WO2021120759A1 - 一种全自动化学发光免疫分析仪 - Google Patents

一种全自动化学发光免疫分析仪 Download PDF

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WO2021120759A1
WO2021120759A1 PCT/CN2020/117130 CN2020117130W WO2021120759A1 WO 2021120759 A1 WO2021120759 A1 WO 2021120759A1 CN 2020117130 W CN2020117130 W CN 2020117130W WO 2021120759 A1 WO2021120759 A1 WO 2021120759A1
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mixing
axis
mechanical arm
module
wheel
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PCT/CN2020/117130
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English (en)
French (fr)
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靳明
高燕
刘振世
王俊杰
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江苏泽成生物技术有限公司
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Priority to US17/086,491 priority Critical patent/US20210080477A1/en
Publication of WO2021120759A1 publication Critical patent/WO2021120759A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G01N21/763—Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N2035/00891—Displaying information to the operator

Definitions

  • the invention relates to the field of luminescence analysis equipment, in particular to an automatic chemiluminescence immunoassay analyzer.
  • Chemiluminescence immunoassay is a clinical medical test technique used for the detection of antigens or antibodies in human body fluids. Because of its high sensitivity, good selectivity and other advantages, it has been widely used. At present, it has become a common method in clinical immunological testing from theoretical research in the laboratory. Correspondingly, the development of various chemiluminescence immunoassay instruments has become more and more mature.
  • Chemiluminescence amplification technology uses the principle of antigen-antibody reaction to label enzymes or other non-radioactive markers on antigens or antibodies, and then react with known antigens or antibodies. The labeled enzyme makes the reaction substrate emit light, which is measured by a photon counter.
  • the luminescence count per second of the tested sample can be obtained, and then the luminescence count is converted into the concentration value of the sample according to the built-in standard curve. Due to the application of this technology, the antigen-antibody reaction time is shortened, and the degree of specificity and sensitivity are improved, making it possible to realize the full automation of the entire reaction.
  • our company has previously developed an automatic chemiluminescence immunoassay analyzer.
  • the specific content can be seen in the publication number CN103743916A, and the invention title is: an invention patent for an automatic chemiluminescence immunoassay analyzer.
  • our company has further optimized it to make It is more stable, with higher test throughput, lower cost, simple installation, and good stability, which can make the sample, reagent and magnetic particles react more fully.
  • the invention provides an automatic chemiluminescence immunoassay analyzer, which solves the problem that the existing analyzer needs to be further optimized.
  • An automatic chemiluminescence immunoassay analyzer including a reaction tube module, a sample tube module, a reagent box module, a three-dimensional mechanical arm module, a test tube grabbing device, a mixing structure, an incubation chamber, a cleaning device, an electronic control part and a PC control terminal Composition;
  • the three-dimensional mechanical arm module includes an X-axis mechanical arm, a Y-axis mechanical arm and a Z-axis mechanical arm, the bottom of the Z-axis mechanical arm is provided with a sampling needle;
  • a test tube grabbing device is installed beside the reaction tube module;
  • the mixing structure includes a mixing motor, a first mixing wheel is installed at the power output end of the mixing motor, a second mixing wheel is installed on the first mixing wheel, and the first mixing wheel It is connected to the second mixing wheel through a bearing, the second mixing wheel is of a hollow structure, and one side of the second mixing wheel is provided with an "inverted U-shaped" mixing baffle.
  • a mixing gear lever is
  • the three-dimensional mechanical arm module includes an X-axis mechanical arm, a Y-axis mechanical arm, and a Z-axis mechanical arm.
  • the X-axis mechanical arm includes a mounting platform on which a wide linear guide rail is provided.
  • the axis mechanical arm is slidably mounted on the wide linear guide through the X-axis bottom plate, the Z-axis mechanical arm is movably installed on the Y-axis mechanical arm through the Y-axis transmission belt, and the X-axis is installed on the mounting platform along the X axis.
  • the X-axis driving wheel and the X-axis driven wheel are connected to the power output end of the X-axis motor, the X-axis driving wheel and the X-axis driven wheel are sleeved with an X-axis belt, and the X-axis bottom plate is connected to the X axis.
