WO2023014172A1 - Dispositif de pulvérisation de médicament pour chimiothérapie intrapéritonéale hyperthermique - Google Patents

Dispositif de pulvérisation de médicament pour chimiothérapie intrapéritonéale hyperthermique Download PDF

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Publication number
WO2023014172A1
WO2023014172A1 PCT/KR2022/011668 KR2022011668W WO2023014172A1 WO 2023014172 A1 WO2023014172 A1 WO 2023014172A1 KR 2022011668 W KR2022011668 W KR 2022011668W WO 2023014172 A1 WO2023014172 A1 WO 2023014172A1
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WO
WIPO (PCT)
Prior art keywords
drug
tube
drug injection
holes
abdominal cavity
Prior art date
Application number
PCT/KR2022/011668
Other languages
English (en)
Korean (ko)
Inventor
김희승
유승범
박지원
이은지
박수진
Original Assignee
서울대학교병원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020210103172A external-priority patent/KR102668234B1/ko
Application filed by 서울대학교병원 filed Critical 서울대학교병원
Publication of WO2023014172A1 publication Critical patent/WO2023014172A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3474—Insufflating needles, e.g. Veress needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0059—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1017—Peritoneal cavity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1021—Abdominal cavity

Definitions

  • the present invention relates to a drug injection device for thermal peritoneal chemotherapy.
  • hyperthermic intraperitoneal chemotherapy is used to prevent the tumor from metastasizing to other parts.
  • a tube is inserted into the patient's abdominal cavity and an anticancer drug is sprayed from the tube.
  • Korean Patent Document No. 10-0089183 relates to a thermal perfusion device for preventing peritoneal metastasis after intraperitoneal malignant tumor (cancer) removal surgery, and heat exchange devices connected through inlet and outlet tubes 15 and 17, respectively.
  • a thermal perfusion device for preventing peritoneal metastasis after intraperitoneal malignant tumor (cancer) removal surgery
  • heat exchange devices connected through inlet and outlet tubes 15 and 17, respectively.
  • Korean Patent Publication No. 10-2021-0008990 is an intraperitoneal gas supply system including a two-fluid nozzle, which atomizes an anticancer drug injected at high pressure to a higher level and evenly sprays it into the abdominal cavity. There is no awareness of adjusting the shape of the drug delivery tube to effectively dispense the drug.
  • Patent Document 1 Korea Patent Document No. 10-0089183
  • Patent Document 2 Korean Patent Publication No. 10-2021-0008990
  • the present invention has been made to solve the above problems.
  • the present invention is to effectively inject an anticancer drug into the abdominal cavity of a patient by adjusting the shape of a tube injected into the abdominal cavity and the size and position of an injection hole formed in the tube for thermal anticancer therapy.
  • the anticancer agent in the tube is to prevent the anticancer agent in the tube from being exposed to the outside, including a disinfectant cloth to the outside of the tube.
  • One embodiment of the present invention for solving the above problems is a device located in the patient's abdominal cavity for injecting a drug, the drug injection pipe 100 communicating with the drug reservoir (S); a drug injection tube 200 for dispensing the drug injected through the drug injection tube 100; and a drug discharge pipe 300 that inhales and discharges the drug remaining in the abdominal cavity to the outside of the abdominal cavity and communicates with the drug reservoir S, wherein the drug injection tube 200 includes the drug injection tube.
  • a central tube 210 connected to (100) to receive the drug and extending in the longitudinal direction; and one or more arch tubes 220 connected to the center tube 210 and extending transversely with respect to the center tube 210, each including a plurality of first holes 221; It provides a drug injection device comprising a.
  • the arch tube 220 may be formed to be curved downward.
  • the drug injection tube 200 is connected to the center tube 210, extends away from the center tube 210 based on the longitudinal direction, and then approaches the center tube 210. It may further include a diaphragm tube 230 that is formed to be bent while being extended and includes a plurality of second holes 231 .
  • the plurality of first holes 221 are formed in a spiral shape along the arch tube 220, and the diameter of the plurality of first holes 221 is from the center tube 210 The further away it is, the smaller it can be.
  • the plurality of first holes 221 are located in a spiral shape along the arch tube 220, and the diameter of the plurality of first holes 221 is from the center tube 210
  • the plurality of second holes 231 are spirally located along the diaphragm tube 230, and the diameter of the plurality of second holes 231 is far from the center tube 210. The lower it is, the smaller it can be.
  • the one or more arch tubes 220 may be positioned longitudinally spaced apart from each other.
  • the locking member 500 coupled to the end of the drug injection pipe 100 and including a fixing portion 510; Further, the locking member 500 is positioned between the drug injection pipe 100 and the center tube 210 to fix the drug injection pipe 100 and the center tube 210 to be in communication with each other.
  • a hollow hole 410 is formed, and a disinfectant cloth 400 for sealing a part of the drug injection pipe 100 and the drug discharge pipe 300 from the outside of the abdominal cavity; further comprising, the The center tube 210 extends upward by a certain length and further includes a coupling portion 211 coupled to the locking member 500, and the coupling portion 211 passes through the hollow hole 410 to the locking member. 500, and the locking member 500 may be positioned on the upper side of the disinfectant cloth 400.
  • the shape of a tube injected into the abdominal cavity is similar to the structure of the human body, and a plurality of holes are formed in the tube in a predetermined manner to spray the anticancer drug, so that the entire inside of the patient's abdominal cavity can be sprayed.
  • Anticancer drugs can be sprayed evenly.
  • the location of the spray hole formed in the tube is spirally positioned, and the size and position of the spray hole are hydrodynamically adjusted so that the anticancer drug can be more evenly sprayed throughout the abdominal cavity of the patient. Accordingly, the effect of further increasing the anticancer drug response rate after tumor surgery is exerted.
  • FIG. 1 is a view for explaining a drug injection device according to the present invention.
  • FIG. 2 is a view for explaining a drug injection tube according to the present invention.
  • FIG. 3 is a view for explaining that the drug injection device according to the present invention is installed in the abdominal cavity.
  • FIG. 4 is a view for explaining the flow of the anticancer agent injected from the drug injection device according to the present invention.
  • 5 and 6 are views for explaining the locking member and the disinfectant cloth according to the present invention.
  • the drug injection device includes a drug injection pipe 100, a drug injection tube 200 and a drug discharge pipe 300.
  • the drug injection tube 100 is connected to the drug supply tube S located outside the body and injects the drug into the drug injection tube 200 located inside the body.
  • a pump P is installed inside the drug supply container S to provide a pumping force for drug injection into the drug injection tube 100 .
