WO2022227724A1 - 试剂混匀和装载装置以及免疫检测设备 - Google Patents

试剂混匀和装载装置以及免疫检测设备 Download PDF

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Publication number
WO2022227724A1
WO2022227724A1 PCT/CN2022/072672 CN2022072672W WO2022227724A1 WO 2022227724 A1 WO2022227724 A1 WO 2022227724A1 CN 2022072672 W CN2022072672 W CN 2022072672W WO 2022227724 A1 WO2022227724 A1 WO 2022227724A1
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Prior art keywords
loading
mixing
reagent
rotating member
transmission
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PCT/CN2022/072672
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English (en)
French (fr)
Inventor
赖云飞
黄修涛
张福星
肖育劲
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深圳市亚辉龙生物科技股份有限公司
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Priority to EP22794206.7A priority Critical patent/EP4332583A1/en
Publication of WO2022227724A1 publication Critical patent/WO2022227724A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00524—Mixing by agitating sample carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents

Definitions

  • the invention relates to the fields of biological detection and diagnosis, in particular to a reagent mixing and loading device and an immune detection device.
  • Immunodiagnostic technology is an important diagnostic tool for tumors, diabetes, abnormal gonadal secretion and other diseases.
  • immunodiagnostic techniques such as chemiluminescence immunoassay technology have the advantages of short reaction time, simple operation and high diagnostic efficiency, and have been widely used in modern medicine. and research fields.
  • the chemiluminescence immunoassay system mainly includes: a cuvette storage and transmission system, a sample loading system, a reagent loading system, a sample adding system, an incubation system, a centrifugal cleaning system and a luminescence reading system.
  • the reagent loading system needs to manually complete the loading and unloading of the reagent cartridge in a shutdown state, so that the running test needs to be stopped, which affects the test time and results.
  • some reagents may be used up, and different test items use different reagents.
  • reagents need to be loaded or replaced.
  • it is necessary to stop the operation. and reprints are prone to issues such as jams and crashes that affect ongoing tests.
  • a reagent mixing and loading device includes a transmission mechanism, a mixing mechanism, a loading mechanism and a driving mechanism
  • the transmission mechanism includes a first rotating member and a second rotating member, and the first rotating member is rotatably connected with multiple
  • the mixing mechanisms are arranged at intervals, the first rotating member is sleeved on the second rotating member and can rotate synchronously with the second rotating member, and the driving mechanism is connected with the second rotating member to use to drive the second rotating member to rotate;
  • the mixing mechanism includes a mixing column, a mixing transmission member and a mixing stopper, and the mixing transmission member is sleeved and connected to the mixing column and is connected with the mixing column.
  • the second rotating member abuts and cooperates with the second rotating member to rotate relative to the second rotating member;
  • the loading mechanism includes a loading box and a loading matching member, the loading box has a reagent hole for placing the loading box, and the loading matching
  • the mixing stopper is rotatably disposed in the reagent hole for carrying the loading box, and the mixing limiter can cooperate with the loading matching member and push the loading matching member to rotate.
  • the mixing limiter includes at least two elastic limit arms arranged at intervals, the elastic limit arms are connected to the mixing column; the loading fitting has at least two intervals A loading limit arm is provided, the loading limit arm is at least partially located outside the reagent hole, and when the loading limit arm and the elastic limit arm are misaligned, the loading limit arm and the elastic limit arm The limit arm abuts.
  • the loading fitting further includes a bearing plate, the bearing plate is rotatably disposed in the reagent hole, and the loading limit arm is connected to the bearing plate and protrudes from the reagent hole .
  • the number of the loading limit arms is multiple, and the multiple loading limit arms are distributed at equal intervals on the first circumference.
  • the number of the elastic limiting arms is multiple, and the multiple elastic limiting arms are distributed at equal intervals on the second circumference.
  • the maximum diameter of the first circumference is smaller than the maximum diameter of the second circumference and greater than the minimum diameter of the second circumference
  • the elastic limit arm faces one end of the loading limit arm
  • the inner wall of the device has a guide abdication surface, which is in the shape of an outwardly facing slope.
  • the second rotating member is a gear
  • the mixing transmission member is a mixing gear
  • the second rotating member meshes with the mixing transmission member
  • the transmission mechanism further includes a first transmission wheel, a transmission belt and a second transmission wheel, the first transmission wheel and the second transmission wheel are connected by the transmission belt, and the second transmission wheel Connected to the drive shaft of the drive mechanism, the second transmission wheel is connected to the second rotating member through the transmission shaft.
  • the number of the loading mechanisms is multiple;
  • the reagent mixing and loading device further includes a loading and transferring mechanism, which is connected to the loading box for driving the loading box to move.
  • An embodiment of the present invention also provides an immune detection device.
  • An immunodetection equipment includes the reagent mixing and loading device.
  • the above-mentioned reagent mixing and loading device can not only realize the normal mixing of the reagents, but also realize the smooth introduction of the reagent cartridge without the problems of sticking and collision in the state of non-stop, so as to improve the test progress.
