCCC CBFCDTFDPHXCNY-UHFFFAOYSA-N 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 3
- 239000011259 mixed solution Substances 0.000 claims description 2
- 230000035515 penetration Effects 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000373 fatty alcohol group Chemical group 0.000 claims 1
- 229920001558 organosilicon polymer Polymers 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 230000002147 killing effect Effects 0.000 abstract description 10
- 238000012360 testing method Methods 0.000 abstract description 6
- 239000000243 solution Substances 0.000 description 13
- 241000894006 Bacteria Species 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 5
- 239000000835 fiber Substances 0.000 description 5
- 125000005227 alkyl sulfonate group Chemical group 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 231100000344 non-irritating Toxicity 0.000 description 3
- 230000009972 noncorrosive effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- HWJHLQSSWFHRQU-UHFFFAOYSA-N 1,4-didecoxy-1,4-dioxobutane-2-sulfonic acid Chemical group CCCCCCCCCCOC(=O)CC(S(O)(=O)=O)C(=O)OCCCCCCCCCC HWJHLQSSWFHRQU-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- 229910000838 Al alloy Inorganic materials 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 229920002334 Spandex Polymers 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000004579 marble Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229920005573 silicon-containing polymer Polymers 0.000 description 2
- 239000004759 spandex Substances 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- ZDFDJKNMVBIUTI-UHFFFAOYSA-N 1-(2-bromopropan-2-yl)-2-dodecylbenzene Chemical compound CCCCCCCCCCCCC1=CC=CC=C1C(C)(C)Br ZDFDJKNMVBIUTI-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- ATVJXMYDOSMEPO-UHFFFAOYSA-N 3-prop-2-enoxyprop-1-ene Chemical compound C=CCOCC=C ATVJXMYDOSMEPO-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000295146 Gallionellaceae Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 240000006240 Linum usitatissimum Species 0.000 description 1
- 235000004431 Linum usitatissimum Nutrition 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 150000001335 aliphatic alkanes Chemical group 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 229940065181 bacillus anthracis Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- SYNISXGCUQLMQF-UHFFFAOYSA-L disodium;2,2-didecyl-3-sulfobutanedioate Chemical group [Na+].[Na+].CCCCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCCCC SYNISXGCUQLMQF-UHFFFAOYSA-L 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000013095 identification testing Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 208000024335 physical disease Diseases 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/04—Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
Definitions
- the invention belongs to the technical field of disinfectant compositions, and in particular relates to a long-acting antibacterial disinfectant that can form a protective film, is non-irritating, non-corrosive, safe and stable, and its preparation method and application.
- the indoor environment is the basic place for people to live, and most people spend more than 16 hours a day indoors. Although most of the time is spent indoors every day, it also needs frequent contact with the outside world, so it is easy to bring germs into the room, and indoor members are in the same space.
- the quality of the indoor environment directly affects the health of the entire family. It is conceivable that the cleaning and disinfection of the indoor environment is not only responsible for your own health, but also for the health of others.
- Cleaning objects include but are not limited to household items, such as indoor walls and floors that may carry various germs or viruses.
- Mycobacterium tuberculosis can survive for half a year in dry sputum; Bacillus anthracis and Bacillus tetanus can survive for several years after forming spores. These bacterial viruses cannot be removed by simple cleaning, and must be removed by disinfection.
- the disinfection of the indoor environment is mainly manifested in the following aspects:
- the object of the present invention is to provide a long-acting antibacterial disinfectant that can form a long-term protective film, non-irritating, non-corrosive, safe and stable, and can be applied to the surface of most materials; another object of the present invention is to provide the aforementioned antibacterial The preparation method of disinfectant; Another object of the present invention is to provide the application of aforementioned antibacterial disinfectant on any material surface of stone, floor, epoxy floor, body of wall, glass, metal, fabric to sterilize and bacteriostasis.
- One aspect of the present invention provides a long-acting antibacterial disinfectant, which comprises the following components in terms of mass percentage: 0.2-5% of disinfectant active ingredients, 1-15% of film-forming agent, 2-10% of penetrating agent, and the balance is solvent ; Wherein, the active ingredient includes any one of 2,4-dichlorobenzyl alcohol or cetylpyridinium chloride or a combination of both, and the pH of the antibacterial disinfectant is 6 ⁇ 0.5.
- the disinfectant active ingredient is a combination of 2,4-dichlorobenzyl alcohol and cetylpyridinium chloride.
