WO2023014172A1

WO2023014172A1 - Drug spray device for hyperthermic intraperitoneal chemotherapy

Info

Publication number: WO2023014172A1
Application number: PCT/KR2022/011668
Authority: WO
Inventors: 김희승; 유승범; 박지원; 이은지; 박수진
Original assignee: 서울대학교병원
Priority date: 2021-08-05
Filing date: 2022-08-05
Publication date: 2023-02-09
Also published as: KR20230021373A

Abstract

The present invention relates to a drug spray device for hyperthermic intraperitoneal chemotherapy.

Description

Drug dispensing device for thermal celiac chemotherapy

The present invention relates to a drug injection device for thermal peritoneal chemotherapy.

After removing a malignant tumor (cancer) in the abdominal cavity, hyperthermic intraperitoneal chemotherapy (HIPEC) is used to prevent the tumor from metastasizing to other parts.

In thermal peritoneal chemotherapy, a tube is inserted into the patient's abdominal cavity and an anticancer drug is sprayed from the tube.

However, in the prior art, a tube inserted into the abdominal cavity for thermal celiac chemotherapy was formed as a Y-tube, and the drug was injected and flowed from the upper side of the abdominal cavity using this method. This has a problem in that it is difficult to spray the anticancer agent evenly into the abdominal cavity.

For example, Korean Patent Document No. 10-0089183 relates to a thermal perfusion device for preventing peritoneal metastasis after intraperitoneal malignant tumor (cancer) removal surgery, and heat exchange devices connected through inlet and outlet tubes 15 and 17, respectively. There is no technology for injecting an anticancer drug into the abdominal cavity including the device 12, or awareness for effectively dispensing the drug by configuring the inlet and outlet tubes 15 and 17 as a Y-tube, so the problem that the drug is not evenly sprayed there was.

For another example, Korean Patent Publication No. 10-2021-0008990 is an intraperitoneal gas supply system including a two-fluid nozzle, which atomizes an anticancer drug injected at high pressure to a higher level and evenly sprays it into the abdominal cavity. There is no awareness of adjusting the shape of the drug delivery tube to effectively dispense the drug.

(Patent Document 1) Korea Patent Document No. 10-0089183

(Patent Document 2) Korean Patent Publication No. 10-2021-0008990

The present invention has been made to solve the above problems.

Specifically, the present invention is to effectively inject an anticancer drug into the abdominal cavity of a patient by adjusting the shape of a tube injected into the abdominal cavity and the size and position of an injection hole formed in the tube for thermal anticancer therapy.

In addition, it is to prevent the anticancer agent in the tube from being exposed to the outside, including a disinfectant cloth to the outside of the tube.

In addition, it is to secure the tube safely, including a locking member capable of fixing the tube.

One embodiment of the present invention for solving the above problems is a device located in the patient's abdominal cavity for injecting a drug, the drug injection pipe 100 communicating with the drug reservoir (S); a drug injection tube 200 for dispensing the drug injected through the drug injection tube 100; and a drug discharge pipe 300 that inhales and discharges the drug remaining in the abdominal cavity to the outside of the abdominal cavity and communicates with the drug reservoir S, wherein the drug injection tube 200 includes the drug injection tube. A central tube 210 connected to (100) to receive the drug and extending in the longitudinal direction; and one or more arch tubes 220 connected to the center tube 210 and extending transversely with respect to the center tube 210, each including a plurality of first holes 221; It provides a drug injection device comprising a.

In one embodiment, the arch tube 220 may be formed to be curved downward.

In one embodiment, the drug injection tube 200 is connected to the center tube 210, extends away from the center tube 210 based on the longitudinal direction, and then approaches the center tube 210. It may further include a diaphragm tube 230 that is formed to be bent while being extended and includes a plurality of second holes 231 .

In one embodiment, the plurality of first holes 221 are formed in a spiral shape along the arch tube 220, and the diameter of the plurality of first holes 221 is from the center tube 210 The further away it is, the smaller it can be.

In one embodiment, the plurality of first holes 221 are located in a spiral shape along the arch tube 220, and the diameter of the plurality of first holes 221 is from the center tube 210 The plurality of second holes 231 are spirally located along the diaphragm tube 230, and the diameter of the plurality of second holes 231 is far from the center tube 210. The lower it is, the smaller it can be.

