WO2023116548A1 - 微针阵列芯片 - Google Patents

微针阵列芯片 Download PDF

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Publication number
WO2023116548A1
WO2023116548A1 PCT/CN2022/139300 CN2022139300W WO2023116548A1 WO 2023116548 A1 WO2023116548 A1 WO 2023116548A1 CN 2022139300 W CN2022139300 W CN 2022139300W WO 2023116548 A1 WO2023116548 A1 WO 2023116548A1
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WO
WIPO (PCT)
Prior art keywords
microneedle
microneedles
array chip
groove
cluster
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PCT/CN2022/139300
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English (en)
French (fr)
Inventor
徐百
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苏州纳生微电子有限公司
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Publication of WO2023116548A1 publication Critical patent/WO2023116548A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Definitions

  • the invention belongs to the technical field of transdermal drug delivery, and in particular relates to a microneedle array chip.
  • the microneedle array chip is a device that uses microneedles to penetrate the stratum corneum of the skin. It can be used in the medical or cosmetic fields, allowing medicines or beauty products to pass through the stratum corneum of the skin to achieve better absorption.
  • a large amount of prior art has recorded technical information such as preparation, material, structure, use and development of microneedle, such as CN100355470C, CN100402107C, CN103079634B, CN100408126C, CN100528091C, CN109432585A, CN111300702A, CN10558197 5A and many other patent documents.
  • microneedles there are two types of microneedles in traditional microneedle array chips: solid microneedles and hollow microneedles.
  • the reciprocating puncture of the solid microneedle can leave a micro channel on the stratum corneum, which can last for a short period of time. Channels through the stratum corneum of the skin, allowing it to be absorbed by the deeper tissues of the skin. However, the absorption efficiency of this method is low.
  • the working principle of the hollow microneedle is similar to that of a syringe.
  • the hollow microneedle penetrates into the stratum corneum of the skin and stays in the stratum corneum of the skin.
  • the injection system injects the medicine through the cavity of the hollow microneedle into the deep tissue of the skin.
  • the manufacturing process of hollow microneedles is complicated, the yield is low, and the production cost is high.
  • Soluble microneedles are made of organic materials, medicines or beauty products are solidified on the surface of the microneedles, and the soluble microneedles pass through the stratum corneum and stay in the stratum corneum of the skin for several minutes to several hours. Or cosmetic products are continuously dissolved in the deep tissues of the skin.
  • the manufacturing process of soluble microneedles is complex and costly.
  • the technical problem to be solved by the present invention is to provide a solid microneedle array chip that can improve the efficiency of medicaments or beauty products passing through the stratum corneum of the skin.
  • a microneedle array chip comprising a substrate and a plurality of microneedles arranged in an array on the front of the substrate, grooves are opened downward from the tips of the microneedles, the width of the grooves is not less than 10nm, and the depth is not less than 50nm.
  • microneedle a microneedle whose pointer length is less than 5mm
  • the material of the microneedle can be single crystal silicon, metal or organic material
  • the size of the microneedle can be micron or nanometer.
  • a drug reservoir is provided on the back of the substrate, and a fluid connection between the drug reservoir and the groove is realized through a through hole.
  • it also includes a through hole extending from the bottom surface of the groove to the back surface of the substrate.
  • the groove is a straight groove or is composed of two straight grooves intersecting at any angle.
  • a microneedle array chip comprising a substrate, the front of the substrate is provided with a plurality of microneedle clusters arranged in an array, each microneedle cluster is composed of at least two microneedles, and the microneedle clusters in each microneedle cluster
  • the gap between the needles is not less than 10 nm and not more than 300 ⁇ m.
  • microneedle cluster refers to a group of microneedles, and the number of microneedles in a microneedle cluster is not less than 2.
  • the spacing between the microneedles in the microneedle cluster is smaller than the spacing between the microneedle clusters on the microneedle array chip.