  • the structure of the mixing mechanism is simple, and the mixing transmission parts of the mixing mechanism are elastic.
  • the elastic mold opening of plastic materials can be used for production, and mass production can be achieved by opening the plastic mold, with low price and cost. Low.
  • the maximum diameter of the first circumference is set to be smaller than the maximum diameter of the second circumference and greater than the minimum diameter of the second circumference, so that the loading limit arm can be guaranteed when loading.
  • the entry position of the mixing transmission member is within the end face of the elastic limit arm. Since the inner wall of the elastic limit arm toward the end of the loading limit arm has a guide and abdicate surface, the loading limit arm can give way along the guide. The slope of the surface gradually moves down to open the elastic limit arm. With the rotation of the mixing column, the loading limit arm and the elastic limit arm can gradually be in a state of mutual dislocation and clamping. At this time, the elastic limit arm The pressing force of the loading limit arm disappears, and the elastic limit arm is reset. With the rotation of the mixing column, the elastic limit arm pushes the loading limit arm to rotate to realize mixing.
  • the multiple loading mechanisms can improve the efficiency of reagent loading and realize the loading of multiple reagent cartridges. For example, during the test, some reagents are used up, and different test items use different reagents, all need to load or replace the reagents. At this time, there is no need to stop the machine, and the reagents can be picked up by the reagent cartridge grabbing mechanism. Different kits are loaded, and the reprint is not prone to problems such as jamming and collision, and does not affect the ongoing test.
  • FIG. 1 is a schematic diagram of a reagent mixing and loading device according to an embodiment of the present invention
  • FIG. 2 is a schematic diagram when the loading fitting and the mixing limiter are facing each other according to an embodiment of the present invention
  • FIG. 3 is a schematic diagram when the loading fitting and the mixing limiter are completely misaligned according to an embodiment of the present invention
  • FIG. 4 is a schematic diagram of a partial structure of a mixing stopper according to an embodiment of the present invention.
  • Reagent mixing and loading device 100, transmission mechanism; 110, first rotating part; 120, second rotating part; 200, mixing mechanism; 210, mixing column; 220, mixing transmission part; 230, mixing 231, the elastic limit arm; 2311, the guide yield surface; 300, the loading mechanism; 310, the loading box; 320, the loading fitting; 321, the loading limit arm; 400, the driving mechanism.
  • first and second are only used for descriptive purposes, and should not be construed as indicating or implying relative importance or implying the number of indicated technical features. Thus, a feature delimited with “first”, “second” may expressly or implicitly include at least one of that feature.
  • plurality means at least two, such as two, three, etc., unless otherwise expressly and specifically defined.
  • the terms “installed”, “connected”, “connected”, “fixed” and other terms should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection , or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between the two elements, unless otherwise specified limit.
  • installed may be a fixed connection or a detachable connection , or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between the two elements, unless otherwise specified limit.
  • a first feature "on” or “under” a second feature may be in direct contact between the first and second features, or the first and second features indirectly through an intermediary touch.
  • the first feature being “above”, “over” and “above” the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is level higher than the second feature.
  • the first feature being “below”, “below” and “below” the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature has a lower level than the second feature.
  • an embodiment of the present invention provides a reagent mixing and loading device 10 .
  • a reagent mixing and loading device 10 includes a transmission mechanism 100 , a mixing mechanism 200 , a loading mechanism 300 and a driving mechanism 400 .
  • the transmission mechanism 100 includes a first rotating member 110 and a second rotating member 120 .
  • the first rotating member 110 is rotatably connected with a plurality of mixing mechanisms 200 arranged at intervals, and the plurality of mixing mechanisms 200 arranged at intervals are distributed along the same circumference.
  • the first rotating member 110 is provided with a plurality of accommodating holes distributed along the circumference, and each accommodating hole is fitted with a mixing mechanism 200.
  • the first rotating member 110 is sleeved on the second rotating member 120 and can rotate synchronously with the second rotating member 120 .
  • the second rotating member 120 can be set with corresponding functions as required.
  • the driving mechanism 400 is connected with the second rotation for driving the second rotating member 120 to rotate.
  • the mixing mechanism 200 includes a mixing column 210 , a mixing transmission member 220 and a mixing limiting member 230 .
  • the mixing column 210 is rotatably disposed in the accommodating hole.
  • the mixing transmission member 220 is sleeved and connected to the mixing column 210 and abuts and cooperates with the second rotating member 120 to realize the opposite rotation with the second rotating member 120 . Since the second rotating member 120 and the mixing transmission member 220 are in abutting fit, such as rolling fit, gear meshing, etc., the mixing transmission member 220 can rotate relative to the rotation of the second rotating member 120 .
  • the preparation material of the mixing mechanism 200 may be engineering plastics. At this time, the mixing mechanism 200 is light in weight, simple in structure, and easy to open and form. It can be understood that, in other embodiments, the preparation material of the mixing mechanism 200 is not limited to the above, and the preparation material of the mixing mechanism 200 may also be a metal material.
