WO2022190726A1 - 検体採取用スワブ - Google Patents

検体採取用スワブ Download PDF

Info

Publication number
WO2022190726A1
WO2022190726A1 PCT/JP2022/004209 JP2022004209W WO2022190726A1 WO 2022190726 A1 WO2022190726 A1 WO 2022190726A1 JP 2022004209 W JP2022004209 W JP 2022004209W WO 2022190726 A1 WO2022190726 A1 WO 2022190726A1
Authority
WO
WIPO (PCT)
Prior art keywords
specimen
rod
collecting
swab
hair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2022/004209
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
智 池上
浩一 稲野
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denka Co Ltd
Original Assignee
Denka Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denka Co Ltd filed Critical Denka Co Ltd
Priority to JP2023505216A priority Critical patent/JP7466757B2/ja
Publication of WO2022190726A1 publication Critical patent/WO2022190726A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state

Definitions

  • the present disclosure relates to specimen collection swabs.
  • Patent Document 1 describes a swab for collecting biological specimens of the type consisting of a rod having a tip at its end covered with a hydrophilic fiber that absorbs the biological specimen. This sampling swab is characterized in that the fibers cover the chip in the form of a layer applied by flocking.
  • Specimen collection using the collection swab shown in Patent Document 1 and the like is performed, for example, by bringing the swab into contact with the mucous membrane of the mouth, nose, etc. of the patient from whom the specimen is to be collected. At this time, the swab is pressed against the patient's mucous membrane in order to collect more than the minimum required amount of specimen. In this case, there is a problem that the patient feels discomfort, pain, etc. due to being pressed against the swab. Accordingly, an object of one aspect of the present disclosure is to provide a specimen collection swab that allows sufficient specimen collection while reducing patient discomfort, pain, and the like.
  • a specimen collection swab is as follows. [1] A rod and a sample-collecting portion provided at the end of the rod, wherein the sample-collecting portion is a buffer portion that is deformable by external pressure and includes at least a napped body that constitutes the surface thereof; and the napped body has a substrate portion and a bristle-like body provided on the surface of the substrate portion in the form of a brush. [2] The specimen-collecting swab according to [1], wherein the cushioning section is fixed to the end of the rod or has a hollow molded portion integrally molded with the rod.
  • the hair-like body has a proximal portion protruding from the base portion, and an expanded portion provided at the tip of the proximal portion and having a maximum outer diameter larger than the outer diameter of the proximal portion, The specimen-collecting swab according to any one of [1] to [4], wherein the expanded portion has a hollow shape.
  • the hair-like body has a base portion projecting from the base portion, a tip portion extending toward the buffer portion, and a curved portion connecting the base portion and the tip portion, [1] to [5 ]
  • a specimen collection swab that can sufficiently collect a specimen while reducing patient discomfort and pain.
  • FIG. 1(a) is a schematic diagram showing the swab according to the first embodiment
  • FIG. 1(b) is a schematic cross-sectional view of FIG. 1(a).
  • FIG. 2(a) is a schematic diagram showing an example of a napped body before being provided on a swab
  • FIG. 2(b) is a schematic cross-sectional view of the main part of the napped body.
  • FIG. 3(a) is a schematic cross-sectional view showing a swab according to a first modified example of the first embodiment
  • FIG. 3(b) shows a swab according to a second modified example of the first embodiment. It is a schematic sectional view.
  • FIG. 1(a) is a schematic diagram showing the swab according to the first embodiment
  • FIG. 1(b) is a schematic cross-sectional view of FIG. 1(a).
  • FIG. 2(a) is a schematic diagram showing an example of a napped body before being provided
  • FIG. 4(a) is a schematic diagram showing a swab according to the second embodiment
  • FIG. 4(b) is a schematic cross-sectional view of FIG. 4(a).
  • FIG. 5 is a schematic diagram showing a swab according to the third embodiment.
  • FIG. 6 is a schematic cross-sectional view showing another example of the napped body.
  • a swab according to each embodiment described below is, for example, a member (specimen-collecting swab) used for specimen collection.
  • a sample is a liquid biological sample obtained from a living organism such as a human body or an animal.
  • Biological specimens are, for example, pharyngeal swabs, nasal swabs, pharyngeal lavages, nasal lavages, nasal aspirates, saliva, serum, stool, stool suspensions, urine, culture fluids, and the like.
  • Biological specimens may include solids.
  • FIG. 1(a) is a schematic diagram showing a swab according to the first embodiment.
  • FIG. 1(b) is a schematic cross-sectional view of FIG. 1(a).
  • the swab 1 has a rod 2 and a specimen collecting portion 3.