  • the shaft belt is fixed.
  • the inner wall of the hollow structure of the second mixing wheel is provided with a non-slip layer.
  • the outer covers of the Y-axis robot arm and the Z-axis robot arm of the three-dimensional robot arm module are provided with dust covers.
  • test tube grabbing device is installed in the mounting shell.
  • the reaction tube module, the sample tube module, the reagent box module, the three-dimensional mechanical arm module, the test tube grabbing device, the mixing structure, the incubation chamber and the cleaning device are installed in a transparent rack.
  • the present invention uses a test tube grabbing device to replace the original picking and placing tube device, which reduces the cost and improves the stability of the mobile reaction tube.
  • the syringe pump pipette structure used before is similar to the pipette gun. Put the reaction tube, but occasionally it may not be able to open the reaction tube.
  • the improved test tube grab device has two grippers to hold the reaction tube. When the gripper is opened, the reaction tube is lowered, which reduces the cost, is simple to install, and is stable. Good; the present invention adds a mixing structure to the original model, which can make the samples, reagents and magnetic particles more fully react and reduce the carry-over contamination rate.
  • Figure 1 is a schematic diagram of the structure of the present invention
  • Fig. 2 is a schematic structural view of one direction of the three-dimensional mechanical arm module of the present invention.
  • FIG. 3 is a schematic structural diagram of the three-dimensional mechanical arm module of the present invention in another direction;
  • Figure 4 is a schematic structural diagram of the mixing structure of the present invention.
  • Fig. 5 is a main cross-sectional view of the mixing structure of the present invention.
  • 1-dimensional mechanical arm module 1-1-mounting platform, 1-2-wide linear guide rail, 1-3-X-axis bottom plate, 1-4-Z-axis mechanical arm, 1-5-Y-axis transmission belt , 1-6-X axis driving wheel, 1-7-X axis driven wheel, 1-8-X axis motor, 1-9-X axis belt, 1-10-dust cover, 2-tube grabbing device , 3-mixing structure, 3-1-mixing motor, 3-2-first mixing wheel, 3-3-second mixing wheel, 3-4-bearing, 3-5-mixing baffle, 3-6-mixing lever, 4-sample tube module, 5-reagent box module, 6-reaction tube module, 7-incubation chamber, 8-sample needle, 9-washing device, 10-PC control terminal, 11-transparent frame.
  • an automatic chemiluminescence immunoassay analyzer includes a reaction tube module 6, a sample tube module 4, a reagent box module 5, a three-dimensional robotic arm module 1, a test tube grabbing device 2, and a mixing structure 3.
  • the incubation chamber 7, the cleaning device 9, the electronic control part and the PC control terminal 10 are composed;
  • the three-dimensional mechanical arm module 1 includes the X-axis mechanical arm, the Y-axis mechanical arm and the Z-axis mechanical arm 1-4, and the Z-axis mechanical arm 1-4
  • a sampling needle 8 is provided at the bottom.
  • the reaction tube module A test tube grabbing device 2 is installed beside 6.
  • the specific structure of the test tube grabbing device 2 can be found in our company’s application publication number CN207373198U.
  • the patent name is: an invention patent for a test tube grabbing device; mixing structure 3 It includes a mixing motor 3-1.
  • the power output end of the mixing motor 3-1 is equipped with a first mixing wheel 3-2, and the first mixing wheel 3-2 is equipped with a second mixing wheel 3-3.
  • the first mixing wheel 3-2 and the second mixing wheel 3-3 are connected by a bearing 3-4, and the second mixing wheel 3-3 has a hollow structure, which is convenient for putting the reaction tube into the second mixing wheel 3- Mixing in 3,
  • the second mixing wheel 3-3 is provided with an "inverted U-shaped" mixing baffle 3-5 on one side, and the outer wall of the second mixing wheel 3-3 is fixed with a mixing lever 3-6, The mixing lever 3-6 extends into the mixing baffle 3-5.
  • the sample tube module 4 When in use, the sample tube module 4, the reagent box module 5 and the reaction tube module 6 are used to store samples, reagents and reaction tubes respectively.
  • the three-dimensional robotic arm module 1 drives the sampling needle 8 to separate the sample tube module 4 and the reagents.
