WO2015037832A1 - Capillary device comprising internal filter, and injection fluid injection device comprising same - Google Patents

Capillary device comprising internal filter, and injection fluid injection device comprising same Download PDF

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Publication number
WO2015037832A1
WO2015037832A1 PCT/KR2014/007421 KR2014007421W WO2015037832A1 WO 2015037832 A1 WO2015037832 A1 WO 2015037832A1 KR 2014007421 W KR2014007421 W KR 2014007421W WO 2015037832 A1 WO2015037832 A1 WO 2015037832A1
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WO
WIPO (PCT)
Prior art keywords
capillary
liquid
filter
body portion
coupling body
Prior art date
Application number
PCT/KR2014/007421
Other languages
French (fr)
Korean (ko)
Inventor
김용무
Original Assignee
Kim Young Mu
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Filing date
Publication date
Application filed by Kim Young Mu filed Critical Kim Young Mu
Publication of WO2015037832A1 publication Critical patent/WO2015037832A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/141—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor with capillaries for restricting fluid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A61M5/38—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body using hydrophilic or hydrophobic filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids
    • A61M2005/1652—Filter with duct, e.g. filtering element incorporated in a flow line, tube, duct
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7527—General characteristics of the apparatus with filters liquophilic, hydrophilic

Definitions

  • the present invention relates to a capillary device having an internal filter, and more particularly, to effectively remove various impurities that may be contained in the liquid flowing to the capillary even after primary filtration by an external filter device provided in the liquid supply line.
  • the present invention relates to a capillary device having an internal filter which prevents the capillary from clogging or narrowing so that the flow of liquid stops or the flow rate is slowed down.
  • the present invention relates to a capillary device having an internal filter having a function of preventing foreign matter from entering the liquid by scratching the inside of the capillary device by the sharp edge of the capillary when the capillary is inserted into the capillary device. .
  • the present invention relates to an injection liquid injection device comprising a capillary device with such an internal filter.
  • the injection liquid injection device In general, patients often need to be constantly injected with injections. At this time, the injection liquid injection device is used, the injection liquid injection device includes a filter device for removing foreign matter and air contained in the injection liquid.
  • a conventional injection liquid injecting apparatus includes an injection liquid storage means such as a bottle or a pack in which an injection liquid is stored, and a flexible extension tube which is provided to extend from the injection liquid storage means and in which the injection liquid supplied from the injection liquid storage means is transferred. Equipped.
  • the extension tube is provided with an external filter device for filtering and removing foreign substances and air in the supplied injection liquid, and the terminal end of the extension tube is detachably coupled to the needle or catheter inserted into the patient's body.
  • the injection liquid stored in the injection liquid storage means is discharged and supplied in small portions to flow along the extension tube, and finally, the needle or catheter coupled to the terminal connector Through the patient's body.
  • an external filter device having a hydrophobic filter and a friend filter is provided on the path of the extension tube, and finally, the end of the extension tube connected to the external filter device controls the flow rate of the drug.
  • Capillary tube is provided. Capillaries placed inside the distal ends of extension tubes prevent excessive injection of drugs that can cause fatal damage to the patient's organs at high rates of drug injection, such as anticancer drugs or antibiotics.
  • the conventional filter device is required to adopt a plurality of filter materials to completely remove the air and solid impurities contained in the drug, which is due to the structural complexity, the assembly is complicated and the manufacturing cost increases There was this.
  • the conventional filter device employing a plurality of filter materials for the complete removal of air and solid impurities not only has a problem of slowing the flow rate of the drug to be injected into the patient at a constant rate, There was an unsatisfactory problem in terms of the effect of removal.
  • the present inventor has proposed a novel configuration of the filter device and the injection liquid injection device having the same.
  • These new devices are designed to effectively remove solid impurities such as air and glass chips in the drug. Examples of such new devices are disclosed in WO 2007/117119 A1 and Korean Patent Publication No. 10-2008-0104487.
  • the filter devices and the injection liquid injection device including the same are excellent technologies, the continuous improvement can be made like other excellent technologies.
  • a conventional external filter device may primarily filter impurities such as particles contained in a liquid such as a drug and solid particles such as precipitates newly generated in a flowing drug.
  • impurities such as particles contained in a liquid such as a drug
  • solid particles such as precipitates newly generated in a flowing drug.
  • the external filter device when the first filtered drug passes through the extension tube connected to the external filter device to the capillary tube, which controls the flow rate, impurities that may exist inside the extension tube, the external The drug may be contaminated again by the adhesive component used to bond the filter device and the extension tube, and the newly generated precipitate in the drug until reaching the capillary.
  • Such contaminated drugs may cause serious harm to the patient when injected into the human body, and the capillaries may be blocked or narrowed by impurities or sediments contained in the contaminated drugs entering the capillary tube, resulting in discontinuation of drug injection or lowering of injection volume. Problems may arise.
  • the inventors have found that at least one internal filter installed just before the liquid inlet side of the capillary inside the capillary device connected to the extension tube end, and the sharp edge of the capillary tube.
  • a sealing ring that is inserted into the capillary device after the capping, as described above, various impurities that may be included in the drug flowing into the capillary after the first filtration are removed just before the capillary inflow or blocked the occurrence of impurities.
  • the technology has been completed to prevent the drug injection interruption or the lowering of the drug injection due to capillary inflow.
  • the present invention has been made to solve the above problems, the capillary tube by impurities by effectively removing various impurities that may be included in the liquid flowing to the capillary tube even after the primary filtration by the external filter device provided in the liquid supply line It is an object of the present invention to provide a capillary device having an internal filter which prevents the blockage or narrowing of the liquid to stop the flow or slow the flow rate.
  • the present invention provides a capillary device having an internal filter having a function of preventing foreign matters from entering the liquid by scratching the inside of the capillary device by the sharp edge of the capillary when inserting the capillary into the capillary device Its purpose is.
  • an injection liquid injection device comprising a capillary device having an internal filter as described above.
  • An inlet passage having an inlet connected to a liquid supply line through which the liquid flows, and an inflow passage for flowing the liquid introduced through the inlet into an inner space of the capillary device, and in communication with the inflow passage and from the inflow passage;
  • An inlet-side housing having a hollow first engaging body portion extending toward one another;
  • An outlet passage portion having an outlet port communicating with the inner space and disposed at a position opposite to the inlet passage portion, and configured to transfer the liquid exiting from the inner space to the outside; and an outlet passage portion communicating with the outlet passage portion and from the outlet passage portion.
  • a hollow second coupling body portion extending toward the inner space, the outlet side housing having a second coupling body portion coupled to communicate with the first coupling body portion to form the inner space;
  • a capillary tube disposed on the liquid flow path in the interior space
  • At least one hydrophilic internal filter for filtering the solid impurities of the liquid introduced through the inlet and the filtered liquid into the capillary.
  • a boundary wall may be formed on an inner surface of the inflow side housing near a boundary between the inflow passage part and the first coupling body part, and the boundary wall may include the first wall.
  • a through hole may be formed that is aligned with the opening of the sealing ring located in the engaging body portion.
  • the hydrophilic internal filter is a filter installed on the boundary wall in the inflow passage, a filter provided between the boundary wall and the outer surface of the sealing ring, and the It may be at least one selected from the group consisting of a filter installed between the sealing ring inner surface and the liquid inlet side of the capillary.
  • the installation position of the hydrophilic inner filter is not limited to the above examples, and the filter may be disposed in the space between the inlet port and the capillary tube if the solid impurities of the liquid introduced through the inlet port are effectively filtered.
  • the hydrophilic internal filter can be installed and the number of installations is also adjustable.
  • the pore size of the hydrophilic internal filter may be about 30 ⁇ m to 50 ⁇ m, but the present invention is not limited thereto, and a filter having a pore having an appropriate size may be used according to the size of the solid impurities. .
  • the first coupling body of the inlet-side housing has a cylindrical first insertion portion formed stepped while extending an inner diameter from a through hole of the boundary wall, and the first It may have a cylindrical second insert formed stepped while the inner diameter is extended from the insert.
  • the second engaging body portion of the outflow side housing is guided by the second insertion portion when engaged into the first engaging body portion of the inflow side housing. At this time, the front end of the second coupling body portion does not touch the stepped portion formed between the first insertion portion and the second insertion portion and leaves a free space.
  • the outlet side housing may further include a circumferential portion facing the second coupling body portion and extending at regular intervals around the outlet passage portion. have.
  • a coupling portion of the needle or the catheter may be detachably coupled to a space between the inner surface of the circumference portion and the outer surface of the outlet passage portion.
  • the sealing ring may be composed of a substantially cylindrical body portion having an opening in the center, and a ring-shaped wing portion formed stepped while the outer diameter thereof extends from the cylindrical body portion. have.
  • the diameter of the opening of the sealing ring is formed in a tapered shape that gradually narrows toward the inside, and the outermost diameter of the opening is configured to be substantially the same as the diameter of the through hole of the boundary wall so as not to change the flow velocity of the introduced liquid.
  • the innermost diameter of the opening is configured to cover the edge of the capillary tube as much as possible so as not to block the micropath of the capillary tube, so that the pointed end of the liquid inlet side of the capillary tube can be efficiently capped.
  • the corner of the tip portion of the cylindrical body portion and the edge of the circumferential portion of the ring-shaped wing portion is rounded, so that when the capillary capped with the sealing ring is inserted into the capillary device, The end portion of the capillary device is scratched to prevent foreign matters from entering the liquid.
  • the cylindrical body portion of the sealing ring can be fitted into the first insertion portion in a fitting manner, the ring-shaped wing of the sealing ring is It may be supported by a stepped portion between the first insertion portion and the second insertion portion.
  • the ring-shaped wing portion of the sealing ring may be fitted into a space between the stepped portion and the distal end of the second coupling body portion.
  • the inlet housing and the outlet housing are each formed of a synthetic resin material, preferably ABS (Acrylonitrile Butadiene Styrene copolymer) resin, it is good to configure so as to bond by performing ultrasonic bonding to the bonding surface therebetween.
  • the sealing ring is preferably made of a silicon material so as to effectively seal the space around the capillary tube and to be fitted in close contact with the first insert.
  • the injection liquid injection device of the present invention is characterized in that it comprises a capillary device having an internal filter as described above.
  • various impurities which may be included in the liquid after the first filtration by the external filter device provided in the liquid supply line are removed immediately before the capillary inflow by the at least one internal filter installed in front of the liquid inlet side of the capillary.
  • the present invention by the sealing ring for capping the pointed end of the liquid inlet side of the capillary, the inside of the capillary device is scratched by the pointed end of the liquid inlet side of the capillary can prevent the foreign matter is generated to flow into the liquid. .
  • FIG 1 is a perspective view of a state in which the capillary device 160 having the internal filter of one embodiment of the present invention is coupled.
  • FIG 2 is an exploded perspective view of the capillary device 160 having an internal filter in one embodiment of the present invention in an exploded state.
  • FIG 3 is a longitudinal cross-sectional view of the capillary device 160 having the internal filter of one embodiment of the present invention in which the capillary device 160 provided with one hydrophilic internal filter 50 is coupled.