  • the direction in which the rod 2 extends is defined as the axial direction X for description.
  • the rod 2 is a rod-shaped member that serves as a grip for the person who collects the sample, and has a pair of ends 2a and 2b in the axial direction X.
  • the end portion 2a is a portion used as a grip portion.
  • the surface of the end portion 2a may be provided with anti-slip processing, for example.
  • Anti-slip processing includes, for example, embossing and coating with an anti-slip member.
  • the end portion 2b is a portion where the specimen collecting portion 3 is provided. In the first embodiment, part of the end portion 2b is located inside the specimen collecting portion 3. As shown in FIG. At least the end 2b of the rod 2 may be flexible.
  • the rod 2 when a force is applied to the sample-collecting portion 3 during sample collection, the force concentrated on the boundary between the rod 2 and the sample-collecting portion 3 can be alleviated. Therefore, it is possible to prevent the swab 1 from being damaged at the boundary or the like, and the rod 2 from being broken.
  • the rod 2 is broken corresponds to a state in which the rod 2 is irreversibly deformed. When the rod 2 is broken, the broken part of the rod 2 may come into contact with or damage the sample collection site or its vicinity. In addition, when the sample collection site is a part of a living organism, the living organism may feel pain or the like. Furthermore, there is also a possibility that the sample collecting section 3 cannot reach the sample collecting site.
  • the rod 2 has, for example, a columnar shape or a polygonal columnar shape, but is not limited to this.
  • the thickness (diameter or outer diameter) of the end portion 2a may be larger than the thickness of the end portion 2b. In this case, the rod 2 may become thinner as it approaches the end 2b along the axial direction of the rod 2 .
  • the diameter of the rod 2 is, for example, 0.5 mm or more and 3 mm or less.
  • the length of the rod 2 along the axial direction X is, for example, 30 mm or more and 200 mm or less.
  • the rod 2 is made of materials such as bamboo, wood, hard paper, metal, and resin, for example.
  • the rod 2 may be made of multiple materials.
  • a portion of the rod 2 including the end portion 2a may be made of hard paper or the like, and another portion of the rod 2 including the end portion 2b may be made of resin or the like.
  • part of the rod 2 can be made rigid and the other part of the rod 2 can be made flexible.
  • Resins include, for example, polyethylene, polycarbonate, polyamide, polyacetal, polybutylene terephthalate, PET (polyethylene terephthalate), polyphenylene sulfide, PEEK (polyetheretherketone), polytetrafluoroethylene, polyvinylidene fluoride, vinyl chloride, nylon, polypropylene, Examples include ABS (acrylonitrile-butadiene-styrene copolymer).
  • the resin may be heat-resistant polycarbonate, PET, ABS, or the like.
  • the resin may contain additives such as glass fibers.
  • the sample collecting part 3 is a part that collects a sample by contacting the mucous membrane of a living organism, and is fixed to the end 2b of the rod 2.
  • the sample collecting part 3 has, for example, a spherical shape, an oval shape, an egg shape, or the like.
  • the specimen collecting portion 3 has a substantially elliptical shape. Therefore, at least a part of the surface of the specimen collecting portion 3 has a smooth curved surface.
  • the specimen collecting part 3 has a buffer part 11 and a nap body 12 .
  • the buffer portion 11 is a molded member fixed to the end portion 2b of the rod 2 and deformable by external pressure.
  • the external pressure is, for example, the force applied when the specimen collecting section 3 is pressed against the specimen collecting site.
  • the force applied to the specimen collection site can be relieved by deforming the buffer part 11 along the shape of the specimen collection site due to external pressure.
  • the cushioning portion 11 can be deformed by applying a force of 0.01 N/mm 2 or more, for example.
  • the deformation of the buffer portion 11 may be elastic deformation or plastic deformation. In the former case, the buffer portion 11 has elasticity.
  • the hardness of buffer portion 11 may be lower than that of rod 2 or higher than that of rod 2 . At least part of the buffer portion 11 may be damaged by deformation.
  • the buffer portion 11 has a body portion 11a and an opening portion 11b.
  • the main body part 11a is a hollow molded part having, for example, a spherical shape, an oval shape, an egg shape, etc., and is fixed to the end portion 2b of the rod 2.
  • the maximum diameter of the body portion 11a along the direction orthogonal to the axial direction X is larger than the thickness of the rod 2, and is, for example, 3.5 mm or more and 10 mm or less.
  • the length of the main body portion 11a along the axial direction X is, for example, 3.5 mm or more and 10 mm or less.
  • the thickness of the body portion 11a is, for example, 0.05 mm or more and 1.5 mm or less.
