WO2022218226A1 - Cellule immunitaire modifiée et son utilisation - Google Patents
Cellule immunitaire modifiée et son utilisation Download PDFInfo
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- WO2022218226A1 WO2022218226A1 PCT/CN2022/085847 CN2022085847W WO2022218226A1 WO 2022218226 A1 WO2022218226 A1 WO 2022218226A1 CN 2022085847 W CN2022085847 W CN 2022085847W WO 2022218226 A1 WO2022218226 A1 WO 2022218226A1
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- cells
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Definitions
- the cell surface molecule that specifically recognizes an antigen binds to a target selected from CD7, CD2, CD5, CD3, CD73, CD47, VEGF, GUCY2C, EGP40, EGP-2, CD133, IFNAR1, DLL3, kappa light chain, TIM3, CD70, TSHR, CD19, CD123, CD22, BAFF-R, CD30, CD171, CS-1, CLL-1, CD33, EGFRvIII, GD2, GD3, BCMA, GPRC5D, Tn antigen, PSMA , ROR1, FLT3, FAP, TAG72, CD38, CD44v6, CEA, EPCAM, B7H3, KIT, IL-13Ra2, mesothelin, IL-11Ra, PSCA, PRSS21, VEGFR2, LewisY, CD24, PDGFR- ⁇ , SSEA- 4.
- a target selected from CD7, CD2, CD5, CD3, CD73, CD47, VEGF, GUCY2C, E
- the costimulatory domain is one or more intracellular domains selected from the group consisting of TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, CARD11, CD2, CD7, CD8, CD18, CD27, CD28, CD30, CD40, CD54, CD83, CD134(OX40), CD137(4-1BB), CD270(HVEM), CD272(BTLA), CD276(B7-H3), CD278(ICOS ), CD357 (GITR), DAP10, DAP12, LAT, NKG2C, SLP76, PD-1, LIGHT, TRIM, ZAP70, and combinations thereof.
- the costimulatory domain is selected from the intracellular region of CD27, CD28, CD134, CD137, DAP10, DAP12 or CD278 or a combination thereof.
- the subject is pretreated with one or more chemotherapeutic agents to deplete lymphocytes prior to receiving the engineered immune cells of the invention.
- the chemotherapeutic agent is selected from cyclophosphamide, fludarabine, bendamustine, taxanes or combinations thereof, preferably cyclophosphamide, fludarabine or combinations thereof.
- the masking peptide can mask the extracellular binding domain, preventing it from binding to the targeted antigen, and when the masking peptide is cleaved by, for example, a protease, the extracellular binding domain can be exposed, making it a "normal" CAR structure.
- Various switch structures known to those skilled in the art can be used in the present invention.
- the vectors of the present invention include, but are not limited to, plasmids, viruses (eg, retroviruses, lentiviruses, adenoviruses, vaccinia virus, Rous sarcoma virus (RSV, polyoma virus, and adeno-associated virus (AAV)), and the like ), phages, phagemids, cosmids, and artificial chromosomes (including BAC and YAC).
- viruses eg, retroviruses, lentiviruses, adenoviruses, vaccinia virus, Rous sarcoma virus (RSV, polyoma virus, and adeno-associated virus (AAV)
- RSV Rous sarcoma virus
- AAV adeno-associated virus
- allogeneic refers to any material derived from a different animal or different patient of the same species as the individual into which the material is introduced. Two or more individuals are considered allogeneic to each other when the genes at one or more loci are different. In some cases, allogeneic material from individuals of the same species may be genetically different enough for antigenic interactions to occur.
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Abstract
La présente invention concerne une cellule immunitaire modifiée exprimant les éléments suivants : (i) une molécule de surface cellulaire reconnaissant spécifiquement un antigène ; et (ii) un XCL2 et/ou XCL1 exogène. La présente invention concerne en outre l'utilisation de la cellule immunitaire modifiée dans le traitement de cancers, d'infections ou de maladies auto-immunes. Par comparaison avec les cellules immunitaires modifiées classiques, la cellule immunitaire modifiée de la présente invention présente une activité de destruction tumorale significativement améliorée.
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CN202111516919.2A CN115216449A (zh) | 2021-04-16 | 2021-12-13 | 工程化免疫细胞及其用途 |
CN202111516919.2 | 2021-12-13 |
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Cited By (2)
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CN116814664A (zh) * | 2023-08-25 | 2023-09-29 | 中国医学科学院肿瘤医院 | 一种扩展肿瘤识别表位的cea嵌合抗原受体t细胞的制备与应用 |
WO2024072820A1 (fr) * | 2022-09-26 | 2024-04-04 | The Regents Of The University Of California | Compositions et méthodes de modulation de la fonction des lymphocytes t |
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CN110964122A (zh) * | 2019-12-24 | 2020-04-07 | 南京北恒生物科技有限公司 | T细胞受体融合蛋白及其用途 |
CN111235113A (zh) * | 2020-01-21 | 2020-06-05 | 南京北恒生物科技有限公司 | 包含嵌合抗原受体的免疫细胞及其用途 |
CN111234033A (zh) * | 2020-01-21 | 2020-06-05 | 南京北恒生物科技有限公司 | 多链嵌合抗原受体及其用途 |
CN111269326A (zh) * | 2020-02-28 | 2020-06-12 | 南京北恒生物科技有限公司 | 新型嵌合抗原受体及其用途 |
CN111849913A (zh) * | 2020-07-31 | 2020-10-30 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
CN111849910A (zh) * | 2020-05-27 | 2020-10-30 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
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CN110964122A (zh) * | 2019-12-24 | 2020-04-07 | 南京北恒生物科技有限公司 | T细胞受体融合蛋白及其用途 |
CN111235113A (zh) * | 2020-01-21 | 2020-06-05 | 南京北恒生物科技有限公司 | 包含嵌合抗原受体的免疫细胞及其用途 |
CN111234033A (zh) * | 2020-01-21 | 2020-06-05 | 南京北恒生物科技有限公司 | 多链嵌合抗原受体及其用途 |
CN111269326A (zh) * | 2020-02-28 | 2020-06-12 | 南京北恒生物科技有限公司 | 新型嵌合抗原受体及其用途 |
CN111849910A (zh) * | 2020-05-27 | 2020-10-30 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
CN111849913A (zh) * | 2020-07-31 | 2020-10-30 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2024072820A1 (fr) * | 2022-09-26 | 2024-04-04 | The Regents Of The University Of California | Compositions et méthodes de modulation de la fonction des lymphocytes t |
CN116814664A (zh) * | 2023-08-25 | 2023-09-29 | 中国医学科学院肿瘤医院 | 一种扩展肿瘤识别表位的cea嵌合抗原受体t细胞的制备与应用 |
CN116814664B (zh) * | 2023-08-25 | 2023-12-12 | 中国医学科学院肿瘤医院 | 一种扩展肿瘤识别表位的cea嵌合抗原受体t细胞的制备与应用 |
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