WO2022262357A1

WO2022262357A1 - Assisted reproduction carrier rod assembly

Info

Publication number: WO2022262357A1
Application number: PCT/CN2022/083995
Authority: WO
Inventors: 李维杰; 宋立勇; 王义姚; 宗果
Original assignee: 上海明悦医疗科技有限公司
Priority date: 2021-06-18
Filing date: 2022-03-30
Publication date: 2022-12-22
Also published as: CN115486437A; CN115486437B

Abstract

An assisted reproduction carrier rod assembly, the assisted reproduction carrier rod assembly comprising a carrier rod body (100) and an RFID chip (200). The carrier rod body (100) comprises a carrier rod handle (101) and a sample carrier (102), the sample carrier (102) containing graphene, the sample carrier (102) being connected to the carrier rod handle (101), and the sample carrier (102) having provided thereon a sample storage groove for storing an embryo sample (20). The carrier rod handle (101) has the RFID chip (200) connected thereon, the RFID chip (200) being used to record information about the embryo sample (20), and the RFID chip (200) being able to identify and communicate with an RFID reader-writer.

Description

Assisted reproductive rod assembly

Cross References to Related Applications

This application claims the priority of the Chinese patent application with application number 202110677378.5 submitted to the China Patent Office on June 18, 2021, the entire content of which is incorporated by reference in this application.

technical field

This application relates to the field of medical equipment and assisted reproductive technology.

Background technique

Embryo freezing technology is one of the important technical means of human assisted reproductive technology (ART). Embryo freezing can save embryos or oocytes for patients, improve the cumulative pregnancy rate of patients and reduce costs. Vitrification technology in embryo freezing technology is widely used in assisted reproductive technology because of its high recovery rate, no need for large-scale equipment, quickness and simplicity. However, in addition to the prospective safety issues that have attracted much attention in clinical applications, the potential toxicity of high-concentration vitrification liquid to embryo development, the details of operation engineering, and frozen straws will all have an impact on embryo development.

Vitrification load rods commonly used in the market are divided into closed load rods and open load rods. The closed carrier can not conduct heat quickly, the cooling speed of the embryo is slow, and the rewarming speed is also slow, the survival rate of the preserved embryo is low, and the loss of the embryo is large. When the open carrier is used, the embryo is directly placed on the front end sheet of the open carrier, and then the sheet is directly placed in liquid nitrogen and covered with an outer sleeve. When the embryo is cryopreserved, the embryo is in direct contact with the liquid nitrogen, and the glass However, the contact surface between the slice and the embryo cannot be directly immersed in liquid nitrogen, and the cooling rate is still affected by the material of the support rod slice, so the recovery rate of the embryo is low, and the live birth rate of the embryo is low. In addition, when the closed carrier and the open carrier are used, the embryo information is marked with a label, and the label is easy to fall off, so the embryo information is easily lost, and the embryo information is not guaranteed.

Contents of the invention

According to various embodiments of the present application, an assisted reproductive straw assembly is provided.

An assisted reproductive rod assembly includes a rod main body and a first RFID chip. The rod main body includes a rod handle and a sample carrier connected to the rod handle. The sample carrier contains graphene, and the sample carrier is provided with a sample storage tank for storing embryo samples. The first RFID chip is connected to the carrying rod handle, and the first RFID chip is used to record embryo sample information, and the first RFID chip can communicate with an RFID reader.

In one of the embodiments, the main body of the carrying rod further includes a protective sleeve, at least one end of which is open, and the protective sleeve can be sleeved and fitted with the sample carrier.

In one of the embodiments, both ends of the protective cover are open.

In one of the embodiments, the sample carrier is in the shape of a strip, and the sample carrier extends along the axial direction of the rod handle.

In one of the embodiments, the length of the protective sheath is greater than the length of the sample carrier.

In one of the embodiments, the protective cover is made of transparent material.

