WO2023102758A1 - 含有吡唑化合物的杀虫组合物及其用途 - Google Patents

含有吡唑化合物的杀虫组合物及其用途 Download PDF

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Publication number
WO2023102758A1
WO2023102758A1 PCT/CN2021/136244 CN2021136244W WO2023102758A1 WO 2023102758 A1 WO2023102758 A1 WO 2023102758A1 CN 2021136244 W CN2021136244 W CN 2021136244W WO 2023102758 A1 WO2023102758 A1 WO 2023102758A1
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Prior art keywords
components
plants
composition according
pesticidal composition
component
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PCT/CN2021/136244
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English (en)
French (fr)
Inventor
罗昌炎
布里斯托詹姆斯·蒂莫西
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江苏龙灯化学有限公司
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Priority to PCT/CN2021/136244 priority Critical patent/WO2023102758A1/zh
Priority to CN202180095941.6A priority patent/CN117082979A/zh
Publication of WO2023102758A1 publication Critical patent/WO2023102758A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring

Definitions

  • the present application relates to an insecticidal composition containing a pyrazole compound represented by formula (I) and its use for controlling animal pests.
  • the present application also relates to a method for preventing and/or treating pest infestation in plants, plant propagation material and/or the surrounding environment with said pesticidal composition.
  • the activity of this substance is very good, but sometimes still insufficient at low application rates.
  • Chemical control is an important way to prevent or control pests in agriculture. However, it has been reported that more and more crops, fruits, vegetables and other pests develop resistance in the world. While alternating applications of insecticides with different modes of action can be used in good pest management practice, this approach may not always result in satisfactory pest control.
  • a pesticidal composition comprising a pyrazole compound of formula (I), which can reduce the dosage rate of the active ingredient It can still provide effective pest control effect.
  • the application relates to a pesticidal composition
  • component (A) is a pyrazole compound represented by formula (I)
  • component (B) is selected from chlorothiazide
  • insecticidal combinations that have been studied for pest control show that it is not easy to obtain a high synergistic control effect.
  • the pesticidal composition of the present application still exhibits a highly effective pest control effect, and obtains an unexpected synergistic effect.
  • synergistic effect refers to the synergistic effect obtained when two or more active compounds are combined, wherein the combined activity of the two or more active compounds exceeds the sum of the activities of the individual active compounds.
  • the pesticidal composition of the present application may preferably comprise the combination of following components:
  • the pesticidal composition of the present application more preferably comprises the combination of following components:
  • the weight ratio of components (A) and (B) in the pesticidal composition of the present application is preferably about 200:1 to about 1:200, preferably about 100:1 to about 1:100, more preferably About 50:1 to about 1:50, more preferably about 25:1 to about 1:25.
  • the weight ratio of components (A) and (B) in the pesticidal composition of the present application can be, for example, 200:1, 150:1, 120:1, 100:1, 90:1, 80:1 , 70:1, 60:1, 50:1, 40:1, 30:1, 20:1, 16:1, 15:1, 10:1, 5:1, 1:1, 1:5, 1 :10, 1:15, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 1:55, 1:60, 1:70, 1:80 , 1:90, 1:100, 1:120, 1:150 or 1:200.
  • the component (B) when the component (B) is selected from cyclopyrid, and the weight ratio of the components (A) and (B) is 25:1 to 1:25, for example, it can be 25:1, 20 :1, 16:1, 15:1, 10:1, 5:1, 1:1, 1:5, 1:10, 1:15, 1:20 or 1:25, preferably 10:1 to 1: 1, more preferably 5:1 to 1:1.
  • the component (B) is selected from flupyrfurone, and the weight ratio of the components (A) and (B) is 50:1 to 1:20, for example, it can be 50:1, 40 :1, 30:1, 20:1, 16:1, 15:1, 10:1, 5:1, 1:1, 1:5, 1:10, 1:15 or 1:20, preferably 20: 1 to 1:10, more preferably 16:1 to 1:5.
  • the component (B) is selected from chlorantraniliprole
  • the weight ratio of the components (A) and (B) is 10:1 to 1:50
  • it can be 10:1, 5:1, 1:1, 1:5, 1:10, 1:15, 1:20, 1:25, 1:30, 1:40 or 1:50, preferably 5:1 to 1:25, more Preferably 1:1 to 1:20.
  • the component (B) when the component (B) is selected from lufenuron, and the weight ratio of the components (A) and (B) is 50:1 to 1:50, for example, it can be 50:1, 40: 1, 30:1, 20:1, 16:1, 15:1, 10:1, 5:1, 1:1, 1:5, 1:10, 1:15, 1:20, 1:30, 1:40 or 1:50, preferably 40:1 to 1:40, more preferably 25:1 to 1:25.
  • the animal pests are selected from the order Thysanoptera, Diptera and Hemiptera.
  • the animal pests are selected from Thripidae and Aphididae pests.
  • a method of protecting a growing plant from animal pests by contacting the plant with a pesticidally effective amount of a pesticidal composition as described herein.
  • a method of protecting growing plants from animal pests, before and after plants, plant propagation material and/or their surroundings have been infested by pests.
  • a method of protecting seeds from soil insects and plant roots and shoots from soil and foliar insects comprising contacting the seeds with a pesticidal composition as described herein prior to sowing and/or after pre-germination.
  • Components (A) and (B) described herein can be applied and used in pure form as solid active compounds, for example in specific particle sizes, or preferably in customary formulation techniques together with at least one auxiliary , such as one or more inert fillers or surfactants.
  • Components (A) and (B) described herein may be present together in the pesticidal composition in suitable amounts, and are generally present in an amount of about 1 to about 90% by weight of the composition, e.g. 1% by weight, 5% by weight, 10% by weight, 20% by weight, 25% by weight, 30% by weight, 35% by weight, 40% by weight, 45% by weight, 50% by weight, 60% by weight, 70% by weight, 80% by weight % or 90% by weight; preferably from about 1 to about 60% by weight of the composition, more preferably from about 1 to about 40% by weight of the composition.
  • components (A) and (B) are used in the form of formulations together with one or more customary auxiliaries.
  • formulation types for premix compositions are: soluble concentrate (SL), emulsifiable concentrate (EC), emulsion in water (EW), microemulsion (ME), oily suspension (OD), suspension coating ( a flowable suspension) (FS), water dispersible granules (WG), soluble granules (SG), wettable powder (WP), soluble powder (SP), granules (GR), microencapsulated granules (CG ), fine granules (FG), coarse granules (GG), suspoemulsions (SE), microcapsule suspensions (CS), microparticles (MG), or preferably suspensions (SC).