  • the pump P is formed on one side of the drug injection pipe 100 to pump the drug flowing into the drug injection pipe 100, but flows from the drug supply pipe S to the drug injection pipe 100.
  • it is a means that can easily deliver the drug to be, it is not limited thereto.
  • the drug supply tube (S) communicates with the drug discharge pipe 300 to be described later, and may collect the remaining drug after spraying the drug into the abdominal cavity again.
  • the drug supply container (S) is formed so that a space communicating with the drug injection pipe 100 and a space communicating with the drug discharge pipe 300 are separated, so that the drug to be injected into the patient and the drug collected from the patient can be separated separately. there is.
  • the portion of the drug supply cylinder S communicating with the drug discharge pipe 300 may be filtered through a separate treatment or filter and reused for re-injection of the drug through the drug injection pipe 100 in the future.
  • the drug injection tube 100 is connected to one side of the center tube 210 to be described later, and injects the drug into the center tube 210.
  • the drug injection tube 100 may be connected to a coupling part 211 of the center tube 210 to be described later.
  • the drug injection tube 100 is not limited to the illustrated position and shape.
  • the drug injection tube 200 receives the drug from the drug injection tube 100 and injects the drug into the patient's abdominal cavity.
  • the drug dispensing tube 200 includes a central tube 210 and an arch tube 220.
  • the central tube 210 is connected to the drug injection tube 100 to receive the drug, and extends in the longitudinal direction based on the lying patient.
  • the central tube 210 may deliver the drug to the arch tube 220 described below.
  • the center tube 210 may include a coupling part 211 and be connected to the drug injection pipe 100, and a locking member 500 described later may be positioned and fixed at a portion connected to the drug injection pipe 100. there is.
  • the coupling part 211 may be formed by extending upward by a predetermined length from the central tube 210, but is not limited to a specific length or shape as long as it is a structure that can be connected to the drug injection tube 100.
  • the arch tube 220 is connected to the center tube 210 and extends in a transverse direction relative to the center tube 210 .
  • the arch tube 220 may extend from the center tube 210 and be bent downward.
  • the arch tube 220 may be formed in an arch shape, and may be formed to correspond to the shape of the ribs of the patient, so that it is ergonomically designed and positioned more closely to the internal organs of the abdominal cavity. Compared to a technique in which the injection tube 100 is inserted into the body to inject the drug, it has the advantage of evenly injecting the drug into the internal organs of the abdominal cavity.
  • the arch tube 220 may extend horizontally from the side of the center tube 210 to the left and right, respectively, but is not limited thereto.
  • the arch tube 220 may be connected to the lower side of the center tube 210 and integrally formed with the center tube 210 .
  • the length of the central tube 210 may be formed to match the average length of the abdominal cavity of the patient.
  • the curvature of the arch tube 220 may be constant, but is not limited thereto, and is not limited to the curvature of the illustrated arch tube 220 .
  • the arch tube 220 is connected to the center tube 210, and may be positioned in a plurality at a predetermined interval in the longitudinal direction.
  • the predetermined interval at which the arch tubes 220 are spaced apart is not limited to the illustrated bar, and the number of the arch tubes 220 is not limited to the illustrated bar.
  • the arch tube 220 is supplied with medication from the central tube 210 .
  • the arch tube 220 may be formed with a plurality of first holes 221 to inject the supplied drug.
  • the plurality of first holes 221 are located in a spiral of the arch tube 220 along the arch tube 220 . That is, connecting the centers of each of the plurality of first holes 221 means that they are spaced apart in a spiral manner.
  • the drug can be discharged in various directions along the arch tube 220, and accordingly, the drug can be evenly sprayed to the organs in the abdominal cavity.
  • the direction in which the plurality of first holes 221 spirally rotate is not limited to the illustrated bar.
  • the diameters of the plurality of first holes 221 are formed to be smaller as they are further away from the center tube 210 . That is, the diameter of each first hole 221 is formed to be larger in the upper side in the height direction of the arch tube 220 .
  • the flow rate of the fluid decreases as it moves away from the pump P, which provides power for fluid injection.
  • the flow rate in the first hole 221 close to the tube 210 may be reduced, and the flow rate in the first hole 221 far from the center tube 210 may be increased. Accordingly, regardless of the degree of separation from the drug injection tube 100, the amount of the injected drug may be uniformly injected.
  • first hole 221 formed in each arch tube 220 may have a different diameter according to a distance away from the center tube 210 .
  • the arch tube 220 with a large distance from the center tube 210 has each first hole 221 at the same height as the arch tube 220 with a small distance from the center tube 210. Even if located, the diameter of the first hole 221 may be formed to be larger.
  • the direction in which the drug is injected from the first hole 221 and the second hole 231 to be described later is not limited to the illustrated bar.
  • the drug injection tube 200 may further include a diaphragm tube 230.
  • the diaphragm tube 230 is connected to the central tube 210 and may be positioned upward, more than the arch tube 220 .
  • the diaphragm tube 230 is formed to be bent so as to extend away from the center tube 210 based on the longitudinal direction and then extend again to approach the center tube 210 .
  • the diaphragm tube 230 may be formed to correspond to the shape of the patient's diaphragm, and it is possible to evenly inject the drug into the abdominal cavity around the diaphragm.
  • the diaphragmatic tube 230 receives the drug from the central tube 210.
  • a plurality of second holes 231 may be formed in the diaphragm tube 230 to inject the drug.
  • the second hole 231 formed in the diaphragm tube 230 is spirally positioned to uniformly inject the drug into the abdominal cavity.
  • the drug includes an anticancer agent
  • the antiseptic cloth 400 may be positioned to seal a portion of the drug injection pipe 100 and the drug discharge pipe 300 from the outside of the abdominal cavity.
  • the drug injection tube 100, the drug injection tube 200, and the drug discharge tube 300 may be wrapped and separated from the abdominal cavity by using the antiseptic cloth 400.
  • the disinfectant cloth 400 is formed of a material that can be folded or crumpled, and the shape of the disinfectant cloth 400 is not limited to the bar shown.
  • the locking member 500 suffices if it is used to fix the drug injection tube 200, and the fixing method and structure thereof are not limited to a specific method.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif de pulvérisation de médicament pour chimiothérapie intrapéritonéale hyperthermique.
PCT/KR2022/011668 2021-08-05 2022-08-05 Dispositif de pulvérisation de médicament pour chimiothérapie intrapéritonéale hyperthermique WO2023014172A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020210103172A KR102668234B1 (ko) 2021-08-05 온열복강항암치료를 위한 약물 분사 장치
KR10-2021-0103172 2021-08-05