  • the loading mechanism 300 includes a loading box 310 and a loading fitting 320 .
  • the cassette has reagent wells for the cassette 310 to be placed.
  • the loading fitting 320 is rotatably disposed in the reagent hole for carrying the loading box 310 , and the mixing stopper 230 can cooperate with the loading fitting 320 and push the loading fitting 320 to rotate.
  • the loading box 310 when loading the loading box 310, the loading box 310 is grasped by the loading box 310 grasping mechanism to the position of the mixing mechanism 200, and the mixing stopper 230 can cooperate with the loading fitting 320, for example, abut each other, when mixing
  • the mixing stopper 230 rotates with the mixing column 210, the mixing stopper 230 can push the mixing stopper 230 to rotate, and the rotation of the mixing stopper 230 can drive the loading fitting 320 and the loading box it carries. Rotate at 310 to realize the mixing of the reagents.
  • the mixing limiting member 230 includes at least two elastic limiting arms 231 arranged at intervals.
  • the elastic limiting arm 231 is connected to the mixing column 210 .
  • the loading fitting 320 has at least two loading limiting arms 321 arranged at intervals.
  • the loading limit arm 321 is located at least partially outside the reagent well.
  • the loading limit arm 321 and the elastic limit arm 231 are displaced, the loading limit arm 321 abuts against the elastic limit arm 231 .
  • the loading box 310 is grasped by the loading box 310 grasping mechanism to the position of the mixing mechanism 200.
  • the loading limit arm 321 may not directly reach the position of complete dislocation with the elastic limit arm 231.
  • the elastic limit arm 231 is elastic, when the loading limit arm 321 moves down, it just abuts against the elastic limit arm 231 (the loading limit arm 321 is completely aligned with the elastic limit arm 231). 2), the loading limit arm 321 can squeeze and gradually open the elastic limit arm 231, and as the mixing column 210 rotates, the loading limit arm 321 is gradually displaced from the elastic limit arm 231, Until the loading limit arm 321 and the elastic limit arm 231 are completely dislocated (please refer to FIG.
  • the elastic limit arm 231 is reset, and in the radial direction, the load limit arm and the elastic limit arm 231 can The abutment and cooperation cause interference, the loading limit arm 321 can rotate with the rotation of the elastic limit arm 231, and the rotation of the loading limit arm 321 can drive the loading box 310 it carries to rotate to realize the mixing of the reagents.
  • the load fitting 320 also includes a carrier plate.
  • the carrier plate is rotatably disposed in the reagent hole, and the loading limit arm 321 is connected to the carrier plate and protrudes from the reagent hole.
  • the reagent holes are arranged along the vertical direction of the loading box 310, the bearing plate is rotatably arranged in the reagent holes, the bearing plate is close to the bottom of the reagent holes, one end of the loading limit arm 321 is connected to the bottom surface of the bearing plate, and the loading limit The other end of the bit arm 321 extends toward the outside of the reagent well.
  • the number of loading limit arms 321 is multiple.
  • the plurality of loading limit arms 321 are distributed at equal intervals on the first circumference.
  • the number of elastic limiting arms 231 is multiple.
  • the plurality of elastic limiting arms 231 are distributed at equal intervals on the second circumference.
  • the elastic limit arm 231 since the loading limit arm 321 has a certain thickness, the elastic limit arm 231 also has a certain thickness, therefore, the first circumference where the loading limit arm 321 is located is in a ring shape, and the elastic limit arm 231 The second circumference on which it is located is also annular in shape. The largest diameter of the first circumference is smaller than the largest diameter of the second circumference and greater than the smallest diameter of the second circumference.
  • the inner wall of the end of the elastic limiting arm 231 facing the loading limiting arm 321 has a guide abdication surface 2311 , and the guide ablution surface 2311 is in the shape of an outward slope.
  • This arrangement can ensure that the loading limit arm 321 descends from directly above the elastic limit arm 231.
  • the loading limit arm 321 and the elastic limit arm 231 are not completely misaligned (please refer to FIG. 2), the loading limit The positioning arm 321 will slowly contact the elastic limiting arm 231, and the loading limiting arm 321 descends along the guiding surface 2311, and gradually squeezes the elastic limiting arm 231 to open.
  • the mixing column 210 rotates, the loading limit The arm 321 is gradually dislocated from the elastic limiting arm 231 until the loading limiting arm 321 and the elastic limiting arm 231 are completely dislocated (please refer to FIG. 3 ).
  • the second rotating member 120 is a gear
  • the mixing transmission member 220 is a mixing gear
  • the second rotating member 120 is engaged with the mixing transmission member 220 .
  • the second rotating member 120 and the mixing transmission member 220 are engaged with each other, so that the transmission stability can be improved.
  • the transmission mechanism 100 further includes a first transmission wheel, a transmission belt and a second transmission wheel.
  • the first drive pulley, the drive belt and the second drive pulley are not shown in the drawings.
  • the first transmission wheel is connected to the second transmission wheel through a transmission belt
  • the second transmission wheel is connected to the drive shaft of the driving mechanism 400
  • the second transmission wheel is connected to the second rotating member 120 through the transmission shaft.
