KR20210008989A - System for intraperitoneal hyperthermic pressureized gas circulation - Google Patents

Abstract

A system for intraperitoneal hyperthermic pressurized gas circulation according to the present invention comprises: a gas circulation device including a gas hose connected to the abdominal cavity of an individual and a pump connected to the gas hose for circulating gas, and circulating the gas discharged from the abdominal cavity back to the abdominal cavity; and a temperature control device for controlling the gas temperature of the gas circulation device so that the gas inside the abdominal cavity is at a constant temperature.

Description

Thermal pressurized gas circulation system in the abdominal cavity {SYSTEM FOR INTRAPERITONEAL HYPERTHERMIC PRESSUREIZED GAS CIRCULATION}

The present invention relates to a warm pressurized gas circulation system in the abdominal cavity, and more specifically, a gas circulation device and a temperature control device capable of circulating warm gas in the abdominal cavity, and a drug injection device that effectively injects the drug in the abdominal cavity together with gas It relates to a system comprising a. This system is particularly useful as a system for intraperitoneal thermal chemotherapy.

Recently, as a method for solving the low efficiency of drugs administered orally or intravascularly to metastasized cancer cells in the abdominal cavity, intraperitoneal chemotherapy (IPC) has been implemented.

In the case of pressurized intraperitoneal aerosol chemotherapy (PIPAC), an anticancer drug is injected directly into the cancer cells at about 10% of the dose of anticancer drug used in hyperthermic intraperitoneal chemotherapy (HIPEC). Although the therapeutic effect can be seen, there is a problem in that it is difficult to maintain the temperature in the abdominal cavity at a temperature of about 42° C. at which cancer cells die due to the temperature homeostasis of the human body (36° C.).

In addition, in the case of HIPEC, it is possible to maintain a temperature of about 42°C, but there is a problem that it is easy to cause side effects of chemotherapy due to a large amount of anticancer drugs and extensive surgery.

Korean Patent No. 1866455

In order to solve the above-described problem, the present invention includes a gas circulation device and a temperature control device capable of circulating gas at a constant temperature and pressure inside the abdominal cavity, and additionally, a drug that effectively injects the drug in the abdominal cavity with the gas It is an object of the present invention to provide a system that can further include an injection device.

In order to achieve this object, the system (device) for circulating warm pressurized gas in the abdominal cavity according to the embodiment of the present invention includes a gas hose connected to the abdominal cavity of the individual and a pump connected to the gas hose, and discharged from the abdominal cavity A gas circulation device that circulates the generated gas back into the abdominal cavity; And a temperature control device for controlling the gas temperature of the gas circulation device so that the gas inside the abdominal cavity becomes a constant temperature.

The gas circulation device includes: an intra-abdominal gas injection unit into which gas is injected into the abdominal cavity; And a circulation unit for discharging gas from the abdominal cavity to the outside and circulating the gas from the outside of the abdominal cavity and introducing the gas into the abdominal cavity again, wherein the temperature control device includes a gas temperature inside the abdominal cavity and a gas temperature of a gas circulation device outside the abdominal cavity A temperature sensor measuring the temperature of one or more of the gases; A heating device that provides heat to at least a portion of a gas hose of the gas circulation device; And a temperature control unit connected to the heating device and the temperature sensor, wherein the temperature control unit controls the temperature of the heating device so that the temperature of the gas inside the abdominal cavity becomes a constant temperature based on the measured value of the temperature sensor. .

In addition, the gas injection unit in the abdominal cavity may include a drug and a gas injection device for injecting the gas together when the gas is injected into the abdominal cavity of the individual.

With the system of the present invention, a gas for expanding the abdominal cavity of an individual, for example, carbon dioxide, is supplied and the gas inside the abdominal cavity is heated while circulating with a circulation pump of the circulation unit, thereby effectively maintaining the temperature inside the abdominal cavity. In addition, it is possible to evenly administer an atomized drug, for example, an anticancer agent, into the expanded abdominal cavity.

