WO2022133247A3 - Composition et procédé de conservation de la viabilité d'une cellule dans un environnement à basse température - Google Patents

Composition et procédé de conservation de la viabilité d'une cellule dans un environnement à basse température Download PDF

Info

Publication number
WO2022133247A3
WO2022133247A3 PCT/US2021/064086 US2021064086W WO2022133247A3 WO 2022133247 A3 WO2022133247 A3 WO 2022133247A3 US 2021064086 W US2021064086 W US 2021064086W WO 2022133247 A3 WO2022133247 A3 WO 2022133247A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
composition
low temperature
temperature environment
preserving viability
Prior art date
Application number
PCT/US2021/064086
Other languages
English (en)
Other versions
WO2022133247A2 (fr
Inventor
Jingxing OU
Guanghui JIN
Yang Yang
Wei Liu
Lihao GE
Kiyoharu Joshua MIYAGISHIMA
Wei Li
Original Assignee
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Third Affiliated Hospital Of Sun Yat-Sen University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Third Affiliated Hospital Of Sun Yat-Sen University filed Critical The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Priority to CA3202729A priority Critical patent/CA3202729A1/fr
Priority to EP21844141.8A priority patent/EP4262384A2/fr
Priority to AU2021400321A priority patent/AU2021400321A1/en
Priority to US18/258,125 priority patent/US20240041023A1/en
Publication of WO2022133247A2 publication Critical patent/WO2022133247A2/fr
Publication of WO2022133247A3 publication Critical patent/WO2022133247A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne une composition pour traiter une cellule, un tissu ou un organe pour résister à l'exposition et/ou préserver la viabilité lors d'une exposition à un environnement à basse température, et des procédés d'utilisation de telles compositions. La cellule, le tissu ou l'organe est de préférence une cornée ou une cellule cornéenne.
PCT/US2021/064086 2020-12-17 2021-12-17 Composition et procédé de conservation de la viabilité d'une cellule dans un environnement à basse température WO2022133247A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA3202729A CA3202729A1 (fr) 2020-12-17 2021-12-17 Composition et procede de conservation de la viabilite d'une cellule dans un environnement a basse temperature
EP21844141.8A EP4262384A2 (fr) 2020-12-17 2021-12-17 Composition et procédé de conservation de la viabilité d'une cellule dans un environnement à basse température
AU2021400321A AU2021400321A1 (en) 2020-12-17 2021-12-17 Composition and method of preserving viability of cell in a low temperature environment
US18/258,125 US20240041023A1 (en) 2020-12-17 2021-12-17 Composition and method of preserving viability of cell in a low temperature

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202011500962.5A CN112602703B (zh) 2020-12-17 2020-12-17 一种细胞、组织或器官冷保存液的制备方法与应用
CN202011500962.5 2020-12-17

Publications (2)

Publication Number Publication Date
WO2022133247A2 WO2022133247A2 (fr) 2022-06-23
WO2022133247A3 true WO2022133247A3 (fr) 2022-08-18

Family

ID=75240975

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/064086 WO2022133247A2 (fr) 2020-12-17 2021-12-17 Composition et procédé de conservation de la viabilité d'une cellule dans un environnement à basse température

Country Status (6)

Country Link
US (1) US20240041023A1 (fr)
EP (1) EP4262384A2 (fr)
CN (1) CN112602703B (fr)
AU (1) AU2021400321A1 (fr)
CA (1) CA3202729A1 (fr)
WO (1) WO2022133247A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240215569A1 (en) * 2021-07-27 2024-07-04 Gateway Genomics, Llc Methods, compositions, and kits for the preservation of nucleic acids

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153582A (en) * 1998-11-05 2000-11-28 Bausch & Lomb Surgical, Inc. Defined serumfree medical solution for ophthalmology
CN102578078A (zh) * 2012-02-02 2012-07-18 温州医学院附属第二医院 一种神经细胞的冻存液及冻存方法
CN103190392A (zh) * 2013-03-28 2013-07-10 北京大学第三医院 一种角膜中期保存液及其制备方法
WO2014010685A1 (fr) * 2012-07-11 2014-01-16 石原産業株式会社 Conservateur pour l'utilisation dans la conservation à basse température de matière biologique, et procédé de conservation de matière biologique à basse température
CN109423473A (zh) * 2017-08-21 2019-03-05 青岛瑞思德生物科技有限公司 用于制备胎盘干细胞的试剂盒
CN111727961A (zh) * 2020-08-10 2020-10-02 医微细胞生物技术(广州)有限公司 一种牙髓干细胞冻存液及其冻存方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104170815B (zh) * 2013-05-22 2016-06-29 烟台正海生物科技股份有限公司 一种辐照灭菌前对生物材料进行保护的方法
CN112105366B (zh) 2017-08-21 2024-04-05 由卫生与公众服务部部长代表的美利坚合众国 保护哺乳动物组织抵抗冷和其他代谢应激的组合物和方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153582A (en) * 1998-11-05 2000-11-28 Bausch & Lomb Surgical, Inc. Defined serumfree medical solution for ophthalmology
CN102578078A (zh) * 2012-02-02 2012-07-18 温州医学院附属第二医院 一种神经细胞的冻存液及冻存方法
WO2014010685A1 (fr) * 2012-07-11 2014-01-16 石原産業株式会社 Conservateur pour l'utilisation dans la conservation à basse température de matière biologique, et procédé de conservation de matière biologique à basse température
CN103190392A (zh) * 2013-03-28 2013-07-10 北京大学第三医院 一种角膜中期保存液及其制备方法
CN109423473A (zh) * 2017-08-21 2019-03-05 青岛瑞思德生物科技有限公司 用于制备胎盘干细胞的试剂盒
CN111727961A (zh) * 2020-08-10 2020-10-02 医微细胞生物技术(广州)有限公司 一种牙髓干细胞冻存液及其冻存方法

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
AHLENSTIEL T ET AL: "Bioflavonoids attenuate renal proximal tubular cell injury during cold preservation in Euro-Collins and University of Wisconsin solutions", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 63, no. 2, 1 February 2003 (2003-02-01), pages 554 - 563, XP002337114, ISSN: 0085-2538, DOI: 10.1046/J.1523-1755.2003.00774.X *
BUMKE-VOGT CHRISTIANE ET AL: "The Flavones Apigenin and Luteolin Induce FOXO1 Translocation but Inhibit Gluconeogenic and Lipogenic Gene Expression in Human Cells", PLOS ONE, vol. 9, no. 8, 1 January 2014 (2014-01-01), pages e104321, XP055941751, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138109/pdf/pone.0104321.pdf> DOI: 10.1371/journal.pone.0104321 *
CHEN QINGHE ET AL: "Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells", PLOS ONE, vol. 5, no. 12, 14 December 2010 (2010-12-14), pages 1 - 11, XP055941778, Retrieved from the Internet <URL:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0015288&type=printable> DOI: 10.1371/journal.pone.0015288 *
GAVELLA M. ET AL: "Protective Effect of Gangliosides on DNA in Human Spermatozoa Exposed to Cryopreservation", JOURNAL OF ANDROLOGY., vol. 33, no. 5, 26 January 2012 (2012-01-26), US, pages 1016 - 1024, XP055906361, ISSN: 0196-3635, DOI: 10.2164/jandrol.111.015586 *
PEI YIFEI ET AL: "Combined effect of apigenin and ferulic acid on frozen-thawed boar sperm quality", ANIMAL SCIENCE JOURNAL - NIHON CHIKUSAN GAKKAIHO, vol. 89, no. 7, 1 July 2018 (2018-07-01), JP, pages 956 - 965, XP055906172, ISSN: 1344-3941, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fasj.13009> DOI: 10.1111/asj.13009 *
PLIN C ET AL: "Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 528, no. 1-3, 28 December 2005 (2005-12-28), pages 162 - 168, XP027695479, ISSN: 0014-2999, [retrieved on 20051228] *
SUKUMARAN PRAMOD ET AL: "Complexation of C6-Ceramide with Cholesteryl Phosphocholine - A Potent Solvent-Free Ceramide Delivery Formulation for Cells in Culture", PLOS ONE, vol. 8, no. 4, 19 April 2013 (2013-04-19), pages e61290, XP055906789, DOI: 10.1371/journal.pone.0061290 *
SUN Y. ET AL: "Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 83, no. 6, 1 June 2008 (2008-06-01), GB, pages 1512 - 1521, XP055906181, ISSN: 0741-5400, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584160/pdf/nihms387117.pdf> DOI: 10.1189/jlb.0108076 *
THURID AHLENSTIEL ET AL: "Improved Cold Preservation of Kidney Tubular Cells by Means of Adding Bioflavonoids to Organ Preservation Solutions", TRANSPLANTATION, vol. 81, no. 2, 1 January 2006 (2006-01-01), pages 231 - 239, XP055083603, ISSN: 0041-1337, DOI: 10.1097/01.tp.0000191945.09524.a1 *

Also Published As

Publication number Publication date
CN112602703B (zh) 2022-05-27
CA3202729A1 (fr) 2022-06-23
AU2021400321A1 (en) 2023-07-13
EP4262384A2 (fr) 2023-10-25
CN112602703A (zh) 2021-04-06
WO2022133247A2 (fr) 2022-06-23
US20240041023A1 (en) 2024-02-08

Similar Documents

Publication Publication Date Title
EP3170391B1 (fr) Solution de conservation de la cornée lamellaire
US9623149B2 (en) Method for producing an acellular dermal matrix, and acellular dermal matrix produced by same
WO2009049568A3 (fr) Greffon autologue, allogène ou xénogène stérile et son procédé de production
MX2018006803A (es) Formulaciones moldeables que contienen un oxisterol en una matriz de tejido acelular.
US11318228B2 (en) Crosslinked soft tissue graft and methods of use thereof
CN107252427A (zh) 用于促进损伤的身体组织再生的包含活性物质的组合物
WO2022133247A3 (fr) Composition et procédé de conservation de la viabilité d&#39;une cellule dans un environnement à basse température
Firat et al. Viability of cartilage grafts in various forms
Patterson et al. Methods to reduce the contraction of tissue-engineered buccal mucosa for use in substitution urethroplasty
Kagan et al. The skin bank
CN103844330B (zh) 食品环保防腐剂
Reich et al. Sporicidal efficacy of genipin: a potential theoretical alternative for biomaterial and tissue graft sterilization
NOVOTNA et al. Decellularization techniques of human foreskin for tissue engineering application
WO2006057876A3 (fr) Procede et solutions pour la conservation des tissus
CN106563173A (zh) 一种脱细胞生物真皮材料及其制备方法和应用
WO2022079063A3 (fr) Composition
JP2010227246A (ja) 脱細胞化生体組織の調製方法
BR112022015768A2 (pt) Métodos de tratamento e prevenção de arritmias de enxerto
Stocker et al. Medium term preservation of corneal tissue for grafting
CN111685101A (zh) 一种用于脱细胞板层角膜的保存运输液
Sachkov et al. Use of cadaver skin in the treatment of wounds
MX2023010287A (es) Composiciones para el cuidado de organos ex vivo.
Soejima et al. Wound dressing material containing lyophilized allogeneic cultured cells
CN114271261B (zh) 一种高效复合遗体保鲜剂及其制备方法和防腐方法
Kathapillai Modified saturated salt solution (MSSS) method for embalming

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 18258125

Country of ref document: US

ENP Entry into the national phase

Ref document number: 3202729

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2021400321

Country of ref document: AU

Date of ref document: 20211217

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2021844141

Country of ref document: EP

Effective date: 20230717

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21844141

Country of ref document: EP

Kind code of ref document: A2