WO2022263631A1 - Prothese biologique destinee a la reconstruction de la plaque areolo-mamelonnaire - Google Patents
Prothese biologique destinee a la reconstruction de la plaque areolo-mamelonnaire Download PDFInfo
- Publication number
- WO2022263631A1 WO2022263631A1 PCT/EP2022/066562 EP2022066562W WO2022263631A1 WO 2022263631 A1 WO2022263631 A1 WO 2022263631A1 EP 2022066562 W EP2022066562 W EP 2022066562W WO 2022263631 A1 WO2022263631 A1 WO 2022263631A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- prosthesis
- biological
- nipple
- section
- biological prosthesis
- Prior art date
Links
- 241000283690 Bos taurus Species 0.000 claims abstract description 7
- 241000283707 Capra Species 0.000 claims abstract description 6
- 241000282887 Suidae Species 0.000 claims abstract description 6
- 210000000481 breast Anatomy 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 230000002779 inactivation Effects 0.000 claims description 5
- 230000003612 virological effect Effects 0.000 claims description 5
- 241000282414 Homo sapiens Species 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 description 22
- 210000004207 dermis Anatomy 0.000 description 17
- 238000000034 method Methods 0.000 description 16
- 239000007943 implant Substances 0.000 description 10
- 210000002445 nipple Anatomy 0.000 description 8
- 238000001356 surgical procedure Methods 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 7
- 210000004883 areola Anatomy 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 4
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 4
- 210000002744 extracellular matrix Anatomy 0.000 description 4
- 238000005070 sampling Methods 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 3
- 230000008030 elimination Effects 0.000 description 3
- 238000003379 elimination reaction Methods 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 101710189920 Peptidyl-alpha-hydroxyglycine alpha-amidating lyase Proteins 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229930182830 galactose Natural products 0.000 description 2
- 239000005445 natural material Substances 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 101000959111 Homo sapiens Peptidyl-alpha-hydroxyglycine alpha-amidating lyase Proteins 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000009933 burial Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 102000055412 human PAM Human genes 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 208000030776 invasive breast carcinoma Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/50—Prostheses not implantable in the body
- A61F2/52—Mammary prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/50—Prostheses not implantable in the body
- A61F2/52—Mammary prostheses
- A61F2002/526—Nipples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0008—Rounded shapes, e.g. with rounded corners elliptical or oval
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/04—Materials or treatment for tissue regeneration for mammary reconstruction
Definitions
- the invention relates to a new biological prosthesis made from an animal nipple-areolar plaque, useful in particular in breast reconstruction after mastectomy.
- a mastectomy is a surgical procedure that involves removing the breast in which the tumor is located in its entirety, including the areola and the nipple. It is known that approximately 1 in 8 women will develop invasive breast cancer during her lifetime. A third of these cancers require a mastectomy. Nipple-areolar plaque (PAM) reconstruction is the final step in the post-mastectomy reconstruction journey. Different methods exist to recreate the lost anatomical portion with a risk mainly associated with a loss of projection or flattening of the nipple. It is therefore necessary to associate a prosthetic material with the surgery.
- PAM Nipple-areolar plaque
- the surgical techniques used involve autologous skin grafts for the areola and local flaps for the nipple. It can also be proposed the creation of a tattoo for the areola.
- the removal of an autologous graft necessarily implies the creation of a loss of substance on another anatomical portion, therefore potential complications with a non-guaranteed aesthetic result.
- the creation of a tattoo does not restore the lost anatomical portion.
- the reconstruction of the MAP must make it possible to better integrate the reconstructed breast into the patient's personal psychological scheme.
- a synthetic silicone prosthetic material has recently been introduced (under the name Fixnip). Complications related to the use of silicone implants in breast implants are widely described in the literature. In addition, recent restrictions (prohibition of macro-textured implants, ASIA syndrome, etc.) plead for the use of biological materials in this type of reconstruction, as well as the use of a silicone prosthetic material in surgery of the PAM does not appear to be consistent. In addition, placing subcutaneous implants presents a risk of ulceration with exposure of the implant.