Such a system is used as a system for thermal chemotherapy in the abdominal cavity, and while maintaining the gas temperature in the abdominal cavity at a constant temperature, a small amount of the anticancer agent can be more effectively delivered to the cancer cells, thereby maximizing the anticancer treatment effect.

1 is a schematic diagram showing the configuration of a system device according to a first embodiment of the present invention.
2 is an enlarged partial cross-sectional view of part A in the system shown in FIG. 1.
3 is a schematic diagram schematically illustrating the system device shown in FIG. 1 together with a drug and a gas flow.
4 is a schematic diagram showing the configuration of a system device according to a second embodiment of the present invention.
5 is a schematic diagram schematically illustrating the system device shown in FIG. 4 together with a drug and a gas flow.
6 is a schematic diagram showing the configuration of a system device according to a third embodiment of the present invention.
7 is a schematic diagram schematically illustrating the system device shown in FIG. 6 together with a drug and a gas flow.
8 is a schematic diagram showing the configuration of a system device according to a fourth embodiment of the present invention.
9 is a schematic diagram schematically illustrating the system device shown in FIG. 8 together with a drug and a gas flow.
10 is a schematic diagram showing the configuration of a system device according to a fifth embodiment of the present invention.
11 is a schematic diagram schematically illustrating the system device shown in FIG. 10 together with a drug and a gas flow.

Hereinafter, embodiments of the present invention will be described in detail.

The system (device) according to the embodiments of the present invention is a system (device) for circulating hot pressurized gas in the abdominal cavity, and largely includes a gas circulation device and a temperature control device.

The gas circulation device includes a gas hose connected to the abdominal cavity of the subject and one or more pumps connected to the gas hose for circulating and pressurizing gas, and circulates gas discharged from the abdominal cavity back into the abdominal cavity.

In one embodiment, the gas circulating device includes an intraperitoneal gas input unit into which pressurized gas is injected into the abdominal cavity, and a circulation unit that discharges gas from the abdominal cavity to the outside, and circulates the gas from the outside of the abdominal cavity and puts it back into the abdominal cavity. Can include.

In one embodiment, the gas injection unit in the abdominal cavity may include one or more drugs and a gas injection device for injecting a drug together with gas when gas is injected into the abdominal cavity of the individual. In addition, it may further include one or more trocars (gas supply trocars) that are bushed into the abdominal cavity to supply gas separately from the drug and gas injection device.

In one embodiment, the drug and gas injection device is connected to a drug syringe for supplying a drug, a gas hose and supplied with a pressurized gas, receives a drug from the drug syringe, and is tubed into the abdominal cavity of the individual. It may include a drug and gas dispenser for administering a drug and a gas. At the end of the drug and gas dispenser, a nozzle for injecting the drug and gas into the abdominal cavity may be disposed.

In one embodiment, the drug and gas dispenser may be configured to include, for example, a head, a trunk portion extending from the head, and an abdominal cavity trocar portion below the trunk portion. The gas hose may be connected to at least one of the head and the body to supply gas. In addition, a temperature sensor may be mounted on one side of the body as described later.

In one embodiment, the nozzle is particularly preferably a two-fluid nozzle, as described below. When spraying from the nozzle, the pressure should be less than the pressure in the abdominal cavity, such as 6 to 14 mmHg or 6 to 15 mmHg.

In one embodiment, the gas circulation unit may include a circulation hose that is a gas hose of the circulation unit, and one or more circulation pumps connected to the circulation hose and increasing the pressure of the circulation gas.

The circulating gas of the gas circulation unit may be discharged from the gas discharge unit, rotated by a pump, and heated and/or pressurized through a temperature control device as described below, and then supplied back to the gas input unit in the abdominal cavity.

Here, the circulating gas of the gas circulation unit may be provided as a drug and a gas dispenser, a gas inlet trocar bushed into the abdominal cavity, or may be provided as each of the drug and gas dispenser and a gas inlet trocar.