  • the number of loading mechanisms 300 is multiple.
  • the multiple loading mechanisms 300 can improve the efficiency of reagent loading and realize the loading of multiple reagent cartridges. For example, during the test, some reagents are used up, and different test items use different reagents, all need to load or replace the reagents. At this time, there is no need to stop the machine, and the reagents can be picked up by the reagent cartridge grabbing mechanism. Different kits are loaded, and the reprint is not prone to problems such as jamming and collision, and does not affect the ongoing test.
  • the reagent mixing and loading device 10 further includes a loading and transferring mechanism, which is connected to the loading box 310 for driving the loading box 310 to move.
  • the above-mentioned reagent mixing and loading device 10 can not only realize the normal mixing of the reagents, but also realize the smooth introduction of the reagent cartridge without the problems of sticking and collision without stopping the machine, so as to improve the test progress.
  • An embodiment of the present invention also provides an immune detection device.
  • An immunoassay equipment includes a reagent mixing and loading device 10 .
  • the structure of the mixing mechanism 200 is simple, and the mixing transmission member 220 of the mixing mechanism 200 is elastic.
  • the elastic mold opening of plastic materials can be used for production, and mass production can be achieved by opening the plastic mold. Inexpensive and low cost.
  • the maximum diameter of the first circumference is set to be smaller than the maximum diameter of the second circumference and greater than the minimum diameter of the second circumference, so that the loading limit arm 321 can be guaranteed when loading.
  • the entry position of the mixing transmission member 220 is within the end face of the elastic limit arm 231 , since the inner wall of the elastic limit arm 231 toward the end of the loading limit arm 321 has a guiding surface 2311 , therefore, the loading limit arm 321 It can gradually move down along the slope of the guide and give way surface 2311 to open the elastic limit arm 231. With the rotation of the mixing column 210, the loading limit arm 321 and the elastic limit arm 231 can gradually be in mutual dislocation and jam.
