WO2022169340A1 - 삼차원 전립선 병리 이미지 생성방법 및 그 시스템 - Google Patents
삼차원 전립선 병리 이미지 생성방법 및 그 시스템 Download PDFInfo
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Definitions
- the present invention relates to a three-dimensional prostate pathology image generating system and system, and more particularly, to a method and system capable of generating a three-dimensional prostate pathology image in which a result of diagnosis through biopsy is mapped to a three-dimensional prostate image. will be.
- Transrectal Ultrasound Guided Prostate Biopsy is the most commonly used biopsy for the diagnosis of prostate cancer.
- Transrectal ultrasound biopsy is a method in which an ultrasound probe is inserted into the rectum to observe the shape of the prostate, and a specimen is collected by inserting a specimen collection needle into the area where the prognosis of cancer is predicted.
- transrectal ultrasound biopsy has the disadvantage of requiring relatively extensive excision of the vicinity of the sample site, since it cannot precisely specify the location of the sample taken in the prostate.
- Transperineal Template Prostate Mapping Biopsies is a test method that uses a tool called a template to specify the location of a needle that collects a sample.
- This transperineal template biopsy method can relatively accurately specify the position where the needle is injected through a device called a template, but only specifies the injection position of the needle.
- Non-Patent Document 2 https://www.researchgate.net/publication/273324840_PROMIS_-_Prostate_MR_imaging_study_A_paired_validating_cohort_study_evaluating_the_role_of_multi-parametric_MRI_in_men_with_clinical_suspicion_of_prostate_cancer)
- the technical problem to be achieved by the present invention is to provide a method and system that can be helpful in treatment by relatively accurately visualizing the location of a sample taken through a biopsy on a three-dimensional image of the prostate and the expression location of prostate cancer as a result of the examination of the sample.
- the three-dimensional prostate pathology image generating method for achieving the above technical problem includes the steps of: a three-dimensional prostate pathology image generating system specifies a three-dimensional prostate image; Obtaining at least one sample-specific digital diagnosis result corresponding to predetermined template coordinates obtained through Transperineal Template Prostate Biopsy (TTPB); and displaying, on the three-dimensional prostate image, an onset site of prostate cancer present in the at least one specimen based on the digital diagnosis result.
- TTPB Transperineal Template Prostate Biopsy
- the three-dimensional prostate pathology image generating method may further include displaying the position of the specimen for each specimen on the three-dimensional prostate image.
- the three-dimensional prostate pathology image generating method includes the steps of specifying an estimated onset site based on a plurality of onset sites included in the plurality of different specimens, respectively, and displaying the estimated onset site on the three-dimensional prostate image. may include more.
- the step of specifying the putative binding disease site based on the plurality of disease sites included in each of the plurality of different specimens may include: When it is determined that the individual disease site and the second individual disease site satisfy a predetermined binding criterion, specifying a tissue between the first individual disease site and the second individual disease site as the estimated disease site may be included. .
- the binding criterion is that the first individual disease site and the second individual disease site corresponding to each of the first and second specimens satisfy a proximity criterion according to a predetermined criterion, or the first individual disease site and the first individual disease site It may be characterized in that it is determined that the two individual disease sites satisfy a predetermined continuity criterion.
- the step of specifying the relative onset location in the sample of the prostate cancer onset site present in the sample for each sample based on the digital diagnosis result includes a sample pathology image of the sample displayed in the digital diagnosis result and within the sample displayed on the sample pathology image.
- the method may include specifying a relative onset location in the sample based on the location of the prostate onset site.
- the step of the three-dimensional prostate pathology image generating system specifying the position of the specimen for each specimen on the three-dimensional prostate image based on the template coordinates for each specimen is based on the position of the needle on the ultrasound image obtained in the transperineal template prostate biopsy process. to specify the position of the needle on the three-dimensional prostate image, and specifying the position of the specimen for each specimen based on the position of the needle on the three-dimensional prostate image and the position of a predetermined specimen collection unit on the needle. have.
- the method may be implemented by a computer program stored in a computer-readable recording medium.
- a three-dimensional prostate pathology image generating system includes a processor and a memory in which a program executed by the processor is recorded, and the processor drives the program to specify a three-dimensional prostate image, and diagnosis At least one sample-specific digital diagnosis result corresponding to a predetermined template coordinate obtained through Transperineal Template Prostate Biopsy (TTPB) is obtained through the system, and the sample-specific template coordinate and the digital diagnosis result are obtained. Based on the at least one specimen, an onset site of prostate cancer present in the at least one specimen is displayed on the three-dimensional prostate image.
- TTPB Transperineal Template Prostate Biopsy
- the processor drives the program to specify the position of the specimen for each specimen on the three-dimensional prostate image on the basis of the template coordinates for each specimen, and based on the digital diagnosis result, within the specimen at the prostate cancer site existing in the specimen for each specimen.
