WO2023106385A1 - 定量噴射型エアゾール - Google Patents

定量噴射型エアゾール Download PDF

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Publication number
WO2023106385A1
WO2023106385A1 PCT/JP2022/045384 JP2022045384W WO2023106385A1 WO 2023106385 A1 WO2023106385 A1 WO 2023106385A1 JP 2022045384 W JP2022045384 W JP 2022045384W WO 2023106385 A1 WO2023106385 A1 WO 2023106385A1
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Prior art keywords
aerosol
injection
solvent
drug
propellant
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Ceased
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PCT/JP2022/045384
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English (en)
French (fr)
Japanese (ja)
Inventor
惠理 原田
正太 水島
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Earth Corp
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Earth Corp
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Priority to AU2022407830A priority Critical patent/AU2022407830A1/en
Priority to JP2023566374A priority patent/JPWO2023106385A1/ja
Priority to CN202280081073.0A priority patent/CN118369394A/zh
Publication of WO2023106385A1 publication Critical patent/WO2023106385A1/ja
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A01N25/06—Aerosols
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P7/00—Arthropodicides
    • A01P7/04—Insecticides
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • C09K3/30—Materials not provided for elsewhere for aerosols

Definitions

  • the present invention relates to a metered injection type aerosol.
  • Patent Literature 1 describes an aerosol composition that contains an insecticide that is volatile at room temperature as an active ingredient and maintains the concentration of the active ingredient in the air for a long time by spraying a very small amount.
  • aerosols general continuous-injection aerosols and fixed-injection aerosols are known.
  • the fixed quantity injection type aerosol the amount of medicine ejected by one injection operation is fixed.
  • metered injection type aerosols there is room for investigation as to how to treat solid medicines at room temperature over a wider range and to increase their effectiveness.
  • the purpose of the present invention is to provide a means that can enhance the effect of a room-temperature solid drug in a treatment using a metered injection type aerosol.
  • the present invention relates to the following (1) to (3).
  • a constant injection type aerosol that has a pressure container and an aerosol composition filled in the pressure container and that injects a fixed amount of the aerosol composition in one injection operation, wherein the aerosol composition comprises a room temperature solid drug, a solvent and a propellant;
  • a metered injection aerosol wherein a latent heat of vaporization of a mixture comprising the solvent and the propellant is 10.00 kcal/mol or less.
  • the metered-dose aerosol according to (1) wherein the room-temperature solid agent is a room-temperature solid pest control component.
  • a metered injection type aerosol that injects a fixed amount of aerosol composition in one injection operation, and the latent heat of vaporization of the injected mixture consisting of the solvent and the propellant is within a specific range.
  • the room-temperature solid agent adheres to the treated surface extensively and uniformly. This can enhance the effect of the room-temperature solid drug.
  • FIG. 1 is a microscope photograph showing the state of chemical deposition after aerosol injection in Example 1.
  • FIG. FIG. 2 is a microscope photograph showing the state of chemical deposition after aerosol injection in Example 2.
  • FIG. 3 is a microscope photograph showing the state of chemical deposition after aerosol injection in Example 3.
  • FIG. 4 is a microscope photograph showing the state of chemical deposition after aerosol injection in Example 4.
  • FIG. 5 is a microscope photograph showing the state of chemical deposition after aerosol injection in Example 5.
  • FIG. FIG. 6 is a microscope photograph showing the state of chemical deposition after aerosol injection in Example 6.
  • FIG. 7 is a microscope photograph showing the chemical deposition state after the aerosol injection in Example 7.
  • FIG. FIG. 8 is a microscope photograph showing the state of chemical deposition after aerosol injection in Example 8.
  • FIG. 9 is a microscopic photograph showing the state of chemical deposition after the aerosol injection in Example 9.
  • FIG. 10 is a microscope photograph showing the chemical deposition state after the aerosol injection in Example 10.