  • the thickness of the main body portion 11a may be smaller than the thickness of the rod 2, and may be 0.1 mm or more and 0.5 mm or less.
  • the surface of the main body portion 11a may be provided with irregularities, or may be provided with openings.
  • the main body portion 11a may be a mesh basket-like hollow lattice formed of metal wires or the like.
  • the body portion 11a is a resin molding formed by injection molding, balloon molding, or the like.
  • the resin contained in the main body portion 11a is, for example, a thermoplastic resin or the like. From the viewpoint of suppressing the influence of specimen collection, the main body 11a may have water repellency or waterproofness.
  • the opening 11b is a portion into which the end 2b of the rod 2 is inserted, and is provided at a position (base end) closest to the end 2a in the axial direction X of the main body 11a.
  • the end portion 2b is positioned inside the buffer portion 11 through the opening 11b, the end portion 2b is positioned closer to the end portion 2a than the center C of the buffer portion 11 in the axial direction X.
  • cushioning portion 11 is less likely to come into contact with end portion 2b.
  • the end portion 2b and the specimen collecting portion 3 are adhered to each other via an adhesive AD, for example.
  • the adhesive AD also functions as a filler that fills the gap between the end portion 2b and the opening portion 11b. As a result, the specimen can be prevented from entering the interior of the buffer section 11 .
  • the adhesive AD contains, for example, at least one of thermoplastic resin, thermosetting resin, and elastomer resin. From the viewpoint of hygiene and the like, the adhesive AD may contain a silicone resin, an acrylic resin, or the like. From the viewpoint of resistance to polar organic compounds such as alcohol, the main component of the adhesive AD may be a silicone resin.
  • the adhesive AD may contain additives as appropriate.
  • FIG. 2(a) is a schematic diagram showing an example of a napped body before being provided on a swab
  • FIG. 2(b) is a schematic cross-sectional view of the main part of the napped body.
  • the napped body 12 is a portion of the sample-collecting portion 3 that abuts on the sample-collecting site, and collects and temporarily holds the sample.
  • the napped body 12 before being attached to the swab 1 has a sheet shape.
  • the napped body 12 constitutes the surface of the cushioning portion 11 by covering the body portion 11 a of the cushioning portion 11 .
  • the napped body 12 may cover the entire surface of the buffer portion 11 . Moreover, the napped body 12 may cover a part of the rod 2 .
  • the napped body 12 is fixed to the buffer portion 11 via, for example, an adhesive (not shown).
  • the feeling of coolness to the touch of the napped body 12 can be indicated by the heat transfer rate q-max at the time of contact.
  • a larger q-max value indicates a colder temperature, and a smaller q-max value indicates a warmer temperature.
  • q-max may be 0.005 W/cm 2 or more and 0.500 W/cm 2 or less, or 0.200 W/cm 2 or more and 0.450 W/cm 2 or less .
  • the napped body 12 has a substrate portion 21 and hairy bodies 22 .
  • the base material portion 21 is a portion that is fixed to the buffer portion 11 and supports the hair-like body 22, and has a first surface 21a and a second surface 21b.
  • the first surface 21a is a surface facing the buffer portion 11 (see (b) of FIG. 1), and the second surface 21b is an exposed surface.
  • the base material portion 21 has a sheet shape, band shape, string shape, or thread shape. From the viewpoint of breakage prevention, ease of manufacture of the hairy bodies 22, manufacturing cost, etc., the thickness of the base material portion 21 may be 50 ⁇ m or more and 1000 ⁇ m or less, 100 ⁇ m or more and 900 ⁇ m or less, or 150 ⁇ m or more and 800 ⁇ m or less. .
  • the material of the base material portion 21 is not particularly limited as long as the hair-like body 22 is provided and can be fixed to the buffer portion 11 by winding or the like.
  • Examples of the material of the base material portion 21 include cloth, fiber, thread, non-woven fabric, natural resin, synthetic resin, paper, animal skin, and fur. From a sanitary point of view, the material of the base material portion 21 may be cloth, fiber, or synthetic resin, for example.
  • Examples of synthetic resins include thermoplastic resins. At least one of styrene-based resin, olefin-based resin, polyvinyl chloride resin, thermoplastic elastomer, fluorine-based resin, polyester-based resin, and nylon-based resin is used as the thermoplastic resin.
  • the base material portion 21 may have waterproof properties, antibacterial properties, chemical resistance, antistatic properties, and the like.
  • the surface of the base material portion 21 may be subjected to waterproof processing, antibacterial processing, antistatic processing, or the like.
  • the hair-like body 22 is a portion that holds the specimen, and is provided in the shape of a brush on the second surface 21b of the base material portion 21 .
  • the plurality of hair-like bodies 22 are arranged regularly or irregularly on the second surface 21b.
  • the sample-collecting part 3 is pressed against the sample-collecting site, the sample adheres between the hair-like bodies 22 .
  • sample collection with the swab 1 is performed.
  • the plurality of hair-like bodies 22 are regularly arranged, the plurality of hair-like bodies 22 are arranged orderly along one or more directions when viewed from the thickness direction of the base material portion 21 . This can improve the tactile sensation of the hair-like bodies 22 .
  • the tactile sensation of the hair-like body 22 is the feel given to a patient or the like who has the sample collection site.
  • the tactile properties of the hair-like bodies 22 are improved, the patient or the like to whom the swab 1 is pressed tends to obtain favorable tactile sensations such as moistness, softness, and airiness. Therefore, the more the tactile properties of the hair-like bodies 22 are improved, the less discomfort and pain the patient or the like against which the swab 1 is pressed.
  • the hair-like bodies 22 have a tapered shape that stands substantially upright along the thickness direction of the base material portion 21 .
  • the length of hairs 22 may correspond to the height of hairs 22 .
  • substantially upright means that the short fibers exist in a substantially upright state, although it is not required that the short fibers exist in a state perpendicular to the second surface 21b of the base material portion 21 . From the viewpoint of exhibiting the sample holding function of the napped body 12 well, even when the napped body 12 is fixed to the buffer part 11, the hairy body 22 stands upright with respect to the second surface 21b of the base material portion 21. .
  • the average height H1 of the hairy bodies 22 is, for example, 200 ⁇ m or more and 700 ⁇ m or less.
  • the average height H1 may be 300 ⁇ m or more from the viewpoint of the amount of sample to be collected, the improvement of the tactile sensation of the hair-like body 22, and the like.
  • the average height H1 may be 600 ⁇ m or less from the viewpoint of reducing the discomfort of the patient pressed against the swab 1 .
  • the average height H1 is obtained, for example, by cutting out cross-sections (samples) from arbitrary three locations of the napped body 12 and measuring the height of ten hairy bodies for each sample, a total of 30 measurement results.
  • the average diameter (average outer diameter) of the hairy bodies 22 is, for example, 10 ⁇ m or more and 200 ⁇ m or less. From the viewpoint of improving the tactile sensation of the hair-like bodies 22, the average diameter may be 20 ⁇ m or more. The average diameter may be 150 ⁇ m or less from the viewpoint of reducing the discomfort of the patient pressed against the swab 1 .
  • the average diameter is, for example, a value obtained by using the arithmetic mean value of the results of measuring the diameter of the intermediate height of the hair-like body 22 from several points on the napped body 12 .
  • the outer diameter of the hair-like body 22 is, for example, 1 ⁇ m or more and 250 ⁇ m or less.
  • An average interval P of the hair-like bodies 22 is, for example, 20 ⁇ m or more and 200 ⁇ m or less.
  • the interval between the hair-like bodies 22 corresponds to the distance between the center of one root and the center of the other of the two adjacent hair-like bodies 22 . From the viewpoint of sampling, etc., the average interval P may be 150 ⁇ m or less.
  • the number of hair-like bodies 22 per unit area of the base material portion 21 (that is, the density of the hair-like bodies 22) is not particularly limited, but is, for example, 1000/cm 2 or more and 100000/cm 2 or less. There is a tendency that the higher the density of the hair-like bodies 22 is, the higher the specimen retention efficiency is. Therefore, the density of the hair-like bodies 22 per unit area may be 10000/cm 2 or more. For example, even if the sample is nasal mucus or the like, in order for the hair-like bodies 22 to exhibit the sample-holding function satisfactorily, it is necessary to maintain the raised state of the hair-like bodies 22 even in a viscous liquid.
  • the fibrous bodies 22 need to have fineness and surface area that can provide a certain level of strength.
  • the fineness of the hairs 22 is the weight in grams per unit length of a single fiber, line.
  • the fineness of the hair-like bodies 22 may be 1.0 dtex or more and 4.0 dtex, or 1.5 dtex or more and 3.0 dtex, depending on the strength, workability, bendability, etc. of the hair-like bodies 22 .
  • the base material portion 21 and the hair-like bodies 22 are integrally formed using a thermoplastic resin.
  • a thermoplastic resin there is no structural boundary between the substrate portion 21 and the hair-like bodies 22, forming a continuous phase.
  • No structural boundary means that there is no structurally distinct boundary between the substrate portion 21 and the hairs 22 .
  • forming a continuous phase means that there is no seam between the substrate portion 21 and the hair-like bodies 22, and there is no discontinuity.
