WO2022217397A1 - Analyseur d'immunoessai entièrement automatisé approprié pour l'alimentation et la décharge - Google Patents

Analyseur d'immunoessai entièrement automatisé approprié pour l'alimentation et la décharge Download PDF

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Publication number
WO2022217397A1
WO2022217397A1 PCT/CN2021/086401 CN2021086401W WO2022217397A1 WO 2022217397 A1 WO2022217397 A1 WO 2022217397A1 CN 2021086401 W CN2021086401 W CN 2021086401W WO 2022217397 A1 WO2022217397 A1 WO 2022217397A1
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WO
WIPO (PCT)
Prior art keywords
test paper
outer ring
module
paper box
easy loading
Prior art date
Application number
PCT/CN2021/086401
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English (en)
Chinese (zh)
Inventor
席秋子
许凌杰
Original Assignee
苏州鼎实医疗科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by 苏州鼎实医疗科技有限公司 filed Critical 苏州鼎实医疗科技有限公司
Priority to PCT/CN2021/086401 priority Critical patent/WO2022217397A1/fr
Priority to CN202180000788.4A priority patent/CN115698725A/zh
Publication of WO2022217397A1 publication Critical patent/WO2022217397A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Definitions

  • the present invention relates to the field of in vitro diagnostic POCT. More specifically, the present invention relates to a fully automatic immune analyzer which is convenient for loading and unloading.
  • the existing immunofluorescence analysis device has the following problems: First, the existing support base is set inside the instrument, and the pipette tip tray is set above the support base. When the pipette tip needs to reach into the inside of the instrument, the operator will be nervous due to the influence of the internal motion structure, and worry about causing mechanical injury, and even more personal injury caused by improper operation or instrument failure; secondly, the existing instrument
  • the optical module in the optical module is composed of multiple precision components and selected lenses, which play a vital role in data detection. With the accumulation of the use cycle of the instrument itself, the encounter or change of the external environment may affect the optical module, resulting in inaccurate detection and analysis results.
  • the main purpose of the present invention is to provide a fully automatic immune analyzer that is convenient for loading and unloading, which can move the feeding tray to the outside of the instrument, which is convenient for the pipetting gun in the feeding tray. Fill or take out the pipette head, and at the same time limit the movement process, so that the pipette tip in the material tray can move stably, prevent the pipette tip from being damaged, and improve work efficiency.
  • Another object of the present invention is to provide a fully automatic immune analyzer that is convenient for loading and unloading, which periodically controls the calibrator to be located directly under the optical module through the outer ring drive module, and automatically calibrates the optical module. Reliable and stable, no consumables are generated, cost saving and no manual operation are required, the calibration is fully automatic, the degree of automation is high, the work efficiency is greatly improved, and it has a broad market application value.
  • a fully automatic immunoassay analyzer that facilitates loading and unloading, comprising: a detection module; and
  • the liquid taking module includes: a drawable material preparation drawer assembly; and a mobile liquid taking assembly disposed above the material preparation drawer assembly;
  • the preparation drawer assembly includes: a base;
  • the material tray is arranged above the support base.
  • the material preparation drawer assembly further comprises: at least two limit racks, the two limit racks are mirrored along the horizontal direction, and a material pulling channel of the material tray is defined between the two limit racks ;as well as
  • a limit block which is arranged on the side of the limit frame
  • the limit frame limits the position of the material tray along the vertical direction
  • the limit block limits the position of the material tray along the horizontal direction
  • each of the limiting racks is provided with a limiting portion, and the limiting portion at least partially overlaps with the projection of the material tray in the horizontal direction.
  • a guide rail is provided between the support bracket and the base, and the support bracket is drivingly connected to the movable part of the guide rail.
  • the support bracket includes: a support portion; and
  • the pulling part is integrally formed with the supporting part and extends in a vertical direction to the supporting part.
  • the detection module includes: a support table;
  • An optical component is arranged above the support table, the optical component is located on the outer circumference of the outer ring, and the optical component is wirelessly connected with the data processor; a calibration object is arranged on the top of the outer ring, and the outer ring is The ring is driven to rotate by an outer ring driving module, and the outer ring driving module periodically drives the outer ring to rotate in the forward or reverse direction, so as to control the calibration object to be located directly under the optical assembly.