- the inventors found that the use of 2,4-dichlorobenzyl alcohol and cetylpyridinium chloride as the active disinfectant components has a significant synergistic effect, which is significantly higher than the antibacterial and antibacterial effects of using any one of the disinfectant components alone. It is worth noting that the selection of the disinfectant active ingredients pays special attention to the corrosion and irritation of the fabric surface, and the selection of its components is very friendly to clothing and household items, and will not corrode or fade.
- the antibacterial disinfectant is non-irritating to the skin, can care for the user's skin while disinfecting; has no irritating smell, and has high safety in use.
- the film-forming agent used in the formula of the antibacterial disinfectant of the present invention is conducive to forming a protective film on the surface of objects, which greatly prolongs the antibacterial ability of the disinfectant active ingredients.
- the 2,4-dichlorobenzyl alcohol in the disinfectant active ingredient of the present invention has a wide range of microbial killing effects, and can fight against a variety of bacteria and fungi, including yeast, mold, especially common fungi on the skin surface, and some Gram-positive bacteria and Gram-negative bacteria.
- 2,4-Dichlorobenzyl Alcohol can be directly contacted with the skin without harm and side effects, and has good compatibility, and can be compatible with various surfactant series such as anionic, cationic, nonionic and amphoteric surfactants.
- Cetylpyridinium chloride has good surface activity and bactericidal and disinfecting properties, and is a cationic disinfectant.
- the killing rate of cetylpyridinium chloride on heterotrophic bacteria and iron bacteria is better than that of dodecyldimethylbenzyl ammonium chloride and dodecyldimethylbenzyl bromide Commonly used quaternary ammonium fungicides such as ammonium.
- the mass ratio of the 2,4-dichlorobenzyl alcohol to cetylpyridinium chloride is 0.5-3:1.
- the mass ratio of 2,4-dichlorobenzyl alcohol to cetylpyridinium chloride is 3:2.
- the film-forming agent described in the present invention is selected from any one or more combinations including but not limited to acrylic resin, polyethylene copolymer, silicone polymer or ethyl cellulose.
- the acrylic resin is a polymer formed by chemical crosslinking of acrylic acid or acrylate and allyl ether, and its molecular structure has a relatively high content of carboxyl groups and is hydrophilic.
- carbomer products which are currently widely used in thickening, suspension, and stabilization systems, such as Lubrizol’s Ultrez 10, Ultrez 20, Ultrez 21 and other products.
- Polyethylene copolymers are selected from including but not limited to polyvinyl alcohol polymers, such as polyvinyl alcohol PVA series products produced by Kuraray, Japan.
- Silicone polymers are selected from including, but not limited to, polydimethylsiloxanes.
- the film-forming agent is a mixture of silicone-modified acrylate and acrylic resin.
- the film-forming agent is formed by mixing silicone-modified acrylate and acrylate at a mass ratio of 2-4:1.
- the penetrating agent is selected from any one or a combination of, but not limited to, fatty alcohol polyoxyalkyl ether, sodium secondary alkyl sulfonate or didecyl sodium sulfosuccinate.
- the penetrating agent is formed by mixing fatty alcohol polyoxyalkyl ether, sodium secondary alkyl sulfonate, and didecyl sodium sulfosuccinate in a mass ratio of 2:1:2.
- the invention provides the preparation method of aforementioned long-acting antibacterial disinfectant comprising the following steps:
- Stone surfaces include floor tiles, floor tiles, household items with stone surfaces, etc., including natural stones such as marble, and artificially synthesized stones; floor surfaces are common wooden material surfaces in the market or wooden material surfaces with paint layers; walls
- the surface is the surface of wall materials such as calcium carbonate and talcum powder with a coating layer;
- the metal surface is mainly made of aluminum alloy, stainless steel and other materials;
- the fabric material is a common material for clothing in the textile industry, such as pure cotton, flax, fiber, chemical fiber, Spandex, acrylic, polyester, blended fabrics, etc.
- the above materials are widely used in the indoor environment of human living and home furnishing.
- the long-acting antibacterial disinfectant provided by the invention has excellent bactericidal and antibacterial ability.
- the disinfectant active ingredients of either or both of 2,4-dichlorobenzyl alcohol and cetylpyridinium chloride have a bactericidal rate of at least 99.99%, while 2,4-dichlorobenzyl alcohol is used
- the disinfectant active ingredients compatible with benzyl alcohol and cetylpyridinium chloride can achieve a bactericidal rate of more than 99.9999%.