- the relative location of onset can be specified.
- the processor may drive the program to specify an estimated onset site based on a plurality of onset sites respectively included in the plurality of different specimens, and display the estimated onset site on the three-dimensional prostate image.
- a tissue between the first individual disease site and the second individual disease site may be specified as the estimated disease site.
- the binding criterion is that the first individual disease site and the second individual disease site corresponding to each of the first and second specimens satisfy a proximity criterion according to a predetermined criterion, or the first individual disease site and the first individual disease site It may be a case where it is determined that two individual disease sites satisfy a predetermined continuity criterion.
- the processor may drive the program to specify the relative onset location in the sample based on the sample pathology image of the sample displayed on the digital diagnosis result and the location of the prostate onset site in the sample displayed on the sample pathology image.
- the processor drives the program to specify the position of the needle on the three-dimensional prostate image based on the position of the needle on the ultrasound image obtained in the transperineal template prostate biopsy process, and the position of the needle on the three-dimensional prostate image and the position of the specimen for each specimen may be specified based on the predetermined position of the specimen collection unit on the needle.
- the position of the specimen collected through biopsy on the three-dimensional image of the prostate and the position of the expression of prostate cancer in the test result of the specimen are visualized relatively accurately, which can be usefully used for subsequent diagnosis and treatment, prognosis, etc. It works.
- 1 is a diagram for explaining the concept of a transperineal template prostate biopsy.
- FIG. 2 is a view for explaining the transperineal template prostate biopsy in more detail.
- FIG. 3 shows a schematic system configuration for implementing a method for generating a three-dimensional prostate pathology image according to an embodiment of the present invention.
- FIG. 4 shows a schematic configuration of a three-dimensional prostate pathology image generating system according to an embodiment of the present invention.
- FIG. 5 is a diagram illustrating a three-dimensional prostate image according to an embodiment of the present invention.
- FIG. 6 is a view for explaining a method of expressing the location of the specimen and the cancer site on a three-dimensional prostate image according to an embodiment of the present invention.
- FIG. 7 is a diagram illustrating positions of a plurality of specimens on a three-dimensional prostate image according to an embodiment of the present invention.
- FIG. 8 is a diagram for explaining an estimated onset site according to an embodiment of the present invention.
- FIG. 9 is a view for explaining a binding site according to an embodiment of the present invention.
- the component when any one component 'transmits' data to another component, the component may directly transmit the data to the other component or through at least one other component. This means that the data may be transmitted to the other component. Conversely, when one component 'directly transmits' data to another component, it means that the data is transmitted from the component to the other component without passing through the other component.
- 1 is a diagram for explaining the concept of a transperineal template prostate biopsy.
- FIG. 2 is a view for explaining in more detail a transperineal template prostate biopsy.
- FIG. 1 shows a conventionally known transperineal template prostate biopsy method.
- a needle is injected through the rectum in a conventional transrectal prostate biopsy, but the position of the needle is determined by the sample.
- the method arbitrarily determined by the collector it is a method of injecting the needle through the perineum after fixing the position of the needle relatively accurately through a fixing mechanism for the position of the needle called a template.
- the needle is injected while checking one section of the prostate through the ultrasound probe injected through the rectum, and the needle is injected up to the area suspected of prostate cancer, and a sample of a predetermined size to collect
- the drawing shown on the left shows a view when the examiner (the person who collects the sample) looks at the template 10 from the front
- the drawing shown on the right shows the needle injection from the side of the examiner
- a plurality of injection holes are fixedly formed in the template 10 , and an identifier for identifying the plurality of injection holes may be assigned.
- the identifier of each injection hole is defined as template coordinates, and the left and right top and bottom positions in the front view of the prostate into which the needle is injected, that is, the position on the x, y plane, can be specified by the template coordinates.
- the examiner may select template coordinates suitable for a portion where it is determined that it is necessary to take a specimen through an ultrasound image obtained through the ultrasound probe 20 , and inject the sample collection needle 20 into the selected template coordinates.
- this transperineal template prostate biopsy method also specifies the x and y coordinates in the front view (eg, the left view of FIG. 2 ) of the template 10, but the specimen collected in the front view is measured in the depth direction of the prostate (eg, There is a problem in that it is difficult to specify which part in the left and right direction in the right drawing of FIG. 2), and even if the depth direction can be known, when cancer is expressed in a specific part of the sample as a result of diagnosis of the sample taken, the specific part is There was a problem that it was not possible to know what position it was in the entire prostate.
- the expression location of the cancer is relative to the three-dimensional prostate image. It is possible to provide a method and a system that can be accurately mapped to not only visually and easily check the test results, but also be usefully used for treatment.
- the three-dimensional prostate pathology image generation method when one or more samples are collected from the prostate through a transperineal template prostate biopsy and the test is performed, it is not limited to simply checking whether cancer is expressed in the sample, It is possible to specify in which region the cancer is expressed in the sample and display it on a three-dimensional prostate image.
