JPH01135359A - Controller for feeding small amount of fluid - Google Patents

Controller for feeding small amount of fluid

Info

Publication number
JPH01135359A
JPH01135359A JP63122737A JP12273788A JPH01135359A JP H01135359 A JPH01135359 A JP H01135359A JP 63122737 A JP63122737 A JP 63122737A JP 12273788 A JP12273788 A JP 12273788A JP H01135359 A JPH01135359 A JP H01135359A
Authority
JP
Japan
Prior art keywords
filter
flow rate
fluid
control device
capillary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63122737A
Other languages
Japanese (ja)
Inventor
Hajime Tsujikawa
辻川 肇
Toshiki Yoshida
俊樹 吉田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissho Corp
Original Assignee
Nissho Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissho Corp filed Critical Nissho Corp
Priority to JP63122737A priority Critical patent/JPH01135359A/en
Publication of JPH01135359A publication Critical patent/JPH01135359A/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C04CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04BLIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B24/00Use of organic materials as active ingredients for mortars, concrete or artificial stone, e.g. plasticisers
    • C04B24/04Carboxylic acids; Salts, anhydrides or esters thereof
    • C04B24/045Esters, e.g. lactones
    • CCHEMISTRY; METALLURGY
    • C04CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04BLIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2103/00Function or property of ingredients for mortars, concrete or artificial stone
    • C04B2103/30Water reducers, plasticisers, air-entrainers, flow improvers
    • C04B2103/34Flow improvers

Abstract

PURPOSE:To make long-time continuous feeding possible by regulating the flow rate of an infusion fluid with a filter and further with a capillary. CONSTITUTION:A controller 1 for feeding small amount of infusion fluid includes a layered filter 2 and a capillary 3 which are contained in a housing 5. An air-vent filter is preferably provided above the filter 2. The flow rate of the infusion fluid is first regulated with the filter 2 and then with the capillary 3. Since the fluid first passes through the filter 2, pores 4 of the capillary 3 are kept from being blocked by foreign substances in the fluid.

Description

【発明の詳細な説明】 〈産業上の利用分野〉 本発明は微量送液の制御装置に関するものであり、特に
、所定量の薬液を血管、膀胱などに少しずつ持続して注
入するなめに用いられるバルーンインフユーザに好適に
適用される。
[Detailed Description of the Invention] <Industrial Application Field> The present invention relates to a control device for feeding a small amount of liquid, and is particularly used for continuously injecting a predetermined amount of a medicinal liquid into a blood vessel, bladder, etc. It is suitable for balloon inflatable users.

〈従来の技術〉 従来より、抗生物質や抗ガン剤などの薬液を血管、膀胱
などに微量に注入する手段として、弾性材料からなるバ
ルーンに薬液を注入し、該バルーンの収縮力を利用して
薬液を比較的長時間にわたって血管内などに持続注入す
るバルーン付き薬液持続注入器が提案されている(たと
えば特開昭62−11465号公報、特願昭62−20
4791号)。
<Conventional technology> Conventionally, as a means of injecting small amounts of medicinal solutions such as antibiotics and anticancer drugs into blood vessels, bladders, etc., the medicinal solution is injected into a balloon made of an elastic material and the contraction force of the balloon is utilized. A continuous drug injector with a balloon that continuously injects a drug solution into a blood vessel or the like over a relatively long period of time has been proposed (for example, Japanese Patent Application Laid-Open No. 11465/1982, Japanese Patent Application No. 1987-20
No. 4791).

これらのバルーン付き薬液持続注入器(以下、バルーン
インフユーザという)における薬液流量の調節は、特開
昭62−11465号公報の発明においては主として流
量調節弁で行われており、また特願昭62−20479
1号の発明ではバイブの側部に形成された微細孔によっ
て行われている。
Adjustment of the drug flow rate in these balloon-equipped continuous drug injectors (hereinafter referred to as balloon infuser) is mainly performed using a flow rate control valve in the invention disclosed in Japanese Patent Application Laid-open No. 11465/1982, and -20479
In the invention No. 1, this is done by using micro holes formed on the side of the vibrator.

しかしながら、これらの流量制御手段を用いた従来のバ
ルーンインフユーザでは、流量を制御できる時間は、6
0CCの薬液を注入するのにせいぜい24時間程度であ
り、更に長時間の持続輸液、たとえば60ccの薬液を
3日間とか1週間とか持続的に少量ずつ注入する場合、
に対応できるものではなかった。
However, in conventional balloon inflator users using these flow rate control means, the time during which the flow rate can be controlled is 6
It takes about 24 hours at most to inject 0 cc of a drug solution, and when injecting a long-term continuous infusion, for example, 60 cc of a drug solution is continuously injected in small amounts for 3 days or 1 week,
It was not something that could be addressed.