  • a drug storage pool is provided on the back of the substrate, and the bottom surface of the drug storage pool and the front surface of the substrate are fluidly connected through through holes, and the through holes are located between the microneedles in the microneedle cluster.
  • each microneedle cluster consists of two microneedles.
  • each microneedle cluster is composed of more than two microneedles, and the microneedles are arranged in a circle.
  • the beneficial effects of the present invention are: using the slots on the microneedles or the gaps between the microneedles in the microneedle clusters, the microneedles can be used to carry medicines or beauty products, and the microneedles can carry medicines or beauty products when they pass through the stratum corneum. Or cosmetic products are carried into the deep tissue below the stratum corneum of the skin, thereby improving the absorption efficiency of pharmaceuticals or cosmetic products.
  • Fig. 1 is the front schematic diagram of the microneedle chip array of embodiment 1;
  • Fig. 2 is a schematic diagram of the back of the microneedle chip array of Embodiment 1;
  • Fig. 3 is the local schematic diagram of the single microneedle cluster of embodiment one;
  • Fig. 4 is a partial schematic diagram of a single drug storage pool in Embodiment 1;
  • Figure 5 is a sectional view of a single microneedle cluster in Embodiment 1;
  • Fig. 6 is the local schematic diagram of the single microneedle cluster of embodiment two;
  • Fig. 7 is the local schematic diagram of the single microneedle cluster of embodiment three;
  • Fig. 8 is a partial side schematic view 1 of a single microneedle cluster in Example 3.
  • Fig. 9 is a partial side schematic diagram II of a single microneedle cluster in embodiment three;
  • Fig. 10 is a partial schematic diagram of a single microneedle cluster of embodiment four;
  • Figure 11 is a partial side view of a single microneedle cluster in Example 4.
  • Fig. 12 is a partial schematic view of a single microneedle cluster in Example five;
  • Fig. 13 is a cross-sectional view of a single microneedle cluster in Example 5.
  • the microneedle array chip is shown in FIG. 1 , a plurality of microneedle clusters 2 are arranged on the front of the substrate 1 , and the microneedle clusters 2 are arranged in a rectangular array, and the horizontal and vertical distances between the multiple microneedle clusters 2 are all 400 microns.
  • the structure of the microneedle cluster 2 is shown in Figure 3.
  • four microneedles 21 are surrounded together and arranged in a circular array or centrally symmetrically.
  • a cross-shaped channel is formed between the microneedles 21.
  • the channel can also be regarded as being composed of two mutually perpendicular rectangular channels intersecting.
  • each microneedle 21 is a quadrangular pyramid with a height of 300 micrometers, and the root section of the microneedles 21 is a square with a side length of 25 micrometers.
  • the distance between two adjacent microneedles 21 is 50 micrometers.
  • the cross-shaped channel is composed of two mutually perpendicular rectangular channels with a width of 50 micrometers.
  • the back side of the substrate 1 is provided with a drug storage pool 3, and the drug storage pool 3 is connected to the front of the substrate through a liquid guide hole, and the liquid guide hole makes the front of the substrate and the drug storage pool fluidly communicated, and the diameter of the liquid guide hole is 40 microns.
  • the liquid holes are located in the gaps between the microneedles 21 in the microneedle cluster 2 , that is, in the cross-shaped channel.
  • the solid microneedles in the prior art are replaced by the microneedle cluster 2, and the working principle of the microneedle cluster 2 penetrating the skin and
  • the solid microneedles are the same and are used to penetrate the stratum corneum of the skin. It is preferable to generate high-frequency vibrations through the penetration enhancer and other equipment to penetrate the stratum corneum and leave micropores in the stratum corneum. It can be used for cosmetic active ingredients or for treatment.
  • the medicinal ingredients can pass through the stratum corneum of the skin through the micropores and enter the deep structure of the skin, thereby improving the absorption effect of the active ingredients that can be used for beauty or the medicinal ingredients used for treatment.
