WO2022147925A1 - Patch for treating male erectile dysfunction and preparation method therefor - Google Patents
Patch for treating male erectile dysfunction and preparation method therefor Download PDFInfo
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- WO2022147925A1 WO2022147925A1 PCT/CN2021/088032 CN2021088032W WO2022147925A1 WO 2022147925 A1 WO2022147925 A1 WO 2022147925A1 CN 2021088032 W CN2021088032 W CN 2021088032W WO 2022147925 A1 WO2022147925 A1 WO 2022147925A1
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- patch
- extract
- spider
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- 201000001881 impotence Diseases 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 208000010228 Erectile Dysfunction Diseases 0.000 title claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 43
- 241000239290 Araneae Species 0.000 claims abstract description 40
- 239000000284 extract Substances 0.000 claims abstract description 36
- 239000003814 drug Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 235000008422 Schisandra chinensis Nutrition 0.000 claims abstract description 15
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 12
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- 229940079593 drug Drugs 0.000 claims abstract description 6
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- 230000007774 longterm Effects 0.000 abstract description 4
- 230000009986 erectile function Effects 0.000 abstract description 2
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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- A—HUMAN NECESSITIES
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/79—Schisandraceae (Schisandra family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Definitions
- the invention relates to the technical field of traditional Chinese medicines, and more particularly to a patch for treating erectile dysfunction in men and a preparation method thereof.
- Li Yao spider has the effect of invigorating qi and blood, adding essence and strengthening yang. It is mainly used to treat the symptoms of weak fire in the door of life, deficiency of kidney yang, impotence, impotence, cold in the lower yuan, cold essence and childlessness.
- the local people of the Li nationality in Hainan often roast spiders or make wine with spiders to keep fit and resist dampness.
- the habit of Li medicine spiders has been passed down for thousands of years, the Li people have no written language, and the inheritance mainly relies on word of mouth.
- the purpose of the present invention is to provide a patch for treating male erectile dysfunction and a preparation method thereof, so that the patch can be used in the lower navel of human body and can significantly improve male erectile dysfunction.
- the present invention provides the following technical solutions:
- a patch for the treatment of male erectile dysfunction the active drug of which is composed of the alcohol extract of Liyao spider and the water extract of Alisma, Poria, Schisandra, Bakuchi, dried ginger, and cinnamon and musk (artificial).
- the selected Liyao spider in the present invention is the Wuzhishan spider, which is a unique national geographical indication agricultural product in Wuzhishan, Hainan.
- the Wuzhishan spider is famous for its plumpness and delicious taste. It is crispy and delicious after baking and has a long aftertaste.
- the Li people in Hainan have a history of eating fried spiders, grilling spiders or making wine with spiders for thousands of years to nourish yin and strengthen yang and strengthen their bodies.
- Li nationality doctors use roasted spiders to reduce fire and drive away cold, strengthen yang and invigorate the kidneys, treat deficiency, and have a high social awareness.
- Modern research methods have found that Wuzhishan spiders are high in protein and rich in essential trace elements such as calcium, manganese, zinc, iron, etc., which are not only nutritious and delicious, but also have significant health care and therapeutic effects.
- the present invention uses Wuzhishan spider to cooperate with other traditional Chinese medicine components to jointly treat male erectile dysfunction:
- Alisma enter the kidney, spleen, diuretic water and dampness, long-term smart ears and eyes, prolong youth, used for the treatment of inner ear vertigo, dyslipidemia, nocturnal emission, fatty liver and diabetes, etc.
- Boenjing "maintains wind, cold and dampness, reduces thirst, nourishes the five internal organs, and replenishes qi.”
- Bielu "Tonic for deficiency and loss of five labors, in addition to fullness of the five internal organs, invigorating yin qi, stopping semen ejaculation, quenching thirst, and stranguria Lek, remove bladder and Sanjiao and stop water.”
- Poria cocos the dried sclerotia of Poria cocos (Schw.) Wolf, a fungus of Poriaaceae Efficacy, commonly used as an adjuvant for strengthening the spleen and tonifying qi deficiency.
- Schisandra chinensis the dried and ripe fruit of Schisandra chinensis (Turcz.) Baill. of Magnoliaceae .
- Psoralea is used in the treatment of impotence due to kidney deficiency, soreness and pain in the waist and knees, nocturnal emission, enuresis, frequent urination, dyspnea and cough due to deficiency.
- Cinnamon is suitable for guiding hundreds of medicines, warming the middle and invigorating the kidney, strengthening the muscles and bones, clearing the blood vessels, controlling all diseases, and nourishing the spirit.
- the parts by weight of each crude drug are 4-6 parts of Liyao spider, 15-25 parts of Alisma, 20-30 parts of Poria, 15-25 parts of Schisandra chinensis, 25-35 parts of psoralen, 3-7 parts of cinnamon servings, 1-3 servings of dried ginger and 0.5-1.5 servings of musk.
- the parts by weight of each crude drug are 5 parts of Liyao spider, 20 parts of Alisma, 25 parts of Poria, 20 parts of Schisandra, 30 parts of psoralen, 5 parts of cinnamon, 2 parts of dried ginger and 1 part of musk.