- the location at which cancer is expressed can be determined relatively accurately even in a sample, when multiple samples are collected, it is possible that cancer has been expressed even though the sample is not actually sampled based on the expression location of each cancer in the plurality of samples. It is possible to provide an effect that can be visualized by rationally predicting this high position.
- a three-dimensional prostate pathology image generating system according to the technical idea of the present invention for implementing the technical idea will be described with reference to FIGS. 3 and 4 .
- FIG. 3 shows a schematic system configuration for implementing a method for generating a three-dimensional prostate pathology image according to an embodiment of the present invention.
- 4 shows a schematic configuration of a three-dimensional prostate pathology image generating system according to an embodiment of the present invention.
- a three-dimensional prostate pathology image generating system 100 may be provided to implement the three-dimensional prostate pathology image generating method according to the technical idea of the present invention.
- the three-dimensional prostate pathology image generating system (hereinafter, 'generating system', 100 ) may implement the technical idea of the present invention while communicating with a predetermined diagnosis system 200 .
- the generating system 100 receives the test result of the sample from the diagnosis system 200, and maps the location of the sample and the cancer expression location on the three-dimensional prostate image based on the received test result as described above. can be displayed
- the diagnosis system 200 may be a system that receives a pathological image (eg, a tissue image) of a specimen and determines in which region the prostate cancer is expressed.
- a pathological image eg, a tissue image
- the diagnosis system 200 determines the expression site of cancer on the entire digital image of the specimen, that is, a slide image or a patch image in which the slide image is divided into a plurality of patches through deep learning-based image analysis to determine the location of the expression site. It may be a system that displays on an image or outputs the location of the cancer expression site.
- An example of such a diagnosis system 200 is a Korean patent application filed by the present applicant (application number 10-2016-0168176, a system and method for diagnosis of disease using a neural network), (application number 10-2018-0064332, two Pace disease diagnosis system and method), etc., and in addition, various diagnostic methods for receiving a digital image of a tissue and specifying an onset site of cancer through a deep learning-based diagnostic model are known.
- diagnosis system 200 itself is omitted to clarify the gist of the present invention, but a digital image of a specimen to be tested is input and the onset site of prostate cancer is specified on the digital image.
- An average expert in the technical field of the present invention can easily infer that various methods can be implemented with the diagnosis system 200 .
- diagnosis system 200 may receive from the examiner the injection hole of the sample collected by the examiner, that is, the template coordinates, and the diagnosis system 200 provides the template coordinates and the digital diagnosis result of the sample corresponding to the template coordinates. It can be transmitted to the generation system 100 .
- the diagnostic system 200 may be provided with a tool for generating a digital image of the sample by photographing or scanning the sample, or may receive a digital image through the tool.
- the digital diagnosis result of the specimen may be a pathological image itself in which an onset site of prostate cancer is marked on a digital image corresponding to the specimen.
- the generation system 100 may analyze the pathological image to specify the location (eg, coordinate values, etc.) of the cancer site.
- the diagnosis system 200 may specify at least one coordinate value that may indicate an expression site of prostate cancer on the digital image of the specimen and transmit it to the generation system 100 .
- these coordinate values can be used as relative positions indicating the site of the prostate cancer in the sample.
- information eg, Gleason score
- the generation system 100 may In addition to the location of the cancer expression site on the three-dimensional prostate image, it is also possible to differentially visualize the corresponding area according to the progress of the prostate cancer.
- the generation system 100 may receive the template coordinates for each specimen and the digital diagnosis result corresponding to the specimen, and specify the position of the corresponding specimen on the 3D prostate image based on the received template coordinates for each specimen.
- the position of the specimen on the three-dimensional prostate image may be specified as x and y positions on the front view of the template 10 based on template coordinates for each specimen.
- the position in the depth direction may be estimated based on the length of the needle and the position of the sieving part formed on the needle to collect a specimen.
- an ultrasound image in a state in which the needle is injected may be analyzed.
- the generating system 100 may additionally receive an ultrasound image in a state in which the needle is injected, and may specify the outer portion of the prostate and the position of the end of the needle in the ultrasound image through image analysis.
- the position of the needle analyzed in the ultrasound image is converted to the position on the three-dimensional prostate image, and the position in the depth direction of the injected needle can be determined relatively accurately.
- the position of the specimen finally collected on the three-dimensional prostate image may be specified based on the position of the formed specimen collection part.
- the generation system 100 may identify information on the relative position of the onset site of prostate cancer and/or the degree of cancer progression in the specimen based on the digital diagnosis result of the diagnosis system 200 .
- the cancer site in the sample may be finally specified and displayed on the three-dimensional prostate image.
- the diagnosis result diagnosed through the transperineal template prostate biopsy can be visualized on the three-dimensional prostate image.