In one embodiment, the one or more arch tubes 220 may be positioned longitudinally spaced apart from each other.

In one embodiment, the locking member 500 coupled to the end of the drug injection pipe 100 and including a fixing portion 510; Further, the locking member 500 is positioned between the drug injection pipe 100 and the center tube 210 to fix the drug injection pipe 100 and the center tube 210 to be in communication with each other. can

In one embodiment, a hollow hole 410 is formed, and a disinfectant cloth 400 for sealing a part of the drug injection pipe 100 and the drug discharge pipe 300 from the outside of the abdominal cavity; further comprising, the The center tube 210 extends upward by a certain length and further includes a coupling portion 211 coupled to the locking member 500, and the coupling portion 211 passes through the hollow hole 410 to the locking member. 500, and the locking member 500 may be positioned on the upper side of the disinfectant cloth 400.

According to the present invention, the following effects are achieved.

According to the present invention, for thermal anticancer treatment, the shape of a tube injected into the abdominal cavity is similar to the structure of the human body, and a plurality of holes are formed in the tube in a predetermined manner to spray the anticancer drug, so that the entire inside of the patient's abdominal cavity can be sprayed. Anticancer drugs can be sprayed evenly.

In addition, the location of the spray hole formed in the tube is spirally positioned, and the size and position of the spray hole are hydrodynamically adjusted so that the anticancer drug can be more evenly sprayed throughout the abdominal cavity of the patient. Accordingly, the effect of further increasing the anticancer drug response rate after tumor surgery is exerted.

In addition, by including an antiseptic cloth to the outside of the tube, the effect of preventing the anticancer agent from being exposed to the outside is achieved.

In addition, including a locking member capable of fixing the tube, the effect of safely fixing the tube is achieved.

1 is a view for explaining a drug injection device according to the present invention.

2 is a view for explaining a drug injection tube according to the present invention.

3 is a view for explaining that the drug injection device according to the present invention is installed in the abdominal cavity.

4 is a view for explaining the flow of the anticancer agent injected from the drug injection device according to the present invention.

5 and 6 are views for explaining the locking member and the disinfectant cloth according to the present invention.

In some cases, in order to avoid obscuring the concept of the present invention, well-known structures and devices may be omitted or may be shown in block diagram form centering on core functions of each structure and device.

In addition, in describing the embodiments of the present invention, if it is determined that a detailed description of a known function or configuration may unnecessarily obscure the subject matter of the present invention, the detailed description will be omitted. In addition, terms to be described later are terms defined in consideration of functions in the embodiment of the present invention, which may vary according to the intention or custom of a user or operator. Therefore, the definition should be made based on the contents throughout this specification.

The drug injection device according to the present invention includes a drug injection pipe 100, a drug injection tube 200 and a drug discharge pipe 300.

Referring to Figures 1 to 4, the drug injection device according to the present invention will be described.

The drug injection tube 100 is connected to the drug supply tube S located outside the body and injects the drug into the drug injection tube 200 located inside the body.

A pump P is installed inside the drug supply container S to provide a pumping force for drug injection into the drug injection tube 100 .

At this time, the pump P is formed on one side of the drug injection pipe 100 to pump the drug flowing into the drug injection pipe 100, but flows from the drug supply pipe S to the drug injection pipe 100. As long as it is a means that can easily deliver the drug to be, it is not limited thereto.

The drug supply tube (S) communicates with the drug discharge pipe 300 to be described later, and may collect the remaining drug after spraying the drug into the abdominal cavity again.

The drug supply container (S) is formed so that a space communicating with the drug injection pipe 100 and a space communicating with the drug discharge pipe 300 are separated, so that the drug to be injected into the patient and the drug collected from the patient can be separated separately. there is.

At this time, the portion of the drug supply cylinder S communicating with the drug discharge pipe 300 may be filtered through a separate treatment or filter and reused for re-injection of the drug through the drug injection pipe 100 in the future.

Accordingly, it has an advantage that it is possible to treat a drug injection target with a small amount of drug while maintaining hygiene and efficacy of the drug to be injected into the patient.