- the alcohol extract of Liyao spider is the extract after soaking in ethanol.
- the ethanol is 70-90% ethanol.
- the present invention also provides a preparation method of the patch, comprising:
- Step 1 Soak Liyao spider in ethanol to obtain an alcohol extract; Alisma, Poria, Schisandra, Bakuchi, and dried ginger water extraction and alcohol precipitation method to obtain a water extract; the water extract is combined with the alcohol extract and concentrated into an alcohol-free stream extract;
- Step 2 Add cinnamon and musk into the liquid extract, adjust it into a thick paste, and coat it on a patch base (such as bab ointment) to prepare a patch.
- a patch base such as bab ointment
- the alcohol extract is obtained by the following preparation method:
- Liyao spider freeze-dried powder is soaked in 10-30 times the amount of 70-90% ethanol at room temperature for 24-72 hours, and the operation is performed one or more times. After completion, the extracts are combined to obtain an alcohol extract.
- the water extract is obtained by the following preparation method:
- Alisma, Poria, Schisandra, Psoralea, dried ginger add ten times the amount of water, heat and boil to extract one or more times for 1-3 hours each time, combine the medicinal liquids, concentrate; add 70-90% ethanol, stir to carry out Alcohol precipitation to obtain water extract.
- the present invention reduces any medicinal material of Wuzhishan spider, Schisandra chinensis or Psoralea, and finds that after the medicinal material is deleted, the clinical test effect is significantly worse than that of the test group.
- the Wuzhishan spider in the formula was replaced with commonly used aphrodisiac herbs such as epimedium or velvet antler. It may be because the herbs of epimedium and velvet antler are more suitable for oral nourishment, so the clinical effect of the control patch was not significant. enhanced.
- the present invention on the basis of arranging and improving the folk prescriptions related to Liyao spider, uses current research methods, and according to the principle of synergistic promotion of traditional Chinese medicine, the monarch, ministers, assistants and envoys, is compatible with other Chinese medicinal materials such as tuckahoe and musk, and provides a kind of medicine.
- the navel patch containing Liyao spider which is used to treat male erectile dysfunction and improve male sperm motility and quality, can effectively improve male erectile function and at the same time avoid the serious physical and mental burden caused by long-term oral medication, especially western medicine.
- the invention discloses a patch for treating male erectile dysfunction and a preparation method thereof, and those skilled in the art can learn from the content of this article and appropriately improve process parameters to achieve. It should be particularly pointed out that all similar substitutions and modifications are obvious to those skilled in the art, and they are deemed to be included in the present invention.
- the patch of the present invention and its preparation method have been described through the preferred embodiments, and it is obvious that relevant persons can make changes or appropriate changes to the patch and its preparation method without departing from the content, spirit and scope of the present invention and combinations to implement and apply the technology of the present invention.
- the navel is the Shenque Yang point on the Ren meridian of the human body.
- the acupoint is the gateway of the soul, so it has the functions of returning Yang to save the evil, clearing the orifices and Su Jue, regulating the health care of the Shenque acupoint, which can regulate the qi and blood of the Baimai, full of energy, strong physical strength, strong psoas muscle, ruddy complexion, bright ears and eyesight, light body and prolong life. . It has a unique curative effect on abdominal pain, edema and swelling, dysentery and prolapse of the anus, and stroke and apoplexy. The human body will be healthy and disease-free and youthful.
- the patch provided by the invention is used for the subumbilical Guanyuan, and the medicinal effect of the patch acts on the Ren vessel, thereby achieving the effect of significantly improving male erectile dysfunction.
- the raw materials used in each treatment group of the provided comparative test are the same, and the other test conditions are the same in each group except for due differences.
- the raw materials, reagents, etc. involved in the present invention can be obtained through commercial channels unless otherwise specified.
- Wuzhishan spider freeze-dried powder 5 parts (5g), Alisma 20 parts (20g), Poria 25 parts (25g), Schisandra 20 parts (20g), psoralen 30 parts (30g), cinnamon 5 parts (5g), dried 2 parts (2g) of ginger, 1 part (1g) of musk (artificial);
- the spider freeze-dried powder was soaked in 20 times the amount of 80% ethanol at room temperature for 48 hours, and the operation was performed twice. After completion, the extracts were combined.
- 2Other medicinal materials except musk and cinnamon
- extract with water add ten times the amount of water, heat and boil for extraction twice, each time for 1.5 hours, combine the medicinal liquids, and concentrate to a relative density of 1.2; add 70% ethanol, stir and add slowly, Stir for 30 minutes.
- the alcohol precipitation tank jacket was cooled with cooling water, and allowed to stand for 48 hours; the supernatant was combined with the spider extract, and concentrated to no alcohol.
- the relative density is 1.12, resulting in about 100 ml of liquid.
- Cinnamon is crushed into very fine powder (the "Chinese Pharmacopoeia” (2015 edition) stipulates that it can all pass through the No. 6 sieve, and contains no less than 95% of the powder that can pass the No. 7 sieve), and musk is added into the liquid extract to adjust. For thick paste.