- the logarithm of killing of the long-acting antibacterial disinfectant provided by the present invention is not less than 4 in 30 days, and the logarithm of killing in 90 days is not less than 2.5.
- the logarithm of killing on the 30th day after use is not less than 6
- the logarithm of killing on the 90th day after use is not less than 5.2.
- the long-acting antibacterial disinfectant provided by the invention has the following beneficial effects:
- the antibacterial rate is greater than 99.999% for surfaces of various materials (stone, floor, epoxy floor, wall, glass, metal, fabric) for 90 days; it can be used in a wide range of scenarios, such as clothes, pants, underwear, Disinfection of different fabrics such as towels, bed sheets, pillow covers, etc.; can be used for disinfection of hard surfaces made of different materials such as household, desktop, floor, kitchen, children's toys, etc.
- Present embodiment provides a kind of long-acting antibacterial disinfectant, comprises following component by mass percentage:
- 2,4-Dichlorobenzyl alcohol 1%
- Carbomer Ultrez 10 2%
- Present embodiment provides another kind of long-acting antibacterial disinfectant, comprises following component by mass percentage:
- 2,4-dichlorobenzyl alcohol and cetylpyridinium chloride are mixed in a mass ratio of 3:2, 0.5%;
- PVA217 and PVA1788 are mixed in a mass ratio of 3:1, 6%;
- Present embodiment provides another kind of long-acting antibacterial disinfectant, comprises following component by mass percentage:
- Cetylpyridinium chloride 1%; ethyl cellulose, 10%; penetrant made of sodium secondary alkyl sulfonate and sodium didecyl sulfosuccinate at a mass ratio of 2:3, 5%; the rest for water.
- Embodiment 1-3 simulates field disinfection test result to fabric surface
- Samples 1-10 are natural fiber fabrics, specifically 1-3 pure cotton cloth, 4-6 linen, and 7-10 are fibers; samples 11-20 are chemical fiber fabrics, specifically 11-13 spandex; 14 -16 acrylic; 17-20 is polyester; samples 21-30 are blended fabrics; the higher the log kill value, the better the bactericidal effect.
- Embodiment 1-3 simulates field disinfection test results to other object surfaces
- Samples 1-10 are the floors of offices, toilets, and experimental waste treatment rooms, specifically 1-3 floor tile surfaces, 4-6 are floor surfaces, and 7-10 are epoxy floor surfaces;