- the objective of the invention is to meet this need by proposing a biological prosthesis overcoming the problems of the prior art.
- the present invention proposes using an areola-nipple plaque taken from an animal.
- Animal skin in particular porcine skin, has already been used for several years for the manufacture of biological prostheses in wall surgery and breast reconstruction.
- animal dermis for the manufacture of prostheses in the case of the reconstruction of the PAM would require many manipulations and assemblies of parts of dermis to obtain the desired shape, which seems difficult to achieve both from a technical point of view and from an economic point of view.
- the present invention relates to a biological prosthesis made from a very specific part of the animal, adapted to the shape of a human PAM, which avoids these problems.
- the invention relates to a biological prosthesis constituted in whole or in part by an areola-nipple plate belonging to the family of pigs, cattle or goats, said areola-nipple plate having been treated to allow use in the being human, preferably at least by acellularization and/or deantigenization and/or viral inactivation.
- the prosthesis according to the invention therefore comprises a flat or substantially flat section, and a protruding section preferably disposed substantially at the center of said flat section.
- such a prosthesis has a shape quite suitable for the reconstruction of the PAM in a woman since it is obtained from the anatomical section (PAM) in the animal, and this without having to manipulate and assemble different parts of the dermis. It is simple to manufacture, and being a biological prosthesis, it replaces the autologous grafts usually used in this type of surgical intervention.
- FIG. 1 represents a diagram of the prosthesis according to the invention.
- FIG. 2 represents a diagram of the removal of the part of the animal to manufacture the prosthesis according to the invention.
- FIG. 3 represents a photograph of a prosthesis according to the invention.
- acellularization within the meaning of the invention is meant the elimination of cellular elements. So that the prosthesis can be implanted in a recipient, the tissues taken from the donor animal are decellularized so as to reduce their immunogenicity. This process involves the elimination of cells from the donor animal while preserving the biological and mechanical qualities of the extracellular matrix.
- deantigenization within the meaning of the invention is meant the elimination of proteins present in the tissue of the donor animal which could not be recognized by the recipient of the prosthesis. thus causing rejection of the implant.
- the donor animal may express enzymes or proteins in the tissue which are not expressed by the recipient. It is therefore important to eliminate these elements, such as in particular the galactose epitope alpha-1,3 galactose (alpha-gai) present in the porcine species, in order to reduce the immune response after implantation in humans.
- protuberance or “protruding section” within the meaning of the invention is meant a bump-shaped projection. This protuberance corresponds to the general shape of a nipple.
- prosthesis within the meaning of the invention is meant a medical device used in surgery.
- biological prosthesis or “bioprosthesis” within the meaning of the invention, a prosthesis obtained from an animal tissue.
- the invention therefore relates to a biological prosthesis 10 as represented in FIG. 1.
- the biological prosthesis according to the invention is a biological prosthesis 10 constituted in whole or in part by an areola-nipple plate 14 of an animal belonging to the family of pigs, cattle or goats, said areola-nipple plate having been treated so as to allow use in humans, preferably by acellularization and/or deantigenization and/or viral inactivation.
- the biological prosthesis according to the invention is therefore a biological tissue corresponding to an areola-nipple plaque 14 taken from an animal belonging to the family of pigs, cattle or goats, then treated, preferably at least by acellularization and/or deantigenization and/or viral inactivation.
- the biological prosthesis 10 comprises a flat or substantially flat section 18 (it is not necessarily perfectly flat due to the natural material used), and a protruding section 16 preferably disposed at the center or substantially at the center of said section 18.
- Section 18 corresponds to the areola and section 16 to the nipple.
- Section 18 is preferably circular or oval or substantially circular or substantially oval in shape.
- the thickness e of the section 18 is between 0.5 and 4 mm, more preferably between 0.5 and 2 mm.
