WO2022244714A1 - 生検デバイスおよび検体採取方法 - Google Patents

生検デバイスおよび検体採取方法 Download PDF

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Publication number
WO2022244714A1
WO2022244714A1 PCT/JP2022/020325 JP2022020325W WO2022244714A1 WO 2022244714 A1 WO2022244714 A1 WO 2022244714A1 JP 2022020325 W JP2022020325 W JP 2022020325W WO 2022244714 A1 WO2022244714 A1 WO 2022244714A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
wire
drill body
biopsy device
longitudinal direction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2022/020325
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
昌一郎 川除
祥平 鎌田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Original Assignee
Olympus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corp filed Critical Olympus Corp
Priority to CN202280035231.9A priority Critical patent/CN117320637A/zh
Priority to JP2023522644A priority patent/JP7557621B2/ja
Publication of WO2022244714A1 publication Critical patent/WO2022244714A1/ja
Priority to US18/383,932 priority patent/US20240050077A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/04—Endoscopic instruments, e.g. catheter-type instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0208—Biopsy devices with actuators, e.g. with triggered spring mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/04—Endoscopic instruments, e.g. catheter-type instruments
    • A61B2010/045—Needles

Definitions

  • the distal end portion of the needle described in Patent Documents 1 and 2 is pierced into living tissue while rotating. If the needle is not properly rotated, the helical distal end will not properly penetrate the tissue and it will be difficult to collect a sufficient amount of specimen.
  • the present invention has been made in view of the circumstances described above, and provides a biopsy device and a specimen that can appropriately pierce biological tissue with a spiral distal end portion and reliably collect a sufficient amount of specimen. The purpose is to provide a collection method.
  • FIG. 2 is an overall configuration diagram of the biopsy device according to the first embodiment, showing a state in which the engagement between the threaded portion and the engaging portion is released;
  • FIG. 1B is a view of the biopsy device of FIG. 1A with the wire positioned by the positioning mechanism and the engaging portion engaged with the threaded portion;
  • 1B is an enlarged view of the distal portion of the biopsy device of FIG. 1A illustrating the drill body;
  • FIG. 1B is an enlarged view of the operating portion of the biopsy device of FIG. 1A illustrating the rotation mechanism;
  • FIG. 4 is a flow chart of a sample collection method according to the first embodiment;
  • FIG. 4 is a diagram for explaining the operation of the biopsy device in step S1 of the sample collection method;
  • FIG. 4 is a diagram for explaining the operation of the biopsy device in step S2 of the sample collection method;
  • FIG. 4 is a diagram for explaining the operation of the biopsy device in step S3 of the sample collection method;
  • FIG. 4 is a diagram for explaining the operation of the biopsy device in step S4 of the sample collection method;
  • FIG. 4 is a diagram for explaining the operation of the biopsy device in step S5 of the sample collection method;
  • FIG. 10 is an overall configuration diagram of the biopsy device according to the second embodiment, showing a state in which the wire is positioned by the positioning mechanism and the engaging portion is engaged with the threaded portion;
  • 8 is a flowchart of a sample collection method according to the second embodiment;
  • FIG. 4 is a diagram for explaining the operation of the biopsy device in step S11 of the sample collection method;
  • FIG. 11 is a diagram explaining the operation of the biopsy device of FIG. 10 in step S11 of the sample collection method;
  • FIG. 11 is a diagram explaining the operation of the biopsy device of FIG. 10 in step S21 of the sample collection method;
  • FIG. 11 is a diagram explaining the operation of the biopsy device of FIG. 10 in step S31 of the sample collection method;
  • FIG. 11 is a diagram explaining the operation of the biopsy device of FIG. 10 in step S41 of the sample collection method;
  • FIG. 11 is a diagram explaining the operation of the biopsy device of FIG. 10 in step S42 of the sample collection method;
  • FIG. 11 is a diagram explaining the operation of the biopsy device of FIG. 10 in step S51 of the sample collection method;
  • FIG. 11 is a diagram explaining the operation of the biopsy device of FIG. 10 in step S11 of the sample collection method;
  • FIG. 11 is a diagram explaining the operation of the biopsy device of FIG. 10 in step S21 of the sample collection method;
  • FIG. 11 is a diagram explaining the operation of the biopsy device
  • the needle tip 2a and the drill body 6 are housed within the sheath 4 when the slider 8 and the knob 9 are arranged in the initial position.
  • the operator advances needle 2 and wire 3 distally, respectively, by pressing slider 8 and knob 9 distally to move needle tip 2a and drill body 6 into the sheath. 4 can protrude from the distal end. Also, the operator can retract the needle 2 and the wire 3 proximally by pulling the slider 8 and the knob 9 proximally.
  • step S4 the operator engages the engaging portion 12 with the threaded portion 11 and then rotates the knob 9 to move the needle 2 longitudinally while advancing the drill body 6 longitudinally. so that the drill body 6 and the needle 2 are simultaneously pierced into the living tissue T to a desired depth (a predetermined distance) (FIG. 5D).
  • the drill body 6 advances in the longitudinal direction with a lead equal to the predetermined pitch P1 while rotating about the longitudinal axis A by the rotating mechanism 10 consisting of the threaded portion 11 and the engaging portion 12 .
  • the drill body 6 advances while taking the biological tissue T into the spiral groove and cutting it spirally.
  • the cut string-like body tissue T is ejected proximally along the spiral groove and taken into the needle 2 .
  • the drill body 6 moves forward while pushing the living tissue T away. Therefore, it is difficult to efficiently take the living tissue T into the spiral groove and cut the living tissue T spirally with the drill body 6 . If the rotation speed is too fast for advancing the drill body 6, the drill body 6 moves forward while slicing the body tissue T finely. Therefore, it is difficult to cut the living tissue T in the shape of a continuous string and to take the living tissue T into the needle 2 .
  • step S4 while the wire 3 is positioned with respect to the needle 2 by the positioning mechanism 14, the needle 2 is punctured into the biological tissue T at the same speed as the drill body 6. As a result, the living tissue T cut by the drill body 6 and discharged proximally can be efficiently collected into the needle 2 .
  • step S51 the operator releases the engagement between the threaded portion 11 and the engaging portion 12, and then simultaneously pulls the slider 8 and the knob 9 to move the needle 2 together with the drill body 6 into the living tissue. Withdraw from T and retract completely within sheath 4 (Fig. 8F).
  • step S61 the operator withdraws the biopsy device 1 from the body by pulling out the sheath 4 housing the drill body 6 and the needle 2 from the treatment instrument channel. As a result, the living tissue T taken into the needle 2 can be collected as a sample.
  • the drill body 6 is solid, but instead, the drill body 6 may be hollow as shown in FIGS. 9A and 9B.
  • the drill body 6 consists of a fine wire wound into a helical coil.
  • the biological tissue T is also taken into the inside of the drill body 6 through the gaps between the thin wires and the opening of the distal end face, so more specimens can be collected.
  • the biopsy device of FIG. 10 is used in the specimen collection method of the second embodiment, as shown in FIGS. 11A-11F.
  • step S11 shown in FIG. 11A as shown in FIG. 11B, the needle 2 and the wire 3 are simultaneously advanced by simultaneously pressing the slider 8 and the knob 9 with the locking portions 8a and 9a released (step S21). ).
  • step S21 the needle 2 and the wire 3 are simultaneously advanced by simultaneously pressing the slider 8 and the knob 9 with the locking portions 8a and 9a released (step S21).
  • the slider 8 is fixed by the lock portion 8a, and the knob 9 is rotated to advance the drill body 6 to puncture the living tissue T (steps S31 and S41). ).
  • the biopsy device of FIG. 13 includes a second wire 15 inserted into the wire 3 as the release mechanism 13.
  • the wire 3 is therefore at least partially hollow.
  • the rotation mechanism 10 has an engaging portion 12 provided on the first wire (wire-side member) 3 and a threaded portion 11 provided on the needle (peripheral member) 2 .
  • the engaging portion 12 is a protrusion that protrudes from the outer peripheral surface of the first wire 3, and the protrusion may be a screw thread.
  • the threaded portion 11 is a female threaded portion having a thread groove provided on the inner peripheral surface of the needle 2 .