  • Suitable inert fillers are known in the art and are commercially available.
  • Suitable solid inert fillers include, for example, clays (kaolin, diatomaceous earth, bentonite, acid clay, etc.), talc and its derivatives, ceramics, other inorganic minerals (andrite, quartz, activated carbon, calcium carbonate, hydrous oxide silicon, etc.), chemical fertilizers (ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, ammonium chloride, etc.)
  • Suitable liquid inert fillers include, for example, water; esters such as ethyl acetate and butyl acetate; amides such as N,N-dimethylformamide and N,N-dimethylacetamide; dimethylsulfoxide; Vegetable oils such as soybean oil, cottonseed oil, etc.
  • Suitable surfactants may be ionic or nonionic emulsifiers, dispersants or wetting agents.
  • Usable examples are salts of polyacrylic acid, lignosulfonic acid, benzenesulfonic acid or naphthalenesulfonic acid, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols (especially are alkylphenols), salts of sulfosuccinates, taurine derivatives (especially alkyl taurates), or polyethoxylated phosphate esters of phenols or alcohols.
  • the pesticidal composition is very effective in protecting crops from pests.
  • the pests are for example but not limited to: Orthoptera pests, Thysanoptera pests, Hemiptera pests, Coleoptera pests, Diptera pests, Lepidoptera pests, Hymenoptera, Acarina, Isoptera, ticks Mites and other harmful organisms. Examples of such harmful organisms include the following.
  • Pests of the order Hemiptera e.g. e.g. Aphididae, Adelgidae or Phylloxeridae, e.g. Macrosiphum avenae, Metopolophium dirhodum, grass Rhopalosiphum padi, Schizaphis graminum, Myzus persicae, Aphis gossypii, Aphis fabae, Aphis maidis (corn leaf aphid) , Acyrthosiphon pisum, Aulacorthum solani, Aphis craccivora, Macrosiphum euphorbiae, Brevicoryne brassicae, Lipaphis erysimi Aphis citricola, Rosy apple aphid, Eriosoma lanigerum, Toxoptera aurantii, and Toxoptera citricidus; leafhoppers (Cicadellidae), such as black Nephotetti
  • Thysanoptera pests such as Thrips palmi (Thrips palmi), Western flower thrips (Frankliniella occidentalis), tobacco thrips (Thrips alliorum (Priesner)), yellow-breasted thrips (Thrips hawaiiensis (Morgan), tea yellow thrips ( Scirtothrips dorsalis Hood), Frankliniella intonsa (Trybom), etc.;
  • Pests of the order Diptera for example: agromyzaoryzae, barley waterfly (hydrelliagriseola), gerbera leafminer (liriomyzatrifolii), pea leafminer (chromatomyiahorticola), tomato leafminer (liriomyzabryoniae), gray field fly (deliaplatura), onion fly (deliaantiqua), Mediterranean fruit fly (ceratitiscapiata wiedgman), apple fruit fly (Rhagoletis pomonella), cherry fruit fly (R. cingulata), etc.;
  • Pests of the order Lepidoptera for example Pyralidae such as chilosuppressalis (walker), tryporyzaincertulas (walker), rice leaf roller (cnaphalocrocismedinalis Guenee), cabbage borer (hellullaundalis), peach Conogethes punctiferlis; Pieridae such as Pieris rapae, papilioxuthus, pieris rapaecrucivora, parnaraguttata; Arctiidae such as American white moth (hyphantriacuunea); family Noctuidae such as trichoplusiani, cabbage armyworm (mamestrabrassicae), beet armyworm (spodoptera exigua), litura armyworm (spodoptera litura), cotton bollworm (helicoverpa armigera), Eastern armyworm (Pseudaletia separate), small cutworm (Agrotis ipsilon); Tortricidae such as
  • Coleopteran pests such as: rice weevil (sitophilus oryzae linne), citrus leafminer (Podagricomelanigricollis Che), corn weevil (S. zeamails), grain weevil (S. granarius), great ape leaf beetle (Cabbageleafbeetle), lesser ape beetle (Daikon leaf beele), Fleabeetle, Alticachalybea, Phyllottretastriolata, Epitrixcucumeris, Ehirtipennis, E.fuscula, Aulacophora indica (Gemlin), Rice water weevil (Lissorhoptrus oryzophilus), Callosobruchuys Kunststoffensis, Tenebrio molitor, Diabrotica virgifera virgifera, Cucumber beetle (Diabrotica undecimpunctata howardi), Verdant beetle (Anom al
  • Pests of the order Acarina e.g. Panonychus citri, Tetranychus cinnabarinus, Panonychus ulmi, Tetranychus urticae, Tetranychus viennensis, Tetranychus viennensis Oligonychus ununguis Eotetranychus kankitus, Brevipalpus phoenicis, Beyrobia redikorzeri, Aceria tulipae, Colomerus vitis , tea gall mite (calacarus carinatus), tea yellow mite (polyphagotarsonemus latus), long-haired root mite (rhizoglyphus rostochiensis), rough-legged mite (Acarussiro), citrus tumor mite (Aceriasheldoni), citrus gall mite (Aculusschlechtendali) , citrus rust mite (Phyllocoptes oleiverus ashmead), etc.;
  • Pests of the order Orthopteran for example Acrididae; megacopta punctatissimum, eurydemarugosum, eysarcorislewisi, eysarcorisparvus, nezaraviridula, Plautiastali, halymorphamista, cletus punctiger, leptocoris achinensis, stephantispyrioides, trigonotyluscoelestialium.
  • insects preferably sucking or piercing insects, such as insects from the orders Thysanoptera, Diptera and Hemiptera.
  • Thysanoptera pests such as Thrips palmi (Thrips palmi), Western flower thrips (Frankliniella occidentalis), tobacco thrips (Thrips alliorum (Priesner)), yellow-breasted thrips (Thrips hawaiiensis (Morgan), tea yellow thrips ( Scirtothrips dorsalis Hood), Frankliniella intonsa (Trybom), etc.;
  • Diptera pests such as agromyzaoryzae, hydrellia griseola, liriomyzatrifolii, chromatomyia horticola, liriomyzabryoniae, gray ground fly ( deliaplatura), onion fruit fly (delia antiqua), Mediterranean fruit fly (ceratitis scapiata wiedgman), apple fruit fly (Rhagoletis pomonella), cherry fruit fly (R. cingulata);
  • Hemiptera pests such as Aphididae, Adelgidae or Phylloxeridae such as Myzus persicae, Aphis gossypii, Aphis fabae, corn aphid (Aphis maidis) (corn leaf aphid), pea aphid (Acyrthosiphon pisum), eggplant aphid (Aulacorthum solani), bean aphid (Aphis craccivora), euphorbia aphid (Macrosiphum euphorbiae), wheat aphid (Macrosiphum avenae) ), Metopolophium dirhodum, Rhopalosiphum padi, Schizaphis graminum, Brevicoryne brassicae, Lipaphis erysimi, Spiraea aphid (Aphis citricola), rose apple aphid (Rosy apple aphid),
  • the pesticidal composition of the present application is especially useful for controlling Aphididae and Thripidae.