In one of the embodiments, both the sample carrier and the rod-loading handle have a columnar structure, the radial dimension of the sample-carrying member is smaller than the radial dimension of the rod-loading handle, and the protective sleeve is sleeved on the rod. The sample carrier is then abutted against the stem handle.

In one of the embodiments, the assisted reproduction stem assembly further includes a stem box part. The rod carrier box part includes a first box body and a second box body capable of matingly connecting with the first box body. The first box body has a first accommodating groove, and the second box body has a second accommodating groove; when the first box body and the second box body are mated and connected, the first accommodating The groove communicates with the second accommodating groove to form an accommodating cavity for accommodating the main body of the carrier rod.

In one of the embodiments, the first box body and/or the second box body are provided with identification parts.

In one embodiment, a second RFID chip is connected to the first box and/or the second box.

In one of the embodiments, the first box body is provided with a first communicating hole communicating with the first accommodating groove;

In one of the embodiments, the second box body is provided with a second communicating hole communicating with the second accommodating groove.

In one of the embodiments, both the second box body and the first box body have a cylindrical structure, and the second box body and the first box body are mated and connected to form an integrated structure.

In one embodiment, the identification part is one or more selected from one-dimensional code, two-dimensional code, label and nameplate.

The above-mentioned assisted reproductive rod assembly realizes that the sample carrier does not deform in a deep low temperature environment and increases the heat transfer effect between the sample carrier and the embryo, increases the vitrification rate and recovery rate of the embryo, and improves the live birth rate of the embryo. In addition, the above-mentioned assisted reproductive rod assembly uses a low-temperature-resistant RFID chip to solve the problems of embryo loss and information loss in traditional technology, so that the embryo information mark is not easy to lose, and the security is good. The above-mentioned assisted reproductive rod components adopt RFID chips, which can realize rapid scanning and identification of the assisted reproductive rod components, and make the assisted reproductive rod components small in size, diverse in shape, good in pollution resistance and durability, and have a large memory capacity of data And security is good.

In the aforementioned assisted reproductive rod assembly, the sample carrier contains graphene, and the sample carrier containing graphene can increase the thermal conductivity of the sample carrier and accelerate the vitrification of the embryo sample.

The above-mentioned assisted reproductive rod assembly can effectively protect the embryo sample by providing a protective cover. When the assisted reproductive rod assembly storing the embryo sample is immersed in liquid nitrogen, the protective cover can protect the embryo sample and prevent the embryo sample from falling off from the assisted reproductive rod assembly, and at least one end of the protective cover is open to ensure that the assisted reproductive rod assembly After immersion in liquid nitrogen, the liquid nitrogen enters into the protective sheath and contacts the sample carrier to realize freezing of the embryo sample.

The above-mentioned assisted reproductive rod assembly achieves effective protection of the sample carrier by the protective cover by setting the sample carrier in a long strip structure and the length of the protective cover is greater than the length of the sample carrier.

The above-mentioned assisted reproductive stem assembly is provided with a columnar structure by setting the sample carrier and the stem handle, and the radial dimension of the sample carrier is smaller than the radial dimension of the stem handle, so that the protective sleeve is sleeved behind the sample carrier Abutting against the rod handle reduces the size of the main body of the rod, which is convenient for storage and cooperation with the rod box part.

The above-mentioned assisted reproductive rod assembly further protects the main body of the rod and the embryo sample on the main body of the rod by providing a rod box part for accommodating the main body of the rod.

The above-mentioned assisted reproductive rod assembly is provided with identification parts on the first box body and/or the second box body, such as one or more of one-dimensional codes, two-dimensional codes, labels and nameplates, to realize the loading A marker for embryo sample information stored on the rod body. The user can quickly obtain the embryo sample information in the carrier box part by scanning the mark with a code scanning gun or a code scanner without opening the carrier box part. In addition, the one-dimensional code, two-dimensional code, label or nameplate stores all the information of the embryo sample, and when the first RFID chip is wrong or cannot be scanned, the one-dimensional code, two-dimensional code, label or nameplate can provide the All information about the embryo sample. Therefore, the straw assembly for assisted reproduction according to the present application can provide multiple ways of obtaining information on the embryo sample.