- Samples 11-20 are the walls of offices, toilets, and experimental waste disposal rooms, specifically 11-13 glass surfaces, 14-16 aluminum alloy surfaces, and 17-20 non-woven fabric surfaces;
- Samples 21-30 are desktops in offices, toilets, and experimental garbage disposal rooms, specifically 21-23 wood surface; 24-26 marble surface; 27-30 stainless steel surface.
- the long-acting antibacterial disinfectant of the present invention is effective against different object surfaces (fabrics such as towels, rags, clothing; hard surfaces such as offices, toilets, and experimental garbage disposal floors, desktops, walls, etc.)
- the antibacterial rate can be kept greater than 99.999% (logarithm of killing > 5) for 90 days.
- Example 2 Compared with Example 1 and Example 3, Example 2 has better effect, better antibacterial effect and more stable antibacterial performance.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Toxicology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
本发明公开了一种长效抗菌消毒剂及制备方法和应用，按质量百分比计包括0.2-5％的消毒活性成分，1-15％的成膜剂，2-10％的渗透剂，pH为6±0.5。该消毒剂对各种物体表面通过测试可持续90天保持抗菌率大于99.999％(杀灭对数＞5)，具有广泛的应用场景。
Description
本发明属于消毒剂组合物技术领域，尤其涉及一种可形成保护膜、无刺激、无腐蚀性、安全稳定的长效抗菌消毒剂及制备方法，应用。
室内环境是人们生活的基本场所，大多数人每天平均16小时以上的时间在室内度过。虽然每天大部分时间是在室内度过，但也需经常与外界频繁接触，因此很容易将病菌带入室内，而室内成员同处一个空间，室内环境的质量直接影响着整个家庭的健康。可想而知，室内环境的清洁消毒既是为自己的健康负责，更是为他人的健康着想。
室内环境消毒是健康保障不可或缺的重要工作。清洁对象包括但不限于家居用品，比如室内墙体和地面可能带有多种病菌或病毒。据研究证明：结核杆菌在干燥的痰中可以生存半年之久；炭疽杆菌、破伤风杆菌形成芽胞以后可以数年不死。这些细菌病毒并不是通过简单的清洁就能去除的，必须依靠消毒才可去除。
室内环境的消毒主要表现在以下几个方面：
(1)室内的各种污染源会随着时间不断增加，只有及时地通过室内消毒才能降低室内环境的污染度，而且能杜绝污染源对室内不断的散发污染物质，杜绝污染源在房间或室内进行挥发并对人员健康构成潜在危害。
(2)由于各种污染成分不断的增加还会引起各种细菌滋生，想要能避免细菌的不断滋生，就需要对室内各种金属器皿、墙体及家具表面进行消毒杀菌，才能避免各种有害物质肆意传播。
(3)室内长时间不进行消毒不但有异味，还会有各种菌体存在于空气中。人在深呼吸、说话、打喷嚏时，细菌、病菌会通过人的咽喉部位，接着以飞沫的形式漂浮在空气之中、落在家中的各个角落，如室内有人感染传染病人，其飞沫中携带的病菌更容易感染其他人员。
(4)对于易受群体如老人小孩来说有着极为严重的影响，而且若是身体抵抗能力不足，就会引起身体上的各种疾病，或者可能造成传染病的发生，特别是对呼吸道的影响以及对人体过敏性的反应。
由于现有消毒剂往往专注于单一材质表面的抗菌表现，且抑菌效果随着时间流逝下降显著。因此一种可适用于室内环境多种材质表面可持续抗菌的消毒剂是必不可少的。
发明内容
本发明的目的是为了提供一种可形成长效保护膜，无刺激、无腐蚀性、安全稳定，可应用于大多数材料表面的长效抗菌消毒剂；本发明还有一个目的是提供前述抗菌消毒剂的制备 方法；本发明还有一个目的是提供前述抗菌消毒剂在石材、地板、环氧地坪、墙体、玻璃、金属、织物任意一种材料表面上杀菌和抑菌的应用。
为了实现上述目的，本发明采用以下技术方案：
本发明一方面提供了一种长效抗菌消毒剂，按质量百分比计包括以下组分：消毒活性成分0.2-5％，成膜剂1-15％，渗透剂2-10％，余量为溶剂；其中，所述活性成分包括2,4-二氯苄醇或氯化十六烷基吡啶中的任意一种或两者的组合，该抗菌消毒剂的pH为6±0.5。