  • FIG. 4 is a longitudinal cross-sectional view of the capillary device 160 having the internal filter of one embodiment of the present invention in which the capillary device 160 having three hydrophilic internal filters 50, 51, and 52 are installed.
  • FIG. 5 is a longitudinal cross-sectional view of a state in which only the inlet housing 20 and the outlet housing 10 are coupled together, excluding components that are internally housed in the capillary device 160 illustrated in FIGS. 3 and 4.
  • FIG. 6 is a perspective view and a longitudinal sectional view of the sealing ring 40 embedded in the capillary device 160 with the internal filter of one embodiment of the present invention.
  • FIG. 7 is a schematic diagram illustrating an embodiment of an injection liquid injection device to which a capillary device 160 having an internal filter according to an embodiment of the present invention is applied.
  • the capillary device 160 with the internal filter of one embodiment of the invention as shown in FIGS. 1 to 4 is provided at the end of the extension tube 152 to which liquid is supplied (see FIG. 7), A needle or catheter inserted into the body is detachably coupled to the capillary device 160 having the internal filter of one embodiment of the present invention.
  • the capillary device 160 having the internal filter includes a large inlet housing 20, an outlet housing 10, a capillary tube 30, a sealing ring 40, and a hydrophilic internal filter ( 50).
  • the inlet side housing 20 has an inlet port 29 which is connected to the liquid supply line through which the liquid flows, and the liquid introduced through the inlet port 29 is capillary device ( An inflow passage 26 to flow into the inner spaces 32 and 33 of the 160, and communicates with the inflow passage 26 and extends from the inflow passage 26 toward the inner spaces 32 and 33. It is provided with a hollow first coupling body portion 27 formed. An inclined surface 262 is formed at an inlet side of the flow passage 26, and when the extension tube 152 supplied with liquid is inserted into and connected to the flow passage 26, the inclined surface 262 extends through the inclined surface 262. The end of the tube 152 is guided to facilitate insertion and removal of the extension tube.
  • a boundary wall 244 is formed on an inner surface of the inflow side housing 20 near a boundary between the inflow passage 26 and the first coupling body portion 27, and the boundary wall 244 has the first coupling body.
  • a through hole 28 is formed which is aligned with the opening 48 of the sealing ring 40 which is located in the part 27.
  • the first coupling body portion 27 has a cylindrical first insertion portion 24 formed stepwise while the inner diameter thereof is expanded from the through hole 28 of the boundary wall 244, and the inner diameter from the first insertion portion 24.
  • the expansion has a cylindrical second insertion portion 22 formed stepped.
  • the outer circumferential surface of the first coupling body portion 27 is provided with a plurality of mountain-shaped protrusions 25 extending in the longitudinal direction.
  • two mountain shaped protrusions 25 are formed on the outer circumferential surface of the first coupling body portion 27 and they are spaced apart from each other at approximately 180 °. have.
  • the outlet side housing 10 has an outlet 122 communicating with the internal spaces 32 and 33 and faces the inlet passage 26.
  • the second coupling body portion 16 couples the outlet side housing 10 to the inlet side housing 20
  • the outer surface of the second coupling body portion 16 closely fits to the inner surface of the first coupling body portion 27 to be coupled thereto. do.
  • the first coupling body portion 27 and the second coupling body portion 16, which are hollow, communicate with each other to form the internal spaces 32 and 33 (see FIG. 5).
  • the second coupling body portion 16 of the outlet side housing 10 When the second coupling body portion 16 of the outlet side housing 10 is coupled while being fitted in close contact with the first coupling body portion 27 of the inlet side housing 20, the second insertion portion 22 is coupled. Guided by and combined. In addition, the front end 162 of the second coupling body portion 16 does not touch the stepped portion 242 formed between the first insertion portion 24 and the second insertion portion 22 to leave a free space. The ring-shaped wing portion 42 of the sealing ring 40 is inserted into this clearance.
  • the outlet side housing 10 further includes a circumferential portion 14 which faces the second coupling body portion 16 and extends at regular intervals around the outlet passage portion 12.
  • a coupling portion (not shown) of the needle or the catheter may be detachably coupled to the space 142 between the inner surface of the circumference portion 14 and the outer surface of the outflow passage portion 12.
  • a plurality of protrusions 144 extending in the longitudinal direction are formed on the outer circumferential surface of the circumferential portion 14.
  • the plurality of protrusions 144 formed on the outer circumferential surface of the circumferential portion 14 and the plurality of mountain-shaped protrusions 25 formed on the outer circumferential surface of the first coupling body portion 27 described above facilitate the user's gripping. Helps to smoothly apply the user's force when rotating, dismounting and engaging the needle or catheter.
  • each of the inlet housing 20 and the outlet housing 10 is molded of a synthetic resin, preferably ABS (Acrylonitrile Butadiene Styrene copolymer) resin, and then ultrasonically bonded to the bonding surface 146 therebetween. It is good to configure to implement by combining.
  • ABS Advanced Chemical Bonding
  • the present invention is not limited thereto and that the above components may be constructed using various materials known in the art consistent with the object of the present invention.
  • the capillary tube 30 is disposed on the liquid flow path in the interior spaces 32 and 33, specifically the sealing ring 40 and the second coupling body portion. It is arranged in the space surrounded by 16. At this time, the liquid inlet side portion of the capillary tube 30 is tightly inserted into the sealing ring 40 and the liquid outlet side portion of the capillary tube 30 is inserted into the second coupling body portion 16 and accommodated therein. .
  • the accommodated capillary tube 30 can communicate with the inflow passage 26 through an opening 48 formed at one side of the sealing ring 40 while the pointed end of the liquid inlet side is capped by the sealing ring 40. Done.
  • the liquid outlet side portion of the accommodated capillary tube 30 is inserted into the second coupling body 16 so as to be in communication with the outlet passage 12 which is in communication with the second coupling body 16. do.
  • the liquid outlet side end of the capillary tube 30 is a separation prevention block 148 formed between the second coupling body portion 16 and the outlet passage portion 12 to prevent the liquid outlet side from being separated toward the outlet passage portion 12. It is supported and fixed by.
  • the sealing ring 40 has a substantially cylindrical body portion 44 having an opening 48 in the center thereof, and the outer diameter thereof extends from the cylindrical body portion 44. It is composed of a ring-shaped wing portion 42 formed stepped.
  • the diameter of the opening 48 of the sealing ring 40 is formed in a tapered shape that gradually narrows toward the inside, and the outermost diameter of the opening 48 is the through hole 28 of the boundary wall 244.
  • the inner diameter of the opening 48 does not block the micropath of the capillary tube 30 while covering the edge of the capillary tube 30 as much as possible without changing the flow velocity of the introduced liquid. It can be configured to efficiently cap the pointed end of the liquid inlet side of the capillary (30).
  • the edge of the tip portion of the cylindrical body portion 44 and the edge of the circumferential portion of the ring-shaped wing portion 42 is rounded, so that the capillary 30 capping the sealing ring 40 capillary device
  • the inside of the capillary device 16 is scratched by the pointed end of the liquid inlet side of the capillary tube 30 when inserted into the first inserting portion 24, that is, foreign matter is generated and introduced into the liquid. Can be prevented.
  • the cylindrical body portion 44 of the sealing ring 40 is fitted and coupled to the first insertion portion 24 in a fitting manner, the ring-shaped wing portion 42 of the sealing ring 40 is the first It is supported by the stepped portion 242 between the insertion portion 24 and the second insertion portion 22.
  • the ring-shaped wing portion 42 of the sealing ring 40 is fitted into the space between the stepped portion 242 and the tip 162 of the second coupling body portion 16 is coupled.
  • the liquid outlet side end of the capillary tube 30 is in communication with the outlet 122 through the outlet passage portion 12, the remaining portion of the capillary tube 30 is the sealing ring 40 and the first 2 is enclosed so as to be completely sealed by the inner wall of the engaging body portion 16 (see FIGS. 3 and 4).
  • the sealing ring 40 is preferably made of a silicon material so as to effectively seal the space around the capillary tube 30, the first inserting portion 24 and the like to be coupled and coupled.
  • the present invention is not limited thereto and that the above components may be constructed using various materials known in the art consistent with the object of the present invention.
  • a hydrophilic internal filter that filters out solid impurities of the liquid introduced through the inlet port 29 and introduces the filtered liquid into the capillary tube 30 has the inlet port 29 and the capillary tube.
  • the hydrophilic inner filter is a filter 50 (hereinafter referred to as “A filter”) installed between the boundary wall 244 and the outer surface of the sealing ring 40 and the inflow passage 26.
  • Filter 51 hereinafter referred to as "B filter”
  • filter 52 hereinafter referred to as "between" the inner surface of the sealing ring 40 and the liquid inflow side of the capillary tube 30
  • FIG. 3 shows an example in which one hydrophilic inner filter 50 is installed between the boundary wall 244 and the outer ring 40, and in FIG. 4, three hydrophilic inner filters as described above.
  • An example in which all of 50, 51, and 52 are provided is shown.
  • a B filter or a C filter may be installed alone, and may be installed as a combination of A filter and B filter, a combination of A filter and C filter, and a combination of B filter and C filter. .
  • the installation positions of the hydrophilic internal filters 50, 51, and 52 are not limited to the above examples, provided that the solid impurities of the liquid introduced through the inlet port 29 are effectively filtered.
  • the hydrophilic internal filter 50, 51, 52 can be installed in the space between the inlet 29 and the capillary 30, and the installation quantity can be adjusted.
  • the hydrophilic inner filter 50, 51, 52 removes various impurities that may be included in the flowing liquid even after primary filtration by the external filter device 150, immediately before the capillary 30 inflow.
  • the problem of interrupting liquid injection or lowering the liquid injection amount due to capillary inflow can be prevented in advance (see FIG. 7).
  • the capillary device 160 of the present invention can be applied to the injection liquid injection device 100 shown in WO 2010/120051 A2 as shown in FIG. 7.
  • gas generated from the gas supply unit 130 disposed behind the piston 140 pushes the piston 140 forward and the drug in the cylinder 110.
  • the drug stored in the storage space 120 is pushed out to the flow tube 151 at a constant flow rate by the piston 140.
  • Impurities such as solid particles and gas, such as air, contained in the drug flowing from the drug storage space 120 to the flow tube 151 are primarily by a hydrophilic filter and a hydrophobic filter provided to the external filter device 150. Removed.
  • new contaminants may exist between the external filter device 150 and the capillary device 160 even after the first filtration by the external filter device 150.
  • particles and other contaminants present in the extension tube 152, an adhesive component used to connect the external filter device 150 and the extension tube 152, the extension tube 152 and the capillary device There may be an adhesive component used to connect 160 and a precipitate depending on the nature of the drug.
  • the A filter, B filter and / or C filter provided in the capillary device 160 of the present invention as described above filters such impurities before entering the capillary 30 so that these impurities block or narrow the capillary 30. Undesirable phenomenon can be prevented in advance.
  • the hydrophilic inner filter (50, 51, 52) can be used as long as it is well known in the art and usually available as a filter to filter out the solid impurities and pass through the liquid.
  • the pore size of the hydrophilic inner filter 50, 51, 52 may be about 30 ⁇ m to 50 ⁇ m, but the present invention is not limited thereto, and a filter having a pore having an appropriate size may be used according to the size of solid impurities. Of course it can.