  • this embodiment has also made the following technical progress: the gap between the microneedles 21 in the microneedle cluster 2 can play a certain carrying effect, and in the process of the microneedle cluster 2 reciprocatingly piercing the skin, This gap can carry active ingredients that can be used for cosmetics or medicinal ingredients for treatment into the deep structure of the skin, but the solid microneedles in the prior art do not have this carrying capacity. Therefore, compared with the existing The solid microneedle array chip in the technology can further improve the absorption effect of active ingredients that can be used for beauty or medicinal ingredients for treatment.
  • this embodiment also adds a drug storage pool 3 on the back of the substrate 1, as shown in Figures 2, 4 and 5, the drug storage pool 3 can store a certain amount of The active ingredients for beauty or the medicinal ingredients for treatment can be used for the active ingredients for beauty or the medicinal ingredients for treatment to reach the front of the substrate 1 and between the channels of the microneedle clusters 2 through the liquid guide holes, and to In the process of piercing the stratum corneum, the needle cluster 2 then passes through the stratum corneum and enters the deep structure of the skin, thus realizing the integrated design of the liquid and the machine, and there is no need to pre-apply the active ingredients that can be used for beauty before using the microneedle array chip.
  • the mechanism of the active ingredients that can be used for beauty or the medicinal ingredients used for treatment through the liquid guide hole is similar to the mechanism of the liquid coming out of the liquid outlet in equipment such as a liquid-machine-integrated penetration enhancer or a water-light gun, which can be used for beauty
  • the active ingredient or medicinal ingredient used for treatment is thrown out from the liquid guide hole due to its own inertia during the reciprocating vibration of the microneedle array chip.
  • Each microneedle cluster 2 is provided with a corresponding drug storage pool 3, and the drug storage pools 3 are connected by shallow grooves 4, so that the air pressure in each drug storage pool 3 can be the same, so that the liquid outlet of each microneedle cluster 2 The effect is consistent.
  • a plurality of microneedle clusters 2 are arranged on the front of the substrate 1, and the microneedle clusters 2 are arranged in a rectangular array, and the horizontal and vertical distances between the microneedle clusters 2 are all 300 microns.
  • the structure of the microneedle cluster 2 is shown in FIG. 6 .
  • the microneedle cluster 2 is composed of two microneedles 21 , both of which are in the shape of blades.
  • the height of the two microneedles is 300 microns, and the distance between the two microneedles is 50 microns.
  • one microneedle cluster 2 is composed of two microneedles 21, and the shape of microneedles 21 is blade-like, which can also be called a microblade.
  • the gap between the two microneedles 21 can also have a certain carrying effect.
  • it can further improve the active ingredients that can be used for beauty or for treatment. Absorption of medicinal ingredients.
  • a plurality of microneedles 21 are arranged on the front of the substrate 1, and the microneedles 21 are arranged in a rectangular array, and the horizontal and vertical distances between the microneedles 21 are all 300 microns.
  • the structure of the microneedle 21 is shown in Figures 7, 8 and 9.
  • the lower part of the microneedle body is a prism, and the upper part is formed with two triangular pointed parts 22.
  • a V-shaped groove 23 is formed between the two pointed parts 22, and the groove is deep. 100 microns, microneedle height 400 microns. As shown in FIGS. 7 , 8 and 9 , the depth of the groove 23 is smaller than the height of the microneedle 21 .
  • a groove structure is formed at the tip of the microneedle 22, and the principle of the microneedle 21 penetrating the skin is the same as that of the solid microneedle, for penetrating the keratin of the skin It is preferable to generate high-frequency vibration through the penetration enhancer and other equipment to penetrate the stratum corneum and leave micropores in the stratum corneum, and the active ingredients that can be used for beauty or the medicinal ingredients for treatment can pass through the skin through the micropores The stratum corneum, penetrates into the deep structure of the skin, thus enhancing the absorption of active ingredients that can be used for cosmetic purposes or medicinal ingredients for therapeutic purposes.