  • the pressing force of the loading limit arm 321 received by the elastic limit arm 231 disappears, the elastic limit arm 231 is reset, and with the rotation of the mixing column 210, the elastic limit arm 231 pushes the loading limit arm 321 turns to realize mixing.
  • the loading limit arm 321 is moved several times in small distances, so that the force on the elastic limit arm 231 is gradually reduced, and the amount of deformation is also gradually reduced, so as to avoid the elastic limit arm 231 being directly affected by a large amount.
  • the impact force of the elastic limit arm 231 is extended to achieve the purpose of smoother loading of the reagent, and the life of the elastic limit arm 231 is also extended.

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Abstract

一种试剂混匀和装载装置（10）以及免疫检测设备，其中，试剂混匀和装载装置（10）包括传动机构（100）、混匀机构（200）、装载机构（300）及驱动机构（400），传动机构（100）包括第一转动件（110）及第二转动件（120），第一转动件（110）上可转动连接有多个间隔设置的混匀机构（200），第一转动件（110）能够跟随第二转动件（120）同步转动，驱动机构（400）用于驱动第二转动件（120）转动；混匀机构（200）包括混匀柱（210）、混匀传动件（220）以及混匀限位件（230），混匀传动件（220）套设连接于混匀柱（210）且与第二转动件（120）抵接配合；装载机构（300）包括装载盒（310）及装载配合件（320），装载盒（310）具有供装载盒（310）放置的试剂孔，装载配合件（320）可转动设置于试剂孔内以用于承载装载盒（310）。试剂混匀和装载装置（10）能实现试剂的正常混匀，不会出现卡滞和碰撞等问题。

Description

试剂混匀和装载装置以及免疫检测设备 技术领域
本发明涉及生物检测、诊断领域，特别是涉及一种试剂混匀和装载装置以及免疫检测设备。
背景技术
随着现代科学的发展，免疫诊断技术逐渐成为现代临床检验和科学研究的重点手段。免疫诊断技术是肿瘤、糖尿病、性腺分泌异常等疾病的重要诊断工具。相比传统的检测手段手工操作复杂、反应时间长、具有环境污染性等缺点，免疫诊断技术例如化学发光免疫分析技术具有反应时间短、操作简单以及诊断效率高等优点，并已普遍应用于现代医学和科研领域。
目前，化学发光免疫分析系统主要包括：反应杯存储传送系统、样本装载系统、试剂装载系统、加样系统、孵育系统、离心清洗系统以及发光读数系统。其中试剂装载系统需要在停机状态下手动完成试剂盒的装载和卸载，使得正在运行的测试需要停止，影响测试时间和结果。同时，测试过程中，存在部分试剂被用完的情况，也存在不同的测试项目要用到不同的试剂，此时都需要装载试剂或更换试剂，目前手动装载试剂或更换试剂时均需要停机操作，并且转载易于出现卡滞和碰撞等问题，导致影响正在进行的测试。
发明内容
基于此，有必要提供一种既能实现试剂的正常混匀，又能实现在不停机状态下试剂盒顺利导入而不会出现卡滞和碰撞等问题以提高测试进度的试剂混匀 和装载装置以及免疫检测设备。
一种试剂混匀和装载装置，包括传动机构、混匀机构、装载机构以及驱动机构，所述传动机构包括第一转动件以及第二转动件，所述第一转动件上可转动连接有多个间隔设置的所述混匀机构，所述第一转动件套设于所述第二转动件并能够跟随所述第二转动件同步转动，所述驱动机构与所述第二转动连接以用于驱动所述第二转动件转动；所述混匀机构包括混匀柱、混匀传动件以及混匀限位件，所述混匀传动件套设连接于所述混匀柱且与所述第二转动件抵接配合以实现与所述第二转动件相向转动；所述装载机构包括装载盒以及装载配合件，所述装载盒具有用于供装载盒放置的试剂孔，所述装载配合件可转动设置于所述试剂孔内以用于承载装载盒，所述混匀限位件能够与所述装载配合件配合并推动所述装载配合件转动。
在其中一个实施例中，所述混匀限位件包括至少两个间隔设置的弹性限位臂，所述弹性限位臂连接于所述混匀柱；所述装载配合件具有至少两个间隔设置的装载限位臂，所述装载限位臂至少部分位于所述试剂孔的外部，当所述装载限位臂与所述弹性限位臂错位时，所述装载限位臂与所述弹性限位臂抵接。
在其中一个实施例中，所述装载配合件还包括承载板，所述承载板可转动设置于所述试剂孔内，所述装载限位臂连接于所述承载板并突出于所述试剂孔。
在其中一个实施例中，所述装载限位臂的数量为多个，多个所述装载限位臂在第一圆周上等间隔分布。
在其中一个实施例中，所述弹性限位臂的数量为多个，多个所述弹性限位臂在第二圆周上等间隔分布。
在其中一个实施例中，所述第一圆周的最大直径小于所述第二圆周的最大直径且大于所述第二圆周的最小直径，所述弹性限位臂朝向所述装载限位臂的 一端的内壁具有引导让位面，所述引导让位面呈朝外的坡面状。
在其中一个实施例中，所述第二转动件为齿轮，所述混匀传动件为混匀齿轮，所述第二转动件与所述混匀传动件啮合。
在其中一个实施例中，所述传动机构还包括第一传动轮、传动带以及第二传动轮，所述第一传动轮与所述第二传动轮通过所述传动带连接，所述第二传动轮连接于所述驱动机构的驱动轴，所述第二传动轮通过传动轴连接于所述第二转动件。
在其中一个实施例中，所述装载机构的数量为多个；
所述试剂混匀和装载装置还包括装载转移机构，所述装载转移机构连接于所述装载盒以用于驱动所述装载盒移动。
本发明一实施例还提供了一种免疫检测设备。
一种免疫检测设备，包括所述的试剂混匀和装载装置。
上述的试剂混匀和装载装置既能实现试剂的正常混匀，又能实现在不停机状态下试剂盒顺利导入而不会出现卡滞和碰撞等问题以提高测试进度。
综上所述，上述的试剂混匀和装载装置具有如下有益效果：
(1)、混匀机构结构简单，混匀机构的混匀传动件具有弹性，在实际生产时，可以利用塑胶材料的弹性开模生产，通过塑胶开模即可大批量生产，价格低廉，成本低。
(2)、无需考虑传动误差以及严格限制大齿轮、小齿轮(也即第二转动件、混匀传动件)的传动比，无论装载机构的弹性限位臂和装载限位臂处在何种相对状态下，均可实现装载盒的装载导入，而不会出卡滞和碰撞的情况。
(3)、上述的试剂混匀和装载装置，设置了第一圆周的最大直径小于所述第二圆周的最大直径且大于第二圆周的最小直径，如此，能够保证装载限位臂 在装载时，混匀传动件的进入位置处于弹性限位臂的端面之内，由于弹性限位臂朝向装载限位臂的一端的内壁具有引导让位面，因此，装载限位臂能够沿着引导让位面的坡面逐渐下移以顶开弹性限位臂，随着混匀柱的转动，装载限位臂与弹性限位臂能逐步处于相互错位、卡设的状态，此时，弹性限位臂受到的装载限位臂挤压力消失，弹性限位臂复位，随着混匀柱的转动，弹性限位臂推动装载限位臂转动，实现混匀。
(4)、装载时，通过装载限位臂多次小距离移动的方法，使得弹性限位臂受力逐步较小，变形量也是逐步减小，避免弹性限位臂直接受到较大的冲击力，达到试剂装载更平缓的目的，弹性限位臂的寿命也得到了延长。
(5)、多个装载机构能够提高试剂装载的效率，实现多个试剂盒的装载。例如，在测试过程中，存在部分试剂被用完的情况，也存在不同的测试项目要用到不同的试剂，都需要装载试剂或更换试剂，此时无需停机，可分别通过试剂盒抓取机构进行不同的试剂盒的装载，转载不易于出现卡滞和碰撞等问题，不影响正在进行的测试。
附图说明
图1为本发明一实施例所述的试剂混匀和装载装置示意图；
图2为本发明一实施例所述的装载配合件与混匀限位件正对时示意图；
图3为本发明一实施例所述的装载配合件与混匀限位件完全错位时示意图；
图4为本发明一实施例所述的混匀限位件部分结构示意图。
附图标记说明
10、试剂混匀和装载装置；100、传动机构；110、第一转动件；120、第二转动件；200、混匀机构；210、混匀柱；220、混匀传动件；230、混匀限位件； 231、弹性限位臂；2311、引导让位面；300、装载机构；310、装载盒；320、装载配合件；321、装载限位臂；400、驱动机构。
具体实施方式
为使本发明的上述目的、特征和优点能够更加明显易懂，下面结合附图对本发明的具体实施方式做详细的说明。在下面的描述中阐述了很多具体细节以便于充分理解本发明。但是本发明能够以很多不同于在此描述的其它方式来实施，本领域技术人员可以在不违背本发明内涵的情况下做类似改进，因此本发明不受下面公开的具体实施例的限制。
在本发明的描述中，需要理解的是，术语“中心”、“纵向”、“横向”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”、“内”、“外”、“顺时针”、“逆时针”、“轴向”、“径向”、“周向”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。
此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括至少一个该特征。在本发明的描述中，“多个”的含义是至少两个，例如两个，三个等，除非另有明确具体的限定。
在本发明中，除非另有明确的规定和限定，术语“安装”、“相连”、“连接”、“固定”等术语应做广义理解，例如，可以是固定连接，也可以是可拆卸连接，或成一体；可以是机械连接，也可以是电连接；可以是直接相连，也可以通过中间媒介间接相连，可以是两个元件内部的连通或两个元件的相互作用关系，除 非另有明确的限定。对于本领域的普通技术人员而言，可以根据具体情况理解上述术语在本发明中的具体含义。
在本发明中，除非另有明确的规定和限定，第一特征在第二特征“上”或“下”可以是第一和第二特征直接接触，或第一和第二特征通过中间媒介间接接触。而且，第一特征在第二特征“之上”、“上方”和“上面”可是第一特征在第二特征正上方或斜上方，或仅仅表示第一特征水平高度高于第二特征。第一特征在第二特征“之下”、“下方”和“下面”可以是第一特征在第二特征正下方或斜下方，或仅仅表示第一特征水平高度小于第二特征。
需要说明的是，当元件被称为“固定于”或“设置于”另一个元件，它可以直接在另一个元件上或者也可以存在居中的元件。当一个元件被认为是“连接”另一个元件，它可以是直接连接到另一个元件或者可能同时存在居中元件。本文所使用的术语“垂直的”、“水平的”、“上”、“下”、“左”、“右”以及类似的表述只是为了说明的目的，并不表示是唯一的实施方式。
除非另有定义，本文所使用的所有的技术和科学术语与属于本发明的技术领域的技术人员通常理解的含义相同。本文中在本发明的说明书中所使用的术语只是为了描述具体的实施例的目的，不是旨在于限制本发明。本文所使用的术语“和/或”包括一个或多个相关的所列项目的任意的和所有的组合。