- the effective rate of the navel patch of the present invention can reach 90% for the treatment of male erectile dysfunction, the curative effect is remarkable, and no adverse reaction is found.
- the clinical test effect (comparison group 1, comparison group 2, and comparison group 3) was significantly worse than that of the experimental group.
- the commonly used aphrodisiac herbs such as epimedium and deer antler were used to replace Wuzhishan spider, probably because the herbs of epimedium and deer antler are more suitable for oral nourishment, so they were made into patches. ) was also significantly worse than the experimental group.
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Abstract
A patch for treating male erectile dysfunction and a preparation method therefor. The patch comprises the following active ingredients: an alcohol extract of Li medicine spider, water extracts of Alismatis rhizoma, Poria, Schisandra chinensis, Fructus psoraleae and Zingiberis rhizoma, and Cinnamomi cortex and Moschus. According to the principle "principal, assistant, complement and mediating guide" in traditional Chinese medicine, the Li medicine spider is combined with other traditional Chinese medicines such as Poria and Moschus, so as to obtain a navel patch for treating male erectile dysfunction and improving male sperm motility and quality. The patch can effectively improve the male erectile function, and can also avoid the serious physical and psychological burden caused by long-term oral administration of medicines, especially western medicines.
Description
本申请要求于2021年01月07日提交中国专利局、申请号为202110018542.1、发明名称为“一种治疗男性勃起障碍的贴剂及其制备方法”的中国专利申请的优先权,其全部内容通过引用结合在本申请中。This application claims the priority of the Chinese patent application with the application number 202110018542.1 and the invention titled "A patch for treating male erectile dysfunction and its preparation method", which was submitted to the China Patent Office on January 7, 2021, the entire contents of which are approved by Reference is incorporated in this application.
本发明涉及中药技术领域,更具体的说是涉及一种治疗男性勃起障碍的贴剂及其制备方法。The invention relates to the technical field of traditional Chinese medicines, and more particularly to a patch for treating erectile dysfunction in men and a preparation method thereof.
随着生活节奏的不断加快、空气污染、不良的生活习惯以及遗传等因素影响,我国男性机体容易疲劳过度,进而导致性功能障碍日益严重,人群日益增多。男性性功能障碍主要表现为阳痿和早泄,同时伴有精子少、活力不足等导致不孕、难孕等现象,严重影响生活质量。传统治疗男性功能障碍的药物主要以西药为主,见效快,但副作用或不良反应较多,长期服用,对健康会造成较大负担。With the continuous acceleration of the pace of life, air pollution, bad living habits, genetics and other factors, the male body in my country is prone to excessive fatigue, which leads to increasingly serious sexual dysfunction and an increasing number of people. Male sexual dysfunction is mainly manifested as impotence and premature ejaculation, accompanied by low sperm and insufficient vitality, which lead to infertility and infertility, which seriously affect the quality of life. Traditional medicines for male dysfunction are mainly western medicines, which are quick to take effect, but have many side effects or adverse reactions. Long-term use will cause a greater burden on health.
黎药蜘蛛具有补气益血、添精壮阳之效,主治命门火弱、肾阳亏虚、阳痿不兴、下元虚寒、精冷无子等证。海南黎族当地人民常通过烤蜘蛛或者蜘蛛泡酒,来强身健体,抵御湿邪。虽然黎药蜘蛛的习用历经千年传承,但黎族没有文字,传承主要依靠口口相传,经典的验方散落民间不成体系,也并无科学系统的研究基础和临床试验基础。Li Yao spider has the effect of invigorating qi and blood, adding essence and strengthening yang. It is mainly used to treat the symptoms of weak fire in the door of life, deficiency of kidney yang, impotence, impotence, cold in the lower yuan, cold essence and childlessness. The local people of the Li nationality in Hainan often roast spiders or make wine with spiders to keep fit and resist dampness. Although the habit of Li medicine spiders has been passed down for thousands of years, the Li people have no written language, and the inheritance mainly relies on word of mouth.
发明内容SUMMARY OF THE INVENTION
有鉴于此,本发明的目的在于提供一种治疗男性勃起障碍的贴剂及其制备方法,使得所述贴剂用于人体肚脐下关元并能够显著改善男性勃起障碍。In view of this, the purpose of the present invention is to provide a patch for treating male erectile dysfunction and a preparation method thereof, so that the patch can be used in the lower navel of human body and can significantly improve male erectile dysfunction.
为实现上述发明目的,本发明提供如下技术方案:To achieve the above-mentioned purpose of the invention, the present invention provides the following technical solutions:
一种治疗男性勃起障碍的贴剂,其活性药物由黎药蜘蛛醇提物和泽泻、茯苓、五味子、补骨脂、干姜五味药的水提物,以及肉桂和麝香(人工)组成。A patch for the treatment of male erectile dysfunction, the active drug of which is composed of the alcohol extract of Liyao spider and the water extract of Alisma, Poria, Schisandra, Bakuchi, dried ginger, and cinnamon and musk (artificial).
