WO2023018055A1 - Dispositif de diagnostic optique multicanal - Google Patents

Dispositif de diagnostic optique multicanal Download PDF

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Publication number
WO2023018055A1
WO2023018055A1 PCT/KR2022/010736 KR2022010736W WO2023018055A1 WO 2023018055 A1 WO2023018055 A1 WO 2023018055A1 KR 2022010736 W KR2022010736 W KR 2022010736W WO 2023018055 A1 WO2023018055 A1 WO 2023018055A1
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WO
WIPO (PCT)
Prior art keywords
laser light
laser
channel optical
pinhole
diagnostic device
Prior art date
Application number
PCT/KR2022/010736
Other languages
English (en)
Korean (ko)
Inventor
김수경
구자령
이형재
Original Assignee
주식회사 나노바이오라이프
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Application filed by 주식회사 나노바이오라이프 filed Critical 주식회사 나노바이오라이프
Publication of WO2023018055A1 publication Critical patent/WO2023018055A1/fr

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6402Atomic fluorescence; Laser induced fluorescence
    • G01N21/6404Atomic fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/39Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
    • G01N2021/392Measuring reradiation, e.g. fluorescence, backscatter
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/636Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited using an arrangement of pump beam and probe beam; using the measurement of optical non-linear properties
    • G01N2021/637Lasing effect used for analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6463Optics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/06Illumination; Optics
    • G01N2201/061Sources
    • G01N2201/06113Coherent sources; lasers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/06Illumination; Optics
    • G01N2201/064Stray light conditioning
    • G01N2201/0648Shutters

Abstract

La présente invention concerne un dispositif de diagnostic optique multicanal, comprenant : une unité de source de lumière laser qui émet des faisceaux laser de différentes longueurs d'onde ; une lentille de condensation qui concentre les faisceaux laser émis de différentes longueurs d'onde vers un échantillon en cours d'analyse ; un substrat à trous d'épingle qui permet aux faisceaux laser, sélectionnés parmi les faisceaux laser émis de différentes longueurs d'onde qui franchissent la lentille de condensation de le traverser par des trous d'épingle ; une unité de commande qui déplace le substrat à trous d'épingle dans la direction du point focal de la lentille de condensation ; et une unité de détection qui reçoit les faisceaux laser, provenant de l'échantillon en cours d'analyse, qui ont traversé les trous d'épingle.
PCT/KR2022/010736 2021-08-11 2022-07-21 Dispositif de diagnostic optique multicanal WO2023018055A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020210105913A KR102576472B1 (ko) 2021-08-11 2021-08-11 다채널 광학 진단 장치
KR10-2021-0105913 2021-08-11

Publications (1)

Publication Number Publication Date
WO2023018055A1 true WO2023018055A1 (fr) 2023-02-16

Family

ID=85200258

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2022/010736 WO2023018055A1 (fr) 2021-08-11 2022-07-21 Dispositif de diagnostic optique multicanal

Country Status (2)

Country Link
KR (1) KR102576472B1 (fr)
WO (1) WO2023018055A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100495374B1 (ko) * 2002-01-16 2005-06-14 가부시키가이샤 히다치 하이테크놀로지즈 형광, 인광 측정장치
JP2007033381A (ja) * 2005-07-29 2007-02-08 Tokyo Seimitsu Co Ltd 光学式検査装置及びその照明方法
JP2008232742A (ja) * 2007-03-19 2008-10-02 Fujifilm Corp 測定装置
KR101577355B1 (ko) * 2014-09-11 2015-12-14 경북대학교 산학협력단 핀홀 자동 교체 장치, 공간 필터 자동 교체 장치, 공초점 현미경 및 이들의 제조 방법
KR101965803B1 (ko) * 2018-10-30 2019-04-05 나노스코프시스템즈 주식회사 레이저 출력조정기를 가지는 라만 분광기

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0618057D0 (en) 2006-09-14 2006-10-25 Perkinelmer Ltd Improvements in and relating to scanning confocal microscopy
KR20110121497A (ko) * 2010-04-30 2011-11-07 경북대학교 산학협력단 Pzt 스테이지를 이용한 공초점 현미경 시스템 및 그 스캔방법
WO2016125281A1 (fr) 2015-02-05 2016-08-11 株式会社ニコン Microscope à éclairage structuré, procédé d'observation, et programme de commande
KR20190000056A (ko) * 2017-06-22 2019-01-02 (주)노스트 레이저 스캐닝 공초점 현미경

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100495374B1 (ko) * 2002-01-16 2005-06-14 가부시키가이샤 히다치 하이테크놀로지즈 형광, 인광 측정장치
JP2007033381A (ja) * 2005-07-29 2007-02-08 Tokyo Seimitsu Co Ltd 光学式検査装置及びその照明方法
JP2008232742A (ja) * 2007-03-19 2008-10-02 Fujifilm Corp 測定装置
KR101577355B1 (ko) * 2014-09-11 2015-12-14 경북대학교 산학협력단 핀홀 자동 교체 장치, 공간 필터 자동 교체 장치, 공초점 현미경 및 이들의 제조 방법
KR101965803B1 (ko) * 2018-10-30 2019-04-05 나노스코프시스템즈 주식회사 레이저 출력조정기를 가지는 라만 분광기

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Publication number Publication date
KR20230023968A (ko) 2023-02-20
KR102576472B1 (ko) 2023-09-11

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