  • the groove 23 of the microneedle tip 22 can play a certain carrying effect, and the groove 23 can be carried and used in the process of the microneedle piercing the skin back and forth.
  • the active ingredient for beauty treatment or the medicinal ingredient for treatment enters the deep structure of the skin, but the solid microneedle in the prior art does not have this carrying capacity. Therefore, compared with the solid microneedle in the prior art, this embodiment
  • the array chip can further improve the absorption effect of active ingredients that can be used for beauty or medicinal ingredients for treatment.
  • the structure of microneedle tip 22 slotted in this embodiment adopts less structural changes to the existing solid microneedle, less technological change content, and is easy to apply.
  • the damage to the physical properties of the body is relatively small, and the advantages of the existing solid microneedle preparation process and the manufactured solid microneedle can be retained, such as the microneedle is not easy to break. It is easy to understand that when the depth of the groove 23 opened downward from the microneedle tip 22 is equal to the height of the microneedle, the microneedle can form a microneedle cluster structure without increasing the difficulty of the manufacturing process.
  • a plurality of microneedles 21 are arranged on the front of the substrate 1, and the microneedles 21 are arranged in a rectangular array, and the horizontal and vertical distances between the microneedles 21 are all 400 microns.
  • the microneedle structure is shown in Figures 10 and 11.
  • the front of the substrate 1 is provided with a microneedle 21 whose outer contour is an octagonal prism.
  • the top of the microneedle 21 is provided with a rectangular groove 23 from top to bottom, and the width of the groove 23 is 15mm.
  • the depth of the groove 23 is 100 microns
  • the height of the microneedle is 300 microns
  • the diameter of the bottom of the microneedle is 100 microns
  • the depth of the groove 23 is less than the height of the microneedle.
  • the microneedles in the fourth embodiment form a microneedle cluster structure similar to that in the second embodiment. That is, the microneedle cluster 2 in the second embodiment can be understood as a special case of the fourth embodiment.
  • the microneedle cluster in Example 1 can be understood as two straight grooves crossing and opening downward from the tip of the microneedle to a height equal to that of the microneedle.
  • a plurality of microneedles 21 are arranged on the front of the substrate 1, and the microneedles 21 are arranged in a rectangular array, and the horizontal and vertical distances between the microneedles 21 are all 300 microns.
  • the microneedle structure is shown in Figures 12 and 13.
  • the lower part of the microneedle 21 needle body is a prism, and the upper part is formed with two triangular sharp parts 22.
  • a groove 23 is formed between the two sharp parts.
  • the two sides of the groove 23 are inclined planes. , the width of the bottom of the groove 23 is 40 microns, the depth of the groove 23 is 100 microns, the height of the microneedle is 400 microns, and the depth of the groove 23 is less than the height of the microneedle 21.
  • a through hole 5 is formed from the back of the substrate 1 to the bottom of the groove 23, so that the microneedle 21 becomes a hollow microneedle.
  • a plurality of microneedle clusters 2 are arranged on the front of the substrate, the microneedle clusters 2 are arranged in a rectangular array, and the horizontal and vertical distances between the microneedle clusters 2 are all 300 microns.
  • the microneedle cluster 2 is composed of two microneedles 21, both of which are blade-shaped. The height of the two microneedles 21 is 300 microns, and the distance between the two microneedles is 10 nanometers.
  • a plurality of microneedle clusters 2 are arranged on the front of the substrate, and the microneedle clusters 2 are arranged in a rectangular array, and the horizontal and vertical distances between the microneedle clusters 2 are all 1000 microns.