本发明所选用的黎药蜘蛛为海南五指山特有的国家地理标志农产品—五指山蜘蛛。五指山蜘蛛做为黎族先民图腾和民间传承验方,以肥硕、味美而著名,经烘烤后酥脆可口,回味悠长,具有数千年悠久的人文历史和食用、药用传统。海南黎族食用油炸蜘蛛、烧烤蜘蛛或利用蜘蛛泡酒有上千年的历史,滋阴壮阳,强壮身体。黎族医生用烤蜘蛛降火驱寒,壮阳补肾,治疗亏虚,社会认知度较高。现代研究手段发现,五指山蜘蛛高蛋白质,并富含钙、锰、锌、铁等人体必需微量元素,不但营养美味,而且具有显著的保健、治疗功效。The selected Liyao spider in the present invention is the Wuzhishan spider, which is a unique national geographical indication agricultural product in Wuzhishan, Hainan. As a totem of the ancestors of the Li nationality and a folk heritage recipe, the Wuzhishan spider is famous for its plumpness and delicious taste. It is crispy and delicious after baking and has a long aftertaste. The Li people in Hainan have a history of eating fried spiders, grilling spiders or making wine with spiders for thousands of years to nourish yin and strengthen yang and strengthen their bodies. Li nationality doctors use roasted spiders to reduce fire and drive away cold, strengthen yang and invigorate the kidneys, treat deficiency, and have a high social awareness. Modern research methods have found that Wuzhishan spiders are high in protein and rich in essential trace elements such as calcium, manganese, zinc, iron, etc., which are not only nutritious and delicious, but also have significant health care and therapeutic effects.
同时,它也是地方道地药材,祛湿消炎解毒,补益肾阳,入药能够治疗风湿骨痛、中风口斜等多种疾病,且“山生者倍大”,各种县志及医药典籍等均有记载。海南黎族人民自古就有通过食用烤蜘蛛或蜘蛛泡酒等方式祛风除湿,强健身体;五指山当地黎医也有以蜘蛛为君药,用于治疗痛风、风湿、关节肿痛、颈腰酸痛等疾病,疗效得到了当地患者的高度认可;但将其用于肚脐下关元贴剂尚未见相关记载。At the same time, it is also a local and authentic medicinal material, which dispels dampness, reduces inflammation and detoxifies, and nourishes kidney yang. It can be used as medicine to treat various diseases such as rheumatism, bone pain, stroke, and oblique mouth. There are records. Since ancient times, the Li people of Hainan have used roasted spiders or spider wine to expel wind and dehumidify to strengthen their body; local Li doctors in Wuzhishan also use spiders as their king medicine to treat gout, rheumatism, joint swelling and pain, neck and waist pain and other diseases , the curative effect has been highly recognized by local patients; but there is no relevant record for its use in the navel Xiaguanyuan patch.
本发明以五指山蜘蛛配合其他中药组分共同治疗男性勃起障碍:The present invention uses Wuzhishan spider to cooperate with other traditional Chinese medicine components to jointly treat male erectile dysfunction:
泽泻,入肾、脾,利水渗湿,久耳目聪明、延年轻身,用于治疗内耳眩晕症、血脂异常、遗精、脂肪肝及糖尿病等。《本经》:"主风寒湿痹,消渴,养五脏,益气力。"《别录》:"补虚损五劳,除五脏痞满,起阴气,止泄精、消渴、淋沥,逐膀胱、三焦停水。"Alisma, enter the kidney, spleen, diuretic water and dampness, long-term smart ears and eyes, prolong youth, used for the treatment of inner ear vertigo, dyslipidemia, nocturnal emission, fatty liver and diabetes, etc. "Benjing": "maintains wind, cold and dampness, reduces thirst, nourishes the five internal organs, and replenishes qi." "Bielu": "Tonic for deficiency and loss of five labors, in addition to fullness of the five internal organs, invigorating yin qi, stopping semen ejaculation, quenching thirst, and stranguria Lek, remove bladder and Sanjiao and stop water."
茯苓,多孔菌科真菌茯苓Poria cocos(Schw.)Wolf的干燥菌核,药性平和,益脾逐水,生津导气,对于脾虚运化失常所致泄泻、带下等症,有标本兼顾的功效,常用做健脾,补气虚的辅佐药。Poria cocos, the dried sclerotia of Poria cocos (Schw.) Wolf, a fungus of Poriaaceae Efficacy, commonly used as an adjuvant for strengthening the spleen and tonifying qi deficiency.
五味子,为木兰科植物五味子Schisandra chinensis(Turcz.)Baill.的干燥成熟果实,收敛固涩,益气生津,补肾宁心,常用于梦遗滑精,久泻不止,自汗盗汗,津伤口渴等。Schisandra chinensis, the dried and ripe fruit of Schisandra chinensis (Turcz.) Baill. of Magnoliaceae .
补骨脂,归肾、脾经,补肾壮阳,固精缩尿,用于治疗肾虚阳痿、腰膝酸软冷痛、遗精遗尿尿频、虚寒喘咳等。Psoralea is used in the treatment of impotence due to kidney deficiency, soreness and pain in the waist and knees, nocturnal emission, enuresis, frequent urination, dyspnea and cough due to deficiency.