  • FIG. 11 is a microscope photograph showing the state of chemical deposition after application of the chemical solution in Comparative Example 1.
  • FIG. 12 is a microscope photograph showing the state of chemical deposition after aerosol injection in Comparative Example 2.
  • FIG. 13 is a microscope photograph showing the state of chemical deposition after aerosol injection in Comparative Example 3.
  • FIG. FIG. 14 is a microscope photograph showing the state of chemical deposition after application of the chemical solution in Comparative Example 4.
  • FIG. 15 is a microscope photograph showing the state of chemical deposition after application of the chemical solution in Comparative Example 5.
  • FIG. 10 is a microscope photograph showing the chemical deposition state after the aerosol injection in Example 10.
  • FIG. 11 is a microscope photograph showing the state of chemical deposition after application of the chemical solution in Comparative Example 1.
  • FIG. FIG. 12 is a microscope photograph showing the state
  • the metered-dose aerosol of the present invention comprises a pressure-resistant container and an aerosol composition filled in the pressure-resistant container.
  • the aerosol composition contains a room-temperature solid drug (hereinafter also referred to as "medicine") as an active ingredient, a solvent, and a propellant.
  • the solid state at room temperature means that it is solid at room temperature, that is, around 25°C, and the vapor pressure at 25°C is preferably 25 mPa or less.
  • the room-temperature solid state includes, for example, a crystalline solid state, a powdery solid state, and the like.
  • An active ingredient refers to a substance that exerts some action when a metered dose aerosol is used.
  • the room-temperature solid drug that is the active ingredient but examples thereof include room-temperature solid pest control ingredients, aromatic ingredients, deodorizing ingredients, and disinfecting/sterilizing ingredients. Each component will be described below.
  • the pest control component is a component capable of killing, repelling (including flushing out), or knocking down target pests.
  • the type of pest control component is not particularly limited as long as it is solid at room temperature, and preferably has a vapor pressure of 25 mPa or less at 25°C. Also, known compounds can be used.
  • room-temperature solid pest control components include pyrethroid compounds such as phthalthrin, etofenprox, bifenthrin, and fenpropathrin; carbamate compounds such as propoxur; Organophosphorus compounds, oxadiazole compounds such as methoxadiazone, neonicotinoid compounds such as dinotefuran, metadiamide compounds such as brofuranilide, phenylpyrazole compounds such as fipronil, and others, pyriproxyfen, diflubenzuron, hydramethylnon, amidoflumet and the like. These may be used individually by 1 type, and may be used in combination of 2 or more type.
  • Target pests include, for example, flying pests such as mosquitoes, flies, moths, bees, gadflies, black flies, butterfly flies, midges, and leafhoppers, cockroaches, bedbugs, mites, stink bugs, ants, spiders, pill bugs, lice, centipedes, stink bugs, and ticks. , millipedes, termites, bark beetles, earthworms, earwigs, stains, fleas, triatomine bugs, longhorn beetles, deer beetles, bookworms, burs, and creeping pests, and crawling pests are preferred.
  • flying pests such as mosquitoes, flies, moths, bees, gadflies, black flies, butterfly flies, midges, and leafhoppers
  • cockroaches bedbugs, mites, stink bugs, ants, spiders, pill bugs, lice, centipedes, stink bugs, and ticks.
  • Room-temperature solid deodorant ingredients include sodium hypochlorite, baking soda, catechins (epicatechin gallate, epigallocatechin gallate, etc.), flavonoids, polyphenols, plant extracts (oyster tannin, green tea extract, grapefruit seed extract, yuzu seed extract), metal-based deodorants such as silver, copper and zinc. These may be used individually by 1 type, and may be used in combination of 2 or more type.
  • Normal-temperature solid disinfecting/sterilizing ingredients are ingredients that remove or kill microorganisms, molds, and bacteria.