  • the microneedle cluster 2 is composed of two microneedles 21, both of which are blade-shaped. The height of the two microneedles 21 is 500 microns, and the distance between the two microneedles 21 is 300 microns.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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Abstract

本发明公开了一种微针阵列芯片，包括基片和在基片正面呈阵列状排列的多个微针，由微针尖端向下开设有槽，槽的宽度不小于10nm，深度不小于50nm。一种微针阵列芯片，包括基片，所述基片正面设有呈阵列妆排列的多个微针簇，每个微针簇由至少两个微针组成，每个微针簇中的微针之间的间隙不小于10nm且不大于300μm。利用微针上的槽或微针簇中微针间的间隙，可以使微针起到携带药剂或美容产品的作用，微针在穿过角质层时即可将药剂或美容产品携带进入皮肤角质层下方的深层组织内，从而提高药剂或美容产品的吸收效率。

Description

微针阵列芯片 技术领域
本发明属于透皮给药技术领域，具体涉及一种微针阵列芯片。
 背景技术
微针阵列芯片是采用微针穿过皮肤角质层的装置，可用于医疗或美容领域，可以使药剂或美容产品穿过皮肤角质层，达到更好的吸收效果。该技术领域中已经有大量的现有技术记载了微针的制备、材料、结构、用途及发展等技术信息，比如CN100355470C、CN100402107C、CN103079634B、CN100408126C、CN100528091C、CN109432585A、CN111300702A、CN105581975A等诸多专利文献。
传统微针阵列芯片中的微针形态分为两种，分别是实心微针和空心微针。
实心微针通过往复的穿刺可以在角质层上留下微型通道，该通道可持续一小段时间，在该持续时间内，将药剂或美容产品施加到皮肤上，药剂或美容产品即可通过该微型通道穿过皮肤角质层，从而被皮肤的深层组织吸收。但是这种方式的吸收效率较低。
空心微针的作用原理类似于注射器，空心微针刺入皮肤角质层后停留在皮肤角质层内，由注射系统将药剂通过空心微针的空腔注射进皮肤的深层组织内。但是空心微针的制作工艺复杂、成品率低，并且生产成本高昂。
可溶微针由有机材料制成，药剂或美容产品固化于微针表面，可溶微针穿过角质层后停留在皮肤角质层内，持续数分钟至数小时，在该持续时间内，药剂或美容产品持续溶解在皮肤的深层组织内。但是可溶微针的制作工艺复杂、成本高。
因此，微针透皮给药技术领域的现有技术存在改进之处。
 技术问题
本发明要解决的技术问题是，提供一种可以提高药剂或美容产品穿过皮肤角质层的效率的实心微针阵列芯片。
 技术解决方案
为了解决上述技术问题，本发明采用的技术方案为：
一种微针阵列芯片，包括基片和在基片正面呈阵列状排列的多个微针，由微针尖端向下开设有槽，槽的宽度不小于10nm，深度不小于50nm。
定义：微针，指针长小于5mm的微型针，微针的材质可以采用单晶硅、金属或有机材料，微针的尺寸可以是微米级或纳米级。
优选的，所述基片背面设有储药池，所述储药池和所述槽之间通过通孔实现流体连接。
优选的，还包括从所述槽底面延伸至基片背面的通孔。
优选的，所述槽为一条直槽或由两条直槽以任意角度交叉组成。
一种微针阵列芯片，包括基片，所述基片正面设有呈阵列妆排列的多个微针簇，每个微针簇由至少两个微针组成，每个微针簇中的微针之间的间隙不小于10nm且不大于300μm。
定义：微针簇，指一组微针，一个微针簇内的微针数量不少于2个。微针簇内微针之间的间距小于微针阵列芯片上微针簇之间的间距。
优选的，基片背面设有储药池，所述储药池底面和所述基片正面之间通过通孔实现流体连接，所述通孔位于微针簇中微针之间的位置。
优选的，每个微针簇由两个微针组成。
优选的，每个微针簇由两个以上的微针组成，且微针呈圆周排列。
 有益效果
本发明的有益效果为：利用微针上的槽或微针簇中微针间的间隙，可以使微针起到携带药剂或美容产品的作用，微针在穿过角质层时即可将药剂或美容产品携带进入皮肤角质层下方的深层组织内，从而提高药剂或美容产品的吸收效率。
 附图说明
图1为实施例一的微针芯片阵列正面示意图；
图2为实施例一的微针芯片阵列背面示意图；
图3为实施例一的单个微针簇的局部示意图；
图4为实施例一的单个储药池的局部示意图；
图5为实施例一的单个微针簇处的剖示图；
图6为实施例二的单个微针簇的局部示意图；
图7为实施例三的单个微针簇的局部示意图；
图8为实施例三的单个微针簇的局部侧面示意图一；
图9为实施例三的单个微针簇的局部侧面示意图二；
图10为实施例四的单个微针簇的局部示意图；
图11为实施例四的单个微针簇的局部侧面示意图；
图12为实施例五的单个微针簇的局部示意图；
图13为实施例五的单个微针簇处的剖视图。
附图标记列表
1、基片；2、微针簇；21、微针；22、尖部；23、槽；3、储药池；4、浅槽；5、通孔。
 本发明的最佳实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。
微针阵列芯片的实施例一
微针阵列芯片如图1所示，基片1正面设有多个微针簇2，微针簇2呈矩形阵列状排列，多个微针簇2之间的横纵间距均为400微米。微针簇2的结构如图3所示，在微针簇2中，四个微针21围拢在一起，呈圆周阵列状排列或中心对称布置，微针21之间形成了十字形的通道，该通道也可以视为由两条相互垂直的矩形通道相交组成。在微针簇2中，每根微针21均为四棱锥，高度为300微米，微针21根部截面为正方形，边长为25微米。相邻两根微针21之间的间距均为50微米，也可以理解为十字形通道由两条相互垂直的、宽度为50微米的矩形通道组成。基片1背面设有储药池3，储药池3通过一个导液孔连接至基片正面，导液孔使基片正面和储药池流体联通，导液孔的直径为40微米，导液孔位于微针簇2中微针21之间的间隙中，也即十字形的通道中。
相比于现有的实心微针阵列芯片，本实施例提供的微针阵列芯片中，用微针簇2取代了现有技术中的实心微针，微针簇2穿透皮肤的作用原理和实心微针相同，用于穿透皮肤角质层，优选为通过促渗仪等设备产生高频振动来穿透角质层并在角质层留下微孔，可用于美容的活性成分或用于治疗的药用成分即可通过微孔穿过皮肤角质层，进入皮肤的深层结构，从而提高可用于美容的活性成分或用于治疗的药用成分的吸收效果。相比于现有技术，本实施例还取得了如下技术进步：微针簇2中微针21之间的间隙可以起到一定的携带效果，在微针簇2往复刺穿皮肤的过程中，该间隙可携带可用于美容的活性成分或用于治疗的药用成分进入皮肤的深层结构，而现有技术中的实心微针不具备这种携带能力，因此，本实施例相比于现有技术中中实心微针阵列芯片，可以更进一步提高可用于美容的活性成分或用于治疗的药用成分的吸收效果。