肉桂,宜导百药,温中补肾,坚筋骨,通血脉,主百病,养精神。Cinnamon is suitable for guiding hundreds of medicines, warming the middle and invigorating the kidney, strengthening the muscles and bones, clearing the blood vessels, controlling all diseases, and nourishing the spirit.
麝香,归心、脾经,开窍醒神,活血通经,消肿止痛,主治疮疡肿毒、瘰疬痰核,咽喉肿痛、跌打损伤,风寒湿痹等。Musk, returning to the heart and spleen meridians, opening the orifices and refreshing the mind, promoting blood circulation and clearing the meridians, reducing swelling and relieving pain, mainly treating sore, swollen toxin, scrofula and phlegm nucleus, sore throat, traumatic injury, wind-cold-dampness arthralgia, etc.
作为优选,各原料药的重量份数为黎药蜘蛛4-6份、泽泻15-25份、茯苓20-30份、五味子15-25份、补骨脂25-35份、肉桂3-7份、干姜1-3份和麝香0.5-1.5份。Preferably, the parts by weight of each crude drug are 4-6 parts of Liyao spider, 15-25 parts of Alisma, 20-30 parts of Poria, 15-25 parts of Schisandra chinensis, 25-35 parts of psoralen, 3-7 parts of cinnamon servings, 1-3 servings of dried ginger and 0.5-1.5 servings of musk.
在本发明具体实施方式中,各原料药的重量份数为黎药蜘蛛5份、泽泻20份、茯苓25份、五味子20份、补骨脂30份、肉桂5份、干姜2份和麝香1份。In a specific embodiment of the present invention, the parts by weight of each crude drug are 5 parts of Liyao spider, 20 parts of Alisma, 25 parts of Poria, 20 parts of Schisandra, 30 parts of psoralen, 5 parts of cinnamon, 2 parts of dried ginger and 1 part of musk.
作为优选,所述黎药蜘蛛醇提物为其乙醇浸泡后的提取液。在本发明具体实施方式中,所述乙醇为70-90%乙醇。Preferably, the alcohol extract of Liyao spider is the extract after soaking in ethanol. In a specific embodiment of the present invention, the ethanol is 70-90% ethanol.
同时,本发明还提供了所述贴剂的制备方法,包括:Meanwhile, the present invention also provides a preparation method of the patch, comprising:
步骤1、黎药蜘蛛乙醇浸泡,获得醇提液;泽泻、茯苓、五味子、补骨脂、干姜水提醇沉法获得水提液;水提液合并醇提液浓缩成无醇的流浸膏;Step 1. Soak Liyao spider in ethanol to obtain an alcohol extract; Alisma, Poria, Schisandra, Bakuchi, and dried ginger water extraction and alcohol precipitation method to obtain a water extract; the water extract is combined with the alcohol extract and concentrated into an alcohol-free stream extract;
步骤2、所述流浸膏内加入肉桂和麝香,调为稠膏,涂布在贴剂基质上(如巴布膏剂),制成贴剂。Step 2. Add cinnamon and musk into the liquid extract, adjust it into a thick paste, and coat it on a patch base (such as bab ointment) to prepare a patch.
作为优选,所述醇提液由以下制备方法获得:Preferably, the alcohol extract is obtained by the following preparation method:
黎药蜘蛛冻干粉,以70-90%乙醇10-30倍量,常温浸泡24-72小时,操作一次或两次以上,完成后,合并提取液获得醇提液。Liyao spider freeze-dried powder is soaked in 10-30 times the amount of 70-90% ethanol at room temperature for 24-72 hours, and the operation is performed one or more times. After completion, the extracts are combined to obtain an alcohol extract.
作为优选,所述水提液由以下制备方法获得:Preferably, the water extract is obtained by the following preparation method:
泽泻、茯苓、五味子、补骨脂、干姜,加水十倍量,加热煮沸提取一次或两次以上,每次1-3小时,合并药液,浓缩;加入70-90%乙醇,搅拌进行醇沉,获得水提液。Alisma, Poria, Schisandra, Psoralea, dried ginger, add ten times the amount of water, heat and boil to extract one or more times for 1-3 hours each time, combine the medicinal liquids, concentrate; add 70-90% ethanol, stir to carry out Alcohol precipitation to obtain water extract.
为了验证贴剂用于脐下关元的治疗效果,本发明通过减掉五指山蜘蛛、五味子或补骨脂任一药材,发现删减药材后,其临床试验效果明显差于试验组。同时,将组方中的五指山蜘蛛替换为淫羊藿或鹿茸等常用 壮阳药材,可能是由于淫羊藿、鹿茸药材更适用于口服滋补身体,所以制作成对照贴剂的临床效果未出现显著性增强。In order to verify the therapeutic effect of the patch for subumbilical Guanyuan, the present invention reduces any medicinal material of Wuzhishan spider, Schisandra chinensis or Psoralea, and finds that after the medicinal material is deleted, the clinical test effect is significantly worse than that of the test group. At the same time, the Wuzhishan spider in the formula was replaced with commonly used aphrodisiac herbs such as epimedium or velvet antler. It may be because the herbs of epimedium and velvet antler are more suitable for oral nourishment, so the clinical effect of the control patch was not significant. enhanced.