  • the samples, reagents and magnetic particles in the box module 5 are sampled and added to the reaction tube of the reaction tube module 6.
  • the test tube grabbing device 2 will take the liquid-filled reaction tube into the mixing structure 3 for mixing and mixing.
  • the rotation of the motor 3-1 drives the first mixing wheel 3-2 fixed on the shaft end of the motor to rotate together, and the first mixing wheel 3-2 in turn drives the second mixing wheel 3-3 together with the second mixing wheel 3-3.
  • the reaction tube rotates, because the second mixing wheel 3-3 and the first mixing wheel 3-2 are connected by a bearing connection, when the second mixing wheel 3-3 rotates, the second mixing wheel 3
  • the mixing lever 3-6 on -3 will be blocked by the mixing baffle 3-5.
  • the second mixing wheel 3-3 will oscillate between the mixing baffle 3-5, so that The samples, reagents and magnetic particles in the reaction tube are fully mixed; after mixing, take the test tube gripper device 2 and put the reaction tube into the incubation chamber 7 for reaction incubation. After the reaction is complete, take the test tube gripper device 2 and grab the reaction tube to The cleaning test is performed in the cleaning device 9, and the test result will be displayed on the PC control terminal 10.
  • the present invention uses the test tube grabbing device 2 to replace the original taking and placing tube device, which reduces the cost and improves the stability of the mobile reaction tube.
  • the previously used syringe pump pipette structure is similar to a pipette to take and place the reaction tube.
  • the improved test tube grabbing device 2 has two grabbing pieces to hug the reaction tube. When the grabbing piece is opened, the reaction tube is put down, which reduces the cost, is simple to install, and has good stability;
  • the invention adds a mixing structure 3 to the original model, which can make the sample, reagent and magnetic particles react more fully and reduce the carry-over contamination rate.
  • the three-dimensional robotic arm module 1 includes an X-axis robotic arm, a Y-axis robotic arm, and a Z-axis robotic arm 1-4.
  • the X-axis robotic arm includes a mounting platform 1-1, and a wide linear guide rail is provided on the mounting platform 1-1.
  • the Y-axis robot arm is slidably mounted on the wide linear guide 1-2 through the X-axis bottom plate 1-3
  • the Z-axis robot arm 1-4 is movably installed on the Y-axis robot arm through the Y-axis transmission belt 1-5
  • X-axis driving wheels 1-6 and X-axis driven wheels 1-7 are installed along the X axis.
  • the X-axis driving wheels 1-6 are connected to the power output end of the X-axis motor 1-8.
  • Axis driving wheels 1-6 and X-axis driven wheels 1-7 are fitted with X-axis belts 1-9, X-axis bottom plate 1-3 and X-axis belts 1-9 are fixed, driven by X-axis motor 1-8 It can drive the X-axis belt 1-9 to move between the X-axis driving wheel 1-6 and the X-axis driven wheel 1-7, and then drive the Y-axis mechanical arm on the X-axis bottom plate 1-3 to move in the X-axis direction; Optimize the two cylindrical guide rails of the original X-axis robotic arm into a single wide linear guide 1-2, which has low installation requirements.
  • the installation requirements of the two cylindrical guide rails of the original X-axis robotic arm are stricter, and it is necessary to ensure that the two cylindrical guide rails are opposite. Parallel, otherwise it will affect the smooth motion of the manipulator, and it is prone to jams.
  • the optimized X-axis manipulator has improved stability and relatively reduced noise, which can run more stably and efficiently; the present invention uses the original X-axis manipulator to operate more stably and efficiently.
  • the two cylindrical guide rails are optimized as a single wide linear guide rail 1-2, which has low installation requirements.
  • the installation requirements of the two cylindrical guide rails of the original X-axis robotic arm are stricter.
  • the optimized X-axis mechanical arm has improved stability and relatively reduced noise, which can operate more stably and efficiently.
  • the inner wall of the hollow structure of the second mixing wheel 3-3 is provided with a non-slip layer.
  • rubber and other materials can be used to ensure an effective anti-skid effect. It can prevent the reaction tube from being thrown out during the shaking process.