请参阅图1所示，本发明一实施例提供了一种试剂混匀和装载装置10。
一种试剂混匀和装载装置10，包括传动机构100、混匀机构200、装载机构300以及驱动机构400。
传动机构100包括第一转动件110以及第二转动件120。
第一转动件110上可转动连接有多个间隔设置的混匀机构200，多个间隔设置的混匀机构200沿着同一个圆周分布。优选地，第一转动件110设置有多个 沿着圆周分布的容置孔，各个容置孔内均配合有混匀机构200。
第一转动件110套设于第二转动件120并能够跟随第二转动件120同步转动。第二转动件120可以根据需要设置对应的功能。
驱动机构400与第二转动连接以用于驱动第二转动件120转动。
混匀机构200包括混匀柱210、混匀传动件220以及混匀限位件230。混匀柱210可转动设置于容置孔内。混匀传动件220套设连接于混匀柱210且与第二转动件120抵接配合以实现与第二转动件120的相向转动。由于第二转动件120与混匀传动件220是抵接配合的，例如滚动配合、齿轮啮合等配合关系，因此，混匀传动件220能够随着第二转动件120的转动儿相向转动。
混匀机构200的制备材料可以是工程塑料。此时，混匀机构200的重量轻，结构简单，易于开模成型。可理解，在其他实施例中，混匀机构200的准备材料不限于上面，混匀机构200的准备材料还可以是金属材料。
装载机构300包括装载盒310以及装载配合件320。装载盒具有用于供装载盒310放置的试剂孔。装载配合件320可转动设置于试剂孔内以用于承载装载盒310，混匀限位件230能够与装载配合件320配合并推动装载配合件320转动。具体地，装载装载盒310时，通过装载盒310抓取机构抓取装载盒310至混匀机构200位置处，混匀限位件230能够与装载配合件320配合，例如相互抵接，当混匀限位件230随着混匀柱210转动时，混匀限位件230能够推动混匀限位件230转动，混匀限位件230的转动能够带动装载配合件320及其承载的装载盒310转动，实现试剂的混匀。
请参阅图2所示，在其中一些实施例中，混匀限位件230包括至少两个间隔设置的弹性限位臂231。弹性限位臂231连接于混匀柱210。装载配合件320具有至少两个间隔设置的装载限位臂321。装载限位臂321至少部分位于试剂孔 的外部。当装载限位臂321与弹性限位臂231错位时，装载限位臂321与弹性限位臂231抵接。具体地，在装载时，通过装载盒310抓取机构抓取装载盒310至混匀机构200位置处，此时，装载限位臂321不一定直接能与弹性限位臂231达到完全错位的位置，但不影响继续装载，由于弹性限位臂231具有弹性，因此，当装载限位臂321下移时与弹性限位臂231正好抵接(装载限位臂321与弹性限位臂231完全正对，请参阅图2所示)，装载限位臂321能够挤压、逐步撑开弹性限位臂231，随着混匀柱210转动，装载限位臂321逐步与弹性限位臂231错位，直至装载限位臂321与弹性限位臂231完全错位(请参阅图3所示)，此时，弹性限位臂231复位，在径向方向上，载限位臂与弹性限位臂231能抵接配合产生干涉，装载限位臂321可随着弹性限位臂231的转动而转动，装载限位臂321的转动能够带动其承载的装载盒310转动，实现试剂的混匀。
在其中一些实施例中，装载配合件320还包括承载板。承载板可转动设置于试剂孔内，装载限位臂321连接于承载板并突出于试剂孔。例如，试剂孔沿着装载盒310的竖直方向设置，承载板转动设置于试剂孔内，承载板靠近于试剂孔的底部位置，装载限位臂321的一端连接于承载板的底面，装载限位臂321的另一端朝试剂孔的外部延伸。
在其中一些实施例中，请参阅图2所示，装载限位臂321的数量为多个。多个装载限位臂321在第一圆周上等间隔分布。
在其中一些实施例中，请参阅图2所示，弹性限位臂231的数量为多个。多个弹性限位臂231在第二圆周上等间隔分布。
在其中一些实施例中，由于装载限位臂321具有一定的厚度，弹性限位臂231也具有一定的厚度，因此，装载限位臂321所在的第一圆周呈环形形状，弹性限位臂231所在的第二圆周也呈环形形状。第一圆周的最大直径小于第二圆 周的最大直径且大于第二圆周的最小直径。请参阅图4所示，弹性限位臂231朝向装载限位臂321的一端的内壁具有引导让位面2311，引导让位面2311呈朝外的坡面状。如此设置，能够保证装载限位臂321由弹性限位臂231的正上方下降，当装载限位臂321与弹性限位臂231处于非完全错位状态时(请参阅图2所示)，装载限位臂321会缓慢接触到弹性限位臂231，装载限位臂321沿着引导让位面2311下降，并逐步挤压弹性限位臂231张开，随着混匀柱210转动，装载限位臂321逐步与弹性限位臂231错位，直至装载限位臂321与弹性限位臂231完全错位(请参阅图3所示)。
在其中一些实施例中，第二转动件120为齿轮，混匀传动件220为混匀齿轮，第二转动件120与混匀传动件220啮合。第二转动件120与混匀传动件220通过啮合配合，能够提高传动稳定性。
在其中一些实施例中，传动机构100还包括第一传动轮、传动带以及第二传动轮。第一传动轮、传动带以及第二传动轮在附图中未示出。第一传动轮与第二传动轮通过传动带连接，第二传动轮连接于驱动机构400的驱动轴，第二传动轮通过传动轴连接于第二转动件120。
在其中一些实施例中，装载机构300的数量为多个。多个装载机构300能够提高试剂装载的效率，实现多个试剂盒的装载。例如，在测试过程中，存在部分试剂被用完的情况，也存在不同的测试项目要用到不同的试剂，都需要装载试剂或更换试剂，此时无需停机，可分别通过试剂盒抓取机构进行不同的试剂盒的装载，转载不易于出现卡滞和碰撞等问题，不影响正在进行的测试。