相比于现有的实心微针阵列芯片，本实施例还在基片1的背面增设了储药池3，如图2、4和5所示，储药池3可储藏一定量的可用于美容的活性成分或用于治疗的药用成分，可用于美容的活性成分或用于治疗的药用成分通过导液孔达到基片1的正面、微针簇2的通道之间，并在微针簇2穿刺角质层的过程中就随之穿过角质层、进入皮肤的深层结构中，从而实现了液械一体式的设计，在使用微针阵列芯片之前无需预先将可用于美容的活性成分或用于治疗的药用成分敷设于皮肤表面，从而达到了简化操作步骤、降低用户学习成本的效果。可用于美容的活性成分或用于治疗的药用成分通过导液孔的机制，近似于液械一体式促渗仪或水光枪等设备中液体从出液头出液的机制，可用于美容的活性成分或用于治疗的药用成分在微针阵列芯片往复振动过程中由于自身的惯性而从导液孔中被甩出。每一个微针簇2均设有一个对应的储药池3，储药池3之间通过浅槽4连接，可以使各个储药池3内的气压相同，使各微针簇2的出液效果一致。
 本发明的实施方式
微针阵列芯片的实施例二
基片1正面设有多个微针簇2，微针簇2呈矩形阵列状排列，微针簇2横纵间距均为300微米。微针簇2的结构如图6所示，微针簇2由两根微针21组成，两根微针均呈刀片状。两根微针的高度为300微米，两根微针之间的间距为50微米。
和实施例一相比，在实施例二中，一个微针簇2由两个微针21组成，微针21形状为刀片状，也可称为微型刀片。基片1背面不设有储药池，使用微针阵列芯片前需要预先将可用于美容的活性成分或用于治疗的药用成分敷设在皮肤表面。在实施例二中，两个微针21之间的间隙同样可以一定的携带效果，相比于现有技术中中实心微针阵列芯片，可以更进一步提高可用于美容的活性成分或用于治疗的药用成分的吸收效果。
微针阵列芯片的实施例三
基片1正面设有多个微针21，微针21呈矩形阵列状排列，微针21横纵间距均为300微米。微针21结构如图7、8和9所示，微针针体下部为棱柱、上部形成有两个三角形的尖部22，两个尖部22之间形成一个V形的槽23，槽深100微米，微针高度400微米。如图7、8和9所示，槽23的深度小于微针21的高度。
和现有技术中的实心微针阵列相比，在本实施例中，在微针尖部22形成一个槽结构，微针21穿透皮肤的作用原理和实心微针相同，用于穿透皮肤角质层，优选为通过促渗仪等设备产生高频振动来穿透角质层并在角质层留下微孔，可用于美容的活性成分或用于治疗的药用成分即可通过微孔穿过皮肤角质层，进入皮肤的深层结构，从而提高可用于美容的活性成分或用于治疗的药用成分的吸收效果。相比于现有技术，本实施例还取得了如下技术进步：微针尖部22的槽23可以起到一定的携带效果，在微针往复刺穿皮肤的过程中，该槽23可携带可用于美容的活性成分或用于治疗的药用成分进入皮肤的深层结构，而现有技术中的实心微针不具备这种携带能力，因此，本实施例相比于现有技术中中实心微针阵列芯片，可以更进一步提高可用于美容的活性成分或用于治疗的药用成分的吸收效果。和实施例一或二相比，本实施例采用的在微针尖部22开槽的结构，对现有实心微针的结构改动较小，工艺改变内容少，易于应用，槽结构对微针针体的物理性质破坏比较小，可保留现有实心微针制备工艺的优点和制成后的实心微针的优点，例如微针不易折断等。容易理解地是，当从微针尖部22向下开的槽23的深度等于微针高度时，在不增加制备工艺难度的前提下，即可使微针形成微针簇的结构。
微针阵列芯片的实施例四
基片1正面设有多个微针21，微针21呈矩形阵列状排列，微针21横纵间距均为400微米。微针结构如图10和11所示，基片1正面设有外轮廓为八面棱台的微针21，微针21顶部自上而下开设有矩形槽23，槽23的宽度均为15微米，槽23的深度为100微米，微针的高度为300微米，微针的底部直径为100微米，此时槽23的深度小于微针的高度。容易理解地是，当槽23的深度等于微针21的高度时，本实施例四中的微针形成类似实施例二中的微针簇结构。即实施例二中的微针簇2可以理解为本实施例四的一个特例。同理，实施例一中的微针簇可以理解为两条直槽交叉着从微针尖端向下开设至与微针相等的高度获得。
微针阵列芯片的实施例五