The above-mentioned assisted reproductive rod assembly further improves the efficiency of obtaining the embryo sample information in the rod box part by setting the second RFID chip on the first box body and/or the second box body, and also improves the Information security of embryo samples inside the rod box assembly.

The above-mentioned assisted reproductive rod assembly can ensure that liquid nitrogen enters the accommodating chamber and contacts the sample carrier to realize freezing by providing a first communication hole connected to the first accommodating tank on the first box body; specifically Specifically, when the assisted reproductive rod assembly is implanted in liquid nitrogen, the first communication hole can be immersed in liquid nitrogen, and the first communication hole can allow liquid nitrogen to flow out during the resuscitation process, which plays an explosion-proof role.

The second box body is provided with a second communication hole connected to the second storage tank, which can ensure that liquid nitrogen enters the storage cavity and contacts with the sample carrier to realize freezing; specifically, when the assisted reproductive carrier When the rod assembly is implanted in liquid nitrogen, the second communication hole can allow liquid nitrogen to immerse, and the second communication hole can allow liquid nitrogen to flow out during the resuscitation process, thereby playing an explosion-proof role.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present application. Those skilled in the art can also obtain other drawings based on these drawings without any creative effort.

Fig. 1 is a schematic diagram of an assisted reproductive rod assembly according to an embodiment of the present application.

Explanation of reference signs

10. Auxiliary reproductive rod assembly; 100. The main body of the rod; 101. The handle of the rod; 102. The sample carrier; 103. The protective cover; 200. The first RFID chip and the second RFID chip; 300. The rod box part; 301, the first box body; 3011, the first communicating hole; 302, the second box body; 3021, the marking area; 20, the embryo sample.

detailed description

In order to make the above-mentioned purpose, features and advantages of the present application more obvious and understandable, the specific implementation manners of the present application will be described in detail below in conjunction with the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the application. However, the present application can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

In the description of the present application, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Back", "Left", "Right", "Vertical", "Horizontal", "Top", "Bottom", "Inner", "Outer", "Clockwise", "Counterclockwise", "Axial" , "radial", "circumferential" and other indicated orientations or positional relationships are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the application and simplifying the description, rather than indicating or implying the referred device or Elements must have certain orientations, be constructed and operate in certain orientations, and thus should not be construed as limiting the application.

In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In the description of the present application, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

In this application, terms such as "installation", "connection", "connection" and "fixation" should be interpreted in a broad sense, for example, it can be a fixed connection or a detachable connection, unless otherwise clearly specified and limited. , or integrated; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components or the interaction relationship between two components, unless otherwise specified limit. Those of ordinary skill in the art can understand the specific meanings of the above terms in this application according to specific situations.

In the present application, unless otherwise clearly specified and limited, a first feature being "on" or "under" a second feature may mean that the first and second features are in direct contact, or that the first and second features are indirect through an intermediary. touch. Moreover, "above", "above" and "above" the first feature on the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. "Below", "beneath" and "beneath" the first feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is less horizontally than the second feature.

It should be noted that when an element is referred to as being “fixed on” or “disposed on” another element, it may be directly on the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or intervening elements may also be present. As used herein, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions are for the purpose of illustration only and are not intended to represent the only embodiment.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field to which this application belongs. The terms used herein in the specification of the application are only for the purpose of describing specific embodiments, and are not intended to limit the application. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

Please refer to FIG. 1 , an embodiment of the present application provides an assisted reproductive rod assembly 10 .

A carrier assembly 10 for assisted reproduction, including a carrier body 100 and a first RFID chip 200 .

