WO2022147925A1 - Patch for treating male erectile dysfunction and preparation method therefor - Google Patents

Abstract

A patch for treating male erectile dysfunction and a preparation method therefor. The patch comprises the following active ingredients: an alcohol extract of Li medicine spider, water extracts of Alismatis rhizoma, Poria, Schisandra chinensis, Fructus psoraleae and Zingiberis rhizoma, and Cinnamomi cortex and Moschus. According to the principle "principal, assistant, complement and mediating guide" in traditional Chinese medicine, the Li medicine spider is combined with other traditional Chinese medicines such as Poria and Moschus, so as to obtain a navel patch for treating male erectile dysfunction and improving male sperm motility and quality. The patch can effectively improve the male erectile function, and can also avoid the serious physical and psychological burden caused by long-term oral administration of medicines, especially western medicines.

Description

A kind of patch for treating male erectile dysfunction and preparation method thereof

This application claims the priority of the Chinese patent application with the application number 202110018542.1 and the invention titled "A patch for treating male erectile dysfunction and its preparation method", which was submitted to the China Patent Office on January 7, 2021, the entire contents of which are approved by Reference is incorporated in this application.

technical field

The invention relates to the technical field of traditional Chinese medicines, and more particularly to a patch for treating erectile dysfunction in men and a preparation method thereof.

Background technique

With the continuous acceleration of the pace of life, air pollution, bad living habits, genetics and other factors, the male body in my country is prone to excessive fatigue, which leads to increasingly serious sexual dysfunction and an increasing number of people. Male sexual dysfunction is mainly manifested as impotence and premature ejaculation, accompanied by low sperm and insufficient vitality, which lead to infertility and infertility, which seriously affect the quality of life. Traditional medicines for male dysfunction are mainly western medicines, which are quick to take effect, but have many side effects or adverse reactions. Long-term use will cause a greater burden on health.

Li Yao spider has the effect of invigorating qi and blood, adding essence and strengthening yang. It is mainly used to treat the symptoms of weak fire in the door of life, deficiency of kidney yang, impotence, impotence, cold in the lower yuan, cold essence and childlessness. The local people of the Li nationality in Hainan often roast spiders or make wine with spiders to keep fit and resist dampness. Although the habit of Li medicine spiders has been passed down for thousands of years, the Li people have no written language, and the inheritance mainly relies on word of mouth.

SUMMARY OF THE INVENTION

In view of this, the purpose of the present invention is to provide a patch for treating male erectile dysfunction and a preparation method thereof, so that the patch can be used in the lower navel of human body and can significantly improve male erectile dysfunction.

To achieve the above-mentioned purpose of the invention, the present invention provides the following technical solutions:

A patch for the treatment of male erectile dysfunction, the active drug of which is composed of the alcohol extract of Liyao spider and the water extract of Alisma, Poria, Schisandra, Bakuchi, dried ginger, and cinnamon and musk (artificial).

The selected Liyao spider in the present invention is the Wuzhishan spider, which is a unique national geographical indication agricultural product in Wuzhishan, Hainan. As a totem of the ancestors of the Li nationality and a folk heritage recipe, the Wuzhishan spider is famous for its plumpness and delicious taste. It is crispy and delicious after baking and has a long aftertaste. The Li people in Hainan have a history of eating fried spiders, grilling spiders or making wine with spiders for thousands of years to nourish yin and strengthen yang and strengthen their bodies. Li nationality doctors use roasted spiders to reduce fire and drive away cold, strengthen yang and invigorate the kidneys, treat deficiency, and have a high social awareness. Modern research methods have found that Wuzhishan spiders are high in protein and rich in essential trace elements such as calcium, manganese, zinc, iron, etc., which are not only nutritious and delicious, but also have significant health care and therapeutic effects.