- the prostate is not actually collected. It is also possible to estimate whether or not cancer has developed. That is, the estimated disease site may be calculated and provided.
- a specific configuration of the generation system 100 for providing such a technical idea may be as shown in FIG. 4 .
- the generation system 100 includes a processor 110 and a storage medium (or memory, 120) for implementing the functions defined herein as shown in FIG. 2 .
- the processor 110 may mean an arithmetic device capable of executing a predetermined program (software code), and may include an implementation example of the data processing device or a vendor mobile processor, microprocessor, CPU, single processor, multiprocessor, It may be named by various names such as GPU, and may be implemented by one or more processors.
- An average expert in the technical field of the present invention can easily infer that the processor 110 can perform data processing necessary for the technical idea of the present invention by driving the program.
- the memory 120 may refer to a device in which a program for implementing the technical idea of the present invention is stored/installed. According to an embodiment, the memory 120 may be divided into a plurality of different physical devices, and according to an embodiment, a part of the memory 120 may exist inside the processor 110 .
- the memory 120 may be implemented as a hard disk, a GPU, a solid state disk (SSD), an optical disk, a random access memory (RAM), and/or other various types of storage media, depending on the embodiment. may be implemented in the memory 120 in a removable manner.
- the generating system 100 may be implemented as an independent physical device for implementing the three-dimensional prostate pathology image generating method according to the technical idea of the present invention while communicating with the diagnosis system 200, but is not limited thereto. It may be implemented by any data processing device (eg, computer, mobile terminal, etc.) having data processing capability to execute the program.
- data processing device eg, computer, mobile terminal, etc.
- the generation system 100 may be mounted on the diagnosis system 200 and may be physically integrated with the diagnosis system 200 .
- the generation system 100 includes various peripheral devices (eg, input/output device, display device, audio device, etc., 140 included in the processor 110 , the memory 120 , and the diagnostic control system 100 ). , 141) and a communication interface (eg, a communication bus, 130, etc.) for connecting these devices may be provided, as an average expert in the art of the present invention can easily infer.
- peripheral devices eg, input/output device, display device, audio device, etc., 140 included in the processor 110 , the memory 120 , and the diagnostic control system 100 .
- a communication interface eg, a communication bus, 130, etc.
- the generation system 100 can be implemented by organically combining the program (or software) stored in the memory 120 and the processor 110 .
- An average expert in the art of the present invention can easily infer that the function and/or operation performed by the generation system 100 in the specification can be achieved by executing the program by the processor 110 .
- FIG. 5 is a diagram illustrating a three-dimensional prostate image according to an embodiment of the present invention.
- 5A and 5B respectively show a three-dimensional prostate image and a front view of the template 10, the generating system 100 may specify such a three-dimensional prostate image and, if necessary, visualize a cross-section in a desired direction. .
- the three-dimensional prostate image may be received by the generation system 100 from the outside or may be generated by the generation system 100 itself.
- a three-dimensional image of the prostate of the examinee may be generated through techniques such as CT 3D and/or multiparametric magnetic resonance image (mpMRI).
- the generation system 100 may schematically display, ie, an estimated cancer expression site, on the generated three-dimensional image using information obtained through a predetermined diagnostic method (eg, ultrasound examination, mpMRI, etc.).
- a predetermined diagnostic method eg, ultrasound examination, mpMRI, etc.
- the examiner may perform a transperineal template prostate biopsy as described above on the predicted site.
- a sample collected through the transperineal template prostate biopsy may be diagnosed through the diagnostic system 200 .
- the diagnosis system 200 may determine an onset site of prostate cancer in a specimen for each specimen, and transmit a digital diagnosis result to the generation system 100 .
- template coordinates of each specimen may be input to the diagnosis system 200 .
- the generation system 100 may specify and visualize the location of the sample and/or the site of cancer on the three-dimensional prostate image based on the received diagnostic results for each sample.
- FIG. 6 is a view for explaining a method of expressing the location of the specimen and the cancer site on a three-dimensional prostate image according to an embodiment of the present invention.
- FIG. 6A shows a view in the case of performing a transperineal template prostate biopsy through a needle 20 from the side based on the template 10.
- the The needle 20 may be inserted into the injection hole corresponding to the template coordinates, and the needle 20 may reach a predetermined position in the prostate.
- the specimen collection unit formed at a predetermined position (eg, from 21 to 22) of the needle 20 may collect a specimen by a predetermined length in the longitudinal direction of the needle.
- the collected specimen may be converted into a digital pathology image by the diagnosis system 200 or through a separate external device.
- the diagnosis system 200 receiving the converted digital pathology image and template coordinates may generate a digital diagnosis result.
- An example of the generated digital diagnosis result may be as shown in FIG. 6B .
- 6B exemplarily illustrates a case in which the onset site of prostate cancer is visualized in yellow and orange in the digital pathology image of the sample in the pink portion.