Please refer to FIG. 1 , the rod main body 100 includes a rod handle 101 and a sample carrier 102 . Both the rod handle 101 and the sample carrier 102 are made of low temperature resistant materials. The sample carrier 102 contains graphene. In other words, the sample carrier 102 is made of a low temperature resistant material mixed with graphene. The content of graphene in the sample carrier 102 is 5% (wt). The graphene material in the sample carrier 102 can increase the thermal conductivity of the sample carrier 102 and speed up the vitrification of the embryo sample 20 . During preparation, 95% (wt) low temperature resistant material (polyethylene, polypropylene, etc.) used to prepare the sample carrier 102 is mixed with 5% (wt) graphene to prepare the sample carrier 102 . Adding graphene to the sample carrier 102 will not change the original toughness of the sample carrier 102, is not easy to deform, and has fast heat conduction. The live birth rate of the embryo sample 20 after cryopreservation is increased, and the subsequent developmental ability of the embryo is improved. No effect, does not affect the normal growth and differentiation of embryos.

Graphene is a planar film composed of carbon atoms with sp2 hybrid orbitals forming a hexagonal honeycomb lattice. The thickness of the planar film is only one carbon atom thick. Graphene only absorbs 2.3% of light, and its thermal conductivity is as high as ^5300W /m·K, which is higher than that of carbon nanotubes and diamonds. ) is high, and the resistivity is only about 10 ^-6 Ω·cm, which is lower than copper or silver, and has good thermal conductivity. In this embodiment, 5% graphene material is added to prepare the sample carrier 102, so that the prepared sample carrier 102 has good thermal conductivity. The larger the thermal conductivity, the faster the cooling speed, and the higher the probability of vitrification of the embryo sample 20 .

Referring to FIG. 1 , the sample carrier 102 is connected to the rod handle 101 . The sample carrier 102 is provided with a sample storage tank for storing the embryo sample 20.

Please refer to FIG. 1 , a first RFID chip 200 is connected to the carrying handle 101 . The first RFID chip 200 is used to record the information of the embryo sample 20, and the first RFID chip 200 can communicate with the RFID reader.

After the rod handle 101 with the first RFID chip 200 enters the electromagnetic field, it receives radio frequency signals from readers such as RFID readers, code scanners, and code scanners. Embryo sample 20 information in 200, or a signal of a certain frequency is actively sent by the first RFID chip 200, such as RFID reader, code scanner, code scanner and other readers receive the signal, read the information and decode it, Send it to the control system for relevant data processing to achieve the purpose of rapid identification.

The above-mentioned assisted reproductive rod assembly 10 adopts the first RFID chip 200, which can realize the rapid scanning and identification of the assisted reproductive rod assembly 10, and makes the assisted reproductive rod assembly miniaturized, diversified in shape, good in anti-pollution ability and durability, The memory capacity of the data is large and the security is good.

In some embodiments, please refer to FIG. 1 , the carrier body 100 further includes a protective cover 103 . At least one end of the protective cover 103 is open. The protective sleeve 103 is used to sleeve and cooperate with the sample carrier 102 . The above-mentioned assisted reproductive rod assembly 10 can prevent the sample carrier 102 from directly colliding with the outside by providing the protective cover 103, and prevent the sample carrier 102 from shaking when it collides with the outside, causing the embryo sample 20 to fall off, thereby effectively protecting the embryo sample. 20. At least one end of the protective sheath 103 is open, which can ensure that after the assisted reproductive rod assembly is immersed in liquid nitrogen, the protective sheath 103 is also loaded with liquid nitrogen, so that the sample carrier 102 sleeved in the protective sheath 103 can be connected with the sample carrier 102 in the protective sheath 103. Contact with liquid nitrogen to achieve rapid freezing.

In some embodiments, both ends of the protective cover 103 are open.

In some embodiments, the protective cover 103 can be made of transparent material, and the protective cover 103 can be in a transparent state.

In some embodiments, please refer to FIG. 1 , the sample carrier 102 is in the shape of a strip. The sample carrier 102 extends along the axial direction of the rod handle 101 , and the length of the protective sleeve 103 is greater than that of the sample carrier 102 . The aforementioned assisted reproductive rod assembly 10 achieves effective protection of the sample carrier 102 by the protective cover 103 by setting the sample carrier 102 in a strip shape and the length of the protective cover 103 is greater than the length of the sample carrier 102 .