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  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
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Abstract

The present invention provides a capillary device comprising an internal filter. According to the present invention, various impurities, which can be contained in a liquid after a first filtering by an external filter device provided at a liquid supply line, are removed just before flowing into a capillary by at least one internal filter provided in front of the liquid inflow side of the capillary, and thus an interruption during liquid injection or a decline in the liquid injection amount can be prevented in advance by the inflow of impurities into the capillary. In addition, the present invention can prevent the inflow, into the liquid, of foreign matter generated when the inside of the device is scratched by the sharp end of the liquid inflow side of a capillary, by using a sealing ring for capping the sharp end of the liquid inflow side of a capillary.

Description

내부 필터를 구비한 모세관 장치 및 이를 구비한 주사액 주입장치Capillary device with internal filter and injection solution injection device with the same
본 발명은 내부 필터를 구비한 모세관 장치에 관한 것으로서, 더욱 상세하게는 액체공급라인에 제공된 외부 필터장치에 의한 1차적인 여과 후에도 모세관까지 유동하는 액체 내에 포함될 수 있는 각종 불순물을 효과적으로 제거하여 불순물에 의하여 모세관이 막히거나 좁아져서 액체의 유동이 멈추거나 유속이 느려지는 것을 방지하는 내부 필터를 구비한 모세관 장치에 관한 것이다.The present invention relates to a capillary device having an internal filter, and more particularly, to effectively remove various impurities that may be contained in the liquid flowing to the capillary even after primary filtration by an external filter device provided in the liquid supply line. The present invention relates to a capillary device having an internal filter which prevents the capillary from clogging or narrowing so that the flow of liquid stops or the flow rate is slowed down.
또한, 본 발명은 모세관을 모세관 장치 내부에 삽입할 때 모세관의 뾰족한 모서리에 의해 모세관 장치 내부가 긁혀서 이물질이 발생하여 액체 내에 유입되는 것을 방지하는 기능을 지닌 내부 필터를 구비한 모세관 장치에 관한 것이다.In addition, the present invention relates to a capillary device having an internal filter having a function of preventing foreign matter from entering the liquid by scratching the inside of the capillary device by the sharp edge of the capillary when the capillary is inserted into the capillary device. .
추가로, 본 발명은 이러한 내부 필터를 구비한 모세관 장치를 포함하는 주사액 주입장치에 관한 것이다.Further, the present invention relates to an injection liquid injection device comprising a capillary device with such an internal filter.
일반적으로, 환자에게는 주사액을 지속적으로 주입하여야 하는 경우가 많다. 이때 주사액 주입장치가 이용되는데, 주사액 주입장치는 주사액에 포함된 이물질과 공기 등을 제거하기 위해 필터장치를 포함한다.In general, patients often need to be constantly injected with injections. At this time, the injection liquid injection device is used, the injection liquid injection device includes a filter device for removing foreign matter and air contained in the injection liquid.
일반적으로 종래의 주사액 주입장치는 주사액이 저장되어 있는 병이나 팩(pack)과 같은 주사액 저장수단과, 이 주사액 저장수단으로부터 연장되도록 구비되어 주사액 저장수단으로부터 공급되는 주사액이 이송되는 가요성의 연장튜브를 구비한다. 연장튜브에는 공급되는 주사액 내의 이물질과 공기를 걸러서 제거하기 위한 외부 필터장치가 구비되며, 연장튜브의 종단부에는 환자의 신체 내로 삽입되는 주사바늘 또는 카테터(catheter)가 탈착 가능하게 결합되게 되는 말단접속구가 구비되어 있다(미국특허번호 제4,781,698호 참조). In general, a conventional injection liquid injecting apparatus includes an injection liquid storage means such as a bottle or a pack in which an injection liquid is stored, and a flexible extension tube which is provided to extend from the injection liquid storage means and in which the injection liquid supplied from the injection liquid storage means is transferred. Equipped. The extension tube is provided with an external filter device for filtering and removing foreign substances and air in the supplied injection liquid, and the terminal end of the extension tube is detachably coupled to the needle or catheter inserted into the patient's body. (See US Pat. No. 4,781,698).
사용자가 주사바늘이나 카테터를 환자의 인체 내에 삽입하게 되면, 주사액 저장수단 내부에 저장되어 있던 주사액이 소량씩 배출 공급되어 연장튜브를 따라 흐른 다음, 종국에는 말단접속구에 결합되어 있는 주사바늘이나 카테터를 통해 환자의 인체 내로 주입되게 된다.When the user inserts the needle or catheter into the patient's body, the injection liquid stored in the injection liquid storage means is discharged and supplied in small portions to flow along the extension tube, and finally, the needle or catheter coupled to the terminal connector Through the patient's body.
주사액이 환자의 인체 내로 주입될 때 주사액과 함께 이물질(예컨대, 유리 앰플을 딸 때 발생되는 유리 파편)이나 공기가 함께 주입되게 되면, 환자의 혈관이나 뇌에 손상을 가해 치명적인 위험을 초래할 수 있다. 따라서, 이를 방지하기 위해 연장튜브의 경로상에는 소수성 필터와 친구성 필터를 구비한 외부 필터장치가 구비되게 되며, 상기 외부 필터장치와 연결되는 연장튜브의 말단부 내부에는 최종적으로 약물의 유량을 조절하는 역할을 하는 모세관이 구비된다. 연장튜브의 말단부 내부에 설치된 모세관은 항암제나 항생제와 같이 약물의 주입 속도가 빠를 경우 환자의 장기에 치명적 손상을 유발하는 약물의 과도한 주입을 방지한다. When an injection is injected into a patient's body, when foreign matter (eg, glass fragments generated when opening a glass ampoule) or air is injected together with the injection, damage to a patient's blood vessels or brain may cause a fatal risk. Accordingly, in order to prevent this, an external filter device having a hydrophobic filter and a friend filter is provided on the path of the extension tube, and finally, the end of the extension tube connected to the external filter device controls the flow rate of the drug. Capillary tube is provided. Capillaries placed inside the distal ends of extension tubes prevent excessive injection of drugs that can cause fatal damage to the patient's organs at high rates of drug injection, such as anticancer drugs or antibiotics.
그러나, 종래의 필터장치는 약물 내에 포함된 공기와 고체 불순물을 완전히 제거하기 위해 여러 개의 필터 소재를 채택하는 것이 필요하고 이로 인해 구조적으로 복잡해 질 수 밖에 없어 그 조립이 복잡하고 제조단가가 상승하는 문제점이 있었다. 또한, 공기와 고체 불순물의 완전한 제거를 위해 여러 개의 필터 소재를 채택하고 있는 종래의 필터장치는 일정한 속도로 환자에게 주입되어야 하는 약물의 유속을 느려지게 하는 문제점이 있었을 뿐만 아니라, 공기와 고체 불순물의 제거라는 효과 면에서도 만족스럽지 못한 문제점이 있었다.However, the conventional filter device is required to adopt a plurality of filter materials to completely remove the air and solid impurities contained in the drug, which is due to the structural complexity, the assembly is complicated and the manufacturing cost increases There was this. In addition, the conventional filter device employing a plurality of filter materials for the complete removal of air and solid impurities not only has a problem of slowing the flow rate of the drug to be injected into the patient at a constant rate, There was an unsatisfactory problem in terms of the effect of removal.
이러한 종래의 필터장치의 개선과 관련하여 본 발명자는 새로운 구성의 필터장치들과 이들을 구비한 주사액 주입장치들을 제시한 바 있다. 이 새로운 장치들은 약물 내의 공기와 유리조각과 같은 고체 불순물을 효과적으로 제거하도록 구성되어 있다. 이러한 새로운 장치의 예가 국제공개특허공보 WO 2007/117119 A1호 및 대한민국 공개특허공보 제10-2008-0104487호에 개시되어 있다. 그러나, 상기 필터장치들 및 이들을 구비한 주사액 주입장치가 우수한 기술임에도 다른 우수한 기술과 마찬가지로 끊임없는 개선이 이루어질 수 있는 것이다. In connection with the improvement of the conventional filter device, the present inventor has proposed a novel configuration of the filter device and the injection liquid injection device having the same. These new devices are designed to effectively remove solid impurities such as air and glass chips in the drug. Examples of such new devices are disclosed in WO 2007/117119 A1 and Korean Patent Publication No. 10-2008-0104487. However, even though the filter devices and the injection liquid injection device including the same are excellent technologies, the continuous improvement can be made like other excellent technologies.
종래의 주사액 주입장치에서는 기존의 외부 필터장치를 사용하여 약물과 같은 액체 내에 포함된 파티클과 같은 불순물과, 유동하는 약물 내에서 새로이 생성되는 침전물 등의 고체 입자를 1차적으로 여과할 수 있다. 그러나, 종래 기술에서는 상기와 같이 1차적으로 여과된 약물이 상기 외부 필터장치와 연결된 연장튜브를 통과하여 유량 조절의 역할을 하는 모세관까지 도달할 때, 상기 연장튜브 내부에 존재할 수 있는 불순물, 상기 외부 필터장치와 상기 연장튜브를 접착하는데 사용하는 접착제 성분, 그리고 상기 모세관까지 도달할 때까지 약물 내에서 다시 새로이 생성되는 침전물 등에 의하여 약물이 다시 오염될 수 있다. 이와 같은 오염된 약물은 인체에 주입될 경우 환자에게 치명적인 위해를 가할 수 있을 뿐만 아니라 모세관에 유입되는 오염된 약물에 포함된 불순물이나 침전물 등에 의해 모세관이 막히거나 좁아져서 약물 주입 중단이나 주입량 저하 등의 문제가 발생할 수도 있다. In the conventional injection liquid injector, a conventional external filter device may primarily filter impurities such as particles contained in a liquid such as a drug and solid particles such as precipitates newly generated in a flowing drug. However, in the prior art, when the first filtered drug passes through the extension tube connected to the external filter device to the capillary tube, which controls the flow rate, impurities that may exist inside the extension tube, the external The drug may be contaminated again by the adhesive component used to bond the filter device and the extension tube, and the newly generated precipitate in the drug until reaching the capillary. Such contaminated drugs may cause serious harm to the patient when injected into the human body, and the capillaries may be blocked or narrowed by impurities or sediments contained in the contaminated drugs entering the capillary tube, resulting in discontinuation of drug injection or lowering of injection volume. Problems may arise.
따라서, 본 발명이 속하는 기술분야에서는 액체공급라인에 제공된 외부 필터장치에 의한 1차 여과 후에도 모세관까지 유동하는 약물 내에 포함될 수 있는 각종 불순물을 효과적으로 제거하여 불순물에 의하여 모세관이 막히거나 좁아져서 약물의 유동이 멈추거나 유속이 느려지는 것을 방지하는 필터장치 내지는 모세관 장치의 개발에 대한 요구가 꾸준히 지속되고 있다.Therefore, in the technical field to which the present invention belongs, various impurities that may be included in the drug flowing to the capillary even after the first filtration by an external filter device provided in the liquid supply line are effectively removed, so that the capillary is blocked or narrowed by the impurities, and thus the drug flows. There is a continuing need for the development of filter devices or capillary devices to prevent this stop or the flow rate from slowing down.