In one embodiment, the gas circulation device may further include a gas supply unit for supplying gas. The gas supply unit may be configured to be connected to at least one of a gas input unit and a gas circulation unit in the abdominal cavity of the gas circulation device.

For example, in one embodiment, the gas supply unit may be connected so that the gas is supplied to the drug and the gas injection device of the gas injection unit in the abdominal cavity. The gas supply unit may include a gas injector for generating gas and a gas hose (first hose) through which gas flows from the gas injector and is connected to a drug and a gas injector. In addition, the gas supply unit may further include a pump that increases the pressure of the gas flowing through the gas hose.

In one embodiment, the gas hose of the gas supply unit may further include one or more branched gas hoses (second hoses). The hose branched in this way may be connected to the circulation unit.

In addition, in one embodiment, a gas supply unit for supplying gas to the circulation unit may be directly connected. The gas supply unit may include a gas injector generating gas and a gas hose (third hose) (not shown) through which gas flows from the gas injector and is connected to a circulation unit.

In one embodiment, the gas circulation unit may include one or more valves connecting two or more gas hoses.

For example, the circulation unit may include a circulation hose and a valve (first valve) for connecting a hose (second hose) branched from the gas hose (first hose) of the gas supply unit described above and discharging gas to the drug and gas dispenser. I can.

In addition, the circulation unit may include a valve (second valve) connecting the third hose and the circulation hose and discharging gas through the circulation pump.

In addition, the circulation unit may further include a valve (third valve) through which gas is introduced from the circulation pump and provides gas to the drug and gas dispenser. One or more gas hoses from the third valve may be connected to a drug and a gas dispenser. For example, two gas hoses from the third valve are connected to different positions of the drug and gas dispenser, or one gas hose is connected to the drug and gas dispenser from the third valve, and the other gas hose is It may be connected to the second trocar.

Meanwhile, the temperature control device controls the gas temperature of the gas circulation device so that the gas inside the abdominal cavity becomes a constant temperature. To this end, the temperature control device may measure the temperature of at least one of the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity, and then control the gas temperature in the abdominal cavity based on this.

Specifically, in one embodiment, the temperature control device, at least one temperature sensor for measuring the temperature of at least one of the gas temperature inside the abdominal cavity and the gas temperature of the gas circulation device outside the abdominal cavity, of the gas hose of the gas circulation device It may include a heating device, such as a heating coil, and a temperature controller (controller) connected to the heating device and the temperature sensor to provide heat to at least a portion.

The temperature controller (controller) may be to control the temperature of the heating device so that the gas temperature inside the abdominal cavity is maintained at a constant temperature, for example, 38°C to 42°C based on the measured value of the temperature sensor.

The temperature sensor may be provided in plural. That is, the system of the present invention may include at least a first temperature sensor for measuring the temperature of the gas injected into the abdominal cavity, and additionally, may include one or more sensors for measuring the temperature of the gas hose of the gas circulation device. For example, it may further include at least one of a second temperature sensor measuring the temperature of the circulating hose gas of the circulation unit, and a third temperature sensor measuring the temperature of the gas provided to the drug and gas dispenser in the circulation unit.

In one embodiment, the amount of gas supplied from each gas hose may be adjusted based on a measurement value of at least one of the second temperature sensor and the third temperature sensor. That is, since the temperature of the gas flowing through the gas hose such as the mild hose, the first hose, and the second hose may be different, each temperature is measured based on at least one temperature measurement value of the above-described second temperature and the third temperature sensor. By controlling the amount of gas flow in the gas hose, the temperature of the gas injected into the abdominal cavity can be controlled.

In one embodiment, the gas of the system may be carbon dioxide.

In one embodiment, the system for circulating warm pressurized gas in the abdominal cavity is a system for intraperitoneal thermal chemotherapy, and the drug may be an anticancer agent.

