WO2023025182A1 - 一种芳杂环类化合物、含其的药物组合物及其应用 - Google Patents

一种芳杂环类化合物、含其的药物组合物及其应用 Download PDF

Info

Publication number
WO2023025182A1
WO2023025182A1 PCT/CN2022/114443 CN2022114443W WO2023025182A1 WO 2023025182 A1 WO2023025182 A1 WO 2023025182A1 CN 2022114443 W CN2022114443 W CN 2022114443W WO 2023025182 A1 WO2023025182 A1 WO 2023025182A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
composition containing
aromatic heterocyclic
heterocyclic compound
containing same
Prior art date
Application number
PCT/CN2022/114443
Other languages
English (en)
French (fr)
Inventor
何俏军
翁勤洁
陈斌辉
莫俊
聂文文
林庆
葛敏洁
Original Assignee
杭州禹泓医药科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 杭州禹泓医药科技有限公司 filed Critical 杭州禹泓医药科技有限公司
Priority to KR1020247006969A priority Critical patent/KR20240051146A/ko
Priority to AU2022334383A priority patent/AU2022334383A1/en
Priority to CA3228746A priority patent/CA3228746A1/en
Publication of WO2023025182A1 publication Critical patent/WO2023025182A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

本发明公开了一种式I所示化合物及其组合物和应用，其中A，X，Y，L，M和W如本文所定义。本发明公开的化合物可以用于治疗与JAK3激酶过度激活或者过度表达相关的疾病如自身免疫性疾病、肺损伤、器官移植排斥疾病。体外实验表明，该系列化合物具有良好的JAK3激酶抑制活性作用，在医药领域具有良好的应用前景。

Description

无标题
Figure PCTCN2022114443-appb-000001
Figure PCTCN2022114443-appb-000002
Figure PCTCN2022114443-appb-000003
Figure PCTCN2022114443-appb-000004
Figure PCTCN2022114443-appb-000005
Figure PCTCN2022114443-appb-000006
Figure PCTCN2022114443-appb-000007

Claims (1)

  1. Figure PCTCN2022114443-appb-100001
    Figure PCTCN2022114443-appb-100002
    Figure PCTCN2022114443-appb-100003
    Figure PCTCN2022114443-appb-100004
    Figure PCTCN2022114443-appb-100005
    Figure PCTCN2022114443-appb-100006
    Figure PCTCN2022114443-appb-100007
    Figure PCTCN2022114443-appb-100008
    Figure PCTCN2022114443-appb-100009
    Figure PCTCN2022114443-appb-100010
    Figure PCTCN2022114443-appb-100011
    Figure PCTCN2022114443-appb-100012
    Figure PCTCN2022114443-appb-100013
    Figure PCTCN2022114443-appb-100014
    Figure PCTCN2022114443-appb-100015
    Figure PCTCN2022114443-appb-100016
    Figure PCTCN2022114443-appb-100017
    Figure PCTCN2022114443-appb-100018
    Figure PCTCN2022114443-appb-100019
    Figure PCTCN2022114443-appb-100020
    Figure PCTCN2022114443-appb-100021
    Figure PCTCN2022114443-appb-100022
    Figure PCTCN2022114443-appb-100023
    Figure PCTCN2022114443-appb-100024
    Figure PCTCN2022114443-appb-100025
    Figure PCTCN2022114443-appb-100026
    Figure PCTCN2022114443-appb-100027
    Figure PCTCN2022114443-appb-100028
    Figure PCTCN2022114443-appb-100029
    Figure PCTCN2022114443-appb-100030
    Figure PCTCN2022114443-appb-100031
    Figure PCTCN2022114443-appb-100032
    Figure PCTCN2022114443-appb-100033
    Figure PCTCN2022114443-appb-100034
    Figure PCTCN2022114443-appb-100035
    Figure PCTCN2022114443-appb-100036
    Figure PCTCN2022114443-appb-100037
    Figure PCTCN2022114443-appb-100038
    Figure PCTCN2022114443-appb-100039
    Figure PCTCN2022114443-appb-100040
    Figure PCTCN2022114443-appb-100041
    Figure PCTCN2022114443-appb-100042
    Figure PCTCN2022114443-appb-100043
    Figure PCTCN2022114443-appb-100044
    Figure PCTCN2022114443-appb-100045
    Figure PCTCN2022114443-appb-100046
    Figure PCTCN2022114443-appb-100047
PCT/CN2022/114443 2021-08-25 2022-08-24 一种芳杂环类化合物、含其的药物组合物及其应用 WO2023025182A1 (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020247006969A KR20240051146A (ko) 2021-08-25 2022-08-24 방향족 헤테로고리 화합물, 이를 함유한 약물 조성물 및 이의 응용
AU2022334383A AU2022334383A1 (en) 2021-08-25 2022-08-24 Aromatic heterocyclic compound, pharmaceutical composition containing same, and use thereof
CA3228746A CA3228746A1 (en) 2021-08-25 2022-08-24 Aromatic heterocyclic compound, pharmaceutical composition containing the same, and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202110984399 2021-08-25
CN202110984399.1 2021-08-25