본 발명자는 전술한 바와 같은 문제점을 해결하기 위해 예의 연구를 거듭한 결과, 연장튜브 말단부에 연결되는 모세관 장치의 내부에서 모세관의 액체 유입측 바로 앞에 설치되는 적어도 하나의 내부 필터와, 모세관의 뾰족한 모서리를 씌운 후 모세관 장치 내부에 삽입되는 밀봉링을 구성함으로써, 전술한 바와 같이 1차 여과 후 모세관까지 유동하는 약물 내에 포함될 수 있는 각종 불순물을 모세관 유입 직전에 제거하거나 이물질의 발생 소지를 차단하여 불순물의 모세관 유입에 의한 약물 주입 중단 또는 약물 주입량의 저하 문제를 방지할 수 있는 기술을 완성하기에 이르렀다.As a result of intensive studies to solve the problems described above, the inventors have found that at least one internal filter installed just before the liquid inlet side of the capillary inside the capillary device connected to the extension tube end, and the sharp edge of the capillary tube. By forming a sealing ring that is inserted into the capillary device after the capping, as described above, various impurities that may be included in the drug flowing into the capillary after the first filtration are removed just before the capillary inflow or blocked the occurrence of impurities. The technology has been completed to prevent the drug injection interruption or the lowering of the drug injection due to capillary inflow.
본 발명은 상기와 같은 제반 문제점을 해결하기 위하여 안출된 것으로서, 액체공급라인에 제공된 외부 필터장치에 의한 1차적인 여과 후에도 모세관까지 유동하는 액체 내에 포함될 수 있는 각종 불순물을 효과적으로 제거하여 불순물에 의하여 모세관이 막히거나 좁아져서 액체의 유동이 멈추거나 유속이 느려지는 것을 방지하는 내부 필터를 구비한 모세관 장치를 제공하는데 그 목적이 있다.The present invention has been made to solve the above problems, the capillary tube by impurities by effectively removing various impurities that may be included in the liquid flowing to the capillary tube even after the primary filtration by the external filter device provided in the liquid supply line It is an object of the present invention to provide a capillary device having an internal filter which prevents the blockage or narrowing of the liquid to stop the flow or slow the flow rate.
또한, 본 발명은 모세관을 모세관 장치 내부에 삽입할 때 모세관의 뾰족한 모서리에 의해 모세관 장치 내부가 긁혀서 이물질이 발생하여 액체 내에 유입되는 것을 방지하는 기능을 지닌 내부 필터를 구비한 모세관 장치를 제공하는데 그 목적이 있다.In addition, the present invention provides a capillary device having an internal filter having a function of preventing foreign matters from entering the liquid by scratching the inside of the capillary device by the sharp edge of the capillary when inserting the capillary into the capillary device Its purpose is.
추가로, 본 발명은 전술한 바와 같은 내부 필터를 구비한 모세관 장치를 포함하는 주사액 주입장치를 제공하는데 그 목적이 있다.In addition, it is an object of the present invention to provide an injection liquid injection device comprising a capillary device having an internal filter as described above.
본 발명의 일실시예의 내부 필터를 구비한 모세관 장치는,Capillary device having an internal filter of one embodiment of the present invention,
액체가 유동하는 액체 공급라인과 연결되는 유입구를 갖고 있고 상기 유입구를 통해 유입된 액체를 모세관 장치의 내부 공간으로 유동시키는 유입통로부와, 상기 유입통로부와 연통되고 상기 유입통로부로부터 상기 내부 공간 쪽으로 연장되어 형성된 중공형의 제1 결합 몸체부를 구비하는 유입측 하우징과,An inlet passage having an inlet connected to a liquid supply line through which the liquid flows, and an inflow passage for flowing the liquid introduced through the inlet into an inner space of the capillary device, and in communication with the inflow passage and from the inflow passage; An inlet-side housing having a hollow first engaging body portion extending toward one another;
상기 내부 공간과 연통되는 유출구를 갖고 있고 상기 유입통로부와 대향되는 위치에 배치되며 상기 내부 공간으로부터 빠져나온 액체를 외부로 이송하는 유출통로부와, 상기 유출통로부와 연통되고 상기 유출통로부로부터 상기 내부 공간 쪽으로 연장되어 형성된 중공형의 제2 결합 몸체부로서, 상기 제1 결합 몸체부와 연통되면서 결합되어 상기 내부 공간을 형성하는 제2 결합 몸체부를 구비하는 유출측 하우징과,An outlet passage portion having an outlet port communicating with the inner space and disposed at a position opposite to the inlet passage portion, and configured to transfer the liquid exiting from the inner space to the outside; and an outlet passage portion communicating with the outlet passage portion and from the outlet passage portion. A hollow second coupling body portion extending toward the inner space, the outlet side housing having a second coupling body portion coupled to communicate with the first coupling body portion to form the inner space;
상기 내부 공간 내의 액체 유동 경로 상에 배치되는 모세관과,A capillary tube disposed on the liquid flow path in the interior space;
상기 모세관의 액체 유입 측의 뾰족한 단부를 캡핑하고, 상기 내부 공간에서 상기 모세관 주위의 공간을 밀봉하되 상기 유입통로부로부터의 액체가 상기 모세관을 통해 상기 유출통로부로 유동가능하도록 일측에 개구가 형성된 밀봉링과,Capping the sharp end of the capillary liquid inlet side and sealing the space around the capillary tube in the inner space but having an opening formed at one side such that liquid from the inflow passage portion can flow through the capillary tube to the outlet passage portion Rings,
상기 유입구와 상기 모세관 사이의 공간에 위치하고, 상기 유입구를 통해 유입된 액체의 고체 불순물을 걸러내고 여과된 액체는 상기 모세관으로 유입시키는 적어도 하나의 친수성 내부 필터를 포함한다.Located in the space between the inlet and the capillary, at least one hydrophilic internal filter for filtering the solid impurities of the liquid introduced through the inlet and the filtered liquid into the capillary.
본 발명의 일실시예의 내부 필터를 구비한 모세관 장치에 있어서, 상기 유입측 하우징의 내면에는 상기 유입통로부와 상기 제1 결합 몸체부의 경계 부근에서 경계벽이 형성될 수 있고, 상기 경계벽에는 상기 제1 결합 몸체부 내에 위치하는 상기 밀봉링의 개구와 정렬되는 관통구가 형성될 수 있다.In the capillary device having an internal filter according to an embodiment of the present invention, a boundary wall may be formed on an inner surface of the inflow side housing near a boundary between the inflow passage part and the first coupling body part, and the boundary wall may include the first wall. A through hole may be formed that is aligned with the opening of the sealing ring located in the engaging body portion.
본 발명의 일실시예의 내부 필터를 구비한 모세관 장치에 있어서, 상기 친수성 내부 필터는 상기 유입통로부 내에서 상기 경계벽 상에 설치되는 필터, 상기 경계벽과 상기 밀봉링 외면 사이에 설치되는 필터, 및 상기 밀봉링 내면과 상기 모세관의 액체 유입측 사이에 설치되는 필터로 구성된 군으로부터 선택되는 적어도 하나일 수 있다. 이러한 친수성 내부 필터에 의해, 외부 필터장치에 의한 1차 여과 후에도 유동하는 액체 내에 포함될 수 있는 각종 불순물이 모세관 유입 직전에 제거되어 불순물의 모세관 유입에 의한 약물 주입 중단 또는 약물 주입량의 저하 문제를 사전에 방지할 수 있다.In the capillary device having an internal filter of an embodiment of the present invention, the hydrophilic internal filter is a filter installed on the boundary wall in the inflow passage, a filter provided between the boundary wall and the outer surface of the sealing ring, and the It may be at least one selected from the group consisting of a filter installed between the sealing ring inner surface and the liquid inlet side of the capillary. With this hydrophilic internal filter, various impurities that may be contained in the flowing liquid even after the first filtration by the external filter device are removed immediately before the capillary inflow, and thus the problem of stopping the drug injection or lowering the amount of drug injection due to the capillary inflow of impurities in advance. It can prevent.
그러나, 본 발명에 있어서 상기 친수성 내부 필터의 설치 위치는 상기와 같은 예시에만 한정되는 것이 아니며, 상기 유입구를 통해 유입된 액체의 고체 불순물을 효과적으로 여과하는 곳이라면 상기 유입구와 상기 모세관 사이의 공간 내에서 상기 친수성 내부 필터를 설치할 수 있으며 설치 수량도 조절가능하다. 또한, 일례로서 상기 친수성 내부 필터의 공극 크기는 약 30㎛ 내지 50㎛일 수 있으나, 본 발명은 이에 제한되는 것이 아니고 고체 불순물의 크기에 따라 적절한 크기의 공극을 가진 필터를 사용할 수 있음은 물론이다.However, in the present invention, the installation position of the hydrophilic inner filter is not limited to the above examples, and the filter may be disposed in the space between the inlet port and the capillary tube if the solid impurities of the liquid introduced through the inlet port are effectively filtered. The hydrophilic internal filter can be installed and the number of installations is also adjustable. In addition, as an example, the pore size of the hydrophilic internal filter may be about 30 μm to 50 μm, but the present invention is not limited thereto, and a filter having a pore having an appropriate size may be used according to the size of the solid impurities. .
본 발명의 일실시예의 내부 필터를 구비한 모세관 장치에 있어서, 상기 유입측 하우징의 제1 결합 몸체부는 상기 경계벽의 관통구로부터 내경이 확장되면서 단차지게 형성된 원통형의 제1 삽입부와, 상기 제1 삽입부로부터 내경이 확장되면서 단차지게 형성된 원통형의 제2 삽입부를 구비할 수 있다. 상기 유출측 하우징의 제2 결합 몸체부는 상기 유입측 하우징의 제1 결합 몸체부 내로 결합될 때, 상기 제2 삽입부에 의해 안내된다. 이때 상기 제2 결합 몸체부의 선단은 상기 제1 삽입부와 상기 제2 삽입부 사이에 형성된 단턱부에 맞닿지 않고 여유 공간을 남기게 된다.In the capillary device having an internal filter according to an embodiment of the present invention, the first coupling body of the inlet-side housing has a cylindrical first insertion portion formed stepped while extending an inner diameter from a through hole of the boundary wall, and the first It may have a cylindrical second insert formed stepped while the inner diameter is extended from the insert. The second engaging body portion of the outflow side housing is guided by the second insertion portion when engaged into the first engaging body portion of the inflow side housing. At this time, the front end of the second coupling body portion does not touch the stepped portion formed between the first insertion portion and the second insertion portion and leaves a free space.
본 발명의 일실시예의 내부 필터를 구비한 모세관 장치에 있어서, 상기 유출측 하우징은 상기 제2 결합 몸체부에 대해 대향하고 상기 유출통로부의 주위로 일정한 간격을 두고 연장되어 형성된 둘레부를 더 포함할 수 있다. 상기 둘레부 내면과 상기 유출통로부의 외면 사이의 공간에는 주사바늘이나 카테터의 결합부가 탈착 가능하게 결합할 수 있다.In the capillary device having an internal filter according to an embodiment of the present invention, the outlet side housing may further include a circumferential portion facing the second coupling body portion and extending at regular intervals around the outlet passage portion. have. A coupling portion of the needle or the catheter may be detachably coupled to a space between the inner surface of the circumference portion and the outer surface of the outlet passage portion.