By using the above-described system, the temperature and pressure of the gas inside the abdominal cavity are effectively maintained in performing the intraperitoneal thermal chemotherapy, and the drug is evenly injected into the abdominal cavity, thereby maximizing the anticancer treatment effect.

Hereinafter, an embodiment of a system according to an embodiment of the present invention will be described in more detail with reference to the drawings. Hereinafter, the present invention will be described with reference to the embodiments shown in the drawings, but it will be understood that the technical idea of the present invention and its core configuration and operation are not limited accordingly.

A description of the configuration and operation that is redundant in each of the following embodiments will be omitted. For example, the nozzle of FIG. 2 can be used in common in all embodiments.

Embodiment 1

1 is a schematic diagram showing the configuration of a system 1 (hereinafter referred to as'system 1') including a gas circulation device and a temperature control device for maintaining the temperature in the abdominal cavity according to an embodiment of the present invention.

2 is an enlarged partial cross-sectional view of part A in the system shown in FIG. 1.

3 is a schematic diagram schematically illustrating the system device shown in FIG. 1 together with a drug and a gas flow.

1 to 3, the system (1) (device) injects pressurized gas for expanding the space inside the abdominal cavity (2) of the individual into the abdominal cavity, discharges it to the outside of the abdominal cavity, and then heats and/or It includes a gas circulation device that pressurizes and puts it back into the abdominal cavity, and a temperature control device that controls the temperature of the gas circulation device. Accordingly, the space inside the expanded abdominal cavity (2) maintains a constant temperature and pressure.

The gas circulation device is an intraperitoneal gas injection unit for injecting pressurized gas into the abdominal cavity, and includes a drug and gas injection device 20 for finely injecting gas and drugs into the abdominal cavity 2, and the drug and gas injection device It may include a gas supply unit 10 for supplying the pressurized gas to (20). In addition, the gas circulation device may include a circulation unit 30 for circulating gas.

First, the gas supply unit 10 includes a gas injector 11 for generating gas to expand the inside of the individual's abdominal cavity 2, a pump 12 for supplying the generated gas to the drug injector 20, and a gas injector. It may include a first hose 13 connected to the drug injection device 20 from (11) to transport gas.

The gas injector 11 supplies gas at a pressure of, for example, 12 to 14 bar, and the pump 12 supplies gas to the drug and gas injection device 20 at a pressure of, for example, about 3 bar. In this case, the gas may be carbon dioxide, for example.

The drug and gas injection device 20 is a device that atomizes a drug injected at high pressure with gas and evenly injects it into the abdominal cavity 2, a drug (for example, an anticancer drug) syringe 21, a drug and gas dispenser connected thereto (22) and a nozzle 23 at the end of the drug and gas dispenser.

The drug syringe 21 supplies the drug to be administered into the abdominal cavity 2 at high pressure on the drug and gas dispenser 22. At this time, the drug on the drug syringe 21 may be supplied to the drug and gas dispenser 22 at a pressure of about 1500 kPa or less.

The drug and gas dispenser 22 receives the pressurized gas from the gas supply unit 10 and the drug from the drug injector 21 and discharges the gas and the drug into the abdominal cavity 2 of the individual. At this time, in order to atomize and spray the drug, a nozzle 23 is installed at the end of the drug and gas dispenser 22.

Here, preferably, the nozzle 23 may be a two-fluid nozzle 23 ′, as shown in FIG. 2. 2 is a cross-sectional view of the two-fluid nozzle 23', through which the gas and the drug are injected together. Specifically, the drug supplied through the drug line 231 and the gas supplied through the gas line 232 are mixed in the mixing chamber 233 and finely injected through the outlet 234.

As described above, since the system 1 according to a preferred embodiment of the present invention atomizes the drug on the principle of a two-fluid nozzle, the degree of atomization is excellent compared to the hydraulic nozzle used in the existing PIPAC, and the level of atomization is excellent. It is easy to adjust the spraying direction. In the case of such micronized anticancer drugs, they spread evenly into the expanded abdominal cavity (2) and act effectively on the peritoneum to which cancer cells have metastasized.

