WO2022211933A1 - Nouveau système conservateur, et composition cosmétique le comprenant - Google Patents

Nouveau système conservateur, et composition cosmétique le comprenant Download PDF

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Publication number
WO2022211933A1
WO2022211933A1 PCT/US2022/017624 US2022017624W WO2022211933A1 WO 2022211933 A1 WO2022211933 A1 WO 2022211933A1 US 2022017624 W US2022017624 W US 2022017624W WO 2022211933 A1 WO2022211933 A1 WO 2022211933A1
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WIPO (PCT)
Prior art keywords
acid
cosmetic composition
preservative system
zinc
salts
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PCT/US2022/017624
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English (en)
Inventor
Michele Nicole CRISTIANO
Noah Louis Wieder
Mark Zaw
Original Assignee
L'oreal
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Filing date
Publication date
Priority claimed from US17/218,797 external-priority patent/US20220313575A1/en
Priority claimed from FR2107903A external-priority patent/FR3125415B1/fr
Application filed by L'oreal filed Critical L'oreal
Priority to CN202280023038.3A priority Critical patent/CN117062592A/zh
Priority to EP22708706.1A priority patent/EP4312958A1/fr
Priority to JP2023559793A priority patent/JP2024512996A/ja
Priority to KR1020237033747A priority patent/KR20230154923A/ko
Publication of WO2022211933A1 publication Critical patent/WO2022211933A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
    • A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A01N59/20—Copper
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/524—Preservatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the instant disclosure relates to preservative systems for keratinous tissue, particularly skin, that include salicylic acid, benzoic acid or its salts and divalent transition metal salts.
  • Preservatives are commonly used in personal care products. Preservatives are aimed at protecting such products from decay or spoilage, mainly caused by microorganisms. They typically possess anti-microbial activity.
  • preservative agents may cause adverse effects such as allergic responses and skin irritation, it is desirable to use them in the smallest amount possible in the cosmetics or other personal care products.
  • a balance must be achieved by having an effective anti-microbial amount of the preservative or preservatives in the product, yet having that amount be as small as possible to avoid or reduce the chance of adverse effects.
  • the preservative or blend of preservatives be effective against the widest possible types of potentially harmful microorganisms that could cause decay or spoilage of personal care products.
  • such preservatives should be chemically and physically compatible with the other ingredients in the personal care product.
  • the instant disclosure relates to preservative systems that are unique in comparison to well-known preservative systems because they aim to preserve highly natural formulas without the use of petrochemicals or alcohol to be suitable for all products formats including a jar packaging, which requires the most stringent level of challenge testing due to the product being exposed to the most contact with the environment. While not wishing to be bound by any particular theory, the inventors believe that the combination of salicylic acid, benzoic acid and one or more divalent metal salts contribute to the preservation of highly natural cosmetic systems.
  • the preservative system typically includes: a. salicylic acid; b. weak organic acid or its salts; c. of one or more divalent transition metal salts.
  • the weak organic acid or its salts is chosen from benzoic acid, sorbic acid, levulinic acid, anisic acid, dehydroacetic acid, propionic acid and combinations thereof. In one embodiment, the weak organic acid or its salts is benzoic acid or its salts.
  • the preservative system includes one or more divalent metal salts are chosen from a divalent metal salt of an organic acid, a divalent metal salt of an inorganic acid, and combinations thereof. In one or more embodiments, the one or more divalent metal salts are chosen from salts of zinc, nickel, copper, silver, manganese, cobalt, and combinations thereof.
  • the one or more divalent metal salts include divalent metal salts of an organic acid chosen from zinc lactate, zinc gluconate, zinc phenolsulfonate, zinc salicylate, zinc pyrrolidone carboxylic acid (Zinc PCA), zinc citrate, zinc ascorbate, copper gluconate, copper sulfate, their salt derivatives, and combinations thereof.
  • an organic acid chosen from zinc lactate, zinc gluconate, zinc phenolsulfonate, zinc salicylate, zinc pyrrolidone carboxylic acid (Zinc PCA), zinc citrate, zinc ascorbate, copper gluconate, copper sulfate, their salt derivatives, and combinations thereof.
  • the one or more divalent metal salts include divalent metal salts of an inorganic acid chosen from metal halides, metal hydroxides, metal sulfates, metal oxides, and combinations thereof. In one embodiments, the one or more divalent metal salts of an inorganic acid are chosen from salts of zinc, nickel, copper, silver, manganese, cobalt, and combinations thereof.
  • the one or more divalent metal salts of an organic acid includes a zinc salt.
  • the zinc salt is zinc gluconate.
  • some embodiments may include a cosmetic composition comprising the preservative system described in the instant disclosure, a suitable carrier system, and additives selected from fatty compounds, fillers, polymers, surfactants, solvents, essential oils, vegetal extract, conditioners, emollients, skin caring ingredients, thickeners, anti-oxidants, other preservatives, active ingredients, fragrances and combination thereof.