본 발명의 일실시예의 내부 필터를 구비한 모세관 장치에 있어서, 상기 밀봉링은 중앙에 개구가 형성된 대략 원통형 몸체부와, 이러한 원통형 몸체부로부터 외경이 확장되면서 단차지게 형성된 링형상 날개부로 구성될 수 있다. 상기 밀봉링의 개구의 직경은 안쪽으로 향할수록 점차 좁아지는 테이퍼 형상으로 형성되어 있는데, 상기 개구의 가장 바깥쪽 직경은 상기 경계벽의 관통구의 직경과 거의 동일하도록 구성되어 유입된 액체의 유속을 변화시키지 않고 상기 개구의 가장 안쪽 직경은 상기 모세관의 모서리 부분을 최대한 덮으면서도 상기 모세관의 미세통로를 막지 않도록 구성되어 있어 상기 모세관의 액체 유입 측의 뾰족한 단부를 효율적으로 캡핑할 수 있다. 또한, 상기 원통형 몸체부의 선단 부분의 모서리와 링형상 날개부의 둘레 부분의 모서리는 라운딩처리가 되어 있어, 상기 밀봉링을 캡핑한 모세관을 모세관 장치의 내부에 삽입할 때 상기 모세관의 액체 유입 측의 뾰족한 단부에 의해 모세관 장치의 내부가 긁혀서 이물질이 발생하여 액체 내에 유입되는 것을 방지할 수 있게 된다.In the capillary device having an internal filter of an embodiment of the present invention, the sealing ring may be composed of a substantially cylindrical body portion having an opening in the center, and a ring-shaped wing portion formed stepped while the outer diameter thereof extends from the cylindrical body portion. have. The diameter of the opening of the sealing ring is formed in a tapered shape that gradually narrows toward the inside, and the outermost diameter of the opening is configured to be substantially the same as the diameter of the through hole of the boundary wall so as not to change the flow velocity of the introduced liquid. In addition, the innermost diameter of the opening is configured to cover the edge of the capillary tube as much as possible so as not to block the micropath of the capillary tube, so that the pointed end of the liquid inlet side of the capillary tube can be efficiently capped. In addition, the corner of the tip portion of the cylindrical body portion and the edge of the circumferential portion of the ring-shaped wing portion is rounded, so that when the capillary capped with the sealing ring is inserted into the capillary device, The end portion of the capillary device is scratched to prevent foreign matters from entering the liquid.
본 발명의 바람직한 일실시예의 내부 필터를 구비한 모세관 장치에 있어서, 상기 밀봉링의 원통형 몸체부는 상기 제1 삽입부에 억지끼워맞춤 방식으로 끼워져 결합될 수 있고, 상기 밀봉링의 링형상 날개부는 상기 제1 삽입부와 상기 제2 삽입부 사이의 단턱부에 의해 지지될 수 있다. 그리고, 상기 밀봉링의 링형상 날개부는 상기 단턱부와 상기 제2 결합 몸체부의 선단 사이의 공간에 끼워져 결합될 수 있다.In the capillary device having an internal filter of a preferred embodiment of the present invention, the cylindrical body portion of the sealing ring can be fitted into the first insertion portion in a fitting manner, the ring-shaped wing of the sealing ring is It may be supported by a stepped portion between the first insertion portion and the second insertion portion. The ring-shaped wing portion of the sealing ring may be fitted into a space between the stepped portion and the distal end of the second coupling body portion.
한편, 상기 유입측 하우징과 상기 유출측 하우징 각각은 합성수지 재질, 바람직하게는 ABS(Acrylonitrile Butadiene Styrene copolymer) 수지로 성형한 후, 이들 사이의 접합면에 대해 초음파 접합을 실시하여 결합하도록 구성하는 것이 좋다. 또한, 상기 밀봉링은 모세관 주위의 공간을 효과적으로 밀봉하고 상기 제1 삽입부 등에 밀착되어 끼워져 결합될 수 있도록 실리콘 재질로 구성하는 것이 바람직하다. 그러나, 본 발명은 이에 제한되는 것이 아니고 본 발명의 목적에 부합되는 당업계에 알려진 다양한 재료를 사용하여 상기 구성요소들을 구성할 수 있음을 본 발명이 속하는 기술분야의 당업자라면 용이하게 이해할 것이다.On the other hand, the inlet housing and the outlet housing are each formed of a synthetic resin material, preferably ABS (Acrylonitrile Butadiene Styrene copolymer) resin, it is good to configure so as to bond by performing ultrasonic bonding to the bonding surface therebetween. . In addition, the sealing ring is preferably made of a silicon material so as to effectively seal the space around the capillary tube and to be fitted in close contact with the first insert. However, it will be readily understood by those skilled in the art that the present invention is not limited thereto and that the above components may be constructed using various materials known in the art consistent with the object of the present invention.
또한, 본 발명의 주사액 주입장치는 전술한 바와 같은 내부 필터를 구비한 모세관 장치를 포함하는 것을 특징으로 한다.In addition, the injection liquid injection device of the present invention is characterized in that it comprises a capillary device having an internal filter as described above.
본 발명에 따르면, 액체공급라인에 제공된 외부 필터장치에 의한 1차적인 여과 후에도 모세관까지 유동하는 액체 내에 포함될 수 있는 각종 불순물을 효과적으로 제거할 수 있고, 궁극적으로는 불순물에 의하여 모세관이 막히거나 좁아져서 액체의 유동이 멈추거나 유속이 느려지는 문제를 사전에 방지할 수 있는 장점이 있다. According to the present invention, even after primary filtration by an external filter device provided in the liquid supply line, various impurities that may be contained in the liquid flowing to the capillary can be effectively removed, and ultimately the capillary is blocked or narrowed by the impurities. There is an advantage in that the flow of the liquid stops or the flow rate can be prevented in advance.
즉, 본 발명에 따르면, 액체공급라인에 제공된 외부 필터장치에 의한 1차 여과 후 액체 내에 포함될 수 있는 각종 불순물이 모세관의 액체 유입 측의 앞에 설치되는 적어도 하나의 내부 필터에 의해 모세관 유입 직전에 제거됨으로써 불순물의 모세관 유입에 의한 액체 주입 중단 또는 액체 주입량의 저하 문제를 사전에 방지할 수 있는 장점이 있다. That is, according to the present invention, various impurities which may be included in the liquid after the first filtration by the external filter device provided in the liquid supply line are removed immediately before the capillary inflow by the at least one internal filter installed in front of the liquid inlet side of the capillary. By doing so, there is an advantage of preventing the problem of stopping the liquid injection or lowering of the liquid injection amount due to the inflow of the capillary of impurities.
또한, 본 발명은 모세관의 액체 유입 측의 뾰족한 단부를 캡핑하는 밀봉링에 의해, 모세관의 액체 유입 측의 뾰족한 단부에 의해 모세관 장치 내부가 긁혀서 이물질이 발생하여 액체 내에 유입되는 것을 방지할 수 있다.In addition, the present invention by the sealing ring for capping the pointed end of the liquid inlet side of the capillary, the inside of the capillary device is scratched by the pointed end of the liquid inlet side of the capillary can prevent the foreign matter is generated to flow into the liquid. .
도 1은 본 발명의 일실시예의 내부 필터를 구비한 모세관 장치(160)가 결합된 상태의 사시도이다.1 is a perspective view of a state in which the capillary device 160 having the internal filter of one embodiment of the present invention is coupled.
도 2는 본 발명의 일실시예의 내부 필터를 구비한 모세관 장치(160)가 분해된 상태의 분해 사시도이다.2 is an exploded perspective view of the capillary device 160 having an internal filter in one embodiment of the present invention in an exploded state.
도 3은 본 발명의 일실시예의 내부 필터를 구비한 모세관 장치(160)로서 1개의 친수성 내부 필터(50)가 설치된 모세관 장치(160)가 결합된 상태의 종단면도이다.3 is a longitudinal cross-sectional view of the capillary device 160 having the internal filter of one embodiment of the present invention in which the capillary device 160 provided with one hydrophilic internal filter 50 is coupled.
도 4는 본 발명의 일실시예의 내부 필터를 구비한 모세관 장치(160)로서 3개의 친수성 내부 필터(50, 51, 52)가 설치된 모세관 장치(160)가 결합된 상태의 종단면도이다.4 is a longitudinal cross-sectional view of the capillary device 160 having the internal filter of one embodiment of the present invention in which the capillary device 160 having three hydrophilic internal filters 50, 51, and 52 are installed.
도 5는 도 3 및 도 4에 도시된 모세관 장치(160)에서 내부 수납된 구성요소들을 배제하고 유입측 하우징(20)과 유출측 하우징(10)만이 결합된 상태의 종단면도이다.5 is a longitudinal cross-sectional view of a state in which only the inlet housing 20 and the outlet housing 10 are coupled together, excluding components that are internally housed in the capillary device 160 illustrated in FIGS. 3 and 4.
도 6은 본 발명의 일실시예의 내부 필터를 구비한 모세관 장치(160)에 내장되는 밀봉링(40)의 사시도 및 종단면도이다.6 is a perspective view and a longitudinal sectional view of the sealing ring 40 embedded in the capillary device 160 with the internal filter of one embodiment of the present invention.
도 7은 본 발명의 일실시예에 따른 내부 필터를 구비한 모세관 장치(160)가 적용된 주사액 주입장치의 일실시예를 도시하는 개략적인 구성도이다.7 is a schematic diagram illustrating an embodiment of an injection liquid injection device to which a capillary device 160 having an internal filter according to an embodiment of the present invention is applied.
이하, 첨부된 도면을 참조하여 본 발명의 바람직한 실시예를 설명하면 다음과 같다. 본 발명의 하기 실시예는 본 발명을 구체화하기 위한 것일 뿐 본 발명의 권리범위를 제한하거나 한정하는 것이 아님은 물론이다. 본 발명의 상세한 설명 및 실시예로부터 본 발명이 속하는 기술분야의 전문가가 용이하게 유추할 수 있는 것은 본 발명의 권리범위에 속하는 것으로 해석된다. 본 발명에 인용된 참고문헌들은 본 발명에 참고로서 통합된다.Hereinafter, exemplary embodiments of the present invention will be described with reference to the accompanying drawings. The following examples of the present invention are not intended to limit or limit the scope of the present invention only to embody the present invention. From the detailed description and examples of the present invention, those skilled in the art to which the present invention pertains can easily be interpreted as belonging to the scope of the present invention. References cited in the present invention are incorporated herein by reference.
도 1 내지 도 4에 도시된 바와 같은 본 발명의 일실시예의 내부 필터를 구비한 모세관 장치(160)는 액체가 공급되는 연장튜브(152)의 종단부에 구비되고(도 7 참조), 환자의 신체 내로 삽입되는 주사바늘 또는 카테터(catheter) 등이 본 발명의 일실시예의 내부 필터를 구비한 모세관 장치(160)에 탈착 가능하게 결합되어 사용된다. The capillary device 160 with the internal filter of one embodiment of the invention as shown in FIGS. 1 to 4 is provided at the end of the extension tube 152 to which liquid is supplied (see FIG. 7), A needle or catheter inserted into the body is detachably coupled to the capillary device 160 having the internal filter of one embodiment of the present invention.