At the same time, it is also a local and authentic medicinal material, which dispels dampness, reduces inflammation and detoxifies, and nourishes kidney yang. It can be used as medicine to treat various diseases such as rheumatism, bone pain, stroke, and oblique mouth. There are records. Since ancient times, the Li people of Hainan have used roasted spiders or spider wine to expel wind and dehumidify to strengthen their body; local Li doctors in Wuzhishan also use spiders as their king medicine to treat gout, rheumatism, joint swelling and pain, neck and waist pain and other diseases , the curative effect has been highly recognized by local patients; but there is no relevant record for its use in the navel Xiaguanyuan patch.

The present invention uses Wuzhishan spider to cooperate with other traditional Chinese medicine components to jointly treat male erectile dysfunction:

Alisma, enter the kidney, spleen, diuretic water and dampness, long-term smart ears and eyes, prolong youth, used for the treatment of inner ear vertigo, dyslipidemia, nocturnal emission, fatty liver and diabetes, etc. "Benjing": "maintains wind, cold and dampness, reduces thirst, nourishes the five internal organs, and replenishes qi." "Bielu": "Tonic for deficiency and loss of five labors, in addition to fullness of the five internal organs, invigorating yin qi, stopping semen ejaculation, quenching thirst, and stranguria Lek, remove bladder and Sanjiao and stop water."

Poria cocos, the dried sclerotia of Poria cocos (Schw.) Wolf, a fungus of Poriaaceae Efficacy, commonly used as an adjuvant for strengthening the spleen and tonifying qi deficiency.

Schisandra chinensis, the dried and ripe fruit of Schisandra chinensis (Turcz.) Baill. of Magnoliaceae .

Psoralea is used in the treatment of impotence due to kidney deficiency, soreness and pain in the waist and knees, nocturnal emission, enuresis, frequent urination, dyspnea and cough due to deficiency.

Cinnamon is suitable for guiding hundreds of medicines, warming the middle and invigorating the kidney, strengthening the muscles and bones, clearing the blood vessels, controlling all diseases, and nourishing the spirit.

Musk, returning to the heart and spleen meridians, opening the orifices and refreshing the mind, promoting blood circulation and clearing the meridians, reducing swelling and relieving pain, mainly treating sore, swollen toxin, scrofula and phlegm nucleus, sore throat, traumatic injury, wind-cold-dampness arthralgia, etc.

Preferably, the parts by weight of each crude drug are 4-6 parts of Liyao spider, 15-25 parts of Alisma, 20-30 parts of Poria, 15-25 parts of Schisandra chinensis, 25-35 parts of psoralen, 3-7 parts of cinnamon servings, 1-3 servings of dried ginger and 0.5-1.5 servings of musk.

In a specific embodiment of the present invention, the parts by weight of each crude drug are 5 parts of Liyao spider, 20 parts of Alisma, 25 parts of Poria, 20 parts of Schisandra, 30 parts of psoralen, 5 parts of cinnamon, 2 parts of dried ginger and 1 part of musk.

Preferably, the alcohol extract of Liyao spider is the extract after soaking in ethanol. In a specific embodiment of the present invention, the ethanol is 70-90% ethanol.

Meanwhile, the present invention also provides a preparation method of the patch, comprising:

Step 1. Soak Liyao spider in ethanol to obtain an alcohol extract; Alisma, Poria, Schisandra, Bakuchi, and dried ginger water extraction and alcohol precipitation method to obtain a water extract; the water extract is combined with the alcohol extract and concentrated into an alcohol-free stream extract;

Step 2. Add cinnamon and musk into the liquid extract, adjust it into a thick paste, and coat it on a patch base (such as bab ointment) to prepare a patch.

Preferably, the alcohol extract is obtained by the following preparation method:

Liyao spider freeze-dried powder is soaked in 10-30 times the amount of 70-90% ethanol at room temperature for 24-72 hours, and the operation is performed one or more times. After completion, the extracts are combined to obtain an alcohol extract.

Preferably, the water extract is obtained by the following preparation method:

Alisma, Poria, Schisandra, Psoralea, dried ginger, add ten times the amount of water, heat and boil to extract one or more times for 1-3 hours each time, combine the medicinal liquids, concentrate; add 70-90% ethanol, stir to carry out Alcohol precipitation to obtain water extract.