In some embodiments, both the sample carrier 102 and the rod-loading handle 101 have a columnar structure, the radial size of the sample carrier 102 is smaller than the radial size of the rod-loading handle 101, and the protective sleeve 103 is sleeved on the sample carrier 102. It can abut against the rod handle 101 . The radial dimension refers to the radial diameter, or the radial length and width, etc. of the sample carrier 102 , and is specifically set according to the shape of the radial surface of the sample carrier 102 and the stem 101 . For example, when the shapes of the radial surfaces of the sample carrier 102 and the rod-loading handle 101 are both circular, the outer diameter of the sample-carrying member 102 is smaller than the outer diameter of the rod-loading handle 101, and when the sample-carrying member 102 and the rod-loading handle When the shapes of the radial surfaces of 101 are all square, the side length of the sample carrier 102 is smaller than the side length of the rod handle 101 . The above-mentioned assisted reproductive stem assembly 10 adopts a columnar structure by setting the sample carrier 102 and the stem handle 101, and the radial dimension of the sample carrier 102 is smaller than the radial dimension of the stem handle 101, so that the protective cover 103 covers After being arranged on the sample carrier 102 , it can abut against the rod handle 101 , which reduces the size of the rod main body 100 and facilitates storage and cooperation with the rod box component 300 described later.

In some embodiments, please refer to FIG. 1 , the assisted reproduction stem assembly 10 further includes a stem box part 300 . The rod main body 100 is accommodated in the rod case part 300 . The rod cartridge assembly 300 was also immersed in liquid nitrogen. When the rod main body 100 needs to be taken, the rod main body 100 can be taken out together with the rod box part 300. Since the rod main body 100 is accommodated in the rod box part 300, the temperature of the rod main body 100 can be avoided. Fluctuates in a large range to prevent the embryo sample 20 on the carrier rod main body 100 from thawing in advance. The rod box component 300 includes a first box body 301 and a second box body 302 . The first box body 301 has a first accommodating groove, and the second box body 302 has a second accommodating groove. The first box body 301 and the second box body 302 can be connected to realize the communication between the first accommodating groove and the second accommodating groove to form an accommodating cavity. The accommodating cavity is used for accommodating the rod body 100 . The assisted reproduction carrier assembly 10 further protects the carrier body 100 and the embryo sample 20 on the carrier body 100 by providing the carrier box part 300 for accommodating the carrier body 100 .

In some embodiments, the first box body 301 and/or the second box body 302 is provided with a marking area 3021 . The marking area 3021 is provided with an identification part, wherein the identification part can be one or more selected from a one-dimensional code, a two-dimensional code, a label and a nameplate. The above-mentioned assisted reproductive rod assembly 10 can realize the The embryo sample 20 information stored on 100 is marked, so that the user can quickly obtain the information of the embryo sample 20 in the rod box part 300 by scanning the mark with a code scanner or a code scanner without opening the rod box part 300 . In addition, the one-dimensional code, two-dimensional code, label or nameplate can store all the information of the embryo sample 20, when the first RFID chip 200 has an error or cannot scan, the one-dimensional code, two-dimensional code, label or nameplate All information of the embryo sample 20 can be provided. Therefore, the assisted reproductive straw assembly according to the present application can provide multiple ways of obtaining information about the embryo sample 20 .

For example, in a specific embodiment, the first box body 301 and/or the second box body 302 is provided with a marking area 3021 . Referring to FIG. 1 , in FIG. 1 , only the marking area 3021 is provided on the outer wall of the second box body 302 . It can be understood that in other embodiments, a one-dimensional code, a two-dimensional code, a label or a nameplate may also be provided on the first box body 301 .