由以上技术方案可知,本发明在对黎药蜘蛛相关的民间验方进行整理提高的基础上,运用现在研究手段,根据中药君臣佐使协同促进的原理,配伍茯苓、麝香等其他中药材,提供一种用于治疗男性勃起障碍、提高男性精子活力和质量的含有黎药蜘蛛的肚脐贴剂,在有效改善男性勃起功能的同时,又能避免长期口服药物,特别是西药而引起的身心严重负担。It can be seen from the above technical solutions that the present invention, on the basis of arranging and improving the folk prescriptions related to Liyao spider, uses current research methods, and according to the principle of synergistic promotion of traditional Chinese medicine, the monarch, ministers, assistants and envoys, is compatible with other Chinese medicinal materials such as tuckahoe and musk, and provides a kind of medicine. The navel patch containing Liyao spider, which is used to treat male erectile dysfunction and improve male sperm motility and quality, can effectively improve male erectile function and at the same time avoid the serious physical and mental burden caused by long-term oral medication, especially western medicine.
本发明公开了一种治疗男性勃起障碍的贴剂及其制备方法,本领域技术人员可以借鉴本文内容,适当改进工艺参数实现。特别需要指出的是,所有类似的替换和改动对本领域技术人员来说是显而易见的,它们都被视为包括在本发明。本发明所述贴剂及其制备方法已经通过较佳实施例进行了描述,相关人员明显能在不脱离本发明内容、精神和范围内对本文所述贴剂及其制备方法进行改动或适当变更与组合,来实现和应用本发明技术。The invention discloses a patch for treating male erectile dysfunction and a preparation method thereof, and those skilled in the art can learn from the content of this article and appropriately improve process parameters to achieve. It should be particularly pointed out that all similar substitutions and modifications are obvious to those skilled in the art, and they are deemed to be included in the present invention. The patch of the present invention and its preparation method have been described through the preferred embodiments, and it is obvious that relevant persons can make changes or appropriate changes to the patch and its preparation method without departing from the content, spirit and scope of the present invention and combinations to implement and apply the technology of the present invention.
肚脐是人体任脉上的神阙阳穴,是人体最关键的要害穴窍和长寿大穴。穴当元魂之门户网,故有回阳救逆、通窍苏厥之作用,调节保健神阙穴,能够调节百脉气血,精神饱满、体力充沛、腰肌强壮、面色红润、耳聪目明、轻身延年。并对腹痛肠鸣、水肿膨胀、泄痢脱肛、中风脱症等有独特的疗效,人体也就健康无病,青春不老。本发明所提供的贴剂用于脐下关元,通过贴剂的药效作用于任脉,达到显著改善男性勃起障碍的效果。The navel is the Shenque Yang point on the Ren meridian of the human body. The acupoint is the gateway of the soul, so it has the functions of returning Yang to save the evil, clearing the orifices and Su Jue, regulating the health care of the Shenque acupoint, which can regulate the qi and blood of the Baimai, full of energy, strong physical strength, strong psoas muscle, ruddy complexion, bright ears and eyesight, light body and prolong life. . It has a unique curative effect on abdominal pain, edema and swelling, dysentery and prolapse of the anus, and stroke and apoplexy. The human body will be healthy and disease-free and youthful. The patch provided by the invention is used for the subumbilical Guanyuan, and the medicinal effect of the patch acts on the Ren vessel, thereby achieving the effect of significantly improving male erectile dysfunction.
在本发明具体实施方式中,所提供的对比试验各处理组所采用的原料药均相同,且各组除去应有的区别外其他试验条件保持一致。In the specific embodiment of the present invention, the raw materials used in each treatment group of the provided comparative test are the same, and the other test conditions are the same in each group except for due differences.
本发明所涉及原料药、试剂等,如无特殊说明均可通过市售途径获得。The raw materials, reagents, etc. involved in the present invention can be obtained through commercial channels unless otherwise specified.
下面结合实施例,进一步阐述本发明。Below in conjunction with embodiment, the present invention is further elaborated.
实施例1:制备本发明所述贴剂Example 1: Preparation of the patch of the present invention
1、配方1. Recipe
五指山蜘蛛冻干粉5份(5g)、泽泻20份(20g)、茯苓25份(25g)、五味子20份(20g)、补骨脂30份(30g)、肉桂5份(5g)、干姜2份(2g)、麝香(人工)1份(1g);Wuzhishan spider freeze-dried powder 5 parts (5g), Alisma 20 parts (20g), Poria 25 parts (25g), Schisandra 20 parts (20g), psoralen 30 parts (30g), cinnamon 5 parts (5g), dried 2 parts (2g) of ginger, 1 part (1g) of musk (artificial);
2、制法2. Method of making
①蜘蛛冻干粉,以80%乙醇20倍量,常温浸泡48小时,共操作两次,完成后,合并提取液。①The spider freeze-dried powder was soaked in 20 times the amount of 80% ethanol at room temperature for 48 hours, and the operation was performed twice. After completion, the extracts were combined.