  • the outer cover of the Y-axis mechanical arm and the Z-axis mechanical arm 1-4 of the three-dimensional mechanical arm module 1 is provided with a dust cover 1-10.
  • test tube grabbing device 2 In order to prevent the test tube grabbing device 2 from being stuck or contaminated during use, the test tube grabbing device 2 is installed in the mounting shell, which not only prolongs the service life of the test tube grabbing device 2 but also enhances its aesthetics.
  • the cleaning device 9 is installed in the transparent frame 11, which can facilitate the staff to monitor the internal working conditions during the reaction process, and can increase the service life of the present invention, and the transparent frame 11 is provided with a window for easy opening operation.

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Abstract

一种全自动化学发光免疫分析仪，涉及发光分析设备领域，包括反应管模块(6)，样品管模块(4)，试剂盒模块(5)，三维机械臂模块(1)，取试管抓手装置(2)，混匀结构(3)，温育仓(7)，清洗装置(9)以及电控部分和PC控制端(10)组成；三维机械臂模块(1)包括X轴机械臂、Y轴机械臂和Z轴机械臂(1-4)，Z轴机械臂(1-4)底部设有取样针(8)；反应管模块(6)旁安装有取试管抓手装置(2)；混匀结构(3)包括混匀电机(3-1)，混匀电机(3-1)的动力输出端安装有第一混匀轮(3-2)，第一混匀轮(3-2)上安装有第二混匀轮(3-3)，第一混匀轮(3-2)和第二混匀轮(3-3)之间通过轴承(3-4)连接，第二混匀轮(3-3)为中空结构，第二混匀轮(3-3)一侧设有"倒U型"混匀挡片(3-5)，第二混匀轮(3-3)外壁固定有混匀档杆(3-6)，混匀档杆(3-6)伸入混匀挡片(3-5)内。

Description

一种全自动化学发光免疫分析仪 技术领域
本发明涉及发光分析设备领域，特别涉及一种全自动化学发光免疫分析仪。
背景技术
化学发光免疫分析是用于人体体液中的抗原或抗体检测的临床医学检验技术。由于其灵敏度高、选择性好等优点而受到广泛应用，目前已从实验室的理论研究成为临床免疫学检验中的常用手段。相应地，对各种化学发光免疫分析仪器的研制也越来越成熟。化学发光放大技术是利用抗原—抗体反应原理，将酶或其他非放射性标记物标记于抗原或抗体，然后与已知抗原或抗体反应，标记的酶使反应底物进行发光，经光子计数器测量后可得到被测样本的每秒种发光计数，再根据内置的标准曲线将发光计数转换成样本的浓度值。由于这项技术的应用，使抗原—抗体的反应时间缩短，特异性程度和灵敏度得到提高，使整个反应的全自动化实现成为可能。
我司之前研发了一款全自动化学发光免疫分析仪，具体内容可见公开号为CN103743916A，发明名称为：一种全自动化学发光免疫分析仪的发明专利，在此基础上我司进一步优化，使其更加稳定，测试通量更高，成本降低，安装简单，稳定性好，能够使样本、试剂及磁微粒反应更加充分。
发明内容
本发明提供一种全自动化学发光免疫分析仪，解决现有的分析仪还有待进一步优化的问题。
为了解决上述技术问题，本发明的技术方案为：
一种全自动化学发光免疫分析仪，包括反应管模块，样品管模块，试剂盒模块，三维机械臂模块，取试管抓手装置，混匀结构，温育仓，清洗装置以及电控部分和PC控制端组成；所述三维机械臂模块包括X轴机械臂、Y轴机械臂和Z轴机械臂，所述Z轴机械臂底部设有取样针；所述反应管模块旁安装有取试管抓手装置；所述混匀结构包括混匀电机，所述混匀电机的动力输出端安装有第一混匀轮，所述第一混匀轮上安装有第二混匀轮，所述第一混匀轮和第二混匀轮之间通过轴承连接，所述第二混匀轮为中空结构，所述第二混匀轮一侧设有“倒U型”混匀挡片，所述第二混匀轮外壁固定有混匀档杆，所述混匀档杆伸入混匀挡片内。
优选的，所述三维机械臂模块包括X轴机械臂、Y轴机械臂和Z轴机械臂，所述X轴机械臂包括安装平台，所述安装平台上设有宽型直线导轨，所述Y轴机械臂通过X轴底板滑动安装在所述宽型直线导轨上，所述Z轴机械臂通过Y轴传动带可移动地安装在Y轴机械臂上，所述安装平台上沿X轴安装有X轴主动轮和X轴从动轮，所述X轴主动轮与X轴电机的动力输出端相连，所述X轴主动轮和X轴从动轮上套装有X轴皮带，所述X轴底板与X轴皮带相固定。
优选的，所述第二混匀轮中空的结构内壁设有防滑层。
优选的，所述三维机械臂模块的Y轴机械臂和Z轴机械臂外罩设有防尘罩。
优选的，所述取试管抓手装置安装在安装壳内。
优选的，所述反应管模块，样品管模块，试剂盒模块，三维机械臂模块，取试管抓手装置，混匀结构，温育仓和清洗装置安装在透明机架内。
采用上述技术方案，本发明采用取试管抓手装置取代原先的取放管装置，降低了成本，提高了移动反应管的稳定性，之前使用的注射泵式移管结构，类似移液枪的方式取放反应管，但是偶尔出现打不下反应管的情况，改进后的取试管抓手装置有两个抓手片将反应管抱住，抓手片张开时放下反应管，成本降低，安装简单，稳定性好；本发明在原有的机型上增加了混匀结构，能够使样本、试剂及磁微粒反应更加充分，降低了携带污染率。
附图说明
图1为本发明的结构示意图；
图2为本发明的三维机械臂模块的一个方向的结构示意图；
图3为本发明的三维机械臂模块的另一个方向的结构示意图；
图4为本发明的混匀结构的结构示意图；
图5为本发明的混匀结构的主剖视图。
图中，1-三维机械臂模块，1-1-安装平台，1-2-宽型直线导轨，1-3-X轴底板，1-4-Z轴机械臂，1-5-Y轴传动带，1-6-X轴主动轮，1-7-X轴从动轮，1-8-X轴电机，1-9-X轴皮带，1-10-防尘罩，2-取试管抓手装置，3-混匀结构，3-1-混匀电机，3-2-第一混匀轮，3-3-第二混匀轮，3-4-轴承，3-5-混匀挡片，3-6-混匀档杆，4-样品管模块，5-试剂盒模块，6-反应管模块，7-温育仓，8-取样针，9-清洗装置，10-PC控制端，11-透明机架。
具体实施方式
下面结合附图对本发明的具体实施方式作进一步说明。在此需要说明的是，对于这些实 施方式的说明用于帮助理解本发明，但并不构成对本发明的限定。此外，下面所描述的本发明各个实施方式中所涉及的技术特征只要彼此之间未构成冲突就可以相互组合。
在本发明的描述中，需要理解的是，术语“中心”、“纵向”、“横向”、“长度”、“宽度”、“厚度”、“上”、“下”、“前”、“后”、“左”、“右”、“竖直”、“水平”、“顶”、“底”“内”、“外”、“顺时针”、“逆时针”、“轴向”、“径向”、“周向”等指示的方位或位置关系为基于附图所示的方位或位置关系，仅是为了便于描述本发明和简化描述，而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作，因此不能理解为对本发明的限制。
如图1-5所示，一种全自动化学发光免疫分析仪，包括反应管模块6，样品管模块4，试剂盒模块5，三维机械臂模块1，取试管抓手装置2，混匀结构3，温育仓7，清洗装置9以及电控部分和PC控制端10组成；三维机械臂模块1包括X轴机械臂、Y轴机械臂和Z轴机械臂1-4，Z轴机械臂1-4底部设有取样针8，在三维机械臂模块1的带动下能够分别将样品管模块4和试剂盒模块5内的样品、试剂和磁微粒取样添加到反应管模块6的反应管内，反应管模块6旁安装有取试管抓手装置2，具体取试管抓手装置2的结构可参见本司申请的公开号为CN207373198U，专利名称为：一种取试管抓手装置的发明专利；混匀结构3包括混匀电机3-1，混匀电机3-1的动力输出端安装有第一混匀轮3-2，第一混匀轮3-2上安装有第二混匀轮3-3，第一混匀轮3-2和第二混匀轮3-3之间通过轴承3-4连接，第二混匀轮3-3为中空结构，便于将反应管放入第二混匀轮3-3内进行混匀，第二混匀轮3-3一侧设有“倒U型”混匀挡片3-5，第二混匀轮3-3外壁固定有混匀档杆3-6，混匀档杆3-6伸入混匀挡片3-5内。
使用时，样品管模块4，试剂盒模块5和反应管模块6分别用于存放样品、试剂和反应管，当实验开始后，三维机械臂模块1带动取样针8分别将样品管模块4和试剂盒模块5内的样品、试剂和磁微粒取样添加到反应管模块6的反应管内，取试管抓手装置2会把加好液体的反应管取放到混匀结构3里进行混匀，混匀电机3-1旋转带动固定在电机轴端的第一混匀轮3-2一起旋转，第一混匀轮3-2进而带动第二混匀轮3-3连同第二混匀轮3-3内的反应管转动，由于第二混匀轮3-3与第一混匀轮3-2的连接是靠轴承的连接方式，当第二混匀轮3-3旋转时，第二混匀轮3-3上的混匀档杆3-6会被混匀挡片3-5所阻挡，这时第二混匀轮3-3就会在混匀挡片3-5之间形成振荡，从而使反应管内的样本、试剂及磁微粒混匀充分；混匀后，取试管抓手装置2将反应管放入温育仓7内反应温育，反应好后取试管抓手装置2将反应管抓取到清洗装置9内清洗检测，检测结果会在PC控制端10显示出来。
本发明采用取试管抓手装置2取代原先的取放管装置，降低了成本，提高了移动反应管 的稳定性，之前使用的注射泵式移管结构，类似移液枪的方式取放反应管，但是偶尔出现打不下反应管的情况，改进后的取试管抓手装置2有两个抓手片将反应管抱住，抓手片张开时放下反应管，成本降低，安装简单，稳定性好；本发明在原有的机型上增加了混匀结构3，能够使样本、试剂及磁微粒反应更加充分，降低了携带污染率。
具体的，三维机械臂模块1包括X轴机械臂、Y轴机械臂和Z轴机械臂1-4，X轴机械臂包括安装平台1-1，安装平台1-1上设有宽型直线导轨1-2，Y轴机械臂通过X轴底板1-3滑动安装在宽型直线导轨1-2上，Z轴机械臂1-4通过Y轴传动带1-5可移动地安装在Y轴机械臂上，安装平台1-1上沿X轴安装有X轴主动轮1-6和X轴从动轮1-7，X轴主动轮1-6与X轴电机1-8的动力输出端相连，X轴主动轮1-6和X轴从动轮1-7上套装有X轴皮带1-9，X轴底板1-3与X轴皮带1-9相固定，在X轴电机1-8的带动下能够带动X轴皮带1-9沿着X轴主动轮1-6和X轴从动轮1-7之间移动，进而带动X轴底板1-3上的Y轴机械臂沿X轴方向移动；通过将原X轴机械臂的两个圆柱导轨优化为单个宽型直线导轨1-2，安装要求低，原X轴机械臂的两个圆柱导轨的安装要求较严格，需保证两个圆柱导轨要相对平行，否则会影响机械臂的顺畅运动，容易出现卡顿现象，优化后的X轴机械臂稳定性提高，噪声也相对降低，能更稳定高效的运行；本发明通过将原X轴机械臂的两个圆柱导轨优化为单个宽型直线导轨1-2，安装要求低，原X轴机械臂的两个圆柱导轨的安装要求较严格，需保证两个圆柱导轨要相对平行，否则会影响机械臂的顺畅运动，容易出现卡顿现象，优化后的X轴机械臂稳定性提高，噪声也相对降低，能更稳定高效的运行。