  • the base material portion 21 and the hair-like members 22 are formed, for example, by melt extruding a thermoplastic resin from a die by extrusion molding, and then casting using a transfer roll and a touch roll having unevenness processing.
  • the thermoplastic resin has an elongation viscosity ⁇ (t) (unit: Pa S) measured at an elongation temperature at a strain rate of 0.5 (unit: S ⁇ 1 ) on the vertical axis, and an elongation time t (unit: S ) on the horizontal axis, there is a region where the slope (log ⁇ /logt) is 0.5 or less in the interval 0.1 ⁇ t ⁇ 1.0.
  • the temperature range in which the adhesive force of the thermoplastic resin is 0.05 N/mm 2 or more and 0.25 N/mm 2 or less overlaps at least partly with the elongation temperature.
  • the stretchable temperature refers to a temperature at which a thermoplastic resin exhibits plasticity and can be stretched (for example, stretchable).
  • the elongation temperature can be determined from the state of the strand (thermoplastic resin molding) set in a uniaxial elongation viscometer and elongated at various temperatures. When the temperature is low, the resin does not exhibit plasticity (in a rigid state), and the rolls fixing the strands will idle. In addition, when the temperature is high, the resin becomes a molten state and cannot be fixed to the roll, or the elongation viscosity when fixed and elongated is less than 1.0 ⁇ 10 4 (unit: Pa S). Strand breaks.
  • the elongational viscosity is measured using a commercially available elongational viscometer at a temperature at which the thermoplastic resin can be elongated (eg, 100°C, 110°C, 120°C, 130°C, 140°C, 150°C or 160°C). It can be measured at strain rates of 17S ⁇ 1 , 0.5S ⁇ 1 or 0.83S ⁇ 1 .
  • Probe tack measurements include, for example, Wetzel's method, Kobe-Kamagata method, Hammond's method, and Lesca method.
  • the probe tack measurement other than the Lesca method first, the probe is approached from below to the sample placed with the adhesive surface of the sample facing downward. Subsequently, after contact between the sample and the probe, the probe is moved downward at a constant speed, and the force required to peel the probe off the adhesive surface is detected.
  • the Lesca method the sticky side of the sample faces up, the probe is pressed against the sticky side from above, and then the force to remove the probe from the sticky side is detected.
  • the Lesca method is preferably used.
  • the thermoplastic resin adheres appropriately to the transfer roll surface and forms the hair-like members 22.
  • the range of the adhesive force may be 0.05 N/mm 2 or more and 0.25 N/mm 2 or less.
  • a specimen is collected by bringing the specimen collection portion 3 of the swab 1 into contact with the specimen collection site.
  • the specimen collection section 3 may not only be brought into contact with the specimen collection site, but may also be rubbed against the specimen collection site.
  • the specimen is suspended or suspended in the specimen-treated liquid by immersing the specimen-collecting part 3 in the specimen-treated liquid.
  • the sample treatment liquid is appropriately prepared depending on the type of sample.
  • the sample treatment liquid contains, for example, a pH buffer, a surfactant, and the like.
  • the sample is filtered using a filtration filter to obtain a filtrate.
  • the filtrate is supplied to a substrate (for example, a membrane or the like) of an inspection device, and the substrate is immersed in the filtrate.
  • a capture reagent that captures the target substance by specifically binding to the target substance is bound to the surface of the base material. Therefore, the substance to be detected in the filtrate is trapped on the substrate.
  • a labeling substance which is a detection reagent that specifically binds to the substance to be detected, is added dropwise or the like onto the substrate.
  • the swab 1 can be used to measure the presence or absence of the analyte in the sample collected.
  • the sample-collecting part 3 has a buffer part 11 that can be deformed by external pressure, and a nap body 12 that constitutes the surface of the buffer part 11 .
  • the buffer unit 11 deforms along the shape of the mucous membrane or the like. In this case, it is possible to increase the area of the specimen-collecting part 3 that contacts the mucous membrane or the like without pressing the specimen-collecting part 3 strongly against the mucous membrane or the like for a long time.
  • the sample collecting part 3 when inserting the sample collecting part 3 into a nostril or the like, it becomes less likely to get caught before the target point.
  • the napped body 12 since the napped body 12 has the hair-like bodies 22 provided in a brush shape, the sample is efficiently retained by the hair-like bodies 22 . Therefore, by using the swab 1, it is possible to sufficiently collect a specimen while reducing patient discomfort and pain.