〈発明が解決しようとする問題点〉 本発明は上記の問題点を解決するためになされたもので
、従来のものよりはるかに長時間のバルーンインフユー
ザによる持続輸液を可能とする微量送液の制御装置を提
供することを目的とする。
<Problems to be Solved by the Invention> The present invention has been made to solve the above-mentioned problems, and is a micro-volume fluid delivery system that enables continuous infusion using a balloon infuser for a much longer period of time than conventional systems. The purpose is to provide a control device.

〈問題点を解決するための手段〉 本発明は上記の問題点を解決するもので、多孔質ガラス
、焼結金属、ポリマー焼結体の群から選ばれる材料から
形成されてなる層状のフィは先端の閉鎖部分に少なくと
も1個の微細孔が穿設されていることを特徴とする微量
送液の制御装置に関する。
<Means for Solving the Problems> The present invention solves the above problems, and includes a layered film made of a material selected from the group of porous glass, sintered metal, and polymer sintered body. The present invention relates to a control device for feeding a small amount of liquid, characterized in that at least one fine hole is bored in the closed portion of the tip.

〈作用〉 本発明によればフィルタで液体の流量が制限された後、
さらに細管で液体流量が制限される。
<Operation> According to the present invention, after the flow rate of liquid is restricted by the filter,
Furthermore, the liquid flow rate is restricted by the capillary.

従って流量調節弁や、側部に微細孔の形成されたパイプ
のみで流量を調節していた従来のバルーンインフユーザ
に比べて、本発明の微量送液の制御装置を採用したバル
ーンインフユーザは、はるかに長時間の持続輸液が可能
である。
Therefore, compared to conventional balloon infuser users who adjust the flow rate only with a flow rate control valve or a pipe with micro holes formed on the side, balloon infuser users who have adopted the control device for micro-volume liquid delivery of the present invention can: Continuous infusion for a much longer period of time is possible.

〈実施例〉 次に図面に基づいて本発明の微量送液の制御装置を説明
する。
<Example> Next, a micro-liquid feeding control device of the present invention will be described based on the drawings.

第1図は本発明の一実施例に係る微量送液の制御装置を
示す図であり(長手軸における断面図)、第2図は第1
図の制御装置にエアベントフィルタを接続したものを示
す図、第3図は第2図のものと類似の制御装置を用いた
バルーンインフユーザを示す図である。
FIG. 1 is a diagram showing a micro-liquid feeding control device according to an embodiment of the present invention (a cross-sectional view along the longitudinal axis), and FIG.
FIG. 3 is a diagram showing a balloon inflator using a control device similar to that shown in FIG. 2; FIG.

本発明の微量送液の制御装置(1)は、第1図に示すよ
うに層状のフィルタ(2)と細管(3)とから構成され
ており、ハウジング(5)に収納されている。
As shown in FIG. 1, the micro-liquid feeding control device (1) of the present invention is comprised of a layered filter (2) and a thin tube (3), and is housed in a housing (5).

そして好ましくは第2図に示すように、フィルタ(2)
の上流にエアベントフィルタ(8)が接続される。
and preferably a filter (2) as shown in FIG.
An air vent filter (8) is connected upstream of the air vent filter (8).

フィルタ(2)は細管(3)の上流側に配置されて薬液
の流量を制限するもので、細管(3)の上流側に配置さ
れることにより、薬液中の異物などが細管(3)に達し
て、その微細孔(4)を塞いでしまうことを防いでいる
The filter (2) is placed on the upstream side of the thin tube (3) to restrict the flow rate of the chemical solution.By being placed on the upstream side of the thin tube (3), the filter (2) prevents foreign substances in the chemical liquid from entering the thin tube (3). This prevents the micropores (4) from reaching the micropores (4).

フィルタ(2)の形成材料としては、多孔質ガラスや焼
結金属、ポリマー焼結体などが使用可能であり、一般に
焼結される金属としてはたとえば鉄、ステンレス、モリ
ブデン、黄銅などが、焼結されるポリマーとしてはポリ
プロピレンやポリエチレンなどが使用される。
As the material for forming the filter (2), porous glass, sintered metal, polymer sintered body, etc. can be used. Examples of metals that are generally sintered include iron, stainless steel, molybdenum, brass, etc. Polypropylene, polyethylene, etc. are used as the polymer.

フィルタ(2)の形状は特に限定されるものではないが
、第1図に示すような有底筒状や、ハウジング(5)の
形状に合わせた形状の例えば円柱状などが一般的であり
、層状に形成される。第1図においては細管(3)が有
底筒状物に形成された層状のフィルタ(2)に収容され
るように配置されている。
The shape of the filter (2) is not particularly limited, but generally has a bottomed cylindrical shape as shown in FIG. 1, or a cylindrical shape that matches the shape of the housing (5). Formed in layers. In FIG. 1, a thin tube (3) is arranged so as to be accommodated in a layered filter (2) formed in a cylindrical body with a bottom.

フィルタ(2)の孔径は細管(3)に形成された微細孔
(4)の孔径よりも小さく、10μm以下、好ましくは
0.1〜3μmに形成される。
The pore diameter of the filter (2) is smaller than the pore diameter of the micropores (4) formed in the thin tube (3), and is 10 μm or less, preferably 0.1 to 3 μm.

細管(3)は前記フィルタ(2)で流量を制限された薬
液を受けて、さらにその流量を制限するためのもので、
その側壁には少なくとも1箇以上の微細孔(4)が穿設
されている。
The thin tube (3) is for receiving the chemical liquid whose flow rate has been restricted by the filter (2) and further restricting the flow rate.
At least one or more fine holes (4) are bored in the side wall.

微細孔(4)の孔径を小さくするほどこの孔を通過する
薬液の流体抵抗が大きくなるわけであるが、孔径は薬液
の種類や流量などに応じて適宜選定される。本発明にお
いては特に限定されるものではないが概ね20〜100
μmが目安である。
The smaller the diameter of the micropores (4), the greater the fluid resistance of the chemical liquid passing through the hole, and the hole diameter is appropriately selected depending on the type of chemical liquid, the flow rate, etc. In the present invention, although not particularly limited, approximately 20 to 100
The standard is μm.

微細孔(4)の数は薬液の流量によっては1個形成する
だけで正確に流量を制御できる場合もあるが、流量の正
確な制御という点、とくに高粘度の薬液を使用する場合
の流量制御を考慮した場合、一般的にはできるだけ微小
な孔を複数個形成するようにするのが好ましい。
Depending on the flow rate of the chemical solution, it may be possible to accurately control the flow rate by forming only one micropore (4), but it is difficult to control the flow rate accurately, especially when using a highly viscous chemical solution. In consideration of this, it is generally preferable to form a plurality of holes as small as possible.

細管(3)の形成材料としては耐薬品性、加工性、無毒
性などの点からステンレス鋼が好ましいが、前記した特
性を有するものであれば他の材料でも良く、合成樹脂の
たとえばポリカーボネート、ポリプロピレン、アクリロ
ニトリルブタジェンスチレン共重合体などを用いること
もできる。
Stainless steel is preferred as the material for forming the thin tube (3) from the viewpoint of chemical resistance, workability, non-toxicity, etc., but other materials may be used as long as they have the above-mentioned characteristics, and synthetic resins such as polycarbonate and polypropylene may be used. , acrylonitrile butadiene styrene copolymer, etc. can also be used.

ハウジング(5)は液体流入口(6)と液体流出口(力
を有する中空の容器であり、内部に前記のフィルタ(2
)および細管(3)が収容されている。
The housing (5) is a hollow container with a liquid inlet (6) and a liquid outlet (power), and has the filter (2) inside.
) and a capillary (3) are accommodated.

ハウジング(5)の形成材料としては、特に限定される
わけではないが一般に合成樹脂などが使用される。
Although the material for forming the housing (5) is not particularly limited, synthetic resin and the like are generally used.

エアベントフィルタ(8)ハ、薬液がフィルタ(2)を
透過するときに生ずる、いわゆるエアブロツク現象(薬
液中に気泡が混在していると、微細孔を満たす薬液の表
面張力のために空気が該微細孔内に進行することができ
ず、こういった微細孔の入口付近に停滞している空気に
よって薬液の流れが妨げられる現象)によって薬液の流
れが妨げられることを防止すべく配置されるもので、た
とえば第2図に示すような、短円柱状の空間により構成
された空気抜き部(9)の該短円柱の片面に疎水性フィ
ルタからなる膜状のフィルタ(透明に描かれているので
図面には表われていない)が設けられたものが、好適に
使用しつる。ここで(10)は板状の邪魔板であり、膜
状のフィルタふ・よび短円柱状空間を構成するエアベン
トフィルタ(8)の底面に接するように空気抜き部(9
)内に設けられている。
Air vent filter (8) C: The so-called air block phenomenon occurs when the chemical solution passes through the filter (2) (if air bubbles are present in the chemical solution, the surface tension of the chemical solution filling the micropores causes the air to flow through the micropores). It is arranged to prevent the flow of chemical solution from being obstructed by air that cannot advance into the pores and is stagnant near the entrance of these micropores. For example, as shown in FIG. 2, an air vent part (9) consisting of a short cylindrical space has a membrane-like filter made of a hydrophobic filter on one side of the short cylindrical space (as it is drawn transparently, it cannot be seen in the drawing). (not shown) is preferably used. Here, (10) is a plate-shaped baffle plate, and the air vent part (9) is in contact with the bottom surface of the air vent filter (8) that constitutes the membrane filter pipe and the short cylindrical space.
).