In addition, a first temperature sensor 42 for measuring the temperature of the gas injected into the abdominal cavity 2 may be disposed at an end of the nozzle of the drug and gas injection device 20. As described later, by measuring the temperature of the gas with the first temperature sensor 42, the temperature of the gas discharged into the abdominal cavity of the individual is 38 to 42 °C, preferably 41 to 42 °C, more preferably 42 °C. Can be maintained. Accordingly, it is possible to maximize the anticancer treatment effect by increasing the penetration of anticancer drugs into the patient's peritoneal carcinomatosis.

On the other hand, the gas injected into the inside of the individual's abdominal cavity 2 pressurizes the inner wall of the individual's abdominal cavity to expand the abdominal cavity, and discharges and circulates.

To this end, the circulation unit 30 discharges gas from the abdominal cavity to the outside to recover the gas into the system 1, circulates outside the abdominal cavity, and puts it back into the abdominal cavity.

Specifically, the circulation unit 30 is a trocar (gas discharge trocar; hereinafter, the first trocar) 31, a circulation pump 32, a circulation hose 33, and a circulation valve ( 34) may be included. That is, the first trocar 31 is inserted into the abdominal cavity 2 as a gas recovery device in the abdominal cavity to recover gas in the abdominal cavity 2. The recovered gas is supplied to the circulation valve 34 through the circulation hose 33. At this time, the circulation pump 32 pressurizes the gas to enable circulation of the recovered gas.

Meanwhile, a loss may occur in the process of recovering the gas circulated in the abdominal cavity 2 on the system 1. Gas in an amount corresponding to the lost gas may be supplied to the circulation valve 34 through the second hose 35 branched between the gas injector 11 and the pump 12.

The circulation valve 34 can supply or block the gas recovered from the inside of the abdominal cavity 2 and/or the gas supplied by the second hose 35 again to the drug and gas dispenser 22 through opening and closing of the valve. have.

The temperature control device is a temperature sensor that measures the temperature of the gas to control the temperature of the gas to a constant temperature, a heating coil (heating device) that heats the gas hose, and controls the heating coil based on the measured value of the temperature sensor. A temperature control unit (controller) 40 may be included.

The temperature control device includes a heating coil 41 wound around each of the first hose 13, the second hose 35 and the circulation hose 33, the first temperature sensor 42, the second temperature sensor 43, and 3 may include a temperature sensor 44. For reference, for convenience, the heating coils 41 wound around each of the first hose 13, the second hose 35 and the circulation hose 33 are referred to as a first heating coil, a second heating coil, and a third heating coil, respectively. I can.

The temperature controller (controller) 40 adjusts the voltage applied to the heating coil 41 and the degree of heat generation of the heating coil 41 according to the temperature measured by each of the temperature sensors 42, 43, 44 By doing so, the gas temperature can be brought to a constant temperature. Accordingly, the temperature of the gas discharged into the abdominal cavity 2 of the individual can be maintained at a constant temperature.

Hereinafter, with reference to FIG. 3 in particular, it will be described with respect to the drug injection and temperature maintenance in the abdominal cavity.

When drugs and gases are discharged into the abdominal cavity 2 of the individual, the circulation valve 34 may be closed. Accordingly, the gas supplied to the drug dispenser 22 is a gas supplied from the gas supply unit 10, and the supply of gas through the circulation hose 33 and the circulation valve 34 connected to the second hose 35 is Closed. The temperature of the drug and gas discharged into the abdominal cavity 2 of the individual is measured by the first temperature sensor 42, and the temperature controller 40 is based on the measured value of the first temperature sensor 42, The heating device is controlled so that the temperature of the interior 2 is maintained at 38 to 42°C or preferably at 41 to 42°C, more preferably at 42°C as described above.

Specifically, the temperature control unit 40 regulates the temperature of the heating coil 41 wound around the first hose 13 between the gas supply unit 10 and the drug dispenser 22, and supplies it through the gas supply unit 10. You can adjust the temperature of the gas to be used.