  • Macrosiphum euphorbiae Macrosiphum avenae, Metopolophium dirhodum, Rhopalosiphum padi, Schizaphis graminum, Smoke aphid (Myzus persicae), cotton aphid (Aphis gossypii), black bean aphid (Aphis fabae), corn aphid (Aphis maidis) (corn leaf aphid), pea aphid (Acyrthosiphon pisum), eggplant aphid (Aulacorthum solani), bean aphid Aphis craccivora, Brevicoryne brassicae, Lipaphis erysimi, Aphis citricola, Rosy apple aphid, Eriosoma lanigerum, Dickey aphid (Toxopter
  • the pesticidal composition of the present application is particularly important for controlling a large number of insects on various cultivated plants. It has surprisingly been found that when the insecticidal composition of the present application is applied to plants, plant propagation material and/or their surroundings, especially on cereals, root crops, oil crops, vegetables, spice crops, ornamental plants, such as durum wheat and other wheat, barley, oats, rye, corn, soybeans, oil crops, cruciferous, cotton, sunflower, banana, rice, oilseed rape, turnip rape, sugar beet, fodder beet, eggplant, potato, grass Grasses, lawns, turf, fodder grasses, tomatoes, leeks, squash, cabbage, thorn lettuce, peppers, cucumbers, melons, Brassica, melons, beans, peas, garlic, onions, carrots, tubers Excellent and synergistic performance in controlling and treating pest infestations is observed when applied to potatoes, sugar cane, tobacco, grapes. Plants refer to both growing crops and harvested plants.
  • the pesticidal compositions of the present application can be used to protect growing plants from attack or infestation by animal pests by contacting the plants with a pesticidally effective amount of the pesticidal compositions of the present application.
  • the application of the pesticidal composition of the present application can be carried out before and after the plants, plant propagation material and/or their surroundings are infested by pests.
  • the pesticidal compositions of the present application can also be used to protect growing plants from attack or infestation by pests by contacting the plants with a pesticidally effective amount of the pesticidal compositions of the present application.
  • Component (A) and component (B) may be administered in any desired order, in any combination, sequentially or simultaneously.
  • components (A) and (B) may be administered as a composition comprising components (A) and (B).
  • components (A) and (B) may be obtained from separate formulation sources and mixed together (known as tank-mix, ready-to-use, soup spray or slurry), Optionally with other pesticides, or components (A) and (B) can be obtained as a single formulation mixture source (known as premix, concentrate, formulated compound (or product)), and optionally mixed together with other pesticides .
  • the rate of application of the compositions of the present application may vary depending on factors such as, for example, the type of application, the type of crop, the particular active compound in the composition, the type of plant.
  • the formulations can be diluted with water at a rate of from about 1 to about 1000 grams of active ingredient per hectare, preferably at a rate of from about 10 to about 500 grams of active ingredient per hectare, and most preferably at a rate of from about 10 to about 300 grams of active ingredient. Ratio dilution of ingredients per hectare.
  • Plant refers to all plants and plant populations, such as desired or undesired wild plants or crop plants.
  • the pesticidal compositions of the present application are suitable for the treatment of plant propagation material, especially seeds, against pests, especially soil pests, and for the protection of the roots and shoots of the resulting plants from soil pests and foliar insects; preferably the protection of the roots and shoots of the resulting plants. More preferably the shoots of the resulting plants are protected from piercing-sucking insects, with protection from aphids being most preferred.
  • the present application provides a method of protecting seeds from soil insects and plant roots and shoots from soil and foliar insects, said method comprising combining seeds with the insecticides of the present application prior to sowing and/or after pre-germination object contact.
  • a method of protecting plant roots and shoots is particularly preferred, more preferably a method of protecting plant shoots from piercing-sucking insects, and most preferably a method of protecting plant shoots from aphids.
  • Suitable seeds are cereals, root crops, oil crops, vegetables, spice crops, seeds of ornamental plants such as durum and other wheat, barley, oats, rye, maize, soybeans, oil crops, cruciferous, cotton , sunflower, banana, rice, oilseed rape, turnip rape, sugar beet, fodder beet, eggplant, potato, grass, lawn, turf, fodder grass, tomato, leek, squash, cabbage, thorn lettuce, Peppers, cucumbers, melons, Brassica, melons, beans, peas, garlic, onions, carrots, tubers such as potatoes, sugar cane, tobacco, grapes, petunias, geraniums/geraniums, pansies and Seeds of impatiens.
  • Seed treatment includes all suitable seed treatment techniques known in the art, such as seed dressing, seed coating, seed dusting, seed soaking and seed pelleting.
  • the application rate of the insecticidal composition of the present application is usually 0.1g-10kg/100kg seeds, preferably 1g-5kg/100kg seeds, more preferably 1-1000g/100kg seeds, especially 1-200g/100kg seeds .
  • plant propagation material includes, but is not limited to, true seeds, seed pieces, suckers, corms, bulbs, fruits, tubers, grains, cuttings, cut shoots, etc., and in preferred embodiments Middle finger for real seeds.
  • the insecticidal composition containing the pyrazole compound provided by the present application exhibits highly effective pest control effect and obtains an unexpected synergistic effect.
  • Test example 1 Thrips test
  • Test object 2nd instar nymphs of Cucumber thrips yellow breast, the thrips for test were collected from the cucumber population on Dongfang Farm, Zhoushi Xinzhen, Kunshan, Jiangsu.
  • Test agent the components (A) and (B) were prepared as a mother solution with acetone, and then diluted with 0.1% Tween-80 aqueous solution to the required concentration.
  • the worms were inhaled by a self-made insect sucker, and then the test worms were ejected into the drug tubes, 20 per tube. All treatments were placed in a 25°C, 12H/12H light incubator for cultivation, and after 72 hours, the number of live insects was investigated, and the population reduction rate and control effect were calculated. Each treatment was repeated 4 times.