  • the buffer portion 11 has a main body portion 11a which is a hollow molded portion fixed to the end portion 2b of the rod 2. Therefore, the buffer portion 11 can be easily deformed by external pressure. Therefore, the patient's discomfort, pain, etc. can be reduced satisfactorily.
  • At least the end 2b of the rod 2 may have flexibility.
  • the force concentrated on the boundary between the rod 2 and the sample-collecting portion 3 can be alleviated.
  • FIG. 3 is a schematic cross-sectional view showing a swab according to a first modified example of the first embodiment.
  • the entire rod 2A is located outside the specimen collecting portion 3A. That is, in the first modified example, part of the end portion 2b of the rod 2A is not positioned inside the buffer portion 11A. Therefore, the buffer portion 11A does not have an opening.
  • the buffer portion 11A is fixed to the end portion 2b by using an adhesive AD, for example, but the present invention is not limited to this.
  • the buffer portion 11A may be fixed to the end portion 2b by welding at least one of the buffer portion 11A and the end portion 2b to the other.
  • At least the end portion 2b may be flexible from the viewpoint of suppressing the occurrence of breakage at the boundary between the buffer portion 11A and the end portion 2b. Also in the first modified example described above, the same effects as those of the above-described embodiment are exhibited.
  • FIG. 3 is a schematic cross-sectional view showing a swab according to a second modification of the first embodiment.
  • the buffering portion 11B of the specimen collecting portion 3B is formed integrally with the rod 2B.
  • the rod 2B and the buffer portion 11B are integrally molded by balloon molding. Therefore, the rod 2B is formed with a through hole 2c that communicates with the internal space of the buffer portion 11B.
  • the through hole 2c may be sealed at the end 2a of the rod 2B.
  • the same effects as those of the above-described embodiment are exhibited. In addition, breakage at the boundary between the buffer portion 11B and the rod 2B is less likely to occur.
  • FIG. 4 is a schematic diagram showing a swab according to the second embodiment.
  • FIG. 4(b) is a schematic cross-sectional view of FIG. 4(a).
  • the specimen collecting portion 3C of the swab 1C includes a buffer portion 11C different from the buffer portion 11 of the first embodiment, and a nap body 12 covering the buffer portion 11C.
  • the base-material part 21 of the nap body 12 has waterproofness.
  • the buffer section 11C has a porous body 31 that can be deformed by external pressure.
  • the porous body 31 may be a macroporous material or a mesoporous material.
  • the porous body 31 may be formed from a natural porous material (for example, activated carbon, pumice stone, wood, cork, etc.), or may be formed from an artificial porous material (for example, foamed polyurethane, zeolite, etc.). good.
  • the porous body 31 is made of an artificial porous material from the viewpoint of satisfactorily exhibiting the function (deformation function by external pressure) as the buffer portion 11C.
  • the porous body 31 can have a function of retaining liquid.
  • the buffer portion 11 ⁇ /b>C is covered with the base portion 21 .
  • the entire buffer portion 11 ⁇ /b>C may be reliably covered with the base portion 21 .
  • collection and retention of the specimen by the porous body 31 can be inhibited by the napped body 12 .
  • the porous body 31 is provided with a recess 31a into which the end portion 2b of the rod 2 is inserted.
  • the porous body 31 is fixed to the end portion 2b via, for example, an adhesive (not shown).
  • the specimen collecting portion 3C when the specimen collecting portion 3C is pressed against the mucous membrane of the human body, etc., a buffering effect is generated due to the deformation and/or breakage of the buffering portion 11C. For this reason, also in the second embodiment, the same effects as those of the first embodiment can be obtained.
  • the entire buffer section 11C can be flexibly configured. In this case, when the patient's mucous membrane or the like is rubbed with the specimen collecting portion 3C in order to increase the amount of specimen collected, the patient is less likely to feel a foreign body sensation.
  • the buffer portion 11C is covered with the base material portion 21 having waterproofness. Therefore, the function of holding the specimen by the porous body 31 can be inhibited by the napped body 12 . Therefore, it is possible to satisfactorily prevent the collection of excessive specimens. Further, in the second embodiment, the end portion 2b of the rod 2 is embedded in the recess 31a of the porous body 31. As shown in FIG. Therefore, the force concentrated on the boundary between the buffer portion 11C and the rod 2 can be dispersed.
  • FIG. 5 is a schematic diagram showing a swab according to the third embodiment.
  • the buffer portion 11D included in the specimen collecting portion 3D of the swab 1D has a roll of napped body 12.