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Surgical Instruments (AREA)
  • Endoscopes (AREA)
PCT/JP2022/020325 2021-05-18 2022-05-16 生検デバイスおよび検体採取方法 Ceased WO2022244714A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202280035231.9A CN117320637A (zh) 2021-05-18 2022-05-16 活检器件及检体采集方法
JP2023522644A JP7557621B2 (ja) 2021-05-18 2022-05-16 生検デバイスおよび検体採取方法
US18/383,932 US20240050077A1 (en) 2021-05-18 2023-10-26 Biopsy device and specimen collection method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163189793P 2021-05-18 2021-05-18
US63/189,793 2021-05-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US18/383,932 Continuation US20240050077A1 (en) 2021-05-18 2023-10-26 Biopsy device and specimen collection method

Publications (1)

Publication Number Publication Date
WO2022244714A1 true WO2022244714A1 (ja) 2022-11-24

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Family Applications (2)

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PCT/JP2022/020325 Ceased WO2022244714A1 (ja) 2021-05-18 2022-05-16 生検デバイスおよび検体採取方法
PCT/JP2022/020318 Ceased WO2022244711A1 (ja) 2021-05-18 2022-05-16 生検デバイスおよび検体採取方法

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US (1) US20240050077A1 (https=)
JP (1) JP7557621B2 (https=)
CN (1) CN117320637A (https=)
WO (2) WO2022244714A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025197289A1 (ja) * 2024-03-18 2025-09-25 テルモ株式会社 組織採取針

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012235878A (ja) * 2011-05-11 2012-12-06 Terumo Corp 生検デバイス
US20140026693A1 (en) * 2012-07-25 2014-01-30 Cook Medical Technologies Llc Rotational drive system for a biopsy member

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1013974A3 (nl) * 2001-02-16 2003-01-14 Janssens Jacques Phillibert Inrichting voor het nemen van een weefselstaal.
US7326203B2 (en) * 2002-09-30 2008-02-05 Depuy Acromed, Inc. Device for advancing a functional element through tissue
US8696671B2 (en) * 2005-07-29 2014-04-15 Vertos Medical Inc. Percutaneous tissue excision devices
JP5647775B2 (ja) * 2009-07-27 2015-01-07 Hoya株式会社 内視鏡用生検鉗子
DK2531122T3 (da) * 2010-02-02 2014-06-23 Medi Globe Gmbh Anordning til fastlæggelse af indtrængningsdybden af en rør- eller stangformet skydedel i en optagedel og medicinsk håndstykke, der anvender sådanne anordninger
JP2014200410A (ja) * 2013-04-03 2014-10-27 テルモ株式会社 生検デバイス
JP6097826B2 (ja) * 2013-05-27 2017-03-15 富士フイルム株式会社 組織採取装置
JP6430697B2 (ja) * 2013-11-01 2018-11-28 国立大学法人千葉大学 内視鏡用の穿刺針
WO2016027523A1 (ja) * 2014-08-19 2016-02-25 オリンパス株式会社 医療用処置具
JP6121085B1 (ja) * 2015-06-10 2017-04-26 オリンパス株式会社 生検針
CN112423823B (zh) * 2018-07-19 2022-07-29 奥林巴斯株式会社 穿刺针

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012235878A (ja) * 2011-05-11 2012-12-06 Terumo Corp 生検デバイス
US20140026693A1 (en) * 2012-07-25 2014-01-30 Cook Medical Technologies Llc Rotational drive system for a biopsy member

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JP7557621B2 (ja) 2024-09-27
US20240050077A1 (en) 2024-02-15
JPWO2022244714A1 (https=) 2022-11-24
CN117320637A (zh) 2023-12-29
WO2022244711A1 (ja) 2022-11-24

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