  • the one or more divalent metal salts is present from about 0.01 to about 0.5 wt.% based on the total weight of the cosmetic composition.
  • the salicylic acid is present from about 0.01 to about 0.5 wt.% based on the total weight of the cosmetic composition. In some embodiments, the benzoic acid is present from about 0.01 to about 0.3 wt.% based on the total weight of the cosmetic composition.
  • the cosmetic composition is in the form of an oil- in-water emulsion. In one embodiment, the cosmetic composition is in the form of a water- in-oil emulsion. In one or more embodiments, the preservative systems describe in the instant disclosure may be used in hair compositions, skin care compositions, cleansing compositions, makeup compositions.
  • the preservative system of the instant disclosure contains salicylic acid, benzoic acid, one or more divalent transition metal salts and can be added to other cosmetic compositions.
  • the cosmetic compositions may contain solvents or any of the other components mentioned hereinafter as components that can be added to the compositions according to the instant disclosure.
  • the compositions of the instant disclosure may be prepared by mixing the salicylic acid, the benzoic acid and the divalent metal salts. Solvent may be added after mixing or the components are mixed while being present in a solvent. Other components may be added during the mixing or afterwards.
  • the said salicylic acid, benzoic acid, divalent metal salts may also be added to a premix of other components.
  • a cosmetic composition may include a preservative system comprising salicylic acid, benzoic acid, one or more divalent transition metal salts and some additives selected from fatty compounds, fillers, surfactants, solvents, essential oils, vegetal extract, conditioners, emollients, skin caring ingredients, thickeners, anti-oxidants, other preservatives, active ingredients, fragrances and combination thereof.
  • a preservative system comprising salicylic acid, benzoic acid, one or more divalent transition metal salts and some additives selected from fatty compounds, fillers, surfactants, solvents, essential oils, vegetal extract, conditioners, emollients, skin caring ingredients, thickeners, anti-oxidants, other preservatives, active ingredients, fragrances and combination thereof.
  • compositions comprising the novel preservative system that are appropriate for topical application to the keratinous tissue, such as skin, include composition in the form of a lotion, serum, gel, milk, liquid foundation or cream.
  • Suitable cosmetic system which include the novel preservative system include lotion or serum type of emulsions with a liquid or semi-liquid consistency of the milk type, obtained by dispersion of a fatty phase in an aqueous phase (O/W) or vice versa (W/O), including those employing silicone and non-silicone oils, or of suspensions or emulsions with a soft consistency of the aqueous gel or cream type, or of microcapsules or microparticles, or of vesicular dispersions of ionic and/or nonionic type or of foams, or they may be provided in the form of toners or micellar water, or they may be biphasic and include water and other solvents such as alcohols and other water-soluble solvents and oils that are not water miscible.
  • Biphasic compositions require pre-application agitation to form an emulsion prior to application to the keratinous tissue, such as skin, which emulsion is of sufficient quality and stability to allow a uniform application of the emulsified phases.
  • a suitable carrier system according to the disclosure may be selected from any one of oil-in-water emulsions, water -in-oil emulsions, silicone in water emulsions, dispersions, micellar waters, biphasic compositions, and foams.
  • the cosmetic composition can be in the form of an oil-in-water emulsion. In some embodiments, the cosmetic composition is in the form of a water-in-oil emulsion. In some embodiments, the cosmetic composition is an aqueous system, aqueous serum, gel, light lotion, shampoo.
  • compositions having a preservative system comprising: a. from 0.01 to 0.5 wt.% of salicylic acid; b. from 0.01 to 0.3 wt.% of benzoic acid or its salts; c. one or more divalent transition metal salts.
  • compositions may include:
  • a preservative system comprising: a. from 0.01 to 0.5 wt.% of salicylic acid; b. from 0.01 to 0.3 wt.% of benzoic acid or its salts; c. from about 0.01 to about 0.5 wt.% of one or more divalent transition metal salts;
  • the instant disclosure is related to a method of preserving a composition by incorporating the preservative system described in the instant disclosure.
  • the instant disclosure relates to preservative systems that are unique in comparison to well-known preservative systems because they aim to preserve highly natural formulas without the use of petrochemicals or alcohol to be suitable for all products formats including a jar packaging, which requires the most stringent level of challenge testing due to the product being exposed to the most contact with the environment.
  • the preservative system typically includes: a. salicylic acid; b. weak organic acid or its salts; c. of one or more divalent transition metal salts.
  • preservative system or “preservative” used herein is understood to refer to preservative compositions that include ingredients that have both anti-microbial and anti-oxidant effects that can be incorporated into cosmetic and personal care formulations, thus would enhance the shelf life of such cosmetic and personal care formulations.