  • the sample collecting portion 3D is formed only from a roll of the strip-shaped napped body 12, and is formed by winding the napped body 12 around the end portion 2b. Therefore, in the sample collecting portion 3D, part of the napped body 12 forms the inside of the buffer part 11D, and the other part of the napped body 12 forms the surface of the buffer part 11D.
  • One end of the nap body 12 is fixed to the end portion 2b via an adhesive or the like.
  • a method of forming the wound body (that is, a method of winding the napped body 12 around the end portion 2b) is not particularly limited.
  • the wound body may be formed, for example, by winding the napped body 12 circularly like a loop band, or by spirally winding it like a spiral band, or a folded band. , or may be formed by winding in a figure-eight pattern.
  • An irregular-shaped gap (not shown) is provided inside the wound body.
  • the specimen collecting portion 3D when the specimen collecting portion 3D is pressed against the mucous membrane of the human body, a cushioning effect is generated due to the gaps in the wound body. For this reason, also in the third embodiment, the same effects as those of the first embodiment can be obtained. In addition, by changing the number of turns of the napped body 12 with respect to the end portion 2b, the size of the specimen collecting portion 3D can be easily adjusted.
  • the specimen-collecting swab according to one aspect of the present disclosure is not limited to the above-described embodiments and modifications, and various other modifications are possible. Moreover, the above embodiment and the above modifications may be combined as appropriate.
  • the contents of the third embodiment may be combined with the first embodiment.
  • the buffer part of the specimen collecting part has a hollow molded part and a roll of nap.
  • the content of the third embodiment may be combined with the second embodiment.
  • the buffer part of the specimen collecting part has a porous body and a roll of napped body. In these cases, the cushioning action of the cushioning portion can be exhibited more satisfactorily.
  • the hair-like body has a tapered shape, but is not limited to this.
  • the hair-like body may have a columnar shape or the like.
  • the tips of the hairs may be thicker than the roots of the hairs.
  • the outer diameter of the hair-like bodies may gradually decrease as the distance from the substrate portion increases, and then the outer diameter may increase once.
  • the hair-like body has a proximal portion protruding from the base portion, and an expanded portion provided at the tip of the proximal portion and having a maximum outer diameter larger than the outer diameter of the proximal portion. You may In this case, the function of holding the sample by the hairy body can be improved.
  • the expanding portion may have a hollow shape.
  • FIG. 6 is a schematic cross-sectional view of main parts showing another example of the napped body.
  • the hair-like body 22A of the napped body 12A shown in FIG. It has an extending distal portion 42 and a curved portion 43 connecting proximal portion 41 and distal portion 42 .
  • the base end portion 41 is inclined with respect to the second surface 21b of the base portion 21, but this is not restrictive.
  • the curved portion 43 extends from the distal end of the proximal portion 41 and is curved with a constant curvature or a gradual change in curvature.
  • the tip portion 42 is a portion extending from the tip of the curved portion 43 . At least part of the tip portion 42 may extend toward the buffer (not shown). Therefore, for example, the tips of the hair-like bodies 22A included in the tip portion 42 may face away from the cushioning portion (not shown). In this case, the tip portion 42 and the curved portion 43 of the hair-like body 22A easily hold the specimen, so that the holding function of the napped body 12A can be improved.
  • the base material portion and the hair-like body included in the napped body are integrally formed, but the present invention is not limited to this.
  • the napped body may be provided by fixing short fibers that form the hairy body to the base material portion.
  • one end of the short fiber is fixed to the second main surface of the base material portion.
  • a method for fixing the short fibers to the base material portion is not particularly limited.
  • short fibers are fixed to the substrate portion by electric flocking (flock method) using an electrostatic field.
  • the substrate portion may already cover the buffer prior to the flocking process.
  • the short fibers may be made of materials with high liquid absorption efficiency (eg, nylon, polyester, polyamide, etc.).
  • the material having a high liquid absorption efficiency may be a material having a higher liquid absorption efficiency than the material forming the base portion.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hydrology & Water Resources (AREA)
  • Sampling And Sample Adjustment (AREA)
PCT/JP2022/004209 2021-03-11 2022-02-03 検体採取用スワブ Ceased WO2022190726A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023505216A JP7466757B2 (ja) 2021-03-11 2022-02-03 検体採取用スワブ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021039172 2021-03-11
JP2021-039172 2021-03-11

