CN1903244A - Traditional Chinese medicine composition for treating sexual disorders - Google Patents
Traditional Chinese medicine composition for treating sexual disorders Download PDFInfo
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- CN1903244A CN1903244A CNA2006101092805A CN200610109280A CN1903244A CN 1903244 A CN1903244 A CN 1903244A CN A2006101092805 A CNA2006101092805 A CN A2006101092805A CN 200610109280 A CN200610109280 A CN 200610109280A CN 1903244 A CN1903244 A CN 1903244A
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Abstract
A Chinese medicine for treating sexual disfunction, such as impotence, prospermia and ED, is prepared from musk, cnidium fruit and epimedium.
Description
Technical field
The invention belongs to the pharmaceutical technology field, be specifically related to the Chinese medicine composition that a kind of therapeutic dysfunction especially refers to male erectile dysfunction, it is characterized in that said composition basis prescription is Moschus, Fructus Cnidii and Herba Epimedii.
Background technology
Moschus
Moschus is Moschus again, two kinds of existing artificial Moschus and natural Moschuss, and the natural Moschus has the trend that is replaced by the artificial Moschus.
Moschus chemical constituent: cholesterol 2.19%, crude fibre 0.59%, fatty acid 5.15%, muscone (Mus-cone) 1.2%.The main fragrance ingredient of Moschus is a muscone, but contains a spot of normuscone (Normuscone).Other contains deer perfume pyridine (muscopyridine); Steroidal compounds has cholesterol etc.
Moschus is had one's ideas straightened out, ward off dirty, collateral dredging, dissipating blood stasis cures mainly apoplexy, syncope due to accumulation of phlegm, infantile convulsion, attacked by pestiferous factors unhappiness, trusted subordinate's sudden pain, the lump in the abdomen hypochondriac lump, traumatic injury, swollen ulcer drug.Join Borneolum Syntheticum: the refreshment of having one's ideas straightened out; Join Olibanum: the promoting blood circulation and detumescence pain relieving; Join Cortex Cinnamomi: the tire of hastening parturition down.
Fructus Cnidii
Fructus Cnidii is the fruit of dicotyledon medicine samphire cnidium monnieri, has warming the kidney to activate YANG, dispels the wind, and the effect of removing dampness and killing parasites cures mainly: impotence in male, and the scrotum pruritus due to damp pathogen, woman's leukorrhagia pudendal pruritus, cold uterus is infertile, rheumatism, scabies eczema.
The Fructus Cnidii chemical constituent: fruit contains volatile oil 1.3%, contain osthole (osthole) again, cnidimine etc., its effective ingredient is a Fructus Cnidii total coumarins, wherein the monomer osthole accounts for 60% of TCCM, has effects such as blood vessel dilating, gonadotropic Effect and raising immunologic function.
Herba Epimedii
Herba Epimedii is the stem and leaf of dicotyledon medicine Berberidaceae plant Herba Epimedii, lobus cardiacus Herba Epimedii or arrow leaf Herba Epimedii.Effect: kidney invigorating and YANG supporting, expelling wind and removing dampness cures mainly: the sexual impotence erectile problem, dribbling urination, the muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatism carbuncle pain, extremity are meciless.
The Herba Epimedii medicinal history is long, derives from the various plants of Berberidaceae Epimedium.Li Shizhen (1518-1593 A.D.) claims it that effect of " beneficial vital essence, hard muscles and bones are mended the waist knee joint, heart tonifying power " is arranged in Compendium of Material Medica.The modern pharmacology experimentation shows that Herba Epimedii can increase the cardiovascular and cerebrovascular vessel blood flow, the function of hypophysis-gonad system is had facilitation promote hemopoietic function, immunologic function and bone metabolism, has effects such as defying age, antitumor.Icariin has direct stimulation to follicular cell secretion estradiol, also promotes adrenal cortical cell secretion corticosterone.The reinforcing the kidney and supporting YANG anti-aging effects of prompting Herba Epimedii directly stimulates the target gland secreting hormone relevant with it.
Do not find Moschus, Fructus Cnidii and the use of Herba Epimedii three compatibility aspect the therapeutic dysfunction through literature search.