Next, after all of the drugs on the drug syringe 21 are administered into the individual abdominal cavity 2, the gas in the abdominal cavity is circulated. At this time, the gas recovered on the circulation unit 30 is in a state in which the temperature is lowered by heat transfer in the abdominal cavity 2. Accordingly, the temperature of the recovered gas is increased by the hot wire coil 41 wound on the circulation hose 33. The temperature of the gas in the circulation hose 33 is measured by the second temperature sensor 43 and may be maintained at a predetermined set value.

On the other hand, the gas lost in the abdominal cavity 2 of the individual may be replenished through the second hose 35, and the temperature of the gas in the second hose 35 may be lower than the temperature of the gas in the circulation hose 33. have. Therefore, the temperature of the gas in the circulation hose 33 can be maintained above 42°C, and the set value of the temperature of the gas in the circulation hose 33 is adjusted according to the amount of gas supplied through the second hose 35 Can be.

The circulation valve 34 is recovered in the abdominal cavity 2 and mixed with the gas supplied by the circulation hose 33 and/or the gas supplied by the second hose 35. A third temperature sensor 44 is disposed between the circulation valve 34 and the drug dispenser 22. Accordingly, the third temperature sensor 44 measures a temperature when the gas supplied by the circulation hose 33 and/or the gas supplied by the second hose 35 are mixed. The temperature controller 40 may adjust the temperature of the coil wound around the circulation hose 33 and/or the coil wound around the second hose 35 based on the temperature of the gas measured by the third temperature sensor 44.

In addition, the first temperature sensor 42 measures the temperature of the gas discharged into the abdominal cavity 2 of the individual. The temperature control unit 40 adjusts the temperature of the gas measured by the third temperature sensor 44 based on the measured value of the first temperature sensor 42, thereby adjusting the temperature of the inside of the abdominal cavity 2 as described above. Likewise, it can be adjusted to maintain at 38 to 42 °C or preferably 41 to 42 °C, more preferably 42 °C.

As described above, the system 1 of the present invention includes a plurality of temperature sensors 42, 43, and 44, the heating coil 41, and the temperature control unit 40 for controlling the temperature, so that the temperature inside the abdominal cavity 2 is It can be kept constant at a set predetermined value.

Embodiment 2

4 is a schematic diagram showing the configuration of a system device according to a second embodiment of the present invention. 5 is a schematic diagram schematically illustrating the system device shown in FIG. 4 together with a drug and a gas flow.

4 and 5, the system 1 (device) of the present embodiment is similar in configuration to that of the first embodiment, except that the gas supply unit is directly connected to the circulation unit.

That is, the circulation unit 30 further includes a gas supply unit 10 for supplying gas to the circulation unit, wherein the gas supply unit includes a gas injector 11 generating gas and a gas from the gas injector 11 It flows and includes a gas hose (third hose) connected to the circulation unit 30. The gas injector 11 may supply gas at a pressure of, for example, 12 to 14 bar, as in the first embodiment, and this gas pressure may be adjusted while passing through the circulation pump 32.

In addition, the circulation unit 30 may further include a three-way valve (second valve) 34 through which the gas of the third hose and the gas of the circulation hose are introduced, and the gas is discharged to the circulation pump 32. . In addition, it may further include a three-way valve (third valve) 34 through which gas is introduced from the circulation pump 32 and provides gas to the drug and gas dispenser 22.

One or more gas hoses, such as two gas hoses, from the third valve may be connected to different positions of the drug and gas dispenser 22, such as a head part and a body part, respectively.

It is the same as in the first embodiment that a temperature sensor (third temperature sensor) 44 for measuring the gas temperature of the gas hose connected to the tube can be provided, and the rest of the configuration and operation are also the first embodiment. Same as

Embodiment 3

6 is a schematic diagram showing the configuration of a system device according to a third embodiment of the present invention. 7 is a schematic diagram schematically illustrating the system device shown in FIG. 6 together with a drug and a gas flow.