The drug injection tube 100 is connected to one side of the center tube 210 to be described later, and injects the drug into the center tube 210.

At this time, the drug injection tube 100 may be connected to a coupling part 211 of the center tube 210 to be described later.

At this time, the drug injection tube 100 is not limited to the illustrated position and shape.

The drug injection tube 200 receives the drug from the drug injection tube 100 and injects the drug into the patient's abdominal cavity.

The drug dispensing tube 200 includes a central tube 210 and an arch tube 220.

The central tube 210 is connected to the drug injection tube 100 to receive the drug, and extends in the longitudinal direction based on the lying patient.

The central tube 210 may deliver the drug to the arch tube 220 described below.

The center tube 210 may include a coupling part 211 and be connected to the drug injection pipe 100, and a locking member 500 described later may be positioned and fixed at a portion connected to the drug injection pipe 100. there is.

The coupling part 211 may be formed by extending upward by a predetermined length from the central tube 210, but is not limited to a specific length or shape as long as it is a structure that can be connected to the drug injection tube 100.

The arch tube 220 is connected to the center tube 210 and extends in a transverse direction relative to the center tube 210 . In addition, the arch tube 220 may extend from the center tube 210 and be bent downward.

Accordingly, the arch tube 220 may be formed in an arch shape, and may be formed to correspond to the shape of the ribs of the patient, so that it is ergonomically designed and positioned more closely to the internal organs of the abdominal cavity. Compared to a technique in which the injection tube 100 is inserted into the body to inject the drug, it has the advantage of evenly injecting the drug into the internal organs of the abdominal cavity.

At this time, the way in which the arch tube 220 is connected to the center tube 210, the arch tube 220 may extend horizontally from the side of the center tube 210 to the left and right, respectively, but is not limited thereto. For example, the arch tube 220 may be connected to the lower side of the center tube 210 and integrally formed with the center tube 210 .

At this time, the length of the central tube 210 may be formed to match the average length of the abdominal cavity of the patient.

At this time, the curvature of the arch tube 220 may be constant, but is not limited thereto, and is not limited to the curvature of the illustrated arch tube 220 .

In addition, the arch tube 220 is connected to the center tube 210, and may be positioned in a plurality at a predetermined interval in the longitudinal direction.

At this time, the predetermined interval at which the arch tubes 220 are spaced apart is not limited to the illustrated bar, and the number of the arch tubes 220 is not limited to the illustrated bar.

The arch tube 220 is supplied with medication from the central tube 210 .

The arch tube 220 may be formed with a plurality of first holes 221 to inject the supplied drug.

The plurality of first holes 221 are located in a spiral of the arch tube 220 along the arch tube 220 . That is, connecting the centers of each of the plurality of first holes 221 means that they are spaced apart in a spiral manner.

Since the plurality of first holes 221 are spirally positioned, the drug can be discharged in various directions along the arch tube 220, and accordingly, the drug can be evenly sprayed to the organs in the abdominal cavity.

At this time, the direction in which the plurality of first holes 221 spirally rotate is not limited to the illustrated bar.

Also, the diameters of the plurality of first holes 221 are formed to be smaller as they are further away from the center tube 210 . That is, the diameter of each first hole 221 is formed to be larger in the upper side in the height direction of the arch tube 220 .

Hydrodynamically, the flow rate of the fluid decreases as it moves away from the pump P, which provides power for fluid injection. The flow rate in the first hole 221 close to the tube 210 may be reduced, and the flow rate in the first hole 221 far from the center tube 210 may be increased. Accordingly, regardless of the degree of separation from the drug injection tube 100, the amount of the injected drug may be uniformly injected.

In addition, the first hole 221 formed in each arch tube 220 may have a different diameter according to a distance away from the center tube 210 . For example, the arch tube 220 with a large distance from the center tube 210 has each first hole 221 at the same height as the arch tube 220 with a small distance from the center tube 210. Even if located, the diameter of the first hole 221 may be formed to be larger.

At this time, the direction in which the drug is injected from the first hole 221 and the second hole 231 to be described later is not limited to the illustrated bar.

In addition, the drug injection tube 200 may further include a diaphragm tube 230.

