WO2023018055A1 - Dispositif de diagnostic optique multicanal - Google Patents
Dispositif de diagnostic optique multicanal Download PDFInfo
- Publication number
- WO2023018055A1 WO2023018055A1 PCT/KR2022/010736 KR2022010736W WO2023018055A1 WO 2023018055 A1 WO2023018055 A1 WO 2023018055A1 KR 2022010736 W KR2022010736 W KR 2022010736W WO 2023018055 A1 WO2023018055 A1 WO 2023018055A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- laser light
- laser
- channel optical
- pinhole
- diagnostic device
- Prior art date
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 43
- 239000000758 substrate Substances 0.000 claims abstract description 38
- 238000004458 analytical method Methods 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims description 16
- 230000000903 blocking effect Effects 0.000 claims description 5
- 238000009007 Diagnostic Kit Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 abstract description 4
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 description 28
- 244000005700 microbiome Species 0.000 description 11
- 238000010586 diagram Methods 0.000 description 8
- 230000005540 biological transmission Effects 0.000 description 5
- 239000007850 fluorescent dye Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000012123 point-of-care testing Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 230000010355 oscillation Effects 0.000 description 3
- 230000035899 viability Effects 0.000 description 3
- 239000002033 PVDF binder Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
- 230000001868 lysosomic effect Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6402—Atomic fluorescence; Laser induced fluorescence
- G01N21/6404—Atomic fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
- G01N2021/392—Measuring reradiation, e.g. fluorescence, backscatter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/636—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited using an arrangement of pump beam and probe beam; using the measurement of optical non-linear properties
- G01N2021/637—Lasing effect used for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/064—Stray light conditioning
- G01N2201/0648—Shutters
Abstract
La présente invention concerne un dispositif de diagnostic optique multicanal, comprenant : une unité de source de lumière laser qui émet des faisceaux laser de différentes longueurs d'onde ; une lentille de condensation qui concentre les faisceaux laser émis de différentes longueurs d'onde vers un échantillon en cours d'analyse ; un substrat à trous d'épingle qui permet aux faisceaux laser, sélectionnés parmi les faisceaux laser émis de différentes longueurs d'onde qui franchissent la lentille de condensation de le traverser par des trous d'épingle ; une unité de commande qui déplace le substrat à trous d'épingle dans la direction du point focal de la lentille de condensation ; et une unité de détection qui reçoit les faisceaux laser, provenant de l'échantillon en cours d'analyse, qui ont traversé les trous d'épingle.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020210105913A KR102576472B1 (ko) | 2021-08-11 | 2021-08-11 | 다채널 광학 진단 장치 |
KR10-2021-0105913 | 2021-08-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2023018055A1 true WO2023018055A1 (fr) | 2023-02-16 |
Family
ID=85200258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2022/010736 WO2023018055A1 (fr) | 2021-08-11 | 2022-07-21 | Dispositif de diagnostic optique multicanal |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR102576472B1 (fr) |
WO (1) | WO2023018055A1 (fr) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100495374B1 (ko) * | 2002-01-16 | 2005-06-14 | 가부시키가이샤 히다치 하이테크놀로지즈 | 형광, 인광 측정장치 |