- the thickness e for the same prosthesis can vary and a prosthesis can have different thicknesses or else substantially the same thickness, said thicknesses being preferably between 0.5 and 4 mm, preferably between 0.5 and 2 mm.
- the thickness 12 varies according to the desired mechanical strength, because the greater the thickness, the less flexible the material. To obtain such a thickness, it may be necessary to split the dermis in the thickness, to the desired size, using sharp means such as a knife for example.
- the protruding section 16 has a height h preferably between 0.5 and 20 mm, preferably between 7 and 10 mm.
- the mean diameter D of section 18 is preferably between 10 and 60 mm, even more preferably between 15 and 50 mm. Section 18 may have a larger diameter at the time of sampling and be recut according to the desired final average diameter D.
- the mean diameter d of section 16 is preferably between 5 and 20mm, preferably between 5 and 15mm.
- the removal of the biological prosthesis according to the invention before treatment is carried out on a part of an animal belonging to the family of pigs, cattle or goats (preferably a check mark) corresponding to the ventral part of the animal comprising several nipple-areolar sections of the animal.
- the sample is preferably taken from the ventral part (abdomen and/or thorax) of one or more zones 14, each zone 14 corresponding to an areola-nipple plaque.
- Animal dermis, and in particular porcine dermis is particularly suitable because its mechanical strength allows it to be used in surgery. Furthermore, the composition of the extracellular matrix, particularly collagen, of the porcine dermis is similar to that of human beings.
- the dermis is treated, in particular by acellularization and deantigenization.
- This treatment makes it possible to eliminate in particular the cellular elements and the alpha-gai epitope which can cause an increased immune reaction and acute rejection of the implant of animal origin.
- the mechanical strength of the biological prosthesis 10 according to the invention preferably responds to the following parameters (measured according to the methods described in the US Pharmacopeia Scaffold Bovine Dermis):
- the biological prosthesis 10 according to the invention can be dried. Preferably, it is freeze-dried because this drying technique is particularly suitable for preservation of collagen which is a very temperature sensitive protein. For its use, the prosthesis must be rehydrated by any method known for this purpose.
- the biological prosthesis according to the invention can be manufactured by any suitable method.
- the sample is taken from a dead animal, just after it has been slaughtered, directly in the slaughterhouse.
- the separation of the dermis from the rest of the integument is carried out using any sharp means, such as a knife for example, preferably directly after sampling in the slaughterhouse.
- the dermis is split using any sharp means, such as a knife for example or a splitter. This step must be carried out with precision so as to preferably obtain a substantially uniform thickness over the whole of the prosthesis.
- the method may include a freeze-drying step.
- the biological prosthesis according to the invention is preferably packaged in sterile packaging.
- the biological prosthesis retains the qualities of the extracellular matrix from which it is extracted and promotes tissue integration, thus avoiding the erosion of adjacent tissues.
- the prosthesis according to the invention must not be removed, unlike synthetic prostheses. Indeed its biological nature will at worst lead to a simple resorption
- the prosthesis is used according to any suitable technique. According to one embodiment, it is used by a method comprising the implementation of the following steps:
- the invention is now illustrated by a specific example of sampling and obtaining and examples of biological prostheses according to the invention, obtained according to this method.
- Example of a process for manufacturing a prosthesis according to the invention All the PAMs of a notch are taken after slaughter and before any other processing process.
- the dermis of the MAP is then separated with a knife from the other subcutaneous anatomical elements of the MAP so as to preserve the cutaneous sheath as much as possible.
- the dermis can be split using a knife or other sharp tools over the entire lower surface and in a uniform manner without cutting into the nipple.
- the prosthesis thus obtained is then treated by various chemical treatments in order to eliminate the cellular elements and other molecules specific to the organism of the donor.
- the prosthesis is then freeze-dried for optimal conservation but can also be preserved by impregnation with an appropriate chemical solution.
- a final cut is made to obtain the desired final dimensions.