Publications (1)

Publication Number Publication Date
WO2023025182A1 true WO2023025182A1 (zh) 2023-03-02

Family

ID=85292830

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/114443 WO2023025182A1 (zh) 2021-08-25 2022-08-24 一种芳杂环类化合物、含其的药物组合物及其应用

Country Status (5)

Country Link
KR (1) KR20240051146A (zh)
CN (3) CN118084939A (zh)
AU (1) AU2022334383A1 (zh)
CA (1) CA3228746A1 (zh)
WO (1) WO2023025182A1 (zh)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013085802A1 (en) * 2011-12-06 2013-06-13 Merck Sharp & Dohme Corp. Pyrrolopyrimidines as janus kinase inhibitors
CN106061973A (zh) * 2013-12-05 2016-10-26 辉瑞公司 吡咯并[2,3‑d]嘧啶基、吡咯并[2,3‑b]吡嗪基和吡咯并[2,3‑d]吡啶基丙烯酰胺
CN106146482A (zh) * 2015-04-14 2016-11-23 宁波文达医药科技有限公司 布鲁顿酪氨酸激酶抑制剂
CN109867676A (zh) * 2017-12-01 2019-06-11 北京普祺医药科技有限公司 一种吡咯并嘧啶衍生的化合物、药物组合物以及其用途
CN112165944A (zh) * 2018-03-29 2021-01-01 德州大学系统董事会 转录激活蛋白的咪唑并哌嗪抑制剂
CN113429427A (zh) * 2021-07-05 2021-09-24 湖南南新制药股份有限公司 杂环化合物及其制备方法和药物用途
WO2021190616A1 (en) * 2020-03-27 2021-09-30 Gritscience Biopharmaceuticals Co., Ltd. Methods for inhibiting casein kinases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115806561A (zh) * 2021-09-14 2023-03-17 南京药石科技股份有限公司 Jak3选择性抑制剂及其用途

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013085802A1 (en) * 2011-12-06 2013-06-13 Merck Sharp & Dohme Corp. Pyrrolopyrimidines as janus kinase inhibitors
CN106061973A (zh) * 2013-12-05 2016-10-26 辉瑞公司 吡咯并[2,3‑d]嘧啶基、吡咯并[2,3‑b]吡嗪基和吡咯并[2,3‑d]吡啶基丙烯酰胺
CN106146482A (zh) * 2015-04-14 2016-11-23 宁波文达医药科技有限公司 布鲁顿酪氨酸激酶抑制剂
CN109867676A (zh) * 2017-12-01 2019-06-11 北京普祺医药科技有限公司 一种吡咯并嘧啶衍生的化合物、药物组合物以及其用途
CN112165944A (zh) * 2018-03-29 2021-01-01 德州大学系统董事会 转录激活蛋白的咪唑并哌嗪抑制剂
WO2021190616A1 (en) * 2020-03-27 2021-09-30 Gritscience Biopharmaceuticals Co., Ltd. Methods for inhibiting casein kinases
CN113429427A (zh) * 2021-07-05 2021-09-24 湖南南新制药股份有限公司 杂环化合物及其制备方法和药物用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ARTHRITIS RHEUMATOL., vol. 72, no. 10, 2020, pages 1621 - 1631