  • Decrease rate of insect population (%) (number of live insects before drug - number of live insects after drug) / number of live insects before drug ⁇ 100
  • Control effect% ((treatment group insect population decrease rate-control group insect population decrease rate)/(100-control group insect population decrease rate)) ⁇ 100
  • test example 2 The activity of test example 2 to two fork aphids
  • the active ingredients are applied as a dry seed dressing. It is prepared by mixing the active compound alone or a combination of active compounds with finely ground minerals to give a finely powdered composition which can be evenly distributed over the surface of the seed.
  • the soil and sand used in the experiment were from the same source and had not been treated with any pesticides.
  • Decrease rate of insect population (%) (number of live insects before drug - number of live insects after drug) / number of live insects before drug ⁇ 100
  • Control effect% ((treatment group insect population decrease rate-control group insect population decrease rate)/(100-control group insect population decrease rate)) ⁇ 100
  • Table 1 and Table 2 show that the pesticidal composition of the present application exhibits excellent and synergistic performance in controlling and treating pest infestation.

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

本申请涉及一种含有式(I)所示吡唑化合物的杀虫组合物及其用于防治动物害虫的用途。本申请还涉及所述的杀虫组合物预防和/或处理植物、植物繁殖材料和/或周围环境中害虫侵染的方法。

Description

含有吡唑化合物的杀虫组合物及其用途 技术领域
本申请涉及含有式(I)表示的吡唑化合物的杀虫组合物及其用于防治动物害虫的用途。本申请还涉及所述的杀虫组合物预防和/或处理植物、植物繁殖材料和/或周围环境中害虫侵染的方法。
背景技术
由下式(I)表示的吡唑化合物，其在专利文献WO2012/143317A1被描述，并且记载了其对各种有害生物，特别是对豇豆蚜、棉蚜、棉叶粉虱、稻飞虱、蓟马、菜蛾等显示出卓越的效果。该物质的活性很好，但在低施用量时有时仍有不足之处。
Figure PCTCN2021136244-appb-000001
化学控制是预防或控制农业中害虫的重要方式。但是世界上已报道越来越多的农作物、果实、蔬菜等的害虫产生抗性。虽然在良好害虫管理实践中可以采用交替施用具有不同作用模式的杀虫剂，但该方法未必总能获得令人满意的害虫防治效果。
为减少或避免因杀虫剂的施用造成的不利的环境或毒理学效应，本申请期望能够提供一种包含式(I)吡唑化合物的杀虫组合物，其能够在降低活性成分的剂量率下仍能够提供有效的害虫防治效果。
发明内容
本申请涉及一种杀虫组合物，包含组分(A)和组分(B)，组分(A)是由式(I)表示的吡唑化合物，组分(B)是选自氯噻啉、环氧虫啶、氟吡呋喃酮、哌虫啶、伊维菌素、吡丙醚、氯虫苯甲酰胺、甲氧虫酰肼、虱螨脲中的至少一 种化合物。
Figure PCTCN2021136244-appb-000002
已经研究的用于害虫防治的杀虫组合显示，获得高的协同防治效果并不容易。令人惊讶地是，在降低组分(A)和组分(B)的施用率下，甚至组分(A)和组分(B)在一个低施用率范围时变得完全无效的情况下，本申请的杀虫组合物仍旧表现了高度有效的害虫防治效果，获得了意想不到的协同效应。
本申请使用的术语“协同效应”是指两种或更多种活性化合物组合时所获得的协同作用，其中两种或更多种活性化合物的组合活性超过单独各活性化合物的活性总和。
协同效应的存在使用Colby S.R.,“Calculating Synergistic and Antagonistic Responses of Herbicide Combinations,”Weeds,1967,15,20–22中所述方法来确定。
本申请的杀虫组合物可优选地包含如下组分的组合：
(1)式I化合物和(B)氯噻啉；
(2)式I化合物和(B)环氧虫啶；
(3)式I化合物和(B)氟吡呋喃酮；
(4)式I化合物和(B)哌虫啶；
(5)式I化合物和(B)伊维菌素；
(6)式I化合物和(B)吡丙醚；
(7)式I化合物和(B)氯虫苯甲酰胺；
(8)式I化合物和(B)甲氧虫酰肼；以及
(9)式I化合物和(B)虱螨脲。
本申请的杀虫组合物更加优选地包含如下组分的组合：
(2)式I化合物和(B)环氧虫啶；
(3)式I化合物和(B)氟吡呋喃酮；
(7)式I化合物和(B)氯虫苯甲酰胺；以及
(9)式I化合物和(B)虱螨脲。
当组分(A)和(B)以特定重量比存在时，表现出特别明显的改善效果。具体而言，本申请的杀虫组合物中的组分(A)和(B)的重量比优选是约200:1至约1:200，优选约100:1至约1:100，更优选约50:1至约1:50，更优选约25:1至约1:25。
具体的，本申请的杀虫组合物中的组分(A)和(B)的重量比例如可以是200:1、150:1、120:1、100:1、90:1、80:1、70:1、60:1、50:1、40:1、30:1、20:1、16:1、15:1、10:1、5:1、1:1、1:5、1:10、1:15、1:20、1:25、1:30、1:35、1:40、1:45、1:50、1:55、1:60、1:70、1:80、1:90、1:100、1:120、1:150或1:200。
优选地，所述组分(B)选自环氧虫啶时，且所述组分(A)和(B)的重量比是25:1至1:25，例如可以是25:1、20:1、16:1、15:1、10:1、5:1、1:1、1:5、1:10、1:15、1:20或1:25，优选10:1至1:1，更优选5:1至1:1。
优选地，所述组分(B)选自氟吡呋喃酮时，且所述组分(A)和(B)的重量比是50:1至1:20，例如可以是50:1、40:1、30:1、20:1、16:1、15:1、10:1、5:1、1:1、1:5、1:10、1:15或1:20，优选20:1至1:10，更优选16:1至1:5。
优选地，所述组分(B)选自氯虫苯甲酰胺时，且所述组分(A)和(B)的重量比是10:1至1:50，例如可以是10:1、5:1、1:1、1:5、1:10、1:15、1:20、1:25、1:30、1:40或1:50，优选5:1至1:25，更优选1:1至1:20。
优选地，所述组分(B)选自虱螨脲时，且所述组分(A)和(B)的重量比是50:1至1:50，例如可以是50:1、40:1、30:1、20:1、16:1、15:1、10:1、5:1、1:1、1:5、1:10、1:15、1:20、1:30、1:40或1:50，优选40:1至1:40，更优选25:1至1:25。
本申请所述的杀虫组合物施用于植物、植物繁殖材料和/或其周围环境以防动物害虫侵袭的用途。所述动物害虫选自缨翅目类、双翅目类和半翅目类。
优选地，所述动物害虫选自蓟马科和蚜科害虫。
一种保护生长中的植物以防动物害虫侵袭的方法，使植物与杀虫有效量的本申请所述的杀虫组合物接触。
一种保护生长中的植物以防动物害虫侵袭的方法，在植物、植物繁殖材料和/或其周围环境被害虫侵染之前和之后进行。
一种保护种子以防土壤昆虫以及保护植物的根和芽以防土壤和叶面昆虫的 方法，包括在播种之前和/或在预萌发之后使种子与本申请所述的杀虫组合物接触。
本申请所述的组分(A)和(B)可以纯的形式作为固体活性化合物施用和使用，例如以具体的粒径使用，或优选地以常规制剂技术形式与至少一种助剂一起使用，例如一种或多种惰性填料或表面活性剂。
本申请所述的组分(A)和(B)可共同以合适的量存在于所述杀虫组合物中，并且通常存在的量为所述组合物的约1至约90重量％，例如1重量％、5重量％、10重量％、20重量％、25重量％、30重量％、35重量％、40重量％、45重量％、50重量％、60重量％、70重量％、80重量％或90重量％；优选为所述组合物的约1至约60重量％，更优选为所述组合物的约1至约40重量％。
通常，组分(A)和(B)与一种或多种的常规助剂一起形成的制剂形式使用。用于预混合组合物的制剂类型的例子有：可溶液剂(SL)、乳油(EC)、水乳剂(EW)、微乳剂(ME)、油型悬浮剂(OD)、悬浮种衣剂(a flowable suspension)(FS)、水分散粒剂(WG)、可溶粒剂(SG)、可湿性粉剂(WP)、可溶粉剂(SP)、颗粒剂(GR)、微囊粒剂(CG)、细颗粒(FG)、粗颗粒(GG)、悬乳剂(SE)、微囊悬浮剂(CS)、微颗粒(MG)、或优选悬浮剂(SC)。
适用的惰性填料是本领域已知的并且市售可得。合适的固体惰性填料包括，例如，粘土类(高岭土、硅藻土、膨润土、酸性白土等)、滑石及其衍生物、陶瓷、其它无机矿物(钙铁石、石英、活性碳、碳酸钙、水合氧化硅等)、化学肥料(硫酸铵、磷酸铵、硝酸铵、尿素、氯化铵等)等的微粉末或粒状物等。合适的液体惰性填料包括，例如，水；乙酸乙酯、乙酸丁酯等酯类；N,N-二甲基甲酰胺、N,N-二甲基乙酰胺等酰胺类；二甲亚砜；大豆油、棉子油等植物油等。
适用的表面活性剂可以是离子型或非离子型的乳化剂、分散剂或润湿剂。可用的示例有聚丙烯酸的盐、木质素磺酸的盐、苯磺酸或萘磺酸的盐、环氧乙烷与脂肪醇或与脂肪酸或与脂肪胺的缩聚物、经取代的酚(尤其是烷基酚)、磺基琥珀酸酯的盐、牛磺酸衍生物(尤其是烷基牛磺酸盐)，或聚乙氧基化的酚或醇的磷酸酯。
所述杀虫组合物对于保护作物免受害虫侵袭方面是非常有效的。所述害虫例如但不限于：直翅目害虫、缨翅目害虫、半翅目害虫、鞘翅目害虫、双翅目害虫、鳞翅目害虫、膜翅目、蜱螨目、等翅目、蜱螨目害虫等有害生物。作为 这样的有害生物的例子，可例示出如下。
半翅目害虫，例如：如蚜科(Aphididae)、球蚜科(Adelgidae)或根瘤蚜科(Phylloxeridae)，如麦长管蚜(Macrosiphum avenae)、麦无网长管蚜(Metopolophium dirhodum)、禾谷缢管蚜(Rhopalosiphum padi)、麦二叉蚜(Schizaphis graminum)、烟蚜(Myzus persicae)、棉蚜(Aphis gossypii)、黑豆蚜(Aphis fabae)、玉米蚜(Aphis maidis)(玉米叶蚜)、豌豆蚜(Acyrthosiphon pisum)、茄无网蚜(Aulacorthum solani)、豆蚜(Aphis craccivora)、大戟长管蚜(Macrosiphum euphorbiae)、甘蓝蚜(Brevicoryne brassicae)、萝卜蚜(Lipaphis erysimi)、绣线菊蚜(Aphis citricola)、玫瑰苹果蚜(Rosy apple aphid)、苹果绵蚜(Eriosoma lanigerum)、桔二叉蚜(Toxoptera aurantii)和大桔蚜(Toxoptera citricidus)；叶蝉科(Cicadellidae)，如黑尾叶蝉(Nephotettix cincticeps)；飞虱科(Delphacidae)，如灰飞虱(Laodelphax striatellus)、褐飞虱(Nilaparvatalugens)和白背飞虱(Sogatella furcifera)；蝽科(Pentatomidae)，例如白星蝽象(Eysarcoris ventralis)、稻绿蝽(Nezara viridula)；粉虱科(Aleyrodidae)，例如烟粉虱(Bemisia tabaci)和温室粉虱(Trialeurodes vaporariorum)；盾蚧科(Diaspididae)、蛛蚧科(Margarodidae)、旌蚧科(Ortheziidae)、仁蚧科(Aclerdiae)、胭蚧科(Dactylopiidae)、胶蚧科(Kerridae)、粉蚧科(Pseudocoddidae)；蜡蚧科(Coccidae)；绒蚧科(Eriococcidae)；链蚧科(Asterolecaniidae)、球链蚧科(Lecanodiaspididae)；或壶蚧科(Cerococcidae)，例如康氏粉蚧(Pseudococcus comstocki)和柑橘粉介壳虫(Planococcus citri Risso)；木虱科(Psyllidae)如梨木虱(psyllapyrisuga)、柑橘木虱(diaphorinatabaci)；
缨翅目害虫，例如棕榈蓟马(Thrips palmi)、西花蓟马(Frankliniella occidentalis)、烟蓟马(Thrips alliorum(Priesner))、黄胸蓟马(Thrips hawaiiensis(Morgan)、茶黄蓟马(Scirtothrips dorsalis Hood)、花蓟马(Frankliniella intonsa(Trybom)等；
双翅目害虫，例如：稻潜蝇(agromyzaoryzae)、大麦水蝇(hydrelliagriseola)、非洲菊斑潜蝇(liriomyzatrifolii)、豌豆叶潜蝇(chromatomyiahorticola)、番茄斑潜蝇(liriomyzabryoniae)、灰地种蝇(deliaplatura)、葱地种蝇(deliaantiqua)地中海实蝇(ceratitiscapiata wiedgman)、苹果实蝇(Rhagoletis pomonella)、樱桃实蝇(R.cingulata)等；
鳞翅目害虫，例如螟蛾科(Pyralidae)例如二化螟(chilosuppressalis(walker)、三化螟(Tryporyzaincertulas(walker))、稻纵卷叶螟(cnaphalocrocismedinalis Guenee)、菜心螟(hellullaundalis)、桃蛀螟(conogethes punctiferlis)；粉蝶科(Pieridae)例如菜粉蝶(Pieris rapae)、柑桔凤蝶(papilioxuthus)、白粉蝶(pierisrapaecrucivora)、直纹稻弄蝶(parnaraguttata)；灯蛾科(Arctiidae)如美国白蛾(hyphantriacunea)；夜蛾科(Noctuidae)如粉纹夜蛾(trichoplusiani)、甘蓝夜蛾(mamestrabrassicae)、甜菜夜蛾(spodopteraexigua)、斜纹夜蛾(spodopteralitura)、棉铃虫(helicoverpa armigera)、东方粘虫(Pseudaletia separate)、小地老虎(Agrotis ipsilon)；卷蛾科(Tortricidae)如茶小卷叶蛾(adoxophyes orana fasciata)、杏黄卷蛾(archipsfuscocureanus)、茶长卷蛾(homona magnanima)；菜蛾科(Plutellidae)如小菜蛾(plutellaxylotella)；麦蛾科(Gelechiidae)如棉红铃虫(pectinophora gossypiella)、红铃麦蛾(Pink bollworm)等；
鞘翅目害虫，例如：米象(sitophilus oryzae linne)、柑橘潜叶甲(PodagricomelanigricollisChe)、玉米象(S.zeamails)、谷象(S.granarius)、大猿叶虫(Cabbageleafbeetle)、小猿叶虫(Daikon leaf beele)，跳甲(fleabeetle)、葡萄跳甲(Alticachalybea)、曲条跳甲(phyllotretastriolata)、黄瓜跳甲(Epitrixcucumeris)、烟草跳甲(Ehirtipennis)、茄跳甲(E.fuscula)、黄守瓜(Aulacophoraindica(Gemlin)、稻水象甲(Lissorhoptrus oryzophilus)、Callosobruchuys chienensis、黄粉虫(Tenebrio molitor)、玉米根萤叶甲(Diabrotica virgifera virgifera)、黄瓜甲虫(Diabrotica undecimpunctata howardi)、铜绿金龟(Anomala cuprea)、红铜丽金龟(Anomala rufocuprea)、黄曲条菜跳甲(Phyllotreta striolata)、黄守瓜(Aulacophora femoralis)、马铃薯甲虫(Leptinotarsa decemlineata)、稻负泥虫(Oulema oryzae)和天牛科(Cerambycidae)等；
蜱螨目的害虫，例如柑橘全爪螨(panonychus citri)、朱砂叶螨(Tetranychus cinnabarinus)、苹果全爪螨(panony ulmi)、二斑叶螨(tetranychus urticae)、山楂叶螨(tetranychus viennensis)、针叶小爪螨(oligonychus ununguis)柑橘始叶螨(eotetranychus kankitus)、紫红短须螨(brevipalpus phoenicis)、苜蓿苔螨(beyrobia redikorzeri)、小麦卷叶螨(aceria tulipae)、葡萄瘿螨(colomerus vitis)、茶叶瘿螨(calacarus carinatus)、茶黄螨(polyphagotarsonemus latus)、长毛根螨 (rhizoglyphus rostochiensis)、粗脚粉螨(Acarussiro)、柑橘瘤瘿螨(Aceriasheldoni)、斯氏针刺瘿螨(Aculusschlechtendali)、柑橘锈螨(Phyllocoptes oleiverus ashmead)等；
直翅目(Orthopteran)害虫，例如剑角蝗科(Acrididae)；臭蝽(megacoptapunctatissimum)、菜蝽(eurydemarugosum)、大刺白星蝽(eysarcorislewisi)、白星蝽(eysarcorisparvus)、稻绿蝽(nezaraviridula)、斯氏珀蝽(plautiastali)、臭梧桐蝽(halymorphamista)、稻棘缘蝽(cletuspunctiger)、中华稻缘蝽(leptocorisachinensis)、杜鹃网蝽(stephantispyrioides)、赤须盲蝽(trigonotyluscoelestialium)。
本申请的杀虫组合物尤其可用于防治昆虫，优选吮吸或刺吸式昆虫，例如来自缨翅目类、双翅目类和半翅目类的昆虫。
缨翅目害虫，例如棕榈蓟马(Thrips palmi)、西花蓟马(Frankliniella occidentalis)、烟蓟马(Thrips alliorum(Priesner))、黄胸蓟马(Thrips hawaiiensis(Morgan)、茶黄蓟马(Scirtothrips dorsalis Hood)、花蓟马(Frankliniella intonsa(Trybom)等；
双翅目害虫，例如稻潜蝇(agromyzaoryzae)、大麦水蝇(hydrelliagriseola)、非洲菊斑潜蝇(liriomyzatrifolii)、豌豆叶潜蝇(chromatomyiahorticola)、番茄斑潜蝇(liriomyzabryoniae)、灰地种蝇(deliaplatura)、葱地种蝇(deliaantiqua)地中海实蝇(ceratitiscapiata wiedgman)、苹果实蝇(Rhagoletis pomonella)、樱桃实蝇(R.cingulata)；
半翅目害虫，例如蚜科(Aphididae)、球蚜科(Adelgidae)或根瘤蚜科(Phylloxeridae)，如烟蚜(Myzus persicae)、棉蚜(Aphis gossypii)、黑豆蚜(Aphis fabae)、玉米蚜(Aphis maidis)(玉米叶蚜)、豌豆蚜(Acyrthosiphon pisum)、茄无网蚜(Aulacorthum solani)、豆蚜(Aphis craccivora)、大戟长管蚜(Macrosiphum euphorbiae)、麦长管蚜(Macrosiphum avenae)、麦无网长管蚜(Metopolophium dirhodum)、禾谷缢管蚜(Rhopalosiphum padi)、麦二叉蚜(Schizaphis graminum)、甘蓝蚜(Brevicoryne brassicae)、萝卜蚜(Lipaphis erysimi)、绣线菊蚜(Aphis citricola)、玫瑰苹果蚜(Rosy apple aphid)、苹果绵蚜(Eriosoma lanigerum)、桔二叉蚜(Toxoptera aurantii)和大桔蚜(Toxoptera citricidus)；叶蝉科(Cicadellidae)，如黑尾叶蝉(Nephotettix cincticeps)；飞虱 科(Delphacidae)，如灰飞虱(Laodelphax striatellus)、褐飞虱(Nilaparvatalugens)和白背飞虱(Sogatella furcifera)；蝽科(Pentatomidae)，例如白星蝽象(Eysarcoris ventralis)、稻绿蝽(Nezara viridula)；粉虱科(Aleyrodidae)，例如烟粉虱(Bemisia tabaci)和温室粉虱(Trialeurodes vaporariorum)；盾蚧科(Diaspididae)、蛛蚧科(Margarodidae)、旌蚧科(Ortheziidae)、仁蚧科(Aclerdiae)、胭蚧科(Dactylopiidae)、胶蚧科(Kerridae)、粉蚧科(Pseudocoddidae)；蜡蚧科(Coccidae)；绒蚧科(Eriococcidae)；链蚧科(Asterolecaniidae)、球链蚧科(Lecanodiaspididae)；或壶蚧科(Cerococcidae)，例如康氏粉蚧(Pseudococcus comstocki)和柑橘粉介壳虫(Planococcus citri Risso)；木虱科(Psyllidae)如梨木虱(psyllapyrisuga)、柑橘木虱(diaphorinatabaci)。
本申请杀虫组合物尤其可用于防治蚜科和蓟马科。例如大戟长管蚜(Macrosiphum euphorbiae)、麦长管蚜(Macrosiphum avenae)、麦无网长管蚜(Metopolophium dirhodum)、禾谷缢管蚜(Rhopalosiphum padi)、麦二叉蚜(Schizaphis graminum)、烟蚜(Myzus persicae)、棉蚜(Aphis gossypii)、黑豆蚜(Aphis fabae)、玉米蚜(Aphis maidis)(玉米叶蚜)、豌豆蚜(Acyrthosiphon pisum)、茄无网蚜(Aulacorthum solani)、豆蚜(Aphis craccivora)、甘蓝蚜(Brevicoryne brassicae)、萝卜蚜(Lipaphis erysimi)、绣线菊蚜(Aphis citricola)、玫瑰苹果蚜(Rosy apple aphid)、苹果绵蚜(Eriosoma lanigerum)、桔二叉蚜(Toxoptera aurantii)和大桔蚜(Toxoptera citricidus)；棕榈蓟马(Thrips palmi)、西花蓟马(Frankliniella occidentalis)、烟蓟马(Thrips alliorum(Priesner))、黄胸蓟马(Thrips hawaiiensis(Morgan))、茶黄蓟马(Scirtothrips dorsalis Hood)、花蓟马(Frankliniella intonsa(Trybom))等。
本申请的杀虫组合物在各种栽培植物上防除大量昆虫特别重要。已惊讶地发现当在植物、植物繁殖材料和/或其周围环境施用本申请的杀虫组合物时特别是在禾谷类、根系作物、油料作物、蔬菜、香料作物、观赏植物，例如硬粒小麦和其他小麦、大麦、燕麦、黑麦、玉米、大豆、油料作物、十字花科、棉花、向日葵、香蕉、稻、油籽油菜、芜菁油菜、糖用甜菜、饲料甜菜、茄子、土豆、禾草、草坪、草皮、饲料禾草、西红柿、韭葱、南瓜、卷心菜、刺茎莴苣、胡椒、黄瓜、甜瓜、芸苔属(Brassica)、甜瓜、菜豆、豌豆、大蒜、洋葱、胡萝卜、块茎植物如土豆、甘蔗、烟草、葡萄施用时，可观察到在防治和处理害虫侵袭 方面的卓越且协同的性能。植物是指生长中的作物和已收获的植物。
本申请杀虫组合物可用于通过使植物与杀虫有效量的本申请杀虫组合物接触来保护生长中的植物以防动物害虫侵袭或侵染。本申请的杀虫组合物施用可以在植物、植物繁殖材料和/或其周围环境被害虫侵染之前和之后进行。
本申请的杀虫组合物还可用于保护生长中的植物以防害虫侵袭或侵染，其通过使该植物与杀虫有效量的本申请的杀虫组合物接触来实施。
组分(A)和组分(B)可以任何所需次序、任何组合，连续或同时施用。另外，在组分(A)和(B)同时施用的情况中，其可以作为包含组分(A)和(B)的组合物来施用。在该情况中，组分(A)和(B)可获自分开的制剂来源并混合在一起(称为罐混型(tank-mix)、即用型、喷汤型或浆料型)，任选伴随其它农药，或组分(A)和(B)可作为单一制剂混合物来源获得(称为预混型、浓缩型、配方化合物(或产品))，并任选与其它农药混合在一起。
本申请的组合物的施用率可根据如下因素而变化，例如，根据应用类型、作物类型、组合物中特定活性化合物、植物类型。通常，制剂可用水以约1至约1000克活性组分每公顷的比例稀释，优选比例为约10至约500克活性成分每公顷的比例稀释，最优选的比例为约10至约300克活性成分每公顷的比例稀释。
本文中所用的“植物”，指的是所有植物和植物种群，例如需要或不需要的野生植物或作物植物。
本申请杀虫组合物适用于处理植物繁殖材料尤其是种子，以防害虫尤其是土壤害虫以及保护所得植物的根和芽以防土壤害虫和叶面昆虫；优选保护所得植物的根和芽。更优选保护所得植物的芽以防刺吸式昆虫，其中最优选保护以防蚜虫。
本申请提供一种保护种子以防土壤昆虫以及保护植物的根和芽以防土壤和叶面昆虫的方法，所述方法包括在播种之前和/或在预萌发之后使种子与本申请的杀虫组合物接触。特别优选一种保护植物的根和芽的方法，更优选一种保护植物芽以防刺吸式昆虫的方法，最优选一种保护植物芽以防蚜虫的方法。
合适的种子为禾谷类、根系作物、油料作物、蔬菜、香料作物、观赏植物的种子，例如硬粒小麦和其他小麦、大麦、燕麦、黑麦、玉米、大豆、油料作物、十字花科、棉花、向日葵、香蕉、稻、油籽油菜、芜菁油菜、糖用甜菜、 饲料甜菜、茄子、土豆、禾草、草坪、草皮、饲料禾草、西红柿、韭葱、南瓜、卷心菜、刺茎莴苣、胡椒、黄瓜、甜瓜、芸苔属(Brassica)、甜瓜、菜豆、豌豆、大蒜、洋葱、胡萝卜、块茎植物如土豆、甘蔗、烟草、葡萄、矮牵牛、天竺葵/香叶天竺葵、三色堇和凤仙花的种子。
对种子的施用在播种之前进行，直接施用在种子上或在种子已经预萌发之后施用。种子处理包括所有本领域已知的合适种子处理技术，如拌种、种子涂敷、种子撒粉、种子浸泡和种子压丸。
在种子处理中，本申请的杀虫组合物的施用率通常为0.1g-10kg/100kg种子，优选1g-5kg/100kg种子，更优选1-1000g/100kg种子，尤其是1-200g/100kg种子。
术语“植物繁殖材料”包括但不限于真正的种子、种子切片(seed piece)、吸枝、球茎、鳞茎、果实、块茎、谷粒、插条、伐条(cut shoot)等，并且在优选实施方案中指真正的种子。
与现有技术相比，本申请至少具有以下有益效果：
本申请所提供的含有吡唑化合物的杀虫组合物表现了高度有效的害虫防治效果，获得了意想不到的协同效应。
具体实施方式
生物测试：
试验例1蓟马的试验
供试对象：黄瓜黄胸蓟马2龄若虫，供试蓟马采自江苏昆山周市新镇东方农场黄瓜上种群。
试验药剂：将组分(A)、组分(B)原药用丙酮配制成母液，再用0.1％的吐温-80水溶液稀释至所需的浓度。
用小刀将鲜嫩的豇豆豆荚切成长度为2cm左右的片段(豆荚两端平整，不留豆粒孔，便于结果调查)，在药液中浸渍15s，以清水(含溶剂及吐温)作为对照。处理后的果荚置于吸水纸上自然晾干，用小镊子夹入离心管中，每管1节。
采用自制吸虫器将虫吸入，然后将试虫弹入药管中，每管20头。将所有处理放置在25℃，12H/12H光照培养箱内培养，72h后调查活虫数，并计算虫口 减退率和防效。每个处理重复4次。
计算方法：
虫口减退率(％)＝(药前活虫数-药后活虫数)/药前活虫数×100
防效％＝((处理组虫口减退率-对照组虫口减退率)/(100-对照组虫口减退率))×100
表1 式I所示化合物和组分(B)的组合对蓟马的防效
Figure PCTCN2021136244-appb-000003
试验例2对麦二叉蚜的活性
活性组分以干种子拌种剂施用。通过将单独的活性化合物或活性化合物的组合物与磨细的矿物质混合来制备，得到能在种子表面均匀分布的细粉状组合物。
种子拌种时，先将各个药剂按设计剂量调成浆状液，然后将种子和药液在封闭的玻璃烧瓶内摇动3分钟，待种子均匀着药后，倒出摊开置于通风处，晾干后播种。
试验用土壤和砂来源相同且未经过任何农药处理。每个处理60粒小麦种子，3次重复，每个重复20粒。将所有处理的花盆置于15℃的可控日光温室中。观察作物的生长状况。出苗后每盆定植为15株小麦植株。出苗后第7天，每盆接10只麦二叉蚜。接虫后5天，计数活的蚜虫，并计算虫口减退率及防效。
计算方法：
虫口减退率(％)＝(药前活虫数-药后活虫数)/药前活虫数×100
防效％＝((处理组虫口减退率-对照组虫口减退率)/(100-对照组虫口减退率))×100
表2 式I化合物和组分(B)的组合对麦二叉蚜的活性
Figure PCTCN2021136244-appb-000004
Figure PCTCN2021136244-appb-000005
表1和表2表明，本申请的杀虫组合物在防治和处理害虫侵袭方面表现出卓越且协同的性能。

Claims (13)

  1. 一种含有吡唑化合物的杀虫组合物，其含有组分(A)和(B)，
    组分(A)是式(I)表示的吡唑化合物；组分(B)是选自氯噻啉、环氧虫啶、氟吡呋喃酮、哌虫啶、伊维菌素、吡丙醚、氯虫苯甲酰胺、甲氧虫酰肼、虱螨脲中的至少一种化合物；
    Figure PCTCN2021136244-appb-100001
    且所述组分(A)和(B)的重量比是200:1至1:200。
  2. 根据权利要求1所述的杀虫组合物，其中，所述组分(A)和(B)的重量比是100:1至1:100，优选50:1至1:50，更优选25:1至1:25。
  3. 根据权利要求1所述的杀虫组合物，其中，所述组分(B)选自环氧虫啶，且所述组分(A)和(B)的重量比是25:1至1:25，优选10:1至1:1，更优选5:1至1:1。
  4. 根据权利要求1所述的杀虫组合物，其中，所述组分(B)选自氟吡呋喃酮，且所述组分(A)和(B)的重量比是50:1至1:20，优选20:1至1:10，更优选16:1至1:5。
  5. 根据权利要求1所述的杀虫组合物，其中，所述组分(B)选自氯虫苯甲酰胺，且所述组分(A)和(B)的重量比是10:1至1:50，优选5:1至1:25，更优选1:1至1:20。
  6. 根据权利要求1所述的杀虫组合物，其中，所述组分(B)选自虱螨脲，且所述组分(A)和(B)的重量比是50:1至1:50，优选40:1至1:40，更优选25:1至1:25。
  7. 权利要求1所述的杀虫组合物施用于植物、植物繁殖材料和/或其周围环境以防动物害虫侵袭的用途。
  8. 根据权利要求7所述的用途，所述动物害虫选自缨翅目类、双翅目类和半翅目类。
  9. 根据权利要求8所述的用途，所述动物害虫选自蓟马科和蚜科害虫。
  10. 一种保护生长中的植物以防动物害虫侵袭的方法，其中，使植物与杀虫有效量的权利要求1所述的杀虫组合物接触。
  11. 根据权利要求10所述的方法，其中，在植物、植物繁殖材料和/或其周围环境被害虫侵染之前和之后使植物与杀虫有效量的权利要求1所述的杀虫组合物接触。
  12. 一种保护生长中的植物以防动物害虫侵袭的方法，其中，使植物与权利要求1所述的杀虫组合物接触。
  13. 一种保护种子以防土壤昆虫以及保护植物的根和芽以防土壤和叶面昆虫的方法，其包括在播种之前和/或在预萌发之后使种子与权利要求1所述的杀虫组合物接触。
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