In order to verify the therapeutic effect of the patch for subumbilical Guanyuan, the present invention reduces any medicinal material of Wuzhishan spider, Schisandra chinensis or Psoralea, and finds that after the medicinal material is deleted, the clinical test effect is significantly worse than that of the test group. At the same time, the Wuzhishan spider in the formula was replaced with commonly used aphrodisiac herbs such as epimedium or velvet antler. It may be because the herbs of epimedium and velvet antler are more suitable for oral nourishment, so the clinical effect of the control patch was not significant. enhanced.

It can be seen from the above technical solutions that the present invention, on the basis of arranging and improving the folk prescriptions related to Liyao spider, uses current research methods, and according to the principle of synergistic promotion of traditional Chinese medicine, the monarch, ministers, assistants and envoys, is compatible with other Chinese medicinal materials such as tuckahoe and musk, and provides a kind of medicine. The navel patch containing Liyao spider, which is used to treat male erectile dysfunction and improve male sperm motility and quality, can effectively improve male erectile function and at the same time avoid the serious physical and mental burden caused by long-term oral medication, especially western medicine.

Detailed ways

The invention discloses a patch for treating male erectile dysfunction and a preparation method thereof, and those skilled in the art can learn from the content of this article and appropriately improve process parameters to achieve. It should be particularly pointed out that all similar substitutions and modifications are obvious to those skilled in the art, and they are deemed to be included in the present invention. The patch of the present invention and its preparation method have been described through the preferred embodiments, and it is obvious that relevant persons can make changes or appropriate changes to the patch and its preparation method without departing from the content, spirit and scope of the present invention and combinations to implement and apply the technology of the present invention.

The navel is the Shenque Yang point on the Ren meridian of the human body. The acupoint is the gateway of the soul, so it has the functions of returning Yang to save the evil, clearing the orifices and Su Jue, regulating the health care of the Shenque acupoint, which can regulate the qi and blood of the Baimai, full of energy, strong physical strength, strong psoas muscle, ruddy complexion, bright ears and eyesight, light body and prolong life. . It has a unique curative effect on abdominal pain, edema and swelling, dysentery and prolapse of the anus, and stroke and apoplexy. The human body will be healthy and disease-free and youthful. The patch provided by the invention is used for the subumbilical Guanyuan, and the medicinal effect of the patch acts on the Ren vessel, thereby achieving the effect of significantly improving male erectile dysfunction.

In the specific embodiment of the present invention, the raw materials used in each treatment group of the provided comparative test are the same, and the other test conditions are the same in each group except for due differences.

The raw materials, reagents, etc. involved in the present invention can be obtained through commercial channels unless otherwise specified.

Below in conjunction with embodiment, the present invention is further elaborated.

Example 1: Preparation of the patch of the present invention

1. Recipe

Wuzhishan spider freeze-dried powder 5 parts (5g), Alisma 20 parts (20g), Poria 25 parts (25g), Schisandra 20 parts (20g), psoralen 30 parts (30g), cinnamon 5 parts (5g), dried 2 parts (2g) of ginger, 1 part (1g) of musk (artificial);

2. Method of making

①The spider freeze-dried powder was soaked in 20 times the amount of 80% ethanol at room temperature for 48 hours, and the operation was performed twice. After completion, the extracts were combined.

②Other medicinal materials (except musk and cinnamon), extract with water, add ten times the amount of water, heat and boil for extraction twice, each time for 1.5 hours, combine the medicinal liquids, and concentrate to a relative density of 1.2; add 70% ethanol, stir and add slowly, Stir for 30 minutes. The alcohol precipitation tank jacket was cooled with cooling water, and allowed to stand for 48 hours; the supernatant was combined with the spider extract, and concentrated to no alcohol. The relative density is 1.12, resulting in about 100 ml of liquid.