In some embodiments, the second RFID chip 200 is connected to the first box body 301 and/or the second box body 302 . The above-mentioned assisted reproductive rod assembly 10 further improves the efficiency of obtaining the information of the embryo sample 20 in the rod box part 300 by arranging the second RFID chip 200 on the first box body 301 and/or the second box body 302, and at the same time The information security of the embryo sample 20 in the carrier box part 300 is also improved.

In some embodiments, please refer to FIG. 1 , the first box body 301 is provided with a first communicating hole 3011 communicating with the first accommodating groove. The first communication hole 3011 can ensure that liquid nitrogen enters the accommodating cavity and contacts with the sample carrier 102 to realize freezing; specifically, when the assisted reproductive rod assembly is implanted in liquid nitrogen, the first communication hole 3011 can supply liquid nitrogen Immersed, the first communication hole 3011 can allow liquid nitrogen to flow out during the resuscitation process, which plays an explosion-proof role.

In some embodiments, the second box body 302 is provided with a second communicating hole communicating with the second accommodating groove. The second communication hole is not shown in accompanying drawing 1 . The second communication hole can ensure that liquid nitrogen enters the accommodating cavity and contacts with the sample carrier 102 to realize freezing; specifically, when the assisted reproductive rod assembly is implanted in liquid nitrogen, the second communication hole can allow liquid nitrogen to immerse, During the resuscitation process, the second communication hole can allow liquid nitrogen to flow out, which plays an explosion-proof role.

Referring to FIG. 1 , in FIG. 1 , only the first communicating hole 3011 communicating with the first accommodating groove is provided on the first box body 301 . Since the first communication hole 3011 and the second communication hole may have the same function and shape, the description of the first communication hole 3011 may be applied to the second communication hole, so that the second communication hole is not shown.

In some embodiments, both the second box body 302 and the first box body 301 have a cylindrical structure. The second box body 302 is mated with the first box body 301 to form an integrated structure, and the mating connection methods include various connection methods such as slot snap-fit connection and snap snap-fit connection. That is, the second box body 302 and the first box body 301 can be closed or opened in cooperation. That is to say, in one of the embodiments, the shape of the connection between the second box body 302 and the first box body 301 is smoothly transitioned, which has better continuity and presents an integrated appearance. It can be understood that in other embodiments, the structure and shape of the second box body 302 and the first box body 301 are not limited to the above cylindrical structure, and the structure and shape of the second box body 302 and the first box body 301 can also be Square box structure, etc.

The above-mentioned assisted reproductive rod assembly 10 realizes that the sample carrier 102 is not deformed in a deep low temperature environment and increases the heat transfer effect between the sample carrier 102 and the embryo, increases the vitrification rate and recovery rate of the embryo, and improves the viability of the embryo. Yield. In addition, the above-mentioned assisted reproductive carrier assembly 10 uses the low temperature resistant RFID chip 200 to solve the problems of embryo loss and information loss in the traditional technology, so that the embryo information mark is not easy to lose, and the security is good.

The above-mentioned assisted reproduction carrier assembly 10 was applied to animals for experiments. The experimental process and results are as follows:

Freezing: After the ovulation induction of the mice, the male and female are kept in the same cage overnight. The embryonic cells are taken the next day, and the embryonic cells are cultured in vitro for 84 hours to form fertilized embryos. The fertilized embryos are collected, and the embryos are treated with the balance solution for 5 minutes, and then treated with the freezing solution for 1 minute. Then the embryos are loaded onto the above-mentioned assisted reproduction carrier rod assembly 10 to form an embryo sample 20, which is put into liquid nitrogen for storage for 24 hours.

Thawing: When thawing, first place the embryo sample 20 on the assisted reproductive carrier assembly 10 in the thawing solution at 37°C for 1 minute, then transfer it to the diluent and keep it for 3 minutes, then transfer it to the cleaning solution 1 and wash it for 5 minutes, and wash it in the cleaning solution 2. Wash for 5 minutes. Then the embryo sample 20 was transferred to the culture medium and cultured for 24 hours, and the thawing recovery rate and damage rate of the embryo sample 20 were counted.