  • the optical assembly includes: a position trimmer, which is arranged in a horizontal direction;
  • an optical module which is fixedly installed on the surface of the receiving frame
  • the position fine-tuning device drives the optical module to reciprocate along the horizontal direction, so as to fine-tune the position of the optical module.
  • the optical module includes: a fixed frame with a hollow interior; and
  • a laser emitter a dichroic mirror, a first lens, an optical filter, a second lens, a pinhole diaphragm and a detector arranged inside the fixed frame;
  • the first lens, the dichroic mirror, the filter, the second lens, the pinhole diaphragm and the detector are arranged in order from bottom to top along the vertical direction, and the first lens, the dichroic mirror, the filter
  • the light sheet, the second lens, the pinhole diaphragm and the detector are arranged coaxially in the vertical direction, the laser emitter and the dichroic mirror are located at the same height in the vertical direction, and the dichroic mirror is arranged obliquely, so
  • the detector is wirelessly connected to the data processor.
  • the outer ring includes a calibration part, and a positioning groove is formed at the top end of the calibration part, the positioning groove is adapted to the calibration object, and the calibration object is placed in the positioning groove.
  • the inner ring is embedded in the outer ring and arranged concentrically with the outer ring, and at least two stages are fixedly arranged on the outer ring, and the support table is arranged along the inner ring.
  • the circumferential direction of the ring is provided with a test paper blanking station, a test paper box replacement station, and a fluorescence analysis station in sequence and at equal intervals, the inner ring is provided with at least one test paper box, and the optical assembly Set in the fluorescence analysis station.
  • a test paper box seat is fixedly installed on the inner ring, the lower half of the test paper box is detachably inserted into the test paper box seat, and the number of the test paper box seats is the same as the number of the test paper box seats. corresponding to the number of test paper boxes.
  • One of the above technical solutions has the following advantages or beneficial effects: it can move the material tray to the outside of the instrument, which is convenient for filling or taking out the pipette tips in the material tray, and can limit the movement process at the same time, so that the The pipette tips in the tray can move stably to prevent damage to the pipette tips, thereby improving work efficiency.
  • the calibrator is periodically controlled by the outer ring drive module to be located directly under the optical module, and the optical module is automatically calibrated, which is safe, reliable and stable, and no consumables are produced. , Save costs and at the same time do not need manual operation, complete calibration automatically, high degree of automation, greatly improve work efficiency, and have broad market application value.
  • FIG. 1 is a three-dimensional structural view of an automatic immunoassay analyzer that is convenient for loading and unloading according to an embodiment of the present invention
  • FIG. 2 is a three-dimensional structural view of a liquid sampling module and a feeding module in a fully automatic immune analyzer that is convenient for loading and unloading according to an embodiment of the present invention
  • FIG. 3 is a three-dimensional structural view of a material preparation drawer assembly in an automatic immunoassay analyzer for easy loading and unloading according to an embodiment of the present invention
  • FIG. 4 is an exploded structural view of a material preparation drawer assembly in a fully automatic immune analyzer for easy loading and unloading according to an embodiment of the present invention
  • FIG. 5 is an exploded top view of a material preparation drawer assembly in a fully automatic immunoassay analyzer that is convenient for loading and unloading according to an embodiment of the present invention
  • FIG. 6 is a three-dimensional structural view of a detection module in a fully automatic immune analyzer for easy loading and unloading according to an embodiment of the present invention
  • FIG. 7 is a top view of a detection module in a fully automatic immunoassay analyzer that is convenient for loading and unloading according to an embodiment of the present invention
  • FIG. 8 is a three-dimensional structural view of an optical component in a fully automatic immunoassay analyzer that is convenient for loading and unloading according to an embodiment of the present invention
  • Fig. 9 is a partial exploded cross-sectional view when the optical module is matched with the outer ring in the fully automatic immune analyzer convenient for loading and unloading according to an embodiment of the present invention
  • FIG. 10 is a partial cross-sectional view of an optical module and an outer ring in a fully automatic immune analyzer for easy loading and unloading according to an embodiment of the present invention
  • FIG. 11 is a partial cross-sectional view of an optical module and an outer ring in a fully automatic immune analyzer for easy loading and unloading according to an embodiment of the present invention
  • FIG. 12 is a front view of the test paper box and the test paper box seat in the fully automatic immunoanalyzer convenient for loading and unloading proposed according to an embodiment of the present invention
  • FIG. 13 is a three-dimensional structural view of a test paper box and a test paper box seat in a fully automatic immunoassay analyzer that is convenient for loading and unloading according to an embodiment of the present invention
  • Fig. 14 is a working flow chart of a fully automatic immunoassay analyzer that facilitates loading and unloading according to an embodiment of the present invention.