- the regions visualized in yellow and orange may be visualized in different colors in order to distinguish different degrees of progression of prostate cancer, respectively.
- the digital diagnosis result may be an image in which the onset site of prostate cancer is visualized in the digital pathology image of the specimen, or it corresponds to the coordinate value for each pixel and each coordinate value corresponding to the onset site of the prostate cancer on the digital pathology image. It may also be a degree of progress (eg, Gleason score).
- the digital diagnosis result may include information for specifying which location on the digital pathological image of the specimen is the site of the prostate cancer.
- the generation system 100 can specify the relative onset location (eg, Ct to Cb) of the prostate cancer within the entire length (eg, Xt to Xb) of the specimen as shown in FIG. 6C .
- the relative onset location in the sample may be a starting location (Ct) and a species unit value (Cb) that can specify the location of prostate cancer in the sample as shown in FIG. 6C, or the sample
- the coordinate values of pixels corresponding to the onset site may themselves be relative onset positions.
- any information that can specify the location of the onset site in the sample on the three-dimensional prostate image may be the relative onset location.
- the position of the specimen can be specified according to the template coordinates, the position in the depth direction of the needle 20, and the position of the specimen collection unit in the needle, as described above.
- the position in the depth direction of the needle 20 may be calculated as a rough estimate based on how far the needle has entered with respect to the template 10, but as described above, through the ultrasound image obtained when the sample is collected.
- the position of the needle 20 may be determined by the generating system 100 .
- the position in the depth direction of the needle 20 on the three-dimensional image can be determined in more detail by analyzing the difference in distance between the periphery of the prostate and the end of the needle 20 in the ultrasound image.
- the onset site 40 of prostate cancer may be specified and visualized on the three-dimensional prostate image.
- the generating system 100 may simply visualize only the onset site of prostate cancer on the three-dimensional prostate image, but since it can also be important information for important diagnosis and treatment, the position 30 of the sample taken on the three-dimensional prostate image is displayed. You may.
- FIG. 6 shows a case in which the location 30 of the sample and/or the site of occurrence of prostate cancer 4 is visualized for any one sample
- the case may be as shown in FIG. 7 .
- FIG. 7 is a diagram illustrating positions of a plurality of specimens on a three-dimensional prostate image according to an embodiment of the present invention.
- five specimens may be collected at positions corresponding to different template coordinates, and in this case, positions 31, 32, 33, 34, 35 of the specimens When is visualized on a three-dimensional prostate image, it may be as shown in FIG. 7 .
- the generation system 100 may specify an onset site of prostate cancer for each specimen and visualize it.
- FIG. 8 is a diagram for explaining an estimated onset site according to an embodiment of the present invention.
- FIG. 8 is a simplified example of a case in which individual disease sites 41 , 42 , 43 , 44 in each specimen are visualized on a three-dimensional prostate image by the generation system 100 when a plurality of specimens are collected. are doing
- the generating system 100 may simply visualize the diseased regions 41 , 42 , 43 , and 44 for each of a plurality of specimens on a three-dimensional prostate image.
- the estimated disease site (eg, 50, 51, 52) is specified based on the plurality of disease sites (41, 42, 43, 44), and the estimated disease site (eg, 50, 51, 52) can be further visualized.
- prostate cancer can develop even in areas not detected through transperineal template prostate biopsy. This is because there are cases where there is a high possibility that prostate cancer has also occurred at the location, that is, the estimated onset site, and it can be very useful to visualize the estimated onset site as well.
- the generation system 100 visualizes the estimated onset site separately from the onset site by actual diagnosis, or the estimated onset site (50, 51, 52) and the actual onset site (41, 42, 43, 44).
- the binding site comprising a can be visualized by displaying it on a three-dimensional prostate image.
- the estimated disease site may be a site that satisfies a predetermined reference condition, that is, a binding criterion.
- the generation system 100 includes a first individual disease site (eg, 41) and a second individual disease site (eg, 42) corresponding to the first and second specimens, respectively, among the plurality of different specimens.
- the tissue (eg, 50) between the first individual disease site (eg, 41) and the second individual disease site (eg, 42) can be specified as the estimated disease site. have.
- the first individual diseased site (eg, 42) and the second individual diseased site (eg, 43) satisfy a predetermined binding criterion the first individual diseased site (eg, 42) and the second individual diseased site (eg, 42) A tissue (eg, 51) between the disease sites (eg, 43) may be specified as the putative disease site.
- the binding criterion may include a condition that the template coordinates corresponding to each of the first and second specimens satisfy an adjacency criterion determined by a predetermined criterion.
- Whether the location of the individual disease sites is adjacent may be simply determined based on the template coordinates of the sample corresponding to the individual disease sites, or may be determined based on the actual distance in three dimensions between the individual disease sites.