Control group 1: Repeat the above experimental process using a traditional closed carrier (the sample carrier 102 does not contain graphene).

Control group 2: The above animal experiment was repeated using a conventional open carrier (the sample carrier 102 does not contain graphene and has no protective sleeve).

Table 1 shows the thawing recovery rate and injury rate of 20 embryo samples in the three groups.

Table 1 Three groups of embryo samples 20 thawing recovery rate, injury rate

It can be seen from Table 1 that the embryo thawing recovery rate of the embryo sample 20 processed by the assisted reproduction carrier assembly 10 of the present application is higher than the embryo thawing recovery rate of the embryo sample 20 processed by the traditional closed carrier and the open carrier. The embryo damage rate of the embryo sample 20 processed by the assisted reproduction carrier assembly 10 of the present application is much lower than the embryo damage rate of the embryo sample 20 processed by the traditional closed carrier and the open carrier.

The technical features of the above-mentioned embodiments can be combined arbitrarily. To make the description concise, all possible combinations of the technical features in the above-mentioned embodiments are not described. However, as long as there is no contradiction in the combination of these technical features, should be considered as within the scope of this specification.

The above-mentioned embodiments only express several implementation modes of the present application, and the description thereof is relatively specific and detailed, but should not be construed as limiting the patent scope of the present application. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the scope of protection of the patent application should be based on the appended claims.

Claims

An assisted reproductive rod assembly, characterized in that it includes a rod main body and a first RFID chip;

Wherein, the main body of the carrier rod includes a rod handle and a sample carrier connected to the handle of the carrier rod, the sample carrier contains graphene, and the sample carrier is provided with a sample storage for embryo sample storage Groove; the first RFID chip is connected to the carrying rod handle, the first RFID chip is used to record embryo sample information, and the first RFID chip can communicate with the RFID reader.
The rod assembly for assisted reproduction according to claim 1, wherein the rod body further comprises a protective sleeve, at least one end of which is open, and the protective sleeve can be sleeved and fitted with the sample carrier.
The rod assembly for assisted reproduction according to claim 2, wherein both ends of the protective sleeve are open.
The assisted reproductive rod assembly according to claim 2, wherein the sample carrier is in the shape of a strip, and the sample carrier extends along the axial direction of the rod handle.
The rod assembly for assisted reproduction according to claim 2, wherein the length of the protective sheath is greater than the length of the sample carrier.
The rod assembly for assisted reproduction according to claim 2, wherein the protective cover is made of transparent material.
The assisted reproductive rod assembly according to any one of claims 2-6, characterized in that, both the sample carrier and the rod handle have a columnar structure, and the radial dimension of the sample carrier is smaller than the The radial dimension of the rod-loading handle, the protective sleeve is sheathed on the sample carrier and abuts against the rod-loading handle.
The rod assembly for assisted reproduction according to any one of claims 1-6, further comprising a rod box part, the rod box part includes a first box body and can cooperate with the first box body The connected second box body, the first box body has a first accommodating groove, and the second box body has a second accommodating groove; when the first box body and the second box body are mated and connected , the first accommodating groove communicates with the second accommodating groove to form an accommodating cavity for accommodating the main body of the carrier rod.
The assisted reproductive rod assembly according to claim 8, wherein an identification part is provided on the first box body and/or the second box body.
The assisted reproductive rod assembly according to claim 8, wherein a second RFID chip is connected to the first box body and/or the second box body.
The rod assembly for assisted reproduction according to claim 8, wherein a first communicating hole communicating with the first accommodating groove is provided on the first box body.
The rod assembly for assisted reproduction according to claim 8, wherein a second communicating hole communicating with the second accommodating groove is provided on the second box body.
The assisted reproductive rod assembly according to claim 8, wherein the second box body and the first box body both have a cylindrical structure, and the second box body cooperates with the first box body The connection is a one-piece structure.
The post assembly for assisted reproduction according to claim 8, wherein the identification part is one or more selected from a one-dimensional code, a two-dimensional code, a label and a nameplate.