  • disinfecting/sterilizing components include isopropylmethylphenol, chlorinated isocyanurate, cetylpyridinium chloride, thymol, hinokitiol, triclosan, methylparaben, ethylparaben, propylparaben, butylparaben, 4-chloro-3,5-dimethylphenol.
  • the above drugs can be used by combining ingredients with different effects.
  • the content of the drug is preferably 0.01 to 90% by mass/volume in terms of the total amount of the drug and solvent (hereinafter also referred to as "stock solution").
  • stock solution solvent
  • the lower limit of the drug content is more preferably 0.1% by mass/volume or more, still more preferably 0.3% by mass/volume or more, particularly preferably 0.5% by mass/volume or more, and 1% by mass/volume.
  • % by volume is most preferable, and the upper limit is more preferably 80% by mass/volume or less, further preferably 65% by mass/volume or less, particularly preferably 50% by mass/volume or less, and most preferably 15% by mass/volume.
  • the drug is solid at room temperature, it is preferably dissolved or dispersed in a solvent in the stock solution from the viewpoint of handling.
  • a volatile solvent is particularly preferred because it is required to dissolve or disperse the drug in the aerosol composition and to gradually volatilize after the aerosol composition is jetted to deposit the drug.
  • volatile solvents include organic solvents such as glycol ether solvents, hydrocarbon solvents, alcohol solvents, aromatic solvents, ester solvents, and water.
  • the volatile solvent is not particularly limited as long as it is volatile at room temperature, but the vapor pressure at 25° C. is preferably 50 Pa or more, more preferably 100 Pa or more, and particularly 1000 Pa or more. preferable.
  • a surfactant may also be used.
  • glycol ether solvents include propylene glycol monopropyl ether, propylene glycol monobutyl ether, dipropylene glycol monopropyl ether, dipropylene glycol monobutyl ether, dipropylene glycol dimethyl ether, ethylene glycol monoisobutyl ether, diethylene glycol monoisobutyl ether, and diethylene glycol. dibutyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether and the like.
  • hydrocarbon-based solvents include aliphatic hydrocarbons such as paraffinic hydrocarbons and naphthenic hydrocarbons, and alicyclic hydrocarbons, and kerosene such as JIS No.
  • 1 kerosene is preferred.
  • Specific examples include normal paraffin and isoparaffin.
  • Typical normal paraffins have 8 to 16 carbon atoms, and examples thereof include Neothiosol manufactured by Sanko Kagaku Kogyo Co., Ltd. and normal paraffin MA manufactured by ENEOS Corporation.
  • Isoparaffins typically have 8 to 16 carbon atoms, such as IP Clean LX manufactured by Idemitsu Kosan Co., Ltd., and the like.
  • alcohol solvents include lower alcohols such as ethanol, normal propanol and isopropanol, and polyhydric alcohols such as ethylene glycol.
  • aromatic solvents include toluene and xylene.
  • ester solvents examples include isopropyl myristate, hexyl laurate, isopropyl palmitate and the like.
  • alcoholic solvents are preferable, and lower alcohols such as ethanol, normal propanol, and isopropanol are more preferable because they are excellent in the solubility or dispersibility of the normal-temperature solid drug.
  • One of the above solvents may be used alone, or two or more thereof may be used in combination.
  • the stock solution can contain other ingredients as long as the effects of the present invention are not impaired.
  • Other components include, for example, preservatives, pH adjusters, ultraviolet absorbers, inorganic substances, surfactants, dissolution aids, and the like.
  • the content of the stock solution in the aerosol composition can be appropriately changed according to the purpose of use of the metered injection type aerosol and the combination with the propellant, and is not particularly limited. can be When the content of the stock solution in the aerosol composition is 1% by volume or more, the surface area of the drug remaining on the treated surface increases, so that the amount of pest insects that take up the drug and the frequency of contact with the drug can be increased. A good pest control effect can be obtained. In addition, when the content of the stock solution in the aerosol composition is 90% by volume or less, the stock solution can be sprayed as sprayed particles, so that, for example, the drug can be sufficiently and uniformly attached to the target site.