- the three-dimensional distance between the individual disease sites may be the distance between the center points of the individual disease sites, or may be the distance between the nearest outlines after specifying the outlines of the individual disease sites.
- the distance between the individual disease sites can be defined in various ways, and the degree to which they must be adjacent to satisfy the binding criterion may be determined in advance or through repeated experiments.
- the continuity criterion may be, for example, a case in which the disease progression status is the same or there is a difference within a predetermined range, such as, for example, the Gleason scores of two individual disease sites satisfying the proximity criterion are the same or there is only a difference of one degree.
- it may be a case where individual diseased regions satisfy a predetermined pattern shape. It is determined that the continuity criterion is satisfied when at least one of the pattern shapes can include two individual disease sites by learning a plurality of medical data from these pattern shapes to build a pattern for the shapes of the diseased site in advance. You may.
- Continuity criteria can be defined in a variety of ways.
- the combination criterion may be defined to be satisfied even if either one of the adjacency criterion or the continuity criterion is satisfied, or it may be defined that the association criterion is satisfied only when both criteria are satisfied.
- the onset site confirmed through actual diagnosis is not only visualized on the three-dimensional prostate image, but also the site with a high probability of onset based on the confirmed disease site and visualized by estimating and visualizing the confirmed disease site. It can be very useful.
- FIG. 9 is a view for explaining a binding site according to an embodiment of the present invention.
- FIG. 9 shows an example in which a combined onset site including an estimated onset site and an actual onset site is displayed on a three-dimensional prostate image according to the technical spirit of the present invention.
- the generation system 100 is Of course, it is also possible to visualize the onset site and the estimated onset site so that they can be distinguished.
- the method for generating a three-dimensional prostate pathology image can be implemented as computer-readable codes on a computer-readable recording medium.
- the computer-readable recording medium includes all types of recording devices in which data readable by a computer system is stored. Examples of the computer-readable recording medium include ROM, RAM, CD-ROM, magnetic tape, hard disk, floppy disk, and optical data storage device.
- the computer-readable recording medium is distributed in a computer system connected through a network, so that the computer-readable code can be stored and executed in a distributed manner. And functional programs, codes, and code segments for implementing the present invention can be easily inferred by programmers in the art to which the present invention pertains.
- the present invention can be applied to a method and system for generating a three-dimensional prostate pathology image.
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Abstract
Description
Claims (16)
- 삼차원 전립선 병리 이미지 생성시스템이 삼차원 전립선 이미지를 특정하는 단계;상기 삼차원 전립선 병리 이미지 생성시스템이, 진단 시스템을 통해 경회음부 템플릿 전립선 생검술(Transperineal Template Prostate Biopsy, TTPB)을 통해 획득된 소정의 템플릿 좌표에 해당하는 적어도 하나의 검체별 디지털 진단 결과를 획득하는 단계;상기 삼차원 전립선 병리 이미지 생성시스템이 검체별 템플릿 좌표와 상기 디지털 진단결과에 기초하여 상기 적어도 하나의 검체에 존재하는 전립선암의 발병부위를 상기 삼차원 전립선 이미지 상에서의 표시하는 단계를 포함하는 삼차원 전립선 병리 이미지 생성방법.
- 제1항에 있어서, 상기 삼차원 전립선 병리 이미지 생성시스템이 검체별 템플릿 좌표와 상기 디지털 진단결과에 기초하여 상기 적어도 하나의 검체에 존재하는 전립선암의 발병부위를 상기 삼차원 전립선 이미지 상에서의 표시하는 단계는,상기 삼차원 전립선 병리 이미지 생성시스템이 상기 검체별 템플릿 좌표에 기초하여 상기 삼차원 전립선 이미지 상에서 상기 검체별 검체 위치를 특정하는 단계; 및상기 디지털 진단 결과에 기초하여 검체별로 검체 내에 존재하는 전립선암 발병부위의 검체내 상대적 발병 위치를 특정하는 단계를 포함하는 삼차원 전립선 병리 이미지 생성방법.
- 제1항에 있어서, 상기 삼차원 전립선 병리 이미지 생성방법은,상기 삼차원 전립선 이미지 상에 상기 검체별 검체위치를 표시하는 단계를 더 포함하는 삼차원 전립선 병리 이미지 생성방법.
- 제1항에 있어서, 상기 삼차원 전립선 병리 이미지 생성방법은,상기 복수의 서로 다른 검체들에 각각 포함된 복수의 발병부위들에 기초하여 추정 발병부위를 특정하는 단계;상기 추정 발병부위를 상기 삼차원 전립선 이미지 상에 표시하는 단계를 더 포함하는 삼차원 전립선 병리 이미지 생성방법.
- 제4항에 있어서, 상기 복수의 서로 다른 검체들에 각각 포함된 복수의 발병부위들에 기초하여 추정 결합 발병부위를 특정하는 단계는,상기 복수의 서로 다른 검체들 중 제1검체와 제2검체 각각에 상응하는 제1개별 발병부위와 제2개별 발병부위가 소정의 결합기준을 만족한다고 판단된 경우, 상기 제1개별 발병부위와 상기 제2개별 발병부위 사이의 조직을 추정 발병부위로 특정하는 단계를 포함하는 삼차원 전립선 병리 이미지 생성방법.
- 제5항에 있어서, 상기 결합기준은,상기 제1검체와 상기 제2검체 각각에 상응하는 상기 제1개별 발병부위와 상기 제2개별 발병부위가 미리 정해진 기준에 따른 인접성 기준을 만족하거나 상기 제1개별 발병부위와 상기 제2개별 발병부위가 미리 정해진 연속성 기준을 만족한다고 판단되는 경우인 것을 특징으로 하는 삼차원 전립선 병리 이미지 생성방법.
- 제2항에 있어서, 상기 디지털 진단 결과에 기초하여 검체별로 검체 내에 존재하는 전립선암 발병부위의 검체내 상대적 발병 위치를 특정하는 단계는,상기 디지털 진단 결과에 표시된 검체의 검체 병리 이미지 및 상기 검체 병리 이미지 상에 표시된 검체 내 전립선 발병부위의 위치에 기초하여 상기 검체내 상대적 발병위치를 특정하는 단계를 포함하는 삼차원 전립선 병리 이미지 생성방법.
- 제2항에 있어서, 상기 삼차원 전립선 병리 이미지 생성시스템이 상기 검체별 템플릿 좌표에 기초하여 상기 삼차원 전립선 이미지 상에서 상기 검체별 검체 위치를 특정하는 단계는,상기 경회음부 템플릿 전립선 생검술 과정에서 획득되는 초음파 이미지상에서 니들의 위치에 기초하여 상기 삼차원 전립선 이미지 상에서 상기 니들의 위치를 특정하는 단계;상기 삼차원 전립선 이미지 상에서 상기 니들의 위치와 상기 니들 상에서 미리 정해진 검체 체취부의 위치에 기초하여 상기 검체별 검체위치를 특정하는 단계를 포함하는 삼차원 전립선 병리 이미지 생성방법.
- 데이터 처리장치에 설치되며 제1항 내지 제8항 중 어느 한 항에 기재된 방법을 수행하기 위한 컴퓨터 판독가능한 기록매체에 저장된 컴퓨터 프로그램.
- 프로세서; 및상기 프로세서에 의해 실행되는 프로그램이 기록된 메모리를 포함하며,상기 프로세서는 상기 프로그램을 구동하여,삼차원 전립선 이미지를 특정하고, 진단 시스템을 통해 경회음부 템플릿 전립선 생검술(Transperineal Template Prostate Biopsy, TTPB)을 통해 획득된 소정의 템플릿 좌표에 해당하는 적어도 하나의 검체별 디지털 진단 결과를 획득하며, 검체별 템플릿 좌표와 상기 디지털 진단결과에 기초하여 상기 적어도 하나의 검체에 존재하는 전립선암의 발병부위를 상기 삼차원 전립선 이미지 상에서의 표시하는 삼차원 전립선 병리 이미지 생성시스템.
- 제10항에 있어서, 상기 프로세서는 상기 프로그램을 구동하여,상기 검체별 템플릿 좌표에 기초하여 상기 삼차원 전립선 이미지 상에서 상기 검체별 검체 위치를 특정하고, 상기 디지털 진단 결과에 기초하여 검체별로 검체 내에 존재하는 전립선암 발병부위의 검체내 상대적 발병 위치를 특정하는 삼차원 전립선 병리 이미지 생성시스템.
- 제10항에 있어서, 상기 프로세서는 상기 프로그램을 구동하여,상기 복수의 서로 다른 검체들에 각각 포함된 복수의 발병부위들에 기초하여 추정 발병부위를 특정하고, 상기 추정 발병부위를 상기 삼차원 전립선 이미지 상에 표시하는 삼차원 전립선 병리 이미지 생성시스템.
- 제12항에 있어서, 상기 프로세서는 상기 프로그램을 구동하여,상기 복수의 서로 다른 검체들 중 제1검체와 제2검체 각각에 상응하는 제1개별 발병부위와 제2개별 발병부위가 소정의 결합기준을 만족한다고 판단된 경우, 상기 제1개별 발병부위와 상기 제2개별 발병부위 사이의 조직을 추정 발병부위로 특정하는 삼차원 전립선 병리 이미지 생성시스템.
- 제13항에 있어서, 상기 결합기준은,상기 제1검체와 상기 제2검체 각각에 상응하는 상기 제1개별 발병부위와 상기 제2개별 발병부위가 미리 정해진 기준에 따른 인접성 기준을 만족하거나 상기 제1개별 발병부위와 상기 제2개별 발병부위가 미리 정해진 연속성 기준을 만족한다고 판단되는 경우인 것을 특징으로 하는 삼차원 전립선 병리 이미지 생성시스템.