  • a fully automatic immune analyzer that is convenient for loading and unloading includes: a detection module 3 ; and
  • the liquid taking module 1 and the feeding module 2 arranged on the outer periphery of the detection module 3;
  • the liquid taking module 1 includes: a drawable material preparation drawer assembly 11 ; and a mobile liquid taking assembly 12 disposed above the material preparation drawer assembly 11 ;
  • the preparation drawer assembly 11 includes: a base 111;
  • the material tray 117 is arranged above the support base 113 .
  • the material tray 117 includes: a carrying portion 1171;
  • At least two upper limit portions 1172 are integrally formed with the carrying portion 1171 and extend upward along a vertical direction to the carrying portion 1171 . as well as
  • At least two lower limiting portions 1173 are integrally formed with the carrying portion 1171 and extend downward along a vertical direction to the carrying portion 1171 .
  • the pipette tip is placed above the bearing portion 1171 , and the material tray 117 is placed above the support seat 113 through the cooperation between the lower limit portion 1173 and the support seat 113 .
  • the material preparation drawer assembly 11 further includes: at least two limit frames 114 , the two limit frames 114 are mirrored along the horizontal direction, and the space between the two limit frames 114 defines the material tray 117 . pull channel; and
  • a limit block 115 which is arranged on the side of the limit frame 114;
  • the limiting frame 114 limits the position of the material tray 17 along the vertical direction
  • the limiting block 115 limits the position of the material tray 17 along the horizontal direction.
  • a limit portion 1141 is provided at the top of each limit frame 114 , and the limit portion 1141 is at least partially coincident with the projection of the material tray 116 in the horizontal direction.
  • the limiting portion 1141 cooperates with the upper limiting portion 1172 to limit the position of the material tray 17 in the vertical direction.
  • a guide rail 116 is provided between the support bracket 112 and the base 111 , and the support bracket 112 is drivingly connected to the movable part of the guide rail 116 ; the guide rail 116 is connected to the material tray. 117 for guidance.
  • the support bracket 112 includes: a support portion 1121;
  • the pulling part 1122 is integrally formed with the supporting part 1121 and extends in a vertical direction to the supporting part 1121 .
  • the support bracket 112 further includes: a sensing portion 1123, which is integrally formed with the support portion 1121 and extends downward along a vertical direction to the support portion 1121;
  • the base 111 is provided with a position sensor 118 , and the sensing portion 1123 cooperates with the position sensor 1121 to monitor whether the support base 113 is reset.
  • the material preparation drawer assembly 11 further includes: an elastic reset device 119 , and the movable part of the elastic reset device 119 is fixedly connected with the support part 1121 .
  • an elastic reset device 119 By providing the elastic reset device 119, the support base 113 can be reset after being pulled out, and the support base 113 can be locked.
  • the working process of the material preparation drawer assembly 11 is as follows: when the pipette tip is to be filled or taken out, the staff pulls out the support seat 113 through the material pulling part 1122, and then pulls out the material tray 117, and finally moves the material tray 117 to the outside of the instrument to fill tray 117 or remove pipette tips.
  • the limit frame 114 will limit the vertical direction of the support base 113 so that the support base 113 cannot be shaken up and down.
  • the support base 113 cannot be shaken left and right, and finally the support base 113 is pushed to the bottom and the elastic reset device 119 locks the support base 113 so that the support base 113 cannot move back and forth, and the support base 02 is completely positioned.
  • the mobile liquid taking assembly 12 includes: a mobile driving module 121; and a liquid taking pipe 122 drivingly connected with the mobile driving module 121,
  • the moving driving module 121 drives the liquid sampling tube 122 to reciprocate along the X-axis, Y-axis and Z-axis directions respectively.
  • the mobile driving module 121 includes: an X-direction driver 1211;
  • Y-direction driver 1212 which is drivingly connected to the X-direction driver 1211;
  • Z-direction driver 1213 which is drivingly connected with the Y-direction driver 1212;
  • the liquid taking pipe 122 is connected to the Z-direction driver 1213 by transmission;
  • the X-direction driver 1211 drives the liquid taking tube 122 to reciprocate along the X-axis direction
  • the Y-direction driver 1212 drives the liquid-taking tube 122 to reciprocate along the Y-axis direction
  • the Z-direction driver 1213 drives the The liquid pipe 122 reciprocates in the Z-axis direction.
  • the working process of the moving liquid-taking assembly 12 is as follows: the X-direction driver 1211 and the Y-direction driver 1212 drive the liquid-taking pipe 122 to move directly above the material tray 117 , and the Z-direction driver 1213 drives The pipette 122 moves downward along the Z-axis direction to obtain the pipette tip from the material tray 117, and assembles the pipette tip and the pipette 122 into one body; the X-direction driver 1211 And the Y-direction driver 1212 drives the liquid taking pipe 122 to move directly above the feeding module 2, and the Z-direction driver 1213 drives the liquid taking pipe 122 to move down along the Z-axis direction to remove the material from the feeding Module 2 acquires the material liquid to be detected.
  • the X-direction driver 1211 and the Y-direction driver 1212 drive the liquid sampling tube 122 to move to the position of the test paper box replacement station 312.
  • the Z-direction driver 1213 drives the pipette 122 to move downward along the Z-axis direction to drop the material in the pipette tip to the test paper located at the test paper box replacement station 312 for detection
  • the X-direction driver 1211 and the Y-direction driver 1212 drive the liquid taking tube 122 to move directly above the material tray 117
  • the Z-direction driver 1213 drives the liquid taking tube 122 downward along the Z-axis direction Move to place the pipette tip after taking the liquid inside the tray 117, and re-acquire the pipette tip, and repeat the above steps.
  • the detection module 3 includes: a support table 31;
  • An optical component 33 is arranged above the support table 31, the optical component 33 is located on the outer circumference of the outer ring 32, and the optical component 33 is wirelessly connected with the data processor; the top of the outer ring 32 is provided with The calibration object 34, the outer ring 32 is driven and rotated by the outer ring driving module, and the outer ring driving module periodically drives the outer ring 32 to rotate in the forward or reverse direction, so as to control the calibration object 34 to be located at the position of the calibration object 34. directly below the optical assembly 33 .
  • the calibrator 34 is ruby, and ruby contains Cr element, which can undergo electronic transition under the excitation of a laser of a specific wavelength.
  • the data processor is a tablet computer.
  • the optical assembly 33 includes: a position fine-tuning device 331, which is arranged in the horizontal direction;
  • the optical module 333 is fixedly mounted on the surface of the receiving frame 332;
  • the position fine-tuning device 331 drives the optical module 333 to reciprocate along the horizontal direction, so as to fine-tune the position of the optical module 333 .
  • the optical module 333 includes: a fixed frame body 3331 with a hollow interior; and
  • the laser emitter 3332, the dichroic mirror 3333, the first lens 3334, the filter 3335, the second lens 3336, the pinhole aperture 3337 and the detector 3338 are arranged inside the fixed frame 3331;
  • the first lens 3334, the dichroic mirror 3333, the filter 3335, the second lens 3336, the pinhole aperture 3337 and the detector 3338 are arranged in order from bottom to top along the vertical direction, and the first lens 3334, dichroic mirror 3333, filter 3335, second lens 3336, pinhole diaphragm 3337 and detector 3338 are coaxially arranged in the vertical direction, the laser emitter 3331 and the dichroic mirror 3333 are arranged in the vertical direction The directions are at the same height, the dichroic mirror 3333 is inclined and the detector 3338 is wirelessly connected to the data processor.
  • the outer ring 32 includes a calibration part 321 , a positioning groove 3211 is formed at the top of the calibration part 321 , the positioning groove 3211 is adapted to the calibration object 34 , and the calibration object 34 is placed in the positioning inside the groove 3211.
  • a fluorescence focusing groove 3212 is opened inside the calibration part 321 , the fluorescence focusing groove 3212 is located directly below the positioning groove 3211 , and the cross section of the fluorescence focusing groove 3212 is arc-shaped , the surface of the fluorescent focusing groove 3212 is treated with a smooth surface.