作为本发明的一种优选方案，所述消毒活性成分为2,4-二氯苄醇和氯化十六烷基吡啶的组合。发明人发现利用2,4-二氯苄醇和氯化十六烷基吡啶作为消毒活性成分具有显著的协同增效效果，比单独使用任意一种消毒成分的抗菌抑菌效果具有明显提高。值得注意的是，所述消毒活性成分的选用特别注重织物表面的腐蚀性和刺激性，其组分的选用对衣物、家居物品非常友好，不会出现腐蚀、褪色等现象。所述抗菌消毒剂对皮肤无刺激性，在消毒的同时可以呵护使用者的皮肤；无任何刺激性气味，使用安全性高。
另一方面，本发明抗菌消毒剂配方中采用成膜剂，有利于在物体表面形成一层保护膜，极大地延长了消毒活性成分的抑菌能力。
本发明消毒活性成分中的2,4-二氯苄醇具有广泛的微生物杀灭作用，可以对抗多种细菌和真菌，包括酵母菌、霉菌、特别是皮肤表面常见真菌，以及一些革兰氏阳性菌和革兰氏阴性菌。2,4-二氯苄醇可直接与皮肤接触而无危害，副作用，且具有配伍性好，能与各种表面活性剂系列如阴离子、阳离子、非离子和两性的表面活性剂相容。氯化十六烷基吡啶具有良好的表面活性和杀菌消毒性能，是一种阳离子类型消毒剂。在同等使用条件下，氯化十六烷基吡啶对异养菌和铁细菌杀灭率均优于十二烷基二甲基苄基氯化铵、十二烷基二甲基苄基溴化铵等常用的季铵盐杀菌剂。
进一步地，为了获得更好的抗菌抑菌效果，所述2,4-二氯苄醇和氯化十六烷基吡啶的质量比为0.5-3:1。作为本发明的最优方案，所述2,4-二氯苄醇和氯化十六烷基吡啶的质量比为3:2。
本发明所述的成膜剂选自包括但不限于丙烯酸树脂、聚乙烯共聚物、有机硅聚合物或乙基纤维素中的任意一种或多种的组合。
其中，所述丙烯酸树脂为丙烯酸或丙烯酸酯与烯丙基醚化学交联形成的聚合物，分子结构具有较高含量的羧基，具有亲水性。最常见的为卡波姆类产品，其目前被广泛用于增稠、悬浮、稳定体系等，例如美国路博润的
Ultrez 10、Ultrez 20、Ultrez 21等产品。聚乙烯类共聚物选自包括但不限于聚乙烯醇聚合物，例如日本可乐丽生产的聚乙烯醇PVA系列产品。有机硅聚合物选自包括但不限于聚二甲基硅氧烷。作为本发明的进一步优化，所述成 膜剂为有机硅改性丙烯酸酯和丙烯酸树脂的混合物。作为本发明的优选方案，所述成膜剂为有机硅改性丙烯酸酯和丙烯酸酯按质量比2-4:1混合而成。
进一步地，所述渗透剂选自包括但不限于脂肪醇聚氧烷基醚、仲烷基磺酸钠或磺基琥珀酸二癸酯钠中的任意一种或多种的组合。
作为本发明的进一步优化，所述的渗透剂为脂肪醇聚氧烷基醚、仲烷基磺酸钠、磺基琥珀酸二癸酯钠按质量比2:1:2混合而成。
本发明提供了前述长效抗菌消毒剂的制备方法包括以下步骤：
1)按配方量将消毒活性成分、成膜剂与渗透剂加入到溶剂中，混合均匀，得到混合液；
2)调节pH至6±0.5，混合均匀获得长效抗菌消毒剂。
前述技术方案所述的长效抗菌消毒剂同时具有对石材、地板、环氧地坪、墙体、玻璃、金属、织物材料表面优异的抗菌和抑菌效果。石材表面包括地砖、地板砖、具有石材表面的家居用品等，包括像大理石等天然石材、以及人工合成的石材；地板表面为市场上常见的木质材料表面或具有涂料层的木质材料表面；墙体表面为具有涂料层的碳酸钙、滑石粉等墙体材料的表面；金属表面主要为铝合金、不锈钢等材料；织物材料为纺织行业制衣的常用材料，例如纯棉、亚麻、纤维、化纤、氨纶、腈纶、涤纶、混纺面料等。上述材料广泛应用于人类生活家居的室内环境中。
根据卫生部出版的《消毒技术规范(2002年版本)》第2.1.2.9节公开的“消毒产品消毒效果检验技术规范”进行的微生物杀灭效果评价，本发明提供的长效抗菌消毒剂具有优秀的杀菌和抑菌能力。从杀菌效果上来看，选用2,4-二氯苄醇和氯化十六烷基吡啶的任意一种或两者的消毒活性成分，具有至少99.99％的杀菌率，而选用2,4-二氯苄醇和氯化十六烷基吡啶相配伍的消毒活性成分最高可实现99.9999％以上的杀菌率。从抑菌效果上来看，本发明提供的长效抗菌消毒剂30天的杀灭对数不低于4，90天的杀灭对数不低于2.5。但对于采用2,4-二氯苄醇和氯化十六烷基吡啶的组合，使用后第30天的杀灭对数不低于6，在使用后第90天的杀灭对数不低于5.2。
本发明提供的长效抗菌消毒剂与现有技术相比具有以下有益效果：
1)对各种材质表面(石材、地板、环氧地坪、墙体、玻璃、金属、织物)可持续90天保持抗菌率大于99.999％；使用场景广泛，可用于衣服、裤子、贴身衣物、毛巾、床单、枕巾等不同织物的消毒；可用于家居、桌面、地面、厨房、儿童玩具等不同材质的硬表面消毒
2)可在物体表面形成一层保护膜，延长了产品的抑菌效果；
3)产品配方无腐蚀性，对衣物、家居物品友好，不会产生腐蚀、褪色等现象；
4)不会对皮肤产生刺激；
5)无刺激性气味，使用方便，安全，适用于家庭，办公室，卫生间等室内使用。
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。须说明的是，本发明中所用原料，若未特指，均可从市场购得。
实施例1
本实施例提供了一种长效抗菌消毒剂，按质量百分比包括如下组分：
2,4-二氯苄醇，1％；卡波姆
Ultrez 10，2％；脂肪醇聚氧烷基醚、仲烷基磺酸钠、磺基琥珀酸二癸酯钠按质量比1:1:1制成的渗透剂，3％，其余为水。
将上述各组分混合均匀，再加入盐酸溶液或氢氧化钠溶液调节pH至6.5，混合均匀即可得到本品。
实施例2
本实施例提供了另一种长效抗菌消毒剂，按质量百分比包括如下组分：
2,4-二氯苄醇和氯化十六烷基吡啶按质量比3:2混合，0.5％；PVA217与PVA1788按质量比3:1混合，6％；脂肪醇聚氧烷基醚、仲烷基磺酸钠、磺基琥珀酸二癸酯钠按质量比2:1:2制成的渗透剂，6％，其余为水。
将上述各自分明混合均匀，再加入盐酸溶液或氢氧化钠溶液调节pH至6.5，混合均匀即可得到本品。
实施例3