- 제11항에 있어서, 상기 프로세서는 상기 프로그램을 구동하여,상기 디지털 진단 결과에 표시된 검체의 검체 병리 이미지 및 상기 검체 병리 이미지 상에 표시된 검체 내 전립선 발병부위의 위치에 기초하여 상기 검체내 상대적 발병위치를 특정하는 단계를 삼차원 전립선 병리 이미지 생성시스템.
- 제11항에 있어서, 상기 프로세서는 상기 프로그램을 구동하여,상기 경회음부 템플릿 전립선 생검술 과정에서 획득되는 초음파 이미지상에서 니들의 위치에 기초하여 상기 삼차원 전립선 이미지 상에서 상기 니들의 위치를 특정하고, 상기 삼차원 전립선 이미지 상에서 상기 니들의 위치와 상기 니들 상에서 미리 정해진 검체 체취부의 위치에 기초하여 상기 검체별 검체위치를 특정하는 삼차원 전립선 병리 이미지 생성시스템.
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EP22750089.9A EP4276844A1 (en) | 2021-02-08 | 2022-02-08 | Method for generating three-dimensional prostate pathological image, and system therefor |
JP2023544721A JP2024505872A (ja) | 2021-02-08 | 2022-02-08 | 三次元前立腺病理画像生成方法及びそのシステム |
US18/276,039 US20240037855A1 (en) | 2021-02-08 | 2022-02-08 | Method for generating three-dimensional prostate pathological image, and system therefor |
CN202280013992.4A CN116830210A (zh) | 2021-02-08 | 2022-02-08 | 三维前列腺病理图像生成方法及其系统 |
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JP2015201108A (ja) * | 2014-04-09 | 2015-11-12 | 日本メディカルソリューションズ株式会社 | 診療録作成支援システム、サーバ装置、医療機関端末、診療録作成支援方法、医療機関装置及び診療録作成支援プログラム |
JP2016518150A (ja) * | 2013-03-15 | 2016-06-23 | ユーシー—ケア リミテッド. | 生検試料を処理するためのシステムおよび方法 |
KR20180064332A (ko) | 2018-04-30 | 2018-06-14 | 윤진원 | 조형재료의 분사 방향이 가변 가능한 3차원 프린터 |
JP2019153086A (ja) * | 2018-03-02 | 2019-09-12 | 富士フイルム株式会社 | 学習用データ作成支援装置、学習用データ作成支援方法、および学習用データ作成支援プログラム |
JP2020139842A (ja) * | 2019-02-28 | 2020-09-03 | ソニー株式会社 | 情報処理装置、情報処理方法および情報処理システム |
KR20200117222A (ko) * | 2019-04-03 | 2020-10-14 | 서울대학교병원 | 병리 진단 지원 장치 및 방법 |
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2021
- 2021-02-08 KR KR1020210017521A patent/KR20220115120A/ko unknown
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2022
- 2022-02-08 CN CN202280013992.4A patent/CN116830210A/zh active Pending
- 2022-02-08 US US18/276,039 patent/US20240037855A1/en active Pending
- 2022-02-08 JP JP2023544721A patent/JP2024505872A/ja active Pending
- 2022-02-08 WO PCT/KR2022/001884 patent/WO2022169340A1/ko active Application Filing
- 2022-02-08 EP EP22750089.9A patent/EP4276844A1/en active Pending
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JP2016518150A (ja) * | 2013-03-15 | 2016-06-23 | ユーシー—ケア リミテッド. | 生検試料を処理するためのシステムおよび方法 |
JP2015201108A (ja) * | 2014-04-09 | 2015-11-12 | 日本メディカルソリューションズ株式会社 | 診療録作成支援システム、サーバ装置、医療機関端末、診療録作成支援方法、医療機関装置及び診療録作成支援プログラム |
JP2019153086A (ja) * | 2018-03-02 | 2019-09-12 | 富士フイルム株式会社 | 学習用データ作成支援装置、学習用データ作成支援方法、および学習用データ作成支援プログラム |
KR20180064332A (ko) | 2018-04-30 | 2018-06-14 | 윤진원 | 조형재료의 분사 방향이 가변 가능한 3차원 프린터 |
JP2020139842A (ja) * | 2019-02-28 | 2020-09-03 | ソニー株式会社 | 情報処理装置、情報処理方法および情報処理システム |
KR20200117222A (ko) * | 2019-04-03 | 2020-10-14 | 서울대학교병원 | 병리 진단 지원 장치 및 방법 |
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CN116830210A (zh) | 2023-09-29 |
JP2024505872A (ja) | 2024-02-08 |
US20240037855A1 (en) | 2024-02-01 |
KR20220115120A (ko) | 2022-08-17 |
EP4276844A1 (en) | 2023-11-15 |
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