Summary of the invention
The present invention disclose first Moschus, Fructus Cnidii and Herba Epimedii three as basis side's compatibility in the application aspect the therapeutic dysfunction, confirm to have the effect that the treatment impotence and premature ejaculation is especially improved male erectile dysfunction through animal experiment and human trial.
The basis side of said composition is made up of the medical material of following weight parts
Moschus 0.01-10
Fructus Cnidii 1-100
Herba Epimedii 1-100
Compositions more preferably parts by weight is:
Moschus 0.05-5
Fructus Cnidii 1-30
Herba Epimedii 1-30
Compositions more preferably parts by weight is
Moschus 0.05-1
Fructus Cnidii 3-20
Herba Epimedii 3-20
The application of Chinese medicine composition of the present invention in the therapeutic dysfunction, the especially application aspect male erectile dysfunction can also the compatibility diaphoretic medicine, in awaking drug and the Yang-strengthening drug one or more to be to heighten the effect of a treatment.Wherein diaphoretic medicine specifically refers to the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii; Qi-tonifying drug specifically refers to Rhizoma Dioscoreae, Radix Panacis Quinquefolii and Herb Gynostemmae Pentaphylli; Yang-strengthening drug specifically refers to Cornu Cervi Pantotrichum, Radix Morindae Officinalis, meat desert appearance, Rhizoma Curculiginis, Fructus Psoraleae, Gecko, field dobber, Semen Astragali Complanati, Herba Cynomorii, Semen Allii Tuberosi, Semen Trigonellae, Actinolitum, Cortex Cinnamomi, Rhizoma Alpiniae Officinarum and Radix Kansui, Radix Achyranthis Bidentatae etc.
Survival dose is conventional recommended amounts in each flavor that can compatibility, and Radix Angelicae Dahuricae 3-10g, Rhizoma Et Radix Notopterygii 3-10g, Rhizoma Dioscoreae 3-10g, Radix Panacis Quinquefolii 3-6g, Herb Gynostemmae Pentaphylli 10-20g, Cornu Cervi Pantotrichum 1-3g, Radix Morindae Officinalis 6-15g, meat desert hold 10-15g, Rhizoma Curculiginis 3-10g, Fructus Psoraleae 5-10g, Gecko 3-6g, field dobber 6-15g, Semen Astragali Complanati 10-20g, Herba Cynomorii 6-15g, Semen Allii Tuberosi 5-15g, Semen Trigonellae 3-10g, Actinolitum 3-6g, Cortex Cinnamomi 2-5g, Rhizoma Alpiniae Officinarum 2-5g, Radix Kansui 0.5-1g, Radix Achyranthis Bidentatae 6-15g.
Chinese medicine composition of the present invention can be made the various dosage forms on the medicament book, and its administering mode is oral or topical.
Concrete preparation technology is as follows for Moschus, Fructus Cnidii and Herba Epimedii:
Moschus can directly be used as medicine, and also can pass through supercritical CO
2Extracting its liposoluble constituent is used as medicine.Its preparation method is for putting into Moschus the extraction kettle of supercritical carbon dioxide extraction apparatus, extracting pressure 7-50Mpa, extraction temperature 30-80 ℃.Resolving pressure 1.5-8.0Mpa, collecting under resolution temperature 20-80 ℃, promptly.
Osthole is the main functional component of Fructus Cnidii, its preparation method is: get Fructus Cnidii and add alcohol reflux 2-3 time that 4-12 doubly measures 70-95%, each 1-4 hour, alcohol extract merges, reclaim under reduced pressure is to 2-6 times of the medical material amount, add petroleum ether extraction impurity wherein, recrystallization promptly is able to the Fructus cnidii extract that Fructus Cnidii total coumarins is a main component repeatedly.
General icariin is the main functional component of Herba Epimedii, has the myocardial contraction of improvement, heart pump function, protection cardiac muscle, arrhythmia, anoxia enduring, blood sugar lowering and effect such as antibiotic.Its preparation method is: get Herba Epimedii, adding 10-20 times of water gaging decocts 2-3 time, each 0.5-2 hour, the water extract merges, reclaim under reduced pressure is doubly measured to medical material 0.5-2, adds ethanol and makes and contain the alcohol amount and reach 80%, and cold preservation is spent the night, filter, filtrate decompression is recycled to does not have the alcohol flavor, and extractum adds purified water to medical material 1-4 times, by the macroporous resin column that purifies, elder generation's water flushing, the ethanol elution of reuse 10-30%, at last with the ethanol elution of 40-70% to there not being icariin, collect the ethanol elution of 40-70%, the ethanol elution concentrating under reduced pressure is drying to obtain Herba Epimedii extract.
Prescription 1:
Moschus 0.2g, Fructus Cnidii 10g, Herba Epimedii 10g, Radix Kansui 2g, Radix Angelicae Dahuricae 6g, Fructus Psoraleae 6g, Cortex Cinnamomi 2g
Method for making: the Fructus Cnidii of recipe quantity is made extract according to the method for mentioning among the present invention, Herba Epimedii makes extract according to the method for mentioning among the present invention, the Radix Angelicae Dahuricae, Fructus Psoraleae, Cortex Cinnamomi are used the 50-70% ethanol extraction, concentrate ethanol extract, Moschus directly is used as medicine, and granule is made in the mixing of the extract in the prescription promptly got medicine of the present invention.
Prescription 2:
Moschus 3g, Fructus Cnidii 30g, Herba Epimedii 30g, Radix Panacis Quinquefolii 6g, Radix Morindae Officinalis 5g, Semen Astragali Complanati 10g
Method for making: the Fructus Cnidii of recipe quantity is made extract according to the method for mentioning among the present invention, Herba Epimedii makes extract according to the method for mentioning among the present invention, Radix Morindae Officinalis, Semen Astragali Complanati, Radix Panacis Quinquefolii 50-70% ethanol extraction, concentrate ethanol extract, Moschus directly is used as medicine, granule is made in the mixing of extract in the prescription be divided into three equal parts, promptly get medicine of the present invention.
Prescription 3:
Moschus 0.1g, Rhizoma Et Radix Notopterygii 10g, Fructus Cnidii 6g, Herba Epimedii 12g, Herb Gynostemmae Pentaphylli 12g, Rhizoma Curculiginis 6g
Method for making: the Fructus Cnidii of recipe quantity is made extract according to the method for mentioning among the present invention, Herba Epimedii makes extract according to the method for mentioning among the present invention, Rhizoma Et Radix Notopterygii, Rhizoma Curculiginis and glue thigh basket 50-70% ethanol extraction, concentrate ethanol extract, Moschus directly is used as medicine, and granule is made in the mixing of the extract in the prescription promptly got medicine of the present invention.
Prescription 4:
Moschus 1g, Fructus Cnidii 10g, Herba Epimedii 12g, Actinolitum 3g, Cortex Cinnamomi 6g, Radix Panacis Quinquefolii 6g
Method for making: the Fructus Cnidii of recipe quantity is made extract according to the method for mentioning among the present invention, Herba Epimedii makes extract according to the method for mentioning among the present invention, Radix Panacis Quinquefolii, Actinolitum and Cortex Cinnamomi are used the 50-70% ethanol extraction, concentrate ethanol extract, Moschus directly is used as medicine, and granule is made in the mixing of the extract in the prescription promptly got medicine of the present invention.
Prescription 5:
Moschus 10g, Fructus Cnidii 60g, Herba Epimedii 100g, Radix Panacis Quinquefolii 60g, Herba Cynomorii 20g, field dobber 20g
Method for making: the Fructus Cnidii of recipe quantity is made extract according to the method for mentioning among the present invention, Herba Epimedii makes extract according to the method for mentioning among the present invention, Herba Cynomorii, Radix Panacis Quinquefolii, field dobber 50-70% ethanol extraction, concentrate ethanol extract, Moschus directly is used as medicine, and the extract in the prescription is mixed make granule and be divided into six equal portions and promptly get medicine of the present invention.
Prescription 6:
Moschus 4g, Fructus Cnidii 100g, Herba Epimedii 60g, Radix Panacis Quinquefolii 20g, Gecko 10g, Herba Cynomorii 10g, Semen Trigonellae 10g
Method for making: the Fructus Cnidii of recipe quantity is made extract according to the method for mentioning among the present invention, Herba Epimedii makes extract according to the method for mentioning among the present invention, Radix Panacis Quinquefolii, Herba Cynomorii, Gecko, Semen Trigonellae 50-70% ethanol extraction, concentrate ethanol extract, Moschus directly is used as medicine, and the extract in the prescription is mixed make granule and be divided into 8 equal portions and promptly get medicine of the present invention.
Prescription 7:
Moschus 0.01g, Fructus Cnidii 10g, Herba Epimedii 10g, Fructus Lycii 10g, Cornu Cervi Pantotrichum 3g, Rhizoma Alpiniae Officinarum 3g
Method for making: the Fructus Cnidii of recipe quantity is made extract according to the method for mentioning among the present invention, Herba Epimedii makes extract according to the method for mentioning among the present invention, Fructus Lycii, Cornu Cervi Pantotrichum and Rhizoma Alpiniae Officinarum 50-70% ethanol extraction, concentrate ethanol extract, Moschus directly is used as medicine, and granule is made in the mixing of the extract in the prescription promptly got medicine of the present invention.
Prescription 8
Moschus 0.05g, Fructus Cnidii 15g, Herba Epimedii 15g, Radix Achyranthis Bidentatae 10g, Rhizoma Dioscoreae 6g, Herb Gynostemmae Pentaphylli 12g
Method for making: the Fructus Cnidii of recipe quantity is made extract according to the method for mentioning among the present invention, Herba Epimedii makes extract according to the method for mentioning among the present invention, Radix Achyranthis Bidentatae, Rhizoma Dioscoreae, Herb Gynostemmae Pentaphylli make extract with decoction and alcohol sedimentation technique, concentrate ethanol extract, Moschus directly is used as medicine, and granule is made in the mixing of the extract in the prescription promptly got medicine of the present invention.
Prescription 9:
Moschus 0.01g, Fructus Cnidii 10g, Herba Epimedii 20g, Radix Panacis Quinquefolii 20g
Method for making: the Fructus Cnidii of recipe quantity is made extract according to the method for mentioning among the present invention, and Herba Epimedii, Radix Panacis Quinquefolii make extract according to the method for mentioning among the present invention, and Moschus directly is used as medicine, and granule is made in the mixing of the extract in the prescription promptly got medicine of the present invention.
Pharmacodynamic experiment one:
Get 64 of adult rats, be divided into 8 groups at random, 8 every group, blank group wherein, 8 of positive controls (sildenafil citrate), 8 groups of prescriptions of the present invention, convert computing formula (g of unit) according to the human dosage in the prescription in batches:
Gastric infusion, statistics erection needs time and duration, and the result is as follows:
| Group | Number of animals (only) | Erection need the time (minute) | Duration (minute) |
| The blank group | 8 | Do not have and erect | 0 |
| Positive controls | 8 | 40 | 70 |
| Prescription 1 | 8 | 45 | 30 |
| Prescription 2 | 8 | 30 | 34 |
| Prescription 3 | 8 | 50 | 40 |
| Prescription 4 | 8 | 30 | 40 |
| Prescription 5 | 8 | 45 | 40 |
| Prescription 6 | 8 | 25 | 30 |
Above data show that the present invention's prescription has good therapeutical effect to the rat erection problem.
Pharmacodynamic experiment two:
Get prescription two samples that make, look for 10 of aspiration examination trenchermans, the man, all there is erection problem at the age between 40-45 year.Statistics begins to feel sexual dysfunction and improves the time, the result, having a volunteer to take second day sensualness function erection problem improves, 3 volunteers take the 3rd day sensualness function erection problem and improve, 3 volunteers take the 5th day sensualness function erection problem and improve, 2 volunteers take the 7th day sensualness function erection problem and improve, and a people is invalid, and total effective rate is 90%.
The result shows that the present invention improves significantly to the male erectile disorder tool.
Claims (8)
1, a kind of Chinese medicine composition by Moschus, Fructus Cnidii, Herba Epimedii compatibility is characterized in that the basis side of said composition is made up of the medical material of following weight parts
Moschus 0.01-10
Fructus Cnidii 1-100
Herba Epimedii 1-100.
2,, it is characterized in that the parts by weight of said composition are according to the described Chinese medicine composition of claim 1:
Moschus 0.05-5
Fructus Cnidii 1-30
Herba Epimedii 1-30.
3,, it is characterized in that the parts by weight of said composition are according to the described Chinese medicine composition of claim 2:
Moschus 0.05-1
Fructus Cnidii 3-20
Herba Epimedii 3-20.
4, according to the described Chinese medicine composition of claim 1, it is characterized in that can also the compatibility diaphoretic medicine, in Qi-tonifying drug and the Yang-strengthening drug one or more to be to heighten the effect of a treatment.
5, according to the application of Chinese medicine composition in the therapeutic dysfunction of any one qualification among the claim 1-4, mainly refer to impotence and premature ejaculation, especially the application in male erectile disorder.
6, according to the described Chinese medicine composition of claim 4, wherein diaphoretic medicine specifically refers to the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii; Qi-tonifying drug specifically refers to Rhizoma Dioscoreae, Radix Panacis Quinquefolii and Herb Gynostemmae Pentaphylli; Yang-strengthening drug specifically refers to Cornu Cervi Pantotrichum, Radix Morindae Officinalis, meat desert appearance, Rhizoma Curculiginis, Fructus Psoraleae, Gecko, field dobber, Semen Astragali Complanati, Herba Cynomorii, Semen Allii Tuberosi, Semen Trigonellae, Actinolitum, Cortex Cinnamomi, Rhizoma Alpiniae Officinarum and Radix Kansui, Radix Achyranthis Bidentatae etc.
7, according to the described Chinese medicine composition of claim 6, survival dose is conventional recommended amounts in each flavor that wherein can compatibility, and Radix Angelicae Dahuricae 3-10g, Rhizoma Et Radix Notopterygii 3-10g, Rhizoma Dioscoreae 3-10g, Radix Panacis Quinquefolii 3-6g, Herb Gynostemmae Pentaphylli 10-20g, Cornu Cervi Pantotrichum 1-3g, Radix Morindae Officinalis 6-15g, meat desert hold 10-15g, Rhizoma Curculiginis 3-10g, Fructus Psoraleae 5-10g, Gecko 3-6g, field dobber 6-15g, Semen Astragali Complanati 10-20g, Herba Cynomorii 6-15g, Semen Allii Tuberosi 5-15g, Semen Trigonellae 3-10g, Actinolitum 3-6g, Cortex Cinnamomi 2-5g, Rhizoma Alpiniae Officinarum 2-5g, Radix Kansui 0.5-2g, Radix Achyranthis Bidentatae 6-15g.
8, according to the described Chinese medicine composition of claim 1-4, can make the various dosage forms on the medicament book, its administering mode is oral or topical.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101092805A CN1903244A (en) | 2006-08-08 | 2006-08-08 | Traditional Chinese medicine composition for treating sexual disorders |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101092805A CN1903244A (en) | 2006-08-08 | 2006-08-08 | Traditional Chinese medicine composition for treating sexual disorders |
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| CN1903244A true CN1903244A (en) | 2007-01-31 |
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| CNA2006101092805A Pending CN1903244A (en) | 2006-08-08 | 2006-08-08 | Traditional Chinese medicine composition for treating sexual disorders |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885870A (en) * | 2012-10-26 | 2013-01-23 | 李为彬 | Medicament for treating male impotence |
| CN103070999A (en) * | 2013-01-22 | 2013-05-01 | 青岛市市立医院 | Medicine composition for treating premature ejaculation and preparation method of same |
| CN112603987A (en) * | 2021-01-07 | 2021-04-06 | 海南蛛王生物科技有限公司 | Patch for treating male erectile dysfunction and preparation method thereof |
-
2006
- 2006-08-08 CN CNA2006101092805A patent/CN1903244A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885870A (en) * | 2012-10-26 | 2013-01-23 | 李为彬 | Medicament for treating male impotence |
| CN103070999A (en) * | 2013-01-22 | 2013-05-01 | 青岛市市立医院 | Medicine composition for treating premature ejaculation and preparation method of same |
| CN103070999B (en) * | 2013-01-22 | 2015-03-18 | 青岛市市立医院 | Medicine composition for treating premature ejaculation and preparation method of same |
| CN112603987A (en) * | 2021-01-07 | 2021-04-06 | 海南蛛王生物科技有限公司 | Patch for treating male erectile dysfunction and preparation method thereof |
| CN112603987B (en) * | 2021-01-07 | 2022-12-02 | 海南蛛王生物科技有限公司 | Patch for treating male erectile dysfunction and preparation method thereof |
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Application publication date: 20070131 |