  • solubility used herein is understood to explain the ability to dissolve into a homogeneous solution with no change in visual or microscope cloudiness or particulates.
  • the preservative system according to the disclosure comprises salicylic acid.
  • Salicylic acid (from Latin salix, willow tree) is a lipophilic monohydroxybenzoic acid, a type of phenolic acid, and a beta hydroxy acid (BHA). It has the formula C7H603. This colorless crystalline organic acid is widely used in organic synthesis and functions as a plant hormone.
  • the amount of salicylic acid present in the preservative system is in a range from about 1 .5 to about 95 wt.%, or from about 2.0 to about 94.5 wt.%, or from about 4.0 to about 91 wt.%, or from about 5.0 to about 90 wt.%, or from about 7.0 to about 89% wt.%, from about 10 to about 80% wt.%, from about 15 to about 75 wt.% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the preservative system.
  • any one of or a combination of salicylic acid is present, by weight, based on the total weight of the preservative system, from about 1.5, 1.8, 2.0, 2.2, 2.4, 2.6,
  • the amount of salicylic acid present in a cosmetic composition is in a range from about 0.01 to about 0.5 wt.%, or from about 0.05 to about 0.48 wt.%, or from about 0.1 to about 0.46 wt.%, or from 0.15 to about 0.4 wt%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • any one of or a combination of salicylic acid is present, by weight, based on the total weight of the cosmetic composition, from about 0.01 , 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.11 , 0.12, 0.13, 0.14, 0.15 to about 0.15, 0.16, 0.17, 0.18, 0.19, 0.20, 0.21 , 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.3, 0.31 , 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.4, 0.41 , 0.42, 0.43, 0.44, 0.45, 0.46, 0.47, 0.48, 0.49 or 0.5 wt.% including increments and ranges therein and there between.
  • the preservative system according to the disclosure comprises weak organic acid or its salts.
  • the amount of weak organic acids or its salts present in the preservative system is in a range from about 1 .5 to about 95 wt.%, or from about 2.0 to about 94.5 wt.%, or from about 4.0 to about 91 wt.%, or from about 5.0 to about 90 wt.%, or from about 7.0 to about 89% wt.%, from about 10 to about 80% wt.%, from about 15 to about 75 wt.% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the preservative system.
  • any one of or a combination of weak organic acid or its salts is present, by weight, based on the total weight of the preservative system, from about 1.5, 1.8, 2.0, 2.2,
  • the weak organic acid may be chosen from benzoic acid, sorbic acid, levulinic acid, anisic acid, dehydroacetic acid, propionic acid and combinations thereof.
  • the amount of benzoic acid present in the preservative system is in a range from about 1 .5 to about 95 wt.%, or from about 2.0 to about 94.5 wt.%, or from about 4.0 to about 91 wt.%, or from about 5.0 to about 90 wt.%, or from about 7.0 to about 89% wt.%, from about 10 to about 80% wt.%, from about 15 to about 75 wt.% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the preservative system.
  • any one of or a combination of benzoic acid is present, by weight, based on the total weight of the preservative system, from about 1.5, 1 .8, 2.0, 2.2, 2.4, 2.6, 2.8, 3.0, 3.2, 3.4, 3.6, 3.8, 4.0, 4.2, 4.4, 4.6, 4.8, 5.0, 5.2, 5.4, 5.6, 5.8, 6.0, 6.2, 6.4, 6.8, 7.0, 7.2,
  • the amount of weak organic acid present in a cosmetic composition is in a range from about 0.01 to about 0.3 wt.%, or from about 0.05 to about 0.28 wt.%, or from about 0.1 to about 0.2 wt.%, or from 0.15 to about 0.24 wt.%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • any one of or a combination of weak organic acid is present, by weight, based on the total weight of the cosmetic composition, from about 0.01 , 0.02, 0.03,
  • the amount of divalent transition metal salts present in the preservative system is in a range from about 1.5 to about 95 wt.%, or from about 2.0 to about 94.5 wt.%, or from about 4.0 to about 91 wt.%, or from about 5.0 to about 90 wt.%, or from about 7.0 to about 89% wt.%, from about 10 to about 80% wt.%, from about 15 to about 75 wt.% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the preservative system.
  • any one of or a combination of divalent transition metal salts is present, by weight, based on the total weight of the preservative system, from about 1 .5, 1.8, 2.0, 2.2,
  • the amount of divalent metal salts present in a cosmetic composition is in a range from about 0.01 to about 0.5 wt.%, or from about 0.05 to about 0.48 wt.%, or from about 0.1 to about 0.46 wt.%, or from 0.15 to about 0.44 wt%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • any one of or a combination of divalent metal salts is present, by weight, based on the total weight of the cosmetic composition, from about 0.01 , 0.02, 0.03,
  • the one or more divalent metal salts of an inorganic acid may be chosen from metal halides, metal hydroxides, metal sulfates, metal oxides, and combinations thereof.
  • Suitable examples of the one or more divalent metal salts of an inorganic acid may be chosen from zinc chloride, zinc sulfate, zinc nitrate, zinc carbonate and hydrogen carbonate, zinc phosphate, and combinations thereof.
  • the amount of divalent metal salts of an inorganic acid present in the preservative system is in a range from about 1.5 to about 95 wt.%, or from about 2.0 to about 94.5 wt.%, or from about 4.0 to about 91 wt.%, or from about 5.0 to about 90 wt.%, or from about 7.0 to about 89% wt.%, from about 10 to about 80% wt.%, from about 15 to about 75 wt.% or any suitable combination, sub combination, range, or sub-range thereof by weight, based on the weight of the preservative system.
  • any one of or a combination of divalent transition metal salts of an inorganic acid is present, by weight, based on the total weight of the preservative system, from about 1.5, 1.8, 2.0, 2.2, 2.4, 2.6, 2.8, 3.0, 3.2, 3.4, 3.6, 3.8, 4.0, 4.2, 4.4, 4.6, 4.8, 5.0, 5.2, 5.4, 5.6, 5.8, 6.0, 6.2, 6.4, 6.8, 7.0, 7.2, 7.4, 7.6, 7.8, 8.0, 8.2, 8.4, 8.6, 8.8, 9.0, 9.2, 9.4, 9.6, 9.8, 10.0, 12.0.
  • the amount of divalent metal salts of an inorganic acid present in a cosmetic composition is in a range from about 0.01 to about 0.5 wt.%, or from about 0.05 to about 0.48 wt.%, or from about 0.1 to about 0.46 wt.%, or from 0.15 to about 0.44 wt%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • any one of or a combination of divalent metal salts of an inorganic acid is present, by weight, based on the total weight of the cosmetic composition, from about 0.01 , 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.11 , 0.12, 0.13, 0.14, 0.15 to about 0.15, 0.16, 0.17, 0.18, 0.19, 0.20, 0.21 , 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.3, 0.31 , 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.4, 0.41 , 0.42, 0.43, 0.44, 0.45, 0.46, 0.47, 0.48, 0.49, or 0.5 wt.% including increments and ranges therein and there between.
  • the one or more divalent metal salts of an organic acid may be chosen from metal salts wherein the organic acid is chosen from C1 to C9 monocarboxylic or di-carboxylic acids, polycarboxylic acids, hydroxy-carboxylic acids, and fatty acids having at least 10 carbon atoms including ascorbic acid, formic acid, acetic acid, glycolic acid, gluconic acid, lactic acid, mandelic acid, oxalic acid, maleic acid, malonic acid, glyoxylic acid, succinic acid, adipic acid, fumaric acid, sebacic acid, including citric acid, tartaric acid, malic acid, 2-hydroxy malonic acid, 2-hydroxyl n-butyl 1 ,2,4-tricarboxylic acid, glutaric acid, glucaric acid, 2-hydroxy n-butyl 1 ,3,4-tricarboxylic acid, pyrrolidone carboxylic acid, and phenolsulfonic acid.
  • the organic acid is chosen from
  • the one or more divalent metal salts of an organic acid are chosen from zinc lactate, zinc gluconate, zinc phenolsulfonate, zinc salicylate, zinc pyrrolidone carboxylic acid (Zinc PCA), zinc ascorbate, zinc citrate, their salt derivatives thereof, and combinations thereof.
  • the one or more divalent metal salts of an organic acid includes a zinc salt.
  • the zinc salt is zinc gluconate.
  • the amount of divalent metal salts of an organic acid present in the preservative system is in a range from about 1.5 to about 95 wt.%, or from about 2.0 to about 94.5 wt.%, or from about 4.0 to about 91 wt.%, or from about 5.0 to about 90 wt.%, or from about 7.0 to about 89% wt.%, from about 10 to about 80% wt.%, from about 15 to about 75 wt.% or any suitable combination, sub combination, range, or sub-range thereof by weight, based on the weight of the preservative system.
  • any one of or a combination of divalent transition metal salts of an organic acid is present, by weight, based on the total weight of the preservative system, from about 1.5, 1.8, 2.0, 2.2, 2.4, 2.6, 2.8, 3.0, 3.2, 3.4, 3.6, 3.8, 4.0, 4.2, 4.4, 4.6, 4.8, 5.0, 5.2, 5.4, 5.6, 5.8, 6.0, 6.2, 6.4, 6.8, 7.0, 7.2, 7.4, 7.6, 7.8, 8.0, 8.2, 8.4, 8.6, 8.8, 9.0, 9.2, 9.4, 9.6, 9.8, 10.0, 12.0.
  • the amount of divalent metal salts of an organic acid present in a cosmetic composition is in a range from about 0.01 to about 0.5 wt.%, or from about 0.05 to about 0.48 wt.%, or from about 0.1 to about 0.46 wt.%, or from 0.15 to about 0.44 wt%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • any one of or a combination of divalent metal salts of an organic acid is present, by weight, based on the total weight of the cosmetic composition, from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.11, 0.12, 0.13, 0.14, 0.15 to about 0.15, 0.16, 0.17, 0.18, 0.19, 0.20, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.3, 0.31, 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.4, 0.41, 0.42, 0.43, 0.44, 0.45, 0.46, 0.47, 0.48, 0.49, or 0.5 wt.% including increments and ranges therein and there between.
  • compositions can also comprise at least one additive conventionally used in the cosmetics field which does not affect the properties of the compositions according to the invention, such as thickeners, pearlescent agents, preservatives, sunscreens, anionic or nonionic or cationic or amphoteric polymers, proteins, protein hydrolysates, fatty acids, silicones, vegetable, mineral or synthetic oils, gelling agents, fragrances, fillers, screening agents, odor absorbers and coloring materials.
  • additives conventionally used in the cosmetics field which does not affect the properties of the compositions according to the invention, such as thickeners, pearlescent agents, preservatives, sunscreens, anionic or nonionic or cationic or amphoteric polymers, proteins, protein hydrolysates, fatty acids, silicones, vegetable, mineral or synthetic oils, gelling agents, fragrances, fillers, screening agents, odor absorbers and coloring materials.
  • any one or a combination of additives can be present in the composition according to the invention in proportions which are not limited, but which advantageously fall in the range from 0% to 90% by weight, or 1 to 90% by weight, with respect to the total weight of the cosmetic composition.
  • any composition of the invention can be topically applied to the skin (over any cutaneous region of the body) or to the mucous membranes (oral, jugal, gingival, genital, conjunctival, and the like).
  • the composition can be provided in any dosage form normally used.
  • the composition can have the form in particular of aqueous or oily solutions or of dispersions of the lotion or serum type of emulsions with a liquid or semi-liquid consistency of the milk type, obtained by dispersion of a fatty phase in an aqueous phase (O/W) or vice versa (W/O), including those employing silicone and non-silicone oils, or of suspensions or emulsions with a soft consistency of the aqueous gel or cream type, or of microcapsules or microparticles, or of vesicular dispersions of ionic and/or nonionic type or of foams, or they may be provided in the form of toners or micellar water, or they may be biphasic and include water and other solvents such as alcohols and other water-soluble solvents and oils that are not water miscible.
  • Biphasic compositions require pre-application agitation to form an emulsion prior to application to the keratinous tissue, such as skin, which emulsion is of sufficient quality and stability to allow a uniform application of the emulsified phases.
  • a suitable carrier system according to the disclosure may be selected from any one of oil- in-water emulsions, water -in-oil emulsions, silicone in water emulsions, dispersions, micellar waters, biphasic compositions, and foams. These compositions are prepared according to the usual methods.
  • compositions according to the invention are those conventionally used in the fields under consideration.
  • these compositions constitute in particular creams for cleaning, protecting, treating or caring for the face, for the hands, for the feet, for the major anatomical folds or for the body (for example, day creams, night creams, make- up-removing creams, foundation creams or sun creams), liquid foundations, make-up- removing milks, protective or care body milks, sun milks, lotions, gels or foams for caring for the skin, such as cleansing lotions, sun lotions, artificial tanning lotions, bath compositions, deodorizing compositions comprising a bactericidal agent, aftershave gels or lotions, depilatory creams, compositions for countering insect stings or bites, pain-relieving compositions or compositions for treating one or more of aging, sun damaged, oily and acne prone skin, and certain skin diseases, such as eczema, rosacea, psoriasis, lichen and severe pruritus.
  • skin diseases such as eczema, rosacea
  • the water and or the glycols in the compositions typically form part or all of a cosmetically acceptable carrier.
  • the cosmetically acceptable carrier can include, for example, glycerin, C1-4 alcohols, organic solvents, fatty alcohols, fatty ethers, fatty esters, polyols, glycols, vegetable oils, mineral oils, liposomes, laminar lipid materials, water, or any combinations thereof.
  • organic solvents non-limiting mentions can be made of monoalcohols and polyols such as ethyl alcohol, isopropyl alcohol, propyl alcohol, benzyl alcohol, and phenylethyl alcohol, or glycols or glycol ethers such as, for example, monomethyl, monoethyl and monobutyl ethers of ethylene glycol, propylene glycol or ethers thereof such as, for example, monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol as well as alkyl ethers of diethylene glycol, for example monoethyl ether or monobutyl ether of diethylene glycol.
  • organic solvents are ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propane diol, and glycerin.
  • the organic solvents can be volatile or non-volatile compounds.
  • cosmetically acceptable carriers may comprise water, a mixture of water and at least one cosmetically acceptable organic solvent, or at least one cosmetically acceptable organic solvent. Additionally, cosmetically acceptable carriers may be or may include ethanol, a glycol ether, for example, dipropylene glycol n-butyl ether, isododecane, mineral oil, propylene glycol, pentylene glycol, hexylene glycol, glycerol, and mixtures thereof.
  • a glycol ether for example, dipropylene glycol n-butyl ether, isododecane, mineral oil, propylene glycol, pentylene glycol, hexylene glycol, glycerol, and mixtures thereof.
  • water is present in the compositions in a range from about 35% to about 90%, and in some embodiments, from about 35% to about 70%, and in some embodiments, from about 35% to about 65%, and in some embodiments, from about 35% to about 60%, and in some embodiments, about 68% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • water is present in the compositions in a range from about 35% to about 90%, and in some embodiments, from about 35% to about 70%, and in some embodiments, from about 35% to about 65%, and in some embodiments, from about 35% to about 60%, and in some embodiments, about 68% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • ranges are within the scope of the invention.
  • water is present, by weight, based on the total weight of the composition, from about 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, to about 90 percent, by weight, including increments and ranges therein and there between.
  • ranges are within the scope of the invention.
  • the water used may be sterile demineralized water and/or a floral water such as rose water, cornflower water, chamomile water or lime water, and/or a natural thermal or mineral water such as, for example: water from Vittel, water from the Vichy basin, water from Uriage, water from La Roche Posay, water from La Bourboule, water from Enghien-les-Bains, water from Saint Gervais-les-Bains, water from Neris-les-Bains, water from Allevar-les-Bains, water from Digne, water from Maizieres, water from Neyrac-les-Bains, water from Lons-le-Saunier, water from Eaux Bonnes, water from Rochefort, water from Saint Christau, water from Les Fumades, water from Tercis-les- Bains or water from Avene.
  • the water phase may also comprise reconstituted thermal water, that is to say a water comprising trace elements such as zinc, copper, magnesium, etc., reconstituting the characteristics of a thermal
  • the pH of the composition is not limited but is generally between about 2.0 and about 7.0, and in some embodiments, is one of between about 3 and about 4.5.
  • the pH can be adjusted to the desired value by addition of a base (organic or inorganic) to the composition, for example, sodium citrate, ammonia or a primary, secondary or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1 ,3-propanediamine, or alternatively by addition of an inorganic or organic acid, advantageously a carboxylic acid, such as, for example, citric acid.
  • a base organic or inorganic
  • a primary, secondary or tertiary (poly)amine such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1 ,3-propanediamine
  • an inorganic or organic acid advantageously a carboxylic acid, such as, for example, citric acid.
  • the pH of the composition is not limited but is generally not less than 3.5.
  • the pH can be adjusted to the desired value by addition of a base (organic or inorganic) to the composition, for example ammonia or a primary, secondary or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1,3- propanediamine, sodium hydroxide, potassium hydroxide or alternatively by addition of an inorganic or organic acid, advantageously a carboxylic acid, such as, for example, citric acid.
  • a base organic or inorganic
  • a primary, secondary or tertiary (poly)amine such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1,3- propanediamine
  • sodium hydroxide sodium hydroxide
  • potassium hydroxide potassium hydroxide
  • an inorganic or organic acid advantageously a carboxylic acid, such as, for example, citric acid.
  • the composition includes one or more solvents comprising alcohol for solubilizing acid, for example, monoalcohols such as monohydric C1-C8 alcohols such as ethanol, propanol, butanol, isopropanol, isobutanol, and benzyl alcohol, and phenylethyl alcohol.
  • the alcohol solvent is selected from one or a combination of ethanol and isopropyl alcohol.
  • the solvents may also include water-soluble solvents including polyols and short chain mono-alcohols.
  • the water-soluble solvents are selected from glycerin, propylene glycol, butylene glycol, and combinations thereof.
  • a solvent used in accordance with the disclosure is propylene glycol.
  • the amount of alcohol or glycol present in the composition is in the range from about 5% to about 20%, or from about 6% to about 18%, or from about 10% to about 15%, or any suitable combination, sub combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • the amount of alcohol or glycol present in the composition is in the range from about 5% to about 20%, or from about 6% to about 18%, or from about 10% to about 15%, or any suitable combination, sub combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • any one of or a combination of alcohols or glycols may be present, by weight, based on the total weight of the composition, from about 5, 6, 7, 8, 9, 10, 11 , 12, 13, 14, 15, 16, 17, 18, 19, to about 20 weight percent, including increments and ranges therein and there between.
  • compositions can also contain one or more antioxidants.
  • Antioxidants can be any antioxidant or other additive suitable for use in cosmetic formulations. Suitable additives include, but are not limited to, resveratrol, tannic acid, polyphenols, amino acids and derivatives thereof, imidazoles, peptides such as carnosine and derivatives, carotenoids, carotenes (such as a-carotene, b-carotene, and lycopene), additional acids selected from a-hydroxy acids (such as citric acid, lactic acid, malic acid, and combinations of these), beta-hydroxy acids (such as propionic acid, beta-hydroybutyric acid, beta-hydroxy beata-methylbutyric acid, carnitine, and combinations of these), tocopherols and derivatives (such as Vitamin E), vitamin A, co-enzyme Q10, bioflavonoids, glutathione, plant extracts (such as rosemary extract, olive leaf extracts, Scutellaria Baicalensis (baical
  • the composition may include optional additives selected chosen from terephthalylidene dicamphor sulfonic acid, trisodium ethylenediamine disuccinate, sodium citrate, sodium chloride, hydroxyacetophenone sodium benzoate, potassium sorbate, citric acid, caprylyl glycol, and trisodium ethylenediamine disuccinate, and combinations thereof.
  • the amount of one or more actives and additives, alone or in combination, when present in the composition according to the disclosure can be present in a range from about 0.001% to about 20%, and in some embodiments, from about 0.05% to about 0.01%, and in some embodiments, from about 0.01% to about 0.1%, and in some embodiments, from about 0.15% to about 5%, and in some embodiments, from about 0.40% to about 4%, and in some embodiments, from about 0.5% to about 2.5%, and in some embodiments, from about 0.1% to about 0.5% and in some embodiments, from about 1% to about 2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the total weight of the composition.
  • One of ordinary skill in the art will appreciate that other ranges are within the scope of the invention.
  • compositions were evaluated for stability and Microbial Challenge Tests.
  • the Challenge test protocol similar to the PCPC guidelines was followed to assess efficacy against a broad spectrum of microorganisms.
  • transition metal 2+ ions such as copper and zinc to provide additional microbial preservation against gram-positive bacteria were tested.
  • copper gluconate was added to the composition, a blue-green tint was observed. Such color was undesirable for the formulation.
  • transition metal 2+ ion i.e. zinc
  • Zinc salts are typically used for their anti-acneic and anti-seborrhea properties. These properties inspired trials with the inclusion of zinc gluconate and zinc pea by the formulation needing additional strength for gram-positive bacteria since bacteria are common causes for acne.
  • Gluconates also are beneficial for hydration by being skin-conditioning agents, which led to focus on zinc gluconate as an additive for preservation for the instant disclosure.
  • the goal of the instant disclosure was to provide a preservation for non- protective packaging, such as a jar, for highly natural formulas without using alcohol or petrochemical-based preservatives and provides a stable formulation for a highly sensitive composition.
  • Table 2 continue Stable compositions were validated by Inv. Ex. 1, Inv. Ex. 2, Inv. Ex. 3 and Inv. Ex.4. These compositions contained the preservative system mentioned in the instant disclosure. These Inventive Examples passed the microbiological tests as it is shown in Table 2.
  • Comp. Ex. 1 , Comp. Ex. 2, Comp. Ex. 3 and Comp. Ex 4 were prepared similarly to the inventive examples except that one or two of the ingredients of the preservative systems were not present. It was observed that if only salicylic acid and benzoic acid were present, the microbiological tests failed (i.e. Comp. Ex. 2, Comp. Ex. 3 and Comp. Ex.4). In the case of Comp. Ex. 1 where the preservative system contained salicylic acid and copper gluconate, the microbiological test was borderline and consequently not acceptable.
  • the preservative system of the composition contained 0.1% of Salicylic Acid and 0.15% of benzoic acid with 3.5% of alcohol denatured, despite a good microbiological test, the composition was not stable and a separation of the emulsion was observed.
  • chlorphenesin a known non-natural preservative
  • the use of this material was undesirable due to the formulation's high natural content and the loss of mousse-like texture and glossy surface appearance after 2 weeks in stability.
  • Chlorphenesin is also a petrochemical-derived preservative which was undesirable for the formula.
  • the inventive examples demonstrated the microbial preservation against gram-positive bacteria of the preservative system constituted by the association of salicylic acid, benzoic acid and transition metal 2+ ions such as copper and zinc.
  • At least one means one or more and thus includes individual components as well as mixtures/combinations.
  • free and “devoid” indicates that no reliably measurable excluded material is present in the composition, typically 0% by weight, based on the total weight of the composition.
  • essentially free means that, while it prefers that no excluded material is present in the composition, it is possible to have very small amounts of the excluded material in the composition of the invention, provided that these amounts do not materially affect the advantageous properties of the composition.
  • essentially free means that excluded material can be present in the composition at an amount of less than about 0.1% by weight, based on the total weight of the composition.
  • weight or amount as used herein with respect to the percent amount of an ingredient refers to the amount of the raw material comprising the ingredient, wherein the raw material may be described herein to comprise less than and up to 100% activity of the ingredient. Therefore, weight percent of an active in a composition is represented as the amount of raw material containing the active that is used, and may or may not reflect the final percentage of the active, wherein the final percentage of the active is dependent on the weight percent of active in the raw material.
  • weight percent and “wt%” may be used interchangeably and mean percent by weight, based on the total weight of a composition, article or material, except as may be specified with respect to, for example, a phase, or a system that is a component of a composition, article or material. All ranges and amounts given herein are intended to include subranges and amounts using any disclosed point as an end point. Thus, a range of “1% to 10%, such as 2% to 8%, such as 3% to 5%,” is intended to encompass ranges of “1% to 8%,” “1% to 5%,” “2% to 10%,” and so on. All numbers, amounts, ranges, etc., are intended to be modified by the term “about,” whether or not so expressly stated.

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Abstract

L'invention concerne un système conservateur qui comprend de l'acide salicylique ; un acide organique faible ou ses sels ; et un ou plusieurs sels de métaux de transition divalents ; et des compositions cosmétiques formulées avec les systèmes conservateurs.
PCT/US2022/017624 2021-03-31 2022-02-24 Nouveau système conservateur, et composition cosmétique le comprenant WO2022211933A1 (fr)

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CN202280023038.3A CN117062592A (zh) 2021-03-31 2022-02-24 新的防腐剂体系和包含它的化妆品组合物
EP22708706.1A EP4312958A1 (fr) 2021-03-31 2022-02-24 Nouveau système conservateur, et composition cosmétique le comprenant
JP2023559793A JP2024512996A (ja) 2021-03-31 2022-02-24 新しい防腐系、及びそれを含む化粧用組成物
KR1020237033747A KR20230154923A (ko) 2021-03-31 2022-02-24 새로운 방부제 시스템, 및 이를 포함하는 화장료 조성물

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US17/218,797 US20220313575A1 (en) 2021-03-31 2021-03-31 Preservative system
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FR2107903A FR3125415B1 (fr) 2021-07-22 2021-07-22 Nouveau système de conservation
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Publication number Priority date Publication date Assignee Title
AT396897B (de) * 1990-12-21 1993-12-27 Haltmeier Georg Mittel zum imprägnieren von holz
WO2000005954A1 (fr) * 1998-07-30 2000-02-10 Stoller Enterprises, Inc. Traitement de plantes au moyen d'acide salicylique et d'amines organiques
US6294186B1 (en) * 1997-06-04 2001-09-25 Peter William Beerse Antimicrobial compositions comprising a benzoic acid analog and a metal salt
US20050281762A1 (en) * 2002-02-07 2005-12-22 Modak Shanta M Zinc salt compositions for the prevention of dermal and mucosal irritation
US20080253972A1 (en) * 2006-09-19 2008-10-16 Prud Homme Estelle Aqueous/alcoholic deodorant composition comprising a water-soluble zinc salt and salicylic acid
CN101972270A (zh) * 2010-11-09 2011-02-16 石家庄乐足科技有限公司 一种防治脚气的外用粉剂
CN103191785A (zh) * 2013-03-06 2013-07-10 南京工程学院 一种节能增效湿法脱硫催化剂及其使用
US20170239155A1 (en) * 2016-02-19 2017-08-24 Colgate-Palmolive Company Personal care compositions
WO2019226921A1 (fr) * 2018-05-23 2019-11-28 The Trustees Of Columbia University In The City Of New York Produits de soin buccodentaire d'origine végétale sans alcool

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT396897B (de) * 1990-12-21 1993-12-27 Haltmeier Georg Mittel zum imprägnieren von holz
US6294186B1 (en) * 1997-06-04 2001-09-25 Peter William Beerse Antimicrobial compositions comprising a benzoic acid analog and a metal salt
WO2000005954A1 (fr) * 1998-07-30 2000-02-10 Stoller Enterprises, Inc. Traitement de plantes au moyen d'acide salicylique et d'amines organiques
US20050281762A1 (en) * 2002-02-07 2005-12-22 Modak Shanta M Zinc salt compositions for the prevention of dermal and mucosal irritation
US20080253972A1 (en) * 2006-09-19 2008-10-16 Prud Homme Estelle Aqueous/alcoholic deodorant composition comprising a water-soluble zinc salt and salicylic acid
CN101972270A (zh) * 2010-11-09 2011-02-16 石家庄乐足科技有限公司 一种防治脚气的外用粉剂
CN103191785A (zh) * 2013-03-06 2013-07-10 南京工程学院 一种节能增效湿法脱硫催化剂及其使用
US20170239155A1 (en) * 2016-02-19 2017-08-24 Colgate-Palmolive Company Personal care compositions
WO2019226921A1 (fr) * 2018-05-23 2019-11-28 The Trustees Of Columbia University In The City Of New York Produits de soin buccodentaire d'origine végétale sans alcool

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