本实施例提供了另一种长效抗菌消毒剂，按质量百分比包括如下组分：
氯化十六烷基吡啶，1％；乙基纤维素，10％；仲烷基磺酸钠、磺基琥珀酸二癸酯钠按质量比2:3制成的渗透剂，5％；其余为水。
将上述各组分混合均匀，再加入盐酸溶液或氢氧化钠溶液调节pH至6.5，混合均匀即可得到本品。
试验例
根据中华人民共和国卫生部出版的《消毒技术规范(2002年版本)》第2.1.2.9节公开的消毒剂对其它表面消毒模拟现场鉴定试验，以及《WS/T 650-2019抗菌和抑菌效果评价方法》第5.2.7节关于持续抗菌试验公开的试验方法，对实施例1-3制得的消毒剂进行试验，根据对照组菌数计算杀灭对数。
试验结果见表1与表2：
表1.实施例1-3对织物表面模拟现场消毒试验结果
表1备注：样本1-10为天然纤维面料，具体为1-3纯棉布，4-6亚麻，7-10为纤维；样本11-20为化学纤维面料，具体为11-13氨纶；14-16腈纶；17-20为涤纶；样本21-30为混纺面料；杀灭对数值越高表示杀菌效果越好。
表2.实施例1-3对其他物体表面模拟现场消毒试验结果
表2备注：样本1-10为办公室、卫生间、试验垃圾废物处理间的地面，具体为1-3地板砖表面，4-6为地板表面，7-10为环氧地坪表面；
样本11-20为办公室、卫生间、试验垃圾废物处理间的墙面，具体为11-13玻璃表面，14-16铝合金表面，17-20为无纺布表面；
样本21-30为办公室、卫生间、试验垃圾废物处理间的桌面，具体为21-23木材表面；24-26大理石表面；27-30不锈钢表面。
由表1与表2可见，本发明的长效抗菌的消毒剂，对不同物体表面(毛巾、抹布、衣物等织物；办公室、卫生间、试验垃圾废物处理间地面、桌面、墙面等硬表面)可持续90天保持抗菌率大于99.999％(杀灭对数＞5)。
相较于实施例1和实施例3，实施例2的效果更好，抗菌效果更好，抑菌性能更稳定。
以上所述，仅为本发明的较佳实施例，并非对本发明任何形式上和实质上的限制，应当指出，对于本技术领域的普通技术人员，在不脱离本发明方法的前提下，还将可以做出若干改进和补充，这些改进和补充也应视为本发明的保护范围。凡熟悉本专业的技术人员，在不脱离本发明的精神和范围的情况下，当可利用以上所揭示的技术内容而做出的些许更动、修饰与演变的等同变化，均为本发明的等效实施例；同时，凡依据本发明的实质技术对上述实施例所作的任何等同变化的更动、修饰与演变，均仍属于本发明的技术方案的范围内。
Claims (10)
- 一种长效抗菌消毒剂，其特征在于，按质量百分比计包括以下组分：消毒活性成分0.2-5％，成膜剂1-15％，渗透剂2-10％，余量为溶剂；其中，所述活性成分包括2,4-二氯苄醇或氯化十六烷基吡啶中的任意一种或两者的组合，该抗菌消毒剂的pH为6±0.5。
- 根据权利要求1所述的一种长效抗菌消毒剂，其特征在于，所述消毒活性成分为2,4-二氯苄醇和氯化十六烷基吡啶的组合。
- 根据权利要求2所述的一种长效抗菌消毒剂，其特征在于，所述2,4-二氯苄醇和氯化十六烷基吡啶的质量比为0.5-3:1。
- 根据权利要求2-3任意一项所述的一种长效抗菌消毒剂，其特征在于，所述成膜剂包括丙烯酸树脂、聚乙烯共聚物、有机硅聚合物或乙基纤维素中的任意一种或多种的组合。
- 根据权利要求4所述的一种长效抗菌消毒剂，其特征在于，所述成膜剂为有机硅改性丙烯酸酯和丙烯酸树脂按质量比2-4:1混合而成。
- 根据权利要求5所述的一种长效抗菌消毒剂，其特征在于，所述渗透剂包括脂肪醇聚氧烷基醚、仲烷基磺酸钠或磺基琥珀酸二癸酯钠中的任意一种或多种的组合。
- 根据权利要求6所述的一种长效抗菌消毒剂，其特征在于，所述的渗透剂为脂肪醇聚氧烷基醚、仲烷基磺酸钠、磺基琥珀酸二癸酯钠按质量比2:1:2混合而成。
- 如权利要求1-7任意一项所述的长效抗菌消毒剂的制备方法，其特征在于包括以下步骤：1)按配方量将消毒活性成分、成膜剂与渗透剂加入到溶剂中，混合均匀，得到混合液；2)调节pH至6±0.5，混合均匀获得长效抗菌消毒剂。
- 如权利要求2-7任意一项所述的长效抗菌消毒剂在石材、地板、环氧地坪、墙体、玻璃、金属、织物材料表面上杀菌和抑菌的应用。
- 根据权利要求9所述的应用，其特征在于：所述长效抗菌消毒剂在使用后第30天的杀灭对数不小于6，在使用后第90天的杀灭对数不低于5.2。
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2021/143836 WO2023123421A1 (zh) | 2021-12-31 | 2021-12-31 | 一种长效抗菌消毒剂及制备方法和应用 |
| CN202180055014.1A CN117082977A (zh) | 2021-12-31 | 2021-12-31 | 一种长效抗菌消毒剂及制备方法和应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2021/143836 WO2023123421A1 (zh) | 2021-12-31 | 2021-12-31 | 一种长效抗菌消毒剂及制备方法和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2023123421A1 true WO2023123421A1 (zh) | 2023-07-06 |
Family