6 and 7, the system 1 (device) of this embodiment is similar in configuration to that of the second embodiment, except that from the three-way valve (third valve) 34 of the circulation unit 30 One gas hose is connected to the drug and gas dispenser 22, and the other gas hose is connected to a gas inlet trocar (hereinafter, referred to as the second trocar) 37, which is a trocar for the injection of gas to be piped into the abdominal cavity. There is a difference.

Accordingly, in the drug and gas dispenser 22, the drug and the gas are injected into the abdominal cavity together, and the gas may be injected into the abdominal cavity through a separate second trocar. Other configurations and operations are the same as in the second embodiment.

Embodiment 4

8 is a schematic diagram showing the configuration of a system device according to a fourth embodiment of the present invention. 9 is a schematic diagram schematically illustrating the system device shown in FIG. 8 together with a drug and a gas flow.

8 and 9, the system 1 (device) of the present embodiment is similar in configuration to that of the first embodiment, except that the gas injector 11 of the gas supply unit is used without a separate branch hose or pump. It is connected to the head of the gas dispenser 22.

In addition, in the circulation unit 30, the circulation hose 33 is connected toward the body of the drug and gas dispenser 22, and a second temperature sensor is mounted thereto to measure the temperature. Other configurations and operations are the same as in the first embodiment.

Embodiment 5

10 is a schematic diagram showing the configuration of a system device according to a fifth embodiment of the present invention. 11 is a schematic diagram schematically illustrating the system device shown in FIG. 10 together with a drug and a gas flow.

10 and 11, the system 1 (device) of this embodiment is similar in configuration to that of the fourth embodiment, except that in the circulation unit 30, the circulation hose 33 is a drug and gas dispenser ( 22), but is connected to the second trocar 37, which is a separate bushing for gas input.

The second temperature sensor 43 for measuring the gas temperature is provided in the gas hose of the circulation unit 30 as in the first embodiment. Other configurations and operations are the same as in the first embodiment.

Although the embodiments of the present invention have been described in more detail with reference to the accompanying drawings above, the present invention is not necessarily limited to these embodiments, and various modifications may be made without departing from the spirit of the present invention. have. Accordingly, the embodiments disclosed in the present invention are not intended to limit the technical idea of the present invention, but to explain the technical idea, and the scope of the technical idea of the present invention is not limited by these embodiments. Therefore, it should be understood that the embodiments described above are illustrative and non-limiting in all respects. The scope of protection of the present invention should be interpreted by the following claims, and all technical ideas within the scope equivalent thereto should be interpreted as being included in the scope of the present invention.

1: system 2: inside the abdominal cavity
10: gas supply unit 11: gas injector
12: pump 13: first hose
20: drug injection device 21: drug syringe
22: drug dispenser 23 (23'): nozzle (air-fluid nozzle)
30: circulation unit 31: first trocar
32: circulation pump 33: circulation hose
34: circulation valve 35: second hose
37: second trocar 40: temperature control unit
41: heating coil 42: first temperature sensor
43: second temperature sensor 44: third temperature sensor

Claims (18)