3. Cinnamon is crushed into very fine powder (the "Chinese Pharmacopoeia" (2015 edition) stipulates that it can all pass through the No. 6 sieve, and contains no less than 95% of the powder that can pass the No. 7 sieve), and musk is added into the liquid extract to adjust. For thick paste.

④Add an appropriate amount of base to the thick paste and apply it as a patch. Paste it under the navel (Guanyuan), once a day.

Example 2: Therapeutic effect experiment

In-hospital preparations were prepared by a Chinese medicine hospital in Hainan Province, and clinical trials were carried out in its Li nationality medicine professional clinic. 200 male clinical trial subjects aged 40-60 years were selected and divided into 7 groups. Except for the control group (without any treatment), which consisted of 20 patients, the remaining 30 patients in each group conducted a 90-day clinical trial. According to the "Clinical Disease Diagnosis Based on Cure and Improvement Criteria", the cure and improvement criteria are as follows: the penis can be erected and sexual intercourse can be performed. Improvement criteria: the penis can be erected briefly, but intercourse cannot be completed. Ineffective: The penis cannot be erected and intercourse cannot be performed. The specific test results are shown in Table 1.

Table 1

As can be seen from Table 1, the effective rate of the navel patch of the present invention can reach 90% for the treatment of male erectile dysfunction, the curative effect is remarkable, and no adverse reaction is found. By subtracting any medicinal material of spider, schisandra or psoralea, it was found that after the medicinal material was deleted, the clinical test effect (comparison group 1, comparison group 2, and comparison group 3) was significantly worse than that of the experimental group. At the same time, the commonly used aphrodisiac herbs such as epimedium and deer antler were used to replace Wuzhishan spider, probably because the herbs of epimedium and deer antler are more suitable for oral nourishment, so they were made into patches. ) was also significantly worse than the experimental group.

The above are only the preferred embodiments of the present invention. It should be pointed out that for those skilled in the art, without departing from the principles of the present invention, several improvements and modifications can be made. It should be regarded as the protection scope of the present invention.

Claims (7)

1. A patch for the treatment of male erectile dysfunction is characterized in that the active medicine is composed of the alcohol extract of Liyao spider and the water extract of Alisma, Poria, Schisandra, Psoralea, dried ginger, and cinnamon and musk.
2. The patch according to claim 1, wherein the parts by weight of each crude drug are 4-6 parts of Liyao spider, 15-25 parts of Alisma, 20-30 parts of Poria, 15-25 parts of Schisandra chinensis, Bone 25-35 parts of fat, 3-7 parts of cinnamon, 1-3 parts of dried ginger and 0.5-1.5 parts of musk.
3. The patch according to claim 1, characterized in that, the alcohol extract of Liyao spider is the extract after being soaked in ethanol.
4. The patch according to any one of claims 1-3, characterized in that, the spider is Wuzhishan spider.
5. The preparation method of the described patch of claim 1, is characterized in that, comprises:

   Step 1. Soak Liyao spider in ethanol to obtain an alcohol extract; Alisma, Poria, Schisandra, Bakuchi, and dried ginger water extraction and alcohol precipitation method to obtain a water extract; the water extract is combined with the alcohol extract and concentrated into an alcohol-free stream extract;

   Step 2. Add cinnamon and musk into the liquid extract, adjust it into a thick paste, and coat it on the patch base to obtain a patch.
6. The preparation method according to claim 5, wherein the alcohol extract is obtained by the following preparation method:

   Liyao spider freeze-dried powder is soaked in 10-30 times the amount of 70-90% ethanol at room temperature for 24-72 hours, and the operation is performed one or more times. After completion, the extracts are combined to obtain an alcohol extract.
7. The preparation method according to claim 5, wherein the water extract is obtained by the following preparation method:

   Alisma, Poria, Schisandra, Psoralea, dried ginger, add ten times the amount of water, heat and boil to extract one or more times for 1-3 hours each time, combine the medicinal liquids, concentrate; add 70-90% ethanol, stir to carry out Alcohol precipitation to obtain water extract.