The diaphragm tube 230 is connected to the central tube 210 and may be positioned upward, more than the arch tube 220 .

The diaphragm tube 230 is formed to be bent so as to extend away from the center tube 210 based on the longitudinal direction and then extend again to approach the center tube 210 .

Accordingly, the diaphragm tube 230 may be formed to correspond to the shape of the patient's diaphragm, and it is possible to evenly inject the drug into the abdominal cavity around the diaphragm.

The diaphragmatic tube 230 receives the drug from the central tube 210.

A plurality of second holes 231 may be formed in the diaphragm tube 230 to inject the drug.

Like the first hole 221 described above, the second hole 231 formed in the diaphragm tube 230 is spirally positioned to uniformly inject the drug into the abdominal cavity.

In addition, the second hole 231 formed in the diaphragm tube 230, like the first hole 221 described above, regardless of the distance from the center tube 210 to be injected, the amount of injected drug is constant The diameter of the second hole 231 for spraying is formed to be smaller as the distance from the center tube 210 increases.

The second hole 231 formed in the diaphragm tube 230 is formed to include the characteristics of the above-described first hole 221, and a detailed description thereof will be omitted.

The drug discharge pipe 300 is not directly connected to the drug injection tube 200, but sucks in the drug remaining in the abdominal cavity after being injected from the drug injection tube 200 and discharges the drug to the outside of the abdominal cavity. As described above, the drug discharge pipe 300 communicates with the drug reservoir S.

One end of the drug discharge tube 300 is inserted into the abdominal cavity, sprayed into the abdominal cavity, absorbed by organs in the abdominal cavity, etc., and then the remaining drug can be discharged to the outside of the abdominal cavity, such as the drug reservoir (S), but its location is shown It is not limited to what has been done.

The drug discharge pipe 300 may be located on both left and right sides of the abdominal cavity, and may discharge the drug remaining in the abdominal cavity to the outside of the abdominal cavity.

In addition, the drug spraying device according to the present invention may further include a disinfectant cloth 400.

After dispensing the drug through the drug dispensing tube 200, in the process of recovering the drug to the drug reservoir S through the drug discharge pipe 300 and in the process of separating the patient and the drug dispensing tube 200, the drug is released into the outside air. may be exposed in

Since the drug includes an anticancer agent, in the present invention, it is possible to secure the safety of the medical staff by further providing a disinfectant cloth 400 to prevent the drug from leaking into the air.

In the present invention, the antiseptic cloth 400 is positioned to seal a portion of the drug injection pipe 100 and the drug discharge pipe 300 from the outside of the abdominal cavity, so that the drug can be prevented from being exposed to the outside air.

Referring to FIG. 5 , the antiseptic cloth 400 may be positioned to seal a portion of the drug injection pipe 100 and the drug discharge pipe 300 from the outside of the abdominal cavity.

The disinfectant cloth 400 may further include a hollow hole 410.

The coupling portion 211 may pass through the hollow hole 410 , and the coupling portion 211 and the drug injection tube 100 may be fixed by the locking member 500 .

In addition, the drug injection tube 100, the drug injection tube 200, and the drug discharge tube 300 may be wrapped and separated from the abdominal cavity by using the antiseptic cloth 400.

The antiseptic cloth 400 can be separated while wrapping the drug injection tube 100, the drug injection tube 200, and the drug discharge tube 300, which not only facilitates separation but also prevents exposure of residual drugs to the outside air. There are effects that can be done.

At this time, the disinfectant cloth 400 is formed of a material that can be folded or crumpled, and the shape of the disinfectant cloth 400 is not limited to the bar shown.

In addition, the drug injection device according to the present invention may further include a locking member 500.

The locking member 500 may be positioned at a joint between the drug injection tube 100 and the central tube 210 to fix the drug injection tube 220 .

In addition, the locking member 500 has an effect of sealing the disinfectant cloth 400 to the upper side of the hollow hole 410. Accordingly, there is also an effect of doubly preventing exposure of the drug to the outside air.

Referring to Figure 6, the locking member 500 is shown coupled to the end of the drug injection tube (100).

The locking member 500 is coupled to the distal end of the drug injection tube 100, and may be positioned at a joint between the drug injection tube 100 and the central tube 210.

The locking member 500 is coupled to the end of the drug injection tube 100, so that the drug injection tube 100 is fixed and connected to the drug injection tube 220, the inside of the locking member 500 is drug injection A hollow hole may be formed to allow the tube 100 to pass therethrough.

In addition, the locking member 500 includes a fixing part 510 and is formed so that the drug injection tube 100 and the central tube 210 can be completely fixed, thereby further preventing the drug from leaking to the outside. .

The fixing part 510 is a part formed to be located on the outside of the locking member 500 to tighten the locking member 500, but is not limited to a specific structure, and the locking member 500 is located at the center of the drug injection tube 100 It is sufficient if the tube 210 is formed to be fixed.

In addition, the locking member 500 is not limited to the illustrated position, and may be further positioned in a portion where the drug may leak.

At this time, the locking member 500 suffices if it is used to fix the drug injection tube 200, and the fixing method and structure thereof are not limited to a specific method.

In the above, the present specification has been described with reference to the embodiments shown in the drawings so that those skilled in the art can easily understand and reproduce the present invention, but this is only exemplary, and those skilled in the art can make various modifications and equivalents from the embodiments of the present invention. It will be appreciated that embodiments are possible. Therefore, the scope of protection of the present invention should be defined by the claims.

(Description of code)

100: drug injection tube

200: drug injection tube

210: center tube

211: coupling part

220: arch tube

221: first hole

230: diaphragm tube

231: second hole

300: drug discharge pipe

400: disinfectant cloth

410: hollow hole

500: locking member

510: fixing part

S: drug reservoir

P: Pump

Claims

A device that is located in the patient's abdominal cavity and injects a drug,

A drug injection pipe 100 communicating with the drug reservoir (S);

a drug injection tube 200 for dispensing the drug injected through the drug injection tube 100; and

Including; a drug discharge pipe 300 inhaling and discharging the drug remaining in the abdominal cavity to the outside of the abdominal cavity and communicating with the drug reservoir (S),

The drug injection tube 200,

a central tube 210 connected to the drug injection tube 100 to receive drug injection and extending in a longitudinal direction; and

one or more arch tubes 220 connected to the center tube 210, extending transversely with respect to the center tube 210, and each including a plurality of first holes 221; including,

drug dispensing device.
According to claim 1,

The arch tube 220 is formed to be bent toward the lower side,

drug dispensing device.
According to claim 2,

The drug injection tube 200,

It is connected to the center tube 210, extends away from the center tube 210 based on the longitudinal direction, and is formed to be bent so as to extend toward the center tube 210, and a plurality of second holes 231 Further comprising; a diaphragm tube 230 comprising a)

drug dispensing device.
According to claim 2,

The plurality of first holes 221 are formed in a spiral shape along the arch tube 220,

The diameters of the plurality of first holes 221 are smaller as they are further away from the center tube 210,

drug dispensing device.
According to claim 3,

The plurality of first holes 221 are spirally positioned along the arch tube 220,

The diameters of the plurality of first holes 221 are smaller as they are further away from the center tube 210,

The plurality of second holes 231 are spirally positioned along the diaphragm tube 230,

The diameters of the plurality of second holes 231 are smaller as they are further away from the center tube 210,

drug dispensing device.
According to claim 1,

The one or more arch tubes 220 are positioned to be longitudinally spaced apart from each other,

drug dispensing device.
According to claim 1,

A locking member 500 coupled to an end of the drug injection tube 100 and including a fixing part 510; Including more,

The locking member 500 is positioned between the drug injection tube 100 and the center tube 210 to fix the drug injection tube 100 and the center tube 210 to communicate with each other,

drug dispensing device.
According to claim 7,

A hollow hole 410 is formed, and a disinfectant cloth 400 for sealing a part of the drug injection pipe 100 and the drug discharge pipe 300 from the outside of the abdominal cavity; further comprising,

The center tube 210 further includes a coupling part 211 extending a certain length upward and coupled to the locking member 500,

The coupling part 211 passes through the hollow hole 410 and is coupled to the locking member 500, and the locking member 500 is positioned above the disinfectant cloth 400,

drug dispensing device.