ID=86997121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2021/143836 WO2023123421A1 (zh) | 2021-12-31 | 2021-12-31 | 一种长效抗菌消毒剂及制备方法和应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN117082977A (zh) |
| WO (1) | WO2023123421A1 (zh) |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4167583A (en) * | 1973-07-03 | 1979-09-11 | Bayer Aktiengesellschaft | Microbial composition and formulations |
| JPH07324005A (ja) * | 1994-05-31 | 1995-12-12 | Tomey Technol Corp | 消毒剤組成物及びそれを用いた消毒方法 |
| US20070280901A1 (en) * | 2006-06-02 | 2007-12-06 | The Dial Corporation | Method of inhibiting the transmission of influenza virus |
| CN101854927A (zh) * | 2007-11-15 | 2010-10-06 | 雷克特本克斯尔保健(英国)有限公司 | 具有麻醉效果的抗菌化合物的应用 |
| JP2012167029A (ja) * | 2011-02-10 | 2012-09-06 | Kao Corp | 抗住環境真菌剤 |
| CN103002732A (zh) * | 2010-07-14 | 2013-03-27 | 花王株式会社 | 抗菌剂 |
| WO2013158165A1 (en) * | 2012-04-17 | 2013-10-24 | Oasis Consumer Healthcare, Llc. | Long-lasting surface anti-microbial and method of application |
| US20140051732A1 (en) * | 2011-04-19 | 2014-02-20 | Arm Pharmaceutical Llc | Low-tack surface anti-microbial coating composition and method of application |
| CN103719142A (zh) * | 2012-10-10 | 2014-04-16 | 俞致健 | 一种消毒剂及其制备方法与应用 |
| CN103860526A (zh) * | 2013-11-26 | 2014-06-18 | 华熙福瑞达生物医药有限公司 | 一种含透明质酸的消毒剂、其制备方法及用途 |
| CN107494618A (zh) * | 2017-09-05 | 2017-12-22 | 无锡智谷锐拓技术服务有限公司 | 一种医用高效消毒剂及其制备方法 |
| CN111249176A (zh) * | 2020-02-21 | 2020-06-09 | 华熙生物科技股份有限公司 | 免洗消毒剂、制备方法及其应用 |
| CN113712028A (zh) * | 2020-10-21 | 2021-11-30 | 南京百思福医药科技有限公司 | 一种光致发光长效成膜消毒组合物及其制备方法与应用 |
-
2021
- 2021-12-31 WO PCT/CN2021/143836 patent/WO2023123421A1/zh active Application Filing
- 2021-12-31 CN CN202180055014.1A patent/CN117082977A/zh active Pending
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4167583A (en) * | 1973-07-03 | 1979-09-11 | Bayer Aktiengesellschaft | Microbial composition and formulations |
| JPH07324005A (ja) * | 1994-05-31 | 1995-12-12 | Tomey Technol Corp | 消毒剤組成物及びそれを用いた消毒方法 |
| US20070280901A1 (en) * | 2006-06-02 | 2007-12-06 | The Dial Corporation | Method of inhibiting the transmission of influenza virus |
| CN101854927A (zh) * | 2007-11-15 | 2010-10-06 | 雷克特本克斯尔保健(英国)有限公司 | 具有麻醉效果的抗菌化合物的应用 |
| CN103002732A (zh) * | 2010-07-14 | 2013-03-27 | 花王株式会社 | 抗菌剂 |
| JP2012167029A (ja) * | 2011-02-10 | 2012-09-06 | Kao Corp | 抗住環境真菌剤 |
| US20140051732A1 (en) * | 2011-04-19 | 2014-02-20 | Arm Pharmaceutical Llc | Low-tack surface anti-microbial coating composition and method of application |