As a system for circulating heated and pressurized gas in the abdominal cavity,
A gas hose connected to the abdominal cavity of the individual and a gas circulation device connected to the gas hose and including a pump for circulating gas, and circulating the gas discharged from the abdominal cavity back to the abdominal cavity; And
And a temperature control device for controlling the gas temperature of the gas circulation device so that the gas inside the abdominal cavity becomes a constant temperature.
The method of claim 1,
The gas circulation device includes: an intra-abdominal gas injection unit into which gas is injected into the abdominal cavity; And a circulation unit that discharges gas from the abdominal cavity to the outside and circulates the gas from the outside of the abdominal cavity and puts the gas back into the abdominal cavity; including,
The temperature control device may include a temperature sensor that measures at least one of a gas temperature inside the abdominal cavity and a gas temperature of a gas circulation device outside the abdominal cavity; A heating device that provides heat to at least a portion of a gas hose of the gas circulation device; And a temperature control unit connected to the heating device and the temperature sensor,
And the temperature controller controls the temperature of the heating device so that the temperature of the gas inside the abdominal cavity becomes a constant temperature based on the measured value of the temperature sensor.
The method of claim 2,
And a gas injection device for injecting a drug together with gas when the gas is injected into the abdominal cavity of the individual.
The method of claim 3,
The drug and gas injection device, a drug syringe for supplying a drug;
A drug and gas dispenser connected to a gas hose to receive pressurized gas, to receive a drug from the drug syringe, and to administer drugs and gas into the abdominal cavity of the individual by being tubed into the abdominal cavity; And
And a nozzle disposed at the distal end of the drug and gas dispenser and spraying the drug and gas into the abdominal cavity.
The method of claim 4,
The circulation unit includes a first trocar that is piped into the abdominal cavity and discharges gas, a circulation hose that is a gas hose connected to the first trocar, and a circulation pump that is connected to the circulation hose and increases the pressure of the circulation gas, and
The circulating gas of the circulation unit is provided to the drug and gas dispenser, or as a second trocar administered to the abdominal cavity, or to the drug and gas dispenser and the second trocar.
The method of claim 5,
The gas injection unit in the abdominal cavity further includes a gas supply unit for supplying gas to the drug and the gas injection device,
The gas supply unit may include a gas injector for generating gas; And
And a first hose through which the gas from the gas injector flows and is connected to a drug and a gas injection device.
The method of claim 6,
The gas supply unit further comprises a pump for increasing the pressure of the gas flowing through the first hose.
The method of claim 6,
The gas supply unit further includes a second hose branched from the first hose,
The circulation unit further comprises a first valve through which gas from the circulation hose and the second hose is introduced and the gas is discharged to the drug and gas dispenser.
The method of claim 5,
The circulation unit further includes a gas supply unit for supplying gas to the circulation unit,
The gas supply unit may include a gas injector for generating gas; And
And a third hose through which the gas from the gas injector flows and is connected to a circulation unit.
The method of claim 9,
The system further comprises a second valve through which the gas of the third hose and the gas of the circulation hose are introduced, and the gas is discharged through the circulation pump.
The method of claim 9,
The circulation unit further includes a third valve through which gas is introduced from a circulation pump and provides gas to a drug and a gas dispenser,
At least one gas hose from the third valve to a drug and gas dispenser.
The method of claim 11,
Two gas hoses are connected from the third valve to different positions of the drug and gas dispenser, or one gas hose is connected to the drug and gas dispenser from the third valve, and the other gas hose is connected to the second A system characterized in that it is connected by a trocar.
The method of claim 5,
The heating device is a heating coil surrounding at least a portion of the gas hose,
The temperature control device includes a first temperature sensor that measures the temperature of the gas injected into the abdominal cavity,
The system according to claim 1, wherein the temperature of the heating coil is controlled so that the temperature of the gas inside the abdominal cavity is maintained at 38°C to 42°C based on the measured value of the first temperature sensor.
The method of claim 13,
The temperature control device includes: a second temperature sensor measuring a temperature of a gas in the circulation unit; And a third temperature sensor measuring the temperature of the gas provided to the drug and gas dispenser in the circulation unit. The system further comprising at least one of.
The method of claim 10,
The system according to claim 1, wherein the gas supply amount from each gas hose is adjusted based on a measurement value of at least one of the second temperature sensor and the third temperature sensor.
The method of claim 4,
The system, characterized in that the nozzle is a two-fluid nozzle.
The method according to any one of claims 1 to 16,
The system, characterized in that the gas is carbon dioxide.
The method according to any one of claims 1 to 16,
The system is a system for intraperitoneal thermal chemotherapy, wherein the drug is an anticancer agent.

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