  • a fluorescent focusing groove 3212 is opened directly below the positioning groove 3211 where the ruby is placed, and at the same time, the surface of the fluorescent focusing groove 3212 is treated with a smooth surface, so that the fluorescence emitted by the lower end surface of the ruby contacts the fluorescent focusing groove 3212. Refraction occurs immediately after the light surface of the ruby, and the fluorescence generated on the upper end face of the ruby is focused on one point, which greatly reduces the dissipation of fluorescence in other directions, and amplifies the fluorescence signal by increasing the collection surface area.
  • the optical assembly 33 further includes: an alarm, which is wirelessly connected to the data processor.
  • the data processor controls the alarm to issue an alarm to remind the staff to perform manual calibration.
  • the calibration process of the optical module 333 is as follows: the outer ring driving module periodically drives the outer ring 32 to rotate in the forward or reverse direction, so as to control the calibration object 34 to be located in the positive direction of the optical module 333 .
  • the laser emitter 3332 emits excitation light, which is refracted by the dichroic mirror 3333 and then focused on the ruby by the first lens 3334.
  • the ruby is excited to emit fluorescence, and the excited fluorescence is captured by the fluorescence focusing groove 133 Focusing on the focal point of the first lens 3334, after passing through the first lens 3334, the dichroic mirror 3333, the filter 3334, the second lens 3336 and the pinhole aperture 3337 are paralleled After reaching the detector 3338, the detector 3338 reads the fluorescence data and uploads the data to the data processor. Module 333 performs calibration.
  • the inner ring 35 is embedded in the outer ring 32 and arranged concentrically with the outer ring 32 , and at least two stages 322 are fixed on the outer ring 32
  • the support table 31 is provided with a test paper blanking station 311, a test paper box replacement station 312, and a fluorescence analysis station 313 in sequence and at equal intervals along the circumferential direction of the inner ring 35, so At least one test paper box 36 is arranged on the inner ring 35 , and the optical assembly 33 is arranged in the fluorescence analysis station 313 .
  • the outer circumference of the inner ring 35 is in sliding contact with the inner circumference of the outer ring 32 , so that the inner ring 35 and the outer ring 32 can perform smooth and stable relative rotation.
  • test paper box seat 38 is fixedly installed on the inner ring 35, and the lower half of the test paper box 36 is detachably inserted into the test paper box seat 38,
  • the number of the test paper box seats 38 corresponds to the number of the test paper boxes 36 .
  • the root of the test paper box seat 38 is provided with a test paper push-out port 381 running through its front and rear sides, and the bottom of the test paper box 36 is provided with a test paper self-dropping groove that communicates with the test paper push-out port 381. 361.
  • the front side of the test paper box seat 38 is provided with a left guide seat 382 and a right guide seat 383 respectively located on the left and right sides of the test paper ejection port 381, and the left guide seat 382 and the right guide seat 383 are respectively provided with oppositely arranged left guide seats.
  • the surfaces of the groove 3821, the right guide groove 3831, the left guide groove 3821 and the right guide groove 3831 and the bottom surface of the test paper from the drop groove 361 are located on the same level, so that the test paper pushed out from the test paper from the drop groove 361 can be pushed out by the left guide groove 3821.
  • the right guide groove 3831 smoothly receives and guides it to the test paper carrying groove to wait for the subsequent dripping operation.
  • test paper boxes 36 are provided at equal intervals in the circumferential direction of the inner ring 35 .
  • the inner ring 35 is driven to rotate by the inner ring driving module, the support table 31 is also provided with a test paper pushing unit, and the inner ring 35 is provided with an inner ring rotation angle sensor 351 for sensing the rotation angle of the inner ring 35 .
  • a buffer plate 37 is provided on the side of each test paper box 36 .
  • the outer ring driving module drives the outer ring 32 so that a test paper carrying slot on the outer ring 32 is opposite to the test paper ejection port 381, and the test paper ejection unit pushes outward, so that the test paper on the test paper unloading station 311 is pushed out.
  • the bottommost test paper in the paper box 36 is pushed into the test paper carrier;
  • the outer ring 32 is driven to rotate one test paper carrier station counterclockwise, so that the next test paper carrier and the test paper ejection port 381, and the previous test paper carrier rotates the previous test paper to the side of the buffer plate 37.
  • the blood sample, buffer, and fluorescently labeled antibody solution are sequentially added dropwise to the previous test paper by the manipulator;
  • the outer ring 32 rotates counterclockwise continuously and at intervals, so that the first test strip carrying the blood sample is rotated to the fluorescence analysis station 313 to receive the fluorescence analysis of the optical assembly 33. After the analysis of the first test paper is completed, the outer ring 32 Continue to turn counterclockwise to the waste disposal station. With the assistance of the manipulator, the analytical test strips are collected and processed in a centralized manner, and the cycle is repeated until all the collected blood samples are analyzed.
  • the inner ring 35 is rotated by 120°, so that the test paper box 36 at the fluorescence analysis station 313 is rotated to the bottom of the test paper
  • the test paper box 36 at the test paper box replacement station 312 is rotated to the fluorescence analysis station 313, and the test paper box 36 at the test paper unloading station 311 is rotated to the test paper box replacement station.
  • the replacement operation of the full/empty test paper box 36 can be performed at the test paper box replacement station 312, which greatly shortens the replacement time of the test paper box 36 and improves the analysis efficiency.
  • workflow of the present invention is:
  • the automatic immune analyzer performs self-checking and initialization operations
  • the optical module 333 is automatically calibrated
  • the sample tube is placed on the loading module 2
  • the sample testing mode is activated
  • the liquid-taking assembly 12 is moved to Above the preparation drawer assembly 11, after the pipette tip is automatically assembled, move to the top of the sample tube to absorb the sample liquid, then move to the top of the buffer plate 37, pierce the film of the buffer plate 37, and mix the sample solution with the buffer solution.
  • the inner ring drive module drives the test paper box 36 to rotate to the test paper unloading station 311, and the outer ring drive module drives the outer ring 32 to make a test paper carrier slot and a test paper ejection port on it.
  • the test paper pushing unit pushes the bottommost test paper in the test paper box 36 on the test paper unloading station 311 into the test paper carrier groove, and the moving liquid collecting assembly 12 will suck the mixed solution to the test paper unloading station 311.
  • the sample is added at the position of the test paper, and the outer ring 32 continues to rotate, so that the test paper carries the mixed solution and rotates to the fluorescence analysis station 313 to receive the fluorescence analysis of the optical assembly 33.
  • the outer ring 32 continues to rotate counterclockwise to the waste. Discard the station, collect the analyzed test strips in a centralized manner, move the liquid sampling assembly 12 to the top of the material preparation drawer assembly, discard the pipette tips, and enter the next cycle.

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un analyseur d'immunoessai entièrement automatisé approprié pour l'alimentation et la décharge, comprenant : un module de test (3) ; et un module de prélèvement de liquide (1) et un module d'alimentation (2) qui sont agencés sur la périphérie du module de test (3). Le module de prélèvement de liquide (1) comprend : un ensemble tiroir de préparation de matériau (11) pouvant être tiré ; et un ensemble de prélèvement de liquide mobile (12) disposé au-dessus de l'ensemble tiroir de préparation de matériau (11). L'ensemble tiroir de préparation de matériau (11) comprend : une base (111) ; un cadre de support (112) disposé de manière mobile au-dessus de la base (111) ; une base de support (113) montée à demeure au-dessus du cadre de support (112) ; et un plateau (117) disposé au-dessus de la base de support (113). Selon l'analyseur d'immunoessai entièrement automatisé, le plateau (117) peut être déplacé vers l'extérieur de l'analyseur pour faciliter le remplissage ou le retrait d'une tête de pipetage dans le plateau (117) et un processus de mouvement peut être limité en position de telle sorte que la tête de pipetage dans le plateau (117) puisse se déplacer de manière stable pour empêcher un endommagement de la tête de pipetage, ce qui permet d'améliorer l'efficacité de travail.
PCT/CN2021/086401 2021-04-12 2021-04-12 Analyseur d'immunoessai entièrement automatisé approprié pour l'alimentation et la décharge WO2022217397A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/CN2021/086401 WO2022217397A1 (fr) 2021-04-12 2021-04-12 Analyseur d'immunoessai entièrement automatisé approprié pour l'alimentation et la décharge
CN202180000788.4A CN115698725A (zh) 2021-04-12 2021-04-12 一种便于上下料的全自动免疫分析仪

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2021/086401 WO2022217397A1 (fr) 2021-04-12 2021-04-12 Analyseur d'immunoessai entièrement automatisé approprié pour l'alimentation et la décharge

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WO2022217397A1 true WO2022217397A1 (fr) 2022-10-20

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PCT/CN2021/086401 WO2022217397A1 (fr) 2021-04-12 2021-04-12 Analyseur d'immunoessai entièrement automatisé approprié pour l'alimentation et la décharge

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CN (1) CN115698725A (fr)
WO (1) WO2022217397A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116754758A (zh) * 2023-08-24 2023-09-15 遂宁市中心医院 一种脓毒症免疫功能监测设备
CN117405903A (zh) * 2023-12-13 2024-01-16 阅尔基因技术（苏州）有限公司 一种检测男性不孕不育基因的试剂盒及其使用方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5415840A (en) * 1992-10-19 1995-05-16 Hitachi, Ltd. Liquid sample automatic analyzer
CN104111328A (zh) * 2013-04-16 2014-10-22 深圳迈瑞生物医疗电子股份有限公司 样本检测装置及样本检测方法
CN107356776A (zh) * 2017-07-28 2017-11-17 珠海迪尔医疗设备研究院有限公司 一种全自动细菌性阴道病检测仪
CN108614101A (zh) * 2018-03-14 2018-10-02 嘉兴科瑞迪医疗器械有限公司 一种磁微粒全自动化学发光免疫分析仪
CN110596408A (zh) * 2019-09-20 2019-12-20 苏州鼎实医疗科技有限公司 一种全自动干式免疫分析设备
CN210037827U (zh) * 2019-02-20 2020-02-07 苏州鼎实医疗科技有限公司 一种全自动免疫荧光分析装置
CN210108953U (zh) * 2019-01-29 2020-02-21 深圳市中科同辉科技有限公司 一种poct荧光分析仪检测光路
CN210954069U (zh) * 2019-10-28 2020-07-07 东方伊诺(苏州)医疗科技有限公司 一种自动酶联免疫分析仪
CN112082981A (zh) * 2020-10-15 2020-12-15 上海阳泰医疗科技有限公司 一种抗体荧光自动检测仪

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5415840A (en) * 1992-10-19 1995-05-16 Hitachi, Ltd. Liquid sample automatic analyzer
CN104111328A (zh) * 2013-04-16 2014-10-22 深圳迈瑞生物医疗电子股份有限公司 样本检测装置及样本检测方法
CN107356776A (zh) * 2017-07-28 2017-11-17 珠海迪尔医疗设备研究院有限公司 一种全自动细菌性阴道病检测仪
CN108614101A (zh) * 2018-03-14 2018-10-02 嘉兴科瑞迪医疗器械有限公司 一种磁微粒全自动化学发光免疫分析仪
CN210108953U (zh) * 2019-01-29 2020-02-21 深圳市中科同辉科技有限公司 一种poct荧光分析仪检测光路
CN210037827U (zh) * 2019-02-20 2020-02-07 苏州鼎实医疗科技有限公司 一种全自动免疫荧光分析装置
CN110596408A (zh) * 2019-09-20 2019-12-20 苏州鼎实医疗科技有限公司 一种全自动干式免疫分析设备
CN210954069U (zh) * 2019-10-28 2020-07-07 东方伊诺(苏州)医疗科技有限公司 一种自动酶联免疫分析仪
CN112082981A (zh) * 2020-10-15 2020-12-15 上海阳泰医疗科技有限公司 一种抗体荧光自动检测仪

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116754758A (zh) * 2023-08-24 2023-09-15 遂宁市中心医院 一种脓毒症免疫功能监测设备
CN116754758B (zh) * 2023-08-24 2023-10-20 遂宁市中心医院 一种脓毒症免疫功能监测设备
CN117405903A (zh) * 2023-12-13 2024-01-16 阅尔基因技术（苏州）有限公司 一种检测男性不孕不育基因的试剂盒及其使用方法
CN117405903B (zh) * 2023-12-13 2024-02-20 阅尔基因技术（苏州）有限公司 一种检测男性不孕不育基因的试剂盒及其使用方法

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