②其他药材(麝香、肉桂除外),水提取,加水十倍量,加热煮沸提取两次,每次1.5小时,合并药液,浓缩至相对密度1.2;加入70%乙醇,一边搅拌、徐徐加入,搅拌30分钟。醇沉罐夹套冷却水降温冷却,静置48小时;取上清液合并蜘蛛提取液,浓缩至无醇。相对密度1.12,得到约100ml液体。②Other medicinal materials (except musk and cinnamon), extract with water, add ten times the amount of water, heat and boil for extraction twice, each time for 1.5 hours, combine the medicinal liquids, and concentrate to a relative density of 1.2; add 70% ethanol, stir and add slowly, Stir for 30 minutes. The alcohol precipitation tank jacket was cooled with cooling water, and allowed to stand for 48 hours; the supernatant was combined with the spider extract, and concentrated to no alcohol. The relative density is 1.12, resulting in about 100 ml of liquid.
③肉桂粉碎为极细粉(《中国药典》(2015版)规定,能全部通过六号筛,并含能通过七号筛不少于95%的粉末),并麝香加入流浸膏内,调为稠膏。3. Cinnamon is crushed into very fine powder (the "Chinese Pharmacopoeia" (2015 edition) stipulates that it can all pass through the No. 6 sieve, and contains no less than 95% of the powder that can pass the No. 7 sieve), and musk is added into the liquid extract to adjust. For thick paste.
④将稠膏添加适量基质,涂布为贴剂。贴于肚脐下(关元),每日一贴。④Add an appropriate amount of base to the thick paste and apply it as a patch. Paste it under the navel (Guanyuan), once a day.
实施例2:治疗效果实验Example 2: Therapeutic effect experiment
经海南省某中医院制备院内制剂,在其黎族医药专业诊室进行临床试验。选择年龄在40-60岁,200名的男性临床试用者,分7组,除对照组(未进行任何处理治疗)为20名外其余每组30名患者,进行了为期90天的临床试验,根据《临床疾病诊断依据治愈好转标准》治愈好转标准,治愈标准:阴茎可勃起及进行性交。好转标准:阴茎可短暂勃起,但不能完成性交。无效:阴茎无法勃起且无法性交。具体试验结果如表1。In-hospital preparations were prepared by a Chinese medicine hospital in Hainan Province, and clinical trials were carried out in its Li nationality medicine professional clinic. 200 male clinical trial subjects aged 40-60 years were selected and divided into 7 groups. Except for the control group (without any treatment), which consisted of 20 patients, the remaining 30 patients in each group conducted a 90-day clinical trial. According to the "Clinical Disease Diagnosis Based on Cure and Improvement Criteria", the cure and improvement criteria are as follows: the penis can be erected and sexual intercourse can be performed. Improvement criteria: the penis can be erected briefly, but intercourse cannot be completed. Ineffective: The penis cannot be erected and intercourse cannot be performed. The specific test results are shown in Table 1.
表1Table 1
根据表1可以看出,本发明的肚脐贴剂对治疗男性勃起障碍有效率可以达到90%,疗效效果显著,且未发现不良反应。通过减掉蜘蛛、五味子或补骨脂任一药材,发现删减药材后,其临床试验效果(对比组1、对比组2、对比组3)明显差于试验组。同时,用淫羊藿、鹿茸等常用壮阳药材替换掉五指山蜘蛛,可能是由于淫羊藿、鹿茸药材更适用于口服滋补身体,所以制作成贴剂,其临床效果(对比组4、对比组5)亦明显差于试验组。As can be seen from Table 1, the effective rate of the navel patch of the present invention can reach 90% for the treatment of male erectile dysfunction, the curative effect is remarkable, and no adverse reaction is found. By subtracting any medicinal material of spider, schisandra or psoralea, it was found that after the medicinal material was deleted, the clinical test effect (comparison group 1, comparison group 2, and comparison group 3) was significantly worse than that of the experimental group. At the same time, the commonly used aphrodisiac herbs such as epimedium and deer antler were used to replace Wuzhishan spider, probably because the herbs of epimedium and deer antler are more suitable for oral nourishment, so they were made into patches. ) was also significantly worse than the experimental group.
以上所述仅是本发明的优选实施方式,应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。The above are only the preferred embodiments of the present invention. It should be pointed out that for those skilled in the art, without departing from the principles of the present invention, several improvements and modifications can be made. It should be regarded as the protection scope of the present invention.
Claims (7)
- 一种治疗男性勃起障碍的贴剂,其特征在于,活性药物由黎药蜘蛛醇提物和泽泻、茯苓、五味子、补骨脂、干姜五味药的水提物,以及肉桂和麝香组成。A patch for the treatment of male erectile dysfunction is characterized in that the active medicine is composed of the alcohol extract of Liyao spider and the water extract of Alisma, Poria, Schisandra, Psoralea, dried ginger, and cinnamon and musk.