为了保证反应管加入第二混匀轮3-3内震荡的稳定性，第二混匀轮3-3中空的结构内壁设有防滑层，具体可使用橡胶等材质，能够保证有效的防滑效果，能够防止反应管在震荡的过程中被甩出。
为了增强本发明的使用寿命和美观性，三维机械臂模块1的Y轴机械臂和Z轴机械臂1-4外罩设有防尘罩1-10。
为了防止取试管抓手装置2在使用过程中发生卡顿或污染等情况，取试管抓手装置2安装在安装壳内，不仅能够延长取试管抓手装置2的使用寿命且能够增强美观性。
为了提升本发明的使用的可监测性和稳定性，反应管模块6，样品管模块4，试剂盒模块5，三维机械臂模块1，取试管抓手装置2，混匀结构3，温育仓7和清洗装置9安装在透明机架11内，能够在反应的过程中便于工作人员对内部工作情况进行监控，且能够提升本发明的使用寿命，且透明机架11上开设有视窗，便于打开操作。
以上所述，仅是本发明的较佳实施例而已，并非对本发明作任何形式上的限制，虽然本发明已以较佳实施例揭露如上，然而并非用以限定本发明,任何熟悉本专业的技术人员，在不 脱离本发明技术方案范围内,当可利用上述揭示的技术内容作出些许更动或修饰为等同变化的等效实施例,但凡是未脱离本发明技术方案的内容，依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与修饰，均仍属于本发明技术方案的范围内。

Claims (6)

  1. 一种全自动化学发光免疫分析仪，其特征在于：包括反应管模块(6)，样品管模块(4)，试剂盒模块(5)，三维机械臂模块(1)，取试管抓手装置(2)，混匀结构(3)，温育仓(7)，清洗装置(9)以及电控部分和PC控制端(10)组成；所述三维机械臂模块(1)包括X轴机械臂、Y轴机械臂和Z轴机械臂(1-4)，所述Z轴机械臂(1-4)底部设有取样针(8)；所述反应管模块(6)旁安装有取试管抓手装置(2)；所述混匀结构(3)包括混匀电机(3-1)，所述混匀电机(3-1)的动力输出端安装有第一混匀轮(3-2)，所述第一混匀轮(3-2)上安装有第二混匀轮(3-3)，所述第一混匀轮(3-2)和第二混匀轮(3-3)之间通过轴承(3-4)连接，所述第二混匀轮(3-3)为中空结构，所述第二混匀轮(3-3)一侧设有“倒U型”混匀挡片(3-5)，所述第二混匀轮(3-3)外壁固定有混匀档杆(3-6)，所述混匀档杆(3-6)伸入混匀挡片(3-5)内。
  2. 根据权利要求1所述的全自动化学发光免疫分析仪，其特征在于：所述三维机械臂模块(1)包括X轴机械臂、Y轴机械臂和Z轴机械臂(1-4)，所述X轴机械臂包括安装平台(1-1)，所述安装平台(1-1)上设有宽型直线导轨(1-2)，所述Y轴机械臂通过X轴底板(1-3)滑动安装在所述宽型直线导轨(1-2)上，所述Z轴机械臂(1-4)通过Y轴传动带(1-5)可移动地安装在Y轴机械臂上，所述安装平台(1-1)上沿X轴安装有X轴主动轮(1-6)和X轴从动轮(1-7)，所述X轴主动轮(1-6)与X轴电机(1-8)的动力输出端相连，所述X轴主动轮(1-6)和X轴从动轮(1-7)上套装有X轴皮带(1-9)，所述X轴底板(1-3)与X轴皮带(1-9)相固定。
  3. 根据权利要求1所述的全自动化学发光免疫分析仪，其特征在于：所述第二混匀轮(3-3)中空的结构内壁设有防滑层。
  4. 根据权利要求1所述的全自动化学发光免疫分析仪，其特征在于：所述三维机械臂模块(1)的Y轴机械臂和Z轴机械臂(1-4)外罩设有防尘罩(1-10)。
  5. 根据权利要求1所述的全自动化学发光免疫分析仪，其特征在于：所述取试管抓手装置(2)安装在安装壳内。
  6. 根据权利要求1所述的全自动化学发光免疫分析仪，其特征在于：所述反应管模块(6)，样品管模块(4)，试剂盒模块(5)，三维机械臂模块(1)，取试管抓手装置(2)，混匀结构(3)，温育仓(7)和清洗装置(9)安装在透明机架(11)内。
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