  • the lower limit is more preferably 5% by volume or more, and the upper limit is more preferably 70% by volume or less in the aerosol composition.
  • the propellant is a medium for injecting the undiluted liquid consisting of the drug and the solvent, and is pressure-filled into the pressure-resistant container together with the drug and the solvent.
  • the propellant include liquefied petroleum gas (LPG) such as propane, propylene, n-butane and isobutane, liquefied gas such as dimethyl ether (DME), compressed gas such as carbon dioxide, nitrogen gas, and compressed air, and HFC-152a. , HFC-134a, HFO-1234yf, HFO-1234ze, and other halogenated carbon gases.
  • LPG liquefied petroleum gas
  • DME dimethyl ether
  • the content of the propellant in the aerosol composition can be appropriately changed according to the purpose of use of the metered dose aerosol and the combination with the stock solution, and is not particularly limited.
  • the lower limit of the propellant content in the aerosol composition is more preferably 30% by volume or more, and the upper limit is more preferably 95% by volume or less.
  • the volume ratio of the stock solution to the propellant in the aerosol composition is preferably 1:99 to 90:10, more preferably 3:97 to 80:20, even more preferably 5:95 to 70:30. . By setting it as such a volume ratio, the effect of a sufficient chemical
  • the latent heat of vaporization of the mixture of solvent and propellant is 10.00 kcal/mol or less, preferably 9.80 kcal/mol or less. It is preferable that the latent heat of vaporization of the mixture of the solvent and the propellant is 10.00 kcal/mol or less, because the drug in the composition is unlikely to aggregate on the treated surface. Also, the latent heat of vaporization of the mixture of solvent and propellant is preferably 1.00 kcal/mol or more. When it is 1.00 kcal/mol or more, the drug in the composition spreads sufficiently on the treated surface, which is preferable.
  • the above latent heat of vaporization is a numerical value at 0° C. (273.15 K).
  • polar liquids refer to liquids composed of polar molecules, such as ethanol, isopropanol, isopropyl myristate, water, and dimethyl ether.
  • nonpolar liquids refer to liquids composed of molecules that do not have polarity, such as normal paraffin, isoparaffin, propane, butane, and ethane.
  • the metered-dose aerosol of the present invention comprises a pressure-resistant container and the aerosol composition filled in the pressure-resistant container.
  • the pressure container has its opening closed by an aerosol valve.
  • a fixed quantity injection type aerosol is an aerosol that injects a fixed amount of an aerosol composition in one injection operation.
  • a fixed quantity injection type aerosol is a spray member attached to an aerosol valve (hereinafter also referred to as a spray button) that is operated by the user to pass through the aerosol valve and spray a fixed amount of the aerosol composition in a pressure container.
  • the stock solution is granulated by a propellant and sprayed as spray particles.
  • the aerosol valve includes an opening/closing member for switching between communication and disconnection between the inside and the outside of the pressure vessel when the injection member is operated by the user, a housing to which the opening/closing member is attached, and the housing at a predetermined position in the pressure vessel.
  • a mounting member is provided for holding.
  • the opening/closing member includes a stem that slides up and down in conjunction with the injection member. By sliding the stem, communication (injection state) and blocking (non-injection state) of the aerosol composition are switched.
  • the aerosol valve is formed with a housing hole for taking in the aerosol composition from the pressure container and a stem hole for sending the taken in aerosol composition to the injection member.
  • the path from the housing bore to the stem bore constitutes an internal passageway through which the aerosol composition passes.
  • the aerosol valve is a fixed quantity type aerosol valve that performs a fixed quantity injection by operating the injection member once.