Publications (1)

Publication Number Publication Date
WO2022190726A1 true WO2022190726A1 (ja) 2022-09-15

Family

ID=83227836

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2022/004209 Ceased WO2022190726A1 (ja) 2021-03-11 2022-02-03 検体採取用スワブ

Country Status (2)

Country Link
JP (1) JP7466757B2 (https=)
WO (1) WO2022190726A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240119532A (ko) * 2023-01-30 2024-08-06 에이치엘비 주식회사 검체 채취용 섬유의 제조방법 및 검체 채취용 섬유

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707450A (en) * 1986-09-25 1987-11-17 Nason Frederic L Specimen collection and test unit
JP2002263108A (ja) * 2001-03-13 2002-09-17 Olympus Optical Co Ltd サンプル採取具
JP2009058260A (ja) * 2007-08-30 2009-03-19 Sato Kasei Kogyosho:Kk 綿棒軸
JP2013224951A (ja) * 2013-06-13 2013-10-31 Denka Seiken Co Ltd 生物学的検体の採取用スワブ、該スワブの製造方法及び該スワブを用いたキット
JP2019076060A (ja) * 2017-10-26 2019-05-23 学校法人 創価大学 光合成微生物用培養容器

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2263548B1 (en) 2010-04-21 2013-06-26 Puritan Medical Products Company, LLC Collection device and material

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707450A (en) * 1986-09-25 1987-11-17 Nason Frederic L Specimen collection and test unit
JP2002263108A (ja) * 2001-03-13 2002-09-17 Olympus Optical Co Ltd サンプル採取具
JP2009058260A (ja) * 2007-08-30 2009-03-19 Sato Kasei Kogyosho:Kk 綿棒軸
JP2013224951A (ja) * 2013-06-13 2013-10-31 Denka Seiken Co Ltd 生物学的検体の採取用スワブ、該スワブの製造方法及び該スワブを用いたキット
JP2019076060A (ja) * 2017-10-26 2019-05-23 学校法人 創価大学 光合成微生物用培養容器

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240119532A (ko) * 2023-01-30 2024-08-06 에이치엘비 주식회사 검체 채취용 섬유의 제조방법 및 검체 채취용 섬유
KR102889039B1 (ko) 2023-01-30 2025-11-21 에이치엘비 주식회사 검체 채취용 섬유의 제조방법 및 검체 채취용 섬유

Also Published As

Publication number Publication date
JPWO2022190726A1 (https=) 2022-09-15
JP7466757B2 (ja) 2024-04-12

Similar Documents

Publication Publication Date Title
JP5453529B2 (ja) 採取デバイスおよび材料
AU2002337786B2 (en) Method and apparatus for collecting and testing biological samples
JP4579902B2 (ja) 生物学的検体の採取用スワブ
Gao et al. Soft pin-shaped dry electrode with bristles for EEG signal measurements
CN103930612B (zh) 导电性高分子纤维、导电性高分子纤维的制造方法以及制造装置、生物体电极、生物体信号测定装置、体内嵌入型电极以及生物体信号测定装置
JP2011234666A (ja) 綿棒
JP6686244B2 (ja) 電極素子及び電極の生産方法、並びに、当該電極を用いる測定システムの作製
KR20110006452U (ko) 검체 채취용 면봉
US11553866B2 (en) Nanofiber mesh bioelectrode, and method for producing the same
CN113243921A (zh) 柔性生物电干电极及制作方法、柔性基底薄膜的制作方法
WO2022190726A1 (ja) 検体採取用スワブ
JP5686853B2 (ja) 生物学的検体の採取用スワブ、該スワブの製造方法及び該スワブを用いたキット
Xiong et al. Advancements in dry and semi-dry EEG electrodes: Design, interface characteristics, and performance evaluation
US20130198987A1 (en) Interdental cleaning member and manufacturing method thereof
EP3745912B1 (en) An improved bristle for brushes
WO2022138449A1 (ja) スキンケア製品用不織布、フェイスマスクおよびクレンジングシート
CN217447856U (zh) 一种宫颈细胞自取样装置
JP4602097B2 (ja) 貼付薬用伸縮性不織布
KR20160102149A (ko) 칫솔
KR102518074B1 (ko) 구강 상피세포 채취 기구
US12097045B2 (en) Slip-resistance patch for oral devices
CN217611158U (zh) 一种一次性医用拭子
CN105250050B (zh) 一种无张力悬吊带系统
KR200427909Y1 (ko) 아이라이너 도포구
Thompson Technical Tips: Cyanoacrylate Better Than Collodion?

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22766691

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2023505216

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 22766691

Country of ref document: EP

Kind code of ref document: A1