| WO2013158165A1 (en) * | 2012-04-17 | 2013-10-24 | Oasis Consumer Healthcare, Llc. | Long-lasting surface anti-microbial and method of application |
| CN103719142A (zh) * | 2012-10-10 | 2014-04-16 | 俞致健 | 一种消毒剂及其制备方法与应用 |
| CN103860526A (zh) * | 2013-11-26 | 2014-06-18 | 华熙福瑞达生物医药有限公司 | 一种含透明质酸的消毒剂、其制备方法及用途 |
| CN107494618A (zh) * | 2017-09-05 | 2017-12-22 | 无锡智谷锐拓技术服务有限公司 | 一种医用高效消毒剂及其制备方法 |
| CN111249176A (zh) * | 2020-02-21 | 2020-06-09 | 华熙生物科技股份有限公司 | 免洗消毒剂、制备方法及其应用 |
| CN113712028A (zh) * | 2020-10-21 | 2021-11-30 | 南京百思福医药科技有限公司 | 一种光致发光长效成膜消毒组合物及其制备方法与应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN117082977A (zh) | 2023-11-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10448643B2 (en) | Low pH disinfectant composition | |
| CN101232807B (zh) | 具有高抗病毒和抗菌效力的组合物 | |
| US10350219B2 (en) | Antimicrobial compositions and methods of making the same | |
| US20080254080A1 (en) | Novel Uses of Calcium Hydroxide | |
| US20070280900A1 (en) | Compositions having a high antiviral efficacy | |
| BRPI1009652B1 (pt) | processo para preparar um artigo antimicrobiano e artigo antimicrobiano | |
| TW201141971A (en) | Surface multifunctional treatment agent composition | |
| CN104666285B (zh) | 薁磺酸钠抗过敏免洗快干净手剂 | |
| WO2011089839A1 (ja) | 表面多機能処理剤組成物 | |
| TW201111457A (en) | Novel article | |
| WO2023123421A1 (zh) | 一种长效抗菌消毒剂及制备方法和应用 | |
| CN1142264C (zh) | 一种完全可水溶解性洗手膜 | |
| CN101460053A (zh) | 具有高抗病毒和抗菌效果的方法和物品 | |
| ZA200704110B (en) | Novel uses of calcium hydroxide | |
| JPH072615A (ja) | 抗菌性消毒剤含浸布 | |
| JPH0193506A (ja) | 殺菌及び柔軟剤組成物 | |
| CN101453888A (zh) | 具有高抗病毒功效组合物 | |
| JPH07197085A (ja) | 洗浄剤 | |
| Bashckirtseva et al. | APPLICATION CHARACTERISTICS OF SILVER NANOPARTICLES AS DISINFECTIVE MEANS | |
| TR2021001953A2 (tr) | Yüzey dezenfektani | |
| JPH0739325B2 (ja) | 住居用防カビ剤 | |
| CN110352992A (zh) | 一种基于quat12除菌因子的复方消毒剂 | |
| JPH06256104A (ja) | 抗菌性持続型消毒剤 | |
| KR20090049926A (ko) | 경질표면용 살균제 조성물 및 이를 포함하는 살균용품 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WWE | Wipo information: entry into national phase |
Ref document number: 202180055014.1 Country of ref document: CN |
|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 21969767 Country of ref document: EP Kind code of ref document: A1 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |