WO2023036281A1 - Anticorps anti-cd47 et son utilisation - Google Patents

Anticorps anti-cd47 et son utilisation Download PDF

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WO2023036281A1
WO2023036281A1 PCT/CN2022/118015 CN2022118015W WO2023036281A1 WO 2023036281 A1 WO2023036281 A1 WO 2023036281A1 CN 2022118015 W CN2022118015 W CN 2022118015W WO 2023036281 A1 WO2023036281 A1 WO 2023036281A1
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seq
antibody
antigen
amino acid
variable region
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PCT/CN2022/118015
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Chinese (zh)
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郎国竣
胡宇豪
谭永聪
闫鑫甜
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三优生物医药(上海)有限公司
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Publication of WO2023036281A1 publication Critical patent/WO2023036281A1/fr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
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  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un anticorps anti-CD47 et une utilisation associée.
PCT/CN2022/118015 2021-09-13 2022-09-09 Anticorps anti-cd47 et son utilisation WO2023036281A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202111067062.0A CN115785268A (zh) 2021-09-13 2021-09-13 抗cd47抗体及其用途
CN202111067062.0 2021-09-13

Publications (1)

Publication Number Publication Date
WO2023036281A1 true WO2023036281A1 (fr) 2023-03-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/118015 WO2023036281A1 (fr) 2021-09-13 2022-09-09 Anticorps anti-cd47 et son utilisation

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CN (1) CN115785268A (fr)
WO (1) WO2023036281A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116836241A (zh) * 2023-06-09 2023-10-03 湖南中晟全肽生化有限公司 抑制CD47与SIRPα结合的多肽及其应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114075284B (zh) * 2020-08-17 2023-11-17 上海元宋生物技术有限公司 Cd47结合分子及其用途

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107955071A (zh) * 2016-10-18 2018-04-24 上海赛远生物科技有限公司 人源抗人cd47抗体及其编码基因与应用
WO2018075857A1 (fr) * 2016-10-20 2018-04-26 I-Mab Nouveaux anticorps monoclonaux anti-cd 47 et leurs utilisations
CN109438576A (zh) * 2018-11-14 2019-03-08 上海交通大学 一种抗人cd47单克隆抗体的制备及其应用
CN110214154A (zh) * 2017-08-29 2019-09-06 信达生物制药(苏州)有限公司 抗cd47抗体及其用途
CN110305214A (zh) * 2018-03-20 2019-10-08 上海药明生物技术有限公司 新型抗cd47抗体
CN111454359A (zh) * 2020-03-23 2020-07-28 倍而达药业(苏州)有限公司 Cd47抗体或其免疫活性片段及应用
US20200255803A1 (en) * 2017-09-27 2020-08-13 Gracell Biotechnologies (Shanghai) Co., Ltd. Engineered immune cell capable of inducing secretion of anti-cd47 antibody
CN112566662A (zh) * 2018-06-15 2021-03-26 阿库鲁斯生物科学公司 针对cd47的阻断抗体及其使用方法

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107955071A (zh) * 2016-10-18 2018-04-24 上海赛远生物科技有限公司 人源抗人cd47抗体及其编码基因与应用
WO2018075857A1 (fr) * 2016-10-20 2018-04-26 I-Mab Nouveaux anticorps monoclonaux anti-cd 47 et leurs utilisations
CN110214154A (zh) * 2017-08-29 2019-09-06 信达生物制药(苏州)有限公司 抗cd47抗体及其用途
US20200255803A1 (en) * 2017-09-27 2020-08-13 Gracell Biotechnologies (Shanghai) Co., Ltd. Engineered immune cell capable of inducing secretion of anti-cd47 antibody
CN110305214A (zh) * 2018-03-20 2019-10-08 上海药明生物技术有限公司 新型抗cd47抗体
CN112566662A (zh) * 2018-06-15 2021-03-26 阿库鲁斯生物科学公司 针对cd47的阻断抗体及其使用方法
CN109438576A (zh) * 2018-11-14 2019-03-08 上海交通大学 一种抗人cd47单克隆抗体的制备及其应用
CN111454359A (zh) * 2020-03-23 2020-07-28 倍而达药业(苏州)有限公司 Cd47抗体或其免疫活性片段及应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116836241A (zh) * 2023-06-09 2023-10-03 湖南中晟全肽生化有限公司 抑制CD47与SIRPα结合的多肽及其应用
CN116836241B (zh) * 2023-06-09 2024-04-19 湖南中晟全肽生物科技股份有限公司 抑制CD47与SIRPα结合的多肽及其应用

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CN115785268A (zh) 2023-03-14

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