- 根据权利要求1所述贴剂,其特征在于,各原料药的重量份数为黎药蜘蛛4-6份、泽泻15-25份、茯苓20-30份、五味子15-25份、补骨脂25-35份、肉桂3-7份、干姜1-3份和麝香0.5-1.5份。The patch according to claim 1, wherein the parts by weight of each crude drug are 4-6 parts of Liyao spider, 15-25 parts of Alisma, 20-30 parts of Poria, 15-25 parts of Schisandra chinensis, Bone 25-35 parts of fat, 3-7 parts of cinnamon, 1-3 parts of dried ginger and 0.5-1.5 parts of musk.
- 根据权利要求1所述贴剂,其特征在于,所述黎药蜘蛛醇提物为其乙醇浸泡后的提取液。The patch according to claim 1, characterized in that, the alcohol extract of Liyao spider is the extract after being soaked in ethanol.
- 根据权利要求1-3任意一项所述贴剂,其特征在于,所述黎药蜘蛛为五指山蜘蛛。The patch according to any one of claims 1-3, characterized in that, the spider is Wuzhishan spider.
- 权利要求1所述贴剂的制备方法,其特征在于,包括:The preparation method of the described patch of claim 1, is characterized in that, comprises:步骤1、黎药蜘蛛乙醇浸泡,获得醇提液;泽泻、茯苓、五味子、补骨脂、干姜水提醇沉法获得水提液;水提液合并醇提液浓缩成无醇的流浸膏;Step 1. Soak Liyao spider in ethanol to obtain an alcohol extract; Alisma, Poria, Schisandra, Bakuchi, and dried ginger water extraction and alcohol precipitation method to obtain a water extract; the water extract is combined with the alcohol extract and concentrated into an alcohol-free stream extract;步骤2、所述流浸膏内加入肉桂和麝香,调为稠膏,涂布在贴剂基质上,获得贴剂。Step 2. Add cinnamon and musk into the liquid extract, adjust it into a thick paste, and coat it on the patch base to obtain a patch.
- 根据权利要求5所述制备方法,其特征在于,所述醇提液由以下制备方法获得:The preparation method according to claim 5, wherein the alcohol extract is obtained by the following preparation method:黎药蜘蛛冻干粉,以70-90%乙醇10-30倍量,常温浸泡24-72小时,操作一次或两次以上,完成后,合并提取液获得醇提液。Liyao spider freeze-dried powder is soaked in 10-30 times the amount of 70-90% ethanol at room temperature for 24-72 hours, and the operation is performed one or more times. After completion, the extracts are combined to obtain an alcohol extract.
- 根据权利要求5所述制备方法,其特征在于,所述水提液由以下制备方法获得:The preparation method according to claim 5, wherein the water extract is obtained by the following preparation method:泽泻、茯苓、五味子、补骨脂、干姜,加水十倍量,加热煮沸提取一次或两次以上,每次1-3小时,合并药液,浓缩;加入70-90%乙醇,搅拌进行醇沉,获得水提液。Alisma, Poria, Schisandra, Psoralea, dried ginger, add ten times the amount of water, heat and boil to extract one or more times for 1-3 hours each time, combine the medicinal liquids, concentrate; add 70-90% ethanol, stir to carry out Alcohol precipitation to obtain water extract.
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---|---|---|---|---|
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Non-Patent Citations (4)
Title |
---|
KANG YAGUO: "Insect Medicinals Elucidation", LIAONING JOURNAL OF TRADITIONAL CHINESE MEDICINE, vol. 33, no. 8, 18 August 2006 (2006-08-18), pages 1008 - 1009, XP055949323, ISSN: 1000-1719, DOI: 10.13192/j.ljtcm.2006.08.100.kangyg.071 * |
LIU BINGREN: "Clinical Medicinal Recipes for Spiders", JOURNAL OF ECONOMIC ANIMAL, vol. 4, no. 4, 30 December 2000 (2000-12-30), pages 17 - 17, XP055949332, DOI: 10.13326/j.jea.2000.04.008 * |
TANG, ET AL.: "Analysis of the Medication Characteristics on Male Infertility in Ancient Based on Literature Data", JOURNAL OF HUNAN UNIVERSITY OF CHINESE MEDICINE, HUNAN UNIVERSITY OF CHINESE MEDICINE, CN, vol. 37, no. 2, 25 February 2017 (2017-02-25), CN, pages 225 - 228, XP055949328, ISSN: 1674-070X, DOI: 10.3969/j.issn.1674-070X.2017.02.029 * |
TIAN JANPING, ET AL. : "History and Application Characteristics of Domestic Spider Used for Medicine and Edible Resources", CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE, ZHONGGUO ZHONGYI KEXUEYUAN ZHONGYAO YANJIUSUO, CN, vol. 24, no. 3, 28 February 2018 (2018-02-28), CN , pages 214 - 218, XP055949326, ISSN: 1005-9903, DOI: 10.13422/j.cnki.syfjx.2018030214 * |
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