  • the injection amount of the aerosol valve can be set in the range of 0.1 mL or more in one injection operation, preferably in the range of 0.2 to 5 mL, more preferably in the range of 0.2 to 3 mL. It is By setting the injection amount within the above range, it is possible to efficiently spread the chemical agent on the surface to be treated while keeping the amount of the chemical agent to be injected to a very small amount. If the injection amount of the aerosol valve is within the above range, a predetermined injection amount can be appropriately set.
  • injection member is a member attached to the pressure container via the aerosol valve.
  • the injection button is formed with a passage in the operation part through which the aerosol composition taken in from the pressure container passes through the stem hole of the aerosol valve, and a nozzle hole through which the aerosol composition is injected.
  • the injection button may be a button type that is pressed from above, or may be a trigger type from the viewpoint of operability.
  • the inner diameter of the injection hole of the injection button is preferably ⁇ 0.45 to 3.0 mm, more preferably ⁇ 0.5 to 2.0 mm, and ⁇ 0. 6 to 1.6 mm is more preferred.
  • the injection button may have one or more injection holes having such an inner diameter.
  • the aerosol pressure container is filled with the aerosol composition as described above, and the injection member is operated to inject a fixed amount of the aerosol composition in one operation.
  • the ejection force of the aerosol composition at 25° C. at a position 20 cm away from the nozzle is preferably 1 to 60 gf, more preferably 5 to 40 gf.
  • the injection force was measured at a room temperature of 25° C. from a distance of 20 cm from the nozzle of the metered injection type aerosol, and a digital force gauge (for example, manufactured by Imada Co., Ltd., model number: DS2-2N). It can be determined by measuring the maximum value when the aerosol composition is injected once toward the center of the flat plate.
  • the aerosol composition ejected in the form of particles by injection adheres to the treated surface, aggregates while the solvent volatilizes, and precipitates the normal-temperature solid drug.
  • a drug precipitate can be observed under the following conditions.
  • the aerosol composition is sprayed toward the center of a vinyl chloride plate of 15 cm ⁇ 15 cm from a distance of 15 cm under conditions of about 15° C., and then air-dried for 1 hour.
  • An arbitrary section is set at a position 2.5 to 10 cm from the center of the plate, and the state of the crystal in the section is photographed. Crystals are photographed using a digital microscope (for example, Digital Microscope VHX-900 manufactured by KEYENCE).
  • the aerosol of the present invention preferably has an average particle diameter (D50) of 3 to 300 ⁇ m at an injection distance of 50 cm under conditions of about 25° C., from the viewpoint of the volatility of the injected particles.
  • the average particle size of the aerosol composition can be measured with a laser beam diffraction particle size analyzer (for example, "LDSA-1400A” manufactured by Microtrack Bell Co., Ltd.). Also, the average particle size of the aerosol composition can be adjusted by adjusting the internal pressure, the nozzle hole diameter, and the like.
  • the metered-volume aerosol of the present invention allows the drug to adhere uniformly over a wide area of the treatment surface.
  • the particle size distribution of the chemical deposit should be within a narrow range, and the difference between the maximum and minimum particle sizes of the chemical deposit should be small. That is, it is characterized in that the sizes of the drug deposits are uniform, and that the drug deposits can be evenly adhered without unevenness or gaps.
  • the chemical is an insect pest control component
  • the probability of contact between the insect pests adhering to the treated surface and the pest control component can be increased, and the pest control effect is likely to be exhibited.
  • An injection button having an injection hole diameter and the number of injection holes shown in Tables 1 and 2 was attached to an aerosol valve, and the injection amount per operation and the treatment amount of the pest control component were shown in Table 1.
  • Examples 1 to 13 A metered injection type aerosol of Comparative Examples 2 and 3 was obtained.
  • the drug solutions of Comparative Examples 1, 4, and 5 were dropped onto the center of one surface of a vinyl chloride plate measuring 15 cm long and 15 cm wide using a Pipetman (manufactured by Gilson).
  • the amount of the chemical solution dropped was such that the chemical treatment amount on the plate surface was the same as in the corresponding example.