基片1正面设有多个微针21，微针21呈矩形阵列状排列，微针21横纵间距均为300微米。微针结构如图12和13所示，微针21针体下部为棱柱、上部形成有两个三角形的尖部22，两个尖部之间形成一个槽23，槽23的两个侧面为斜面，槽23底部宽40微米，槽23深100微米，微针高度400微米，槽23的深度小于微针21的高度。从基片1背面至槽23底面形成有通孔5，使微针21成为空心微针。
微针阵列芯片的实施例六
基片正面设有多个微针簇2，微针簇2呈矩形阵列状排列，微针簇2横纵间距均为300微米。微针簇2由两根微针21组成，两根微针21均呈刀片状。两根微针21的高度为300微米，两根微针之间的间距为10纳米。
微针阵列芯片的实施例七
基片正面设有多个微针簇2，微针簇2呈矩形阵列状排列，微针簇2横纵间距均为1000微米。微针簇2由两根微针21组成，两根微针21均呈刀片状。两根微针21的高度为500微米，两根微针21之间的间距为300微米。

Claims (19)

  1. 一种微针阵列芯片，包括基片和在基片正面呈阵列状排列的多个微针，其特征在于，由微针尖端向下开设有槽，槽的宽度不小于10nm，深度不小于50nm。
  2. 根据权利要求1所述的微针阵列芯片，其特征在于，所述微针包括上部和下部，其中，所述上部形成有尖部，所述尖部之间形成所述槽。
  3. 根据权利要求2所述的微针阵列芯片，其特征在于，所述尖部为三角形尖部。
  4. 根据权利要求1所述的微针阵列芯片，其特征在于，所述槽由微针尖端向下开设延伸，所述槽的深度小于所述微针的高度。
  5. 根据权利要求1所述的微针阵列芯片，其特征在于，所述槽由微针尖端向下开设延伸，所述槽的深度等于所述微针的高度。
  6. 根据权利要求1-5中任一项所述的微针阵列芯片，其特征在于，所述槽为V形槽。
  7. 根据权利要求1-5中任一项所述的微针阵列芯片，其特征在于，所述槽为矩形槽。
  8. 根据权利要求1-5中任一项所述的微针阵列芯片，其特征在于，所述槽的两个侧面为斜面。
  9. 根据权利要求1-5中任一项所述的微针阵列芯片，其特征在于，所述基片背面设有储药池，所述储药池和所述槽之间通过通孔实现流体连接。
  10. 根据权利要求9所述的微针阵列芯片，其特征在于，相邻所述储药池之间通过浅槽连接。
  11. 根据权利要求1-5中任一项所述的微针阵列芯片，其特征在于，还包括从所述槽底面延伸至基片背面的通孔。
  12. 根据权利要求1-5中任一项所述的微针阵列芯片，其特征在于，所述槽为一条直槽或由两条直槽以任意角度交叉组成。
  13. 一种微针阵列芯片，包括基片，其特征在于，所述基片正面设有呈阵列状排列的多个微针簇，每个微针簇由至少两个微针组成，每个微针簇中的微针之间的间隙不小于10nm且不大于300μm，微针簇内微针之间的间距小于微针阵列芯片上微针簇之间的间距。
  14. 根据权利要求13所述的微针阵列芯片，其特征在于，基片背面设有储药池，所述储药池底面和所述基片正面之间通过通孔实现流体连接，所述通孔位于微针簇中微针之间的位置。
  15. 根据权利要求14所述的微针阵列芯片，其特征在于，相邻所述储药池之间通过浅槽连接。
  16. 根据权利要求13所述的微针阵列芯片，其特征在于，还包括从所述基片正面延伸至基片背面的通孔，所述通孔位于微针簇中微针之间的位置。
  17. 根据权利要求13-16中任一项所述的微针阵列芯片，其特征在于，每个微针簇由两个微针组成。
  18. 根据权利要求13-16中任一项所述的微针阵列芯片，其特征在于，每个微针簇由两个以上的微针组成，且微针呈圆周排列。
  19. 根据权利要求13-16中任一项所述的微针阵列芯片，其特征在于，每个微针簇由四个微针组成，且四个所述微针呈圆周阵列状排列或中心对称布置。
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