Also Published As

Publication number Publication date
CN115947741B (zh) 2024-05-03
AU2022334383A1 (en) 2024-02-22
CN118084939A (zh) 2024-05-28
CN115724857A (zh) 2023-03-03
KR20240051146A (ko) 2024-04-19
CN115947741A (zh) 2023-04-11
CA3228746A1 (en) 2023-03-02

Similar Documents

Publication Publication Date Title
Carradori et al. Synthesis and cytotoxicity of novel (thiazol-2-yl) hydrazine derivatives as promising anti-Candida agents
CR20200488A (es) Péptidos macrocíclicos contra actinetobacter baumannii
RU2342367C2 (ru) Ненуклеозидные ингибиторы i обратной транскриптазы, предназначенные для лечения заболеваний, опосредованных вич
WO2006067445A3 (en) Csf-1r kinase inhibitors
Aytemir et al. Synthesis and biological activities of new Mannich bases of chlorokojic acid derivatives
Lin et al. Semisynthesis and biological evaluation of xanthone amphiphilics as selective, highly potent antifungal agents to combat fungal resistance
MX2009004908A (es) Compuestos quimicos.
KR20150119037A (ko) 특이한 정벽을 가지는 결정형 및 이 결정형을 유효 성분으로서 함유하는 약학 조성물
EA200501516A1 (ru) Производные 2,3,6-тризамещённого-4-пиримидона
WO2007071963A3 (en) Quinazoline derivatives, process for their preparation and their use as anti-cancer agents
TW200510310A (en) Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient
CN108721265A (zh) 通过给予秋水仙碱衍生物治疗或预防心血管事件
MX2023001997A (es) Compuestos biciclicos, composiciones y usos de los mismos.
PH12021551035A1 (en) Pyrazoles as modulators of hemoglobin
RU2492163C9 (ru) Соединения коричной кислоты (варианты), промежуточные соединения для их получения, фармацевтическая композиция на их основе, способ ингибирования гистоновой деацетилазы, способ лечения диабета, способ лечения опухоли или заболевания, связанного с пролиферацией клеток, способ усиления роста аксонов и способ лечения нейродегенеративных заболеваний и спинной мышечной атрофии
Shah et al. Synthesis and in vitro antimicrobial evaluation of piperazine substituted quinazoline-based thiourea/thiazolidinone/chalcone hybrids
DE602006003224D1 (de) Substituierte heterocyclen, ihre verwendung als medikament und pharmazeutische zubereitungen, die sie enthalten
WO2023025182A1 (zh) 一种芳杂环类化合物、含其的药物组合物及其应用
JP2006527727A5 (zh)
JP2017071623A (ja) Ａｎｔ−リガンド分子および生物学的アプリケ−ション
Yurttaş et al. Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety
Xu et al. Synthesis and decreasing Aβ content evaluation of arctigenin-4-yl carbamate derivatives
Liu et al. Synthesis, biological activities and 3D-QSAR studies of (R)-2-phenyl-4, 5-dihydrothiazole-4-carboxamide derivatives containing a sulfur ether moiety
Yunnikova et al. Synthesis and antimicrobial activity of anilines with 1, 3, 5-cycloheptatriene and 5H-dibenzo [a, d] annulene fragments
Korotkii et al. Synthesis and antimicrobial activity of 1-[4-(1-adamantyl) phenoxy]-3-amino-2-propanol.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22860528

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: AU2022334383

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 3228746

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2022334383

Country of ref document: AU

Date of ref document: 20220824

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 20247006969

Country of ref document: KR

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2022860528

Country of ref document: EP

Effective date: 20240315

NENP Non-entry into the national phase

Ref country code: DE