Publications (1)

Publication Number Publication Date
WO2023014172A1 true WO2023014172A1 (fr) 2023-02-09

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Application Number Title Priority Date Filing Date
PCT/KR2022/011668 WO2023014172A1 (fr) 2021-08-05 2022-08-05 Dispositif de pulvérisation de médicament pour chimiothérapie intrapéritonéale hyperthermique

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WO (1) WO2023014172A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010049500A1 (en) * 1999-07-14 2001-12-06 Vantassel Robert A. Catheter for drug injection in cardiovascular system
US20160101228A1 (en) * 2014-10-14 2016-04-14 John J. Landy, III Method and system providing more accurate fluid temperature monitoring with selectable fluid input and output arragements for body cavity treatments
JP2019088422A (ja) * 2017-11-14 2019-06-13 花田　卓蔵 温熱治療装置
KR20210008989A (ko) * 2019-07-15 2021-01-26 서울대학교병원 복강 내 온열 가압 가스 순환 시스템

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010049500A1 (en) * 1999-07-14 2001-12-06 Vantassel Robert A. Catheter for drug injection in cardiovascular system
US20160101228A1 (en) * 2014-10-14 2016-04-14 John J. Landy, III Method and system providing more accurate fluid temperature monitoring with selectable fluid input and output arragements for body cavity treatments
JP2019088422A (ja) * 2017-11-14 2019-06-13 花田　卓蔵 温熱治療装置
KR20210008989A (ko) * 2019-07-15 2021-01-26 서울대학교병원 복강 내 온열 가압 가스 순환 시스템

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MIKKELSEN METTE SCHOU, BLAAKAER JAN, PETERSEN LONE KJELD, SCHLEISS LUISE GRAM, IVERSEN LENE HJERRILD: "Pharmacokinetics and toxicity of carboplatin used for hyperthermic intraperitoneal chemotherapy (HIPEC) in treatment of epithelial ovarian cancer", PLEURA AND PERITONEUM, vol. 5, no. 4, pages 20200137, XP093032336, DOI: 10.1515/pp_2020-0137 *

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Publication number Publication date
KR20230021373A (ko) 2023-02-14

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