薬液は第2図において矢印で示すようにS字状に進むた
め、気泡を含有する薬液が流下する間に気泡が膜状のフ
ィルタを通って外部に排出される。
Since the chemical liquid advances in an S-shape as shown by the arrow in FIG. 2, while the chemical liquid containing air bubbles flows down, the air bubbles are discharged to the outside through the membrane filter.

膜状のフィルタとエアベントフィルタ(8)の底面との
間隔は、小さな気泡も確実に膜状のフィルタに接するよ
うにできるだけ狭く形成されており、好ましくは0.0
5〜1.0朋であり、とくに0.1〜0.5朋であるの
が好ましい。
The distance between the membrane filter and the bottom of the air vent filter (8) is made as narrow as possible to ensure that even small air bubbles come into contact with the membrane filter, and is preferably 0.0
5 to 1.0, particularly preferably 0.1 to 0.5.

尚、邪魔板q■の配置は薬液が容易に下流のフィルタ(
2)に到達しないようなものであればよく、第2図に示
されるものに限定されない。また膜状のフィルタの形状
および空気抜き部(9)の形状も本実施例のものに限定
されることはなく、適宜選定すればよい。
In addition, the arrangement of the baffle plate q allows the chemical solution to easily pass through the downstream filter (
2), and is not limited to that shown in FIG. 2. Further, the shape of the membrane filter and the shape of the air vent (9) are not limited to those of this embodiment, and may be selected as appropriate.

次に本発明の制御装置を使用したバルーンインフユーザ
の使用方法について説明する。
Next, a method of using a balloon inflator using the control device of the present invention will be described.

第3図において(6)はバルーン部、(B)は流量制御
部、(C)は薬液注入チューブ、(9)は接続具である
In FIG. 3, (6) is a balloon part, (B) is a flow rate control part, (C) is a chemical liquid injection tube, and (9) is a connector.

薬液の注入は、突出部αaの先端から注射器の注射針(
図示せず)などを挿入し、該注射針を薬液注入用栓体(
図示せず)に刺しこんで行われる。薬液を充填するにつ
れて、バルーン(1旧よ半径方向とともに軸方向へも膨
脹する。所定の量の薬液の充填が終わると、注射針を薬
液注入用栓体から抜き取る。その際、万一薬液が薬液注
入用栓体の蓋部(図示せず)に付着したとしても、該蓋
部は奥まっkところに配置されているので、この薬液に
操作者が手などを触れてしまうというようなことがない
To inject the drug solution, insert the needle of the syringe (
(not shown), etc., and insert the injection needle into a drug solution injection stopper (not shown).
(not shown). As the drug solution is filled, the balloon (1) expands in both the radial and axial directions. When the predetermined amount of drug solution is filled, the syringe needle is removed from the drug injection stopper. Even if it adheres to the lid (not shown) of the drug solution injection stopper, the lid is located at the far end, so there is no possibility that the operator will touch the drug solution with his or her hands. do not have.

つぎに、流量制御部(B)の薬液注入針Q6)を薬液注
入用栓体に刺しこむ。その際薬液がチューブ(0の方へ
流出しないようにミニクランプα印を停止の状態にして
おく必要がある。
Next, the drug solution injection needle Q6) of the flow rate control unit (B) is inserted into the drug solution injection stopper. At this time, it is necessary to keep the mini clamp α mark in a stopped state so that the chemical solution does not flow out toward the tube (0).

その後は実際の薬液注入箇所に応じて接続具を介して静
脈留置カテーテルなどに接続し、患者の体内に薬液の注
入が行われる。
Thereafter, it is connected to an intravenous indwelling catheter or the like via a connector depending on the actual location where the drug solution is to be injected, and the drug solution is injected into the patient's body.

〈発明の効果〉 以上説明してきたことから明らかなようにζ、本発明の
微量送液の制御装置を採用すれば、非常に長時間の持続
輸液を行うことができる。
<Effects of the Invention> As is clear from the above explanation, by employing the control device for feeding a small amount of liquid according to the present invention, continuous infusion can be performed for a very long time.

また、細管の微細孔の大きさおよび数を適当に変えるこ
とによって持続輸液の時間を容易に選択することができ
る。
In addition, the duration of continuous infusion can be easily selected by appropriately changing the size and number of micropores in the capillary.

【図面の簡単な説明】[Brief explanation of the drawing]

第1図は本発明の実施例を示す図であり、第2図はl1
図の制御装置にエアベントフィルタを接続したものを示
す図、第3図は第2図のものと類似の制御装置を用いた
バルーンインフユーザを示す図である。 く主な符号の説明〉 1:制御装置    2:フィルタ 3:細管      4:微細孔 5:ハウジング 6:液体流入口
FIG. 1 is a diagram showing an embodiment of the present invention, and FIG. 2 is a diagram showing an embodiment of the present invention.
FIG. 3 is a diagram showing a balloon inflator using a control device similar to that shown in FIG. 2; FIG. Explanation of main symbols> 1: Control device 2: Filter 3: Thin tube 4: Fine hole 5: Housing 6: Liquid inlet

Claims (1)

【特許請求の範囲】 1)多孔質ガラス、焼結金属、ポリマー焼結体の群から
選ばれる材料から形成されてなる層状のフィルタの下流
に、先端の閉鎖された金属製の細管が接続されてなり、
該細管の側壁および/または先端の閉鎖部分に少なくと
も1個の微細孔が穿設されていることを特徴とする微量
送液の制御装置。 2)フィルタの上流にエアベントフィルタを接続してな
る特許請求の範囲第1項記載の制御装置。 3)フィルタの孔径が0.1〜3ミクロンである特許請
求の範囲第1項記載の制御装置。
[Claims] 1) A thin metal tube with a closed tip is connected downstream of a layered filter made of a material selected from the group of porous glass, sintered metal, and polymer sintered body. Then,
A control device for micro-liquid feeding, characterized in that at least one microhole is bored in the side wall and/or the closed portion of the tip of the capillary. 2) The control device according to claim 1, comprising an air vent filter connected upstream of the filter. 3) The control device according to claim 1, wherein the filter has a pore diameter of 0.1 to 3 microns.
JP63122737A 1988-05-19 1988-05-19 Controller for feeding small amount of fluid Pending JPH01135359A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63122737A JPH01135359A (en) 1988-05-19 1988-05-19 Controller for feeding small amount of fluid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63122737A JPH01135359A (en) 1988-05-19 1988-05-19 Controller for feeding small amount of fluid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP62294809A Division JPH0687896B2 (en) 1987-06-18 1987-11-20 Balloon infusor

Publications (1)

Publication Number Publication Date
JPH01135359A true JPH01135359A (en) 1989-05-29

Family

ID=14843345

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63122737A Pending JPH01135359A (en) 1988-05-19 1988-05-19 Controller for feeding small amount of fluid

Country Status (1)

Country Link
JP (1) JPH01135359A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008055168A (en) * 2006-08-30 2008-03-13 Tecpharma Licensing Ag Dosing device for dosing fluid drug
WO2015037832A1 (en) * 2013-09-10 2015-03-19 Kim Young Mu Capillary device comprising internal filter, and injection fluid injection device comprising same
KR20160039353A (en) * 2014-10-01 2016-04-11 (주)가이버 Filter for Medical Infusion Line and Manufacturing Method Thereof
JP2017505690A (en) * 2014-02-14 2017-02-23 リチャード デニス グリーン System and method for removing gas
JP2020501669A (en) * 2016-12-16 2020-01-23 ソレント・セラピューティクス・インコーポレイテッド Fluid delivery device with gas extraction device and method of using same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008055168A (en) * 2006-08-30 2008-03-13 Tecpharma Licensing Ag Dosing device for dosing fluid drug
WO2015037832A1 (en) * 2013-09-10 2015-03-19 Kim Young Mu Capillary device comprising internal filter, and injection fluid injection device comprising same
JP2017505690A (en) * 2014-02-14 2017-02-23 リチャード デニス グリーン System and method for removing gas
KR20160039353A (en) * 2014-10-01 2016-04-11 (주)가이버 Filter for Medical Infusion Line and Manufacturing Method Thereof
JP2020501669A (en) * 2016-12-16 2020-01-23 ソレント・セラピューティクス・インコーポレイテッド Fluid delivery device with gas extraction device and method of using same

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