- the implants are then sterilized by conventional techniques (ETO, radiation, supercritical C02, peracetic acid).
- the PAM was taken from a sow aged 5 to 9 months and then treated according to the method described above.
- Example 2
- the PAM was taken from a sow aged 20 months and then treated according to the method described above.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR112023026579A BR112023026579A2 (pt) | 2021-06-17 | 2022-06-17 | Prótese biológica destinada à reconstrução do conjunto mamilo-aréola |
EP22735379.4A EP4355272A1 (fr) | 2021-06-17 | 2022-06-17 | Prothese biologique destinee a la reconstruction de la plaque areolo-mamelonnaire |
CA3220761A CA3220761A1 (fr) | 2021-06-17 | 2022-06-17 | Prothese biologique destinee a la reconstruction de la plaque areolo-mamelonnaire |
KR1020247000627A KR20240038958A (ko) | 2021-06-17 | 2022-06-17 | 유두-유륜 복합체의 재건을 위한 생물학적 보형물 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FRFR2106446 | 2021-06-17 | ||
FR2106446A FR3124076A1 (fr) | 2021-06-17 | 2021-06-17 | Prothese biologique destinee a la reconstruction de la plaque areolo-mamelonnaire |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2022263631A1 true WO2022263631A1 (fr) | 2022-12-22 |
Family
ID=77226903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2022/066562 WO2022263631A1 (fr) | 2021-06-17 | 2022-06-17 | Prothese biologique destinee a la reconstruction de la plaque areolo-mamelonnaire |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP4355272A1 (fr) |
KR (1) | KR20240038958A (fr) |
BR (1) | BR112023026579A2 (fr) |
CA (1) | CA3220761A1 (fr) |
FR (1) | FR3124076A1 (fr) |
WO (1) | WO2022263631A1 (fr) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170224869A1 (en) * | 2016-02-08 | 2017-08-10 | Lifecell Corporation | Biologic breast implant |
US20190209281A1 (en) * | 2016-06-17 | 2019-07-11 | Meccellis Biotech | Biological prosthesis intended for the treatment of parastomal hernias |
US20210052774A1 (en) * | 2019-08-21 | 2021-02-25 | Lifecell Corporation | Fixed-shape tissue matrix and related methods |
-
2021
- 2021-06-17 FR FR2106446A patent/FR3124076A1/fr active Pending
-
2022
- 2022-06-17 WO PCT/EP2022/066562 patent/WO2022263631A1/fr active Application Filing
- 2022-06-17 CA CA3220761A patent/CA3220761A1/fr active Pending
- 2022-06-17 EP EP22735379.4A patent/EP4355272A1/fr active Pending
- 2022-06-17 BR BR112023026579A patent/BR112023026579A2/pt unknown
- 2022-06-17 KR KR1020247000627A patent/KR20240038958A/ko unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170224869A1 (en) * | 2016-02-08 | 2017-08-10 | Lifecell Corporation | Biologic breast implant |
US20190209281A1 (en) * | 2016-06-17 | 2019-07-11 | Meccellis Biotech | Biological prosthesis intended for the treatment of parastomal hernias |
US20210052774A1 (en) * | 2019-08-21 | 2021-02-25 | Lifecell Corporation | Fixed-shape tissue matrix and related methods |
Non-Patent Citations (2)
Title |
---|
BADYLAK ET AL.: "Extracellular Matrix as a Biological Scaffold Material: Structure and Function", ACTA BIOMATERIALIA, 2008 |
XU ET AL., TISSUE ENGINEERING, vol. 15, 2009, pages 1 - 13 |
Also Published As
Publication number | Publication date |
---|---|
BR112023026579A2 (pt) | 2024-03-05 |
KR20240038958A (ko) | 2024-03-26 |
EP4355272A1 (fr) | 2024-04-24 |
CA3220761A1 (fr) | 2022-12-22 |
FR3124076A1 (fr) | 2022-12-23 |
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