JP2007033381A (ja) * | 2005-07-29 | 2007-02-08 | Tokyo Seimitsu Co Ltd | 光学式検査装置及びその照明方法 |
JP2008232742A (ja) * | 2007-03-19 | 2008-10-02 | Fujifilm Corp | 測定装置 |
KR101577355B1 (ko) * | 2014-09-11 | 2015-12-14 | 경북대학교 산학협력단 | 핀홀 자동 교체 장치, 공간 필터 자동 교체 장치, 공초점 현미경 및 이들의 제조 방법 |
KR101965803B1 (ko) * | 2018-10-30 | 2019-04-05 | 나노스코프시스템즈 주식회사 | 레이저 출력조정기를 가지는 라만 분광기 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0618057D0 (en) | 2006-09-14 | 2006-10-25 | Perkinelmer Ltd | Improvements in and relating to scanning confocal microscopy |
KR20110121497A (ko) * | 2010-04-30 | 2011-11-07 | 경북대학교 산학협력단 | Pzt 스테이지를 이용한 공초점 현미경 시스템 및 그 스캔방법 |
WO2016125281A1 (fr) | 2015-02-05 | 2016-08-11 | 株式会社ニコン | Microscope à éclairage structuré, procédé d'observation, et programme de commande |
KR20190000056A (ko) * | 2017-06-22 | 2019-01-02 | (주)노스트 | 레이저 스캐닝 공초점 현미경 |
-
2021
- 2021-08-11 KR KR1020210105913A patent/KR102576472B1/ko active IP Right Grant
-
2022
- 2022-07-21 WO PCT/KR2022/010736 patent/WO2023018055A1/fr unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100495374B1 (ko) * | 2002-01-16 | 2005-06-14 | 가부시키가이샤 히다치 하이테크놀로지즈 | 형광, 인광 측정장치 |
JP2007033381A (ja) * | 2005-07-29 | 2007-02-08 | Tokyo Seimitsu Co Ltd | 光学式検査装置及びその照明方法 |
JP2008232742A (ja) * | 2007-03-19 | 2008-10-02 | Fujifilm Corp | 測定装置 |
KR101577355B1 (ko) * | 2014-09-11 | 2015-12-14 | 경북대학교 산학협력단 | 핀홀 자동 교체 장치, 공간 필터 자동 교체 장치, 공초점 현미경 및 이들의 제조 방법 |
KR101965803B1 (ko) * | 2018-10-30 | 2019-04-05 | 나노스코프시스템즈 주식회사 | 레이저 출력조정기를 가지는 라만 분광기 |
Also Published As
Publication number | Publication date |
---|---|
KR20230023968A (ko) | 2023-02-20 |
KR102576472B1 (ko) | 2023-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20230358682A1 (en) | Optical signal detection modules and methods | |
US7928408B2 (en) | Multi-channel fluorescence measuring optical system and multi-channel fluorescence sample analyzer | |
EP2376896B1 (fr) | Système optique pour réactions chimiques et/ou biochimiques | |
AU2013202788B2 (en) | Indexing signal detection module | |
US5337139A (en) | Multichannel optical measuring system | |
EA013886B1 (ru) | Система для обнаружения флуоресценции | |
ATE244882T1 (de) | Optisches messsystem zur erfassung von lumineszenz-oder fluoreszenz-signalen | |
ATE472099T1 (de) | Multiplex-fluoreszenzdetektionsvorrichtung mit entfernbaren optischen modulen | |
WO2020067742A1 (fr) | Dispositif de détection de fluorescence d'amplification en chaîne par polymérase, en temps réel | |
CN106085842A (zh) | 一种高通量微流控芯片核酸扩增分析检测系统 | |
EP3218696B1 (fr) | Detecteur diagnostique in vitro portatif et appareil | |
WO2009125974A2 (fr) | Bioréacteur à canaux multiples ayant un détecteur de fluorescence et appareil de surveillance en ligne de celui-ci | |
WO2023018055A1 (fr) | Dispositif de diagnostic optique multicanal | |
WO2013015483A1 (fr) | Lecteur pour analyse d'urine | |
WO2014088249A1 (fr) | Dispositif pour la surveillance d'un biofilm | |
WO2018097458A1 (fr) | Dispositif d'analyse optique utilisant une structure à sources de lumière multiples et son procédé | |
WO2024075934A1 (fr) | Dispositif de mesure optique intégré | |
CN219670501U (zh) | 一种荧光定量pcr仪的检测模块 | |
WO2021201597A1 (fr) | Dispositif de détection de signaux optiques | |
Klotchenko et al. | A Scanning Hardware Analyzer for Recording and Processing Fluorescent Biochip Images | |
CN114276912A (zh) | 荧光检测系统、方法和pcr扩增分析装置 | |
AU2015275317A1 (en) | Indexing signal detection module |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 22856055 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |