WO2022130292A1 - Composition cosmétique capturant des métaux - Google Patents

Composition cosmétique capturant des métaux Download PDF

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Publication number
WO2022130292A1
WO2022130292A1 PCT/IB2021/061877 IB2021061877W WO2022130292A1 WO 2022130292 A1 WO2022130292 A1 WO 2022130292A1 IB 2021061877 W IB2021061877 W IB 2021061877W WO 2022130292 A1 WO2022130292 A1 WO 2022130292A1
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WIPO (PCT)
Prior art keywords
cosmetic composition
acid
glycol
combination
weight
Prior art date
Application number
PCT/IB2021/061877
Other languages
English (en)
Inventor
Nicholas David Stebbins
Patricia Brieva
Susan CHIRCH-HALPERN
Stephen Matthew Lynch
Rabije CEKOVIC
Original Assignee
L'oreal
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Filing date
Publication date
Priority claimed from US17/125,945 external-priority patent/US20220202671A1/en
Priority claimed from FR2100579A external-priority patent/FR3118874B1/fr
Application filed by L'oreal filed Critical L'oreal
Priority to CN202180083873.1A priority Critical patent/CN116634991A/zh
Priority to EP21830790.8A priority patent/EP4262707A1/fr
Priority to KR1020237023606A priority patent/KR20230114314A/ko
Publication of WO2022130292A1 publication Critical patent/WO2022130292A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/51—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Definitions

  • This invention relates to a cosmetic composition for keratinous tissue, particularly skin, that includes a metal chelation system in a water-based carrier, that demonstrates highly efficient metal chelation/sequestering effective to minimize free radical formation.
  • UV exposure and environmental pollution can accelerate skin aging by producing free radicals in skin.
  • Antioxidants including Vitamin C, and other actives protect cells from the damage of oxidative stress by scavenging free radicals and inhibiting oxidation reactions.
  • the topical application of antioxidants and other skin actives is broadly employed in skin care products to prevent skin aging.
  • Antioxidants are known to exhibit chemical properties that are associated with reduced tissue damage.
  • Antioxidants are known to participate in sequestering chemically active species to prevent the formation of free radicals which can contribute to oxidative stress leading to aging of skin.
  • the disclosure relates to an antioxidant system and a cosmetic composition comprising the antioxidant system that that demonstrates high efficiency in sequestering metal ions.
  • the antioxidant system includes a combination of vitamin C, ferulic acid, and phytic acid combined in a water based system.
  • the disclosure provides a cosmetic composition comprising:
  • a metal chelation system comprising: i. ferulic acid; and ii. phytic acid;
  • the cosmetic composition demonstrates one or both metal chelation and metal oxidation of at least one species of metal ions.
  • the metal ions that are chelated or oxidized are selected from the group consisting of iron and copper.
  • the cosmetic composition demonstrates one or both metal chelation and metal oxidation of one or a combination of metal ions.
  • the cosmetic composition demonstrates metal chelation or metal oxidation of iron and copper, each characterized by removal of free metal ions in material contacted with the cosmetic composition, the removal of free metal ions in a range from at least about 40% and up to about 99% removal of metal ions.
  • the cosmetic composition is formed by providing the carrier system having a water-phase that comprises water.
  • the carrier system may further comprise one more additional ingredients, each present in the water phase or in another phase, such as an oily phase.
  • the one or more additional ingredients includes one or more of a glycol, a humectant, a preservative, a surfactant, a thickener, an active compound, or a combination thereof.
  • the cosmetic composition may include one or more of any one of the additional ingredients.
  • the cosmetic composition may also include emulsifiers, emollients, fragrances, pH adjusters, other cosmetically acceptable additives, or a combination thereof.
  • the cosmetic composition may be any suitable form, such as, but not limited to, a single phase solution comprising the water phase, a multi-phase solution comprising at least one water phase, an emulsion comprising a water phase, such as, but not limited to, a water-in-oil emulsion, an oil-in-water emulsion, or a silicone-in-water emulsion.
  • the cosmetic composition may be provided in a product form for application to keratinous tissue, such as, but not limited to, a skin care product or a hair care product, and may be a product form such as, but not limited to, a hydroglycolic solution, a micellar water, a cream or lotion, a toner, a cleanser, or a make-up remover.
  • a product form such as, but not limited to, a hydroglycolic solution, a micellar water, a cream or lotion, a toner, a cleanser, or a make-up remover.
  • the cosmetic composition in any of the product forms may be either a leave-on or a rinse-off formulation.
  • the ascorbic acid is present in the cosmetic composition in a range from about 5% to about 30%, by weight, based on the weight of the composition, the ascorbic acid present in a ratio of water to ascorbic acid in a range from about 3:1 to about 10:1 , based on the weight of the cosmetic composition.
  • the ferulic acid is present in the cosmetic composition in a range from about 0.2% to about 5%, by weight, based on the weight of the composition.
  • the cosmetic composition comprises phytic acid present in the cosmetic composition in a range from about 0.25% to about 10%, by weight, based on the weight of the composition.
  • the disclosure provides a cosmetic composition comprising:
  • a metal chelation system comprising: i. ferulic acid; and ii. phytic acid, chlorogenic acid or a combination thereof;
  • a carrier system comprising a water phase.
  • a cosmetic composition comprising:
  • a metal chelation system comprising: i. ferulic acid; and ii. phytic acid;
  • a carrier system comprising: a water phase, and one or more additional components comprising a glycol, a humectant, a preservative, a surfactant, a thickener, an active compound, an emulsifier, an emollient, or a combination thereof.
  • the disclosure provides a cosmetic composition comprising:
  • a metal chelation system comprising: i. ferulic acid present in a range from about 0.2% to about 5%; ii. phytic acid present in a range from about 0.25% to about 10%;
  • a carrier system comprising a water phase; all amounts by weight, based on the weight of the composition.
  • the cosmetic composition comprises one or a combination of active compounds selected from the group consisting of Vitamin E, carnosine, hyaluronic acid, panthenol, at least one sun filter, at least one hydroxy acid, and combinations thereof.
  • an active compound is selected from the group consisting of alpha, beta or polyhydroxy acids selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose, and combinations thereof.
  • the cosmetic composition is formed by providing the carrier system having a water-phase that comprises water and a glycol or combination of glycols selected from the group consisting of: dipropylene glycol, pentylene glycol, hexylene glycol, ethoxydiglycol, a combination of dipropylene glycol and pentylene glycol, and a combination of dipropylene glycol and hexylene glycol.
  • the cosmetic composition comprises water in a range from about 40% up to about 75%, based on the weight of the cosmetic composition.
  • the cosmetic composition further includes one or more additives selected from emulsifiers, emollients, fragrances, pH adjusters, and other cosmetically acceptable additives, or a combination thereof, and is free or essentially free of powders and solid particles, including but not limited to, titanium dioxide, zinc oxide, tin oxide, iron oxides, mica, silica, ferric ferrocyanide, alumina, silicates, synthetic fluorphlogopite, polyethylene, polypropylene, poly methyl methacrylate, talc, perlites, hectorites, bentonite, kaolin, pumice, boron nitride, and combinations thereof.
  • the cosmetic composition excludes propylene glycol or butylene glycol.
  • Cosmetically acceptable means a carrier that is compatible with any keratinous substrate.
  • the cosmetic composition includes a metal chelation system comprising the combination of ascorbic acid, ferulic acid and phytic acid in a carrier system that includes water, and further includes one or more other ingredients for providing one of a variety of forms of cosmetic products, the ingredients including but not limited to a glycol, a humectant, a preservative, a surfactant, a thickener, an active compound, or a combination thereof.
  • the cosmetic composition may also include emulsifiers, emollients, fragrances, pH adjusters, other cosmetically acceptable additives, or a combination thereof.
  • the cosmetic composition may include one or more of any one of the additional ingredients.
  • the cosmetic composition may include one, or more than one glycol, or one, or more than one humectant, and the like. It will be understood that additional ingredients, when present, are present in the carrier system in either a water phase or an oily phase.
  • the cosmetic composition may be any suitable cosmetic composition, such as, but not limited to, a single phase solution comprising the water phase, a multi-phase solution comprising at least one water phase, an emulsion comprising a water phase, such as, but not limited to, a water-in-oil emulsion, an oil-in-water emulsion, or a silicone- in-water emulsion.
  • a single phase solution comprising the water phase
  • a multi-phase solution comprising at least one water phase
  • an emulsion comprising a water phase such as, but not limited to, a water-in-oil emulsion, an oil-in-water emulsion, or a silicone- in-water emulsion.
  • the cosmetic composition may be provided in a product form for application to keratinous tissue, such as, but not limited to, a skin care product or a hair care product, and may be a product form such as, but not limited to, a hydroglycolic solution, a micellar water, a cream or lotion, a toner, a cleanser, or a make-up remover.
  • a product form such as, but not limited to, a hydroglycolic solution, a micellar water, a cream or lotion, a toner, a cleanser, or a make-up remover.
  • the cosmetic composition in any of the product forms may be either a leave-on or a rinse-off formulation.
  • the cosmetic composition according to the disclosure is a single phase solution that comprises one or more solutes dissolved in one or more solvents to form a substantially homogeneous liquid that appears to be substantially clear to the naked eye.
  • the cosmetic composition is a single phase water solution.
  • the cosmetic composition is a hydroglycolic solution that comprises one or a combination of glycols
  • the inventors have shown the surprising and unexpected effect of the combination of ascorbic acid, ferulic acid and phytic acid as a potent metal chelator/sequester.
  • the ability to chelate different metal ions such as iron and copper was increased in representative cosmetic composition comprising a hydroglycolic solution.
  • the combination of ascorbic acid, ferulic acid and phytic acid demonstrated to the most chelation versus any other combination.
  • the level of copper and iron (II) was kept to a minimum in the cosmetic composition to diminish or eliminate oxidative reacting catalysis by the metal ions and thereby minimize oxidative stress in treated keratinous tissue.
  • the cosmetic composition demonstrates one or both metal chelation and metal oxidation of at least one species of metal ions. In some embodiments the cosmetic composition demonstrates one or both metal chelation and metal oxidation of one or a combination of metal ions. In some particular embodiments, the cosmetic composition demonstrates metal chelation or metal oxidation of iron and copper, each characterized by removal of free metal ions in material, for example a fluid or a keratinous substrate, contacted with the cosmetic composition, the removal of free metal ions in a range from at least about 40% and up to about 99% removal of metal ions.
  • embodiments of the cosmetic composition include a metal chelation system comprising a combination of ferulic acid, and phytic acid.
  • the chelation system comprises ferulic acid and one or both of phytic acid and chlorogenic acid.
  • the cosmetic composition includes in the chelation system each of ferulic acid and phytic acid.
  • the cosmetic composition comprises each of ascorbic acid, ferulic acid, and phytic acid.
  • the cosmetic composition may include ascorbic acid (Vitamin C).
  • pH of the cosmetic composition in the range from about 3.0 to about 4.0, and more particularly about 3.5 ensures that greater than about 82% of the ascorbic acid remains in a protonated, uncharged form as disclosed in U.S. Pat. No. 5,140,043, Aug. 18, 1992, the entire disclosure of which is incorporated by reference herein.
  • Ascorbic acid may be provided by the addition of any reducing analog of ascorbic acid, such as D-isoascorbic acid or by the addition of other small reducing compounds such as, but not limited to, glutathione, L-cysteamine, and the like. Such forms would be expected to provide an equivalent composition to that claimed and are within the scope of the invention.
  • the cosmetic composition comprises ferulic acid, which is a cinnamic acid derivative.
  • a cinnamic acid or derivative thereof includes ferulic acid, p-coumaric acid, caffeic acid, sinapinic acid, chlorogenic acids, caftaric acid, chicoric acid, coutaric acid, rosmarinic acid, derivatives thereof, and combinations thereof.
  • Equivalent derivatives thereof include those cinnamic acid derivatives having substitutions on the hydroxyl groups of the aromatic ring such as short chain aliphatic groups (one to six carbon atoms) or long chain aliphatic groups (seven to twenty-four carbon atoms) to form an ether, or such aliphatic groups substituted with alkyl, alkoxy, hydroxyl, amino, or amido, for example, to form a substituted ether.
  • Equivalent derivatives thereof further include those cinnamic acid derivatives having modifications of the methoxy group(s) of the aromatic ring to short chain aliphatic groups (two to six carbon atoms) or to long chain aliphatic groups (seven to twenty-four carbon atoms) to form a longer chain ether, or such aliphatic groups substituted with alkyl, alkoxy, hydroxyl, amino, or amido, for example, to form a substituted long chain ether.
  • the 3- carboxy group of a cinnamic acid derivative may also be converted to esters or amides having aliphatic groups of up to 24 carbons or an aromatic group, for example.
  • Cis and trans isomers of the cinnamic acid derivatives are included herein since the cis isomer is readily converted to the trans isomer.
  • Salts of the cinnamic acid derivatives are included herein.
  • the cinnamic acid derivative is a triethanolamine salt.
  • Caffeic acid also known as 3-(3,4-dihydroxyphenyl)-2-propenoic acid, is found in many fruits, vegetables, seasonings and beverages consumed by humans. Caffeic acid is present in such goods in conjugated forms such as chlorogenic acid.
  • Para-coumaric acid also known as 3-(4-hydroxyphenyl)-2-propenoic acid or p-hydroxycinnamic acid
  • Trans-ferulic acid also known as 3-(4-hydroxy-3-methoxyp- henyl)-2-propenoic acid or 4-hydroxy-3-methoxycinnamic acid
  • Sinapinic acid also known as 3,5-dimethoxy4-hydroxycinnamic acid, is from black mustard seeds.
  • Caffeic acid, para- coumaric acid, trans-ferulic acid and sinapinic acid are commercially available from Sigma-Aldrich.
  • the cosmetic composition comprise at least one or a combination of phytic acid and chlorogenic acid.
  • the cosmetic composition comprise phytic acid.
  • Phytic acid is also known as phytate and is a six-fold dihydrogenphosphate ester of inositol (specifically, of the myo isomer), also called inositol hexakisphosphate (IP6) or inositol polyphosphate.
  • IP6 inositol hexakisphosphate
  • the phosphates are partially ionized, resulting in the phytate anion.
  • Phytic acid is found naturally in plant seeds and is a storage form of phosphorus.
  • the cosmetic composition comprise chlorogenic acid.
  • Chlorogenic acid is also known as chlorogenate or 3-caffeoylquinate and belongs to the class of organic compounds known as quinic acids and derivatives. Chlorogenic acid is the ester of caffeic acid (a hydroxycinnamic acid related to ferulic acid, as described herein above) and (-)-quinic acid.
  • composition further includes ascorbic acid.
  • each skin active in the at least one or a combination of skin actives comprising at least one or a combination of ascorbic acid, a cinnamic acid derivative, and Vitamin E, the combination present in the cosmetic composition at a concentration, from about 15% to about 30%, and in some embodiments, from about 16% to about 30%, and in some embodiments, from about 16% to about 25%, and in some embodiments, from about 16.5% to about 24%, or any suitable combination, subcombination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • Cinnamic acid derivatives including, but not limited to ferulic acid, and triethanolamine salts may be present in the cosmetic compositions in an amount from about 0.1 % to about 5%, and in some embodiments, from about 0.1 % to about 3%, and in some embodiments, from about 0.5% to about 1 .0%, or any suitable combination, sub- combination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • Phytic acid may be present in the cosmetic compositions in an amount from about 0.5% to about 5%, and in some embodiments, from about 1 % to about 4%, and in some embodiments, from about 1 % to about 2%, or any suitable combination, subcombination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • the phytic acid raw material is provided at a dilution of 50% such that the exemplified weight percents in the cosmetic compositions are multiplied by 0.5 to obtain the final weight percent of phytic acid.
  • Chlorogenic acid may be present in the cosmetic compositions in an amount from about 0.5% to about 1.5%, and in some embodiments, from about 1 % to about 1.5%, and in some embodiments, from about 1.1 % to about 1.2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • Ascorbic acid and its derivatives may be present in the cosmetic composition in an amount from about 1 % to about 30%, and in some embodiments, from about 5% to about 25%, and in some embodiments, from about 10% to about 20%, and in some embodiments, from about 10% to about 15%, or any suitable combination, subcombination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • Phytic acid, carnosine, chlorogenic acid, hyaluronic acid, panthenol may be present in the cosmetic composition in an amount from about 0.1 % to about 5%, and in some embodiments, from about 0.1 % to about 3%, and in some embodiments, from about 0.5% to about 1 .0%, or any suitable combination, sub-combination, range, or subrange thereof by weight, based on the weight of the cosmetic composition.
  • each of the components of the metal chelation system and optionally ascorbic acid is present in a composition according to the disclosure, and each of the individual components in the ranges as described herein above, from about 0.01 , 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 , 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 , 22, 23, 24, 25, 26, 27, 28 to about 30 percent by weight, including increments and ranges there between.
  • the cosmetic composition demonstrates one or both metal chelation and metal oxidation of at least one species of metal ions.
  • the metal ions that are chelated or oxidized are selected from the group consisting of iron and copper.
  • the cosmetic composition demonstrates one or both metal chelation and metal oxidation of one or a combination of metal ions.
  • the cosmetic composition demonstrates metal chelation or metal oxidation of iron and copper, each characterized by removal of free metal ions in material contacted with the cosmetic composition, the removal of free metal ions in a range from at least about 40% and up to about 99% removal of metal ions.
  • an antioxidant solution of either ferulic acid or phytic acid, to which metal is added in a ratio of 1 : 1 and 1 :10, metal to antioxidant provides a removal of metal ions characterized by clustering/removal of free metal ions.
  • phytic acid helps diminish free radicals in a fluid or on a keratinous substrate by chelating metal, particularly iron ions
  • ferulic acid help helps diminish free radicals in a fluid or on a keratinous substrate by chelating metal, particularly copper ions.
  • phytic acid chelates/removes metal, particularly iron, to thereby diminish the amount of iron ions by about 60%, and by about 80%, thereby leaving residual iron of about 20% and about 40% in respective examples.
  • ferulic acid chelates/removes metal, particularly copper, to thereby diminish the amount of copper ions by about 60% and by about 90%, thereby leaving residual copper in in an amount of about 10% and about 40% in respective examples.
  • the cosmetic composition comprising a metal chelation system demonstrates chelation or removal of one or a combination of metal ions in a fluid or on a keratinous substrate in a range from about 40% to about 99%, or from about 40% to about 90% or from about 40% to about 80%, or from about 80% to about 90%, or from about 40, 41 , 42, 43, 44, 45, 46, 47, 48, 49, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 to about 99 percent, including increments and ranges there between.
  • the cosmetic composition is formed by providing a carrier system having a water-phase that comprises water.
  • water is present in the cosmetic compositions in a range from about 10% to about 95%, and in some embodiments, from about 25% to about 80%, and in some embodiments, from about 40% to about 65%, and in some embodiments, from about 55% to about 60%, or any suitable combination, subcombination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • water is present in the cosmetic compositions in a range from about 40% to about 75%, and in some embodiments, from about 45% to about 70%, and in some embodiments, from about 50% to about 65%, and in some embodiments, from about 55% to about 60%, and in some embodiments, about 68% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • water is present in the cosmetic compositions in a range from about 40% to about 75%, and in some embodiments, from about 45% to about 70%, and in some embodiments, from about 50% to about 65%, and in some embodiments, from about 55% to about 60%, and in some embodiments, about 68% or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • water is present, by weight, based on the total weight of the cosmetic composition, from about 40, 41 , 42, 43, 44,45, 46, 47, 48, 49, 50, 51 , 52, 53, 54, 55, 56, 57, 58, 59, 60, 61 , 62, 63, 64, 65, 66, 67, 68, 69, 70, 71 , 72, 73, to about 75 percent, by weight, including increments and ranges therein and there between.
  • One of ordinary skill in the art will appreciate that other ranges are within the scope of the invention.
  • the water used may be chosen from, for example, sterile demineralized water and/or a floral water such as rose water, cornflower water, chamomile water or lime water, and/or a natural thermal or mineral water such as, for example: water from Vittel, water from the Vichy basin, water from Uriage, water from La Roche Posay, water from La Bourboule, water from Enghien-les-Bains, water from Saint Gervais-les-Bains, water from Neris-les-Bains, water from Allevar-les-Bains, water from Digne, water from Maizieres, water from Neyrac-les-Bains, water from Lons-le-Saunier, water from Eaux Bonnes, water from Rochefort, water from Saint Christau, water from Les Fumades, water from Tercis-les-Bains or water from Avene.
  • the water phase may also comprise reconstituted thermal water, that is to say a water comprising trace elements such as zinc, copper, magnesium, etc., reconstitu
  • the pH of the cosmetic composition is not limited but is generally between 3.0 and 4.0, and in some embodiments, is one of between 3 and 3.5.
  • the pH can be adjusted to the desired value by addition of a base (organic or inorganic) to the cosmetic composition, for example ammonia or a primary, secondary or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1 ,3- propanediamine, or alternatively by addition of an inorganic or organic acid, advantageously a carboxylic acid, such as, for example, citric acid.
  • a base organic or inorganic
  • a primary, secondary or tertiary (poly)amine such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1 ,3- propanediamine
  • an inorganic or organic acid advantageously a carboxylic acid, such as, for example, citric acid.
  • pH is a measurement of the hydrogen ion concentration in water which is determined by measuring the electrode potential using electrodes attached to a pH meter. It will be further understood that, due to the intrinsic variability in pH measurements, a skilled artisan would expect at least a 10% variability in pH measurements of compositions such as disclosed herein when measured in a typical laboratory by a typical skilled person using a typical pH meter.
  • the cosmetic composition also comprises one more additional ingredients, such as, but not limited to, a glycol, a humectant, a preservative, a surfactant, a thickener, an active compound, or a combination thereof.
  • additional ingredients such as, but not limited to, a glycol, a humectant, a preservative, a surfactant, a thickener, an active compound, or a combination thereof.
  • the cosmetic composition may include one or more of any one of the additional ingredients.
  • the cosmetic composition may include one, or more than one glycol, or one, or more than one humectant, and the like. It will be understood that additional ingredients, when present, are present in the carrier system in either a water phase or an oily phase.
  • the cosmetic composition may be any suitable cosmetic composition, such as, but not limited to, a single phase solution comprising the water phase, a multi-phase solution comprising at least one water phase, an emulsion comprising a water phase, such as, but not limited to, a water-in-oil emulsion, an oil-in-water emulsion, or a silicone- in-water emulsion.
  • a single phase solution comprising the water phase
  • a multi-phase solution comprising at least one water phase
  • an emulsion comprising a water phase such as, but not limited to, a water-in-oil emulsion, an oil-in-water emulsion, or a silicone- in-water emulsion.
  • the cosmetic composition may be provided in a product form for application to keratinous tissue, such as, but not limited to, a skin care product or a hair care product, and may be a product form such as, but not limited to, a hydroglycolic solution, a micellar water, a leave-on cream or lotion, a toner, a cleanser, or a make-up remover.
  • keratinous tissue such as, but not limited to, a skin care product or a hair care product
  • a product form such as, but not limited to, a hydroglycolic solution, a micellar water, a leave-on cream or lotion, a toner, a cleanser, or a make-up remover.
  • the cosmetic composition comprises one or a combination of active compounds selected from the group consisting of Vitamin E, carnosine, hyaluronic acid, panthenol, at least one sun filter, at least one hydroxy acid, and combinations thereof.
  • an active compound is selected from the group consisting of alpha, beta or polyhydroxy acids selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose, and combinations thereof.
  • the cosmetic composition further includes one or more additives selected from emulsifiers, emollients, fragrances, pH adjusters, other cosmetically acceptable additives, or a combination thereof, and is free or essentially free of powders and solid particles, including but not limited to, titanium dioxide, zinc oxide, tin oxide, iron oxides, mica, silica, ferric ferrocyanide, alumina, silicates, synthetic fluorphlogopite, polyethylene, polypropylene, poly methyl methacrylate, talc, perlites, hectorites, bentonite, kaolin, pumice, boron nitride, and combinations thereof.
  • the cosmetic composition excludes propylene glycol or butylene glycol.
  • the humectant may comprise one or more of polyols, including, for example, hexylene glycol, dipropylene glycol, glycerin, glycerol, glycols, such as, caprylyl glycol, butylene glycol, propylene glycol, isoprene glycol, polyethylene glycol, monoethylene glycol, diethylene glycol, triethylene glycol, diethylene glycol, hexylene glycol, glycol ethers, such as, monopropylene, dipropylene and tripropylene glycol alkyl(C1 -C4)ethers, squalane, triacetin, sugars, such as, glucose, xylitol, maltitol, sorbitol, sucrose pentaerythritol, inositol, pyrrolidone carboxy
  • polyols including, for example, hexylene glycol, dipropylene glycol, glycerin, glyce
  • glycols when present, may be present in the cosmetic composition alone or with at least one other glycol, each glycol present in an amount that is in a range from about 0.1 % to about 30%, or from about 5% to about 25%, or from about 10% to about 15%, or any suitable combination, subcombination, range, or sub-range thereof by weight, based on the weight of the composition, by weight, based on the weight of the cosmetic composition.
  • the total amount of glycol is less than about 30%, for example, the total is about 29.5%, or about 29%.
  • some glycols when present alone in the cosmetic composition, are present in an amount that is at least about 8%, or at least about 8.5%, or at least about 9%, or at least about 9.5%, or at least about 10%, or at least about 10.5%.
  • each of the glycols is present in a cosmetic composition according to the disclosure, each alone and/or in combinations as described in the paragraphs set forth herein above from about 0.1 , 0.2, 0.3 ,0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.5, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 , 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 , 22, 23, 24, 25, 26, 27, 28, 29 to less than about 30 percent, by weight, including increments and ranges therein and there between.
  • the composition includes a glycol humectant selected from the group consisting of hexylene glycol, dipropylene glycol, pentylene glycol, propylene glycol, ethoxydiglycol, and combinations thereof.
  • the composition includes ethoxydiglycol, propylene glycol and pentylene glycol, or hexylene glycol, pentylene glycol and dipropylene glycol, or dipropylene glycol, or hexylene glycol and dipropylene glycol.
  • the composition includes glycerin.
  • the amount of humectant present in the cosmetic composition can range from about 1 % to about 10%, or from about 1 % to about 8%, or from about 1 % to about 5%, or from about 2% to about 3%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • the amount of humectant present in the cosmetic composition can range from about 1 % to about 10%, or from about 1 % to about 8%, or from about 1 % to about 5%, or from about 2% to about 3%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • any one of or a combination of humectant, when present, may be present, by weight, based on the total weight of the composition, is from about 1 , 2, 3, 4, 5, 6, 7, 8, 9, to about 10 percent, by weight, based on the weight of the cosmetic composition, including increments and ranges therein and there between.
  • one or more preservatives and/or antimicrobials may be present in the composition.
  • Any preservative commonly used in cosmetic formulations is an acceptable preservative for the cosmetic compositions herein, such as phenoxyethanol, members from the paraben family such as the methyl, ethyl, propyl, butyl or isobutyl parabens, 4-hydroxy benzoic acid, benzoic acid, sorbic acid, dehydroacetic acid, triclosan, benzyl alcohol, chlorophenesin, or salicylic acid, for example.
  • suitable solvents for optional additives in particular, suitable solvents for antimicrobials and preservatives, members from the paraben family may be used as a preservative.
  • the preservative may comprise one or more of preservatives selected from the group consisting of organic acids, parabens, formaldehyde donors, phenol derivatives, quaternary ammoniums, alcohols, isothiazolinones, and combinations thereof.
  • Preservatives having antibacterial activity are optionally present in the cosmetic compositions of the present invention.
  • organic acid preservatives include, but are not limited to, sodium benzoate, potassium sorbate, benzoic acid and dehydroacetic acid, sorbic acid, and combinations thereof.
  • a preferred organic acid preservative system includes a mixture of sodium benzoate and potassium sorbate.
  • paraben preservatives include, but are not limited to, alkyl para-hydroxybenzoates, wherein the alkyl radical has from 1 , 2, 3, 4, 5 or 6 carbon atoms and for example, from 1 to 4 carbon atoms e.g., methyl para-hydroxybenzoate (methylparaben), ethyl para-hydroxybenzoate (ethylparaben), propyl parahydroxybenzoate (propylparaben), butyl para-hydroxybenzoate (butylparaben) and isobutyl para-hydroxybenzoate (isobutylparaben).
  • alkyl para-hydroxybenzoates wherein the alkyl radical has from 1 , 2, 3, 4, 5 or 6 carbon atoms and for example, from 1 to 4 carbon atoms e.g., methyl para-hydroxybenzoate (methylparaben), ethyl para-hydroxybenzoate (ethylparaben), propyl parahydroxybenzoate (propylparaben
  • formaldehyde donor preservatives include, but are not limited to, 1 ,3-Dimethylol-5,5-dimethylhydantoin (DMDM hydantoin), imidazolidinyl urea, gluteraldehyde, and combinations thereof.
  • quaternary ammonium preservatives include, but are not limited to, benzalkonium chloride, methene ammonium chloride, benzethonium chloride, and combinations thereof.
  • alcohol preservatives include, but are not limited to, ethanol, benzyl alcohol, dichlorobenzyl alcohol, phenoxyethanol, and combinations thereof.
  • isothiazolone preservatives include, but are not limited to, methylchloroisothiazolinone, methylisothiazolinone, and combinations thereof.
  • Suitable preservatives include, but are not limited to, chloracetamide, triclosan and iodopropynyl butylcarbamate, pyridine derivatives (e.g., pyrithione and zinc pyrithione), chlorphenesin, phenyl mercuric salts, phenoxyethanol, and other known preservative systems.
  • the preservative includes one or more preservatives, the one or combination present at a concentration, by weight of about 0.001 % to about 5%, or alternatively about 0.05% to about 2.5% or alternatively about 0.1 % to about 2.0%, based upon weight of the composition.
  • any one of or a combination of preservatives, when present, may be present, by weight, based on the total weight of the composition, is from about 0.001 , 0.002, 0.003 ,0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01 , 0.02, 0.03 ,0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1 .0, 1 .1 , 1 .2, 1 .3, 1 .4, 1 .5, 1 .6, 1 .7, 1 .8, 1 .9, 2, 3, 4, to about 5 weight percent, including increments and ranges therein and there between.
  • various non-limiting embodiments of the cosmetic composition may optionally include at least one surfactant.
  • various non-limiting embodiments of the cosmetic composition that include an oil, for example, but not limited to, a Vitamin E component, such as tocopherol may optionally include at least one surfactant.
  • the cosmetic composition comprises no oil.
  • the cosmetic composition comprises no surfactant.
  • the cosmetic composition comprises at least one oil, for example, tocopherol, with at least one surfactant.
  • the cosmetic composition comprises at least one oil with more than one surfactant.
  • the cosmetic composition comprises at least one oil without any surfactants, wherein the total amount of oil present does not inhibit forming the cosmetic composition as a clear, single phase solution.
  • the at least one surfactant may be an nonionic, cationic, anionic, or a zwitterionic surfactant.
  • the at least one surfactant may be selected from the group consisting of polyoxyethylene sorbitan monolaureate, laureth-23, polyoxyethylated octyl phenol, 3-((3-cholamidopropyl) dimethylammonio)-1 propane sulfonate, sodium dilauramidoglutamide lysine, cholate, deoxycholate, sodium dodecylsulfate, TWEEN-80, and combinations thereof.
  • the at least one surfactant may exclude esters.
  • the at least one surfactant may be present in the cosmetic composition in a range from about 1 % to about 5%, based on the weight of the cosmetic composition.
  • the at least one surfactant when present, comprises one or a combination of polyoxyethylene sorbitan monolaureate and laureth- 23.
  • the at least one surfactant when present, may be present from about 1 % to about 5% by weight of the cosmetic composition, and in some embodiments, from about 1 % to about 2% , and in some embodiments, from about 3% to about 6%, and in some embodiments, from about 3% to about 4.5%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • laureth-23 may be present from about 1 % to about 5% by weight of the cosmetic composition, and in some embodiments, from about 3% to about 4.5%, or any suitable combination, subcombination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • polyoxyethylene sorbitan monolaureate may be present from about 1 % to about 5% by weight of the cosmetic composition, and in some embodiments, from about 1 % to about 2%, or any suitable combination, subcombination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • the cosmetic composition comprises more than one surfactant.
  • each of the at least one surfactant when present, may be present in a composition according to the disclosure from about 1 , 2, 3, 4, to about 5 percent, by weight, including increments and ranges therein and there between.
  • the composition may include one or more polymeric thickeners.
  • the one or more thickener may be selected from one or more of natural gums and synthetic polymers, for example, the thickener may be selected from the group consisting of starches (com, rice, tapioca, potato), gums (xanthan carrageenan, gellan, sclerotium, tarabiotech fermentation).
  • the thickener may be selected from acrylates/C 10-30 alkyl acrylate crosspolymer, carbomer, xanthan gum, hydroxypropyl guar, ceratonia siliqua (carob) gum, ammonium polyacryloyldimethyl taurate, ammonium acryloyldimethyltaurate/steareth-25 methacrylate crosspolymer, and polyacrylate crosspolymer-6.
  • the polymeric thickener may be one of carbomer, acrylates/C 10-30 alkyl acrylate crosspolymer, polyacrylate crosspolymer-6, microcrystalline cellulose (and) cellulose gum, xanthan gum, sodium carboxymethyl starch, sclerotium gum (and) xanthan gum, xanthan gum (and) ceratonia siliqua (carob) gum (50/50), dehydroxanthan gum, hydroxypropyl starch phosphate, sclerotium gum (and) xanthan gum (75/25), sclerotium gum, xanthan gum (and) sclerotium gum (and) Lecithin (and) pullulan, or combinations thereof.
  • the composition may comprise two or more polymeric thickeners.
  • the amount of each of the at least one polymeric thickener, when present, may be present in the composition in a range of from about 0.01 % to about 2%, or from about 0.01 % to about 1.5%, or from about 0.3% to about 1.2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • the total amount of polymeric thickener in the composition when present, is present from about 0.01 % to about 5%, or from about 0.02% to about 2%, or from about 0.03% to about 1.5%, or from about 0.1 % to about 0.2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • any suitable combination, sub-combination, range, or sub-range thereof by weight is present from about 0.01 % to about 5%, or from about 0.02% to about 2%, or from about 0.03% to about 1.5%, or from about 0.1 % to about 0.2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the composition.
  • one or more polymeric thickener when present, is present by weight, based on the total weight of the composition, from about 0.01 , 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 1.0, 1.1 , 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1 , 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.5, 4.0, 4.5 to about 5.0 percent, including increments and ranges therein and there between.
  • embodiments of the cosmetic composition may include one or more additional compounds selected from active compounds, in particular keratinous tissue actives, such as, but not limited to, skin actives.
  • active compounds may be selected from the group consisting of: vitamins, for example, Vitamin E, carnosine, hyaluronic acid, panthenol, at least one sun filter, at least one hydroxy acid, and combinations thereof.
  • an active compound is selected from the group consisting of alpha, beta or polyhydroxy acids selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose, and combinations thereof.
  • the cosmetic composition may include one or more of any one of the optional active compounds.
  • the cosmetic composition may include one, or more than one hydroxy acid, one, or more than one vitamin, and the like.
  • Vitamin E may be selected from the group consisting of alpha-tocopherol, beta-tocopherol, delta-tocopherol, gamma-tocopherol, and alpha-tocotrienol, beta- tocotrienol, delta-tocotrienol, gamma-tocotrienol, and derivatives thereof.
  • Salts or derivatives of tocopherols include pharmaceutically acceptable compounds such as acetate, sulfate, succinate, nicotinate, palmitate, allophanate, phosphate, quinone, or halogenated derivatives, esters, or stereoisomers, for example.
  • the invention encompasses the use of Vitamin E derivatives in which substitutions, additions, and other alterations have been made in the 6-chromanol ring and/or side chain, with the proviso that the derivatives maintain the antioxidant activity of Vitamin E.
  • Additional tocopherols can be constructed by conjugation to the ring structure or side chain of various other moieties, such as those containing oxygen, nitrogen, sulfur and/or phosphorus.
  • Tocopherol derivatives can also be made by modifying the length of the side chain from that found in tocopherols such as alpha-, beta-, delta- and gammatocopherol. Tocopherols can also vary in stereochemistry and saturation of bonds in the ring structure and side chain.
  • Additional tocopherol derivatives can be made by conjugation of sugars or other moieties to the side chain or ring structure.
  • Tocopherols include without limitation stereoisomers (e.g., + and - stereoisomers of alpha-tocopherol; (+/-) indicates a racemic mixture) or mixtures of structurally distinct tocopherols (e.g., alpha-plus gamma-tocopherol).
  • Tocopherols may be obtained from Roche, Nutley, N.J., for example.
  • additional actives can also include at least one hydroxy acid selected from alpha, beta or polyhydroxy acids.
  • a hydroxy acid may be selected from the group consisting of lactic acid, glycolic acid, salicylic acid, malic acid, tartaric acid, citric acid, mandelic acid, lactobionic acid, gluconolactone, galactose, and combinations thereof.
  • additional actives can also include one or more of the antioxidants selected from the group consisting of mangiferin, baicalin, resveratrol, tannic acid, polyphenols, amino acids and derivatives thereof, imidazoles, carnosine derivatives, carotenoids, carotenes (such as a-carotene, p-carotene, and lycopene), vitamin A, co-enzyme Q10, bioflavonoids, glutathione, plant extracts (such as rosemary extract, olive leaf extracts), green tea extracts, and combinations thereof.
  • the antioxidants selected from the group consisting of mangiferin, baicalin, resveratrol, tannic acid, polyphenols, amino acids and derivatives thereof, imidazoles, carnosine derivatives, carotenoids, carotenes (such as a-carotene, p-carotene, and lycopene), vitamin A, co-enzyme Q10, bioflavonoids, glutathione
  • the cosmetic composition includes a combination of active compounds present in the cosmetic composition comprising tocopherol, panthenol, hyaluronic acid, hydroxy acid, carnosine, or a combination thereof.
  • each of the optional active compounds is present in the cosmetic composition in an amount from about 0.1 % to about 30%, and in some embodiments, from about 0.5% to about 30%, and in some embodiments, from about 0.5% to about 15%, and in some embodiments, from about 0.1 % to about 1 %, and in some embodiments, from about 1 % to about 2%, or any suitable combination, subcombination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • Vitamin E and its derivatives including, but not limited to tocopherol, may be present in the cosmetic compositions in an amount from about 0.5% to about 2%, and in some embodiments, from about 0.5% to about 1 %, and in some embodiments, from about 1 % to about 2.0%, or any suitable combination, sub-combination, range, or subrange thereof by weight, based on the weight of the cosmetic composition.
  • Carnosine, hyaluronic acid, panthenol may be present in the cosmetic compositions in an amount from about 0.1 % to about 5%, and in some embodiments, from about 0.1 % to about 3%, and in some embodiments, from about 0.5% to about 1.0%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • Carnosine may be present in the cosmetic compositions in an amount from about 0.10% to about 1 %, and in some embodiments, from about 0.20% to about 0.5%, and in some embodiments, from about 0.20% to about 0.25%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • Hyaluronic acid may be present in the cosmetic compositions in an amount from about 0.01 % to about 1 %, and in some embodiments, from about 0.01 % to about 0.1 %, and in some embodiments, from about 0.05% to about 0.07%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • Panthenol may be present in the cosmetic compositions in an amount from about 0.1 % to about 1 %, and in some embodiments, from about 0.1 % to about 0.5%, and in some embodiments, from about 0.2% to about 0.4%, and in some embodiments, from about 0.2% to about 0.25%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • a hydroxy acid may be present in the cosmetic compositions in an amount from about 0.25% to about 10%, and in some embodiments, from about 0.5% to about 8%, and in some embodiments, from about 1 % to about 5%, and in some embodiments, from about 0.25% to about 0.5%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the weight of the cosmetic composition.
  • optional active compounds are present in a composition according to the disclosure, and each of the individual components in the ranges as described herein above, from about 0.01 , 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 , 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 , 22, 23, 24, 25, 26, 27, 28 to about 30 percent by weight, including increments and ranges there between.
  • compositions can also comprise at least one additive used in the cosmetics field which does not affect the properties of the compositions according to the invention, such as, emulsifiers, emollients, fragrances, pH adjusters (citric acid, sodium chloride; neutralizing or pH-adjusting agents (e.g., triethanolamine (TEA) and sodium hydroxide), and combinations thereof), other cosmetically acceptable additives, such as but not limited to, pearlescent agents, silica, and coloring materials; essential oils; fruit extracts, for example, Pyrus Malus (Apple) Fruit Extract, and Aloe Barbadensis Leaf Juice Powder;.
  • emulsifiers emulsifiers, emollients, fragrances
  • pH adjusters citric acid, sodium chloride; neutralizing or pH-adjusting agents (e.g., triethanolamine (TEA) and sodium hydroxide), and combinations thereof
  • other cosmetically acceptable additives such as but not limited to, pearlescent agents, silica, and coloring materials; essential oils; fruit
  • the amount of one or more additives, alone or in combination, present in the composition can be present in the composition according to the disclosure in a range from about 0.001 % to about 20%, by weight, or from about 0.005% to about 0.01 %, or from about 0.01 % to about 0.1 %, or from about 0.15% to about 5%, or from about 0.40% to about 4%, or from about 0.5% to about 2.5% by weight, or from about 1 % to about 2%, or any suitable combination, subcombination, range, or sub-range thereof by weight, based on the total weight of the composition.
  • any one or a combination of additives may be present, by weight, based on the total weight of the composition, each one or the combination present from about 0.001 , 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01 , 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 , 12, 13, 14, 15, 16, 17, 18, 19 to about 20 weight percent, including increments and ranges therein and there between.
  • optional additives are given as examples, it will be appreciated that other optional components compatible with cosmetic applications known in the art may be used that are suitable. It will be appreciated by a skilled artisan that any optional additives are present only to the extent and in amounts that do not materially adversely affect the basic and novel characteristic(s) of the claimed disclosure. Thus, in some embodiments that include optional additives, such optional additives will not materially adversely affect the solubility of the skin actives of the cosmetic composition. And in some embodiments that include optional additives, such optional additives will not materially adversely affect the cosmetic composition forming a single phase solution.
  • the cosmetic composition may include optional additives, for example one or more of phenoxyethanol, terephthalylidene dicamphor sulfonic acid, trisodium ethylenediamine disuccinate, sodium citrate, sodium chloride, hydroxyacetophenone sodium benzoate, potassium sorbate, citric acid, caprylyl glycol, trisodium ethylenediamine disuccinate, or combinations thereof.
  • phenoxyethanol is present as a preservative in the cosmetic composition in a range from about 0.5% to about 2%, and in some embodiments in a range from about 1 % to about 2%.
  • the amount of one or more actives and additives, alone or in combination, when present in the cosmetic composition according to the disclosure can be present in a range from about 0.001 % to about 20%, and in some embodiments, from about 0.05% to about 0.01 %, and in some embodiments, from about 0.01 % to about 0.1 %, and in some embodiments, from about 0.15% to about 5%, and in some embodiments, from about 0.40% to about 4%, and in some embodiments, from about 0.5% to about 2.5%, and in some embodiments, from about 0.1 % to about 0.5%, and in some embodiments, from about 1 % to about 2%, or any suitable combination, sub-combination, range, or sub-range thereof by weight, based on the total weight of the cosmetic composition.
  • One of ordinary skill in the art will appreciate that other ranges are within the scope of the invention.
  • any one or a combination of actives and additives may be present, each one or the combination present from about 0.001 , 0.005, 0.01 , 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.01 , 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80, 0.90, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 , 12, 13, 14, 15, 16, 17, 18, 19 to about 20 percent, by weight, including increments and ranges therein and there between.
  • the cosmetic composition of the present invention may be used for the production of cosmetic preparations, or dermatological preparations, more particularly topical treatment preparations, that may be formulated as single-phase solution compositions, cosmetic serums, or aerosols, for example.
  • Topical application to a surface may be a surface such as the mucus membrane or the skin, for example.
  • the examples below according to the invention are given by way of illustration and without a limiting nature.
  • the names are the chemical name or the INCI name.
  • the amounts of active ingredients are given therein as % by weight based on raw material compositions comprising 100% of the listed ingredient, unless otherwise mentioned.
  • EXAMPLE 1 Inventive Compositions:
  • compositions include other actives that include HA, VIT E + SURFACTANT, PANTHENOL, PRESERVATIVE, and other ingredients including GLYCERIN
  • EXAMPLE 2 Demonstrating Metal Chelation/Sequesterinq
  • EPR Electron paramagnetic resonance
  • an antioxidant solution of either ferulic acid or phytic acid, to which metal is added in a ratio of 1 : 1 and 1 :10, metal to antioxidant provides a removal of metal ions characterized by clustering/removal of free metal ions.
  • Table 4 the results show reduction of metal ions by ferulic and phytic acids.
  • ferulic acid chelates copper to thereby diminish the amount of copper ions by about 60% at a ratio of 1 :1 with the metal, and by about the same (60%) at a ratio of 10:1 (ferulic acid to metal).
  • phytic acid chelates to form aggregates with iron to thereby diminish the amount of iron ions by about 90% at a ratio of 1 : 1 with the metal, and by about 65% at a ratio of 10: 1 (phytic acid to metal).
  • the data further show that ferulic acid has no discernible effect on iron ions and phytic acid effectively reduced copper (II), but does not chelate it.
  • a cosmetic composition according to the disclosure and comprising both ferulic acid and phytic acid provides a removal of metal ions added to the composition.
  • Table 5 the results show reduction of metal ions by ferulic and phytic acids as evidenced by measured residual metal ions.
  • composition according to the disclosure demonstrates removal of free metal ions of about 60% with respect to copper and about 80% of iron.
  • At least one means one or more and thus includes individual components as well as mixtures/combinations.
  • the terms “free” and “devoid” indicates that no reliably measurable excluded material is present in the cosmetic composition, typically 0% by weight, based on the total weight of the cosmetic composition.
  • the term “essentially free” means that, while it prefers that no excluded material is present in the cosmetic composition, it is possible to have very small amounts of the excluded material in the cosmetic composition of the invention, provided that these amounts do not materially affect the advantageous properties of the cosmetic composition.
  • “essentially free” means that excluded material can be present in the cosmetic composition at an amount of less than about 0.1 % by weight, based on the total weight of the cosmetic composition.
  • weight or amount as used herein with respect to the percent amount of an ingredient refers to the amount of the raw material comprising the ingredient, wherein the raw material may be described herein to comprise less than and up to 100% activity of the ingredient. Therefore, weight percent of an active in a composition is represented as the amount of raw material containing the active that is used, and may or may not reflect the final percentage of the active, wherein the final percentage of the active is dependent on the weight percent of active in the raw material.
  • weight percent and “wt%” may be used interchangeably and mean percent by weight, based on the total weight of a composition, article or material, except as may be specified with respect to, for example, a phase, or a system that is a component of a composition, article or material. All ranges and amounts given herein are intended to include subranges and amounts using any disclosed point as an end point. Thus, a range of “1 % to 10%, such as 2% to 8%, such as 3% to 5%,” is intended to encompass ranges of “1 % to 8%,” “1 % to 5%,” “2% to 10%,” and so on.

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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

Selon l'invention, une composition cosmétique comprenant un système de chélation métallique comprend une combinaison d'acide ascorbique, d'acide férulique et d'acide phytique dans un système de vecteur qui comprend de l'eau, et comprend en outre un ou plusieurs autres ingrédients pour fournir l'une d'une variété de formes de produits cosmétiques. La composition cosmétique permet d'éliminer des ions métalliques libres dans un matériau mis en contact avec la composition cosmétique, l'élimination d'ions métalliques libres étant réalisée dans une plage d'au moins environ 40 % jusqu'à environ 99 %.
PCT/IB2021/061877 2020-12-17 2021-12-16 Composition cosmétique capturant des métaux WO2022130292A1 (fr)

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CN202180083873.1A CN116634991A (zh) 2020-12-17 2021-12-16 金属螯隔化妆品组合物
EP21830790.8A EP4262707A1 (fr) 2020-12-17 2021-12-16 Composition cosmétique capturant des métaux
KR1020237023606A KR20230114314A (ko) 2020-12-17 2021-12-16 금속 봉쇄 화장료 조성물

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17/125,945 US20220202671A1 (en) 2020-12-17 2020-12-17 Metal sequestering cosmetic composition
US17/125,945 2020-12-17
FRFR2100579 2021-01-21
FR2100579A FR3118874B1 (fr) 2021-01-21 2021-01-21 Composition cosmétique de séquestration des métaux

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Citations (3)

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US20130123207A1 (en) * 2011-11-16 2013-05-16 Resveratrol Partners, Llc Compositions Containing Resveratrol and Nucleotides
US20200306165A1 (en) * 2019-03-29 2020-10-01 L'oreal Cosmetic composition comprising vitamin c and ceramides

Patent Citations (3)

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US5140043A (en) 1989-04-17 1992-08-18 Duke University Stable ascorbic acid compositions
US20130123207A1 (en) * 2011-11-16 2013-05-16 Resveratrol Partners, Llc Compositions Containing Resveratrol and Nucleotides
US20200306165A1 (en) * 2019-03-29 2020-10-01 L'oreal Cosmetic composition comprising vitamin c and ceramides

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DATABASE GNPD [online] MINTEL; 12 May 2020 (2020-05-12), ANONYMOUS: "Sun Perfector SPF 50+ PA++++", XP055856105, retrieved from https://www.gnpd.com/sinatra/recordpage/7615847/ Database accession no. 7615847 *
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MICHELLE A. OUIMET ET AL: "Biodegradable Ferulic Acid-Containing Poly(anhydride-ester): Degradation Products with Controlled Release and Sustained Antioxidant Activity", BIOMACROMOLECULES, vol. 14, no. 3, 11 March 2013 (2013-03-11), US, pages 854 - 861, XP055376160, ISSN: 1525-7797, DOI: 10.1021/bm3018998 *

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