在其中一些实施例中，试剂混匀和装载装置10还包括装载转移机构，装载转移机构连接于装载盒310以用于驱动装载盒310移动。
上述的试剂混匀和装载装置10既能实现试剂的正常混匀，又能实现在不停 机状态下试剂盒顺利导入而不会出现卡滞和碰撞等问题以提高测试进度。
本发明一实施例还提供了一种免疫检测设备。
一种免疫检测设备，包括的试剂混匀和装载装置10。
综上，上述的试剂混匀和装载装置10具有如下有益效果：
(1)、混匀机构200结构简单，混匀机构200的混匀传动件220具有弹性，在实际生产时，可以利用塑胶材料的弹性开模生产，通过塑胶开模即可大批量生产，价格低廉，成本低。
(2)、无需考虑传动误差以及严格限制大齿轮、小齿轮(也即第二转动件120、混匀传动件220)的传动比，无论装载机构300的弹性限位臂231和装载限位臂321处在何种相对状态下，均可实现装载盒310的装载导入，而不会出卡滞和碰撞的情况。
(3)、上述的试剂混匀和装载装置10，设置了第一圆周的最大直径小于第二圆周的最大直径且大于第二圆周的最小直径，如此，能够保证装载限位臂321在装载时，混匀传动件220的进入位置处于弹性限位臂231的端面之内，由于弹性限位臂231朝向装载限位臂321的一端的内壁具有引导让位面2311，因此，装载限位臂321能够沿着引导让位面2311的坡面逐渐下移以顶开弹性限位臂231，随着混匀柱210的转动，装载限位臂321与弹性限位臂231能逐步处于相互错位、卡设的状态，此时，弹性限位臂231受到的装载限位臂321挤压力消失，弹性限位臂231复位，随着混匀柱210的转动，弹性限位臂231推动装载限位臂321转动，实现混匀。
(4)、装载时，通过装载限位臂321多次小距离移动的方法，使得弹性限位臂231受力逐步较小，变形量也是逐步减小，避免弹性限位臂231直接受到较大的冲击力，达到试剂装载更平缓的目的，弹性限位臂231的寿命也得到了 延长。
以上所述实施例的各技术特征可以进行任意的组合，为使描述简洁，未对上述实施例中的各个技术特征所有可能的组合都进行描述，然而，只要这些技术特征的组合不存在矛盾，都应当认为是本说明书记载的范围。
以上所述实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对本发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。因此，本发明专利的保护范围应以所附权利要求为准。

Claims (10)

  1. 一种试剂混匀和装载装置，其特征在于，包括传动机构、混匀机构、装载机构以及驱动机构，所述传动机构包括第一转动件以及第二转动件，所述第一转动件上可转动连接有多个间隔设置的所述混匀机构，所述第一转动件套设于所述第二转动件并能够跟随所述第二转动件同步转动，所述驱动机构与所述第二转动连接以用于驱动所述第二转动件转动；所述混匀机构包括混匀柱、混匀传动件以及混匀限位件，所述混匀传动件套设连接于所述混匀柱且与所述第二转动件抵接配合以实现与所述第二转动件相向转动；所述装载机构包括装载盒以及装载配合件，所述装载盒具有用于供所述装载盒放置的试剂孔，所述装载配合件可转动设置于所述试剂孔内以用于承载所述装载盒，所述混匀限位件能够与所述装载配合件配合并推动所述装载配合件转动。
  2. 根据权利要求1所述的试剂混匀和装载装置，其特征在于，所述混匀限位件包括至少两个间隔设置的弹性限位臂，所述弹性限位臂连接于所述混匀柱；所述装载配合件具有至少两个间隔设置的装载限位臂，所述装载限位臂至少部分位于所述试剂孔的外部，当所述装载限位臂与所述弹性限位臂错位时，所述装载限位臂与所述弹性限位臂抵接。
  3. 根据权利要求2所述的试剂混匀和装载装置，其特征在于，所述装载配合件还包括承载板，所述承载板可转动设置于所述试剂孔内，所述装载限位臂连接于所述承载板并突出于所述试剂孔。
  4. 根据权利要求3所述的试剂混匀和装载装置，其特征在于，所述装载限位臂的数量为多个，多个所述装载限位臂在第一圆周上等间隔分布。
  5. 根据权利要求4所述的试剂混匀和装载装置，其特征在于，所述弹性限位臂的数量为多个，多个所述弹性限位臂在第二圆周上等间隔分布。
  6. 根据权利要求5所述的试剂混匀和装载装置，其特征在于，所述第一圆周 的最大直径小于所述第二圆周的最大直径且大于所述第二圆周的最小直径，所述弹性限位臂朝向所述装载限位臂的一端的内壁具有引导让位面，所述引导让位面呈朝外的坡面状。
  7. 根据权利要求1-6任意一项所述的试剂混匀和装载装置，其特征在于，所述第二转动件为齿轮，所述混匀传动件为混匀齿轮，所述第二转动件与所述混匀传动件啮合。
  8. 根据权利要求1-6任意一项所述的试剂混匀和装载装置，其特征在于，所述传动机构还包括第一传动轮、传动带以及第二传动轮，所述第一传动轮与所述第二传动轮通过所述传动带连接，所述第二传动轮连接于所述驱动机构的驱动轴，所述第二传动轮通过传动轴连接于所述第二转动件。
  9. 根据权利要求1-6任意一项所述的试剂混匀和装载装置，其特征在于，所述装载机构的数量为多个；
    所述试剂混匀和装载装置还包括装载转移机构，所述装载转移机构连接于所述装载盒以用于驱动所述装载盒移动。
  10. 一种免疫检测设备，其特征在于，包括权利要求1-9任意一项所述的试剂混匀和装载装置。
PCT/CN2022/072672 2021-04-28 2022-01-19 试剂混匀和装载装置以及免疫检测设备 WO2022227724A1 (zh)

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