  • the liquid was spread over the entire plate. After 1 hour at room temperature, the appearance of the drug deposit deposited on the surface of the vinyl chloride plate was observed using a microscope.
  • a plastic cup (diameter 13 cm, height 10 cm) was placed upside down on the vinyl chloride plate, and 10 German cockroaches were released into the cup and brought into contact with the vinyl chloride plate for a predetermined time. After standing for a certain period of time, the test insects were transferred to a clean cup, and the knockdown rate after 3 hours and the mortality rate after 24 hours were measured.
  • a vinyl chloride plate measuring 15 cm long and 15 cm wide was coated with petroleum jelly on its outer edge to prevent the escape of test insects, and was treated with a chemical agent by the following method.
  • a chemical treatment method in the case of the metered injection aerosol of Examples 7, 10, 11 to 13 a plate placed at an angle of 45° was sprayed from a distance of 75 cm toward the center of the plate. was operated once (1 push) and air-dried for 1 hour.
  • a trigger product number T-95 (manufactured by Canyon Co., Ltd.) was operated once with a hand pump to air-dry for 1 hour.
  • Adjusted fatality rate (%) (lethal rate in drug-treated area - lethal rate in drug-untreated area) / (1-lethal rate in drug-untreated area) x 100
  • Example 3 and Comparative Example 2 and between Example 8 and Comparative Example 4 even when the amount of pest control component treated is small, the knockdown rate and At least one of the lethality rates improved.
  • Example 2 and Comparative Example 2 comparison between Examples 3 and 4 and Comparative Example 3, comparison between Example 5 and Comparative Example 1, comparison between Example 7 and Comparative Example 4
  • the Example improved at least one of the knockdown rate and the lethality rate more than the Comparative Example.
  • Example 11 In the case of Dermatophagoides farinae, a comparison between Example 11 and Comparative Example 6 shows that when the type of pest control component and the treatment amount per operation are the same, the corrected lethality rate is higher in the example than in the comparative example. In addition, from the comparison between Examples 11 to 13 and Comparative Example 6, the corrected fatality rate was improved in the Examples compared to the Comparative Examples, regardless of the treatment amount of the pest control component, the average particle size, and the jetting force. Furthermore, from the results of Examples 7, 10 and 11, the Examples showed high corrected lethality regardless of the type of pest control component.
  • Example 1 (FIG. 1) and Example 2 (FIG. 2) with Comparative Example 2 (FIG. 12), Example 3 (FIG. 3) and Example 4 ( 4) and Comparative Example 3 (FIG. 13), Example 5 (FIG. 5) and Comparative Example 1 (FIG. 11), Example 7 (FIG. 7) and Comparative Example 4 (FIG. 14)
  • Example 10 (FIG. 10) and Comparative Example 5 (FIG. 15)
  • Comparative Example 5 (FIG. 15)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Insects & Arthropods (AREA)
  • Toxicology (AREA)
  • Dentistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PCT/JP2022/045384 2021-12-09 2022-12-08 定量噴射型エアゾール Ceased WO2023106385A1 (ja)

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AU2022407830A AU2022407830A1 (en) 2021-12-09 2022-12-08 Metered-spray aerosol
JP2023566374A JPWO2023106385A1 (https=) 2021-12-09 2022-12-08
CN202280081073.0A CN118369394A (zh) 2021-12-09 2022-12-08 定量喷射型气溶胶

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JP2021-200095 2021-12-09

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WO2021182433A1 (ja) * 2020-03-13 2021-09-16 大日本除蟲菊株式会社 特定有害物防除用定量噴射エアゾール製品、及びこれを用いた特定有害物防除方法

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TWI891015B (zh) * 2022-07-05 2025-07-21 日商大日本除蟲菊股份有限公司 防除屋內害蟲用之水性氣溶膠製品、防除屋內害蟲的方法，及防除屋內害蟲用之水性氣溶膠製品之使用方法

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