우선, 본 발명의 일실시예의 내부 필터를 구비한 모세관 장치(160)는, 크게 유입측 하우징(20), 유출측 하우징(10), 모세관(30), 밀봉링(40) 및 친수성 내부 필터(50)로 구성된다.First, the capillary device 160 having the internal filter according to the embodiment of the present invention includes a large inlet housing 20, an outlet housing 10, a capillary tube 30, a sealing ring 40, and a hydrophilic internal filter ( 50).
도 2 내지 도 5에 도시된 바와 같이, 상기 유입측 하우징(20)은 액체가 유동하는 액체 공급라인과 연결되는 유입구(29)를 갖고 있고 상기 유입구(29)를 통해 유입된 액체를 모세관 장치(160)의 내부 공간(32, 33)으로 유동시키는 유입통로부(26)와, 상기 유입통로부(26)와 연통되고 상기 유입통로부(26)로부터 상기 내부 공간(32, 33) 쪽으로 연장되어 형성된 중공형의 제1 결합 몸체부(27)를 구비한다. 상기 유동통로부(26)의 유입구 측에는 경사면(262)이 형성되어 있는데, 액체가 공급되는 연장튜브(152)를 상기 유동통로부(26) 내로 삽입하여 연결할 때 상기 경사면(262)을 통해 상기 연장튜브(152)의 종단부가 안내됨으로써 상기 연장튜브를 용이하게 삽입 및 제거할 수 있다. 2 to 5, the inlet side housing 20 has an inlet port 29 which is connected to the liquid supply line through which the liquid flows, and the liquid introduced through the inlet port 29 is capillary device ( An inflow passage 26 to flow into the inner spaces 32 and 33 of the 160, and communicates with the inflow passage 26 and extends from the inflow passage 26 toward the inner spaces 32 and 33. It is provided with a hollow first coupling body portion 27 formed. An inclined surface 262 is formed at an inlet side of the flow passage 26, and when the extension tube 152 supplied with liquid is inserted into and connected to the flow passage 26, the inclined surface 262 extends through the inclined surface 262. The end of the tube 152 is guided to facilitate insertion and removal of the extension tube.
상기 유입측 하우징(20)의 내면에는 상기 유입통로부(26)와 상기 제1 결합 몸체부(27)의 경계 부근에서 경계벽(244)이 형성되고, 상기 경계벽(244)에는 상기 제1 결합 몸체부(27) 내에 위치하는 상기 밀봉링(40)의 개구(48)와 정렬되는 관통구(28)가 형성된다. 상기 제1 결합 몸체부(27)는 상기 경계벽(244)의 관통구(28)로부터 내경이 확장되면서 단차지게 형성된 원통형의 제1 삽입부(24)와, 상기 제1 삽입부(24)로부터 내경이 확장되면서 단차지게 형성된 원통형의 제2 삽입부(22)를 구비한다. A boundary wall 244 is formed on an inner surface of the inflow side housing 20 near a boundary between the inflow passage 26 and the first coupling body portion 27, and the boundary wall 244 has the first coupling body. A through hole 28 is formed which is aligned with the opening 48 of the sealing ring 40 which is located in the part 27. The first coupling body portion 27 has a cylindrical first insertion portion 24 formed stepwise while the inner diameter thereof is expanded from the through hole 28 of the boundary wall 244, and the inner diameter from the first insertion portion 24. The expansion has a cylindrical second insertion portion 22 formed stepped.
그리고, 상기 제1 결합 몸체부(27) 외주면에는 길이방향을 따라 연장되는 복수개의 산 형태의 돌기부(25)가 형성되어 있다. 본 발명의 모세관 장치(160)의 일실시예에서는 2개의 산 형태의 돌기부(25)가 상기 제1 결합 몸체부(27) 외주면에 형성되어 있고 이들은 서로에 대해 대략 180°의 간격을 두고 떨어져 위치하고 있다. In addition, the outer circumferential surface of the first coupling body portion 27 is provided with a plurality of mountain-shaped protrusions 25 extending in the longitudinal direction. In one embodiment of the capillary device 160 of the present invention, two mountain shaped protrusions 25 are formed on the outer circumferential surface of the first coupling body portion 27 and they are spaced apart from each other at approximately 180 °. have.
또한, 도 2 내지 도 5에 도시된 바와 같이, 상기 유출측 하우징(10)은 상기 내부 공간(32, 33)과 연통되는 유출구(122)를 갖고 있고 상기 유입통로부(26)와 대향되는 위치에 배치되며 상기 내부 공간(32, 33)으로부터 빠져나온 액체를 외부로 이송하는 유출통로부(12)와, 상기 유출통로부(12)와 연통되고 상기 유출통로부(12)로부터 상기 내부 공간(32, 33) 쪽으로 연장되어 형성된 중공형의 제2 결합 몸체부(16)를 구비한다.2 to 5, the outlet side housing 10 has an outlet 122 communicating with the internal spaces 32 and 33 and faces the inlet passage 26. An outlet passage part 12 disposed in the outlet passage 12 for transferring the liquid escaped from the inner spaces 32 and 33 to the outside, and in communication with the outlet passage portion 12, and from the outlet passage portion 12 to the inner space ( 32 and 33, the hollow second coupling body portion 16 is formed.
상기 제2 결합 몸체부(16)는 상기 유출측 하우징(10)을 상기 유입측 하우징(20)에 결합시킬 때, 그 외면이 상기 제1 결합 몸체부(27)의 내면에 밀착되어 끼워지면서 결합된다. 이때, 중공형인 상기 제1 결합 몸체부(27)와 상기 제2 결합 몸체부(16)는 상호 연통되면서 상기 내부 공간(32, 33)을 형성하게 된다(도 5 참조).When the second coupling body portion 16 couples the outlet side housing 10 to the inlet side housing 20, the outer surface of the second coupling body portion 16 closely fits to the inner surface of the first coupling body portion 27 to be coupled thereto. do. At this time, the first coupling body portion 27 and the second coupling body portion 16, which are hollow, communicate with each other to form the internal spaces 32 and 33 (see FIG. 5).
상기 유출측 하우징(10)의 제2 결합 몸체부(16)는 상기 유입측 하우징(20)의 제1 결합 몸체부(27) 내로 밀착되어 끼워지면서 결합될 때, 상기 제2 삽입부(22)에 의해 안내되면서 결합된다. 그리고, 상기 제2 결합 몸체부(16)의 선단(162)은 상기 제1 삽입부(24)와 상기 제2 삽입부(22) 사이에 형성된 단턱부(242)에 맞닿지 않고 여유 공간을 남기게 되는데, 이러한 여유 공간에 밀봉링(40)의 링형상 날개부(42)가 삽입된다.When the second coupling body portion 16 of the outlet side housing 10 is coupled while being fitted in close contact with the first coupling body portion 27 of the inlet side housing 20, the second insertion portion 22 is coupled. Guided by and combined. In addition, the front end 162 of the second coupling body portion 16 does not touch the stepped portion 242 formed between the first insertion portion 24 and the second insertion portion 22 to leave a free space. The ring-shaped wing portion 42 of the sealing ring 40 is inserted into this clearance.
또한, 상기 유출측 하우징(10)은 상기 제2 결합 몸체부(16)에 대해 대향하고 상기 유출통로부(12)의 주위로 일정한 간격을 두고 연장되어 형성된 둘레부(14)를 더 포함한다. 상기 둘레부(14) 내면과 상기 유출통로부(12)의 외면 사이의 공간(142)에는 주사바늘이나 카테터의 결합부(미도시)가 탈착 가능하게 결합할 수 있다.In addition, the outlet side housing 10 further includes a circumferential portion 14 which faces the second coupling body portion 16 and extends at regular intervals around the outlet passage portion 12. A coupling portion (not shown) of the needle or the catheter may be detachably coupled to the space 142 between the inner surface of the circumference portion 14 and the outer surface of the outflow passage portion 12.
추가로, 상기 둘레부(14)의 외주면에는 길이방향으로 연장된 복수개의 돌기부(144)가 형성되어 있다. 상기 둘레부(14)의 외주면에 형성된 복수개의 돌기부(144)와 전술한 상기 제1 결합 몸체부(27)의 외주면에 형성된 복수개의 산 형태의 돌기부(25)는 사용자의 파지를 용이하게 하여 주사바늘이나 카테터의 회동, 분리 및 결합시 사용자의 힘이 원활하게 가해지도록 도와 준다.In addition, a plurality of protrusions 144 extending in the longitudinal direction are formed on the outer circumferential surface of the circumferential portion 14. The plurality of protrusions 144 formed on the outer circumferential surface of the circumferential portion 14 and the plurality of mountain-shaped protrusions 25 formed on the outer circumferential surface of the first coupling body portion 27 described above facilitate the user's gripping. Helps to smoothly apply the user's force when rotating, dismounting and engaging the needle or catheter.
한편, 상기 유입측 하우징(20)과 상기 유출측 하우징(10) 각각은 합성수지 재질, 바람직하게는 ABS(Acrylonitrile Butadiene Styrene copolymer) 수지로 성형한 후, 이들 사이의 접합면(146)에 대해 초음파 접합을 실시하여 결합하도록 구성하는 것이 좋다. 그러나, 본 발명은 이에 제한되는 것이 아니고 본 발명의 목적에 부합되는 당업계에 알려진 다양한 재료를 사용하여 상기 구성요소들을 구성할 수 있음을 본 발명이 속하는 기술분야의 당업자라면 용이하게 이해할 것이다. Meanwhile, each of the inlet housing 20 and the outlet housing 10 is molded of a synthetic resin, preferably ABS (Acrylonitrile Butadiene Styrene copolymer) resin, and then ultrasonically bonded to the bonding surface 146 therebetween. It is good to configure to implement by combining. However, it will be readily understood by those skilled in the art that the present invention is not limited thereto and that the above components may be constructed using various materials known in the art consistent with the object of the present invention.
도 3 및 도 4에 도시된 바와 같이, 상기 모세관(30)은 상기 내부 공간(32, 33) 내의 액체 유동 경로 상에 배치되는데, 구체적으로는 상기 밀봉링(40)과 상기 제2 결합 몸체부(16)에 의해 둘러싸인 공간 내에 배치된다. 이때, 상기 모세관(30)의 액체 유입 측 부분은 상기 밀봉링(40) 내로 밀착삽입되어 수용되고 상기 모세관(30)의 액체 유출 측 부분은 상기 제2 결합 몸체부(16) 내로 삽입되어 수용된다.As shown in FIGS. 3 and 4, the capillary tube 30 is disposed on the liquid flow path in the interior spaces 32 and 33, specifically the sealing ring 40 and the second coupling body portion. It is arranged in the space surrounded by 16. At this time, the liquid inlet side portion of the capillary tube 30 is tightly inserted into the sealing ring 40 and the liquid outlet side portion of the capillary tube 30 is inserted into the second coupling body portion 16 and accommodated therein. .
상기 수용된 모세관(30)은 상기 밀봉링(40)에 의해 액체 유입 측의 뾰족한 단부가 캡핑되면서도 상기 밀봉링(40)의 일측에 형성된 개구(48)를 통해 상기 유입통로부(26)와 연통가능하게 된다. 또한, 상기 수용된 모세관(30)의 액체 유출 측 부분은 상기 제2 결합 몸통부(16) 내로 삽입되면서 상기 제2 결합 몸통부(16)와 연통되어 있는 상기 유출통로부(12)와 연통가능하게 된다. 상기 모세관(30)의 액체 유출 측 말단은 상기 유출통로부(12) 쪽으로 이탈되는 것을 방지하기 위해 상기 제2 결합 몸통부(16)와 상기 유출통로부(12) 사이에 형성된 이탈방지턱(148)에 의해 지지되어 고정된다.The accommodated capillary tube 30 can communicate with the inflow passage 26 through an opening 48 formed at one side of the sealing ring 40 while the pointed end of the liquid inlet side is capped by the sealing ring 40. Done. In addition, the liquid outlet side portion of the accommodated capillary tube 30 is inserted into the second coupling body 16 so as to be in communication with the outlet passage 12 which is in communication with the second coupling body 16. do. The liquid outlet side end of the capillary tube 30 is a separation prevention block 148 formed between the second coupling body portion 16 and the outlet passage portion 12 to prevent the liquid outlet side from being separated toward the outlet passage portion 12. It is supported and fixed by.
도 3, 도 4 및 도 6에 도시된 바와 같이, 상기 밀봉링(40)은 중앙에 개구(48)가 형성된 대략 원통형 몸체부(44)와, 이러한 원통형 몸체부(44)로부터 외경이 확장되면서 단차지게 형성된 링형상 날개부(42)로 구성된다. 상기 밀봉링(40)의 개구(48)의 직경은 안쪽으로 향할수록 점차 좁아지는 테이퍼 형상으로 형성되어 있는데, 상기 개구(48)의 가장 바깥쪽 직경은 상기 경계벽(244)의 관통구(28)의 직경과 거의 동일하도록 구성되어 유입된 액체의 유속을 변화시키지 않고 상기 개구(48)의 가장 안쪽 직경은 상기 모세관(30)의 모서리 부분을 최대한 덮으면서도 상기 모세관(30)의 미세통로를 막지 않도록 구성되어 있어 상기 모세관(30)의 액체 유입 측의 뾰족한 단부를 효율적으로 캡핑할 수 있다. 3, 4 and 6, the sealing ring 40 has a substantially cylindrical body portion 44 having an opening 48 in the center thereof, and the outer diameter thereof extends from the cylindrical body portion 44. It is composed of a ring-shaped wing portion 42 formed stepped. The diameter of the opening 48 of the sealing ring 40 is formed in a tapered shape that gradually narrows toward the inside, and the outermost diameter of the opening 48 is the through hole 28 of the boundary wall 244. The inner diameter of the opening 48 does not block the micropath of the capillary tube 30 while covering the edge of the capillary tube 30 as much as possible without changing the flow velocity of the introduced liquid. It can be configured to efficiently cap the pointed end of the liquid inlet side of the capillary (30).
또한, 상기 원통형 몸체부(44)의 선단 부분의 모서리와 링형상 날개부(42)의 둘레 부분의 모서리는 라운딩처리가 되어 있어, 상기 밀봉링(40)을 캡핑한 모세관(30)을 모세관 장치(160)의 내부, 즉 상기 제1 삽입부(24)로 삽입할 때 상기 모세관(30)의 액체 유입 측의 뾰족한 단부에 의해 모세관 장치(16)의 내부가 긁혀서 이물질이 발생하여 액체 내에 유입되는 것을 방지할 수 있게 된다. In addition, the edge of the tip portion of the cylindrical body portion 44 and the edge of the circumferential portion of the ring-shaped wing portion 42 is rounded, so that the capillary 30 capping the sealing ring 40 capillary device The inside of the capillary device 16 is scratched by the pointed end of the liquid inlet side of the capillary tube 30 when inserted into the first inserting portion 24, that is, foreign matter is generated and introduced into the liquid. Can be prevented.
상기 밀봉링(40)의 원통형 몸체부(44)는 상기 제1 삽입부(24)에 억지끼워맞춤 방식으로 끼워져 결합되고, 상기 밀봉링(40)의 링형상 날개부(42)는 상기 제1 삽입부(24)와 상기 제2 삽입부(22) 사이의 단턱부(242)에 의해 지지된다. 그리고, 상기 밀봉링(40)의 링형상 날개부(42)는 상기 단턱부(242)와 상기 제2 결합 몸체부(16)의 선단(162) 사이의 공간에 끼워져 결합된다. 이때, 상기 모세관(30)의 액체 유출측 말단은 상기 유출통로부(12)를 통해 상기 유출구(122)와는 연통하게 되지만, 상기 모세관(30)의 나머지 부분은 상기 밀봉링(40)과 상기 제2 결합 몸체부(16)의 내벽에 의해 완전히 밀봉되도록 둘러싸이게 된다(도 3 및 도 4 참조). The cylindrical body portion 44 of the sealing ring 40 is fitted and coupled to the first insertion portion 24 in a fitting manner, the ring-shaped wing portion 42 of the sealing ring 40 is the first It is supported by the stepped portion 242 between the insertion portion 24 and the second insertion portion 22. In addition, the ring-shaped wing portion 42 of the sealing ring 40 is fitted into the space between the stepped portion 242 and the tip 162 of the second coupling body portion 16 is coupled. At this time, the liquid outlet side end of the capillary tube 30 is in communication with the outlet 122 through the outlet passage portion 12, the remaining portion of the capillary tube 30 is the sealing ring 40 and the first 2 is enclosed so as to be completely sealed by the inner wall of the engaging body portion 16 (see FIGS. 3 and 4).
한편, 상기 밀봉링(40)은 상기 모세관(30) 주위의 공간을 효과적으로 밀봉하고 상기 제1 삽입부(24) 등에 밀착되어 끼워져 결합될 수 있도록 실리콘 재질로 구성하는 것이 바람직하다. 그러나, 본 발명은 이에 제한되는 것이 아니고 본 발명의 목적에 부합되는 당업계에 알려진 다양한 재료를 사용하여 상기 구성요소를 구성할 수 있음을 본 발명이 속하는 기술분야의 당업자라면 용이하게 이해할 것이다. On the other hand, the sealing ring 40 is preferably made of a silicon material so as to effectively seal the space around the capillary tube 30, the first inserting portion 24 and the like to be coupled and coupled. However, it will be readily understood by those skilled in the art that the present invention is not limited thereto and that the above components may be constructed using various materials known in the art consistent with the object of the present invention.
도 2 내지 도 4에 도시된 바와 같이 상기 유입구(29)를 통해 유입된 액체의 고체 불순물을 걸러내고 여과된 액체는 상기 모세관(30)으로 유입시키는 친수성 내부 필터는 상기 유입구(29)와 상기 모세관(30) 사이의 공간에 위치한다. 구체적으로, 상기 친수성 내부 필터는 상기 경계벽(244)과 상기 밀봉링(40) 외면 사이에 설치되는 필터(50)(이하, "A 필터"라고 함), 상기 유입통로부(26) 내에서 상기 경계벽(244) 상에 설치되는 필터(51)(이하, "B 필터"라고 함) 및 상기 밀봉링(40) 내면과 상기 모세관(30)의 액체 유입 측 사이에 설치되는 필터(52)(이하, "C 필터"라고 함) 중 적어도 하나를 포함할 수 있다.As shown in FIGS. 2 to 4, a hydrophilic internal filter that filters out solid impurities of the liquid introduced through the inlet port 29 and introduces the filtered liquid into the capillary tube 30 has the inlet port 29 and the capillary tube. Located in the space between 30. Specifically, the hydrophilic inner filter is a filter 50 (hereinafter referred to as “A filter”) installed between the boundary wall 244 and the outer surface of the sealing ring 40 and the inflow passage 26. Filter 51 (hereinafter referred to as "B filter") provided on the boundary wall 244 and filter 52 (hereinafter referred to as "between" the inner surface of the sealing ring 40 and the liquid inflow side of the capillary tube 30) , “C filter”).
예를 들어, 도 3에는 1개의 친수성 내부 필터(50)가 상기 경계벽(244)과 상기 밀봉링(40) 외면 사이에 설치된 일례가 도시되어 있고, 도 4에는 전술한 바와 같은 3개의 친수성 내부 필터(50, 51, 52)가 모두 설치된 일례가 도시되어 있다. 뿐만아니라 도면에는 도시하지 않았으나, B 필터나 C 필터가 단독으로 설치될 수 있으며, A 필터와 B 필터의 조합, A 필터와 C 필터의 조합 그리고 B 필터와 C 필터의 조합으로도 설치될 수 있다. For example, FIG. 3 shows an example in which one hydrophilic inner filter 50 is installed between the boundary wall 244 and the outer ring 40, and in FIG. 4, three hydrophilic inner filters as described above. An example in which all of 50, 51, and 52 are provided is shown. In addition, although not shown in the drawings, a B filter or a C filter may be installed alone, and may be installed as a combination of A filter and B filter, a combination of A filter and C filter, and a combination of B filter and C filter. .
그러나, 본 발명에 있어서 상기 친수성 내부 필터(50, 51, 52)의 설치 위치는 상기와 같은 예시에만 한정되는 것이 아니며, 상기 유입구(29)를 통해 유입된 액체의 고체 불순물을 효과적으로 여과하는 곳이라면 상기 유입구(29)와 상기 모세관(30) 사이의 공간 내에서 상기 친수성 내부 필터(50, 51, 52)를 설치할 수 있으며 설치 수량도 조절가능하다. However, in the present invention, the installation positions of the hydrophilic internal filters 50, 51, and 52 are not limited to the above examples, provided that the solid impurities of the liquid introduced through the inlet port 29 are effectively filtered. The hydrophilic internal filter 50, 51, 52 can be installed in the space between the inlet 29 and the capillary 30, and the installation quantity can be adjusted.
기능적인 측면에서, 상기 친수성 내부 필터(50, 51, 52)는 외부 필터장치(150)에 의한 1차 여과 후에도 유동하는 액체 내에 포함될 수 있는 각종 불순물을 모세관(30) 유입 직전에 제거함으로써 불순물의 모세관 유입에 의한 액체 주입 중단 또는 액체 주입량의 저하 문제를 사전에 방지할 수 있다(도 7 참조). In functional terms, the hydrophilic inner filter 50, 51, 52 removes various impurities that may be included in the flowing liquid even after primary filtration by the external filter device 150, immediately before the capillary 30 inflow. The problem of interrupting liquid injection or lowering the liquid injection amount due to capillary inflow can be prevented in advance (see FIG. 7).
예를 들어, 도 7에 도시된 바와 같이 국제공개특허공보 WO 2010/120051 A2호에 도시된 주사액 주입장치(100)에 본 발명의 모세관 장치(160)를 적용할 수 있다. 상기 주사액 주입장치(100)의 약물 펌핑이 시작되면, 피스톤(140)의 후방에 배치된 기체공급부(130)로부터 발생된 기체는 상기 피스톤(140)을 전방으로 밀어주게 되고 실린더(110)내의 약물저장공간(120)에 저장된 약물은 상기 피스톤(140)에 의해 일정한 유량으로 유동튜브(151)로 밀려나오게 된다. 상기 약물저장공간(120)으로부터 상기 유동튜브(151)로 유동하는 약물에 포함된 고체 파티클과 같은 불순물과 공기와 같은 기체는 외부 필터장치(150)에 제공된 친수성 필터와 소수성 필터에 의하여 1차적으로 제거된다. For example, the capillary device 160 of the present invention can be applied to the injection liquid injection device 100 shown in WO 2010/120051 A2 as shown in FIG. 7. When the drug pumping of the injection liquid injection device 100 starts, gas generated from the gas supply unit 130 disposed behind the piston 140 pushes the piston 140 forward and the drug in the cylinder 110. The drug stored in the storage space 120 is pushed out to the flow tube 151 at a constant flow rate by the piston 140. Impurities such as solid particles and gas, such as air, contained in the drug flowing from the drug storage space 120 to the flow tube 151 are primarily by a hydrophilic filter and a hydrophobic filter provided to the external filter device 150. Removed.
그러나, 상기 외부 필터장치(150)에 의한 1차 여과 후에도 상기 외부 필터장치(150)와 상기 모세관 장치(160)의 사이에는 새로운 오염물이 존재할 수 있다. 예를 들어, 연장튜브(152) 내부에 존재하는 입자 및 기타 오염원, 상기 외부 필터장치(150)와 상기 연장튜브(152)를 연결할 때 사용하는 접착제 성분, 상기 연장튜브(152)와 상기 모세관 장치(160)를 연결하는데 사용하는 접착제 성분, 그리고 약물의 특성에 따른 침전물이 존재할 수 있다. 전술한 바와 같은 본 발명의 모세관 장치(160)에 제공된 A 필터, B 필터 및/또는 C 필터는 상기와 같은 불순물들을 모세관(30) 유입 전에 걸러내어 이들 불순물들이 모세관(30)을 막거나 좁아지게 하는 바람직하지 않은 현상을 사전에 방지할 수 있다. However, new contaminants may exist between the external filter device 150 and the capillary device 160 even after the first filtration by the external filter device 150. For example, particles and other contaminants present in the extension tube 152, an adhesive component used to connect the external filter device 150 and the extension tube 152, the extension tube 152 and the capillary device There may be an adhesive component used to connect 160 and a precipitate depending on the nature of the drug. The A filter, B filter and / or C filter provided in the capillary device 160 of the present invention as described above filters such impurities before entering the capillary 30 so that these impurities block or narrow the capillary 30. Undesirable phenomenon can be prevented in advance.
한편, 상기 친수성 내부 필터(50, 51, 52)로는 고체 불순물을 걸러내고 액체를 통과시키는 것으로서 당업계에 널리 알려져 있고 통상 구입이 가능한 것이라면 어느 것이라도 사용이 가능하다. 일례로서 상기 친수성 내부 필터(50, 51, 52)의 공극 크기는 약 30㎛ 내지 50㎛일 수 있으나, 본 발명은 이에 제한되는 것이 아니고 고체 불순물의 크기에 따라 적절한 크기의 공극을 가진 필터를 사용할 수 있음은 물론이다.On the other hand, the hydrophilic inner filter (50, 51, 52) can be used as long as it is well known in the art and usually available as a filter to filter out the solid impurities and pass through the liquid. For example, the pore size of the hydrophilic inner filter 50, 51, 52 may be about 30 μm to 50 μm, but the present invention is not limited thereto, and a filter having a pore having an appropriate size may be used according to the size of solid impurities. Of course it can.
이상 본 발명을 상기 실시예를 들어 설명하였으나, 본 발명은 이에 제한되는 것은 아니다. 당업자라면, 본 발명의 취지 및 범위를 벗어나지 않고 수정, 변경을 할 수 있으며 이러한 수정과 변경 또한 본 발명에 속하는 것임을 알 수 있을 것이다. Although the present invention has been described with reference to the above embodiments, the present invention is not limited thereto. Those skilled in the art will appreciate that modifications and variations can be made without departing from the spirit and scope of the present invention and that such modifications and variations also fall within the present invention.

Claims (3)

  1. 액체 공급라인에 연결되는 모세관 장치에 있어서,In a capillary device connected to a liquid supply line,
    액체가 유동하는 액체 공급라인과 연결되는 유입구를 갖고 있고 상기 유입구를 통해 유입된 액체를 모세관 장치의 내부 공간으로 유동시키는 유입통로부와, 상기 유입통로부와 연통되고 상기 유입통로부로부터 상기 내부 공간 쪽으로 연장되어 형성된 중공형의 제1 결합 몸체부를 구비하는 유입측 하우징과,An inlet passage having an inlet connected to a liquid supply line through which the liquid flows, and an inflow passage for flowing the liquid introduced through the inlet into an inner space of the capillary device, and in communication with the inflow passage and from the inflow passage; An inlet-side housing having a hollow first engaging body portion extending toward one another;
    상기 내부 공간과 연통되는 유출구를 갖고 있고 상기 유입통로부와 대향되는 위치에 배치되며 상기 내부 공간으로부터 빠져나온 액체를 외부로 이송하는 유출통로부와, 상기 유출통로부와 연통되고 상기 유출통로부로부터 상기 내부 공간 쪽으로 연장되어 형성된 중공형의 제2 결합 몸체부로서, 상기 제1 결합 몸체부와 연통되면서 결합되어 상기 내부 공간을 형성하는 제2 결합 몸체부를 구비하는 유출측 하우징과,An outlet passage portion having an outlet port communicating with the inner space and disposed at a position opposite to the inlet passage portion, and configured to transfer the liquid exiting from the inner space to the outside; and an outlet passage portion communicating with the outlet passage portion and from the outlet passage portion. A hollow second coupling body portion extending toward the inner space, the outlet side housing having a second coupling body portion coupled to communicate with the first coupling body portion to form the inner space;
    상기 내부 공간 내의 액체 유동 경로 상에 배치되는 모세관과,A capillary tube disposed on the liquid flow path in the interior space;
    상기 모세관의 액체 유입 측의 뾰족한 단부를 캡핑하고, 상기 내부 공간에서 상기 모세관 주위의 공간을 밀봉하되 상기 유입통로부로부터의 액체가 상기 모세관을 통해 상기 유출통로부로 유동가능하도록 일측에 개구가 형성된 밀봉링과,Capping the sharp end of the capillary liquid inlet side and sealing the space around the capillary tube in the inner space but having an opening formed at one side such that liquid from the inflow passage portion can flow through the capillary tube to the outlet passage portion Rings,
    상기 유입구와 상기 모세관 사이의 공간에 위치하고, 상기 유입구를 통해 유입된 액체의 고체 불순물을 걸러내고 여과된 액체는 상기 모세관으로 유입시키는 적어도 하나의 친수성 내부 필터를 포함하는 내부 필터를 구비한 모세관 장치.And a capillary device disposed in the space between the inlet and the capillary, the filter comprising at least one hydrophilic internal filter to filter out solid impurities of the liquid introduced through the inlet and to introduce the filtered liquid into the capillary.
  2. 제1항에 있어서,The method of claim 1,
    상기 유입측 하우징의 내면에는 상기 유입통로부와 상기 제1 결합 몸체부의 경계에서 경계벽이 형성되고, 상기 경계벽에는 상기 제1 결합 몸체부 내에 위치하는 상기 밀봉링의 개구와 정렬되는 관통구가 형성되며,A boundary wall is formed on an inner surface of the inflow side housing at a boundary between the inflow passage portion and the first coupling body portion, and the throughwall is formed at the boundary wall to align with an opening of the sealing ring located in the first coupling body portion. ,
    상기 친수성 내부 필터는 상기 유입통로부 내에서 상기 경계벽 상에 설치되는 필터, 상기 경계벽과 상기 밀봉링 외면 사이에 설치되는 필터, 및 상기 밀봉링 내면과 상기 모세관의 액체 유입측 사이에 설치되는 필터로 구성된 군으로부터 선택되는 적어도 하나인 것을 특징으로 하는 내부 필터를 구비한 모세관 장치.The hydrophilic inner filter may be a filter installed on the boundary wall in the inflow passage, a filter installed between the boundary wall and the sealing ring outer surface, and a filter installed between the sealing ring inner surface and the liquid inflow side of the capillary tube. Capillary device with internal filter, characterized in that at least one selected from the group consisting of.
  3. 제2항에 있어서,The method of claim 2,
    상기 유입측 하우징의 제1 결합 몸체부는 상기 경계벽의 관통구로부터 내경이 확장되면서 단차지게 형성된 원통형의 제1 삽입부와, 상기 제1 삽입부로부터 내경이 확장되면서 단차지게 형성된 원통형의 제2 삽입부를 구비하고,The first coupling body of the inlet-side housing is a cylindrical first insertion portion formed stepped while the inner diameter is extended from the through hole of the boundary wall, and a cylindrical second insertion portion formed stepped while the inner diameter is extended from the first insertion portion. Equipped,
    상기 유출측 하우징의 제2 결합 몸체부는 상기 제2 삽입부에 의해 안내되면서 상기 유입측 하우징의 제1 결합 몸체부 내로 결합될 때, 상기 제2 결합 몸체부의 선단이 상기 제1 삽입부와 상기 제2 삽입부 사이에 형성된 단턱부에 맞닿지 않으며,When the second coupling body portion of the outflow side housing is guided by the second insertion portion and coupled into the first coupling body portion of the inflow side housing, the front end of the second coupling body portion is coupled to the first insertion portion and the first insertion portion. 2 does not touch the stepped portion formed between the inserts,
    상기 밀봉링은 중앙에 개구가 형성된 원통형 몸체부와, 이러한 원통형 몸체부로부터 외경이 확장되면서 단차지게 형성된 링형상 날개부로 구성되고, 상기 원통형 몸체부의 선단 부분의 모서리와 상기 링형상 날개부의 둘레 부분의 모서리는 라운딩처리가 되어 있으며, The sealing ring is composed of a cylindrical body portion having an opening in the center, and a ring-shaped wing portion formed stepped while the outer diameter thereof is expanded from the cylindrical body portion, and the edge of the tip portion of the cylindrical body portion and the circumferential portion of the ring-shaped wing portion. The corners are rounded
    상기 밀봉링의 원통형 몸체부는 상기 제1 삽입부에 억지끼워맞춤 방식으로 끼워져 결합되고, 상기 밀봉링의 링형상 날개부는 상기 제1 삽입부와 상기 제2 삽입부 사이의 단턱부에 의해 지지되면서 상기 단턱부와 상기 제2 결합 몸체부의 선단 사이의 공간에 끼워져 결합되는 것을 특징으로 하는 내부 필터를 구비한 모세관 장치.The cylindrical body portion of the sealing ring is fitted and coupled to the first insertion portion in a fitting manner, and the ring-shaped wing portion of the sealing ring is supported by the step portion between the first insertion portion and the second insertion portion, Capillary device having an internal filter, characterized in that coupled to the space between the stepped portion and the front end of the second coupling body portion.
PCT/KR2014/007421 2013-09-10 2014-08-11 Capillary device comprising internal filter, and injection fluid injection device comprising same WO2015037832A1 (en)

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